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cardiovascular disease is the leading cause of mortality in many economically developed nations accounting for about 30% of all deaths and its incidence is still increasing .
ongoing research aims to investigate and prevent the early development of cardiovascular risk factors such as atherosclerosis , hypertension ... | phospholipids play an essential role in cell membrane structure and function .
the length and number of double bonds of fatty acids in membrane phospholipids are main determinants of fluidity , transport systems , activity of membrane - bound enzymes , and susceptibility to lipid peroxidation .
the fatty acid profi... | pubmed |
our understanding of h pylori induced inflammation leading to cancer is built on the work of 3 pioneering pathologists ( figure 1 ) .
rudolf virchow , a 19th century prussian physician - scientist , is widely regarded as the father of modern pathology . among his many contributions to outlining the scientific basis... | gastric cancer has long been recognized to be accompanied and preceded by chronic gastritis , lasting decades .
arguably , the most important development in our understanding of gastric cancer pathogenesis over the past 50 years has been the realization that , for most cases of gastric cancer , helicobacter pylori is... | pubmed |
neovascular age - related macular degeneration ( namd ) is a leading cause of visual loss among elderly population [ 1 , 2 ] . before the introduction of intravitreal antivascular endothelial growth factor ( anti - vegf ) agents for the treatment of namd , only prevention from visual acuity loss
might have been achie... | purpose . to compare the efficacy of intravitreal bevacizumab versus ranibizumab in the treatment of neovascular age - related macular degeneration ( namd )
.
methods .
retrospective , comparative study .
the newly diagnosed namd patients who were treated with intravitreal bevacizumab or ranibizumab on an as - ... | pubmed |
preeclampsia ( pe ) is a leading cause of maternal and neonatal mortality and morbidity , complicating 25% of all the pregnancies .
classically , the presence of proteinuria in women with gestational hypertension is clinically diagnosed as pe and is associated with increased maternal or neonatal morbidity and mortali... | background : the aim of this study was to evaluate maternal and perinatal outcomes in preeclampsia ( pe ) , according to the value of albumin.materials and methods : preeclamptic women were retrospectively divided into mild hypoproteinemia ( mhp , n = 220 ) and severe hypoproteinemia ( shp , n = 79 ) pe according to th... | pubmed |
the generation of a humanized monoclonal antibody ( mab ) that inhibits the interaction of vegf - a with its receptors vegfr-1 and vegfr-2 and the development of small - molecule protein tyrosine kinase ( ptk ) inhibitors to the cytoplasmic regions of the vegf receptors have provided avenues to explore the efficacy of ... | the vascular endothelial growth factor ( vegf ) family of soluble protein growth factors consists of key mediators of angiogenesis and lymphangiogenesis in the context of tumor biology .
the members of the family , vegf - a ( also known as vegf ) , vegf - b , vegf - c , vegf - d , and placenta growth factor ( pigf ) ... | pubmed |
malaria is still one of the main sources of consideration for public health in many countries including iran , particularly in south and southeast regions of the country .
deliberate implementation of control measures has resulted in a substantial reduction of malaria incidence in iran in recent years ( 1 ) , therefo... | background : the aim of this study was to detect low parasite and asymptomatic malaria infections by means of three malaria diagnostic tests , in a low transmission region of minab district , hormozgan province , southern iran.methods:blood samples of 200 healthy volunteers from bagh - e - malek area were evaluated usi... | pubmed |
over the last two decades many new immunotherapy approaches to the treatment of cancer have entered clinical development due to the increased understanding of the mechanisms of antigen presentation , lymphocyte recognition , functions of the innate immune system , and the means of regulation of these responses and the ... | we previously demonstrated that igg responses to a panel of 126 prostate tissue - associated antigens are common in patients with prostate cancer . in the current report we questioned whether changes in igg responses to this panel might be used as a measure of immune response , and potentially antigen spread , follow... | pubmed |
it is known that bone mass density and architecture are intimately dependent upon mechanical factors .
several in vitro studies suggest that cell mechanical stimulation promotes proliferation and differentiation of osteogenic lineage [ 1 , 2 ] , in agreement with the results from several in vivo studies [ 35 ] .
st... | this in vivo study presents the preliminary results of the use of a novel piezoelectric actuator for orthopedic application .
the innovative use of the converse piezoelectric effect to mechanically stimulate bone was achieved with polyvinylidene fluoride actuators implanted in osteotomy cuts in sheep femur and tibia ... | pubmed |
the study was conducted in the department of oral medicine and radiology and a cancer centre .
the total sample consisting of 90 individuals was divided into a study group of 60 individuals and a control group of 30 individuals .
the study group had 60 oscc patients ( both male and female ) between the ages of 25 a... | background : oral cancer is a result of disordered cellular behavior initiated by various stimuli which is characterized by the alteration of serum glycoproteins consisting of different monosaccharides .
one of these is levo - fucose ( l - fucose ) , a methyl pentose .
elevated levels of protein - bound fucose have... | pubmed |
alan aderem ( institute for systems biology , seattle , washington ) , which were originally generated by dr .
shizuo akira ( research institute for microbial diseases , osaka university , osaka , japan ) .
lcn2 mice were generated by gene targeting in embryonic stem ( es ) cells from mouse strain 129 , and targete... | objectivelipocalin ( lcn ) 2 belongs to the lipocalin subfamily of low molecular mass secreted proteins that bind small hydrophobic molecules .
lcn2 has been recently characterized as an adipose - derived cytokine , and its expression is upregulated in adipose tissue in genetically obese rodents .
the objective o... | pubmed |
male wistar rats ( 10 weeks old ) were obtained from sankyo labo service , co. ltd .
( sapporo , japan ) . each animal was housed in an individual cage in a temperature- and humidity - controlled room with unlimited food and water and a 12-h light / dark cycle . all animals ( n = 22 ) were given 0.3-mg / kg lps ( fro... | the hip joint is one of the major structures in the human body and the resultant force acting through the hip joint is 300% of body weight .
therefore , weight bearing , as a cause of ischaemia , may contribute to the development of non - traumatic osteonecrosis of the femoral head ( onfh ) .
however , it remains u... | pubmed |
with the global debates around health policy reforms , there have been increasing calls for nurses to be actively engaged in national policy processes [ 13 ] .
first , nurses comprise the majority of the global health care workforce , working closely with patients and their families in a variety of settings .
thus ... | the aim of this study was to critically examine how nurses have been involved in national policy processes in the kenyan health sector .
the paper reports qualitative results from a larger mixed method study .
