ID
stringlengths
13
17
question
stringlengths
88
1.13k
answer
stringlengths
6
156
reference_sequence
stringlengths
4.1k
4.1k
variant_sequence
stringlengths
4.1k
4.1k
Task1_train_24000
Here is a genetic alteration in NF1 (neurofibromin 1) on Chromosome 17. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Neurofibromatosis, type 1
TGCTTAATTACAATAGGAAAAAGTTATATTTTTACGAAGCAAATGTGTGTACCTAATACCTTTATTTGGAGGGGACATGTAGCTTTAGAATGAAAGCTTTTGGGGGGATAACTGTTTTATATAATTACATACCATACAGTTCACCCATTTAAAGTGTCCAATTCAGTGACTGTTTTTAATGTATTCACAGAGTTGTGCAACCATCACCACAATCAAGTTTTAGAACAATTTCATCAATTGAGAAAAAAACCCCGTACCCTTTAGCTATCTCTGCCTCTAACCACCCCCCACCCACTTTCTTGCCTCTCTTCCCCCAACGT...
TGCTTAATTACAATAGGAAAAAGTTATATTTTTACGAAGCAAATGTGTGTACCTAATACCTTTATTTGGAGGGGACATGTAGCTTTAGAATGAAAGCTTTTGGGGGGATAACTGTTTTATATAATTACATACCATACAGTTCACCCATTTAAAGTGTCCAATTCAGTGACTGTTTTTAATGTATTCACAGAGTTGTGCAACCATCACCACAATCAAGTTTTAGAACAATTTCATCAATTGAGAAAAAAACCCCGTACCCTTTAGCTATCTCTGCCTCTAACCACCCCCCACCCACTTTCTTGCCTCTCTTCCCCCAACGT...
Task1_train_24001
This variant lies on Chromosome 17 and affects the gene NF1 (neurofibromin 1). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Neurofibromatosis, type 1
ACAATAGGAAAAAGTTATATTTTTACGAAGCAAATGTGTGTACCTAATACCTTTATTTGGAGGGGACATGTAGCTTTAGAATGAAAGCTTTTGGGGGGATAACTGTTTTATATAATTACATACCATACAGTTCACCCATTTAAAGTGTCCAATTCAGTGACTGTTTTTAATGTATTCACAGAGTTGTGCAACCATCACCACAATCAAGTTTTAGAACAATTTCATCAATTGAGAAAAAAACCCCGTACCCTTTAGCTATCTCTGCCTCTAACCACCCCCCACCCACTTTCTTGCCTCTCTTCCCCCAACGTCTCTAGCCC...
ACAATAGGAAAAAGTTATATTTTTACGAAGCAAATGTGTGTACCTAATACCTTTATTTGGAGGGGACATGTAGCTTTAGAATGAAAGCTTTTGGGGGGATAACTGTTTTATATAATTACATACCATACAGTTCACCCATTTAAAGTGTCCAATTCAGTGACTGTTTTTAATGTATTCACAGAGTTGTGCAACCATCACCACAATCAAGTTTTAGAACAATTTCATCAATTGAGAAAAAAACCCCGTACCCTTTAGCTATCTCTGCCTCTAACCACCCCCCACCCACTTTCTTGCCTCTCTTCCCCCAACGTCTCTAGCCC...
Task1_train_24002
This gene mutation involves NF1 (neurofibromin 1) on Chromosome 17. Is it associated with any clinical condition, or is it benign?
Pathogenic; Neurofibromatosis, type 1
ACTCGGCTGATTATATTAGTGTATGATAAAAATAGATCAGTGGCTCTTTAAAAATGTATATGGTAATTTTATGGGTTGATTTTAATGTATATTTTACATTTTTTGTACTTTTGTCATGGAAGAAATGTTGGATAAAGCATAATTTGTCAAGTCTCAACTAATTAAGGTTTAATTCATGCTTTGCACAAAAATTTTGTGTTTAGGCTGCTGAAAGCCTTCACAAGACCATTGTTAAGAGGCGAATGTCCCATGTGAGTGGAGGAGGATCCATAGATTTGTCTGACACAGACTCCCTACAGGAATGGATCAACATGACTGGC...
ACTCGGCTGATTATATTAGTGTATGATAAAAATAGATCAGTGGCTCTTTAAAAATGTATATGGTAATTTTATGGGTTGATTTTAATGTATATTTTACATTTTTTGTACTTTTGTCATGGAAGAAATGTTGGATAAAGCATAATTTGTCAAGTCTCAACTAATTAAGGTTTAATTCATGCTTTGCACAAAAATTTTGTGTTTAGGCTGCTGAAAGCCTTCACAAGACCATTGTTAAGAGGCGAATGTCCCATGTGAGTGGAGGAGGATCCATAGATTTGTCTGACACAGACTCCCTACAGGAATGGATCAACATGACTGGC...
Task1_train_24003
Assess the clinical impact of this variant on gene NF1 (neurofibromin 1), found on Chromosome 17. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Neurofibromatosis, type 1
AAGGTAGCCAGAAGTTGTGTACGTTCTTTTCTAAATAAATATCTTATTGTTTTCAAACTTACATTTAATTCGTTTTACTTGATGACTAAAGTATTTAGAATGCCTTCTCTTTTGTCTATATCTGATAATTTTTTTATTGTTTCTATGTCTATATAGGTATGTTCGTGTGCTTGGGAATATGGTCCATGCAATTCAAATAAAAACGAAACTGTGTCAATTAGTTGAAGTAATGATGGCAAGGAGAGATGACCTCTCATTTTGCCAAGAGATGAAATTTAGGTGAGTTCTCAAAAGAGCAATGTAGGGTCTTGTAAATCTTA...
