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And as we treat it with our compound, this addiction to sugar, this rapid growth, faded. | E, à medida que o tratamos com o nosso composto, esse vício em açúcar, esse crescimento acelerado, se extinguiu. | en-pt-br |
And on the animal on the right, you see that the cancer was responding. | Y en el animal de la derecha, se ve que el cáncer respondía al tratamiento. | en-es |
We've completed, now, clinical trials in four mouse models of this disease. | 我们现在已完成动物实验 用了4个动物模本 每一次我们都看到同样的结果 | en-zh-cn |
The mice with this cancer that get the drug live, and the ones that don't rapidly perish. | Больные раком мыши, получающие это лекарство, продолжают жить, а не получащие — умирают. | en-ru |
So we started to wonder, what would a drug company do at this point? | Comezamos entón a preguntarnos que faría unha farmacéutica no noso caso. | en-gl |
Well, they probably would keep this a secret until they turn the prototype drug into an active pharmaceutical substance. | Bom, provavelmente manteriam segredo até que tornassem esta molécula-protótipo num fármaco activo. | en-pt |
So we did just the opposite. | Postąpiliśmy na odwrót. Opublikowaliśmy artykuł, | en-pl |
We published a paper that described this finding at the earliest prototype stage. | που περιέγραφε αυτό το εύρημα στο πιο πρώιμο στάδιο του πρωτοτύπου. | en-el |
We gave the world the chemical identity of this molecule, typically a secret in our discipline. | 我們公佈了這個分子的化學名稱， 按規定通常這都應該屬於機密。 | en-zh-tw |
We told people exactly how to make it. | Казахме на хората как точно да я направят. | en-bg |
We gave them our email address, suggesting that if they write us, we'll send them a free molecule. | Mes davėme jiems savo elektroninio pašto adresą, pakišdami mintį, kad jei jie parašys mums, mes išsiųsime nemokamą molekulę. | en-lt |
(Laughter) We basically tried to create the most competitive environment for our lab as possible. | Basicamente, tentámos criar no nosso laboratório um ambiente o mais competitivo possível. E isto foi, infelizmente, um sucesso. | en-pt |
And this was, unfortunately, successful. | (Risos) | en-gl |
(Laughter) Because now, we've shared this molecule, just since December of last year, with 40 laboratories in the United States and 30 more in Europe -- many of them pharmaceutical companies, seeking now to enter this space, to target this rare cancer that, thankfully right now, is quite desirable to study in that indu... | เป็นเพราะเราแบ่งปันโมเลกุลนี้ ตั้งแต่ธันวาคมของปีที่แล้ว ให้กับห้องแล็ป 40 แห่งในอเมริกา และอีก 30 แห่งในยุโรป หลายๆแห่งเป็นบริษัทยา ที่กำลังหาทางที่จะเข้ามาศึกษา วิธีรักษามะเร็งที่พบไม่บ่อยชนิดนี้ เป็นที่น่ายินดี ที่ในปัจจุบัน มีความต้องการที่จะทำงานในอุตสาหกรรมนี้ค่อนข้างสูง | en-th |
But the science that's coming back from all of these laboratories about the use of this molecule has provided us insights we might not have had on our own. | Dar știința care vine înapoi din toate aceste laboratoare despre folosirea acestei molecule ne-a oferit perspective pe care nu le-am fi putut avea. | en-ro |
Leukemia cells treated with this compound turn into normal white blood cells. | سلولهای سرطان خون درمان شده با این ترکیب به گلبولهای سفید طبیعی تبدیل میشوند. سلولهای سرطان خون درمان شده با این ترکیب به گلبولهای سفید طبیعی تبدیل میشوند. | en-fa |
Mice with multiple myeloma, an incurable malignancy of the bone marrow, respond dramatically to the treatment with this drug. | Des souris atteinte d'un myélome multiple, une tumeur maligne incurable de la moelle osseuse, répondent de façon spectaculaire au traitement par ce médicament. | en-fr |
You might know that fat has memory. | Možda znate da masno tkivo može da pamti. Baš lepo što mogu to da vam demonstriram. | en-sr |
