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Homotopic groups in a chemical compound are equivalent groups. Two groups A and B are homotopic if the molecule remains achiral when the groups are interchanged with some other atom (such as bromine) while the remaining parts of the molecule stay fixed. Homotopic atoms are always identical, in any environment. Homotopi...
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Theoretical and Fundamental Chemistry
Until recently, there were only two known pathways to process Okazaki fragments. However, current investigations have concluded that a new pathway for Okazaki fragmentation and DNA replication exists. This alternate pathway involves the enzymes Pol δ with Pif1 which perform the same flap removal process as Pol δ and FE...
1
Applied and Interdisciplinary Chemistry
The International System of Units (SI) unit of radioactive activity is the becquerel (Bq), named in honor of the scientist Henri Becquerel. One Bq is defined as one transformation (or decay or disintegration) per second. An older unit of radioactivity is the curie, Ci, which was originally defined as "the quantity or m...
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Theoretical and Fundamental Chemistry
Homologation reactions like the Kowalski ester homologation provide simple examples of insertion process in organic synthesis. In the Arndt-Eistert reaction, a methylene unit is inserted into the carboxyl-carbon bond of carboxylic acid to form the next acid in the homologous series. Organic Syntheses provides the exa...
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Theoretical and Fundamental Chemistry
Some ionic liquids have been shown to reduce friction and wear in basic tribological testing, and their polar nature makes them candidate lubricants for tribotronic applications. While the comparatively high cost of ionic liquids currently prevents their use as neat lubricants, adding ionic liquids in concentrations as...
0
Theoretical and Fundamental Chemistry
A bioindicator is any species (an indicator species) or group of species whose function, population, or status can reveal the qualitative status of the environment. The most common indicator species are animals. For example, copepods and other small water crustaceans that are present in many water bodies can be monitor...
1
Applied and Interdisciplinary Chemistry
The National perspective plan envisions about 150-million-acre feet (MAF) (185 billion cubic meters) of water storage along with building inter-links. These storages and the interlinks will add nearly 170 million acre feet of water for beneficial uses in India, enabling irrigation over an additional area of 35 million...
1
Applied and Interdisciplinary Chemistry
The Geochemical Society was founded in 1955 at a meeting of the Geological Society of America. Its first president was Earl Ingerson and dues started at two dollars per year. In 1990 it was incorporated as a 501(c)(3) nonprofit organization in 1990. In 1988, the Geochemical society created the Goldschmidt Conferences i...
0
Theoretical and Fundamental Chemistry
miRNA-324-5p is a relatively new and understudied microRNA. It is an important regulator in several diseases, and its effects span across the body from neuronal dysregulation in seizure to hepatocellular carcinoma and cardiac disease. Because microRNAs have numerous targets, they are capable of regulating multiple path...
1
Applied and Interdisciplinary Chemistry
Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. It was discovered in 1990 in the lab of Roger D. Kornberg, recipient of the 2006 Nobel Prize in Chemistry. Mediator complexes interact with transcription factors and RNA polymerase II. The main function of mediator com...
1
Applied and Interdisciplinary Chemistry
Calcium carbide, also known as calcium acetylide, is a chemical compound with the chemical formula of CaC. Its main use industrially is in the production of acetylene and calcium cyanamide. The pure material is colorless, while pieces of technical-grade calcium carbide are grey or brown and consist of about 80–85% of C...
1
Applied and Interdisciplinary Chemistry
The Ginzburg–Landau equation, named after Vitaly Ginzburg and Lev Landau, describes the nonlinear evolution of small disturbances near a finite wavelength bifurcation from a stable to an unstable state of a system. At the onset of finite wavelength bifurcation, the system becomes unstable for a critical wavenumber whi...
1
Applied and Interdisciplinary Chemistry
In coordination chemistry, a coordinate covalent bond, also known as a dative bond, dipolar bond, or coordinate bond is a kind of two-center, two-electron covalent bond in which the two electrons derive from the same atom. The bonding of metal ions to ligands involves this kind of interaction. This type of interactio...
