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Clinical trials would gain from incorporating 'Phase 0' chronobiologic pilot designs both from the viewpoint of (statistical) power and cost-effectiveness. Herein, this statement is documented by power computations and is further illustrated by clinical examples answering specific questions. Power computations show the... |
This paper addresses the synergy and antagonism between symptoms and signs among 2,914 elderly Canadians diagnosed in 15 categories, including no cognitive impairment, cognitive impairment but no dementia, mild, moderate and severe forms of Alzheimer's disease and vascular dementia, 4 subtypes of possible Alzheimer's d... |
Based on the radial basis function neural network (RBFNN) theory and the specialty of hyperspectral remote sensing data, the effective feature extraction model was designed, and those extracted features were connected to the input layer of RBFNN, finally the classifier based on radial basis function neural network was ... |
BACKGROUND |
The chemokine receptor CCR5 acts as a co-receptor for HIV binding and it is considered as an important target by CCR5 antagonists. Entry inhibitor based microbicides gain much importance nowadays as these drugs act at an early stage of HIV lifecycle and thus hinder the viral replication process in humans. The present s... |
METHODS |
The pharmacophore modeling and 3D QSAR studies was used to screen CCR5 antagonists with enhanced antagonist activity. The docking studies ranked the compounds according to their binding affinity and molecular dynamics simulation validated the stability of the enzymeligand complex. |
RESULTS |
A five point pharmacophore hypothesis HHPRR (2 hydrophobic; 1 positively ionisable; 2 aromatic ring) was generated. A statistically significant 3D QSAR model with 3 PLS factors was gen- erated for common pharmacophore hypothesis HHPRR.3 with good correlation coefficient value (R2=0.7483). The docking studies revealed t... |
CONCLUSION |
The present study was successful in identifying a CCR5 antagonist which could be developed as a microbicide.Probing Dark Current Random Telegraph Signal in a Small Pitch Vertically Pinned Photodiode CMOS Image Sensor After Proton Irradiation |
The dark current degradation and dark current random telegraph signal (DC-RTS) after proton irradiation are studied in new scale silicon microvolumes by using a commercial CMOS image sensor. Results show that previously reported empirical models describing the displacement damage-induced degradations are still valid de... |
BACKGROUND |
Age-related mechanisms of sarcopenia associated with vascular function have been recently suggested. This study compared and tested associations between muscle mass and strength, microcirculation, inflammatory biomarkers, and oxidative stress in older adults classified as sarcopenic and non-sarcopenic. |
METHODS |
Thirty-three physically inactive individuals (72±7 yrs) were assigned to age-matched sarcopenic (SG) and non-sarcopenic (NSG) groups. Between-group comparisons were performed for appendicular skeletal mass (ASM), handgrip and isokinetic strength, microvascular function and morphology, C-reactive protein, insulin-like g... |
RESULTS |
ASM and knee isokinetic strength were lower in SG than NSG (P < 0.05). No difference between groups was found for outcomes of microvascular function and morphology, but log-transformed IL-6 concentration was twice greater in SG vs. NSG (P = 0.02). Correlations between ASM index, handgrip and knee isokinetic strength v... |
CONCLUSION |
Decreased ASM index and strength have been associated with microcirculatory profile, indicating that microcirculation impairment may be involved somehow in Sarcopenia development. The inflammation status, particularly elevated IL-6, seems to play an important role in this process.Impact of Medicaid Expansion on the Dia... |
BACKGROUND |
Insurance status has been associated with disparities in stage at cancer diagnosis. We examined how Medicaid expansion (ME) impacted diagnoses, surgical treatment, use of neoadjuvant therapies (NCRT), and outcomes for Stage II and III rectal cancer. |
STUDY DESIGN |
We used 2010-2017 American College of Surgeons National Cancer Database (NCDB) to identify patients ages 18-65, with Medicaid as primary form of payment, and were diagnosed with Stage II or III rectal cancer. Patients were stratified based on Census bureau division's ME adoption rates of High, Medium, Low. Overall tren... |
RESULTS |
Over 8 years of NCDB data examined, there was an increasing trend of Stage II and III rectal cancer diagnoses, surgical resection, and use of NCRT for Medicaid patients. We observed an increase in age, proportion of White Medicaid patients in Low ME divisions, and proportion of fourth income quartile patients in High M... |
CONCLUSIONS |
Medicaid expansion had important impacts on increasing Stage II and III rectal cancer diagnoses, use of NCRT, and decreased 90-day mortality for patients with Medicaid. Our study supports increasing health insurance coverage to improve Medicaid patient outcomes in rectal cancer care.Applying Wireless Sensor Networks to... |
Context aware ubiquitous learning is pervasive and persistent, allowing learners to access education calmly, flexibly and seamlessly. The objective of context aware ubiquitous learning is to move e- learning and mobile learning a step further from learning at anytime anywhere to be at the right time and right place wit... |
The 1990’s have witnessed a resurrection of an interest in the origins of language (in fact, such an interest had never actually faded). Although pin-pointing the exact triggers behind the initial sparkles is difficult, one may advocate for the integration of a number of scientific advances, including the first compute... |