(Laughter) In fact, this molecule prevents this adipocyte, this fat stem cell, from remembering how to make fat, such that mice on a high-fat diet, like the folks in my hometown of Chicago -- (Laughter) fail to develop fatty liver, which is a major medical problem. | I zapravo, ova molekula spriječava ovaj adipocit, ovu masnu matičnu stanicu da se sjeti kako napraviti mast tako da miševi na dijeti bez visokih masnoća, poput ljudi iz mog rodnog grada Chicaga, ne uspiju razviti masnu jetru, koja je veliki medicinski problem. | en-hr |
What this research taught us -- not just my lab, but our institute, and Harvard Medical School more generally -- is that we have unique resources in academia for drug discovery; that our center, which has tested perhaps more cancer molecules in a scientific way than any other, never made one of its own. | この研究を通して 私の研究室だけでなく ハーバード大医学部全体が 学んだことがあります 学会には新薬の発見に役立つ 格別の資源があるということです 私が所属する研究施設では どこよりも多くの抗癌物質を 科学的に研究してきましたが 開発はしてきませんでした | en-ja |
For all the reasons you see listed here, we think there's a great opportunity for academic centers to participate in this earliest, conceptually tricky and creative discipline of prototype drug discovery. | Για όλους τους λόγους που βλέπετε ν' αναφέρονται εδώ, πιστεύουμε ότι υπάρχει μια σπουδαία ευκαιρία για τα ακαδημαϊκά κέντρα να συμμετάσχουν σ' αυτόν τον πρώιμο, εννοιολογικά περίπλοκο και δημιουργικό κλάδο της ανακάλυψης πρωτότυπων φαρμάκων. | en-el |
So what next? | それでは何を次に行うべきでしょうか？ | en-ja |
We have this molecule, but it's not a pill yet. | Avem această moleculă, dar nu este încă o pastilă. | en-ro |
It's not orally bioavailable. | มันยังไม่อยู่ในรูปที่กินได้ | en-th |
We need to fix it so we can deliver it to our patients. | אנחנו צריכים לתקן את זה, כך שנוכל לתת אותה לחולים שלנו. | en-he |
And everyone in the lab, especially following the interaction with these patients, feels quite compelled to deliver a drug substance based on this molecule. | I svi se u ovom laboratoriju, posebno prateći interakciju s tim pacijentima osjećaju prilično prisiljenima da naprave supstancu baziranu na ovoj molekuli. Ovdje moram reći | en-hr |
It's here where I'd say that we could use your help and your insights, your collaborative participation. | أن بإمكاننا الاستفادة من عونكم وبصيرتكم، مساهمتكم التعاونية. | en-ar |
Unlike a drug company, we don't have a pipeline that we can deposit these molecules into. | Za razliku od farmaceutske kompanije, mi nemamo proizvodnu liniju u koju možemo ubaciti ove molekule. | en-sr |
We don't have a team of salespeople and marketeers to tell us how to position this drug against the other. | qui puisse nous dire comment positionner ce médicament sur le marché. | en-fr |
What we do have is the flexibility of an academic center to work with competent, motivated, enthusiastic, hopefully well-funded people to carry these molecules forward into the clinic while preserving our ability to share the prototype drug worldwide. | Wat we wel hebben, is de flexibiliteit van de academische centra om te werken met competente, gemotiveerde, enthousiaste en hopelijk goed gefinancieerde mensen om verder te gaan met deze moleculen in een klinische setting en tegelijkertijd het vermogen te behouden om dit geneesmiddel-prototype met de wereld te delen. | en-nl |
This molecule will soon leave our benches and go into a small start-up company called Tensha Therapeutics. | Molekuła niedługo opuści ławkę rezerwowych i przejdzie do małej, młodej firmy, Tensha Therapeutics. | en-pl |