0
Theoretical and Fundamental Chemistry
The discoverers were reluctant to assert an oxidation state of the iron centers in the compound, instead deferring the details of the electronic structure to computational studies. The crystal structure reveals that the three iron centers arrange in an equilateral triangle (nearly ideal; Fe1 = 59.67°, Fe2 = 60.15°, and...
0
Theoretical and Fundamental Chemistry
In PET imaging, [F]FDG is primarily used for imaging tumors in oncology, where a static [F]FDG PET scan is performed and the tumor [F]FDG uptake is analyzed in terms of Standardized Uptake Value (SUV). FDG PET/CT can be used for the assessment of glucose metabolism in the heart and the brain. [F]FDG is taken up by cell...
1
Applied and Interdisciplinary Chemistry
* Orbifold signature: * Coxeter notation: [∞,2,∞] or [∞,2,∞] * Lattice: rhombic * Point group: D * The group cm contains no rotations. It has reflection axes, all parallel. There is at least one glide reflection whose axis is not a reflection axis; it is halfway between two adjacent parallel re...
0
Theoretical and Fundamental Chemistry
Like the ALR genes, the MRS2 gene was cloned and sequenced before it was identified as a Mg transporter. The MRS2 gene was identified in the nuclear genome of yeast in a screen for suppressors of a mitochondrial gene RNA splicing mutation, and was cloned and sequenced by Wiesenberger et al. (1992). Mrs2p was not identi...
1
Applied and Interdisciplinary Chemistry
BTO draws upon the comprehensive enzyme specific data of the BRENDA enzyme information system. Presently (October 2019) 112,200 enzyme-organism-tissue specific data from more than 11,000 proteins are stored in BRENDA. These entries were manually annotated from more than 150,000 different literature references. All term...
1
Applied and Interdisciplinary Chemistry
Recently, the Woodward–Hoffmann rules have been reinterpreted using conceptual density functional theory (DFT). The key to the analysis is the dual descriptor function, proposed by Christophe Morell, André Grand and Alejandro Toro-Labbé , the second derivative of the electron density with respect to the number of e...
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Theoretical and Fundamental Chemistry
A heterogeneous mixture (e. g. liquid and solid) can be separated by mechanical separation processes like filtration or centrifugation. Homogeneous mixtures can be separated by molecular separation processes; these are either equilibrium-based or rate-controlled. Equilibrium-based processes are operating by the formati...
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Theoretical and Fundamental Chemistry
Margaret was an only child, born in Berkeley, California to mother Margaret Orchard and father John Melhase, who worked as a geologist. During her time at UC Berkeley, Melhase was a member of the Berkeley Folk Dancers and edited the group's newsletter. She met mathematics professor Robert A. Fuchs at a folk dance, and ...
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Theoretical and Fundamental Chemistry
TopFIND is a resource for comprehensive coverage of protein N- and C-termini discovered by all available in silico, in vitro as well as in vivo methodologies. It makes use of existing knowledge by seamless integration of data from UniProt and MEROPS and provides access to new data from community submission and manual l...
1
Applied and Interdisciplinary Chemistry
The coffee-ring pattern originates from the capillary flow induced by the evaporation of the drop: liquid evaporating from the edge is replenished by liquid from the interior. The resulting current can carry nearly all the dispersed material to the edge. As a function of time, this process exhibits a "rush-hour" effect...
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Theoretical and Fundamental Chemistry
Both HHV and LHV can be expressed in terms of AR (all moisture counted), MF and MAF (only water from combustion of hydrogen). AR, MF, and MAF are commonly used for indicating the heating values of coal: * AR (as received) indicates that the fuel heating value has been measured with all moisture- and ash-forming mineral...
