Datasets:
File size: 3,861 Bytes
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Release 108.0, 29th January 2026
New features include:
* The addition of 1911 InterPro entries.
* An update to NCBIFAM (18.0), Pfam (38.1).
* Integration of 2891 new methods from the CATH-Gene3D (3), CDD (47), HAMAP (1), NCBIFAM (927), PANTHER (29), Pfam (1878), SMART (2), SUPERFAMILY (4) databases.
Contents and coverage of InterPro 108.0
InterPro protein matches are now calculated for all UniProtKB and UniParc
proteins. The following statistics are for all UniProtKB proteins.
InterPro release 108.0 contains 51489 entries, representing:
Active site 133
Binding site 82
Conserved site 768
Domain 19276
Family 27308
Homologous superfamily 3510
Ptm 17
Repeat 395
Last Entry IPR061508
InterPro cites 63250 publications in PubMed.
Member database information
Signature Database Version Signatures* Integrated Signatures**
CATH-Gene3D 4.3.0 6631 2820
CDD 3.21 19902 5040
HAMAP 2025_01 2391 2386
NCBIFAM 18.0 33732 7069
PANTHER 19.0 15683 10491
PIRSF 3.10 3285 3223
PRINTS 42.0 2106 1938
PROSITE patterns 2025_01 1311 1282
PROSITE profiles 2025_01 1399 1303
Pfam 38.1 27481 26620
SFLD 4 303 160
SMART 9.0 1322 1276
SUPERFAMILY 1.75 2019 1649
* Some signatures may not have matches to UniProtKB proteins.
** Not all signatures of a member database may be integrated at the time
of an InterPro release.
We use MobiDB-lite, a derivative of the MobiDB database, to provide consensus annotation of long-range intrinsic disorder in protein sequences.
Read more about MobiDB-lite in Bioinformatics, 33(9), 2017, 1402–1404, (doi: 10.1093/bioinformatics/btx015).
Sequence Database Version Count Count of proteins matching
any signature integrated signatures
UniProtKB 2026_01 203130941 170583479 (84.0%) 166550181 (82.0%)
UniProtKB/TrEMBL 2026_01 202556314 170024218 (83.9%) 165992422 (81.9%)
UniProtKB/Swiss-Prot 2026_01 574627 559261 (97.3%) 557759 (97.1%)
Total number of proteins included in InterPro
Canonical sequences: 203130941
Splice variants: 67353
Total proteins: 203198294
InterPro to GO
* Number of GO terms mapped to InterPro - 30200
Feedback
We need your help and would welcome any feedback. If you find errors or
omissions please let us know. You can contact us at:
https://www.ebi.ac.uk/support/interpro-general-query
Copyright
InterPro - Integrated Resource Of Protein Domains And Functional Sites.
Copyright (C) 2026 The InterPro Consortium. This manual and the
accompanying database may be copied and redistributed freely, without
advance permission, provided that this Copyright statement is reproduced
with each copy.
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