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Design and Setting |
Single-center cross-sectional study of 55 healthy women between 45 and 60 years of age. We measured lipid deposition in the liver with magnetic resonance spectroscopy, intramuscular and intra-abdominal lipid deposition with MRI, body composition with a dual-energy X-ray absorptiometry scan, and insulin sensitivity with... |
Outcome Measures |
We studied the association between fat distribution, ectopic lipid deposition, and insulin sensitivity in pre- and postmenopausal women. |
Results |
Postmenopausal women had an increased lipid deposition in the liver [0.68% (0.44 to 0.99) vs 0.49% (0.38 to 0.64), P = 0.01] and skeletal muscle [3% (2 to 4) vs 2% (1 to 3), P = 0.001] and had a 28% lower Matsuda insulin sensitivity index during an oral glucose tolerance test (6.31 ± 3.48 vs 8.78 ± 4.67, P = 0.05) comp... |
Conclusions |
For a given subcutaneous and visceral fat depot size, postmenopausal women show increased ectopic lipid deposition and insulin resistance compared with premenopausal women. It is suggested that lipid deposition in liver and skeletal muscle may represent important mechanistic links between the changes in fat depots and ... |
Tensile strained single-crystal GeSn on insulator (GSOI) was obtained using self-organized seeding lateral growth. Segregation of Sn atoms and Sn distribution occurred during the lateral growth of the GeSn stripe. At both edges of the GSOI, Sn concentration distribution was found in good agreement with calculation base... |
To enable effective use of phoA gene fusions in Legionella pneumophila, we constructed MudphoA, a derivative of the mini‐Mu phage Mu dII4041, which is capable of generating gene fusions to the Escherichia coli alkaline phosphatase gene (EC 3.1.3.1). Although an existing fusion‐generating transposon, TnphoA, has been a ... |
The formation of high-density, nanometer-scale dot (nanodot) arrays is a challenging task. Such arrays are considered important not only for scientific study of the fundamental quantum-mechanical behavior of materials, but also for achieving a practical goal of ultrahigh-density data storage and manipulation devices. [... |
The current stage of development of forensics is described by an active search for the latest cognitive methods and tools, which fully include forensic diagnostics. The relevance of the subject matter is conditioned by the need to form a modern terminology of the forensic science, further development of the scientific ... |
Injury of the superior mesenteric vein from blunt abdominal trauma is an uncommon but frequently fatal injury. A 63-year-old man was injured in a motorcycle accident. He was admitted to our hospital in profound shock. Immediate celiotomy revealed superior mesenteric vein injury which was repaired by end-to-end anastomo... |
The studies on alternative disinfection applications have been performed to protect public health from waterborne disasters, have recently accelerated to attain more effective inactivation of resistant microorganisms present in water. Usage of ultrasound (US) and silver ion (Ag+) are foremost applications among newly d... |
Background: Melanoma incidence is growing worldwide. Although recent advances in imaging, there isn`t still available a specific melanoma agent that can be used for melanoma staging. Archaeosomes may be defined as liposomes composed of one or more polar lipids extracted from the Archaea domain (Archaebacterium). Object... |
This communication is in essence a note tying together the structure theory of Bourbaki and the categorical structure theory exemplified in the works of Sonner, and Hedrlin, Pultr, and Trnkova, to name a few. The work of Bourbaki [1] appeared in 1957, and quietly succumbed to the explosion of category theory. Sonner [6... |
The self-interest of sports managers and players concerned with survival of their events, and of the media concerned with protecting advertising revenue, has resulted in little discussion on the appropriateness of tobacco and alcohol companies sponsoring sport. Three central factors in the controversy over permitting t... |
This paper proposes an IP finely-distributed loadbalanced routing scheme based on two-phase routing over shortest paths, where the traffic matrix is given. It is called the fine two-phase routing (F-TPR) scheme. In F-TPR, traffic is distributed from a source node to intermediate nodes more finely, compared to the origi... |
Studies in both humans and rodents have found that insulin+ cells appear within or near ducts of the adult pancreas, particularly following damage or disease, suggesting that these insulin+ cells arise de novo from ductal epithelium. We have found that insulin+ cells are continuous with duct cells in the epithelium tha... |
