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Nucleosomes are thought to carry epigenetically inherited information in the form of covalent modifications of their core histones .	Nucleosomes are thought to carry epigenetically inherited information , as modifications of their core histones .
Nucleosomes form the fundamental repeating units of eukaryotic chromatin , which is used to pack the large eukaryotic genomes into the nucleus while still ensuring appropriate access to it ( in mammalian cells approximately 2 m of linear DNA have to be packed into a nucleus of roughly 10 µm diameter ) .	In mammalian cells about two metres of linear DNA have to be packed into a nucleus of roughly 10 µm diameter .
A nucleosome is the basic unit of DNA packaging in eukaryotes , consisting of a segment of DNA wound in sequence around eight histone protein cores .	They consist of a segment of DNA wound around a histone protein core .
Nucleosomes are folded through a series of successively higher order structures to eventually form a chromosome ; this both compacts DNA and creates an added layer of regulatory control , which ensures correct gene expression .	Nucleosomes are folded , in a series of higher order structures , to form a chromosome .
`` Pon de Replay '' is the debut single recorded by Barbadian recording artist Rihanna , from her debut studio album Music of the Sun ( 2005 ) .	`` Pon de Replay '' is the first single released in 2005 off the album Music of the Sun by pop singer Rihanna .
It was written and produced by Vada Nobles , Alisha `` M'Jestie '' Brooks , Carl Sturken and Evan Rogers .	`` Pon de Replay '' ( `` Play It Again '' ) is a song written by Vada Nobles , Carl Sturken , Evan Rogers , and Alisha Brooks for pop singer Rihanna 's debut album , Music of the Sun ( 2005 ) .
However , the song was less successful in other territories , peaking at number 15 in The Netherlands and number 18 in France and Spain , respectively .	The song peaked at number 2 on the U.S. Billboard Hot 100 , becoming her first Top 5 single ; it also peaked at number 1 in New Zealand , number 2 in the UK and at number 6 and number 7 in Australia and Canada , respectively .
`` Pon de Replay '' is a dance-pop and R&B song , which infuses a reggae style .	Pon de Replay was also a major dance hit topping both the Hot Dance Music\/Club Play and the Dance Radio Airplay chart for 2 weeks .
The seamount chain , containing over 80 identified undersea volcanoes , stretches over 5,800 kilometres ( 3,600 mi ) from the Aleutian Trench in the far northwest Pacific to the Loʻihi seamount , the youngest volcano in the chain , which lies about 35 kilometres ( 22 mi ) southeast of the Island of Hawaiʻi .	The seamount chain , with over 80 identified undersea volcanoes , stretches over 5,800 kilometres ( 3,600 mi ) from the Aleutian Trench in the far northwest Pacific to the Loʻihi seamount , the youngest volcano in the chain , which lies about 35 kilometres ( 22 mi ) southeast of the Island of Hawaiʻi .
However , recent research shows that the hotspot itself may have moved with time .	Recent research shows that the hotspot itself may have moved with time .
In 1963 , geologist John Tuzo Wilson hypothesized the origins of the Hawaiian-Emperor seamount chain , explaining that they were created by a hotspot of volcanic activity that was essentially stationary as the Pacific tectonic plate drifted in a northwesterly direction , leaving a trail of increasingly eroded volcanic ...	In 1963 , geologist John Tuzo Wilson explained that the Hawaiian-Emperor seamount chain was created by a hotspot of volcanic activity that stood as the Pacific tectonic plate moved over it .
Some evidence comes from analysis of the orientation of the ancient magnetic field preserved by magnetite in ancient lava flows sampled at four seamounts ( Tarduno et al. , 2003 ) : this evidence from paleomagnetism shows a more complex history than the commonly accepted view of a stationary hotspot .	Some evidence comes from analysis of the orientation of the ancient magnetic field preserved by magnetite in ancient lava flows sampled at four seamounts .
An otherwise inexplicable kink in the chain marks a shift in the movement of the Pacific plate some 47 million years ago , from a northward to a more northwesterly direction , and the kink has been presented in geology texts as an example of how a tectonic plate can shift direction comparatively suddenly .	A `` bend '' or `` V '' in the chain marks a shift in the movement of the Pacific plate some 47 million years ago , from a northward to a more northwesterly direction .
It is composed of the Hawaiian ridge , consisting of the islands of the Hawaiian chain northwest to Kure Atoll , and the Emperor Seamounts : together they form a vast underwater mountain region of islands and intervening seamounts , atolls , shallows , banks and reefs along a line trending southeast to northwest beneat...	The Hawaiian-Emperor seamount chain is the Hawaiian Islands and the Emperor Seamounts : together they form a vast underwater mountain region of islands seamounts , atolls , shallows , banks and reefs .
