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over the past decade , protein separation techniques and peptide analysis by mass spectrometry have greatly improved , and qualitative and quantitative proteome comparisons have become powerful tools for defining the composition of complex proteomes and the functions of protein complexes.(1 ) current ion trap mass spec... | in - depth , reproducible coverage of complex proteomes is challenging because the complexity of tryptic digests subjected to lc - ms / ms analysis frequently exceeds mass spectrometer analytical capacity , which results in undersampling of data . in this study
, we used cancer cell lysates to systematically compare ... | pubmed |
although perioperative mortality from tonsillectomy and submucosal uvulopalatopharyngoplasty ( smuppp ) with tonsillectomy has decreased significantly , postoperative bleeding is still an important complication .
the incidence of bleeding after tonsillectomy is approximately 0.5%-10% , with death occurring in 1 in 20... | background : the aim of this study was to compare the incidence of postoperative secondary hemorrhage for tonsillectomy and submucosal uvulopalatopharyngoplasty ( smuppp).materials and methods : in this retrospective case series , the medical records of 404 patients who underwent tonsillectomy with unipolar electrocaut... | pubmed |
the - and -lactam
scaffolds are found in various
biologically relevant compounds . additionally , these core structures
are crucial intermediates in the synthesis of various natural products
as well as pharmaceuticals , prompting the development of new methods
for the synthesis of these valuable structures . ... | sulfone - substituted
- and -lactams have been prepared
in a single step with high diastereoselectivity .
sulfonylglutaric
anhydrides produce intermediates that readily decarboxylate to provide
-lactams with high diastereoselectivity .
substituents at the
3- or 4-position of the glutaric anhydride induce ... | pubmed |
the morbidity of breast cancer is gradually increasing , and a growing number of young people are now at risk for this disease . in china ,
breast cancer continues to be the leading cause of death among women . with the improvement in diagnosis and development of drugs and radiotherapy technology
. therefore , earl... | backgroundthis study aimed to investigate the expression and significance of 5 types of mirnas in breast cancer to provide a theoretical and practical foundation for using these mirnas in the diagnosis and treatment of breast cancer , thereby improving medical services.material/methodsstem-loop real - time rt - pcr was... | pubmed |
however , transplantation is limited not only by organ shortage but also by its unfavorable long - term success due to chronic allograft injury ( cai ) [ 1 , 2 ] . chronic allograft vasculopathy ( cav ) , glomerulosclerosis , and interstitial fibrosis and tubular atrophy ( ifta ) are the dominating histopathological fi... | acute rejection is a major risk factor for chronic allograft injury ( cai ) .
blood leukocytes interacting with allograft endothelial cells during acute rejection were suggested to contribute to the still enigmatic pathogenesis of cai .
we hypothesize that tissue transglutaminase ( tgm2 ) , a multifunctional protei... | pubmed |
endothelial cells ( huvec passage 46 ; clonetics , walkersville , md ) were grown to confluence , then stimulated with plasminogen activation inhibitor-1 ( pai-1 , 10 ng / ml ; american diagnostica inc . ,
supernatant was collected 3 hours after stimulation and centrifuged ( 145 g , 8 minutes ) to remove cell debris ... | backgroundendothelium - derived microparticles ( emps ) are submicron vesicles released from the plasma membrane of endothelial cells in response to injury , apoptosis or activation .
we have previously demonstrated emp - induced acute lung injury ( ali ) in animal models and endothelial barrier dysfunction in vitro ... | pubmed |
patients with frequent angina ( 1 episode per week ) report greater physical limitations and decreased quality of life compared with patients with minimal angina.1 the goals of chronic stable angina management are not only to control symptoms , but also to reduce the risk of adverse clinical outcomes.26 as symptom cont... | backgroundsublingual nitroglycerin increases exercise duration in patients with stable angina .
brief results from this study were published previously in german . here , we more fully describe the study methodology , patient characteristics , and detailed results.methodsthis double - blind , crossover study enrolled... | pubmed |
the residual and resistant microorganisms have been recognized as the basic reason for failures in root canal treatments .