Polyribocytidylic-polyriboinosinic acid [poly r(I):r(C)]-inducible genes were isolated by a differential screening procedure from a human fibroblast cell (FS-4) cDNA bank. Among yet unidentified genes (gene 274), one codes for a protein with multiple finger motifs and has previously been detected in endothelial cells a... |
In early 2017 until February 2018, the Commission of Corruption Eradication arrested ten Regional Heads who redhandedly fired for political dowry and corruption. This research was sociological-juridical method with the aims of research to find the relation between political worry and corruption by regional heads. This ... |
Summary Starting in week 5 of lactation, goats were milked unilaterally once daily for 4 ½ weeks, then twice daily for 12 weeks and finally thrice daily for 2 weeks. The control gland was milked twice daily throughout. During less frequent milking, yield fell by 26%. There was a rapid and essentially complete recovery ... |
Inappropriate antimicrobial use is a key problem causing antimicrobial resistance and increased health care costs. Although global point prevalence surveys on antimicrobial prescribing in hospitals were described, there is lack of data from Turkish hospitals. Here, we aimed to perform systematic review and meta-analysi... |
This paper proposes and investigates a new equilibrium equivalence concept, which is more general than the conventional topological equivalence concept but offers easier analysis and better engineering insights for nonlinear system design. We prove an equilibrium equivalence theorem which guarantees the robustness of t... |
Discovering the underlying structures present in large real world graphs is a fundamental scientific problem. In this paper we show that a graph's clique tree can be used to extract a hyperedge replacement grammar. If we store an ordering from the extraction process, the extracted graph grammar is guaranteed to generat... |
Abstract Objectives. Evaluate the effects of a 6-month High Intensity Interval Training (HIIT) program on (1) functional capacity and health-related quality of life, (2) multiple blood biomarkers, (3) echocardiographic parameters, and (4) exercise performance, in patients in cardiac resynchronization therapy (CRT) stra... |
Over the past years, rapid growth due to urbanization and industrialization, the changes in Land over and land use patterns have resulted in permanent environmental pollution to the hydrological processes. The hydrological cycle in cities is seriously affected due to increasing impervious areas as a result of urban dev... |
NO deficiency is associated with development of hypertension. Defects in the renal citrulline-arginine pathway or arginine reabsorption potentially reduce renal NO in prehypertensive spontaneously hypertensive rats (SHRs). Hence, we investigated genes related to the citrulline-arginine pathway or arginine reabsorption,... |
Abstract Mangan, S, Malone, S, Ryan, M, Mc Gahan, J, Warne, J, Martin, D, O'Neill, C, Burns, C, and Collins, K. Influence of team rating on running performance in elite Gaelic football. J Strength Cond Res 32(9): 2584–2591, 2017—It is currently unknown how team rating influences running performance in Gaelic football. ... |
This paper describes a compact, imaging Twyman-Green interferometer to measure small features such as corrosion pits, scratches and digs on hard to access objects such as assembled parts. The shoebox size interferometer was designed to guarantee proper orientation and working distance relative to the inspected section.... |
Background: Leflunomide and its active metabolite A77 1726 reversibly inhibits the enzyme dihydro-orotate dehydrogenase, the rate limiting step in de novo synthesis of pyrimidines and progression of the cell cycle in different cell lines, mainly activated T lymphocytes. Objective: To analyse in vitro the possible anti-... |
Timely and effective wound treatment is of great significance in acute bleeding caused by accidents and chronic wounds such as diabetic foot ulcers, venous leg ulcers, pressure sores. A hydrogel as wound dressing can provide a suitable microenvironment for wound healing and prevent bacteria and dust from reaching the w... |
(1) Quantum theory deals not just with reality but with the physical (scientific) reality of its objects. Carl Friedrich von Weizsäcker understood this to imply that scientific knowledge of objects converges with philosophical knowledge of their objectivity but did not succeed in rounding off physics. (2) We are actors... |
Background Etiological theory and prior research with small or selected samples suggest that interpersonal violence clusters in families. However, the strength and pattern of this aggregation remains mostly unknown. Method We investigated all convictions for violent crime in Sweden 1973–2004 among more than 12.5 millio... |
Authority, a fundamental part of the teaching–studying–learning process, is a problematic and poorly understood component of classroom life. It can be said, in practical terms, that pedagogical authority is constructed in classrooms, in teacher–student interaction and in the spirit of their physical presence, confidenc... |
