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Significant problems remained.
Encara tenien problemes importants.
en-ca
Turns out the gentleman in this picture is a guy named Joe Beery, who was lucky enough to be the CIO of a company called Life Technologies.
اتضح أن الرجل في الصورة اسمه جوي بيري، والذي كان لحسن الحظ كبير مسؤولي المعلومات في شركة تدعى Life Technologies. هم إحدى شركتين
en-ar
They're one of two companies that makes these massive whole-genome sequencing tools.
die diese grossen Werkzeuge zur Genomsequenzierung herstellen.
en-de
And so he got his kids sequenced.
Vad han gjorde var att han lät sekvensera ungarna.
en-sv
What they found was a series of mutations in a gene called SPR, which is responsible for producing serotonin, among other things.
Bunun sonucunda, başka bir takım görevleri yanında serotonin üretiminden sorumlu olan SPR adlı gende bir dizi mutasyonlar olduğu ortaya çıktı.
en-tr
So on top of L-Dopa, they gave these kids a serotonin precursor drug, and they're effectively normal now.
Kështu që përveç L-Dopa fëmijve ju dha edhe një ilac precursor serotonine, dhe ata ndihen normal tani.
en-sq
Guys, this would never have happened without whole-genome sequencing.
Ребята, этого никогда бы не случилось, не будь доступно секвенирование целого генома.
en-ru
At the time -- this was a few years ago -- it cost $100,000.
בזמנו, זה היה לפני כמה שנים, זה עלה $100,000. היום זה $10,000, בשנה הבאה זה $1,000.
en-he
Today it's $10,000, next year, $1,000, the year after, $100, give or take a year.
Jövőre 1.000 dollár lesz. Az azutáni évben 100 dollár lesz, esetleg még egy év múlva. Ennyire gyorsan fejlődik ez a dolog.
en-hu
That's how fast this is moving.
Oto mały Nick --
en-pl
So here's little Nick -- likes Batman and squirt guns.
voli Batmana i oružje.
en-hr
And it turns out Nick shows up at the children's hospital with this distended belly, like a famine victim.
Na del që Niku shkon tek spitali i fëmijve me një zgjerim stomaku sikur të ishte viktime urije.
en-sq
And it's not that he's not eating; it's that when he eats, his intestine basically opens up and feces spill out into his gut.
Bukan karena dia tidak makan, tapi karena setiap dia makan, ususnya terbuka dan feses tumpah ke perutnya.
en-id
So a hundred surgeries later, he looks at his mom and says, "Mom, please pray for me.
Pēc simtiem operāciju viņš paskatās uz savu mammu un saka: „Mamm,
en-lv
I'm in so much pain."
나를 위해 기도해주세요. 난 너무 아파요."
en-ko
His pediatrician happens to have a background in clinical genetics and he has no idea what's going on, but he says, "Let's get this kid's genome sequenced."
Son pédiatre avait une expérience en génétique clinique, il n'avait aucune idée de ce qui se passait, mais il proposa de séquencer le génome de l'enfant.
en-fr
And what they find is a single-point mutation in a gene responsible for controlling programmed cell death.
Und was sie finden, ist ein Single-Point-Mutation in einem Gen, das für die Kontrolle des programmierten Zelltodes verantwortlich ist.
en-de
So the theory is that he's having some immunological reaction to what's going on -- to the food, essentially.
وبالتالي النظرية كانت أنه كان لديه نوع من رد الفعل المناعي مع الذي يحصل أساسا للطعام،
en-ar
And that's a natural reaction, which causes some programmed cell death, but the gene that regulates that down is broken.
a to je prirodna reakcija koja uzrokuje neke apoptoze. Ali gen koji regulira tu reakciju je “pokvaren”.
en-hr
And so this informs, among other things, of course, a treatment for bone marrow transplant, which he undertakes.
Ovo nas upućuje, između ostalih stvari, naravno, na tretman transplantacije koštane srži, kojem se dječak podvrgava. I nakon devet mjeseci napornog oporavka,
en-hr
And after nine months of grueling recovery, he's now eating steak with A1 sauce.
ai tani është në gjendje të hajë bërxollë me salcë pikante. (Te qeshura)
en-sq
(Laughter) The prospect of using the genome as a universal diagnostic is upon us today.
Genoma izmantošanas perspektīva kā universāls diagnostikas līdzeklis mums šodien ir pieejams. Nu tas ir klāt.
en-lv
Today. It's here.
Bu aslında buradaki herkesin
en-tr
And what it means for all of us is that everybody in this room could live an extra 5, 10, 20 years, just because of this one thing.
hogy az itt ülők mind tovább élhetnek öt, 10, 20 évvel, csak emiatt az egy dolog miatt.
en-hu
Which is a fantastic story, unless you think about humanity's footprint on the planet, and our ability to keep up food production.
