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pituitary abnormalities is procrastinated, which could have been otherwise beneted from early interventions. This case is a |
classic example of delayed exhibition of posterior hypopituitarism post traumatic brain injury, which has signicantly |
compromised the quality of life of the patient in later stage due to the failure of timely screening. |
Case Presentation:This is a case of 24 year old female who sustained a traumatic brain injury 3 years ago allegedly due to |
domestic abuse. The patient presented to the urology department with the complaints of polyuria, polydipsia, secondary |
amenorrhea, sleep disturbance and weight gain for 6-7 months. The patient was not under regular follow-up for the traumatic |
injury. On further evaluation, all the anterior pituitary hormones were found to be normal. We further investigated the case with |
biochemical investigations and an MRI of brain (plain and contrast) which showed a thickened enhancing pituitary stalk with |
absence of posterior pituitary bright spot with a normal anterior pituitary gland – suggestive of Central Diabetes Insipidus. |
Upon initiation with Desmopressin, the patient showed signicant symptomatic improvement. |
Conclusion:One of the most common complications of traumatic brain injury is hypopituitarism. Early screening for |
hypopituitarism in such cases will help us intervene early and improve the quality of life of the patients.Stabilizing cell phone video using inertial measurement sensors |
We present a system that rectifies and stabilizes video sequences on mobile devices with rolling-shutter cameras. The system corrects for rolling-shutter distortions using measurements from accelerometer and gyroscope sensors, and a 3D rotational distortion model. In order to obtain a stabilized video, and at the same ... |
Testing every product of a software product line (SPL) is often not feasible due to the exponential number of products in the number of features. Thus, the order in which products are tested matters, because it can increase the early rate of fault detection. Several approaches have been proposed to prioritize products ... |
Background: Shift work, noise, and physical workload are very common occupational exposures and they tend to cluster in the same groups of workers. Objectives: To study the short and long term effects of these exposures on risk of coronary heart disease (CHD) and to estimate the joint effects of these factors. Methods:... |
The preventive effect of the development of the late allergic eosinophilic rhinitis (LAER), a T helper (Th)2 type immune response, in BALB/c mice by kurozu moromi powder (kmp) was examined. Mice were pre-treated with or without (control) kmp intragastrically for 30 days (50mg/kg/day) and then LAER was induced by ovalbu... |
We develop a sensitivity function for the design of electron guns, based on a form of reciprocity implicit in Hamilton's equations of motion. The sensitivity function allows for the determination of the effect of small, arbitrary changes in electrode potentials, electrode positions, and magnet locations on specific bea... |
In this paper, we investigated the interface band alignment of TiN/ZrO2 and TiN/ZrO2-Al2O3-ZrO2 (TiN/ZAZ) structures by analyzing the conduction band offset (CBO) and valence band offset at the electrode/dielectric interface using depth-resolved spectroscopy techniques. At the center of the interface, which is defined ... |
New benzoyl- and naphthoyl-substituted phosphines have been synthesized, which are stable to air and moisture. Testing these so-called phosphomide ligands in the presence of different ruthenium precursors, the hydrogenation of sodium bicarbonate (NaHCO(3)) to sodium formate (NaHCO(2)) proceeded with good catalyst turno... |
THE veterinary surgeon providing service to a farm has to realise that money spent on veterinary fees must be transferred out of other investments. In general, that transfer should not be made unless it can be shown that the veterinary programme will be more profitable than the investment alternatives. The veterinary s... |
The point we are trying to explain in this communication is that a hard class of management problems needs appropriate optimization methodologies to be solved and that by using such methodologies one can obtain substantial gains and advances in the management of production and/or service systems. Such methodologies bec... |
David Lewis's modal realism claims that nothing can exist in more than one world or time, and that statements about how something would have been are to be analysed in terms of its counterpart. I first explain why the counterpart relation depends on de re modal statements in an intensional language, so that intuitive p... |