national nonnursing decision - makers and nurse leaders , and provincial managers as well as frontline nur... | pubmed |
uti is a common problem in infants and young children ( 1 , 2 ) ; however , its frequency , symptoms and causative organisms varies in accordance with sex , age , and gender ( 3 ) . unlike other age groups neonates present with non - specific signs and symptoms ( 4 ) warranting a complete sepsis workup followed by a 7 ... | abstractbackgroundsusceptibility pattern of organisms causing urinary tract infection ( uti ) in neonate would potentially improve the clinical management by enabling clinicians to choose most reasonable first line empirical antibiotics .
this study aimed to this end by studying isolated organisms from neonates with ... | pubmed |
congenital adrenal hyperplasia ( cah ) describes a group of inherited autosomal recessive disorders that cause a deficiency in an adrenal enzyme resulting in altered cortisol and aldosterone secretion .
the most frequent cah variant , accounting for 95% of all affected patients , is 21-hydroxylase deficiency ( 21-ohd... | background : congenital adrenal hyperplasia ( cah ) is an inherited recessive disorder of adrenal steroidogenesis .
the enzymes most commonly affected are 21-hydroxylase .
past reports suggested brain magnetic resonance imaging ( mri ) abnormalities in cah patients , affecting white matter signal , temporal lobe an... | pubmed |
delivery of the human genome draft sequence by publicly funded and corporate projects promises to precipitate significant biomedical advances this century . to rise to this challenge
, biologists must become adept at navigating the vast expanses of genomic dna data that may seem , at first glance , to be devoid o... | the evolutionary history of eukaryotic proteins involves rapid sequence divergence , addition and deletion of domains , and fusion and fission of genes .
although the protein repertoires of distantly related species differ greatly , their domain repertoires do not . to account for the great diversity of domain contex... | pubmed |
over the last 25 years , heart rate monitors have been widely used in sports and sports science . since the development of handy heart rate monitors ( hrms ) with the size of a watch and appropriate flexible chest belts with electrodes to transmit signals wirelessly to the watch , measurement of heart rate ( hr )
has... | recent technical development focused on real - time heart rate monitoring instead of postexercise evaluation of recorded data .
there are several systems on the market that allow direct and real - time monitoring of several individuals at the same time .
the present study compared the systems of polar , acentas , a... | pubmed |
in the 1960s , mcculloch and till proposed three functional characteristics that came to form the definition of stem cells .
their findings supported the hypothesis that a specific population of cells was responsible for propagation and sustained growth in a hierarchical manner , a theory first proposed in the middle... | lung cancer is the leading cause of cancer - related deaths worldwide .
recently , advancements in our ability to identify and study stem cell populations in the lung have helped researchers to elucidate the central role that cells with stem cell - like properties may have in lung tumorigenesis . much of this researc... | pubmed |
tubularized incised plate ( tip ) repair is recommended as the ideal repair for distal penile hypospadias ; it has shown excellent results in the management of primary , redo , distal , and proximal hypospadias .
a number of groups have recently been engaged in studying the plate characters and its impact on the succ... | background : today , tubularized incised plate ( tip ) urethroplasty is the most commonly performed operation for distal and mid - penile hypospadias .
reports from different centers worldwide confirm its nearly universal applicability and low complications rate.aim:evaluation of the urethral plate characters and its... | pubmed |
a biodegradao de materiais que ocorre na cavidade bucal pode interferir na resistncia de unio entre o braquete e o esmalte , causando baixos valores de resistncia de unio in vivo , em comparao aos valores in vitro .
o objetivo do presente estudo foi desenvolver um prottipo para mensurar , in vivo , a fora de descolag... | abstractintroduction : material biodegradation that occurs in the mouth may interfere in the bonding strength between the bracket and the enamel , causing lower bond strength values in vivo , in comparison with in vitro studies . objective : to develop a prototype to measure bracket debonding force in vivo and to evalu... | pubmed |
trichomonas vaginalis infection is one of the most common curable sexually transmitted infections . who estimates that 173 million of new cases occur annually .
trichomonal infection has been associated with adverse reproductive health outcomes including pelvic inflammatory disease , low infant birth weight and pre... | objective . the epidemiology of trichomonas vaginalis infection among sexually active socially - marginalized women in three urban ,
coastal peruvian cities was examined in order to quantify the prevalence of trichomonas infection and identify associated risk factors .
methods .
we conducted a cross - sectional ,... | pubmed |
lennox - gastaut syndrome ( lgs ) , one of the catastrophic epilepsies of childhood , is classified by the international league against epilepsy as a symptomatic generalized epilepsy syndrome . originally described in 1966 , this
tonic seizures ( especially during sleep ) , atonic ( astatic or drop attacks ) seizures... | objective : this review summarizes the treatment of lennox - gastaut syndrome , an intractable epileptic encephalopathy of early childhood . in particular , the review focuses on rufinamide , a recently released anticonvulsant medication with reported effectiveness in this epilepsy syndrome.methods:a systematic literat... | pubmed |
interpopulational variation in sexual chemical signals may provide the basis for premating reproductive isolation and speciation in many animals [ 1 , 2 ] .
phenotypic plasticity in sexual signals could play a key role in initial signal divergence , for example , as a way to maximize the efficiency of signals for com... | interpopulational variation in sexual signals may lead to premating reproductive isolation and speciation .
genetic and morphological studies suggest that the iberian wall lizard , podarcis hispanica , forms part of a species complex with several cryptic species .
we explored the role of chemical sexual signals i... | pubmed |
the scientific activity of a group of researchers is manifested through published papers , which are validated and legitimized by their peers .
these papers can also serve as indicators of the degree to which their scientific knowledge in their area of research has been developed .
the formal means of releasing sci... | introductionthe scientific production of institutions of higher education , as well as the dissemination and use of this published work by peer institutions , can be assessed by means of quantitative and qualitative measurements .
this type of analysis can also serve as the basis of further academic actions .
varia... | pubmed |
according to the who experts , if rubella infection occurs during the early stages of pregnancy , the potential of passing the virus through the placenta and reaching the fetus is about 90% .
the most important complication of rubella is congenital rubella syndrome ( crs ) , which directly relates to lack of immuni... | background : rubella is a mild viral infectious disease , usually occurs subclinically without a serious complication .
but if occurs during pregnancy , specially the first trimester , it can transmit and invade to fetus causing congenital rubella syndrome or fetal death . in 2003 ,
nearly all iranians at the age o... | pubmed |
with the advent of cell type specific molecular markers , description and analysis of developmental morphogenesis has become possible in a number of biological systems .
gene - specific rna probes are now extensively used as they enable visualization of gene expression patterns and thus provide valuable information r... | the photostability and narrow emission spectra of nanometer - scale semiconductor crystallites ( qds ) make them desirable candidates for whole - mount fluorescent in situ hybridization to detect mrna transcripts in morphologically preserved intact embryos .