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Theoretical and Fundamental Chemistry
Once the soluble compounds from the creosote preservative leach into the water, the compounds begin reacting with the external environment or are consumed by organisms. The reactions vary depending on the concentration of each compound that is released from the creosote, but major reactions are outlined below:
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Theoretical and Fundamental Chemistry
It has been shown that the activity of the sorbent reduces quite markedly in laboratory, bench-scale and pilot plant tests. This degradation has been attributed to three main mechanisms, as shown below.
1
Applied and Interdisciplinary Chemistry
During a meeting of the New York Academy of Sciences Section of Geology and Mineralogy in 1903, geologist Amadeus William Grabau proposed a new rock classification system in his paper Discussion of and Suggestions Regarding a New Classification of Rocks'. Within the primary subdivision of "Endogenetic rocks" – rocks fo...
0
Theoretical and Fundamental Chemistry
It is possible to do these simple calculations on paper or to use software. A program which does it can be obtained free of charge. In 2020 David Brown published a nearly comprehensive set of bond valence parameters on the IuCr web site.
0
Theoretical and Fundamental Chemistry
The mammalian target of rapamycin (mTOR), also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of...
1
Applied and Interdisciplinary Chemistry
In this group of mechanisms, the strain is accommodated by migration of vacancies in crystallographic lattice. This results in a change in crystal shape involving the transfer of mass by diffusion. These migrations are oriented towards sites of maximum stress and are limited by the grain boundaries; which conditions a ...
1
Applied and Interdisciplinary Chemistry
Some alternatives to IVF are: *Artificial insemination, including intracervical insemination and intrauterine insemination of semen. It requires that a woman ovulates, but is a relatively simple procedure, and can be used in the home for self-insemination without medical practitioner assistance. The beneficiaries of ar...
1
Applied and Interdisciplinary Chemistry
Sacrificial writing into function tissue (SWIFT) is a method of organ printing where living cells are packed tightly to mimic the density that occurs in the human body. While packing, tunnels are carved to mimic blood vessels and oxygen and essential nutrients are delivered via these tunnels. This technique pieces toge...
1
Applied and Interdisciplinary Chemistry
Reagent grade detergents are employed for the isolation and purification of integral membrane proteins found in biological cells. Solubilization of cell membrane bilayers requires a detergent that can enter the inner membrane monolayer. Advancements in the purity and sophistication of detergents have facilitated struct...
0
Theoretical and Fundamental Chemistry
Aminosulfuranes compare favorably with many of the other fluorination methods available. They are easier to handle than sulfur tetrafluoride; however SF does not promote cationic rearrangements. With respect to carboxylic acids, aminosulfuranes and SF are complementary: the former gives acid fluorides, while the latter...
0
Theoretical and Fundamental Chemistry
Polypropylene is suitable for use with foodstuffs, potable and ultra pure waters, as well as within the pharmaceutical and chemical industries. PP is a thermoplastic polymer made from polypropylene. It was first invented in the 1950s and has been used for pipes since the 1970s. Due to the high impact resistance combine...
1
Applied and Interdisciplinary Chemistry
Archaeometallurgical experimentation typically takes place in controlled laboratories or tries to remain as authentic as possible by being conducted using only the materials and facilities that were available to the subjects whose technology is trying to be reconstructed. Regardless of location though, the experimentat...
1
Applied and Interdisciplinary Chemistry
Although black lights produce light in the UV range, their spectrum is mostly confined to the longwave UVA region, that is, UV radiation nearest in wavelength to visible light, with low frequency and therefore relatively low energy. While low, there is still some power of a conventional black light in the UVB range. U...
0
Theoretical and Fundamental Chemistry
Manganese is found in leafy green vegetables, fruits, nuts, cinnamon and whole grains. The nutritious kernel, called wheat germ, which contains the most minerals and vitamins of the grain, has been removed from most processed grains (such as white bread). The wheat germ is often sold as livestock feed. Many common v...