É uma história fantástica, perdendo apenas para a marca da humanidade no planeta e nossa habilidade em manter a produção de alimentos.
en-pt-br
So it turns out that the very same technology is also being used to grow new lines of corn, wheat, soybean and other crops that are highly tolerant of drought, of flood, of pests and pesticides.
Okazuje się jednak, że ta sama technologia służy również do uprawy nowych odmian kukurydzy, pszenicy, soi i innych roślin uprawnych, które są wysoce odporne na suszę, powódź, szkodniki i pestycydy.
en-pl
Now, look -- as long as we continue to increase the population, we'll have to continue to grow and eat genetically modified foods.
従って 人口が増えていく限り 遺伝子組み換え食品を育て 口にしなければならない
en-ja
Unless there's anybody in the audience who'd like to volunteer to stop eating?
นอกเสียจากว่ามีใครซักคน ในหมู่ผู้ฟัง ที่อยากจะอาสาหยุดกิน?
en-th
None, not one.
Ninguém, nem um.
en-pt
This is a typewriter, a staple of every desktop for decades.
هذه آلة كاتبة، أداة أساسية في كل مكتب لعقود.
en-ar
And, in fact, the typewriter was essentially deleted by this thing.
Aslında daktilo, gördüğünüz bu şey yüzünden yerinden oldu.
en-tr
And then more general versions of word processors came about.
Och sen kom det nya sorters ordbehandlare.
en-sv
But ultimately, it was a disruption on top of a disruption.
І кінець-кінцем, це було витіснення за витісненням.
en-uk
It was Bob Metcalfe inventing the Ethernet, and the connection of all these computers that fundamentally changed everything.
L'invenció d'Ethernet per part de Bob Metcalfe i la conexió d'aquests ordinadors va ser el fet fonamental que va canviar les coses.
en-ca
Suddenly we had Netscape, we had Yahoo.
И изведнъж получихме Netscape и Yahoo
en-bg
And we had, indeed, the entire dot-com bubble.
e assistemmo al fiorire del fenomeno dei siti Web.
en-it
(Laughter) Not to worry though, that was quickly rescued by the iPod, Facebook and, indeed, Angry Birds.
را داشتیم. (خنده ی حضار) اگرچه لازم به نگرانی نیست، چرا که سریعا به وسیله ی iPod و Facebook نجات داده شد و صد البته، Angry Birds!
en-fa
(Laughter) Look, this is where we are today.
(Suara tawa) Lihat, inilah posisi kita saat ini.
en-id
This is the genomic revolution today. This is where we are.
Đây là một cuộc cách mạng gen. Đây là vị trí của chúng ta. Vì vậy điều mà tôi muốn bạn xem xét là:
en-vi
What I'd like you to consider is: What does it mean when these dots don't represent the individual bases of your genome, but they connect to genomes all across the planet?
當這些不僅僅代表 你個人基因組的基對,而是與全世界的 基因組聯繫再一起意味著甚麼?
en-zh-tw
I just recently had to buy life insurance, and I was required to answer: A. I have never had a genetic test; B. I've had one, here you go; or C. I've had one and I'm not telling.
Отже, нещодавно мені довелось придбати страхування життя. І я повинен був відповісти: А. Я ніколи не проходив генетичний тест, В. Я його проходив, ось вам результат. і С. Я проходив його, але результат не скажу.
en-uk
Thankfully, I was able to answer A, and I say that honestly, in case my life insurance agent is listening.
Felizmente, pude dar a resposta A, e digo-o honestamente, não vá o meu agente de seguros estar a ouvir.
en-pt
But what would have happened if I had said C?
Але, що би трапилось, якби я дав відповідь С?
en-uk
Consumer applications for genomics will flourish.
سوف تزدهر تطبيقات المستهلك في علم الجينوم.
en-ar
Do you want to see if you're genetically compatible with your girlfriend?
Vill du se om du är genetiskt kompatibel med din flickvän. Självklart. DNA-sekvensering på din iPhone?
en-sv
(Laughter) Personalized genomic massage, anyone?
(ضحك) تدليك جينومي مخصص هل من أحد؟
en-ar
There's already a lab today that tests for allele 334 of the AVPR1 gene, the so-called cheating gene.
Dnes už existuje laboratórium, ktoré testuje alelu 334 z AVPR1 génu, takzvaný gén podvádzania. Takže každý, kto tu je dnes so svojou polovičkou,
en-sk
(Laughter) So anybody who's here today with your significant other, just turn over to them, swab their mouth, send it to the lab and you'll know for sure.
vienkārši pagriezieties pret viņu un paņemiet paraugu no viņa mutes, aizsūtiet to uz laboratoriju un jūs to skaidri zināsit. (Smiekli)
en-lv
(Laughter) Do you really want to elect a president whose genome suggests cardiomyopathy?
