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Gravity is also a field of forces that act on masses. | La gravité est également un champ de forces qui agit sur les masses. | en-fr-ca |
We can all picture astronauts in space. | Wir können uns Astronauten im Weltall vorstellen. | en-de |
They float freely in three dimensions without any forces acting on them. | Αιωρούνται ελεύθερα προς κάθε κατεύθυνση χωρίς κάποια δύναμη να επιδρά πάνω τους. | en-el |
But as that space shuttle returns to Earth, and as the astronauts enter the Earth's gravitational field, they begin to see the effects of gravity. | Mas assim que a nave espacial retorna à Terra e os astronautas entram no campo gravitacional da Terra, eles começam a sentir os efeitos da gravidade. | en-pt-br |
They begin to be attracted towards Earth. | Ils commencent à être attirés vers la Terre. | en-fr |
And as they land, they're fully aligned in the gravitational field. | 着陆时 重力场则完全作用于他们 | en-zh-cn |
We're, of course, all stuck in the Earth's gravitational field right now. | Mi smo svi, naravno zapeli trenutno u Zemljinom gravitacijskom polju. | en-hr |
That's why you're all in your chairs. | Por eso todos están en sus sillas. | en-es |
And that's why we have to use our muscle energy to stand up, to walk around and to lift things. | Por isso temos que usar a nossa energia muscular para nos levantarmos, andarmos e levantarmos coisas. | en-pt |
In cancer, cells rapidly divide and lead to uncontrolled tumor growth. | În cancer, celulele se divizează rapid și duc la creșterea necontrolată a tumorilor. | en-ro |
We can think of a cell from an electrical perspective as if it's a mini space station. | Podemos pensar numa célula numa perspetiva elétrica como se fosse uma mini estação espacial. | en-pt |
And in that space station we have the genetic material, the chromosomes, within a nucleus. | ובתחנת החלל הזו יש לנו חומר גנטי, הכרומוזומים, שנמצא בתוך גרעין. | en-he |
And out in the cytoplasmic soup we have special proteins that are required for cell division that float freely in this soup in three dimensions. | Y fuera de él, en el caldo de citoplasma tenemos proteínas especiales que se requieren para la división celular y que flotan libremente en el caldo en tres dimensiones. | en-es |
Importantly, those special proteins are among the most highly charged objects in our body. | ที่สำคัญยิ่งก็คือ โปรตีนเหล่านั้น คือวัตถุที่เป็นเปลี่ยนแปลงบ่อยครั้งมากที่สุด ในร่างกาย | en-th |
As cell division begins the nucleus disintegrates, the chromosomes line up in the middle of the cell and those special proteins undergo a three-dimensional sequence whereby they attach and they literally click into place end-on-end to form chains. | Când începe diviziunea celulei nucleul se dezintegrează și cromozomii se aliniază in centrul celulei, iar acele proteine speciale străbat un procedeu tridimensional prin care se atașează și se unesc cap la cap pentru a forma lanțuri. | en-ro |
These chains then progress and attach to the genetic material and pull the genetic material from one cell into two cells. | حرکت میکند و به مواد ژنیتیکی متصل میشن و این مواد از یک سلول به سلول دیگر می کشند. حرکت میکند و به مواد ژنیتیکی متصل میشن و این مواد از یک سلول به سلول دیگر می کشند. حرکت میکند و به مواد ژنیتیکی متصل میشن و این مواد از یک سلول به سلول دیگر می کشند. حرکت میکند و به مواد ژنیتیکی متصل میشن و این مواد از یک سلول به سلول دی... | en-fa |
And this is exactly how one cancer cell becomes two cancer cells, two cancer cells become four cancer cells, and we have ultimately uncontrolled tumor growth. | 这就是一个癌细胞分裂生两个的过程 这就是一个癌细胞分裂生两个的过程 两个癌细胞再变成四个 最后变成 无限增长的肿瘤 | en-zh-cn |
Tumor Treating Fields use externally placed transducers attached to a field generator to create an artificial electric field on that space station. | Les « Tumor Treating Fields » utilisent des transducteurs externes attachés à un générateur de champs pour créer un champ électrique artificiel sur cette station spatiale. | en-fr-ca |
And when that cellular space station is within the electric field, it acts on those highly charged proteins and aligns them. | E quando quella stazione spaziale è dentro il campo elettrico, agisce su quelle proteine altamente cariche e le allinea. | en-it |
And it prevents them from forming those chains, those mitotic spindles, that are necessary to pull the genetic material into the daughter cells. | và nó ngăn ngừa tiến trình tạo chuỗi của chúng những trục phân bào đó là cần thiết để kéo các yếu tố di truyền vào trong những tế bào con | en-vi |