we describe a method for direct qd labeling of modified oli... | pubmed |
pancreatic cancer is a devastatingly lethal disease , with the highest mortality and the lowest one , three , and five - year relative survival rates of all cancers in the united states.1,2 although pancreatic cancer accounts for a relatively small number of new diagnoses at approximately 44,000 per year , with over 37... | the 18,352 pancreatic ductal adenocarcinoma ( pdac ) cases from the surveillance epidemiology and end results ( seer ) database were analyzed using the kaplan - meier method for the following variables : race , gender , marital status , year of diagnosis , age at diagnosis , pancreatic subsite , t - stage , n - stage ,... | pubmed |
we recruited japanese patients who underwent pta for cli in kansai rosai hospital , hyogo , japan , between 2003 and 2009 .
all patients with chronic ischemic rest pain and/or foot ulcer or gangrene were evaluated for limb ischemia by angiography . the diagnosis and management of cli were compliant with the transatla... | objectiveto reveal the influence of preoperative factors on the prognosis of patients undergoing percutaneous transluminal angioplasty ( pta ) for critical limb ischemia ( cli).reseach design and methodswe recruited 278 japanese patients who underwent pta for cli between 2003 and 2009 .
the outcome measures were mort... | pubmed |
human cystic echinococcosis ( ce ) , caused by echinococcus granulosus , is one of the most important and widespread parasitic zoonoses ( 1 ) .
humans acquire infection by accidental ingestion of e. granulosus eggs voided in the faeces of infected dogs and the disease is common in parts of the world where there is cl... | background : cystic echinococcosis ( ce ) is one of the most important parasitic zoonosis worldwide .
due to the high recurrence rate of the disease after surgery , follow up of the patient is necessary .
the aim of current research was to assess the performance of western blotting ( wb ) , using sheep hydatid flui... | pubmed |
obesity is a common metabolic disease world - wide and dyslipidemias among the most common metabolic disorders associated with obesity [ 17 ] .
obesity is often described by classical parameters such as body mass index ( bmi ) , waist circumference ( wc ) , and waist - to - hip ratio ( whr ) [ 13,7,8 ] .
results of... | backgroundthe aim of this cross - sectional study was to examine the relationship between obesity and lipid markers.material/methodswe divided 66 non - diabetic adult obese patients ( mean age : 55.811.6 years ) into 3 groups according to body mass index ( bmi ) .
all patients were measured for waist circumference ( ... | pubmed |
there has been an explosive growth in the use of internet not only in india but also worldwide in the last decade .
there were about 42 million active internet users in urban india in 2008 as compared to 5 million in 2000 .
the internet is used by some to facilitate research , to seek information , for interpersona... | background : there has been an explosive growth of internet use not only in india but also worldwide in the last decade .
there is a growing concern about whether this is excessive and , if so , whether it amounts to an addiction.aim:to study the prevalence of internet addiction and associated existing psychopatholog... | pubmed |
the frequency response of the resonators was measured using a downmixing method , described in detail in .
the device was electrostatically actuated , and the driving voltage was applied to a side - gate parallel to the resonator . to reduce parasitic signals ,
the drive signal was set to half the actuation frequen... | frequency stability is key to performance of nanoresonators . this stability is thought to reach a limit with the resonator s ability to resolve thermally - induced vibrations .
although measurements and predictions of resonator stability usually disregard fluctuations in the mechanical frequency response , these flu... | pubmed |
cardiovascular disease ( cvd ) is the leading cause of death in the united states . in 2010 , cvds killed over 700 000 americans , and accounted for 29.4% of total deaths .
moreover , cvd accounts for a significant portion of the financial burden of medical care , costing > $ 312.6 billion in healthcare spending and ... | backgroundaspirin use has been shown to be an effective tool in cardiovascular disease ( cvd ) prevention among highrisk patients .
the patientreported physician recommendation for aspirin as preventive therapy among high and lowrisk patients is unknown.methods and resultswe conducted an analysis of the national heal... | pubmed |
mitochondria produce reactive oxygen species ( ros ) during oxidative metabolism through the single - electron reduction of molecular oxygen ( o2 ) .
the resulting superoxide anion ( o2 ) , is converted to hydrogen peroxide ( h2o2 ) by cellular superoxide dismutases ( sods ) .
similar to phosphorylation , ubiquitin... | mitochondrial metabolism has traditionally been thought of as a source of cellular energy in the form of atp .
the recent renaissance in the study of cellular metabolism , particularly in the cancer field , has highlighted the fact that mitochondria are also critical biosynthetic and signaling hubs , making these org... | pubmed |
hepatitis c virus ( hcv ) is a single - stranded rna virus , a member of the flaviviridae family . since the first identification of the hcv genome by choo et al .
, hcv study has progressed mainly in the field of hcv functional analysis and therapeutic implications .
because of low viral levels in the serum , the ... | background . in situ hybridization ( ish ) with high sensitivity has been requested to demonstrate hepatitis c virus ( hcv ) rna in formalin - fixed , paraffin - embedded ( ffpe ) sections of the liver .
methods .
ish employing a locked - nucleic - acid- ( lna-)modified oligonucleotide probe and biotin - free catal... | pubmed |
there are many concerns about endocrine - disrupting chemical effects on wild animals as well as humans
. considerable numbers of chemicals have been shown to alter the thyroid system in vertebrates , and disruption of the thyroid axis has been identified as an important consideration for the regulation of chemicals ... | there are continued concerns about endocrine - disrupting chemical effects , and appropriate vertebrate models for assessment of risk are a high priority .
frog tadpoles are very sensitive to environmental substances because of their habitat and the complex processes of metamorphosis regulated by the endocrine system... | pubmed |
cesarean sections ( cs ) performed following a medical indication is necessary for life - saving .
it is a surgical intervention to prevent maternal or perinatal complications and the appropriate rate of use should be one associated with the lowest rate of maternal and perinatal morbidity and mortality .
however , ... | background : the postpartum period is a critical life event for women leading physical , emotional , and social changes .
postpartum quality - of - life may be affected by delivery mode .
the purpose of this study was to determine the association between postpartum health related quality - of - life ( hrqol ) and m... | pubmed |
maslow 's hierarchy of needs has been a well - known theory since abraham maslow proposed it in 1943 and in his book motivation and personality in 1954 , in which he proposed that human needs can be portrayed in the shape of a pyramid , with the most fundamental levels of needs at the bottom . from bottom to the top ... | safety first , we say these words almost every day , but we all take this for granted for what maslow proposed in his famous theory of hierarchy of needs : safety needs come second to physiological needs . here
we propose that safety needs come before physiological needs .