AAGGTAGCCAGAAGTTGTGTACGTTCTTTTCTAAATAAATATCTTATTGTTTTCAAACTTACATTTAATTCGTTTTACTTGATGACTAAAGTATTTAGAATGCCTTCTCTTTTGTCTATATCTGATAATTTTTTTATTGTTTCTATGTCTATATAGGTATGTTCGTGTGCTTGGGAATATGGTCCATGCAATTCAAATAAAAACGAAACTGTGTCAATTAGTTGAAGTAATGATGGCAAGGAGAGATGACCTCTCATTTTGCCAAGAGATGAAATTTAGGTGAGTTCTCAAAAGAGCAATGTAGGGTCTTGTAAATCTTA...
Task1_train_24004
Here is a genetic alteration in NF1 (neurofibromin 1) on Chromosome 17. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Neurofibromatosis, type 1
AGGTAGCCAGAAGTTGTGTACGTTCTTTTCTAAATAAATATCTTATTGTTTTCAAACTTACATTTAATTCGTTTTACTTGATGACTAAAGTATTTAGAATGCCTTCTCTTTTGTCTATATCTGATAATTTTTTTATTGTTTCTATGTCTATATAGGTATGTTCGTGTGCTTGGGAATATGGTCCATGCAATTCAAATAAAAACGAAACTGTGTCAATTAGTTGAAGTAATGATGGCAAGGAGAGATGACCTCTCATTTTGCCAAGAGATGAAATTTAGGTGAGTTCTCAAAAGAGCAATGTAGGGTCTTGTAAATCTTAA...
AGGTAGCCAGAAGTTGTGTACGTTCTTTTCTAAATAAATATCTTATTGTTTTCAAACTTACATTTAATTCGTTTTACTTGATGACTAAAGTATTTAGAATGCCTTCTCTTTTGTCTATATCTGATAATTTTTTTATTGTTTCTATGTCTATATAGGTATGTTCGTGTGCTTGGGAATATGGTCCATGCAATTCAAATAAAAACGAAACTGTGTCAATTAGTTGAAGTAATGATGGCAAGGAGAGATGACCTCTCATTTTGCCAAGAGATGAAATTTAGGTGAGTTCTCAAAAGAGCAATGTAGGGTCTTGTAAATCTTAA...
Task1_train_24005
A variant has been detected on Chromosome 17 in NF1 (neurofibromin 1). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Neurofibromatosis, type 1
GTGACTAAAGGTGTGTGTGTGGCTTCAAAAACATTGTTTGCTGTTTCTCTTTTCTCCACCATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGA...
GTGACTAAAGGTGTGTGTGTGGCTTCAAAAACATTGTTTGCTGTTTCTCTTTTCTCCACCATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGA...
Task1_train_24006
Gene NF1 (neurofibromin 1), found on Chromosome 17, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Neurofibromatosis, type 1
AAGGTGTGTGTGTGGCTTCAAAAACATTGTTTGCTGTTTCTCTTTTCTCCACCATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAG...
AAGGTGTGTGTGTGGCTTCAAAAACATTGTTTGCTGTTTCTCTTTTCTCCACCATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAG...
Task1_train_24007
This is a variant in NF1 (neurofibromin 1), located on Chromosome 17. Is this mutation a likely cause of disease or not?
Pathogenic; Neurofibromatosis, type 1
GTGTGTGTGTGGCTTCAAAAACATTGTTTGCTGTTTCTCTTTTCTCCACCATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACT...
GTGTGTGTGTGGCTTCAAAAACATTGTTTGCTGTTTCTCTTTTCTCCACCATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACT...
Task1_train_24008
The gene NF1 (neurofibromin 1) is located on Chromosome 17, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Neurofibromatosis, type 1
GTGTGTGTGGCTTCAAAAACATTGTTTGCTGTTTCTCTTTTCTCCACCATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTT...
GTGTGTGTGGCTTCAAAAACATTGTTTGCTGTTTCTCTTTTCTCCACCATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTT...
Task1_train_24009
A genomic change on Chromosome 17 affects NF1 (neurofibromin 1). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Neurofibromatosis, type 1
CCATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGT...
CCATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGT...
Task1_train_24010
The gene NF1 (neurofibromin 1) is located on Chromosome 17, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Neurofibromatosis, type 1
ATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTG...
ATTCTATAGGAATAAGATGGTAGAATACCTGACAGACTGGGTTATGGGAACATCAAACCAAGCAGCAGATGATGATGTAAAATGTCTTACAAGGTAAAAAAAGAATGACCTTCAAGTATTAGTGGGTTTTACTGTGAGAGTTATAACTACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTG...
Task1_train_24011
This variant impacts the gene NF1 (neurofibromin 1) on Chromosome 17. Is the change likely to result in a pathogenic outcome?
Pathogenic; Neurofibromatosis, type 1
TACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATT...
TACTTAATTACAGCTTTATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATT...
Task1_train_24012
Chromosome 17 houses a mutation in gene NF1 (neurofibromin 1). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Neurofibromatosis, type 1
TATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAG...
TATACTTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAG...
Task1_train_24013
Gene NF1 (neurofibromin 1) on Chromosome 17 is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; Neurofibromatosis, type 1
TTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAA...
TTGTATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAA...
Task1_train_24014
Here is a mutation in NF1 (neurofibromin 1) on Chromosome 17. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Neurofibromatosis, type 1
ATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAG...
ATTTTGTGTGTATTTAAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAG...
Task1_train_24015
A sequence alteration has been identified in NF1 (neurofibromin 1) on Chromosome 17. Is it disease-inducing or harmless?
Pathogenic; Neurofibromatosis, type 1
AAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCT...
AAACTTTTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCT...
Task1_train_24016
A sequence alteration has been identified in NF1 (neurofibromin 1) on Chromosome 17. Is it disease-inducing or harmless?
Pathogenic; Neurofibromatosis, type 1
TTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTA...
TTGAGATGTCAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTA...
Task1_train_24017
Given this variant in gene NF1 (neurofibromin 1) on Chromosome 17, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Neurofibromatosis, type 1
CAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTT...
CAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTT...
