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Very few data-driven methods for dynamic biological networks reconstruction from gene expression data evaluate the statistical significance of a model. A hypothesis testing procedure examining the goodness of fit of trajectory-based modeling is designed, in contrast to transition-based model fitting. The former has sub... |
The analysis of different types of non-periodic multi-cavity laser structures will be presented. Deterministic non-periodic cavity concepts such as self-similar Cantoror quasi-periodic Fibonacci sequences offer a distinct mode selectivity whilst having a signi®cantly lower number of coupled cavities compared to an equi... |
The advent of Internet of Things (IoT) technology exponentially increases the collection of new information types in consumers’ lives from various sensors. However, many consumers do not fully recognize the potential privacy and security risks (PSR) associated with IoT. Those who are aware rarely take action to protect... |
Enzymatic hydrolysates were prepared from royal jelly using three enzymes (pepsin, trypsin, and papain), and their antioxidative properties were evaluated. The yield of these hydrolysates was very high, about 20-26% on a raw weight basis. In comparison with the antioxidative activities of water extract and alkaline ext... |
Given a social network, which of its nodes are more central? This question has been asked many times in sociology, psychology and computer science, and a whole plethora of centrality measures (a.k.a. centrality indices, or rankings) were proposed to account for the importance of the nodes of a network. In this paper, w... |
Capillary electrophoresis (CE) was employed for studying the complexation of an azacryptand with nitrate and nitrite in aqueous solution. CE separation of a mixture of nitrate and nitrite with 10 mM acetate buffer (pH 3.3) showed two peaks at the retention times of 2.8 and 3.1 min for nitrate and nitrite, respectively.... |
In this study, FeAl2 and Fe2Al5 intermetallic alloys were prepared by conventional casting technique. In order to study their structural stability the alloys were subjected to high-energy ball milling process for 1, 2.5, 5 and 10 h. The structural and chemical characterizations were conducted by X-ray diffraction, scan... |
We investigate electron transmission through a short wire with electron-electron interactions which is coupled to noninteracting metallic leads by tunneling matrix elements. We identify two temperature regimes (a) T Kondo < T ≤ T wire = ¯ hv F /k B d ( d is the length of the interacting wire) and (b) T < T Kondo ≪ T wi... |
In Elastic Optical Networks (EONs), elastic operations have been constrained by the assumption that an optical signal has to occupy a dedicated frequency range, with no sharing of spectrum resources with other independent optical signals. Recently, the emergence of signal overlap techniques can break this traditional c... |
As far as we know, Cr2Si2Te6 is the first compound exhibiting a quasi-2D Ising ferromagnetic behaviour (Tc = 32 K): elastic-neutron-scattering experiments on a single crystal and close examination of the thermal evolution of the order parameter led to the critical exponent β ≈ 0.17, comparable to the expected one for a... |
Lin Richards, Nola Wood and Luisa Ruiz-Calzada investigated the current level of emotional and behavioural need and pre- and post-care experiences for children placed in one local authority social care department permanent placement team. A cohort of 41 looked after children was assessed by foster carers, teachers and ... |
Many patients, even cancer patients do not take their medication at all or at the prescribed dose showing thus a form of noncompliance. Reasons for this are manyfold and differ from patient to patient. They may undergo dynamic changes in the course of disease. Experience shows, that compliance is mainly improved when p... |
A simulation study on the ECG is performed using the measured thorax geometry of a healthy subject and a measured ventricular activation sequence, known from the literature. Resulting QRS waveforms are compared with those actually measured on the subject. An adapted activation sequence is derived which, while differing... |
A three-dimensional quantitative structure activity relationship using the eigen value analysis (EVA) paradigm applied to 41 HIV-1 integrase inhibitors that inhibit integrase mediated cleavage (3'-processing step) and integration (3'-strand transfer step) in vitro was performed. The training set consisted of 35 molecul... |
In this paper we present algorithms for designing fault-detection experiments for sequential machines with special emphasis on the case in which the machine does not possess a distinguishing sequence. The length of an experiment is reduced through: 1) identifying each state with its own unique input/output set rather t... |
