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current_release/release_notes.txt

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+Release Notes
+
+======================================
+
+Release 108.0, 29th January 2026
+
+New features include:
+
+* The addition of 1911 InterPro entries.
+
+* An update to NCBIFAM (18.0), Pfam (38.1).
+
+* Integration of 2891 new methods from the CATH-Gene3D (3), CDD (47), HAMAP (1), NCBIFAM (927), PANTHER (29), Pfam (1878), SMART (2), SUPERFAMILY (4) databases.
+
+Contents and coverage of InterPro 108.0
+InterPro protein matches are now calculated for all UniProtKB and UniParc
+proteins. The following statistics are for all UniProtKB proteins.
+InterPro release 108.0 contains 51489 entries, representing:
+           Active site    133
+          Binding site     82
+        Conserved site    768
+                Domain  19276
+                Family  27308
+Homologous superfamily   3510
+                   Ptm     17
+                Repeat    395
+
+
+
+Last Entry IPR061508
+
+InterPro cites 63250 publications in PubMed.
+
+Member database information
+
+Signature Database     Version              Signatures*          Integrated Signatures**
+       CATH-Gene3D       4.3.0                     6631                             2820
+               CDD        3.21                    19902                             5040
+             HAMAP     2025_01                     2391                             2386
+           NCBIFAM        18.0                    33732                             7069
+           PANTHER        19.0                    15683                            10491
+             PIRSF        3.10                     3285                             3223
+            PRINTS        42.0                     2106                             1938
+  PROSITE patterns     2025_01                     1311                             1282
+  PROSITE profiles     2025_01                     1399                             1303
+              Pfam        38.1                    27481                            26620
+              SFLD           4                      303                              160
+             SMART         9.0                     1322                             1276
+       SUPERFAMILY        1.75                     2019                             1649
+
+
+
+* Some signatures may not have matches to UniProtKB proteins.
+
+** Not all signatures of a member database may be integrated at the time
+of an InterPro release.
+
+We use MobiDB-lite, a derivative of the MobiDB database, to provide consensus annotation of long-range intrinsic disorder in protein sequences.
+Read more about MobiDB-lite in Bioinformatics, 33(9), 2017, 1402–1404, (doi: 10.1093/bioinformatics/btx015).
+
+
+   Sequence Database     Version                Count                        Count of proteins matching        
+                                                                       any signature      integrated signatures
+           UniProtKB     2026_01            203130941                170583479 (84.0%)      166550181 (82.0%)
+    UniProtKB/TrEMBL     2026_01            202556314                170024218 (83.9%)      165992422 (81.9%)
+UniProtKB/Swiss-Prot     2026_01               574627                   559261 (97.3%)         557759 (97.1%)
+
+
+Total number of proteins included in InterPro
+
+Canonical sequences: 203130941
+Splice variants: 67353
+Total proteins: 203198294
+
+InterPro to GO
+
+*         Number of GO terms mapped to InterPro  - 30200
+
+
+Feedback
+We need your help and would welcome any feedback. If you find errors or
+omissions please let us know. You can contact us at:
+https://www.ebi.ac.uk/support/interpro-general-query
+Copyright
+InterPro - Integrated Resource Of Protein Domains And Functional Sites.
+Copyright (C) 2026 The InterPro Consortium. This manual and the
+accompanying database may be copied and redistributed freely, without
+advance permission, provided that this Copyright statement is reproduced
+with each copy.

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