Frankfurt was one of the most important cities in the following Holy Roman Empire .	Frankfurt was one of the most important cities of the Holy Roman Empire , and its emperors were crowned here .
Frankfurt was historically a Protestant-dominated city .	Frankfurt is a very international city .
Frankfurt is also a center for commerce , culture , education , tourism and web traffic .	Frankfurt is an important center for traffic and for the financial business .
It is home to the European Central Bank , Deutsche Bundesbank , Frankfurt Stock Exchange and several large commercial banks .	Frankfurt is the seat of the European Central Bank , the German Federal Bank ( Bundesbank ) and of the biggest German banks , and it has an important stock exchange where shares of German companies are traded .
Outside of his native country , Vasil Bykaŭ is the most widely read Belarusian writer .	Vasil Bykaŭ is the most widely read Belarusian writer outside of Belarus .
In 1980 he was awarded the honorific title of People 's Writer of the Belarusian SSR .	In 1980 he was awarded the title of People 's Writer of the Belarusian SSR .
Vasil Uładzimiravič Bykaŭ ( Belarusian : Васі́ль Уладзі́міравіч Бы́каў , ( June 19 , 1924 - June 22 , 2003 ) was a prolific author of novels and novellas about World War II , is a monumental figure in Belarusian literature and civic thought .	Vasil Uładzimiravič Bykaŭ ( June 19 , 1924 - June 22 , 2003 ) was an author of many novels and novellas about World War II .
The writer 's talent and the moral courage that permeates his writings earned him endorsements for the Nobel Prize nomination from , among others , Nobel Prize laureates Joseph Brodsky and Czesław Miłosz .	The writer 's talent earned him endorsements for the Nobel Prize nomination from , among others , Nobel Prize laureates Joseph Brodsky and Czesław Miłosz .
For years after the war he continued to serve , returning to the USSR only in the mid-1950s .	He returned to the USSR only in the mid-1950s .
Old Faithful was named in 1870 during the Washburn-Langford-Doane Expedition and was the first geyser in the park to receive a name .	Old Faithful was named in 1870 during the Washburn-Langford-Doane Expedition and was the first geyser in the park to get a name .
Harry Woodward first described a mathematical relationship between the duration and intervals of the eruptions ( 1938 ) .	Harry M. Woodward first described a mathematical relationship between the duration and intervals of the eruptions ( 1938 ) .
With a margin of error of 10 minutes , Old Faithful will erupt 65 minutes after an eruption lasting less than 2.5 minutes or 91 minutes after an eruption lasting more than 2.5 minutes .	With an error of 10 minutes , Old Faithful will erupt 65 minutes after an eruption lasting less than 2.5 minutes or 92 minutes after an eruption lasting more than 2.5 minutes .
Old Faithful is a cone geyser located in Wyoming , in Yellowstone National Park in the United States .	Old Faithful is a cone geyser in Wyoming , in Yellowstone National Park in the United States .
Old Faithful is not the tallest or largest geyser in the park ; that title belongs to the less predictable Steamboat Geyser .	Old Faithful is not the highest or biggest geyser in the park ; that title belongs to the less predictable Steamboat Geyser .
Over the years , the length of the interval has increased , which may be the result of earthquakes affecting subterranean water levels .	Over the years , the length of the difference of time has increased , which may be the result of earthquakes changing underground water levels .
In his 1871 Scribner 's account of the expedition , Nathaniel P. Langford wrote : In the early days of the park , Old Faithful was often used as a laundry : Eruptions can shoot 3,700 to 8,400 US gallons ( 14,000 to 32,000 L ) of boiling water to a height of 106 to 185 feet ( 32 to 56 m ) lasting from 1.5 to 5 minutes .	Eruptions can shoot 3,700 to 8,400 U.S. gallons ( 14-32 kL ) of boiling water to a height of 106-184 feet ( 30-55 m ) lasting from 1.5 to 5 minutes .
She is known for her role as Stella Malone in the Disney Channel sitcom television series Jonas L.A. .	She is best known for her role as Stella Malone in the Disney Channel sitcom Jonas L.A. .
She performed two of the songs on the film 's soundtrack .	She performs two of the songs on the film 's soundtrack .
She worked at Valley Youth Theatre .	She is an alumna of Valley Youth Theatre .
In 2007 , Kane starred in her first theatrical film role as Meredith Baxter Dimly , in the film Bratz : The Movie , playing the film 's antagonist .	In 2007 , she played her first starring role as well as her first theatrical role , in the theatrical motion picture Bratz : The Movie , as `` Meredith Baxter Dimly '' , the film 's primary antagonist .
In 2008 , she starred in the Disney Channel Original Movie , Minutemen , as Stephanie Jameson .	In 2008 , she acted in one of the Disney Channel Original Movies Minutemen as `` Stephanie Jameson '' , which aired on Disney Channel in January 2008 .
In Hyperion , the quality of Keats ' blank verse reached new heights , particularly in the opening scene between Thea and the fallen Saturn : Deep in the shady sadness of a vale , Far sunken from the healthy breath of morn , Far from the fiery noon , and eve 's one star , Sat gray-hair 'd Saturn , quiet as a stone , St...	Though neither version was ever finished , some critics think that they contain some of Keats 's best verse , as in the gloomy and powerful opening lines of the first Hyperion : Deep in the shady sadness of a vale Far sunken from the healthy breath of morn , Far from the fiery noon , and eve 's one star , Sat gray-hair...
`` Hyperion '' is an abandoned epic poem by 19th-century English Romantic poet John Keats .	Hyperion is one of the major poems of the English Romantic poet John Keats .
For these reasons hydraulic fracturing has come under international scrutiny , with some countries protecting it , and others suspending or banning it .	For these reasons hydraulic fracturing has come under scrutiny , with some countries suspending or banning it .
The first experimental use of hydraulic fracturing was in 1947 , and the first commercially successful applications were in 1949 .	The first use of hydraulic fracturing was in 1947 .
Opponents of hydraulic fracturing point to environmental risks , including contamination of ground water , depletion of fresh water , contamination of the air , noise pollution , the migration of gases and hydraulic fracturing chemicals to the surface , surface contamination from spills and flow-back , and the possible...	Opponents point to potential environmental effects , such as contamination of ground water , risks to air quality , the migration of gases and hydraulic fracturing chemicals to the surface , surface contamination from spills and flowback and the health effects of these .
Some hydraulic fractures form naturally-certain veins or dikes are examples .	Some hydraulic fractures form naturally : certain dykes are examples .
Proponents of hydraulic fracturing point to the economic benefits from the vast amounts of formerly inaccessible hydrocarbons the process can extract .	Proponents of hydraulic fracturing point to the economic benefits from the vast amounts of previously out of reach hydrocarbons .
Some of those countries , including most notably the United Kingdom , have recently lifted their bans , choosing to focus on regulation instead of outright prohibition .	However , some of those countries , including most notably the United Kingdom , have recently lifted their bans .
Hydraulic fracturing is the fracturing of rock by a pressurized liquid .	Fracking , or hydraulic fracturing , is forcing fractures in a rock layer , by pressurized fluid .
He remained with the department until his retirement in 1933 , and continued to work until his death in 1936 .	He stayed with the department until his retirement in 1933 , and continued to work until his death in 1936 .
He used both variants of his name until 1884 when he finally adopted Karl .	He used both versions of his name until 1884 when he finally adopted Karl .
He predicted that Galton , rather than Charles Darwin , would be remembered as the most prodigious grandson of Erasmus Darwin .	He predicted ( wrongly ) that Galton , rather than Charles Darwin , would be remembered as the most prodigious grandson of Erasmus Darwin .
A sesquicentenary conference was held in London on 23 March 2007 , to celebrate the 150th anniversary of his birth .	A conference was held in London on 23 March 2007 , to celebrate the 150th anniversary of his birth .
A major proponent of eugenics , Pearson was also a protégé and biographer of Sir Francis Galton .	He was a proponent of eugenics , and a protégé and biographer of Sir Francis Galton .
He formed the Department of Applied Statistics ( with financial support from the Drapers ' Company ) , into which he incorporated the Biometric and Galton laboratories .	He formed the Department of Applied Statistics , which included the Biometric and Galton laboratories .
Pearson was the first holder of this chair-the Galton Chair of Eugenics , later the Galton Chair of Genetics-in accordance with Galton 's wishes .	Pearson was the first holder of this chair , in accordance with Galton 's wishes .
Karl Pearson FRS ( \ / ˈpɪərsɨn \ / ) ( 27 March 1857 - 27 April 1936 ) ( originally named Carl ) was an influential English mathematician and biometrician .	Karl Pearson FRS ( 27 March 1857 - 27 April 1936 ) was an influential English mathematician .
When Galton died , he left the residue of his estate to the University of London for a Chair in Eugenics .	When Galton died , he left much of his estate to University College London for a Chair in Eugenics .
Eventually was universally known as `` KP '' .	Eventually he became known as `` KP '' .