Over the past year, the University of Rhode Island (URI) has taken some steps towards shifting the default to Open Access for both faculty scholarship and student work. First and foremost, in March 2013, the URI Faculty Senate passed a Harvard-style Open Access mandate. And in February 2013, the Library and the Graduat... |
We read with great interest the article entitled ‘Abuse-deterrent formulations: transitioning the pharmaceutical market to improve public health and safety’ by Simon and colleagues, published in the April 2015 Issue of Therapeutic Advances in Drug Safety [Simon et al. 2015]. We agree with the authors that Federal abuse... |
However, we disagree with the statement ‘ADFs have been proven to reduce prescription drug abuse and its consequences, and even an incremental reduction in abuse can have a significant impact on the nation by reducing the costly social, physical, mental, and public health problems resulting from abuse’. |
The study by Coplan and colleagues [Coplan et al. 2013] was quoted as the main reference to support the argument by Simon and colleagues that ‘ADF have been proven to reduce prescription drug abuse and its consequences…’. However, in the study by Coplan and colleagues, what was additionally reported was a 20% increase ... |
Michna and colleagues examined the degree of adherence to the ER opioid, following its switching to a reformulated ER opioid (ADF), and found some patients changed to other ER opioids without abuse-deterrent technology or discontinued ER opioids [Michna et al. 2014]. The conclusion of their study was that abusers may s... |
Preliminary data suggest that the reformulation of opioids to resist tampering may influence media attention, recreational user preferences, and opioid availability in ways that may in turn alter their attractiveness to recreational users [Romach et al. 2013]. ER oxymorphone abuse has been mentioned in popular media on... |
Indeed, total oxymorphone prescriptions increased sharply from 268,000 in 2007 to 1.22 million in 2012. In the first quarter of 2011, 325,000 oxymorphone prescriptions were dispensed by retail pharmacies [Drug Enforcement Administration, 2013]. According to the Drug Abuse Warning Network (DAWN ED), total estimated emer... |
Another issue of great concern is escalating heroin abuse since the introduction of reformulated ER oxycodone (ADF) to the market. There were 119,000 total users in 2003, but 281,000 by 2011. In addition, first-time past-year use nearly doubled between 2005 and 2011. The death rate of heroin overdose from the 28 states... |
In conclusion, at this point, the introduction of ADF opioids has resulted in significantly reduced abuse of those specific ADF opioids after they have fully replaced the original formulations. However, this has resulted in merely a shift away from the ADF opioids to other traditional non-ADF opioids or heroin, and unf... |
Objective: Development of effective drug delivery in the treatment of psoriasis is the major challenge for its successful management. To develop and assess the potential of Nanostructured Lipid Carriers (NLCs) enriched with the powdered leaves extracts of Azadirachta indica (AE), Lawsonia inermis (LE) and fruit extract... |
Methods: Drug loaded NLCs were prepared via hot homogenization technique by adopting 23 factorial design with factors X1 as the concentration of lipids, X2 concentration of surfactants and X3 being the number of homogenization cycle. The responses Y1 and Y2 were particle size and zeta potential. The optimized batch was... |
Results: The optimized batch of NLCs was found within the nanosized range with a relatively low polydispersity index and zeta potential of-20mV. The %EE for an optimized batch of NLCs was found to be 98.97±0.83%, 96.99±0.56% and 99.25±0.55% and the %DL of 21.84±0.15%, 8.55±045%, and 87.91±0.38% respectively for AE, LE ... |
The SEM images showed the spherical vesicular structures of drugs loaded NLCs. The in-vitro diffusion of drugs from the NLCs followed initial burst release thereafter sustained release for 24 h. The AE, LE and ME loaded NLCs proved to possess anti-lipid peroxidation and nitric oxide scavenging activities, cytotoxicity ... |
Conclusion: AE, LE and ME loaded NLCs can be used for prolonged topical delivery to the psoriatic skin for an effective treatment.Improving connectivity and power efficiency in wireless ad hoc networks through agent nodes |
In this paper, we present a framework that improves the reliability and reduce the power consumption of a wireless ad hoc network through the deployment of supplementary nodes called agents. Agents are stationary nodes that have less stringent power constraints than the battery-operated mobile nodes. Placed in a mesh-l... |