What we see is that the cells will attempt to divide for several hours. | Ajo që ne shohim është se qelizat do të mundohen që të ndahen për orë të tëra. | en-sq |
And they will either enter into this so-called cellular suicide, programmed cell death, or they will form unhealthy daughter cells and enter into apoptosis once they have divided. | А затем они либо запускают процесс клеточного самоубийства, так называемого апоптоза — программированной клеточной смерти, либо образуют нездоровые дочерние клетки, в которых апоптоз запускается, как только они поделились. | en-ru |
And we can observe this. | Y lo podemos observar. | en-es |
What I'm going to show you next are two in vitro experiments. | Şimdi size iki vitro deneyi göstereceğim. | en-tr |
This is cultures, identical cultures, of cervical cancer cells. | Това са култури, идентични култури, от цервикални ракови клетки. | en-bg |
And we've stained these cultures with a green florescent dye so that we can look at these proteins that form these chains. | Мы окрасили эти культуры зелёным флуоресцирующим красителем, чтобы видеть эти белки, формирующие цепочки. | en-ru |
The first clip shows a normal cell division without the Tumor Treating Fields. | De eerste clip toont een normale celdeling zonder de Tumor Treating Fields. | en-nl |
What we see are, first of all, a very active culture, a lot of divisions, and then very clear nuclei once the cells have separated. | 여기서 보여지는 것은 첫번째로, 굉장히 활발한 배양 배지들, 많은 세포분열, 그리고 그뒤를 따르는 세포가 분열된 후에 매우 선명한 핵의 모습입니다. | en-ko |
And we can see them dividing throughout. | Ne mund të shohim se si ato ndahen. | en-sq |
When we apply the fields -- again, in the identical time-scale to the identical culture -- you're going to see something different. | Quando aplicamos os campos — numa escala de tempo idêntica e numa cultura idêntica — vemos algo diferente. | en-pt |
The cells round up for division, but they're very static in that position. | Les cellules se regroupent pour la division, mais elles sont très statiques dans cette position. | en-fr-ca |
We'll see two cells in the upper part of the screen attempting to divide. | Vom vedea două celule în partea de sus a ecranului incercând să se divizeze. | en-ro |
The one within the circle manages. | Cái nằm trong vòng tròn hoàn thành được | en-vi |
But see how much of the protein is still throughout the nucleus, even in the dividing cell. | Dar vedeți câtă proteină rămâne incă în nucleu, chiar și în celula care se divide. | en-ro |
The one up there can't divide at all. | 上面的那个根本无法分裂 | en-zh-cn |
And then this bubbling, this membrane bubbling, is the hallmark of apoptosis in this cell. | وفوران الغشاء هو السمة المميزة للاستماتة في هذه الخلية. | en-ar |
Formation of healthy mitotic spindles is necessary for division in all cell types. | Формиране на здрави митотични вретена е необходимо за деленето на всички видове клетки. | en-bg |
We've applied Tumor Treating Fields to over 20 different cancers in the lab, and we see this effect in all of them. | Ne e kemi aplikuar këtë Trajtim të Tumorit me Fusha në mbi 20 kancere te ndryshme dhe e kemi parë këtë efekt në secilen prej tyre. | en-sq |
Now importantly, these Tumor Treating Fields have no effect on normal undividing cells. | Bu Tümör Tedavi Alanlarının normal bölünmeyen hücrede etkisi olmamasıdır. | en-tr |
10 years ago, Dr. Palti founded a company called Novocure to develop his discovery into a practical therapy for patients. | Há 10 anos, o Dr. Palti fundou uma empresa chamada Novocure para desenvolver a sua descoberta como uma terapia prática para os doentes. | en-pt |
In that time, Novocure's developed two systems -- one system for cancers in the head and another system for cancers in the trunk of the body. | Novocure ontwikkelde twee systemen - een systeem voor kanker in het hoofd en ander systeem voor kanker in de romp. | en-nl |
The first cancer that we have focused on is the deadly brain cancer, GBM. | Le premier cancer sur lequel nous nous sommes penchés, est le cancer mortel du cerveau, le GBM. | en-fr |
GBM affects about 10,000 people in the U.S. each year. | Ο GBM προσβάλλει περίπου 10.000 ανθρώπους στις Η.Π.Α. | en-el |
It's a death sentence. | Es una sentencia de muerte. | en-es |
The expected five year survival is less than five percent. | Очакваното петгодишно оцеляване е по-малко от 5%. | en-bg |