Task1_train_24018
Given this variant in gene NF1 (neurofibromin 1) on Chromosome 17, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Neurofibromatosis, type 1
CAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTT...
CAAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTT...
Task1_train_24019
Here’s a variant in NF1 (neurofibromin 1) located on Chromosome 17. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Neurofibromatosis, type 1
AAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTA...
AAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTA...
Task1_train_24020
An alteration has been detected in NF1 (neurofibromin 1) on Chromosome 17. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Neurofibromatosis, type 1
AAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTA...
AAACTTTTGTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTA...
Task1_train_24021
Consider this mutation in NF1 (neurofibromin 1) on Chromosome 17. Is this a benign change or a disease-causing variant?
Pathogenic; Neurofibromatosis, type 1
GTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACA...
GTGTTTGAAATATGTAAAGATGCTAATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACA...
Task1_train_24022
The gene NF1 (neurofibromin 1) is located on Chromosome 17, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Juvenile myelomonocytic leukemia
AATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTAT...
AATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTAT...
Task1_train_24023
A mutation in NF1 (neurofibromin 1), located on Chromosome 17, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Neurofibromatosis, type 1
AATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTAT...
AATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTAT...
Task1_train_24024
Here’s a variant in NF1 (neurofibromin 1) located on Chromosome 17. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Hereditary cancer-predisposing syndrome
AATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTAT...
AATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTAT...
Task1_train_24025
Chromosome 17 houses a mutation in gene NF1 (neurofibromin 1). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Cardiovascular phenotype
AATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTAT...
AATCTTTATTACTGCTTTTTTTTGACTGATAGACTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTAT...
Task1_train_24026
This genomic variant is located on Chromosome 17, within the NF1 (neurofibromin 1) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Neurofibromatosis, type 1
CTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTATGGACTGTATAATAAGCATTCACATATGTTTCTT...
CTTTCAGTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTATGGACTGTATAATAAGCATTCACATATGTTTCTT...
Task1_train_24027
This gene mutation involves NF1 (neurofibromin 1) on Chromosome 17. Is it associated with any clinical condition, or is it benign?
Pathogenic; Neurofibromatosis, type 1
GTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTATGGACTGTATAATAAGCATTCACATATGTTTCTTTGACCA...
GTAAAATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTATGGACTGTATAATAAGCATTCACATATGTTTCTTTGACCA...
Task1_train_24028
Here is a genetic alteration in NF1 (neurofibromin 1) on Chromosome 17. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Neurofibromatosis, type 1
ATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTATGGACTGTATAATAAGCATTCACATATGTTTCTTTGACCAAGCCT...
ATTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTATGGACTGTATAATAAGCATTCACATATGTTTCTTTGACCAAGCCT...
Task1_train_24029
Consider this mutation in NF1 (neurofibromin 1) on Chromosome 17. Is this a benign change or a disease-causing variant?
Pathogenic; Neurofibromatosis, type 1
TTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTATGGACTGTATAATAAGCATTCACATATGTTTCTTTGACCAAGCCTA...
TTAAATGTGAAAGAGTGATATGTTTGGGAAGTTAGTGTTGTCAGTTTATGAAGAATAGTCTACAGTTATTGGGAAATAAGATACATAAAGCCTCAGATTGCATTTGTGTTATGATTAGATAGATAAAGGTATTATTTGAGGAACTCATTGTGTTGAATCTTTTTAAGAAATAATTGATTTCCTGATTCAAGCACCAGAGACAGAAAAAAAAGGAAGTAATCAAGTCTGCTTTAATGATACTTATTGACACATATCAGAAAATGATTAAACACTATGGACTGTATAATAAGCATTCACATATGTTTCTTTGACCAAGCCTA...
Task1_train_24030
Chromosome 17 houses a mutation in gene NF1 (neurofibromin 1). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Café-au-lait macules with pulmonary stenosis
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24031
This gene mutation involves NF1 (neurofibromin 1) on Chromosome 17. Is it associated with any clinical condition, or is it benign?
Pathogenic; Neurofibromatosis, type 1
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24032
A genomic change on Chromosome 17 affects NF1 (neurofibromin 1). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Juvenile myelomonocytic leukemia
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24033
A mutation found in NF1 (neurofibromin 1) on Chromosome 17 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Neurofibromatosis, familial spinal
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24034
Gene NF1 (neurofibromin 1) on Chromosome 17 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Neurofibromatosis-Noonan syndrome
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24035
A variant affecting Chromosome 17, within the gene NF1 (neurofibromin 1), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Café-au-lait macules with pulmonary stenosis
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24036
The gene NF1 (neurofibromin 1) on Chromosome 17 contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Neurofibromatosis, type 1
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24037
A mutation found in NF1 (neurofibromin 1) on Chromosome 17 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Neurofibromatosis-Noonan syndrome
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24038
This alteration in NF1 (neurofibromin 1) on Chromosome 17 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Neurofibromatosis, type 1
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24039
A mutation found in NF1 (neurofibromin 1) on Chromosome 17 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Hereditary cancer-predisposing syndrome
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24040
This genomic variant is located on Chromosome 17, within the NF1 (neurofibromin 1) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Cardiovascular phenotype
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24041
The gene NF1 (neurofibromin 1) on Chromosome 17 contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Neurofibromatosis, type 1
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
ATGTCTCTCTCTTAATTTAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCAC...
Task1_train_24042
Gene NF1 (neurofibromin 1), found on Chromosome 17, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Neurofibromatosis, type 1
TAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCACACCAGCTACCTTTCTGT...
TAATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCACACCAGCTACCTTTCTGT...
Task1_train_24043
This alteration in NF1 (neurofibromin 1) on Chromosome 17 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Neurofibromatosis, type 1
ATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCACACCAGCTACCTTTCTGTCC...
ATGAAAAATTTTCCTAAAATCACATCATTCTTAATACATGCTAAAACGTTGAGACGGGTTGTTGTTCCTTTCCAGTGTTAAAAGGCTATTTGCTTTTTAGTGTACCAAAACTGATTTCAGTTATAGTAAATTATGACTAATAAGGTAATCTGTCCTTGTTAACAAGCCTGTATTTGTTATACCTGTACTTAAAGTAAAATTCAAACTCCTTACCCTGTCCTACAAGGCTCTACCTGATCTGGGCCCTACCTCATCTCTAACATCATCTTATGCTATTTTCTTTCTTGTTCACCAGAGCCACACCAGCTACCTTTCTGTCC...
Task1_train_24044
A variant affecting Chromosome 17, within the gene NF1 (neurofibromin 1), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Neurofibromatosis, type 1
TATTTTCTTTCTTGTTCACCAGAGCCACACCAGCTACCTTTCTGTCCCTCCTTGTTAGACTTATTTCTGCTTTAGAGCACCCTTGCTGCTGCCACCACCTGAAATGCTTCTCTTCTGGTATTTTATTTTGGTGAGAACACCTGGCATGAGATCTACCCTCTAACAGATTTTTAAGTGTATAATACAGTATTGCTGTCTGTAGGCACAATGCTGCACAGCAGATCTCTAGAACTTACCTTGTATAACTGAAATTTTATACTCATTGATTAGCAACAGCCCCAAATTATTGAAACCTCCTTGAAGCCTAAATTTCAGAAATG...
TATTTTCTTTCTTGTTCACCAGAGCCACACCAGCTACCTTTCTGTCCCTCCTTGTTAGACTTATTTCTGCTTTAGAGCACCCTTGCTGCTGCCACCACCTGAAATGCTTCTCTTCTGGTATTTTATTTTGGTGAGAACACCTGGCATGAGATCTACCCTCTAACAGATTTTTAAGTGTATAATACAGTATTGCTGTCTGTAGGCACAATGCTGCACAGCAGATCTCTAGAACTTACCTTGTATAACTGAAATTTTATACTCATTGATTAGCAACAGCCCCAAATTATTGAAACCTCCTTGAAGCCTAAATTTCAGAAATG...
Task1_train_24045
Gene NF1 (neurofibromin 1) on Chromosome 17 is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; Hereditary cancer-predisposing syndrome
TATTTTCTTTCTTGTTCACCAGAGCCACACCAGCTACCTTTCTGTCCCTCCTTGTTAGACTTATTTCTGCTTTAGAGCACCCTTGCTGCTGCCACCACCTGAAATGCTTCTCTTCTGGTATTTTATTTTGGTGAGAACACCTGGCATGAGATCTACCCTCTAACAGATTTTTAAGTGTATAATACAGTATTGCTGTCTGTAGGCACAATGCTGCACAGCAGATCTCTAGAACTTACCTTGTATAACTGAAATTTTATACTCATTGATTAGCAACAGCCCCAAATTATTGAAACCTCCTTGAAGCCTAAATTTCAGAAATG...
TATTTTCTTTCTTGTTCACCAGAGCCACACCAGCTACCTTTCTGTCCCTCCTTGTTAGACTTATTTCTGCTTTAGAGCACCCTTGCTGCTGCCACCACCTGAAATGCTTCTCTTCTGGTATTTTATTTTGGTGAGAACACCTGGCATGAGATCTACCCTCTAACAGATTTTTAAGTGTATAATACAGTATTGCTGTCTGTAGGCACAATGCTGCACAGCAGATCTCTAGAACTTACCTTGTATAACTGAAATTTTATACTCATTGATTAGCAACAGCCCCAAATTATTGAAACCTCCTTGAAGCCTAAATTTCAGAAATG...
Task1_train_24046
The gene NF1 (neurofibromin 1) on Chromosome 17 contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Cardiovascular phenotype
TATTTTCTTTCTTGTTCACCAGAGCCACACCAGCTACCTTTCTGTCCCTCCTTGTTAGACTTATTTCTGCTTTAGAGCACCCTTGCTGCTGCCACCACCTGAAATGCTTCTCTTCTGGTATTTTATTTTGGTGAGAACACCTGGCATGAGATCTACCCTCTAACAGATTTTTAAGTGTATAATACAGTATTGCTGTCTGTAGGCACAATGCTGCACAGCAGATCTCTAGAACTTACCTTGTATAACTGAAATTTTATACTCATTGATTAGCAACAGCCCCAAATTATTGAAACCTCCTTGAAGCCTAAATTTCAGAAATG...
TATTTTCTTTCTTGTTCACCAGAGCCACACCAGCTACCTTTCTGTCCCTCCTTGTTAGACTTATTTCTGCTTTAGAGCACCCTTGCTGCTGCCACCACCTGAAATGCTTCTCTTCTGGTATTTTATTTTGGTGAGAACACCTGGCATGAGATCTACCCTCTAACAGATTTTTAAGTGTATAATACAGTATTGCTGTCTGTAGGCACAATGCTGCACAGCAGATCTCTAGAACTTACCTTGTATAACTGAAATTTTATACTCATTGATTAGCAACAGCCCCAAATTATTGAAACCTCCTTGAAGCCTAAATTTCAGAAATG...
Task1_train_24047
A mutation in NF1 (neurofibromin 1), located on Chromosome 17, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Neurofibromatosis, type 1
ATAAGGTCAAGAGATCTAGACCATGCCGGCCAACATGGTGAAACCTTGTCTCTACTAAAAATACAAAAATTACCTGGGCGTGGTGGTGGTGCGCCTGTAGTCCCATCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCCGGCAACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAGCAATACTGATTGGATATGGGGAATAATGAAGTAGAGCAGGAAAAAGTGACATCAGAGATGGCCTGAATGATGTGATTAAGAAAG...
ATAAGGTCAAGAGATCTAGACCATGCCGGCCAACATGGTGAAACCTTGTCTCTACTAAAAATACAAAAATTACCTGGGCGTGGTGGTGGTGCGCCTGTAGTCCCATCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCCGGCAACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAGCAATACTGATTGGATATGGGGAATAATGAAGTAGAGCAGGAAAAAGTGACATCAGAGATGGCCTGAATGATGTGATTAAGAAAG...