safety needs are personal security , fina... | pubmed |
an imposing body of
studies , spanning
more than three decades , has cogently elucidated the involvement of
epoxyeicosatrienoic acids ( eets ) in a wide array of critical physiological
functions , inter alia , blood pressure regulation , nociception , adipogenesis , anti - inflammatory activity , organ regenera... | the cytochrome p450 eicosanoid 14,15-epoxyeicosa-5,8,11-trienoic
acid ( 14,15-eet ) is a powerful endogenous autacoid that has been ascribed
an impressive array of physiologic functions including regulation
of blood pressure . because 14,15-eet is chemically and metabolically
labile , structurally related surro... | pubmed |
in response to the increasing demand for an improved healthcare system in the united states , the american academy of family physicians , the american academy of pediatrics , the american college of physicians , and the american osteopathic association developed the joint principles of the patient - centered medical ho... | the patient - centered medical home ( pcmh ) is a primary care model that provides coordinated and comprehensive care to patients to improve health outcomes .
this paper addresses practical issues that arise when transitioning a traditional primary care practice into a pcmh recognized by the national committee for qu... | pubmed |
incremental improvements in the survivorship from cpr occurred as more and more people were trained in cpr and as defibrillators became portable and were deployed in more locations .
finally , most people who had suffered from cardiac arrest did not survive to leave the hospital or did so in a neurological devastated... | background : therapeutic hypothermia has been recommended for the treatment of cardiac arrest patients who remain comatose after the return of spontaneous circulation .
the aim of this study was to evaluate the effectiveness and safety of mild hypothermia on patients with cardiac arrest by conducting a meta-analysis.... | pubmed |
for several years , a male factor has been recognized in the diagnosis and treatment of all infertility ; approximately 40% of marital infertility is due to a male factor .
it is a condition characterized by persistent enlargement and elongation of the pampiniform plexus , venous convolution , and sinus formation wit... | introductionfailure to perform surgical repair of varicocele before puberty is among the common causes of male infertility .
the purpose of this study was to evaluate the testicular volume and fertility potential in men after laparoscopic varicocelectomy conducted in adolescence due to varicocele and concomitant test... | pubmed |
radical retropubic prostatectomy is the surgical treatment of choice for patients with localized prostate cancer .
numerous studies have been published demonstrating excellent tumor control , good functional results , and low morbidity associated with the procedure ( 1 - 4 ) .
however , the major long - term morbid... | we investigated the distribution and navigation of periprostatic nerve fibers and constructed a 3-dimensional model of nerve distribution .
a total of 5 cadaver specimens were serially sectioned in a transverse direction with 0.5 cm intervals .
hematoxylineosin staining and immunohistochemical staining were then pe... | pubmed |
rheumatoid arthritis ( ra ) is a progressive , autoimmune disease , characterized by chronic inflammation of synovial membrane and consistently degradation of articular cartilage and subchondral bone .
serum amyloid a ( saa ) is a highly conserved acute - phase protein , released in response to inflammation or infect... | objectives .
rheumatoid arthritis ( ra ) is a systemic , inflammatory disease .
serum amyloid a ( saa ) is an acute - phase protein , involved in pathogenesis of atherosclerosis .
the aim of the study was to assess serum concentration of saa in ra patients , with reference to other inflammatory parameters and mar... | pubmed |
glucocorticoids have been extensively characterized as being anti - inflammatory and/or immunosuppressive in therapeutic settings and are generally discussed as opposed to the development of inflammation and limiting of production or maturation of some effector immune cell types , in a physiological context .
nev... | exogenously administered glucocorticoids enhance eosinophil and neutrophil granulocyte production from murine bone - marrow .
a hematological response dependent on endogenous glucocorticoids underlies bone - marrow eosinophilia induced by trauma or allergic sensitization / challenge .
we detected a defect in granul... | pubmed |
62.4 million indians were reported to have type 2 diabetes mellitus ( t2 dm ) putting india on the forefront of diabetic epidemic across globe .
fear of hypoglycaemia and gain in body weight are barriers for initiation of insulin therapy .
modern insulin analogues are a convenient new approach or tool to glycaemic ... | background : the a1chieve , a multicentric ( 28 countries ) , 24-week , non - interventional study evaluated the safety and effectiveness of insulin detemir , biphasic insulin aspart and insulin aspart in people with t2 dm ( n = 66,726 ) in routine clinical care across four continents.materials and methods : data was c... | pubmed |
over the past decade , many cell types have been evaluated in an effort to find the best source for cardiac regeneration . of these ,
the most extensively studied have been embryonic stem cells , mesenchymal stem cells , skeletal myoblasts , and bone marrow - derived progenitor cells , while more recent possibilities... | acute ischemic injury and chronic cardiomyopathies can cause irreversible loss of cardiac tissue leading to heart failure .
cellular therapy offers a new paradigm for treatment of heart disease .
stem cell therapies in animal models show that transplantation of various cell preparations improves ventricular functio... | pubmed |
the mineral polyhalite ( chemical formula [ k2ca2mg(so4)4.2h2o ] ) commonly occurs in sedimentary evaporite successions and in rare cases as a sublimate in volcanic successions ( e.g. vesuvius , campania , italy ) ( anthony et al . , 1996 ) .
polyhalite was first described from the salt mine bad ischl - perneck in a... | in the hallstatt salt mine ( austria ) , polyhalite rocks occur in 0.51 m thick and several metre long tectonic lenses within the protocataclasite to protomylonite matrix of the alpine haselgebirge fm .. thin section analysis of hallstatt polyhalites reveals various fabric types similar to metamorphic rocks of crust ... | pubmed |
oxidative stress can be described as an imbalance between the production of free radicals and antioxidant defence . over the last decades ,
it has become amply evident that oxidative stress , usually in the form of reactive oxygen species ( ros ) , is a critical pathogenic factor in the development of several systemi... | in recent years , the activity of anaesthetic propofol on biological processes has been attracting attention .
the effect of propofol on biochemical indices in animals is unknown . in this study
, we examined the effects of propofol on lipid profile , antioxidant indices , and cardiovascular marker ( cvm ) enzymes ... | pubmed |
idiopathic hypogonadotropic hypogonadism ( ihh ) refers to gonadal dysgenesis due to deficiency of gonadotropin - releasing hormone ( gnrh ) release from the hypothalamus .
the prevalence of ihh is about 1/10,000 in men and 1/50,000 in women with a m / f ratio of 4 - 5 : 1 .
since ihh is rare , the number of ihh ... | idiopathic hypogonadotropic hypogonadism ( ihh ) is a rare condition in which puberty does not take place naturally .
we aimed to develop and follow an internet - based cohort and to improve our understanding of the disease .
we established an internet - based questionnaire survey .
a total of 74 male ihh patient... | pubmed |
nonsurgical endodontic retreatment is indicated as the primary choice to eliminate or substantially reduce the microbial content from endodontically failed teeth .
