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BACKGROUND/AIM |
Midkine (MK), a heparin-binding growth factor, has an important role in cancer progression. The aim of this study was to determine MK expression in breast tissue and the preoperative and postoperative serum levels of patients with breast cancer. |
MATERIALS AND METHODS |
Sixty-one patients with breast cancer participated in our study. The MK serum levels were measured pre- and postoperatively for these patients. We also analyzed breast tissues of the 61 patients immunohistochemically. We examined serum midkine levels in 49 healthy volunteers. |
RESULTS |
MK expression was observed in 44 (72.1%) of 61 breast cancer patients. In breast cancer patients the serum MK levels (3.68 ± 2.13 ng/mL (mean ± SD)) were significantly higher than in the control group (1.77 ± 0.38 ng/mL) before tumor removal (P = 0.000). After tumor removal, serum MK levels (2.47 ± 1.00 ng/mL) were sig... |
CONCLUSION |
We found that increased serum MK levels and protein expressions were associated with the carcinogenesis of breast cancer. MK levels decreased after tumor removal. According to our findings, MK might be a useful tumor marker for patients with breast cancer.The global distribution of PCBs and organochlorine pesticides in... |
In this study we explored the use of butter as a sampling matrix to reflect the regional and global scale distribution of PCBs and selected organochlorine pesticides/metabolites in air. This was because persistent organic pollutants (POPs) concentrate in dairy fats, where concentrations are controlled by feed intake (p... |
With the continuous development of science and technology, today's artificial intelligence technology has become quite mature. Artificial intelligence has many advantages. It can solve many problems in my country's computer technology and can fully reflect the role of computer network technology. Therefore, it is quite... |
A sequential and integrated metallographic procedure has been developed and successfully employed to differentiate between carbide, sigma, chi, Laves and ferrite phases which are commonly encountered in type 316 austenitic steel. The experimental techniques of optical and electron microscopy to identify these phases ha... |
The free volume in epoxy resins is strongly connected with the cross-linking process of resin and hardener. In-situ measurements of conventional positron annihilation lifetime spectroscopy (PALS) were carried out to investigate the free volume during post-curing of the epoxy resin system diglycidil ether of bisphenol A... |
Several protocols have recently been defined for smart grids that enable the communication between electric devices and energy management systems. While these protocols and architectures can already be applied in different fields of micro grids, it is still not clear how the distributed resources and constraints of suc... |
In colorization-based coding, a chrominance component is reconstructed by applying a colorization matrix to a vector which contains a few color information. The conventional method formulated the colorization-based coding problem into an optimization problem. Since this approach obtains the optimal color information wi... |
The appearances of the tracked object and its surrounding background usually change during tracking. As for tracking methods using subspace analysis, fixed subspace basis tends to cause tracking failure. In this paper, a novel tracking method is proposed by using incremental 2D-LDA learning and Bayes inference. Increme... |
The goal of this research was to compare the creative tension of university students in South Korea and Finland at three different universities. The creative tension, or the gap between a personal vision and the current reality, was analyzed according to relevant competences in a project manager's work role. In this ca... |
Extensive facial-orbital tumors are basal cell carcinomas which are exceptionally difficult to treat by conventional therapy because of: (1) skin involvement of more than one square inch of the eyelids of face; (2) fixation to bone or periosteum at the orbital rim; and (3) extension onto the inner surface of the eyelid... |
Although we still don't know the cause, there has been much research into the immune and pathological mechanisms that underlie oral lichen planus (OLP) and it is now possible to piece together a much clearer picture of the disease process. There is consensus that in OLP there is chronic, cell-mediated, immune damage to... |
We present a homogenization method based on two scale matched asymptotic expansion techniques for arrays of Helmholtz resonators. In the resulting effective model, the array is replaced by a homogeneous and anisotropic medium accounting for the cavities of the resonators while jump conditions apply across a fictitious ... |
Cannabinoids, the active components of Cannabis sativa Linnaeus (marijuana) and their derivatives have received renewed interest in recent years due to their diverse pharmacologic activities such as cell growth inhibition, anti-inflammatory effects and tumor regression. Here we show that expression levels of both canna... |
V F Weisskopf London: MIT Press 1972 pp xv + 368 price £3.60 This makes an attractive present for anyone who is fascinated by physics. Viki Weisskopf is a theoretical physicist, but not one of those whose main interest it is to solve difficult mathematical problems which physics is apt to generate.Density Functional Th... |
In this work, interactions between carboxylate ions and calcium or sodium ions are investigated via density functional theory (DFT). Despite the ubiquitous presence of these interactions in natural and industrial chemical processes, few DFT studies on these systems exist in the literature. Special focus has been placed... |
Abstract The concept of least squares (LS) as applied to an inconsistent system of linear or nonlinear equations is a fundamental tool in numerical analysis. Furthermore, these techniques have been applied with much success in solving many of the more challenging problems found in signal processing. In the standard LS ... |