1
Applied and Interdisciplinary Chemistry
In the Middle Bronze (MB) Age (end of 3rd–middle of 2nd millennium BCE) hundreds of metal objects were found. The development of more complex weapons (longer daggers, swords, complex battle axes, etc.) was possible by alloying the copper with arsenic or with tin. All the MBII weapons that were analyzed were made of cop...
1
Applied and Interdisciplinary Chemistry
All crystal structures belong to one of thirty-two crystal classes based on the number of rotational axes and reflection planes they possess that leave the crystal structure unchanged (point groups). Of the thirty-two crystal classes, twenty-one are non-centrosymmetric (not having a centre of symmetry). Of these twenty...
0
Theoretical and Fundamental Chemistry
Mediator is a crucial component for transcription initiation. Mediator interacts with the pre-initiation complex, composed of RNA Polymerase II and general transcription factors TFIIB, TFIID, TFIIE, TFIIF, and TFIIH to stabilize and initiate transcription. Studies of Mediator-RNA Pol II contacts in budding yeast have e...
1
Applied and Interdisciplinary Chemistry
Copper can exist in non-ionic form (as Cu) or in one of two redox states: Cu (reduced) or Cu (oxidized). Each form of Cu has a specific distribution of electrons (i.e., electron configuration), tabulated below: The electronic configurations of Cu control the number and types of bonds Cu can form with other atoms (e.g.,...
0
Theoretical and Fundamental Chemistry
In chemistry and fluid mechanics, the volume fraction is defined as the volume of a constituent V divided by the volume of all constituents of the mixture V prior to mixing: Being dimensionless, its unit is 1; it is expressed as a number, e.g., 0.18. It is the same concept as volume percent (vol%) except that the latt...
0
Theoretical and Fundamental Chemistry
The strength and directionality of halogen bonds are a key tool in the discipline of crystal engineering, which attempts to shape crystal structures through close control of intermolecular interactions. Halogen bonds can stabilize copolymers or induce mesomorphism in otherwise isotropic liquids. Indeed, halogen bond-...
0
Theoretical and Fundamental Chemistry
Consider a planar disk of infinite radius rotating at a constant angular velocity in fluid which is initially at rest everywhere. Near to the surface, the fluid is being turned by the disk, due to friction, which then causes centrifugal forces which move the fluid outwards. This outward radial motion of the fluid near...
1
Applied and Interdisciplinary Chemistry
In vertebrates, ferritin is usually found within cells, although it is also present in smaller quantities in the plasma.
1
Applied and Interdisciplinary Chemistry
In Japan, with the passage of the 2003 Soil Contamination Countermeasures Law, there is a strong movement to conduct Phase I studies more routinely. At least one jurisdiction in Canada (Ontario) now requires the completion of a Phase I prior to the transfer of some types of industrial properties. Some parts of Europe...
1
Applied and Interdisciplinary Chemistry
The standard pressure, , is used to define the reference state for the Van 't Hoff equation, which is where denotes the natural logarithm, is the thermodynamic equilibrium constant, and is the ideal gas constant. This equation is exact at any one temperature and all pressures, derived from the requirement that the ...
0
Theoretical and Fundamental Chemistry
Cyanate esters can be cured and postcured by heating, either alone at elevated temperatures or at lower temperatures in presence of a suitable catalyst. The most common catalysts are transition metal complexes of cobalt, copper, manganese and zinc. The result is a thermoset material with a very high glass-transition te...
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Theoretical and Fundamental Chemistry
* Soil applied: Herbicides applied to the soil are usually taken up by the root or shoot of the emerging seedlings and are used as preplant or preemergence treatment. Several factors influence the effectiveness of soil-applied herbicides. Weeds absorb herbicides by both passive and active mechanisms. Herbicide adsorpti...
1
Applied and Interdisciplinary Chemistry
In this technique the cells are lysed in alkaline conditions. The DNA in the mixture is denatured (strands separated) by disrupting the hydrogen bonds between the two strands. The large genomic DNA is subject to tangling and staying denatured when the pH is lowered during the neutralization. In other words, the strands...
