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The hydropathy plot of the inwardly rectifying ROMK1 K+ channel, which reveals two transmembrane and a pore region domains, also reveals areas of intermediate hydrophobicity in the N terminus (M0) and in the C terminus (post‐M2). Peptides that correspond to M0, post‐M2, and a control peptide, pre‐M0, were synthesized a... |
Background. Complex surgical resection and reconstruction for rare thoracic cancers (RTCs) represent a major challenge, given their very low frequency, extreme variability of presentation, multi-modality treatment options and inadequate outcome prediction. We reported the experience of a tertiary referral centre on a c... |
People working as cleaners represent a substantial part of the modern British working class. Low-paid, often part-time, disproportionately female and, more recently, from black and minority ethnic and migrant communities, this workforce has historically been seen as hard to organise. Yet the Covid-19 crisis has elevate... |
Approximately 30% of ovarian and breast cancers overexpress p185(c-erbB-2) with as many as 10(6) receptors/cell. Normal cells have as few as 10(4) receptors/cell. We have examined the susceptibility of SKOv3 human ovarian cancer cells to anti-c-erbB2 antibodies and immunotoxins as a function of c-erbB-2 density on the ... |
This case is of a 52-year-old lady, who presented with a 7-day history of headache associated with nausea and vomiting. On physical examination, she was apyrexial, and neurological examination was unremarkable. She had a history of seropositive rheumatoid arthritis diagnosed 20 years previously. During this time, she h... |
Laboratory investigations on admission showed haemoglobin of 135 g/l, white cell count of 9.7 × 109/l, platelets of 171 × 109/l, C-reactive protein of <5 mg/l and erythrocyte sedimentation rate of 36 mm/h. A CT scan of her head was reported as a normal unenhanced CT brain (Figure 1A), with no focal infarct or haemorrha... |
We describe two quasi trivial, “old fashioned” [1], but cleverly conceived, undisputable, experiments which disprove Kennard-type absolutistic interpretations of unipolar machines [2,3]. Our findings are in agreement with Weber’s statements concerning the role of relative motion in electrodynamics [4], as advanced by h... |
Acute exposure to bright light at night reduces the nocturnal decline of core body temperature (cBT) and inhibits melatonin secretion in men. Since inhibition of melatonin secretion by beta-adrenergic blockade reduces the nocturnal decline of cBT by 40% in women, experiments were performed to investigate whether the th... |
Clinical trials are crucial in determining whether novel medical interventions are effective and safe. The use of human participants in such trials is also vital, as animal testing and computer simulation are no substitutes for testing people. Regulation aimed to ensure ethical and safe practices when using human parti... |
This study assessed the long‐term annual biofuel production capacity potential and price in the United States and shed light on the prospect of biofuel adoption for marine propulsion. A linear programming model was developed to assist the projections and provide insightful analyses. The projected long‐term (2040) maxim... |
Nonsteroidal antiinflammatory drugs (NSAIDs), one of the most widely used classes of drugs in the world, are effective antiinflammatory, analgesic, and antipyretic agents. Although they differ from one another in chemical class, all inhibit the synthesis of prostaglandins. Because prostaglandins serve a variety of phys... |
This paper presents a compilation of information on the history and features of thermo-electric coolers, infrared detectors and their combination into detector/cooler packages. It shows their potential for utilization as the thermal infrared sensors in those measurement devices related to the problems of energy conserv... |
A kinetic study on the alkaline hydrolysis of cefotaxime at pH 10.5 and 37 degrees C has been carried out by using HPLC and 1H NMR. The main resulting degradation products have been isolated and identified. These include, apart from the well-known deacetylcefotaxime, the exocyclic methylene derivative, the 7-epimer of ... |
HYPOTHESIS |
Magnetic vestibular stimulation (MVS) elicits nystagmus in C57BL/6J mice but not head tilt mice lacking Nox3, which is required for normal otoconial development. |
BACKGROUND |
Humans have vertigo and nystagmus in strong magnetic fields within magnetic resonance imaging machines. The hypothesized mechanism is a Lorentz force driven by electrical current entering the utricular neuroepithelium, acting indirectly on crista hair cells via endolymph movement deflecting cupulae. We tested an altern... |
METHODS |
Before MVS, vestibulo-ocular reflex responses of eight C57BL/6J mice and six head tilt mice were measured during whole-body sinusoidal rotations and tilts using video-oculography. Mice were then placed within a 4.7 Tesla magnetic field with the horizontal semicircular canals approximately Earth-horizontal for ≥1 minute... |
RESULTS |
Outside the magnet, both C57BL/6J and head tilt mice had intact horizontal vestibulo-ocular reflex, but only C57BL/6J mice exhibited static counter-roll responses to tilt (normal utiruclo-ocular reflex). When placed in the magnet nose-first, C57BL/6J mice had left-beating nystagmus, lasting a median of 32.8 seconds. Wh... |
CONCLUSIONS |
C57BL/6J mice generate nystagmus in response to MVS, while mice deficient in Nox3 do not. This suggests 1) a normal utricle is necessary, and 2) functioning semicircular canals are insufficient, to generate MVS-induced nystagmus in mice.Universal Bufferless Packet Switching |
A packet-switching algorithm specifies the actions of the nodes in order to deliver packets in the network. A packet-switching algorithm is universal if it applies to any network topology and for any batch communication problem on the network. A long-standing open problem has concerned the existence of a universal pack... |
The aim of the present study was to evaluate the effect of DAU 6215 (N-(endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2, 3-dihydro-2-oxo-1H-benzimidazol-1-carboxamide, hydrochloride), which is a 5HT-3 receptor antagonist, chemically different from the other 5HT-3 antagonists, on a wide variety of animal models sensitive t... |
While definitions for, and assessments of, the quality of degree programs in higher education are varied, in criminal justice the field has determined a quality program is one that meets certain standards involving such areas as program mission, curriculum, faculty credentials, and resources determined through “academi... |
A university is expected to continue to develop through various periods of change and innovation to remain at the forefront in the field of information technology, and always produce graduates who are ready to apply and have quality. A university's commitment to quality, has pushed to implement a quality management sys... |
A 60‐year‐old man with bilateral lung metastases from breast cancer was treated with the gonadotropin‐releasing hormone analogue, buserelin, given as an intranasal spray. Androgen deprivation and complete remission of lung metastases were achieved with minimal side effects. Androgen deprivation by means of nasally admi... |
State legislatures enacted less fertility-related legislation in 1980 than in any year since 1972. 28 new laws were passed in 1980, compared to 61 in 1979. The drop in new laws was caused by a lack of abortion legislation. From 1973, when the Supreme Court legalized abortion, through 1980, states have passed a total o... |
[Determination of the minimal length DNA homologous region required for plasmid integration into the Bacillus subtilis chromosome via homologous recombination]. |
With a view to determine a minimal sequence length of homology necessary for RecE-dependent homologous recombination in Bacillus subtilis cells, we developed a system, based on interaction between plasmid replicon and bacterial chromosome. Recombination frequencies were measured between ts plasmid pE194 derivatives car... |
Spontaneous intracranial hypotension (SIH) has been increasingly characterized in recent years. A definitive diagnostic algorithm remains controversial because several symptoms are often found to be nonspecific. When neuroimaging fails to identify a cerebrospinal fluid leak and symptoms are atypical, an epidural blood ... |
In much of Sub-Saharan Africa, demand for fertilizer was developed based on “cash-crop” systems, usually based on non-cereal export crops — cotton, tea, coffee, fruits, vegetables, and tobacco. In these systems, there is credit for fertilizer and profitable and stable outlets for the product for both smalland large-sca... |
A control group of rats was exposed to filtered air and an experimental group to nitrogen dioxide levels of 15 ppm. Surface tension-area curves were recorded from fresh lung washings of excised lungs. Total phospholipid and lecithin concentrations were determined as an index of surfactant quantity, and an analysis of t... |
The increasing use of social networks via touch screen interfaces on smartphones and tablets has brought enormous benefits to the mobile applications usability. However, access to information via these devices represents a new challenge of interaction for users with visual impairments. In this context, this paper descr... |
The effects of dietary gentian violet upon certain physiological parameters of broiler chickens were studied. Gentian violet exhibited no effect upon growth rates or feed conversion ratios at dietary levels of 16, 32, or 64 micrograms/g. In vitro intestinal absorption of methionine and glucose was also unaltered. Dieta... |
The hybrid utilization of photovoltaic and wind turbine, known as the wind-solar hybrid power system (WSHPS), is one of the most promising renewable energy technologies for satisfying the power load demand, since they have complementary energy generation profiles and reduced capacity for energy storage. This paper demo... |
ical content of Eddy's thought and of Christian Science, Gottschalk has consistently maintained in his writings that Eddy is a Christian thinker and that Christian Science is indeed Christian, but it is neither Catholic nor Protestant. In the concluding "Coda: The Prophetic Voice," Gottschalk characterizes Eddy as a re... |
Purpose: To evaluate the effect of saliva contamination on shear bond strength, microleakage, and microstructure of the adhesive interface in two different adhesive systems by using scanning electron microscopy (SEM) and confocal laser microscopy (CLSM). Materials and methods: Randomly, 228 third molars were allocated ... |
Thermoluminescence (TL) of the red-emission band obtained from natural muldan feldspar has shown two main peaks at around 160 and 270 °C, with thermal activation energies of 0.33 and 1.05 eV, respectively. The laboratory-induced TL peaks at 140 °C, 190 °C, 285 °C and 365 °C have thermal activation energies of 0.27, 0.4... |
The experimental measurement of light field correlations is a difficult problem because, even in the monochromatic scalar case, the spatial coherence state of light is described by four-dimensional functions. Additional information about the field symmetry or coherence state allows reduction of the complexity of the pr... |
In a classic paper, Schelling (1971) showed that extreme segregation can arise from social interactions in white preferences: once the minority share in a neighborhood exceeds a critical "tipping point," all the whites leave. We use regression discontinuity methods and Census tract data from 1970 through 2000 to test f... |
Abstract Clinical and pre-clinical studies have shown that early-life adversities, such as abuse or neglect, can increase the vulnerability to develop psychopathologies and cognitive decline later in life. Remarkably, the lasting consequences of stress during this sensitive period on the hypothalamic–pituitary–adrenal ... |
e12565 Background: Therapeutic decisions for the primary treatment of breast cancer is commonly based on the expression profiles of estrogen (ER), progesterone (PR) and the human epidermal growth factor 2 (HER2) receptors. However, breast cancer is a very heterogeneous disease, and receptor changes were manifold report... |
Nucleosome positions within the chromatin landscape are known to serve as a major determinant of DNA accessibility to transcription factors and other interacting components. To delineate nucleosomal patterns in a model genetic organism, Caenorhabditis elegans, we have carried out a genome-wide analysis in which DNA fra... |
This paper presents a link quality model for a wireless communication system with distributed turbo coding and lossy forwarding. The model maps the signal-to-interference-plus-noise ratio (SINR) of packet copies received from different links to a mutual information parameter and, in a second stage, converts it to a blo... |
In this paper, we have proposed a high linearity process angle interference resistant multi-phase output digital control oscillator with negative feedback. The proposed digital control oscillator uses negative feedback structure to improve the output frequency linearity and resist process angle interference, while this... |
Survivorship curves and longevity of workers were studied in two queenright and two queenless colonies of Bombus (Fervidobombus) atratus. Survivorship curves for workers of all colonies were, in general, convex, indicating an increasing mortality rate with increasing age. The mean longevity for the workers from queenri... |
Among profiles, helix and tooth thickness pitch is one of the most important parameters of an involute gear measurement evaluation. In principle, coordinate measuring machines (CMM) and CNC-controlled gear measuring machines as a variant of a CMM are suited for these kinds of gear measurements. Now the Japan National I... |
Abstract Purpose: Dysfunctional breathing (DB) is associated with an abnormal breathing pattern, unexplained breathlessness and significant patient morbidity. Treatment involves breathing retraining through respiratory physiotherapy. Recently, manual therapy (MT) has also been used, but no evidence exists to validate i... |
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