The tear film covers the cornea, and its abnormalities (including immunological) induce dry eye. Using autoimmune disease model mice, BXSB/MpJ-Yaa (BXSB-Yaa), histopathological changes in the eye and tear-secreting tissues were examined using histopathology, immunohistochemistry, and electron microscopy at 8, 20, and 2... |
Fforde, Jasper. The Last Dragonslayer. Toronto: HarperCollins, 2011. Print. Almost-16-year-old Jennifer Strange is caught in a unique situation. As an orphan and an indentured servant of Kazam Mystical Arts, an employment agency for the magically gifted, Jennifer suddenly finds herself running the agency due to the mys... |
OBJECTIVE |
To test the feasibility of in situ DNA quantitation of adherent cells' nuclei by fluorescence imaging, preserving chromatin structure and to follow-up S phase, in relation to DNA content, in order to assess the precision of DNA measurements. |
STUDY DESIGN |
Double labeling experiments involved total DNA staining with Hoechst 33342 and BrdU immunostaining (after either Br photolysis and DNA strand break labeling by terminal transferase or acid denaturation) to detect replicating DNA. An epifluorescence microscope was used, images captured with a CCD camera and quantitative... |
RESULTS |
In cells progressing through the cycle, as assessed by BrdU, a corresponding increase in DNA content was measured. Early S differed from G1 (P < .05). Imastat analyses gave a CV for GI peak of 6-7%. |
CONCLUSION |
Quantitative fluorescence imaging allows a sensitive determination of DNA content for adherent-cell nuclei in situ. Topologic analyses of nuclear components will be possible in relation to DNA content.DNA gyrase gyrA mutations in quinolone-resistant clinical isolates of Staphylococcus haemolyticus |
Staphylococci are significant human pathogens. Coagulasepositive Staphylococcus aureus causes a variety of infections. Recently, coagulase-negative staphylococci have been recognized as important pathogens. Fluoroquinolones have been widely used to treat staphylococcal infections. However, quinolone-resistant strains h... |
New developments in deep brain stimulation (DBS) enable both openand closed-loop modulation of brain structures and functions that are important to the clinical treatment of a number of neuropsychiatric disorders and conditions. Ongoing clinical trials and investigator-initiated research (IIR) in DBS have generated res... |
ABSTRACT Human astroviruses (HAstVs) are a common etiological agent of infantile gastroenteritis. Recent studies revealed that novel astrovirus (AstV) strains of the MLB clade (MLB-AstVs) and VA clade (VA-AstVs), which are genetically distinct from the classic HAstVs, are circulating in the human population. In the pre... |
The highly lipophilic outer barrier of mycobacteria, such as M. tuberculosis and M. leprae, is key to their virulence and intrinsic antibiotic resistance. Various components of this mycomembrane interact with the host immune system but many of these interactions remain ill‐understood. This review covers several chemica... |
Fractionation of the biomass of 3 serogroup B N. meningitidis strains, obtained from solid serum-free and liquid synthetic media, by increasing concentrations of cetavlone revealed that the formation of natural polysaccharide-protein complexes with the ratio of their components approaching 1:1 was possible under the co... |
Picasecond temporal response and broad spectral response photodetectors have been fabricated using commercially available diode chips. Improved photoresponse sensitivity is achieved by removing the anode gold contact which obscures the active region. Junction geometry is such that the depletion region is approximately ... |
Five studies examined the relations between attitude importance and 3 of its hypothesized determinants: self-interest, social identification with reference groups or reference individuals, and cherished values. Verbal protocols, multivariate analysis of survey data, and laboratory experimentation revealed that (1) peop... |
With the development of prefabricated buildings, the construction mode of buildings has changed greatly. Infilled wall is an important part of architecture. The traditional manual masonry method is not suitable for the construction of prefabricated buildings. Precast concrete infilled wall, as a form of infilled wall s... |
In this paper, a rotor-flux-oriented control scheme for seven-phase induction motor drives is presented. At low speed the proposed control scheme is able to increase the motor torque by adding a third harmonic component to the air-gap magnetic field. Above the base speed the control system reduces the motor flux in suc... |
This study aimed to compare the efficiency of the thermal blanket and thermal mattress in the prevention of hypothermia during surgery. Thirty-eight randomized patients were divided into two groups (G1 - thermal blanket and G2 - thermal mattress). The variables studied were: length of surgery, length of stay in the pos... |
THE SCOPE OF DRUG discovery and development has expanded and accelerated in recent years. Research efforts in drug discovery have broadened to include start-up biotechnology companies, research institutes within major domestic and international pharmaceutical companies, and useful collaborations between industry and ac... |
Nonvolatile resistive switching memristance devices with a high on/off ratio are desirable for nanoelectronics such as resistive random‐access memory (RRAM) and in‐memory computing. Here, bipolar resistive switching in point‐contacted W/LaAlO3/SrTiO3(111) heterojunctions is reported, in which a Schottky barrier is form... |
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