And, really, this is the fourth of these molecules to kind of "graduate" from our little pipeline of drug discovery, two of which -- a topical drug for lymphoma of the skin and an oral substance for the treatment of multiple myeloma -- will actually come to the bedside for the first clinical trial in July of this year ... | 그리고 진정으로 이것은 이 분자의 약 발견의 우리의 작은 파이프라인으로부터 졸업하는 종류의 네번째것입니다 그것중 2개는 - 피부의 림프종을 위한 논제가 되는 약인데, 다발성 골수종의 치료를 위한 구강 약물이 이해 7월에 첫번째 임상 실험을 위해 우리에게 아주 가깝게 오게 될 것입니다 우리를 위해서는 아주 중요하고 흥이나는 이정표이지요 | en-ko |
I want to leave you with just two ideas. | ผมอยากจะจบการสนทนาด้วยไอเดียสองข้อด้วยกัน | en-th |
The first is: if anything is unique about this research, it's less the science than the strategy. | 첫번째는 이 리서치에 관해 특별한 것이 있다면, 그건 전략보다는 과학이 덜 차지했다는 것입니다-- | en-ko |
This, for us, was a social experiment -- an experiment in "What would happen if we were as open and honest at the earliest phase of discovery chemistry research as we could be?" | що це для нас був соціальний експеримент, експеримент для з'ясування, що б сталося якби ми були такими відкритими і чесними, на самій ранній фазі відкриття хімічного досліду, якими ми тільки могли б бути. | en-uk |
This string of letters and numbers and symbols and parentheses that can be texted, I suppose, or Twittered worldwide, is the chemical identity of our pro compound. | Αυτό το μακρινάρι από γράμματα και νούμερα και σύμβολα και παρενθέσεις που μπορεί, φαντάζομαι, να σταλεί με μήνυμα σε κινητό ή στο Τουίτερ παγκοσμίως, είναι η χημική ταυτότητα της πρώιμης ένωσής μας. | en-el |
It's the information that we most need from pharmaceutical companies, the information on how these early prototype drugs might work. | Es la información más necesaria de las compañías farmacéuticas, la información sobre cómo fármacos prototipo podrían funcionar. | en-es |
Yet this information is largely a secret. | No entanto, essa informação é altamente secreta. | en-pt-br |
And so we seek, really, to download from the amazing successes of the computer-science industry, two principles -- that of open source and that of crowdsourcing -- to quickly, responsibly accelerate the delivery of targeted therapeutics to patients with cancer. | И така, ние се стремим наистина да използваме от невероятните успехи на компютърната индустрия два принципа: тези на "отворения код" и на "използване ресурсите на множеството," за да ускорим бързо, отговорно доставката на целева терапевтика за пациенти с рак. | en-bg |
Now, the business model involves all of you. | المشروع يشملكم جميعاً. | en-ar |
This research is funded by the public. | Esta investigación finánciaa o público. | en-gl |
It's funded by foundations. | Nó được tài trợ bởi các tổ chức. | en-vi |
And one thing I've learned in Boston is that you people will do anything for cancer, and I love that. | І ще про одну річ я дізнався в Бостоні, що ви, люди, зробите все заради раку, і мені це подобається. | en-uk |
You bike across the state, you walk up and down the river. | شما در سرتاسر آمریکا دوچرخه سواری میکنید.شما در کنار رودخانه با بالا و پایین قدم میزنید. | en-fa |
(Laughter) I've never seen, really, anywhere, this unique support for cancer research. | （笑声） 我在哪里都没有见过 如此独特地 支持癌症研究。 | en-zh-cn |
And so I want to thank you for your participation, your collaboration and most of all, for your confidence in our ideas. | И затова искам да ви благодаря за вашето участие, вашето сътрудничество и най-вече за доверието ви в нашите идеи. | en-bg |
(Applause) (Applause) I am a papercutter. | （拍手） （拍手） 私は切り絵師です | en-ja |
(Laughter) I cut stories. | (Râsete) Tai poveşti. | en-ro |
So my process is very straightforward. | Отже, хід моєї роботи - дуже простий. | en-uk |
I take a piece of paper, I visualize my story, sometimes I sketch, sometimes I don't. | Iau o bucată de hârtie, vizualizez povestea mea, uneori fac o schiţă, alteori, nu. | en-ro |