nevertheless , well - compacted root fillings offer resistance to the instruments used for retreatment , leaving root filling residues .
this restricts ... | aim : this study evaluated whether using supplementary files for removing root canal filling residues after protaper universal retreatment files ( rfs ) increased the debris extrusion apically.materials and methods : eighty mandibular premolars with single root and canal were instrumented with protaper universal rotary... | pubmed |
traditionally , maxillary teeth have been anesthetized by administering an injection in the mucobuccal supraperiosteal fold in the proximity to the apices of teeth to be anesthetized .
it is a convenient , safe , and effective way to achieve pulpal anesthesia in maxillary teeth and associated tissues .
the disadvan... | background : dental procedures in the maxilla typically require multiple injections and may inadvertently anesthetize facial structures and affect the smile line . to minimize these inconveniences and reduce the number of total injections , a relatively new injection technique has been proposed for maxillary procedures... | pubmed |
malaria continues to be a serious public health problem in south - east asia including india . about 36% of the world 's population ( 2020 million )
the south - east asian region contributes 2.5 million cases to the global burden of malaria , of which india 's contribution is 76% . according to the world malaria repo... | introduction : an extensive search on pubmed reveals very little in terms of evidence regarding the current knowledge , attitude , and practices ( kap ) of the population in general and rural population , in particular , in this part of the country .
therefore , a study was conducted with the aim to assess the commun... | pubmed |
recent advances in molecular biology and microscopy technologies have enhanced our understanding about the higher - order folding of the genome in an unprecedented manner .
it is now widely accepted that the dynamic folding of the chromatin is fundamental in regulating gene expression and dna replication .
the geno... | abstractthe eukaryotic genome is partitioned into topologically associating domains ( tads ) . despite recent advances characterizing tads and tad boundaries ,
the organization of these structures is an important dimension of genome architecture and function that is not well understood .
recently , we demonstrated ... | pubmed |
when the objective of the study is investigation of count data using some variables , statistical modeling is used . in statistics , poisson distribution is used for investigating the count data if the mean and variance of the distribution are the same . if these two measures are not the same ( variance is larger than ... | background : the number of failed courses and semesters in students are indicators of their performance .
these amounts have zero inflated ( zi ) distributions . using zi poisson and negative binomial
distributions we can model these count data to find the associated factors and estimate the parameters .
this stu... | pubmed |
electrostatic
interactions have been shown to play a vital role
in enzyme catalysis .
these interactions assist in the binding of ligands
and facilitate the enzyme - catalyzed chemical reactions by keeping
the reacting species positioned properly as well as stabilizing the
transition state in some cases .
... | electrostatic interactions play an
important role in enzyme catalysis
by guiding ligand binding and facilitating chemical reactions .
these
electrostatic interactions are modulated by conformational changes
occurring over the catalytic cycle .
herein , the changes in active
site electrostatic microenviron... | pubmed |
magnetic particle imaging ( mpi ) is a new three - dimensional imaging method using static and dynamic magnetic fields to visualize the distribution of superparamagnetic iron oxide nanoparticles ( spios).1 imaging relies thereby on three characteristics of the spio , ie ; their superparamagnetic nature , their nonlinea... | backgroundmagnetic particle imaging ( mpi ) uses magnetic fields to visualize superparamagnetic iron oxide nanoparticles ( spio ) . today
, resovist is still the reference spio for mpi .
the objective of this study was to evaluate the in vivo blood half - life of two different types of resovist ( one from bayer pha... | pubmed |
intracellular pathogens have evolved over many millions of years to coexist in the face of a wide array of host defense mechanisms . in vitro studies of the host - pathogen interaction
exclude the inflammatory milieu , but a major challenge in studying the host response in vivo is dissecting pathogen - specific res... | summaryintracellular pathogens modulate host cell function to promote their survival . however , in vitro infection studies do not account for the impact of host - derived inflammatory signals .
examining the response of liver - resident macrophages ( kupffer cells ) in mice infected with the parasite leishmania don... | pubmed |
the control of appetite is complex and involves the coordination of inputs from both physiological and environmental sources .
early theoretical approaches were based on the idea that the control mechanism was dedicated exclusively to signals from glucose metabolism , amino acids or proteins , or adipose tissue . res... | a long - running issue in appetite research concerns the influence of energy expenditure on energy intake .
more than 50 years ago , otto g. edholm proposed that the differences between the intakes of food [ of individuals ] must originate in differences in the expenditure of energy .
however , a relationship bet... | pubmed |
one of the most widely available materials in prosthetic dentistry is polymethyl methacrylate ( pmma ) , a material that has been used as a denture base since 1937 .
heat - polymerized pmma resin is used as a denture base material because of its excellent esthetics , low water sorption and solubility , relative lack ... | background : debonding of denture teeth from denture bases is the most common failure in removable dentures . the purpose of this study was to evaluate the effect of surface treatments on shear bond strength of denture teeth to heat - polymerized and autopolymerized denture base resins.materials and methods : in this e... | pubmed |
the light emitted during arc welding contains intense ultraviolet radiation ( uvr ) . in the absence of a barrier ,
this radiation is emitted into the surrounding environment , and as a result , extremely large number of workers at workplaces where arc welding is performed are exposed to uvr .
this includes not onl... | objectives : ultraviolet radiation ( uvr ) emitted during arc welding frequently causes keratoconjunctivitis and erythema in the workplace .
the degree of hazard from uvr exposure depends on the welding method and conditions .
therefore , it is important to identify the uvr levels present under various conditions .... | pubmed |
a wide variety of taxonomically different groups of microorganisms are known to produce intracellular energy and carbon storage compounds , generally described as polyhydroxyalkanoates ( phas ) .
it has been shown that bacterial cells with a higher content of phas can survive longer than those with a lower phas conte... | the diversity of polyhydroxyalkanoates - producing bacteria in freshwater reservoirs in the ecology glacier foreland , antarctica , was examined by a cultivation - dependent method .
isolated strains were analyzed phylogenetically by 16s rrna gene sequencing , and classified as members of alpha- , beta- , or gammapro... | pubmed |
the operations required to reclaim arid and semi - arid lands fall into several different categories : modifying topography ( slope , contours , and drainage ) , creating appropriate surface composition ( compaction , particle size , and origin of the final surface ) , and establishing vegetation . of these categories ... | of the operations required for reclamation in arid and semi - arid regions , establishing vegetation entails the most uncertainty due to reliance on unpredictable rainfall for seed germination and seedling establishment .
the frequency of successful vegetation establishment was estimated based on a land surface model... | pubmed |
major depression ( md ) is the main cause of disability and the fourth - leading contributor to the global burden of disease . by the year 2020
, md is projected to reach second place in the ranking of disability - adjusted life years .