A rapid fine energy tuning method for a double-crystal monochromator (DCM) is developed by combining a feedback control system with a phase sensitive detector. This method maintains both a parallel angle between the first and second crystals of the DCM and the peak of the rocking curve. The method is used to perform a ... |
The origins of the concept of replacement alternatives in the 1950s, and the impact of societal changes in the 1960s and 1970s, resulting in stricter controls on animal experimentation from the 1980s, based on the Three Rs of Russell and Burch (reduction, refinement and replacement), are reviewed. The range of replacem... |
1-beta-D-Arabinofuranosylcytosine-5'-stearylphosphate (cytarabine ocfosfate, stearyl-ara-CMP) is a newly synthesized 5'-alkylphosphate derivative of 1-beta-D-arabinofuranosylcytosine (ara-C), which is lipophilic, resistant to inactivation by deamination, and orally active. Pharmacology of this drug was studied in patie... |
BACKGROUND |
Stomach cancer, also known as gastric adenocarcinoma, remains the most common and deadly cancer worldwide. Its early diagnosis and prevention are effective to improve the 5-year survival rate of the patients. Therefore, it is important to discover specific biomarkers for early diagnosis and drug treatment. This study i... |
METHODS |
The gene expression profiles, GSE63089, GSE33335, and GSE79973, were retrieved for the identification of differentially expressed genes (DEGs) within a total of 80 gastric cancer samples and 80 normal samples. A total of 1423 up- and 1155 downregulated genes were screened for overlapping DEGs visualized via Venn diagra... |
RESULTS |
Finally, 5 machine learning methods were employed for the validation of two hub genes (COL1A1, LUM) to distinguish between the cancer samples and non-cancer samples. The accuracy of XGBoost was estimated to be 0.9375, and the precision and specificity as 1.000. The highest recalls of LR and MLP were 1.0000, and the AUC... |
CONCLUSION |
The identified hub genes explored in this study would enhance the understanding of the molecular mechanism of gastric cancer and may be regarded as a potential therapeutic target as assessed by integrating bioinformatics and machine learning methods.Neutrophil-to-lymphocyte ratio and microvascular complications in subj... |
Background/aim: The aim of this study is to find the association between diabetic microvascular complications and the neutrophil-to-lymphocyte ratio (NLR) in subjects with type 2 diabetes. Materials and methods: This was a retrospective study based on hospital data records from January 2005 to May 2016 at the Baqai Ins... |
In a layer of grains that interact through a tunable dipolar force, we show that an instability occurs due to the competition between gravity and the interaction between grains. Above a critical intensity of the interaction, the flat surface of the layer is unstable and peaks are generated. Fluctuations are shown to ha... |
This paper reports wafer-level backside process technology, established with the intent to ensure stable operation of InP ICs in the submillimeter wavelength band, which generally suffer from ground bounce and substrate resonance. Our process consists of thinning a 3-in InP wafer, forming dense vias with interval cooli... |
Abstract The subject of the study was four populations of signal crayfish from Naryjska Struga River and lakes Pobłędzie, Mauda, and Staw Płociczno. The morphometric differentiation of female and male signal crayfish was studied with discriminant analysis. It was confirmed that both females and males from the Naryjska ... |
The impact of the Industry Revolution 4.0 (IR4.0) in the workplace requires organisations to ensure clerical employees can effectively transfer their newly acquired knowledge and skills learned in training back into the workplace. Hence, an instrument is required to identify factors influencing the intention to transfe... |
Body-centric wireless networks are used for connectivity between on-body and on-off body communications for various applications for rescue, diagnostics and medical usage. Multiple features of modern portable and wearable devices necessitate antenna operation at a number of frequencies. A compact, low profile and multi... |
OBJECTIVE |
To assess the accuracy of automated readings of urine dipstick results for assessment of glucosuria in dogs and cats, compare visual versus automated readings of urine glucose concentration, and determine the utility of the urine glucose-to-creatinine ratio (UGCR) for quantification of glucosuria. |
SAMPLE |
310 canine and 279 feline urine samples. |
PROCEDURES |
Glucose concentration was estimated in 271 canine and 254 feline urine samples by visual assessment of urine dipstick results and with an automated dipstick reader. Absolute urine glucose and creatinine concentrations were measured in 39 canine and 25 feline urine samples by colorimetric assay with a clinical chemistry... |
RESULTS |
Automated assessment of the urine dipsticks yielded accurate results for 163 (60.1%) canine urine samples and 234 (92.1%) feline urine samples. Sensitivity of the automated dipstick reader for detection of glucosuria was 23% for canine samples and 68% for feline samples; specificity was 99% and 98%, respectively. Visua... |
CONCLUSIONS AND CLINICAL RELEVANCE |
Urine dipstick readings for dogs and cats were useful for ruling glucosuria in when the result was positive but not for ruling it out when the result was negative. The evaluated dipsticks were more accurate for detection of glucosuria in cats than in dogs. Visual dipstick readings were more accurate than automated read... |
OBJECTIVE |
To examine changes to hospital admission rates, length of stay (LOS), bed use, and unplanned readmission rates for children with acute exacerbations of asthma following the change of the Victorian health care system to casemix funding. |
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