1
Applied and Interdisciplinary Chemistry
Ruthenium forms highly active catalysts. Allowing milder operating pressures and temperatures, Ru-based materials are referred to as second-generation catalysts. Such catalysts are prepared by the decomposition of triruthenium dodecacarbonyl on graphite. A drawback of activated-carbon-supported ruthenium-based catalyst...
0
Theoretical and Fundamental Chemistry
In fluid dynamics, inviscid flow is the flow of an inviscid fluid which is a fluid with zero viscosity. The Reynolds number of inviscid flow approaches infinity as the viscosity approaches zero. When viscous forces are neglected, such as the case of inviscid flow, the Navier–Stokes equation can be simplified to a form...
1
Applied and Interdisciplinary Chemistry
Thiourea is employed as a source of sulfide, such as for converting alkyl halides to thiols. The reaction capitalizes on the high nucleophilicity of the sulfur center and easy hydrolysis of the intermediate isothiouronium salt: In this example, ethane-1,2-dithiol is prepared from 1,2-dibromoethane: Like other thioamide...
0
Theoretical and Fundamental Chemistry
The p3 protein is anchored to one end of the virion by the C-terminal domain of p3. Infection of host bacteria involves interaction of two different N-terminal regions of p3 with two different sites of the host bacteria. First, the N2 domain of p3 attaches to the outer tip of the F-pilus, and the pilus retracts into th...
1
Applied and Interdisciplinary Chemistry
The starting material for calcium looping is limestone, which is environmentally benign and widely available, accounting for over 10% (by volume) of all sedimentary rock. Limestone is already mined and cheaply obtainable. The mining process has no major known adverse environmental effects, beyond the unavoidable intrus...
1
Applied and Interdisciplinary Chemistry
This is a highly competitive area and a number of people claim patents in the field, most notably Alere (formerly Inverness Medical Innovations, now owned by Abbott) who own patents originally filed by Unipath. The US 6,485,982 patent, that has been litigated, expired in 2019. A number of other companies also hold pate...
1
Applied and Interdisciplinary Chemistry
In the U.S., a push for revisions of the FD&C Act emerged from Congressional hearings led by Senator Estes Kefauver of Tennessee in 1959. The hearings covered a wide range of policy issues, including advertising abuses, questionable efficacy of drugs, and the need for greater regulation of the industry. While momentum ...
1
Applied and Interdisciplinary Chemistry
Alkenes are named for their parent alkane chain with the suffix "-ene" and a numerical root indicating the position of the carbon with the lower number for each double bond in the chain: is but-1-ene. Multiple double bonds take the form -diene, -triene, etc., with the size prefix of the chain taking an extra "a": is ...
0
Theoretical and Fundamental Chemistry
A different, but related, mechanism is Dexter electron transfer. An alternative method to detecting protein–protein proximity is the bimolecular fluorescence complementation (BiFC), where two parts of a fluorescent protein are each fused to other proteins. When these two parts meet, they form a fluorophore on a timesca...
1
Applied and Interdisciplinary Chemistry
Although nearly 100% sulfuric acid solutions can be made, the subsequent loss of sulfur trioxide| at the boiling point brings the concentration to 98.3% acid. The 98.3% grade, which is more stable in storage, is the usual form of what is described as "concentrated sulfuric acid". Other concentrations are used for diffe...
0
Theoretical and Fundamental Chemistry
In organic chemistry, a methylene bridge, methylene spacer, or methanediyl group is any part of a molecule with formula ; namely, a carbon atom bound to two hydrogen atoms and connected by single bonds to two other distinct atoms in the rest of the molecule. It is the repeating unit in the skeleton of the unbranched a...