trials of available antidepressant medications alone or combined with psychothe... | backgroundpatients with treatment - resistant depression ( trd ) who showed partial response to pharmacological and psychotherapeutic interventions need a trial of neuromodulation therapies ( nts).objectivethis paper aims to review evidence - based data on the use of nts in trd.methodusing keywords and combined - word ... | pubmed |
small rna molecules are important in the regulation of various molecular and biological activities in the cell , and it is now well known that short rna sequences play a critical role in regulating the expression levels of specific genes in a targeted manner .
rna interference ( rnai ) has become widely recognized to... | it is now recognized that small noncoding rna sequences have the ability to mediate transcriptional activation of specific target genes in human cells . using bioinformatics analysis and functional screening , we screened short - activating rna ( sarna ) oligonucleotides designed to target the promoter regions of the p... | pubmed |
chronic kidney diseases , which lead to end - stage kidney failure , are associated with changes in kidney structure and fibrosis regardless of the underlying cause .
urinary tract obstruction is characterized by tubular atrophy or dilation , tubular cell death by apoptosis and necrosis , interstitial leukocyte infil... | purposeblockage of the urinary tract induces changes in renal structure including tubular dilatation or atrophy , tubular cell death , inflammatory processes , and progressive interstitial fibrosis with the loss of renal parenchyma .
the present study was conducted to survey the protective effects of taxol and taurin... | pubmed |
pathogen recognition receptors ( prrs ) trigger innate immune responses after sensing microbial components such as lipopolysaccharide ( lps ) , lipoprotein , flagellin , and nucleic acids and are necessary for the protection of a host suffering from microbial infection ( beutler , 2009 ; kawai and akira , 2009 ) . afte... | pattern recognition receptors detect microbial components and induce innate immune responses , the first line of host defense against infectious agents .
however , aberrant activation of immune responses often causes massive inflammation , leading to the development of autoimmune diseases .
therefore , both activat... | pubmed |
the association of this habit with oral cancer was noted over a century ago ; yet the chewing of betel quid in india was considered to be a comparatively innocuous practice with complete socio - cultural acceptance . in recent years it has emerged as a significant public health problem in india
. the normal cultural ... | backgroundbetel nut and betel quid chewing are from major etiological factor for oral cancer .
they also increase the risk of systemic diseases such as asthma , diabetes mellitus , metabolic syndrome , myocardial infarction , hypertension , and other cardiovascular diseases .
methodssixty three patients of oral can... | pubmed |
the concept of patient blood management is gaining increased attention . during the last decade numerous reports have emphasised the need for reductions in transfusions of blood and blood products as allogeneic red blood cell ( rbc ) transfusions are associated with increased morbidity and mortality [ 110 ] , increased... | blood transfusion is associated with increased morbidity and mortality and numerous reports have emphasised the need for reduction . following this
there is increased attention to the concept of patient blood management . however
, bleeding is relatively common following cardiac surgery and is further enhanced by t... | pubmed |
this process requires proliferation , differentiation and migration of neurogenic stem cells into neurons . for many decades
, it was believed that in mammals , neurogenesis occurs only during embryonic life , but a recent work has made it evident that neuronal regeneration occurs even after birth in specific tissues... | objective(s):in the past few decades , variety of foetal , embryonic and adult stem and progenitor cells have been tried with conflicting outcome for cell therapy of central nervous system injury and diseases .
cellular characteristics and functional plasticity of globose basal stem cells ( gbcs ) residing in the olf... | pubmed |
in the past , the central nervous system ( cns ) was considered a site of immune privilege .
microglia , first described by achcarro and subsequently thoroughly characterized by his successor , rio - hortega , are now known to play a pivotal role in innate immunity within the cns .
in addition , emerging evidence d... | microglia play a pivotal role in innate immunity in the brain . during development ,
they mature from myeloerythroid progenitor cells in the yolk sac and colonize the brain to establish a resident population of tissue macrophages . in the postnatal brain , they exert phagocytosis and induce inflammatory response agai... | pubmed |
for a long time , transposable elements ( tes ) have been considered as pure selfish and junk elements parasiting the genome of living organism [ 1 , 2 ] .
these sequences are able to move , that is , to insert into new locations within genomes . this phenomenon is called transposition .
retroelements use retrotr... | due to their ability to drive dna rearrangements and to serve as a source of new coding and regulatory sequences , transposable elements ( tes ) are considered as powerful evolutionary agents within genomes . in this paper , we review the mechanism of molecular domestication , which corresponds to the formation of new ... | pubmed |
these progressive diseases affect increasing number of people ( presently 45 million people world wide , expected to reach 76 millions in 2030 ) .
these devastating diseases have high societal costs and lead , directly or indirectly , to a dramatic loss in life expectancy and quality of life .
these diseases have i... | abstractmisfolded protein aggregates are the hallmark of several neurodegenerative diseases in humans .
the main protein constituent of these aggregates and the regions within the brain that are affected differ from one neurodegenerative disorder to another .
a plethora of reports suggest that distinct diseases hav... | pubmed |
hepatitis c virus ( hcv ) related morbidity and mortality risk is significant in patients with chronic hepatitis c ( chc ) , which affects approximately 3.2 million people in the united states ( 1% of the population).15 in patients treated with interferon ( ifn ) and ribavirin , 2560% achieved sustained virus response ... | background and aims : african americans ( aa ) historically have a low response rate to hepatitis c therapies , and there is limited information available for this patient population regarding the development and treatment of chronic hepatitis c ( chc ) .
the aim of this study was to evaluate liver disease progressio... | pubmed |
stroke is the second common cause of death following ischemic heart disease.1 stroke has accounted for nearly 5.7 million deaths globally and 87% of these deaths take place in low and middle income nations.2 stroke is a multi - factorial disease and epidemiological and animal studies have robustly recommended genetic i... | background and purposethe purpose of this meta - analysis was to determine the precise association between beta-2 adrenergic receptor ( 2ar ) polymorphism and ischemic stroke.methodspublished case control studies on association between 2ar and ischemic stroke were searched from electronic databases . pooled odds ratio ... | pubmed |
methadone ( d , l - methadone hydrochloride ) is frequently used in different therapies including opioid addiction , long - lasting analgesics in cancer and neuropathic pain syndromes [ 13 ] . however , numerous reports indicate a negative impact on human cognition by chronic exposure to opioid drugs .
patients subje... | previously , we have shown that sh - sy5y cells exposed to high concentrations of methadone died due to a necrotic - like cell death mechanism related to delayed calcium deregulation ( dcd ) . in this study , we show that , in terms of their ca2 + responses to 0.5 mm methadone , sh - sy5y cells can be pooled into four... | pubmed |
risk - reducing salpingo - oophorectomy ( rrso)the removal of the fallopian tubes and ovaries to reduce the risks of breast and ovarian cancer is a cancer prevention strategy used by many women who carry germline mutations in the brca1 and/or brca2 genes ( brca1/2 ) .