Task1_train_24048
The gene NF1 (neurofibromin 1) is located on Chromosome 17, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Neurofibromatosis, type 1
GTTTCGAACTCCTAGCCTCAAGTGATCTGCCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAGAGAATTGTCTAAGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTA...
GTTTCGAACTCCTAGCCTCAAGTGATCTGCCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAGAGAATTGTCTAAGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTA...
Task1_train_24049
A variant has been detected on Chromosome 17 in NF1 (neurofibromin 1). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Neurofibromatosis, type 1
TTCGAACTCCTAGCCTCAAGTGATCTGCCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAGAGAATTGTCTAAGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGC...
TTCGAACTCCTAGCCTCAAGTGATCTGCCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAGAGAATTGTCTAAGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGC...
Task1_train_24050
Mutation context: Chromosome 17, Gene NF1 (neurofibromin 1). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Neurofibromatosis, type 1
AGCCTCAAGTGATCTGCCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAGAGAATTGTCTAAGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTG...
AGCCTCAAGTGATCTGCCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAGAGAATTGTCTAAGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTG...
Task1_train_24051
This mutation is located in gene NF1 (neurofibromin 1) on Chromosome 17. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Neurofibromatosis, type 1
AGCCTCAAGTGATCTGCCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAGAGAATTGTCTAAGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTG...
AGCCTCAAGTGATCTGCCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAGAGAATTGTCTAAGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTG...
Task1_train_24052
A variant found in Chromosome 17 affects NF1 (neurofibromin 1). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Neurofibromatosis, type 1
GAGAATTGTCTAAGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGC...
GAGAATTGTCTAAGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGC...
Task1_train_24053
An alteration has been detected in NF1 (neurofibromin 1) on Chromosome 17. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Café-au-lait macules with pulmonary stenosis
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24054
Gene NF1 (neurofibromin 1), found on Chromosome 17, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Juvenile myelomonocytic leukemia
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24055
A genetic alteration is present in NF1 (neurofibromin 1) on Chromosome 17. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Neurofibromatosis, type 1
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24056
With a mutation on Chromosome 17 in gene NF1 (neurofibromin 1), classify this variant as benign or pathogenic. Include the disease if it's pathogenic.
Pathogenic; Hereditary cancer-predisposing syndrome
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24057
A mutation in NF1 (neurofibromin 1), located on Chromosome 17, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Cardiovascular phenotype
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24058
A variant has been detected on Chromosome 17 in NF1 (neurofibromin 1). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Axillary freckling
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24059
This genomic variant is located on Chromosome 17, within the NF1 (neurofibromin 1) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Cafe au lait spots, multiple
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24060
The gene NF1 (neurofibromin 1) on Chromosome 17 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Optic nerve glioma
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24061
A variant has been detected on Chromosome 17 in NF1 (neurofibromin 1). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Neurofibroma
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24062
Here is a genetic alteration in NF1 (neurofibromin 1) on Chromosome 17. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Juvenile myelomonocytic leukemia
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24063
Gene NF1 (neurofibromin 1) on Chromosome 17 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Café-au-lait macules with pulmonary stenosis
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24064
This variant lies on Chromosome 17 and affects the gene NF1 (neurofibromin 1). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Neurofibromatosis-Noonan syndrome
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24065
Located on Chromosome 17, this mutation impacts NF1 (neurofibromin 1). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Neurofibromatosis, type 1
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24066
Assess the clinical impact of this variant on gene NF1 (neurofibromin 1), found on Chromosome 17. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Neurofibromatosis, familial spinal
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24067
This alteration in NF1 (neurofibromin 1) on Chromosome 17 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Pheochromocytoma
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
AGATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAG...
Task1_train_24068
A mutation in NF1 (neurofibromin 1), located on Chromosome 17, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Neurofibromatosis, type 1
GATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAGT...
GATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAGT...
Task1_train_24069
Given this variant in gene NF1 (neurofibromin 1) on Chromosome 17, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Cardiovascular phenotype
GATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAGT...
GATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAGT...
Task1_train_24070
The following genetic variant occurs in NF1 (neurofibromin 1) on Chromosome 17. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Hereditary cancer-predisposing syndrome
GATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAGT...
GATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAGT...
Task1_train_24071
Gene NF1 (neurofibromin 1) on Chromosome 17 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Juvenile myelomonocytic leukemia
GATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAGT...
GATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAGT...
Task1_train_24072
The gene NF1 (neurofibromin 1), on Chromosome 17, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; Neurofibromatosis, type 1
GATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAGT...
GATTAAAATTTGGGAGTTTTAGAAAACCACTCAGTAGCAATGATGGTCTATGAATATTCTAAAATTATGTGAAGAATTTTGTGTGTGTGAATGCATACATTCATTTTTCTAACCTTTATCAGATTTCAAAGAGGTTCCTCGTCCCCAGAAGGTTCAACACCGTACTGGAATAGTCAAAGCACTGGAATTTTTTCTTAATTTTACATCTTTCTATAGTTTTAGCTAAAACTTCTGTATCTAATTCTAAATGTATATATTTGAGCTAAAAATAAATGGTATTTAGGTTTTAAAGCCATTCTAATAAAGCAGCTATATTTAGT...
Task1_train_24073
The gene NF1 (neurofibromin 1), on Chromosome 17, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; Neurofibromatosis, type 1
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
Task1_train_24074
The variant affects gene NF1 (neurofibromin 1), which is on Chromosome 17. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Cardiovascular phenotype
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
Task1_train_24075
Here’s a variant in NF1 (neurofibromin 1) located on Chromosome 17. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Hereditary cancer-predisposing syndrome
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
Task1_train_24076
A variant affecting Chromosome 17, within the gene NF1 (neurofibromin 1), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Neurofibromatosis, type 1
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
Task1_train_24077
Mutation context: Chromosome 17, Gene NF1 (neurofibromin 1). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Cardiovascular phenotype
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
Task1_train_24078
This genomic variant is located on Chromosome 17, within the NF1 (neurofibromin 1) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Hereditary cancer-predisposing syndrome
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
TTATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTA...