The biography , done `` to satisfy myself and without regard to traditional standards , to the needs of publishers or to the tastes of the reading public '' , triumphed Galton 's life , work , and personal heredity .	The biography was done `` to satisfy myself and without regard to ... the needs of publishers or to the tastes of the reading public '' .
Pearson became Galton 's protégé - his `` statistical heir '' as some have put it - at times to the verge of hero worship .	Pearson became Galton 's protégé , at times close to hero worship .
Weldon introduced Pearson to Charles Darwin 's cousin Francis Galton , who was interested in aspects of evolution such as heredity and eugenics .	Pearson met Charles Darwin 's cousin Francis Galton , who was interested in heredity and eugenics .
He has been credited with establishing the discipline of mathematical statistics , and contributed significantly to the field of biometrics , meteorology , and theories of Social Darwinism and eugenics .	He helped establish the discipline of mathematical statistics .
Pearson 's thinking underpins many of the ` classical ' statistical methods which are in common use today .	Pearson 's ideas helped build the statistical methods in common use today .
`` Carl Pearson '' inadvertently became `` Karl '' when he enrolled at the University of Heidelberg in 1879 , which changed the spelling .	`` Carl Pearson '' became `` Karl Pearson '' by accident when he enrolled at the University of Heidelberg in 1879 .
Everton 's current shirt sponsors are Chang Beer .	Everton 's current shirt sponsor is a beer maker from Thailand , Chang Beer .
It was not until 1927 that Everton 's first sustained period of success began .	It was not until 1927 that Everton had their first period of long success .
Everton 's traditional away colors were white shirts with black shorts , but from 1968 amber shirts and royal blue shorts became common .	Everton usually wear royal blue shirts with white shorts and blue socks .
It was under David Moyes 's management that Wayne Rooney broke into the first team , before being sold to Manchester United for a club record fee of # 28 million .	Under his management Wayne Rooney was brought into the first team and he was quickly sold to Manchester United for # 27 million , a club record fee .
Everton 's second successful era started when Harry Catterick was made manager in 1961 .	This makes them the English football team with the most consecutive seasons in the top league of English football Everton 's second successful period came after 1961 when Harry Catterick was given the job of manager .
In 1925 the club signed Dixie Dean from Tranmere Rovers who , in 1927-28 , set the record for league goals in a single season with 60 goals in 39 league games , a record that still stands to this day .	In 1925 they signed Dixie Dean and in 1927 he scored 60 goals in 39 games , setting a new world record and taking Everton to another league title .
Royle dragged Everton clear of relegation , leading the club to the FA Cup for the fifth time in its history , defeating Manchester United 1-0 in the final .	In his second season in charge he kept Everton clear of relegation and won the FA cup , the club 's first trophy in seven years .
Everton were founded as St Domingo 's in 1878 so that people from the parish of St Domingo 's Methodist Church in Everton could play sport year round - cricket was played in summer .	Everton were founded in 1878 .
The club 's home colors are royal blue shirts and white shorts .	At first they wore white shorts and white shirts with blue stripes .
Everton Football Club \ / ˈɛvərtən \ / are an English Premier League football club based in Liverpool .	Everton Football Club or Everton F.C. are an English football club from the city of Liverpool .
Domestically , Everton won the FA Cup in 1984 and two league titles in 1984-85 and 1986-87 and the club 's first and so far only European trophy securing the European Cup Winners ' Cup in the 1985 final .	This era also brought Everton 's one and only European trophy win , the Cup Winners Cup in 1985 .
Draco is a genus of agamid lizards that also are known as flying dragons .	Draco is a genus of agamid lizards that are sometimes called the flying dragons .
The ribs and their connecting membrane may be extended to create a wing , the hindlimbs are flattened and wing-like in cross-section , and a small set of flaps on the neck serve as a horizontal stabilizers .	The hindlimbs are flattened and wing-like in cross-section , and a small set of flaps on the neck serve as a horizontal stabilizers .
The only time a flying lizard ventures to the ground is when a female is ready to lay her eggs .	The only time a flying lizard comes to the ground is when a female is ready to lay her eggs .
Glides as long as 60 m ( 200 ft ) have been recorded , over which the animal loses only 10 m ( 33 ft ) in height , which is quite some distance , considering that one of these lizards is only around 20 cm ( 7.9 in ) in total length ( tail included ) .	Glides as long as 60 m have been recorded , over which the animal loses only 10 m in height .
Tehran is the capital and largest city , serving as the cultural , commercial , and industrial center of the nation .	Tehran is the capital and its biggest city .