however , the magnitude of the risk reductions i... | backgroundrisk - reducing salpingo - oophorectomy ( rrso ) is widely used by carriers of brca1 or brca2 ( brca1/2 ) mutations to reduce their risks of breast and ovarian cancer . to guide women and their clinicians in optimizing cancer prevention strategies
, we summarized the magnitude of the risk reductions in wome... | pubmed |
oral lichen planus ( olp ) is a chronic inflammatory disease affecting the oral mucosa , with a prevalence of about 1~2% of the population [ 1 , 2 ] .
once established , the lesions rarely undergo self - remission and , in some cases , have a malignant potency .
histologically , olp is characterized by a dense sube... | interleukin- ( il- ) 23/il-17 axis is a newly discovered proinflammatory signaling pathway and has been implicated in the pathogenesis of many chronic inflammatory and immune disorders .
here we investigated whether the il-23/il-17 axis was present and functional in the lesions of oral lichen planus ( olp ) , a chron... | pubmed |
the isolation of pure populations of cells from heterogeneous cell suspensions is an essential part of clinical as well as basic research .
the diagnostic test for hiv infection , for example , relies on the separation of human lymphocytes from whole blood .
isolation of pure cell populations is an essential part o... | this review describes recent work in cell separation using micro- and nanoscale technologies .
these devices offer several advantages over conventional , macroscale separation systems in terms of sample volumes , low cost , portability , and potential for integration with other analytical techniques . more importantl... | pubmed |
a definitive diagnosis of cirrhosis is made by means of histological findings after liver biopsy . however , taking into consideration the high incidence of virus hepatitis and liver cirrhosis , a significant number of patients undergo imaging examinations before the definitive diagnosis of cirrhosis has been establish... | background & aims the purpose of the study is to evaluate the accuracy of the c / rl , rpn , and egf in diagnosing cirrhosis .
methods the study population included 95 cirrhotic patients in the cirrhosis group ( 56 men , 39 women , age range 14 - 76;mean age 52.3 ) and 57 subjects in the control group ( 26 men , 31 w... | pubmed |
participants from this study were included in a prospective longitudinal study designed to evaluate optic nerve structure and visual function in glaucoma ( the diagnostic innovations in glaucoma study ) conducted at the hamilton glaucoma center at the department of ophthalmology , university of california , san diego (... | purposethe purpose of this study was to evaluate the effect of disease severity and number of tests acquired during follow - up on the relative odds of identifying progression by structural or functional tests in glaucoma.methodsthis was an observational cohort study involving 462 eyes of 305 patients with glaucoma and... | pubmed |
as has been the case in most other industries , the promise of new technologies and innovations has been cited as the way to address the healthcare industry s current challenges ; in particular , to circumvent the so - called iron triangle
, simultaneously improving access , cost , and quality of care . at the same ... | academic investigators are generating a plethora of insights and technologies that have the potential to significantly improve patient care . however , to address the imperative to improve the quality , cost and access to care with ever more constrained funding , the efficiency and the consistency with which they are t... | pubmed |
bladder cancer is the second most common cancer in the urogenital tract . in about 85% of cases at the time of diagnosis of cancer
is limited only to the urinary bladder in the remaining 15% of the observed expansion beyond the urinary bladder .
the first confirmed carcinogenic factors were the aromatic amines : o ... | an analysis of the reliability of a questionnaire on smoking in 96 patients with transitional cell carcinoma ( tcc ) of the bladder .
the credibility of the questionnaire was evaluated based on the detection of cotinine , an objective marker of tobacco smoke exposure , in urine .
it was confirmed that approximately... | pubmed |
anal incontinence is a bothersome ailment associated with many health complaints and discomfort in daily life : hygienic problems , limitations in occupational and social life , sexual dysfunction , reduced quality of life , and altered self - esteem .
prevalence and severity of anal incontinence are measured by pati... | the aim of this study was to assess the prevalence and risk factors of anal incontinence in an unselected pregnant population at second trimester .
a survey of pregnant women attending a routine ultrasound examination was conducted in a university hospital in oslo , norway . a questionnaire consisting of 105 items co... | pubmed |
the incidence of hypotension in non - obstetric patients ranges between 5% and 66% , depending on the definition of hypotension limit , timing of measurements , and differences between data acquisition methods and patient characteristics .
previous cohort studies reported that hypotension due to spinal anesthesia was... | backgroundhypotension is the most common problem with spinal anesthesia .
this prospective study aimed to compare normotensive and hypertensive patients with respect to the hemodynamic effects of spinal anesthesia performed with hyperbaric bupivacaine.material/methodssixty patients who were scheduled to undergo vario... | pubmed |
chronic pain and depression are among the most common health problems reported by patients attending primary care [ 13 ] . diagnosing pain and its coexistence with depression and getting an overview of the pain patient 's situation can be challenging and can have great consequences for the treatment outcome .
numerou... | background . coexistence of pain and depression has significant impact on the patient 's quality of life and treatment outcome .
dolotest is a pain and hrqol assessment tool developed to provide shared understanding between the clinician and the patient of the condition by a visual profile . aim . to find the sensiti... | pubmed |
human papillomavirus ( hpv ) is a non - enveloped deoxyribonucleic acid ( dna ) virus belonging to the family papillomaviridae .
this family includes more than 130 genotypes,1 many of which infect the mucosal areas of the human upper digestive tract and the anogenital region through sexual contact,2,3 leading to incr... | backgroundhuman papillomavirus ( hpv ) is the cause of 90%95% of squamous cell cancers .
persistent infection with high - risk hpv can lead to development of precancerous lesions of the cervix in 5%10% of infected women , and can progress to invasive cervical cancer 1520 years later .
this study was conducted to de... | pubmed |
today s world witnesses rapid innovations and developments in the area of health care ( 1 ) , so that medical knowledge has expanded rapidly over the past fifty years ( 2 ) and the number of scientific papers published has doubled over 10 years ( 3 ) . on the other hand , studies indicate that in the patient s beside ,... | background : regarding the role and importance of paradigm of evidence based practice and its remarkable impact on the effectiveness and efficiency of clinical services and healthcare , development of an integrated system seems necessary in order to manage dispersed data and ensure using evidence in clinical decision m... | pubmed |
human metapneumovirus ( hmpv ) is a negative single - stranded rna virus of the family paramyxoviridae and closely related to the avian metapneumovirus ( ampv ) subgroup c [ 1 , 2 ] .