Task1_train_24079
The following genetic variant occurs in NF1 (neurofibromin 1) on Chromosome 17. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Neurofibromatosis, type 1
TATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAG...
TATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAG...
Task1_train_24080
This alteration in NF1 (neurofibromin 1) on Chromosome 17 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Juvenile myelomonocytic leukemia
TATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAG...
TATAAGCAGTGATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAG...
Task1_train_24081
A genomic change on Chromosome 17 affects NF1 (neurofibromin 1). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Hereditary cancer-predisposing syndrome
ATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGC...
ATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGC...
Task1_train_24082
Given a variant located on Chromosome 17 and affecting NF1 (neurofibromin 1), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Cardiovascular phenotype
ATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGC...
ATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGC...
Task1_train_24083
Gene NF1 (neurofibromin 1) on Chromosome 17 is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; Neurofibromatosis, type 1
ATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGC...
ATAACACATTTAAAATGTGGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGC...
Task1_train_24084
This variant lies on Chromosome 17 and affects the gene NF1 (neurofibromin 1). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Neurofibromatosis, type 1
GGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGAT...
GGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGAT...
Task1_train_24085
The following genetic variant occurs in NF1 (neurofibromin 1) on Chromosome 17. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Neurofibromatosis, type 1
GGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGAT...
GGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGAT...
Task1_train_24086
This variant lies on Chromosome 17 and affects the gene NF1 (neurofibromin 1). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Cardiovascular phenotype
GGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGAT...
GGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGAT...
Task1_train_24087
Here is a mutation in NF1 (neurofibromin 1) on Chromosome 17. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Hereditary cancer-predisposing syndrome
GGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGAT...
GGACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGAT...
Task1_train_24088
Here is a variant affecting NF1 (neurofibromin 1) on Chromosome 17. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Neurofibromatosis, type 1
ACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGATTA...
ACTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGATTA...
Task1_train_24089
Mutation context: Chromosome 17, Gene NF1 (neurofibromin 1). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Neurofibromatosis, type 1
CTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGATTAA...
CTGCATGAAGCACTACATTGAACAAGATGAAGTGAAATAATCCCCATTTTTTCCAGAGTTAATCTGGAGTCAGCCTGTCATAATTTGTGTCATAATTTCCTGTCATAAATTATGACAGGAAATATTTATTGAAGCATTGTGAAAAAAATAGCTACGTGATATTCCGCATGTAAATCTGGGTCCCCTCCCACCAATATCCTTTGAAATGAAGGTTTATCCTTGACATCACAGAATATTGAGTGGAATGCTACAGTTTTGTAGTCACTGCTACTTTAAACAGCAGTTTAGCCGCACTAAGCAAGAATAGCTGTAGAGATTAA...
Task1_train_24090
This mutation occurs in NF1 (neurofibromin 1) on Chromosome 17. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Hereditary cancer-predisposing syndrome
GCGTTTCCCTCAGAACAGCATCGGTGCAGTAGGAAGTGCCATGTTCCTCAGATTTATCAATCCTGCCATTGTCTCACCGTATGAAGCAGGGATTTTAGATAAAAAGCCACCACCTAGAATCGAAAGGGGCTTGAAGTTAATGTCAAAGGTGAATTATTTTGATAATCTAGCTATCTTAAATTCCCCTTCCAACTAAATTTTCAGCTTTTCTTACAGTACTTCCTCTTACATTTATATTTGAAATACCCTATGGTTTTCAGTTATGTGCTTTTGTTTTATTTGTTTATATTACAAAGGAATTCATTAGTTAGGTACCTGAT...
GCGTTTCCCTCAGAACAGCATCGGTGCAGTAGGAAGTGCCATGTTCCTCAGATTTATCAATCCTGCCATTGTCTCACCGTATGAAGCAGGGATTTTAGATAAAAAGCCACCACCTAGAATCGAAAGGGGCTTGAAGTTAATGTCAAAGGTGAATTATTTTGATAATCTAGCTATCTTAAATTCCCCTTCCAACTAAATTTTCAGCTTTTCTTACAGTACTTCCTCTTACATTTATATTTGAAATACCCTATGGTTTTCAGTTATGTGCTTTTGTTTTATTTGTTTATATTACAAAGGAATTCATTAGTTAGGTACCTGAT...
Task1_train_24091
Given this context: Chromosome 17, gene NF1 (neurofibromin 1) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; Cardiovascular phenotype
GCGTTTCCCTCAGAACAGCATCGGTGCAGTAGGAAGTGCCATGTTCCTCAGATTTATCAATCCTGCCATTGTCTCACCGTATGAAGCAGGGATTTTAGATAAAAAGCCACCACCTAGAATCGAAAGGGGCTTGAAGTTAATGTCAAAGGTGAATTATTTTGATAATCTAGCTATCTTAAATTCCCCTTCCAACTAAATTTTCAGCTTTTCTTACAGTACTTCCTCTTACATTTATATTTGAAATACCCTATGGTTTTCAGTTATGTGCTTTTGTTTTATTTGTTTATATTACAAAGGAATTCATTAGTTAGGTACCTGAT...
GCGTTTCCCTCAGAACAGCATCGGTGCAGTAGGAAGTGCCATGTTCCTCAGATTTATCAATCCTGCCATTGTCTCACCGTATGAAGCAGGGATTTTAGATAAAAAGCCACCACCTAGAATCGAAAGGGGCTTGAAGTTAATGTCAAAGGTGAATTATTTTGATAATCTAGCTATCTTAAATTCCCCTTCCAACTAAATTTTCAGCTTTTCTTACAGTACTTCCTCTTACATTTATATTTGAAATACCCTATGGTTTTCAGTTATGTGCTTTTGTTTTATTTGTTTATATTACAAAGGAATTCATTAGTTAGGTACCTGAT...