And as my image is already inside the paper, I just have to remove what's not from that story. | Aangezien mijn beeld reeds in het papier zit, hoef ik slechts te verwijderen wat niet van dat verhaal is. | en-nl |
So I didn't come to papercutting in a straight line. | Vậy nên tôi không cắt giấy theo một đường thẳng. | en-vi |
In fact, I see it more as a spiral. | De fato, vejo isso mais como uma espiral. | en-pt-br |
I was not born with a blade in my hand. | 我并不是生来 就对剪纸天赋异禀。 | en-zh-cn |
And I don't remember papercutting as a child. | І я не пам'ятаю, щоб я витинала у дитинстві. | en-uk |
As a teenager, I was sketching, drawing, and I wanted to be an artist. | Kao tinejdžerka crtala sam, skicirala i htela da budem umetnica. | en-sr |
But I was also a rebel. | Bola som však aj rebel. | en-sk |
And I left everything and went for a long series of odd jobs. | Ve her şeyi bir kenara bıraktım ve bir dizi tuhaf işlerin izinden gittim. | en-tr |
So among them, I have been a shepherdess, a truck driver, a factory worker, a cleaning lady. | Trong số đó, Tôi từng làm người chăm sóc cừu, người lái xe tải, công nhân phân xưởng, nhân viên lau dọn, | en-vi |
I worked in tourism for one year in Mexico, one year in Egypt. | Trabalhei em turismo um ano no México, um ano no Egito. | en-pt |
I moved for two years in Taiwan. | Fui viver durante dois anos em Taiwan. | en-pt |
And then I settled in New York where I became a tour guide. | Potom som sa usadila v New Yorku, kde som sa stala turistickou sprievodkyňou. | en-sk |
And I still worked as a tour leader, traveled back and forth in China, Tibet and Central Asia. | И продължих да работя като туристически водач, пътувах напред, назад до Китай, Тибет и Централна Азия. | en-bg |
So of course, it took time, and I was nearly 40, and I decided it's time to start as an artist. | Samozrejme, toto všetko zabralo čas a mala som už takmer 40 rokov, keď som sa rozhodla, že je čas začať ako umelkyňa. | en-sk |
(Applause) I chose papercutting because paper is cheap, it's light, and you can use it in a lot of different ways. | (Taps) A papírvágást választottam, mert a papír olcsó, könnyű, és rengeteg különböző módon használható fel. | en-hu |
And I chose the language of silhouette because graphically it's very efficient. | Dhe zgjodha gjuhen e siluetave. sepse nga ana grafike eshte shume efikase. | en-sq |
And it's also just getting to the essential of things. | Et elle va aussi à l'essentiel. | en-fr |
So the word "silhouette" comes from a minister of finance, Etienne de Silhouette. | Slovo "silueta" pochází od ministra financí, Etienna de Silhouette, | en-cs |
And he slashed so many budgets that people said they couldn't afford paintings anymore, and they needed to have their portrait "a la silhouette." | El a tăiat atâtea bugete, încât oamenii au spus că nu îşi mai permit deloc picturi şi că trebuie să îşi facă portretele "a la Silhouette." | en-ro |
(Laughter) So I made series of images, cuttings, and I assembled them in portfolios. | (Gülüşmeler) Kürülerden bir dizi görsel hazırladım ve bunları portfolyo haline getirdim. | en-tr |
And people told me -- like these 36 views of the Empire State building -- they told me, "You're making artist books." | Dan orang-orang berkata -- seperti pemandangan surealis dari Empire State building ini -- Mereka berkata, "Kau membuat buku seniman." | en-id |
So artist books have a lot of definitions. | Librat artistik kane shume perkufizime. | en-sq |
They come in a lot of different shapes. | 他们也有很多不同的形式。 | en-zh-cn |
But to me, they are fascinating objects to visually narrate a story. | 그러나 저에게 있어 아티스트 북은 시각적으로 이야기를 말하는 훌륭한 것입니다 그러나 저에게 있어 아티스트 북은 시각적으로 이야기를 말하는 훌륭한 것입니다 그러나 저에게 있어 아티스트 북은 시각적으로 이야기를 말하는 훌륭한 것입니다 | en-ko |