hmpv is an important aetiological agent of respiratory tract infection ( rti ) in infants , or senior and immunocompromised individual... | human metapneumovirus ( hmpv ) is an important agent of acute respiratory tract infection in children , while its pathogenicity and molecular evolution are lacking . herein , we firstly report the synonymous codon usage patterns of hmpv genome .
the relative synonymous codon usage ( rscu ) values , effective number o... | pubmed |
as more and more genomes are automatically sequenced , comprehensive protein annotation is a needed step after gene identification . even in good annotated genomes ( human , mouse ) about 30% of all proteins are not functionally identified ( 13 ) , and thus often a similarity search will not be sufficient . here , we p... | the wealth of transcript information that has been made publicly available in recent years has led to large pools of individual web sites offering access to bioinformatics software . however , finding out which services exist , what they can or can not do , how to use them and how to feed results from one service to th... | pubmed |
delirium is a common and severe complication among elderly patients and is associated with increased morbidity and mortality , prolonged hospital stay , increased risk of post - discharge institutionalization and dementia .
identifying accurate biomarkers for delirium may shed light on the pathophysiology and may hel... | backgroundoxidative stress and disturbances in serotonergic and dopaminergic neurotransmission may play a role in the pathophysiology of delirium.aimsin this study , we investigated levels of amino acids , amino acid ratios and levels of homovanillic acid ( hva ) as indicators for oxidative stress and disturbances in n... | pubmed |
overweight and obesity prevalence rates are increasing worldwide . about 1.4 billon adults were overweight in 2008 , of whom 200 million men and 300 million women were considered to be obese . in the netherlands , prevalence rates of overweight ( and obesity ) are 60% ( 14% ) in men and 44% ( 13% ) in women .
high pr... | background .
active modes of transport like walking and cycling have been shown to be valuable contributions to daily physical activity . the current study investigates associations between personal and neighbourhood environmental characteristics and active transport among inhabitants of dutch deprived districts
. ... | pubmed |
optic neuritis related to ms is an acute optic neuropathy occurring in young people , especially in women .
the clinical picture shows a decline in visual acuity , a pain which increases with movements of the eye , a decline in contrast sensitivity , dyschromatopsia and changes in the visual field ( 1 ) .
it occurs... | aim : to analyze the clinical signs of multiple sclerosis ( ms ) and show that optic neuritis is one of the first event , which indicates the development of disease.patients and methods : the study involved 89 cases in which it confirmed ms at the time of the march 20092011 . since ophthalmological parameters were anal... | pubmed |
diabetes can cause acute and long - term complications , and is as well , a global risk factor for cardiovascular disease.1 lifestyle and behavior , as well as individual genetic predisposition , influence the risk of diabetes and prevalence in a community.2 public knowledge is the basis for lifestyle and behavior in a... | background and purposethe public knowledge of diabetes is important for prevention of disease . this study aimed to evaluate knowledge of diabetes , risk factors , and the common warning signs of diabetes and complications among community participants in a rural karen ethnic community.methodsparticipants
were asked t... | pubmed |
it is well established that individuals with serious mental illness ( smi ) , which include diagnoses like schizophrenia and bipolar disorder , have a much higher rate of morbidity and mortality in comparison to the general population .
specifically , diabetes impacts approximately 25% of individuals with smi , 2 to ... | objective : individuals with serious mental illness ( smi ) have higher rates of preventable diseases such as diabetes in comparison to the general population .
while multifaceted , these high rates of preventable diseases in the population with smi may be partially attributed to limited access to primary care . a ne... | pubmed |
the american demographer and sociologist valerie oppenheimer wrote a series of influential articles in which she emphasized the role of men s socioeconomic position in demographic change , in particular in the declining rates of marriage and the underlying tendency to increasingly postpone and perhaps even forego marri... | this article discusses oppenheimer s theory on marriage timing , reviews the way this theory was received in european demography and family sociology , and develops a new test of the theory using annual panel data from 13 european countries for the period 19942001 .
several indicators of men s economic status are use... | pubmed |
osteoporosis is a condition of impaired bone strength which leads to increased risk of fracture .
the enhanced bone fragility reflects the integration of the amount of bone ( bone mass ) and bone quality .
bone quality depends on its macro- and microarchitecture and on the intrinsic properties of the materials that... | multiple sclerosis ( ms ) is a gait disorder characterized by acute episodes of neurological defects leading to progressive disability .
patients with ms have multiple risk factors for osteoporotic fractures , such as progressive immobilization , long - term glucocorticoids ( gcs ) treatment or vitamin d deficiency .... | pubmed |
malaria is one of the main scourges of the world , affecting half a million people a year .
it is caused by parasites belonging to the phylum apicomplexa , family plasmodiidae , and genus plasmodium .
there are five known species that parasitize man , the most prevalent being plasmodium falciparum , p. vivax , and ... | side effects of antimalarial drug can overlap with malaria symptoms .
we evaluated 50 patients with vivax malaria in mncio lima , acre , treated with chloroquine and primaquine .
patients were evaluated for the presence of 21 symptoms before and after treatment and for reported side effects of these drugs after tre... | pubmed |
from a worldwide perspective , the life span of humans has been prolonged , and the proportion of elderly people in the total population has increased .
various changes occur in the human body with age . in elderly men , lower urinary tract symptoms ( luts ) , erectile dysfunction ( ed ) , and decreased libido often ... | purposeto examine the effects on erectile function of concomitant treatment with an alpha - blocker ( tamsulosin ) and an antimuscarinic agent ( solifenacin ) in patients with lower urinary tract symptoms ( luts)/benign prostatic hyperplasia ( bph).materials and methodsfifty - seven male patients with luts / bph were a... | pubmed |
specific mirnas have been found to be expressed in cell type - specific manner , at specific developmental stages , and in disease states including cancer [ 1 , 2 ] . during the initiation and progression of cancer , mirnas
have been observed to act as oncogenes or tumor suppressors [ 3 , 4 ] .
while some mirnas ar... | we focus on unique roles of mir-200c in breast , ovarian , and endometrial cancers
. members of the mir-200 family target zeb1 , a transcription factor which represses e - cadherin and other genes involved in polarity .
we demonstrate that the double negative feedback loop between mir-200c and zeb1 is functional in... | pubmed |
the transobturator approach to treat female stress urinary incontinence by means of a midurethral sling ( mus ) placement was first described by delorme to potentially prevent complications associated with the retropubic mus placement originally described by ulmsten ( delorme , 2001 ; ulmsten et al . , 1996 ) .
a sim... | the three - dimensional configuration of mid - urethral sling tapes is difficult to demonstrate in traditional anatomical dissections or imaging studies . the aim of this study was to test the utility of a novel technique using mesh tapes to assess spatial differences between the in - out and out - in transobturator mi... | pubmed |
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