"Dr Martin replies below: Sir, I would agree with some of the statements made by Drs Cook and Lipsedge: for instance, my article describes improvement only in isolated areas and in some patients. I also agree that in other studies a lower mortality was achieved by a non-prescribing policy. However, when considering the... |
A fluorescent liquid-penetrant inspection of an experimental stator vane of a first-stage axial compressor revealed the presence of a longitudinal crack over 50 mm (2 in.) long at the edge of a resistance seam weld. The vane was made of titanium alloy Ti-6Al-4V (AMS 4911). The crack was opened by fracturing the vane. ... |
Different polyamide water separation films were prepared by interfacial polymerization by using different concentrations of Ethylenediamine (EDA)/H2O and some Trimesoylchloride (TMC)/Toluene on the modified Polyacronitrile (mPAN) substrates. By applying a slow positron beam, depth profiles of relative free volume hole ... |
Home range is an "area utilized by an individual during its normal activities such as food gathering, mating, and caring for young" (Burt 1943), as distinguished from its territory, which is typically defended against intrusion by other individuals of the same species, except a mate or a potential mate (Nice 1941). Hom... |
Exposure of hamster pancreatic islets to hyaluronidase during isolation by means of collagenase inhibits the insulinotropic action of several chemically different sulfonylureas, leucine, and glucagon without affecting glucose-stimulated insulin secretion. This inhibition is reversible for tolbutamide and leucine but ir... |
As an important device for line support and electrical insulation in power system, Insulators play a pivotal role in the high-voltage lines of the power grid. To overcome the shortcomings of insulator aerial photography at present, this paper proposes a deep learning model based on improved YOLOV5 to realize insulator ... |
The Fe(II)- and α-ketoglutarate (αKG)-dependent dioxygenases use mononuclear nonheme iron centers to effect hydroxylation of their substrates and decarboxylation of their cosubstrate, αKG, to CO2 and succinate. Our recent dissection of the mechanism of taurine:αKG dioxygenase (TauD), a member of this enzyme family, rev... |
Metabolically versatile pure cultures were isolated from textile dye effluent and petrochemical industry which were able to utilize 150 mg/l of 4-Chlorophenol and 85 mg/l of 4-Nitrophenol as the sole carbon and energy source respectively. Phylogenetic analysis based on 16 S rRNA gene sequence reveals that the strains w... |
Background |
Sensory impairments increase with age and the majority of older people will experience a sensory impairment if they live long enough. However, the relationships of hearing, visual, and olfactory impairments with mortality are not well understood. |
Methods |
Epidemiology of Hearing Loss Study participants (n = 2,418) aged 53-97 years (mean = 69 years) were examined in 1998-2000 and hearing, visual acuity, and olfaction were measured. Participants were followed for mortality for up to 17 years (mean = 12.8 years). Cox proportional hazards models were used to assess the asso... |
Results |
A total of 1,099 (45.4%) of participants died during the follow-up period. In age- and sex-adjusted Cox models, the risk of mortality was higher among participants with one (hazard ratio [HR] = 1.40, 95% confidence interval [CI] = 1.19, 1.64) or two or more (HR = 2.12, 95% CI = 1.74, 2.58) sensory impairments than amon... |
Conclusion |
Olfactory impairment, but not hearing or visual impairment, was associated with an increased risk of mortality. These results suggest that olfactory impairment may be a marker of underlying physiologic processes or pathology that is associated with aging and reduced survival in older adults.Tutor-facilitated Adult Digi... |
While the digital divide has decreased, those who are still unable to access and use information and communication technologies are left further behind. An effective digital literacy program helps underserved populations gain needed skills and alleviate the demand placed on public library staff. This case study present... |
Context |
Menopause is associated with an increased incidence of insulin resistance and diabetes. |
Objective |
The aim of this study was to explore the lipid deposition in liver and skeletal muscle and investigate the association with insulin sensitivity in postmenopausal and premenopausal women. |
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