The sequestration of uranium, particularly from the deposited bones, has been an incomplete task in chelation therapy for actinide decorporation. Part of the reason is that all previous decorporation ligands are not delicately designed to meet the coordination requirement of uranyl cations. Herein, guided by DFT calcul... |
<p>There are many fundamental questions about the temporal and spatial structure of turbulence in space plasmas. Answering these questions is complicated by the multi-scale nature of the turbulent transfer of mass, momentum, and energy, with characteristic scales spanning many orders of magnitude. The solar wind is an ... |
Brassinosteroid (BR) is a class of polyhydroxysteroids plant hormones known to regulate shoot and root growth. Genetic and molecular analyses demonstrate that receptor kinase BRI1 protein acts as a perceiver for BR. One of the characteristics of bri1 mutant’s phenotypes is the complete BR insensitivity in the root. Bio... |
Abstract This article is concerned with the attitudes of the nascent Russian ‘middle class’ towards the privatisation of housing. It focuses on the questions of whether private ownership had an impact on these people's understanding of ‘home’, whether it resulted in greater satisfaction with their housing, and whether ... |
CuFeO 2 is a well known antiferromagnetic material with its geometrically frustrated antiferromagnetic (AFM) [T N =11K] crystal. Besides, delafossite CuFeO 2 oxide crystal is known to be nonstoichiometric under the influence of oxygen as a result of the change in cation valence bands. In this study, boron atoms were su... |
Abstract Social tolerance enables heterogeneous persons to find harmony in their differences. This has been shown to reduce the likelihood of inter- and intra-group conflicts, thereby creating an environment conducive for economic and social development. This paper examines socio-economic factors that influence individ... |
As the IC technology scales down, the effect of IR drop/ground bounce becomes increasingly significant. IR drop and ground bounce can compromise the gate driving capability and degrade the IC performance, and even can make IC functional failures. Hence, it is crucial to capture this effect efficiently and accurately in... |
By utilizing the vapor pressure difference between high-salinity and lowsalinity wvater, one can obtain power from the gradients of salinity. This scheme eliminates the major problems associated with conversion methods in which membranes are used. The method we tested gave higher conversion efficiencies than membrane m... |
Guillain-Barré syndrome (GBS) is a postinfectious autoimmune neuropathy and anti-ganglioside antibodies (Abs) are strongly associated with this disorder. Several studies have implied that specific anti-ganglioside Abs induce neuropathy in patients with axonal forms of GBS. To study the mechanisms of anti-ganglioside Ab... |
In order to form a SiGe thin film by chemical vapor deposition (CVD) with a suitable quality for advanced devices, the relationships between materials/process and structure/composition are needed to be clarified at the atomic level. We simulated SiGe CVD by using reactive force-field (ReaxFF) molecular dynamics simulat... |
Cloud Computing enables customers with limited computational resources to outsource their large computation workloads to cloud, and economically enjoy the massive computational power, bandwidth, storage, and even appropriate software that can be shared in a pay-per-use manner. Security is the primary obstacle that prev... |
Background Arboviral infections are a public health concern and an escalating problem worldwide. Estimating the burden of these diseases represents a major challenge that is complicated by the large number of unapparent infections, especially those of dengue fever. Serological surveys are thus required to identify the ... |
In the last decades, designs of most incandescent sources have been realized by heating the whole device. Here we propose a novel approach consisting in taking advantage of hot nanoemitters that can be cooled in a few tens of nanoseconds. It offers a new opportunity for high speed modulation and for enhanced agility in... |
Diabetes has become a global chronic disease and alpha-glucosidase inhibitors is an effective ways of treating it. Flavonoids are a group of substances in mulberry leaves that have α-glucosidase inhibitory properties and can reduce blood glucose concentrations effectively. In this paper, flavonoids from mulberry leaves... |
Purpose of review Hospitalizations for COVID-19 dramatically increase with age. This is likely because of increases in fragility across biological repair systems and a weakened immune system, including loss of the cardiorenal protective arm of the renin--angiotensin system (RAS), composed of angiotensin-converting enzy... |
James Malley, a local dairy farmer-come-naturalist, |
and I, have been looking for the thylacine for the past 6 |
years or so. In that time we have spent about two years |
each on field trips, mostly in the northern half of Tasmania |
and on the south-west coast. Our major sponsors have been |
the Australian Conservation Foundation, the "Australian" |
