Release Notes

======================================

Release 108.0, 29th January 2026

New features include:

* The addition of 1911 InterPro entries.

* An update to NCBIFAM (18.0), Pfam (38.1).

* Integration of 2891 new methods from the CATH-Gene3D (3), CDD (47), HAMAP (1), NCBIFAM (927), PANTHER (29), Pfam (1878), SMART (2), SUPERFAMILY (4) databases.

Contents and coverage of InterPro 108.0
InterPro protein matches are now calculated for all UniProtKB and UniParc
proteins. The following statistics are for all UniProtKB proteins.
InterPro release 108.0 contains 51489 entries, representing:
           Active site    133
          Binding site     82
        Conserved site    768
                Domain  19276
                Family  27308
Homologous superfamily   3510
                   Ptm     17
                Repeat    395



Last Entry IPR061508

InterPro cites 63250 publications in PubMed.

Member database information

Signature Database     Version              Signatures*          Integrated Signatures**
       CATH-Gene3D       4.3.0                     6631                             2820
               CDD        3.21                    19902                             5040
             HAMAP     2025_01                     2391                             2386
           NCBIFAM        18.0                    33732                             7069
           PANTHER        19.0                    15683                            10491
             PIRSF        3.10                     3285                             3223
            PRINTS        42.0                     2106                             1938
  PROSITE patterns     2025_01                     1311                             1282
  PROSITE profiles     2025_01                     1399                             1303
              Pfam        38.1                    27481                            26620
              SFLD           4                      303                              160
             SMART         9.0                     1322                             1276
       SUPERFAMILY        1.75                     2019                             1649



* Some signatures may not have matches to UniProtKB proteins.

** Not all signatures of a member database may be integrated at the time
of an InterPro release.

We use MobiDB-lite, a derivative of the MobiDB database, to provide consensus annotation of long-range intrinsic disorder in protein sequences.
Read more about MobiDB-lite in Bioinformatics, 33(9), 2017, 1402–1404, (doi: 10.1093/bioinformatics/btx015).


   Sequence Database     Version                Count                        Count of proteins matching        
                                                                       any signature      integrated signatures
           UniProtKB     2026_01            203130941                170583479 (84.0%)      166550181 (82.0%)
    UniProtKB/TrEMBL     2026_01            202556314                170024218 (83.9%)      165992422 (81.9%)
UniProtKB/Swiss-Prot     2026_01               574627                   559261 (97.3%)         557759 (97.1%)


Total number of proteins included in InterPro

Canonical sequences: 203130941
Splice variants: 67353
Total proteins: 203198294

InterPro to GO

*         Number of GO terms mapped to InterPro  - 30200


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Copyright
InterPro - Integrated Resource Of Protein Domains And Functional Sites.
Copyright (C) 2026 The InterPro Consortium. This manual and the
accompanying database may be copied and redistributed freely, without
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