ABSTRACT Aim: Mitotic arrest deficient 2 (MAD2) is an essential spindle assembly checkpoint (SAC) protein. It prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Its overexpression leads to short survival and chromosomal instability in lung cancer but its significance in br... |
To investigate the correlation between clinical typing of coronavirus disease-19 patients and risk factors (age, sex, underlying disease), hematocrit (packed-cell volume), mean erythrocyte volume, standard deviation of erythrocyte volume distribution width, variation coefficient of erythrocyte distribution width and ot... |
When stimulated through their antigen receptor, without costimulation, T cells enter a state of antigen-specific unresponsiveness, termed anergy. B7-mediated costimulation, signaling via CD28, is sufficient to prevent the induction ofanergy. Here we show that ligation o f T cell receptor (TCR) by alloantigen alone, whi... |
The objective of this study was to investigate the sustained release of a hydrophilic drug, montelukast (MK), from two biodegradable polymeric drug delivery systems, in situ implant (ISI) and in situ microparticles (ISM). N-Methyl pyrrolidone (NMP), dimethyl sulfoxide (DMSO), triacetin, and ethyl acetate were selected ... |
This contribution presents part of the results produced by the University of Naples Federico II in the project PRIN 2017 TECH-START. The research investigates how the challenges of the circular economy and climate mitigation, combined with digital technologies, require new organisations for contemporary dwelling, inclu... |
We present a novel OptoMEA platform that combines multisite electrical recording with local chemical stimulation. Applying UV light pulses through an array of optical fibres aligned to transparent indium-tin oxide electrodes of an MEA biochip leads to local compound uncaging (e.g. glutamate), thereby stimulating only t... |
Angiogenesis is the proliferation of endothelial and smooth muscle cells to form new blood vessels. Largely muted after adolescence, angiogenesis may be reignited by cancerous cells. Neoangiogenesis plays a primary role in tumor growth and metastases. Antiangiogenic therapy to limit and even reverse the growth of tumor... |
ABSTRACT Latency-associated peptide of transforming growth factor β (TGF-β) (LAP) was used to determine whether in vivo modulation of TGF-β bioactivity enhanced pulmonary immunity to Mycobacterium bovis BCG infection in C57BL/6 mice. LAP decreased BCG growth in the lung and enhanced antigen-specific T-cell proliferatio... |
Ileal conduit volvulus is a rare complication of urinary diversion. It has been suggested that various factors including prolonged length of the ileal segment, lack of fixation of the conduit to the peritoneum and failure to close the incised mesentery predispose patients to this complication. We present the case of a ... |
In this paper we present a method for finding the optimal camera alignment for a tracking system with multiple cameras, by specifying the volume that should be tracked and an initial camera setup. The approach we use is twofold: on the one hand, we use a rather simple gradient based steepest descent method and on the o... |
A truly inclusive organization cultivates a sense of belonging and value in its members, realizing their contributions are vital to its success. Acknowledging and then dismantling exclusionary systems and policies are essential to creating environments grounded in diversity and equity. This process requires intentional... |
Current knowledge of percutaneous absorption of arsenic is based on studies of rhesus monkeys using soluble arsenic in aqueous solution, and soluble arsenic mixed with soil (Wester et al., 1993). These studies produced mean dermal absorption rates in the range of 2.0-6.4% of the applied dose. Subsequently, questions ar... |
Decisions to control pharmaceutical costs can cause conflicts as to what medications are covered. Such conflicts have ethical implications, however implicit, and given this fact, an ethical framework can help address them. In the following commentary, we discuss the more traditional, individual-level ethical considerat... |
The authors examined questions about diffusion of responsibility in groups by asking group members to apportion responsibility for an outcome to each group member: Does responsibility diffuse more as groups increase in size but eventually level off in larger groups? Does responsibility diffuse equally, with each member... |
This paper offers a discussion on a passage from the hypothesis of Cratinus’ Dionysalexandros (POxy 663 col. i, rr. 20-25). According to this source, Cratinus hinted, in his play, at Spartans’ invasions of Attic countryside during the first years of the Peloponnesian War. This is one of Aristophanes’ most typical comic... |
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