| Release Notes |
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| Release 108.0, 29th January 2026 |
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| New features include: |
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| * The addition of 1911 InterPro entries. |
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| * An update to NCBIFAM (18.0), Pfam (38.1). |
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| * Integration of 2891 new methods from the CATH-Gene3D (3), CDD (47), HAMAP (1), NCBIFAM (927), PANTHER (29), Pfam (1878), SMART (2), SUPERFAMILY (4) databases. |
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| Contents and coverage of InterPro 108.0 |
| InterPro protein matches are now calculated for all UniProtKB and UniParc |
| proteins. The following statistics are for all UniProtKB proteins. |
| InterPro release 108.0 contains 51489 entries, representing: |
| Active site 133 |
| Binding site 82 |
| Conserved site 768 |
| Domain 19276 |
| Family 27308 |
| Homologous superfamily 3510 |
| Ptm 17 |
| Repeat 395 |
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| Last Entry IPR061508 |
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| InterPro cites 63250 publications in PubMed. |
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| Member database information |
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| Signature Database Version Signatures* Integrated Signatures** |
| CATH-Gene3D 4.3.0 6631 2820 |
| CDD 3.21 19902 5040 |
| HAMAP 2025_01 2391 2386 |
| NCBIFAM 18.0 33732 7069 |
| PANTHER 19.0 15683 10491 |
| PIRSF 3.10 3285 3223 |
| PRINTS 42.0 2106 1938 |
| PROSITE patterns 2025_01 1311 1282 |
| PROSITE profiles 2025_01 1399 1303 |
| Pfam 38.1 27481 26620 |
| SFLD 4 303 160 |
| SMART 9.0 1322 1276 |
| SUPERFAMILY 1.75 2019 1649 |
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| * Some signatures may not have matches to UniProtKB proteins. |
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| ** Not all signatures of a member database may be integrated at the time |
| of an InterPro release. |
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| We use MobiDB-lite, a derivative of the MobiDB database, to provide consensus annotation of long-range intrinsic disorder in protein sequences. |
| Read more about MobiDB-lite in Bioinformatics, 33(9), 2017, 1402–1404, (doi: 10.1093/bioinformatics/btx015). |
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| Sequence Database Version Count Count of proteins matching |
| any signature integrated signatures |
| UniProtKB 2026_01 203130941 170583479 (84.0%) 166550181 (82.0%) |
| UniProtKB/TrEMBL 2026_01 202556314 170024218 (83.9%) 165992422 (81.9%) |
| UniProtKB/Swiss-Prot 2026_01 574627 559261 (97.3%) 557759 (97.1%) |
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| Total number of proteins included in InterPro |
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| Canonical sequences: 203130941 |
| Splice variants: 67353 |
| Total proteins: 203198294 |
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| InterPro to GO |
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| * Number of GO terms mapped to InterPro - 30200 |
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| Feedback |
| We need your help and would welcome any feedback. If you find errors or |
| omissions please let us know. You can contact us at: |
| https://www.ebi.ac.uk/support/interpro-general-query |
| Copyright |
| InterPro - Integrated Resource Of Protein Domains And Functional Sites. |
| Copyright (C) 2026 The InterPro Consortium. This manual and the |
| accompanying database may be copied and redistributed freely, without |
| advance permission, provided that this Copyright statement is reproduced |
| with each copy. |
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