0
Theoretical and Fundamental Chemistry
Nesslers reagent, named after Julius Neßler (Nessler), is a 0.09 mol/L solution of potassium tetraiodomercurate(II) in 2.5 mol/L potassium hydroxide. This pale solution becomes deeper yellow in the presence of ammonia (). At higher concentrations, a brown precipitate derivative of Millons base () may form. The sensitiv...
0
Theoretical and Fundamental Chemistry
Vacuum ceramic filters are to be found in the following industries: * paper making * metallurgy * water treatment * chemical * ore beneficiation process in mining (iron, gold, nickel, copper and quartz). The process is used during a large continuous process of separating free filtering suspensions where washing is ...
0
Theoretical and Fundamental Chemistry
Pyruvate decarboxylation or pyruvate oxidation, also known as the link reaction (or oxidative decarboxylation of pyruvate), is the conversion of pyruvate into acetyl-CoA by the enzyme complex pyruvate dehydrogenase complex. The reaction may be simplified as: :Pyruvate + NAD + CoA → Acetyl-CoA + NADH + CO Pyruvate oxi...
1
Applied and Interdisciplinary Chemistry
After phase II reactions, the xenobiotic conjugates may be further metabolized. A common example is the processing of glutathione conjugates to acetylcysteine (mercapturic acid) conjugates. Here, the γ-glutamate and glycine residues in the glutathione molecule are removed by gamma-glutamyl transpeptidase and dipeptidas...
1
Applied and Interdisciplinary Chemistry
Reaction (a) is the sum of reactions (b) and (c), for which the total ΔH = −393.5 kJ/mol, which is equal to ΔH in (a). </li> </ol>
0
Theoretical and Fundamental Chemistry
In 1999, Meléndez et al claimed that the structure of glycogen is optimal under a particular metabolic constraint model, where the structure was suggested to be "fractal" in nature. However, research by Besford et al used small angle X-ray scattering experiments accompanied by branching theory models to show that glyco...
1
Applied and Interdisciplinary Chemistry
Rabi resonance method is a technique developed by Isidor Isaac Rabi for measuring the nuclear spin. The atom is placed in a static magnetic field and a perpendicular rotating magnetic field. We present a classical treatment in here.
0
Theoretical and Fundamental Chemistry
The term wetware is used to describe the protocols and molecular devices used in molecular biology and synthetic biology. Where biological components and systems are treated in a similar manner to software, and similar development models and methodologies are applied, the term wetware can be used to imply an approach t...
1
Applied and Interdisciplinary Chemistry
Sumerian cuneiform tablets record prescriptions for medicine. Ancient Egyptian pharmacological knowledge was recorded in various papyri, such as the Ebers Papyrus of 1550 BC and the Edwin Smith Papyrus of the 16th century BC. The very beginnings of pharmaceutical texts were written on clay tablets by Mesopotamians. Som...
1
Applied and Interdisciplinary Chemistry
In contrast to antiporters, symporters move ions or molecules in the same direction. In this case both ions being transported will be moved either from the exoplasmic space into the cytoplasmic space or from the cytoplasmic space into the exoplasmic space. An example of a symporter is the sodium-glucose linked transpor...
1
Applied and Interdisciplinary Chemistry
Elemental iodine is an oxidizing irritant, and direct contact with skin can cause lesions, so iodine crystals should be handled with care. Solutions with high elemental iodine concentration such as tincture of iodine are capable of causing tissue damage if use for cleaning and antisepsis is prolonged. Although elementa...
1
Applied and Interdisciplinary Chemistry
A monovalent ion requires 1 electron for discharge, a divalent ion requires 2 electrons for discharge and so on. Thus, if electrons flow, atoms are discharged. Thus, the mass discharged is where * is the Avogadro constant; * is the total charge, equal to the number of electrons () times the elementary charge ; * i...
0
Theoretical and Fundamental Chemistry
Olfactory processing of chemical signals like pheromones exists in all animal phyla and is thus the oldest of the senses. It has been suggested that it serves survival by generating appropriate behavioral responses to the signals of threat, sex and dominance status among members of the same species. Furthermore, it has...