Chcete naozaj voliť prezidenta, ktorého gény napovedajú poruchy srdca? Porozmýšľajte, je rok 2016
en-sk
Think of it -- it's 2016, and the leading candidate releases not only her four years of back-tax returns, but also her personal genome.
và một ứng cử viên đang dẫn đầu không những đưa ra tờ khai truy thu thuế trong bốn năm mà còn có cả bộ gen cá nhân của mình. và điều đó thật sự tốt.
en-vi
Then she challenges all her competitors to do the same.
Kemudian dia menantang para lawannya untuk melakukan hal yang sama. Apa menurut Anda itu tidak akan terjadi?
en-id
Do you think that's not going to happen?
Думаете, это бы помогло Джону МакКейну?
en-ru
Do you think it would have helped John McCain?
(Risas)
en-es
(Laughter) How many people in the audience have the last name Resnick, like me?
Cik daudz cilvēkiem publikā ir tāds pats uzvārds, Resniks, kā man?
en-lv
Raise your hand.
請舉手。喔,舉高點,拜託!
en-zh-tw
Anybody? Nobody.
明显,有一两个
en-zh-cn
Typically, there's one or two.
Babamın babası on Resnick kardeşten biriydi.
en-tr
So my father's father was one of 10 Resnick brothers.
他們都互討厭,
en-zh-tw
They all hated each other, and all moved to different parts of the planet.
És mind a bolygó különböző tájaira költöztek.
en-hu
So it's likely I'm related to every Resnick that I ever meet, but I don't know.
Il est fort possible que je sois lié à chaque Resnick que je rencontre, mais je ne sais pas.
en-fr
So imagine if my genome were De-identified, sitting in software, And a third cousin's genome was also sitting there, and there was software that could compare the two and make these associations.
แต่ลองคิดดูถ้าผมมีพันธุกรรมที่ถูกเรียงลำดับ เก็บอยู่ในโปรแกรม และพันธุกรรมของญาติลำดับที่สามของผมนั่งอยู่ตรงนั้น และก็มีโปรแกรมที่ช่วยเปรียบเทียบมันทั้ง 2 เข้าด้วยกัน ที่จะรู้ถึงความเชื่อมโยงนี้ มันไม่ยากเกินที่จะจินตนาการ บริษัทของผมมีโปรแกรมที่จะช่วยทำสิ่งนั้นได้ในตอนนี้แล้ว
en-th
Not hard to imagine. My company has software that does this right now.
לחברה שלי יש תוכנה שעושה את זה ממש היום.
en-he
Imagine one more thing, that that software is able to ask both parties for mutual consent: "Would you be willing to meet your third cousin?"
Immaginate anche un'altra cosa: che quel software fosse capace di chiedere ad entrambe le parti un mutuo consenso, "Vorresti conoscere tuo cugino di terzo grado?"
en-it
And if we both say yes -- voilà!
両者が「はい」と言えば
en-ja
Welcome to Chromosomally LinkedIn.
Sim salabim! Selamat datang di LinkedIn untuk kromosom.
en-id
(Laughter) Now this is probably a good thing, right?
(Risos) Seria provavelmente uma coisa boa, certo?
en-pt-br
Bigger clan gatherings and so on.
你可以有个大家族
en-zh-cn
But maybe it's a bad thing as well.
也可能是坏事
en-zh-cn
How many fathers in the room? Raise your hands.
这屋子里有多少父亲?请举手
en-zh-cn
OK, so experts think that one to three percent of you are not actually the father of your child.
Podignite svoje ruke. U redu, stručnjaci misle da 1 do 3 odsto očeva u stvari nisu očevi svoje dece.
en-sr
(Laughter) Look -- (Laughter) These genomes, these 23 chromosomes, they don't in any way represent the quality of our relationships or the nature of our society -- at least not yet.
(Γέλια) Κοιτάξτε -- (Γέλια) Αυτά τα γονιδιώματα, αυτά τα 23 χρωμοσώματα, δεν αντιπροσωπεύου με κανέναν τρόπο την ποιότητα των σχέσεών μας ή την φύση της κοινωνίας μας -- τουλάχιστον όχι ακόμα.
en-el
And like any new technology, it's really in humanity's hands to wield it for the betterment of mankind or not.
đó thực sự nằm trong tầm tay của loài người có nên sử dụng nó để cải thiện nhân loại, hay là không. Và vì thế tôi thúc giục các bạn tình dậy và tập trung
en-vi
And so I urge you all to wake up and to tune in and to influence the genomic revolution that's happening all around you.
并参与到这场发生在你们周围的基因革命
en-zh-cn
I want to say that really and truly, after these incredible speeches and ideas that are being spread, I am in the awkward position of being here to talk to you today about television.