And the typical patient with optimal therapy survives just a little over a year, and only about seven months from the time that the cancer is first treated and then comes back and starts growing again. | A tipičan pacijent s optimalnom terapijom poživi malo više od godine dana i oko samo sedam mjeseci od trenutka kada je rak prvi puta liječen, a onda se vraća i počinje ponovo rasti. | en-hr |
Novocure conducted its first phase three randomized trial in patients with recurrent GBM. | Novocure uskutočnil svoju prvú fázu troch náhodných skúšok na pacientoch s opakujúcim sa GBM. | en-sk |
So these are patients who had received surgery, high dose radiation to the head and first-line chemotherapy, and that had failed and their tumors had grown back. | To su pacijenti koji su bili podvrgnuti operacijama, visokoj dozi zračenja glave i inicijalnoj hemoterapiji, sve to je bilo bezuspešno i tumor je relapsirao. | en-sr |
We divided the patients into two groups. | قسّمنا المرضى لمجموعتين. | en-ar |
The first group received second-line chemotherapy, which is expected to double the life expectancy, versus no treatment at all. | Prva grupa primila je drugi niz kemoterapija za što je očekivano da će im udvostručiti životni vijek u odnosu na to da uopće nema liječenja. | en-hr |
And then the second group received only Tumor Treating Field therapy. | A druga grupa była leczona wyłącznie polem elektrycznym TTF | en-pl |
What we saw in that trial is that that the life expectancies of both groups -- so the chemotherapy treated group and the Tumor Treating Field group -- was the same. | Ceea ce am observat în acel experiment este că speranţa de viață în ambele grupuri-- deci a grupului tratat cu chimioterapie şi a celui tratat cu Câmp Anti-tumori-- a fost aceeași | en-ro |
But importantly, the Tumor Treating Field group suffered none of the side effects typical of chemotherapy patients. | Dar ceea ce este foarte important e că grupul tratat cu Câmp electric nu a suferit nici unul din efectele secundare tipice chimioterapiei. | en-ro |
They had no pain, suffered none of the infections. | При тях нямаше болка, нямаше никакви инфекции. | en-bg |
They had no nausea, diarrhea, constipation, fatigue that would be expected. | 没有恶心或腹泻 便秘或疲劳 这些可能的症状 | en-zh-cn |
Based on this trial, in April of this year, the FDA approved Tumor Treating Fields for the treatment of patients with recurrent GBM. | 基于今年4月的试验 基于今年4月的试验 FDA批准了肿瘤治疗电场法 用于GBM复发病人的 治疗 | en-zh-cn |
Importantly, it was the first time ever that the FDA included in their approval of an oncology treatment a quality of life claim. | Co ważne, po raz pierwszy w historii, FDA uwzględniła w aprobacie metody leczenia onkologicznego stwierdzenie dotyczące jakości życia. | en-pl |
So I'm going to show you now one of the patients from this trial. | Przedstawię Państwu teraz jednego z pacjentów biorących udział w tej próbie. | en-pl |
Robert Dill-Bundi is a famous Swiss cycling champion. | โรเบิร์ต ดิว-บันดิ เป็นนักปั่นจักรยานแชมป์โอลิมปิกที่ชื่อเสียงจากสวิส | en-th |
He won the gold medal in Moscow in the 4,000 meter pursuit. | A câștigat medalia de aur la Moscova în cursa de 4000 de metri. | en-ro |
And five years ago, Robert was diagnosed with GBM. | Și acum cinci ani Robert a fost diagnosticat cu GBM. | en-ro |
He received the standard treatments. | Ha ricevuto i trattamenti standard. | en-it |
He received surgery. | Il a été opéré. | en-fr-ca |
He received high dose radiation to the head. | Recibió grandes dosis de radiación en la cabeza. | en-es |
And he received first-line chemotherapy. | E recebeu quimioterapia de primeira linha. | en-pt-br |
A year after this treatment -- in fact, this is his baseline MRI. | Godinu dana nakon tog tretmana, ovo je ustvari njegov osnovni MR snimak. | en-sr |
You can see that the black regions in the upper right quadrant are the areas where he had surgery. | Vemos aquelas regiões pretas no quadrante superior direito que são as áreas onde foi operado. | en-pt |
And a year after that treatment, his tumor grew back with a vengeance. | E un anno dopo quel trattamento, il suo tumore è tornato con una vendetta. | en-it |
That cloudy white mass that you see is the recurrence of the tumor. | Ta biała, pierzasta plama, którą widzicie, to nawrót guza. | en-pl |
At this point, he was told by his doctors that he had about 3 months to live. | 在這種形狀下，他的醫生告訴他 他的壽命大概只有3個月左右。 | en-zh-tw |
He entered our trial. | И он решил принять участие в нашем исследовании. | en-ru |
And here we can see him getting the therapy. | 这里我们可以看到他在接受治疗 | en-zh-cn |
First of all, these electrodes are noninvasive. | Zunächst, diese Elektroden sind nichtinvasiv. | en-de |
They're attached to the skin in the area of the tumor. | Ato janë të bashkangjitura në lëkurë në pjesën e tumorit. | en-sq |
Here you can see that a technician is placing them on there much like bandages. | Ici vous voyez une technicienne appliquant les électrodes comme des bandages. | en-fr-ca |
The patients learn to do this themselves And then the patients can undergo all the activities of their daily life. | Los pacientes aprenden a hacerlo por si mismos Y después los pacientes pueden volver a las actividades de su vida diaria. | en-es |
There's none of the tiredness. | Nie je tam žiadna únava. | en-sk |
There's none of what is called the "chemo head." | pas de perte de cheveux, | en-fr-ca |
There's no sensation. | Ništa se ne oseća. | en-sr |
It doesn't interfere with computers or electrical equipment. | Nuk ndërhynë në kompjuterë apo pajisje elektrike. | en-sq |
And the therapy is delivered continuously at home, without having to go into the hospital either periodically or continually. | Und die Therapie wird kontinuierlich zu Hause erbracht, ohne dass man in eine Klinik gehen muss, weder periodisch noch ständig. | en-de |
These are Robert's MRIs, again, under only TTField treatment. | هذه صور الرنين المغناطيسي لروبرت مرة أخرى، وهو يخضع للعلاج بالحقل المعالج للورم. | en-ar |
This is a therapy that takes time to work. | この治療は効果が現れるまで時間がかかり | en-ja |
It's a medical device; it works when it's on. | Είναι ιατρική συσκευή· και λειτουργεί όταν είναι αναμμένη. | en-el |
But what we can see is, by month six, the tumor has responded and it's begun to melt away. | Ma ciò che vediamo è che, al sesto mese, il tumore ha risposto ed è cominciato a dissolversi. | en-it |
It's still there. | มันยังคงมีอยู่ตรงนั้น | en-th |
By month 12, we could argue whether there's a little bit of material around the edges, but it's essentially completely gone. | Vào tháng thứ 12 ta có thể thấy rằng còn có một ít vẩn xung quanh viền, nhưng cơ bản nó thật sự đã hết. | en-vi |
It's now five years since Robert's diagnosis, and he's alive, but importantly, he's healthy and he's at work. | Je to 5 rokov odkedy diagnostikovali Roberta, a on je živý, no, čo je dôležitejšie, je zdravý a pracuje. | en-sk |
I'm going to let him, in this very short clip, describe his impressions of the therapy in his own words. | سأدعه في مقطع الفيدو الصغير جدا هذا يصف انطباعاته حول العلاج بكلماته هو. | en-ar |
(Video) Robert Dill-Bundi: My quality of life, I rate what I have today a bit different than what most people would assume. | Տեսանյութ: Ռոբերտ Դիլլ- Բունդի: Իմ կյանքի որակը. ես, հակառակ շատերի ենթադրություններին, այսօր փոքր-ինչ այլ կերպ եմ գնահատում այն, ինչ ունեմ: | en-hy |
I am the happiest, the happiest person in the world. | Sou o mais feliz, a pessoa mais feliz do mundo. | en-pt-br |
And every single morning I appreciate life. | Jeden Morgen weiß ich mein Leben zu schätzen. | en-de |
Every night I fall asleep very well, and I am, I repeat, the happiest man in the world, and I'm thankful I am alive. | شبها خیلی خوب بخواب میرم ومن تکرار میکنم شادترین فرد دردنیا هستم وخیلی ممنونم که زنده هستم. | en-fa |
BD: Novocure's also working on lung cancer as the second target. | โนโวคิวยังทำงานเกี่ยวมะเร็งปอด โดยเป็นเป้าหมายถัดมา | en-th |
We've run a phase two trial in Switzerland on, again, recurrent patients -- patients who have received standard therapy and whose cancer has come back. | Fizemos um estudo clínico de segunda fase na Suíça novamente, em pacientes recorrentes -- pacientes que receberam terapia padrão e que o câncer tinha retornado. | en-pt-br |
I'm going to show you another clip of a woman named Lydia. | Unë do t'ju shfaq edhe një klip tjetër të një gruaje të quajtur Lydia. | en-sq |
Lydia's a 66 year-old farmer in Switzerland. | İsviçreli bir çiftçi. Beş yıl önce, | en-tr |
She was diagnosed with lung cancer five years ago. | Bola diagnostikovaná s rakovinou pľúc pred piatimi rokmi. | en-sk |
She underwent four different regimes of chemotherapy over two years, none of which had an effect. | dört farklı kemoterapi uygulandı ve bunların hiçbiri etkili olmadı. Kanser gittikçe yayıldı. | en-tr |
Her cancer continued to grow. | Cancerul ei a continuat să se dezvolte. | en-ro |
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