1
Applied and Interdisciplinary Chemistry
Under the evidence of Jean Baptiste Perrins experiments on Brownian motion that confirmed Albert Einsteins theory, Ostwald renounced to energeticism as physical theory in his fourth edition of Outline of General Chemistry in 1908, embracing atomic theory. However he modified energeticism into an ontological philosophy,...
1
Applied and Interdisciplinary Chemistry
Terphthalaldehyde is used in the preparation of imines, which are also commonly referred to as Schiff bases, following a condensation reaction with amines. During this reaction, water is also formed. This reaction is also reversible. However, due to aromatic conjugation with the benzene ring, the imines are relatively ...
0
Theoretical and Fundamental Chemistry
The existence of two or more binding domains increases the difficulty of synthesis for chimeric molecules. Each component must be discovered, optimized, and synthesized in such a way that they can be linked together, driving up cost relative to single-domain inhibitors. The large size of chimeric molecules (typically 7...
1
Applied and Interdisciplinary Chemistry
Most detection mechanisms involved in small molecule sensors comprise some modulation in the fluorescent behavior of the sensing molecule upon binding the target metal. When a metal coordinates to such a sensor, it may either enhance or reduce the original fluorescent emission. The former is known as the Chelation Enha...
0
Theoretical and Fundamental Chemistry
When water flows through cracks present in concrete, water may dissolve various minerals present in the hardened cement paste or in the aggregates, if the solution is unsaturated with respect to them. Dissolved ions, such as calcium (Ca), are leached out and transported in solution some distance. If the physico-chemica...
1
Applied and Interdisciplinary Chemistry
In Japan, drugs and medical devices are given the designation as an orphan drug or device based on the Act of Securing Quality, Efficacy, Safety of Pharmaceuticals, Medical Devices, Regenerative or Cellular Therapy Products, Gene Therapy Products, and Cosmetics if they are intended for use in less than 50,000 patients ...
1
Applied and Interdisciplinary Chemistry
Drugs receive regulatory approval and are granted patents for only a single polymorph. In a classic patent dispute, the GlaxoSmithKline defended its patent for the Type II polymorph of the active ingredient in Zantac against competitors while that of the Type I polymorph had already expired. Polymorphism in drugs can ...
0
Theoretical and Fundamental Chemistry
Deflagrations are often used in engineering applications when the force of the expanding gas is used to move an object such as a projectile down a barrel, or a piston in an internal combustion engine. Deflagration systems and products can also be used in mining, demolition and stone quarrying via gas pressure blasting ...
0
Theoretical and Fundamental Chemistry
Immediate manifestations of caustic substance ingestions include erosions of mucosal surfaces of the gastrointestinal tract or airway (which can cause bleeding if the erosions extend to a blood vessel), mouth and tongue swelling, drooling or hypersalivation, nausea, vomiting, dyspnea, dysphonia/aphonia irritation of th...
1
Applied and Interdisciplinary Chemistry
fMRS has several advantages over other functional neuroimaging and brain biochemistry detection techniques. Unlike push-pull cannula, microdialysis and in vivo voltammetry, fMRS is a non-invasive method for studying dynamics of biochemistry in an activated brain. It is done without exposing subjects to ionizing radiati...
0
Theoretical and Fundamental Chemistry
As of November 2019, arketamine is under development for the treatment of depression under the developmental code names PCN-101 by Perception Neuroscience in the United States and HR-071603 by Jiangsu Hengrui Medicine in China.
0
Theoretical and Fundamental Chemistry
In the aldol reaction, the diastereoselectivity of the product is often dictated by the geometry of the enolate. The Zimmerman–Traxler model predicts that the Z enolate will give syn products, and that E enolates will give anti products. Reactions catalyzed by tin-based CLAs allow products to deviate from this pattern....