newspaper, the Science and Industry Endowment Fund and the |
British Tobacco Company. Since June this year, with the |
assistance of Dr. Robert Brown, we have been conducting |
what we intend to be an exhaustive investigation of northeastern |
Tasmania while investigating any leads that may come |
from elsewhere in the State.Inhibition of cyclin-dependent kinase phosphorylation of FOXO1 and prostate cancer cell growth by a peptide derived from FOXO1. |
Increasing evidence suggests that FOXO1 possesses a tumor suppressor function. Inactivation of FOXO1 has been documented in many types of human cancer, and restoring the activity of FOXO1 holds promise for cancer treatment. In this study, we identified a FOXO1-derived peptide termed FO1-6nls that inhibits cyclin-depend... |
Background: Depression frequently accompanies Parkinson’s disease (PD) and may have a negative impact on activities of daily living, cognitive performance, and quality of life. Because of the symptom overlap between the 2 disorders, it may be difficult to recognize depression in PD. Moreover, the partially shared patho... |
Abstract Introduction Patient registries are an invaluable resource for furthering the understanding of rare diseases such as bleeding disorders, providing large, pooled datasets not achievable by other means of data collection. As well as supporting clinical care and research, registries must also be able to answer qu... |
The Ewing's sarcoma cell line TC71 overexpresses vascular endothelial growth factor isoform 165 (VEGF165), a potent proangiogenic molecule that induces endothelial cell proliferation, migration, and chemotaxis. CD34+ bone marrow stem cells can differentiate into endothelial and hematopoietic cells. We used a transplant... |
The present work was undertaken in order to determine the content of lead, cadmium, copper and zinc in 26 teeth retrieved from burial-grounds in various parts of Norway, dated from A.D. 200 up to 1850. The analyses were made by differential pulse stripping voltammetry on hydrochloric acid digests of the teeth. High lev... |
In this paper, the influence of deposition conditions and post annealing upon the device performance of sputtering-deposited TiN/AlO/AlGaN/GaN metal-oxide-semiconductor heterostructure field-effect transistors is reported. The metal-oxide-semiconductor structure on GaN with AlO deposited in a medium O2/Ar ratio possess... |
Understanding the cellular and molecular mechanisms that specify cell lineages throughout development, and that maintain tissue homeostasis during adulthood, is paramount towards our understanding of why we age or develop pathologies such as cancer. Epigenetic mechanisms ensure that genetically identical cells acquire ... |
Covering: 2000 to 2020Natural products and their derivatives are commercially important medicines, agrochemicals, flavors, fragrances, and food ingredients. Industrial strategies to produce these structurally complex molecules encompass varied combinations of chemical synthesis, biocatalysis, and extraction from natura... |
We thank Hamamatsu et al . (2014) for their thoughtful and prompt response, as well as the additional analysis that they have provided. We agree that secondary sex ratio (SSR) declines are widely reported following periods of parental stress, with the role of both maternal uterine conditions and paternal sperm motility... |
As many as 195 patients with rheumatoid arthritis (RA) were examined for the clinical characteristics of the disease course depending on the presence or lack of antibodies to DNA or of antinuclear factor (ANF). Provided the patients' blood serum contained antibodies to DNA and ANF, RA was noted to run a graver course a... |
The workshop on the evaluation of collaborative information retrieval and seeking (ECol) is held in conjunction with the ACM SIGIR Conference on Human Information Interaction & Retrieval (CHIIR) in Oslo, Norway. To make the workshop active and the participant pro-active, we released datasets and tools so as to help res... |
The purposes of this article were to 1) provide an overview of the science of physical activity-related energy expenditure in older adults (≥65 yr), 2) offer suggestions for future research and guidelines for how scientists should be reporting their results in this area, and 3) present strategies for making these data ... |
Neuropeptides B and W (NPB and NPW) have been identified as endogenous ligands of the G protein-coupled receptors (GPR) 7 and 8, which in humans are expressed in the hypothalamus and probably involved in the regulation of energy homeostasis and feeding behavior. GPR8 is absent in the rat, where the GPR8-like receptor (... |
In this paper, we propose OFDMA/TDD/MIMO system with spatial scheduling, showing frame structure and control procedures to achieve the proposed system. The frame structure includes all functions required for spatial scheduling in a subband of 200kHz and in a frame time of 2.5ms. We show that the frame structure can be ... |
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