They can be with words or without words. | 그것은 단어가 들어있을수도 있고 들어있지 않을수도 있습니다 | en-ko |
And I have a passion for images and for words. | Tôi có một niềm đam mê cháy bỏng đối với những bức vẽ và những con chữ. | en-vi |
I love pun and the relation to the unconscious. | 저는 말장난과 알지 못하는 것들간의 관계를 좋아합니다 저는 말장난과 알지 못하는 것들간의 관계를 좋아합니다 | en-ko |
I love oddities of languages. | 様々な言語の持つおかしさも好きです | en-ja |
And everywhere I lived, I learned the languages, but never mastered them. | Де б я не жила, я вчила мови, але ніколи не володіла ними досконало. | en-uk |
So I'm always looking for the false cognates or identical words in different languages. | Тому я завжди шукаю споріднені мови або однакові слова з різних мов. | en-uk |
So as you can guess, my mother tongue is French. | Kao što možete da pretpostavite, moj maternji jezik je francuski. | en-sr |
And my daily language is English. | Günlük kullandığım dil ise İngilizce. | en-tr |
So I did a series of work where it was identical words in French and in English. | 저는 그래서 영어와 불어 사이에 어떤 연관된 단어가 있는지에 대해 일련의 일을 했습니다 저는 그래서 영어와 불어 사이에 어떤 연관된 단어가 있는지에 대해 일련의 일을 했습니다 저는 그래서 영어와 불어 사이에 어떤 연관된 단어가 있는지에 대해 일련의 일을 했습니다 | en-ko |
So one of these works is the "Spelling Spider." | ผลงานชิ้นหนึ่งในนั้น ก็คือ "แมงมุมนักสะกดคำ" | en-th |
So the Spelling Spider is a cousin of the spelling bee. | Et l'Araignée Orthographe est une cousine de l'abeille orthographe [compétition scolaire d'orthographe]. | en-fr |
(Laughter) But it's much more connected to the Web. | (Risadas) Mas é muito mais conectado à rede (Web). | en-pt-br |
(Laughter) And this spider spins a bilingual alphabet. | (Ծիծաղ) Ահա այս <<սարդի>> մեջ երկու այբբուններ են <<հյուսվում>>: | en-hy |
So you can read "architecture active" or "active architecture." | możecie więc przeczytać "architecture active" (fr.) lub "active architecture" (ang.) | en-pl |
So this spider goes through the whole alphabet with identical adjectives and substantives. | 所以這隻蜘蛛從整個字母表中 串連起相同的形容詞和名詞性實詞。 | en-zh-tw |
So if you don't know one of these languages, it's instant learning. | 所以就算你不了解其中某个语言， 你也立马就能学会。 | en-zh-cn |
And one ancient form of the book is scrolls. | Jednou ze starých forem knihy jsou svitky. | en-cs |
So scrolls are very convenient, because you can create a large image on a very small table. | Schriftrollen sind sehr praktisch, weil man ein sehr grosses Bildnis auf einem sehr kleinen Tisch herstellen kann. | en-de |
So the unexpected consequences of that is that you only see one part of your image, so it makes a very freestyle architecture. | התוצאה הבלתי צפויה של כך, היא שאנו רואים רק חלק מהתמונה, דבר המפיק סוג של ארכיטקטורה חופשית. | en-he |
And I'm making all those kinds of windows. | 我做了這些窗戶。 | en-zh-tw |
So it's to look beyond the surface. | jako pohled pod povrch. | en-cs |
It's to have a look at different worlds. | הם נועדו בכדי להציץ לעולמות שונים. | en-he |
And very often I've been an outsider. | E muito frequentemente tenho sido uma forasteira. | en-pt |
So I want to see how things work and what's happening. | takže chci vědět jak fungují a co se děje. | en-cs |
So each window is an image and is a world that I often revisit. | Tehát minden ablak egy kép, és egy világ, melyet gyakran újralátogatok. | en-hu |
And I revisit this world thinking about the image or cliché about what we want to do, and what are the words, colloquialisms, that we have with the expressions. | Ben de tekrar tekrar bu dünyayı geziyorum. Tasarlamak istediğim çizim ya da klişe üzerinde düşünüyorum Anlatımlarımızda kullandığımız deyimler hangileridir? | en-tr |
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