Task1_train_24092
Given a variant located on Chromosome 17 and affecting NF1 (neurofibromin 1), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Neurofibromatosis, type 1
GCGTTTCCCTCAGAACAGCATCGGTGCAGTAGGAAGTGCCATGTTCCTCAGATTTATCAATCCTGCCATTGTCTCACCGTATGAAGCAGGGATTTTAGATAAAAAGCCACCACCTAGAATCGAAAGGGGCTTGAAGTTAATGTCAAAGGTGAATTATTTTGATAATCTAGCTATCTTAAATTCCCCTTCCAACTAAATTTTCAGCTTTTCTTACAGTACTTCCTCTTACATTTATATTTGAAATACCCTATGGTTTTCAGTTATGTGCTTTTGTTTTATTTGTTTATATTACAAAGGAATTCATTAGTTAGGTACCTGAT...
GCGTTTCCCTCAGAACAGCATCGGTGCAGTAGGAAGTGCCATGTTCCTCAGATTTATCAATCCTGCCATTGTCTCACCGTATGAAGCAGGGATTTTAGATAAAAAGCCACCACCTAGAATCGAAAGGGGCTTGAAGTTAATGTCAAAGGTGAATTATTTTGATAATCTAGCTATCTTAAATTCCCCTTCCAACTAAATTTTCAGCTTTTCTTACAGTACTTCCTCTTACATTTATATTTGAAATACCCTATGGTTTTCAGTTATGTGCTTTTGTTTTATTTGTTTATATTACAAAGGAATTCATTAGTTAGGTACCTGAT...
Task1_train_24093
Gene NF1 (neurofibromin 1) on Chromosome 17 is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; Neurofibromatosis, type 1
AAGTGCCATGTTCCTCAGATTTATCAATCCTGCCATTGTCTCACCGTATGAAGCAGGGATTTTAGATAAAAAGCCACCACCTAGAATCGAAAGGGGCTTGAAGTTAATGTCAAAGGTGAATTATTTTGATAATCTAGCTATCTTAAATTCCCCTTCCAACTAAATTTTCAGCTTTTCTTACAGTACTTCCTCTTACATTTATATTTGAAATACCCTATGGTTTTCAGTTATGTGCTTTTGTTTTATTTGTTTATATTACAAAGGAATTCATTAGTTAGGTACCTGATGGACCTTATTTTCATGATAAAACATTTTATTAT...
AAGTGCCATGTTCCTCAGATTTATCAATCCTGCCATTGTCTCACCGTATGAAGCAGGGATTTTAGATAAAAAGCCACCACCTAGAATCGAAAGGGGCTTGAAGTTAATGTCAAAGGTGAATTATTTTGATAATCTAGCTATCTTAAATTCCCCTTCCAACTAAATTTTCAGCTTTTCTTACAGTACTTCCTCTTACATTTATATTTGAAATACCCTATGGTTTTCAGTTATGTGCTTTTGTTTTATTTGTTTATATTACAAAGGAATTCATTAGTTAGGTACCTGATGGACCTTATTTTCATGATAAAACATTTTATTAT...
Task1_train_24094
A genomic change on Chromosome 17 affects NF1 (neurofibromin 1). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Neurofibromatosis, type 1
AGTTATTGGTCTATCTGTAAAGTAGGGATAAACTCTTTGCCTGAGTTGTTTTTAGAGAAAAAAATGAGATAATTCATAAGAAAGCGCTTTGTAAATTTATGTCTGGAATTCTGCTTTTCATGCAGTGTGAATCTAATTGATCCTCATCATCTAAGCTAGCCTTGTACAACTCTCTCTTCCAGTTTATCATCATTGTAGTTGTTACTGACTTTTTTTCTGTTAGAGAAATTGGAGTTGAAAAGGTATATTGCTGAATGACAAGCCATGTTGGAAAGAGAGTGAATGTCAGCATAGGATTCATATTCTGGCACTCTGTGTAC...
AGTTATTGGTCTATCTGTAAAGTAGGGATAAACTCTTTGCCTGAGTTGTTTTTAGAGAAAAAAATGAGATAATTCATAAGAAAGCGCTTTGTAAATTTATGTCTGGAATTCTGCTTTTCATGCAGTGTGAATCTAATTGATCCTCATCATCTAAGCTAGCCTTGTACAACTCTCTCTTCCAGTTTATCATCATTGTAGTTGTTACTGACTTTTTTTCTGTTAGAGAAATTGGAGTTGAAAAGGTATATTGCTGAATGACAAGCCATGTTGGAAAGAGAGTGAATGTCAGCATAGGATTCATATTCTGGCACTCTGTGTAC...
Task1_train_24095
This variant affects gene NF1 (neurofibromin 1) located on Chromosome 17. Evaluate its biological effect and specify any disease association.
Pathogenic; Neurofibromatosis, type 1
CTCTTTGCCTGAGTTGTTTTTAGAGAAAAAAATGAGATAATTCATAAGAAAGCGCTTTGTAAATTTATGTCTGGAATTCTGCTTTTCATGCAGTGTGAATCTAATTGATCCTCATCATCTAAGCTAGCCTTGTACAACTCTCTCTTCCAGTTTATCATCATTGTAGTTGTTACTGACTTTTTTTCTGTTAGAGAAATTGGAGTTGAAAAGGTATATTGCTGAATGACAAGCCATGTTGGAAAGAGAGTGAATGTCAGCATAGGATTCATATTCTGGCACTCTGTGTACCCATACAAAGTTAAAAGGATCAAAGTTTTAAT...