Tôi muốn nói một cách chân thành rằng, so với những bài diễn thuyết đáng khâm phục và những ý tưởng tuyệt vời đang được lan truyền, tôi ở trong một tình huống không đẹp mắt chút nào khi đứng ở đây ngày hôm nay và nói với các bạn về các chương trình tivi.
en-vi
So most everyone watches TV.
Evet, pek çoğumuz TV izleriz.
en-tr
We like it. We like some parts of it.
Szeretjük. Részben szeretjük.
en-hu
Here in America, people actually love TV.
مردم در امریکا، واقعاً عاشق تلویزیون هستند.
en-fa
The average American watches TV for almost 5 hours a day.
L'américain moyen regarde la télé presque 5 heures par jour.
en-fr
Okay?
Okej?
en-pl
Now I happen to make my living these days in television, so for me, that's a good thing.
Tôi vô tình lại kiếm sống qua tivi, thế nên điều đó đối với tôi là rất tốt.
en-vi
But a lot of people don't love it so much.
Mais beaucoup de gens ne l'aiment pas assez.
en-fr-ca
They, in fact, berate it.
هم ، في الحقيقة ، يحاربونه
en-ar
They call it stupid, and worse, believe me.
Din que é inútil, e cousas peores, crédeme.
en-gl
My mother, growing up, she called it the "idiot box."
Mi madre creció llamándola la "caja tonta".
en-es
But my idea today is not to debate whether there's such a thing as good TV or bad TV; my idea today is to tell you that I believe television has a conscience.
Mais mon idée aujourd'hui n'est pas de débattre pour savoir s'il y a une bonne ou une mauvaise télé ; mon idée aujourd'hui est de vous dire que je crois que la télévision a une conscience.
en-fr
So why I believe that television has a conscience is that I actually believe that television directly reflects the moral, political, social and emotional need states of our nation -- that television is how we actually disseminate our entire value system.
为什么我相信电视有良知 因为我相信 电视直接地反映了国民在 道德,政治 社会和情绪上的需要 因为电视是我们传播 整个价值体系的方法
en-zh-cn
So all these things are uniquely human, and they all add up to our idea of conscience.
Tüm bunlar insana has ve bunların toplamı bizim vicdan yapımızı oluşturuyor.
en-tr
Now today, we're not talking about good and bad TV.
所以今天我們不講電視的好壞
en-zh-tw
We're talking about popular TV.
우리는 "요 근래 TV"에 대해 이야기하고 있습니다.
en-ko
We're talking about top-10 Nielsen-rated shows over the course of 50 years.
Govorimo o prvih deset rangiranih emisija od strane Nielsen-a u periodu od pedeset godina.
en-sr
How do these Nielsen ratings reflect not just what you've heard about, which is the idea of our social, collective unconscious, but how do these top-10 Nielsen-rated shows over 50 years reflect the idea of our social conscience?
Kā šie „Nielsen” vērtējumi atspoguļo ne tikai to, ko jūs tikko dzirdējāt par mūsu sociālo, kopējo zemapziņu, taču arī to, kā šie 10 labākie raidījumi „Nielsen” vērtējumā pēdējo 50 gadu laikā atspoguļo mūsu priekšstatu par sociālo sirdsapziņu?
en-lv
How does television evolve over time, and what does this say about our society?
Bagaimana televisi berkembang dari waktu ke waktu dan apa artinya bagi masyarakat kita?
en-id
Now speaking of evolution, from basic biology, you probably remember that the animal kingdom, including humans, have four basic primal instincts.
Тепер, говорячи про розвиток, з основ біології, ви мабуть пам'ятаєте, що царство тварин, включаючи людину, має 4 основні інстинкти.
en-uk
You have hunger; you have sex; you have power; and you have the urge for acquisitiveness.
Je hebt honger; je hebt seks; je hebt macht; en je hebt de drang naar hebzucht.
en-nl
As humans, what's important to remember is that we've developed, we've evolved over time to temper, or tame, these basic animal instincts.
به عنوان انسان آنچه مهم است به خاطر داشته باشیم این است که ما در طول زمان توسعه و تکامل یافته ایم تا این غرایز حیوانی پایه را رام کنیم.
en-fa
We have the capacity to laugh and cry.
Siamo in grado di ridere e piangere.
en-it
We feel awe, we feel pity.
Αισθανόμαστε δέος και συμπόνοια.
en-el
That is separate and apart from the animal kingdom.
Isso é separado e à parte no reino animal.
en-pt
The other thing about human beings is that we love to be entertained.
A másik tény az emberről, hogy szeretjük, ha szórakoztatnak minket.
en-hu
We love to watch TV.
Мы любим смотреть телевизор.
en-ru