| --- |
| license: mit |
| library_name: pyaging |
| tags: |
| - pyaging |
| - aging-clock |
| - biology |
| - dna-methylation |
| --- |
| |
| # grimage |
|
|
| Age-calibrated mortality-risk estimator built in two stages from DNAm surrogates for plasma proteins and smoking pack-years, chronological age, and sex. |
|
|
| | | | |
| |---|---| |
| | **Predicts** | mortality risk | |
| | **Species** | Homo sapiens | |
| | **Tissue** | whole blood | |
| | **Data type** | DNA methylation | |
| | **Model type** | two-stage elastic net + Cox regression | |
| | **Year** | 2019 | |
|
|
| ## Use with pyaging |
|
|
| ```python |
| import pyaging as pya |
| |
| pya.pred.predict_age(adata, ["grimage"]) |
| ``` |
|
|
| Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io). |
|
|
| ## Citation |
|
|
| Lu, Ake T., et al. "DNA methylation GrimAge strongly predicts lifespan and healthspan." Aging (Albany NY) 11 (2019): 303–327. |
|
|
| https://doi.org/10.18632/aging.101684 |
|
|