CTCTTTGCCTGAGTTGTTTTTAGAGAAAAAAATGAGATAATTCATAAGAAAGCGCTTTGTAAATTTATGTCTGGAATTCTGCTTTTCATGCAGTGTGAATCTAATTGATCCTCATCATCTAAGCTAGCCTTGTACAACTCTCTCTTCCAGTTTATCATCATTGTAGTTGTTACTGACTTTTTTTCTGTTAGAGAAATTGGAGTTGAAAAGGTATATTGCTGAATGACAAGCCATGTTGGAAAGAGAGTGAATGTCAGCATAGGATTCATATTCTGGCACTCTGTGTACCCATACAAAGTTAAAAGGATCAAAGTTTTAAT...
Task1_train_24096
This variant impacts the gene NF1 (neurofibromin 1) on Chromosome 17. Is the change likely to result in a pathogenic outcome?
Pathogenic; Neurofibromatosis, type 1
ATATTAACCAGGTGTGATGGTACGCACCTGTGGTCCCAGCTACCTGGGAGGCTGAGGTGGGAGGATTGCTTGAGGATGCAGTGAACTGTGATTGCACCAGTGCATTTCCAGCCTAGGTGACAGAATGAGACCTTGTCTATAAATAAAGAAATAAGTAAAAATATAAATAAGTAAAAAGAAATATAAGTAAATATAAATATAAATAAATATAAATATAAAAATGAATGAATCAAAACAGTTTTTAAATTTGACATCACTGAGGACATCCTAGCCATTTTTCTAGAAAAATATTTTTATTATTCCTTTTTTCTGAGATCCTA...
ATATTAACCAGGTGTGATGGTACGCACCTGTGGTCCCAGCTACCTGGGAGGCTGAGGTGGGAGGATTGCTTGAGGATGCAGTGAACTGTGATTGCACCAGTGCATTTCCAGCCTAGGTGACAGAATGAGACCTTGTCTATAAATAAAGAAATAAGTAAAAATATAAATAAGTAAAAAGAAATATAAGTAAATATAAATATAAATAAATATAAATATAAAAATGAATGAATCAAAACAGTTTTTAAATTTGACATCACTGAGGACATCCTAGCCATTTTTCTAGAAAAATATTTTTATTATTCCTTTTTTCTGAGATCCTA...
Task1_train_24097
A sequence alteration has been identified in NF1 (neurofibromin 1) on Chromosome 17. Is it disease-inducing or harmless?
Pathogenic; Neurofibromatosis, type 1
TGTCTTAATAACAGTATTTTCTCTGCATTTCCTTTGATAAGTGATTACTTTCTACCTCATATCTTCTATCTTGAAATATTTGTGTTGTTTTAAAATCATTTGACTTGTCATATTTTTATCTTATTTTCTCCCAACAAGATTAAAAATTCTGAGGTGAAGTTTTTTATTGATACATGATAATTTGTACATATTAATGGAGTATGTGTGATTTTTTTGGTTTTTTTTGTTTTTGTTTTTGTTGGAATCTCGCTCTATCGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAAACTCCCCTCCCAGGTTCAAGCA...
TGTCTTAATAACAGTATTTTCTCTGCATTTCCTTTGATAAGTGATTACTTTCTACCTCATATCTTCTATCTTGAAATATTTGTGTTGTTTTAAAATCATTTGACTTGTCATATTTTTATCTTATTTTCTCCCAACAAGATTAAAAATTCTGAGGTGAAGTTTTTTATTGATACATGATAATTTGTACATATTAATGGAGTATGTGTGATTTTTTTGGTTTTTTTTGTTTTTGTTTTTGTTGGAATCTCGCTCTATCGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAAACTCCCCTCCCAGGTTCAAGCA...
Task1_train_24098
This variant impacts the gene NF1 (neurofibromin 1) on Chromosome 17. Is the change likely to result in a pathogenic outcome?
Pathogenic; Neurofibromatosis, type 1
TTTTCTCTGCATTTCCTTTGATAAGTGATTACTTTCTACCTCATATCTTCTATCTTGAAATATTTGTGTTGTTTTAAAATCATTTGACTTGTCATATTTTTATCTTATTTTCTCCCAACAAGATTAAAAATTCTGAGGTGAAGTTTTTTATTGATACATGATAATTTGTACATATTAATGGAGTATGTGTGATTTTTTTGGTTTTTTTTGTTTTTGTTTTTGTTGGAATCTCGCTCTATCGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAAACTCCCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGC...
TTTTCTCTGCATTTCCTTTGATAAGTGATTACTTTCTACCTCATATCTTCTATCTTGAAATATTTGTGTTGTTTTAAAATCATTTGACTTGTCATATTTTTATCTTATTTTCTCCCAACAAGATTAAAAATTCTGAGGTGAAGTTTTTTATTGATACATGATAATTTGTACATATTAATGGAGTATGTGTGATTTTTTTGGTTTTTTTTGTTTTTGTTTTTGTTGGAATCTCGCTCTATCGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAAACTCCCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGC...
Task1_train_24099
A variant affecting Chromosome 17, within the gene NF1 (neurofibromin 1), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Neurofibromatosis, type 1
TTTTCTCTGCATTTCCTTTGATAAGTGATTACTTTCTACCTCATATCTTCTATCTTGAAATATTTGTGTTGTTTTAAAATCATTTGACTTGTCATATTTTTATCTTATTTTCTCCCAACAAGATTAAAAATTCTGAGGTGAAGTTTTTTATTGATACATGATAATTTGTACATATTAATGGAGTATGTGTGATTTTTTTGGTTTTTTTTGTTTTTGTTTTTGTTGGAATCTCGCTCTATCGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAAACTCCCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGC...
TTTTCTCTGCATTTCCTTTGATAAGTGATTACTTTCTACCTCATATCTTCTATCTTGAAATATTTGTGTTGTTTTAAAATCATTTGACTTGTCATATTTTTATCTTATTTTCTCCCAACAAGATTAAAAATTCTGAGGTGAAGTTTTTTATTGATACATGATAATTTGTACATATTAATGGAGTATGTGTGATTTTTTTGGTTTTTTTTGTTTTTGTTTTTGTTGGAATCTCGCTCTATCGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAAACTCCCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGC...