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The flavivirus nonstructural protein 3 (NS3) is a protease and helicase, and on the basis of its similarity to its homologue encoded by the hepatitis C virus (HCV), the flavivirus NS3 might be a promising drug target. Few flavivirus helicase inhibitors have been reported, in part, because few specific inhibitors have b... |
Abstract Cavernous cerebral malformations (CCM) are vascular malformations of the brain and spinal cord. CCM affect up to 0.5% of the general population, predisposing to headaches, seizures, cerebral hemorrhage and focal neurological deficit. CCM may be familial or sporadic. Familial forms have autosomal dominant inher... |
We present 12CO J = 2-1 observations toward the central region of the type 2 Seyfert galaxy NGC 4258 with the Submillimeter Array (SMA). Our interferometric maps show two armlike elongated components along the major axis of the galaxy, with no strong nuclear concentration. The CO(2-1) morphology and kinematics are simi... |
s HORMONE RESEARCH IN PÆDIATRICS Basel • Freiburg • Paris • London • New York • New Delhi • Bangkok • Beijing • Tokyo • Kuala Lumpur • Singapore • Sydney HRP_2011_076_S02_tivo.indd I 01.07.2011 11:02:11 This publication was sponsored by Eli Lilly and Company Ferring Pharmaceuticals Ipsen Merck Serono S.A. Novo Nordisk ... |
to spirit him away, Alice-like, to a whimsical tea party with other forest creatures. As the sun rises, the boy rides his bike home, where he has a story to tell and feels a little less alone. Miyares’ minimal, hand-lettered text lets his luminous gouache and colored pencil illustrations take center stage for the story... |
In recent years, continuum robots have gained significant momentum in terms of technological maturity and clinical application. Their flexibility allows complex treatment sites to be reached with minimal trauma to the patient. However the reliable control of continuum robots is still an ongoing research issue in the ro... |
The article addresses the state and trends in the development of wages in trade and the distribution system in particular. The importance of the research is emphasized by the fact that the most significant transformations in the conditions of market development take place in the social and labor domains. The main purpo... |
BACKGROUND |
Pakistan has one of the highest prevalence of poisoning in the world. However, limited data exist on the frequency of poisons implicated in homicidal, suicidal, and accidental cases in North-West Pakistan (Khyber Pakhtunkhwa). |
METHODS |
This retrospective study of 353 cases and biological specimens of poisoning received at the department of Forensic medicine and toxicology, Khyber Medical College Peshawar from 13 districts of Khyber Pakhtunkhwa. Frequency of poisoning was assessed by testing each specimen for 17 different poisons. |
RESULTS |
Of all the specimens, 250 (70.8%) specimens tested positive and the rest didn't show any indication of poisoning (n=103, 29.2%). The most frequent poisons detected were benzodiazepines (total n=75), organophosphates (total n=58), phencyclidine (total n=30) and morphine (total n=23). Gender had a significant association... |
CONCLUSIONS |
Poisoning by benzodiazepines, organophosphates and phencyclidine are the most common causes of intoxication in population of Khyber Pakhtunkhwa. Source of poisoning varies with gender for organophosphates, benzodiazepines and tricyclic antidepressants.Construction of the Qur’anic Values as the Basis for Islamic Educa... |
The present study aims to elucidate the construction of the values of the Qur’an ​​as the basis for the Islamic education development based on Abdullah Saeed’s thought. The concept of a hierarchy of values initiated by Abdullah Saeed is a continuation of Rahman’s general principles, proposing a new way of loo... |
Image compression using a new adaptive standard deviation thresholding estimation at the wavelet details subbands |
The process before quantization stage in compression process is a very crucial stage espeacially in application that require a high compression ratios. So, in this paper, we propose a new method of image compression that is based on reducing the wavelet coefficients in wavelet details subbands. It is based on the conce... |
Abstrack. Electricity plays a critical role in telecommunication business. Information transmission service infrastructure such as base transceiver stations (BTSes), base station controllers, and mobile switching centers must not lose electricity supply. Therefore, telecommunication enterprises have gensets as backup p... |
Metal gate MOS-transistors with channel lengths down to approximately 0.5 μm and with gate oxide thicknesses of 19 nm and 34 nm have been fabricated and evaluated. For devices shorter than 1 μm we have found significant short channel effects on threshold voltage, transconductance and subthreshold current. The experimen... |
In this paper, number-theoretic and algebraic aspects of a choice of the block diagram of the IIR digital filter are considered. It is supposed that generation of structures of digital filters is carried out. The structure of the filter is described by a topological matrix of transfer coefficients between block diagram... |
We have examined the collagenous proteins extracted from skin and produced by skin fibroblast cultures from the members of a family with mild dominant osteogenesis imperfecta (OI type I). The two affected patients, mother and son, produce two populations of alpha 1(I) chains of type I collagen, one chain being normal, ... |
A metaphor is the expression of a concept or a phenomenon by a person by using analogy in the sense that s/he perceives. This study was conducted for the purpose of finding the mental images (i.e. the metaphors) which social studies teacher candidates have on Web 2.0 technology. The study group consisted of 77 social s... |
A series of Tb3+- and Eu3+-doped Ca8ZnLu(PO4)7 (CZLP:Tb3+ and CZLP:Eu3+) as well as Ca8ZnTb(PO4)7:Eu3+ (CZTP:Eu3+) phosphors have been prepared via the traditional high-temperature solid-state reaction. X-ray powder diffraction (XRD) patterns of the as-prepared phosphors indicate that the introduction of Tb3+ or Eu3+ a... |
In this work, a fast FPGA implementation of an optimized receiver diversity combining technique, termed Generalized Maximal Ratio Combining (GMRC), is implemented for signal transmission over wireless Single-Input-Multiple-Output (SIMO) fading channels. One prior published FPGA implementation applied brute-force techni... |
The Supreme Court's 2007 Leegin decision provided that minimum resale price maintenance (RPM) agreements are to be evaluated under the rule of reason. However, the Court's rule of reason analytical approach does not provide clear guidance for practitioners to advise clients considering the adoption of such programs. Th... |
In a multicentre study of the German Contact Dermatitis Research Group, sodium lauryl sulfate (SLS) 0.25% and 0.5% aq. has been added to routine allergen patch tests to assess its properties as a convenient diagnostic indicator of individual susceptibility to irritation at the time of patch testing. Previous studies in... |
AIMS |
The clinical predictors and outcomes of patients with cardiogenic shock (CS) requiring renal replacement therapy (RRT) have not been studied previously. This study assesses the impact of RRT on mortality in patients with CS and aims to identify clinical factors that contribute to the need of RRT. |
METHODS AND RESULTS |
Consecutive patients presenting with CS were included from a prospective registry of cardiac intensive care unit admissions at a single institution between 2014 and 2020. Of the 1030 patients admitted with CS, 123 (11.9%) received RRT. RRT was associated with higher 1-year mortality [adjusted hazard ratio = 1.62, 95% c... |
CONCLUSIONS |
RRT is associated with worse outcomes, including a lower likelihood to receive advanced heart failure therapies in patients with CS. A risk score comprising five variables routinely collected at admission can accurately estimate the risk of needing RRT.Improving communication for distributed model checking |
We examine the distributed breadth-first enumeration of a state space that is partitioned using a static partition function. Two of the key drawbacks of this approach are the high communication overhead and the excessive growth of the queues that hold states received from other nodes, ultimately resulting in memory exh... |
In previous sections we have been been concerned with time dependent initial value problems where we start with some assumed initial condition, calculate how this solution will change in time and then simply march through time updating as we go. We have considered both explicit and implicit schemes, but the basic point... |
In this paper, we prove the existence and uniqueness of a positive solution of nonlinear Hadamard fractional differential equations with integral boundary conditions. In the process we employ the Schauder and Banach fixed point theorems and the method of upper and lower solutions to show the existence and uniqueness of... |
Recent investigations into the psychological factors underlying computer programming have focused on the effects of internal documentation and statement indentation on programmer performance [1, 5, 7]. Using memory recall approaches several studies have concentrated on the relationship between logic segments of a progr... |
Since memory organization appears to be a functional psychological process, it seems reasonable to assume that indentation and documentation function as aids to comprehension rather than as organizers for memory [4]. The purpose of this study was to examine experimentally the relationship between documentation, indent... |
Mal de Chagas, a tropical infection, is a major public health problem in Latin America. The infection can lend to heart disease-chagasic myocarditis-ultimately resulting in arrhythmic death. The high resolution electrocardiogram may offer a means of monitoring the evolution of chagasic myocarditis. The authors attempt ... |
As citizens demand more media literacy education in schools, the criticality of media literacy must be advanced in meaningful and comprehensive ways that enable students to successfully access, analyze, evaluate and produce media ethically and effectively across diverse platforms and channels. Institutional analysis in... |
The essay starts from a “gross grammatical mistake” in the last chapter of Jane Eyre : a reflexive pronoun used as grammatical subject, without any antecedent. The aim of the essay is to show that this is not a grammatical blemish but a stylistic asset. It does so by revisiting the history of reflexive pronouns, by ana... |
Applied cassava starch as raw material, acetic anhydride as the acetylize reagent the acetate starch was prepared by the dry conditions assisted by microwave. The effect of reaction factors such as esterification agent dosage, reaction temperature, reaction time, and system pH value on degree of substitution(DS) and re... |
While these may not all have been statistically watertight studies, they did show a reduced rather than an increased incidence of thromboebolic disease. Hougie2 in an excellent review article quotes the Puerto Rican study3 designed especially to determine the effects of oral contraceptive agents on the incidence of thr... |
W e intend to solve the fully fuzzy linear system of the form and where , and are n x n fuzzy matrices consisting of positive fuzzy numbers , the unknown vector is a vector consisting of n positive fuzzy numbers and the constant are vectors consisting of n positive fuzzy numbers, using decomposition methods.Smooth esti... |
Many types of duration data suffer both from left-truncation and rightcensoring. We show how these deficiencies can be overcome at the same time when estimating the hazard rate nonparametrically by kernel smoothing with the nearest neighbor method. We infer the uniform consistency of the estimate from the Hoeffding ine... |
The Hungarian term bath [fürdő] has several meanings, from personal cleanliness to thermal and mineral water cures. Although bath, bathing and the presence of healing and regenerating waters is rarely encountered in eighteenth-century Hungarian ego-documents in Transylvania, we have a few descriptions regarding persona... |
Henry Glassie, noted American folklorist, describes history as “stories we tell about the past in the present to define our future.”1 Nowhere is that notion of telling a story more poignant or more important than in the recovery and retention of the history of work. Work and workplaces, and the communities that workers... |
OBJECTIVE: To assess the therapeutic effects of cannabis, cannabis-derived products and synthetic cannabinoids for rheumatoid arthritis. DESIGN: This is the protocol of a systematic review. DATA SOURCES: Searches will be conducted in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), tria... |
The authors previously proposed the Context Engineering (CE) approach to Information Systems Development (ISD) as a framework to organise ideas about previous development experience and to guide future research on specific ISD methods and techniques. The goals of the CE approach are: to achieve an understanding of the ... |
We read with extreme interest the study by Cognat et al1 investigating the in vivo functionality of the Arg169Cys archetypal mutation in NOTCH3 . In particular, they broaden our knowledge on cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mechanism showing that white... |
Contrary to conventional wisdom, the doors did not suddenly slam shut on American immigrants when Congress passed the Emergency Quota Act of May 1921. Rather, the United States started imposing restrictions a half century earlier. Argentina, Australia, Brazil, and Canada enacted similar measures, although the anti-immi... |
Learning Objectives: Post reperfusion syndrome (PRS) is a major and potentially lethal intraoperative event occurring in 20% of patients undergoing liver transplantation (LTx). PRS is characterized by significant hypotension and bradycardia following allograft implantation and it’s mainly exacerbated by ischemia-reperf... |
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