As a national academy , new members of the organization are elected annually by current members , based on their distinguished and continuing achievements in original research .	New members of the organization are elected annually by current members , based on their distinguished and continuing achievements in original research .
The National Academy of Sciences ( NAS ) is a non-profit organization in the United States .	National Academy of Sciences ( NAS ) is United States corporation whose members serve as advisers to the nation on science .
The ability to detect bitter-tasting , toxic compounds at low thresholds is considered to provide an important protective function .	The ability to detect bitter-tasting , toxic compounds at low thresholds may have a protective function , but some test have not confirmed this .
Bitterness is of interest to those who study evolution , as well as various health researchers since a large number of natural bitter compounds are known to be toxic .	Bitterness is of interest to those who study evolution , as well as various health researchers .
The division includes such towns as Armidale , Ashford , Barraba , Bingara , Bundarra , Glen Innes , Gunnedah , Guyra , Inverell , Manilla , Quirindi , Tamworth , Uralla , Werris Creek , Walcha and Tenterfield .	The includes the towns of Armidale , Ashford , Barraba , Bingara , Bundarra , Glen Innes , Gunnedah , Guyra , Inverell , Manilla , Quirindi , Tamworth , Uralla , Werris Creek , Walcha and Tenterfield .
The Division of New England is an Australian electoral division in the state of New South Wales .	The Division of New England is an Australian electoral division in New South Wales .
It is named after the New England region in northern New South Wales .	It is named after the New England region of northern New South Wales .
The current Member for New England , since the 2013 federal election , is Barnaby Joyce , a member of the National Party of Australia and a former Senator for the state of Queensland .	Barnaby Joyce is a former Senator for the state of Queensland .
The division is located in the north-east of the state , adjoining the border with Queensland .	It is in the north-east of the state , next to the border with Queensland .
He learns that the lamasery was constructed in its present form by a Catholic monk named Perrault from Luxembourg , in the early eighteenth century .	He learns that the lamasery was built by a Catholic monk named Perrault from Luxembourg in the early eighteenth century .
The doctor said Conway had been brought in by a Chinese woman who was ill and died soon after .	The doctor said Conway had been brought in by a Chinese woman who was ill .
The plane is hijacked and flown instead over the mountains to Tibet .	The plane is hijacked and flown over the mountains to Tibet .
The lamasery has modern conveniences , like central heating bathtubs from Akron , Ohio ; a large library ; a grand piano ; a harpsichord ; and food from the fertile valley below .	It has modern conveniences , like central heating ; bathtubs from Akron , Ohio ; a large library ; a grand piano ; a harpsichord ; and food from the valley below .
Once they have done so , their aging slows ; if they then leave the valley , they age quickly and die .	If they leave the valley , they age quickly and die .
The last time Rutherford saw Conway , it appeared he was preparing to make his way back to Shangri-La .	The last time Rutherford saw Conway , it seemed he was preparing to return to Shangri-La .
In a later audience , the High Lama reveals that he is finally dying , and that he wants Conway to lead the lamasery .	He wants Conway to lead the lamasery .
In the aeroplane of the Maharajah of Chandrapore are Conway , the British consul , age 37 Mallinson , his young vice-consul ; an American , Barnard ; and a British missionary , Miss Brinklow .	Conway , the British consul , age 37 ; Mallinson , his young vice-consul ; an American , Barnard ; and a British missionary , Miss Brinklow are in an airplane .
This ends Rutherford 's manuscript .	This ends Rutherford 's story .
Conway guesses correctly that the High Lama is Perrault , now 300 years old .	Conway guesses that the High Lama is Perrault , now 300 years old .
In May 1931 , during the British Raj in India , the 80 white residents of Baskul are being evacuated to ( Peshawar ) , owing to a revolution .	In May , 1931 , during the British Raj in India , 80 white residents were evacuated to Peshawar because of a revolution .
Meanwhile , Mallinson has arranged to leave the valley with porters and Lo-Tsen .	Meanwhile , Mallinson has arranged to leave the valley with Lo-Tsen and workers to carry their food and belongings .
Rutherford completes his account by telling the neurologist that he attempted to track Conway and verify some of his claims of Shangri-La .	Rutherford tells the neurologist that he tried to follow Conway and check his stories of Shangri-La .
The remote communities he visited , such as Muli , show many similarities to the fictional Shangri-La .	The remote communities he visited , such as Muli are similar to Hilton 's fictional Shangri-La .
Rutherford wrote down Conway 's story ; he gives the manuscript to the neurologist , and that manuscript becomes the heart of the novel .	Rutherford wrote down Conway 's story and gave it to the neurologist .

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