0
Theoretical and Fundamental Chemistry
Taking advantage of the unique tip geometry of the NFP nanomaterials are directly injected into live cells with minimal invasiveness. This enables unique studies of nanoparticle-mediated delivery, as well as cellular pathways and toxicity. Whereas typical in vitro studies are limited to cell populations, these broadly-...
1
Applied and Interdisciplinary Chemistry
Nanocars are a new class of molecular machines that can roll across solid surfaces with structurally defined direction. They are molecules essentially composed of a few tens or hundreds of hydrogen and carbon atoms and are measuring one to three nanometers. The nanocar is propelled step by step by electrical impulses a...
0
Theoretical and Fundamental Chemistry
Some authors define stereographic projection from the north pole (0, 0, 1) onto the plane , which is tangent to the unit sphere at the south pole (0, 0, −1). This can be described as a composition of a projection onto the equatorial plane described above, and a homothety from it to the polar plane. The homothety scales...
0
Theoretical and Fundamental Chemistry
After receiving his doctorate in 1952, he remained at TU. He continued his research on the organometallic chemistry of the transition metal. He almost immediately challenged the structure for ferrocene as postulated by Pauson and Keally. Shortly thereafter, he published the structural data of ferrocene and the new com...
0
Theoretical and Fundamental Chemistry
NIM811 is a mitochondrial permeability transition inhibitor. Also known as N-methyl-4-isoleucine cyclosporin, it is a four-substituted cyclosporine analogue that binds to cyclophilin, however this binary complex cannot bind to calcineurin, and therefore lacks immunosuppressive activity. NIM811 is a form of treatment fo...
1
Applied and Interdisciplinary Chemistry
A bimetallic strip is a strip that consists of two strips of different metals which expand at different rates as they are heated. They are used to convert a temperature change into mechanical displacement. The different expansions force the flat strip to bend one way if heated, and in the opposite direction if cooled b...
1
Applied and Interdisciplinary Chemistry
PAMORAs act by inhibiting the binding of opioids agonist to the μ-opioid receptor (MOR). The objective of PAMORAs treatment is to restore the enteric nervous system function (ENS). The MOR is found in several places in the body and PAMORAs is a competitive antagonist for binding to the receptor. The MORs in the gastroi...
1
Applied and Interdisciplinary Chemistry
Choi Yang-do was born in Seoul, South Korea. He studied agricultural chemistry at Seoul National University (1972-1976) and graduated with a BS degree. From 1976 to 1978 he received a MS degree in biological science from Korea Advanced Institute of Science and Technology (KAIST) and earned his Ph.D. in biochemistry, m...
1
Applied and Interdisciplinary Chemistry
Traces of many aldehydes are found in essential oils and often contribute to their favorable odours, e.g. cinnamaldehyde, cilantro, and vanillin. Possibly because of the high reactivity of the formyl group, aldehydes are not common in several of the natural building blocks: amino acids, nucleic acids, lipids. Most suga...
0
Theoretical and Fundamental Chemistry
A direct repeat occurs when a sequence is repeated with the same pattern downstream. There is no inversion and no reverse complement associated with a direct repeat. The nucleotide sequence written in bold characters signifies the repeated sequence. It may or may not have intervening nucleotides. Linguistically, a typ...
1
Applied and Interdisciplinary Chemistry
The Blepharisma nuclear code (translation table 15) is a genetic code found in the nuclei of Blepharisma.
1
Applied and Interdisciplinary Chemistry
The auxiliary can be removed from the desired amine by treatment with hydrochloric acid in protic solvents. <br />
0
Theoretical and Fundamental Chemistry
After Alexis Moussalli died in 1955, his heirs dismissed SECOR administrators, but the company faced increasing competition and lost market shares. In 1962, the company was sold to Lafarge laboratories, which were in turn purchased by Sanofi in 1976. Lafarge closed the Vichy factory in 1965 and relocated to Châteauroux...
0
Theoretical and Fundamental Chemistry