fungi , chemoorganotrophic eukaryotic microorganisms , may play a key part in periradicular diseases . while they have been found sporadically in initial root canal infections ,
failure of some... | background : fungi may play a key part in periradicular diseases . the aim of this study was to evaluate and compare the antifungal properties of two root - end filling materials , proroot mineral trioxide aggregate ( mta ) and mta - angelus , against candida albicans using tube - dilution test.materials and methods : ... | pubmed |
deficits of motor and sensory functions after stroke on the side contralateral to the
damaged hemisphere are often evident1 ,
whereas the ipsilateral side may be primarily regarded as normal or unaffected . however ,
there is increasing evidence of the presence of subtle motor deficits in motor performance
on t... | [ purpose ] previous studies have reported on motor deficits in the ipsilateral upper
limbs ( ul ) of a damaged brain hemisphere in motor tasks . however , little is known about
sensory deficits on the ipsilateral side .
therefore , we investigated whether both motor
and sensory function of the ipsilateral ul a... | pubmed |
the specific targeting of nanoparticles to target cells in an organ of interest has been a long - term goal of many laboratories interested in using nanoparticles to mediate the functional delivery of biopharmaceutical agents ( including nucleic acids ) to defined target cells .
one of the main problems in using targ... | a key goal of our research is the targeted delivery of functional biopharmaceutical agents of interest , such as small interfering rna ( sirna ) , to selected cells by means of receptor - mediated nanoparticle technologies .
recently , we described how ph - triggered , pegylated sirna - nanoparticles ( ph triggered s... | pubmed |
the millennium cohort is the largest prospective study using primary data collection ever undertaken by the department of defense ( dod ) .
the study began in 2001 with the objective to collect and evaluate data on health , behavioral risk factors , and occupational characteristics related to military service that ma... | objectiveresearch has suggested that a higher risk of type 2 diabetes associated with sleep characteristics exists .
however , studies have not thoroughly assessed the potential confounding effects of mental health conditions associated with alterations in sleep.research design and methodswe prospectively assessed th... | pubmed |
we retrospectively reviewed the radiological and clinical findings of 13 patients with a pathologically confirmed mesenchymal hamartoma of the liver .
the institutional review board approved the review of the radiological and clinical data for this study and waived the requirement for informed consent .
a computed ... | objectivea hepatic mesenchymal hamartoma is an uncommon benign tumor in children and little is known about the spectrum of its radiological features .
the purpose of this study is to describe the spectrum of radiological features of a hepatic mesenchymal hamartoma in children.materials and methodsthirteen children wi... | pubmed |
rheumatoid arthritis ( ra ) is a disabling and progressive chronic autoimmune disease that carries a significant burden.1 although ra affects people of all ages , its prevalence increases with increasing age and it is more common in women than in men.2,3 a prevalence of 0.5%1% and a mean annual incidence ( ie , rate of... | this literature review examines available evidence on the current and past costs associated with rheumatoid arthritis ( ra ) in italy , together with the future health - economic prospects for the disease .
studies have been conducted to date on the prevalence , or the associated costs , of ra in italy .
although f... | pubmed |
in prosthodontic practice , limited mouth opening in patients is a common occurrence . prosthetic rehabilitation of patient with restricted mouth opening due to any causative factors , presents difficulties at all stages , right from the preliminary impressions to the insertion of prosthesis . a maximal oral opening sm... | restricted mouth opening is a definite prosthodontic hindrance to carry out treatment successfully .
restricted mouth opening can be due to many reasons such as microstomia , oral submucous fibrosis , some genetic disorder , and as a result of some surgical treatment . in the past ,
various techniques for prostheti... | pubmed |
hepatocellular carcinoma ( hcc ) is the sixth most common malignancy worldwide and the third most common cause of global cancer related mortality [ 1 , 2 ] .
hcc burden disproportionately impacts developing countries and males ; as of 2008 , 85% of cases occurred in africa and asia , with worldwide male : female sex ... | under normal physiological conditions , the hepatocyte growth factor ( hgf ) and its receptor , the met transmembrane tyrosine kinase ( cmet ) , are involved in embryogenesis , morphogenesis , and wound healing .
the hgf - cmet axis promotes cell survival , proliferation , migration , and invasion via modulation of e... | pubmed |
the associations between diabetes and cancer have been the subject of debate for over a century .
the length of this debate suggests , perhaps , that any such associations are relatively weak , and it is safe to say that most practicing diabetologists do not view cancer as a specific , diabetes - associated risk in d... | diabetes , in particular type 2 , is associated with an increased incidence of cancer .
although the mortality attributable to cancer in type 2 diabetes is overshadowed by that due to cardiovascular disease , emerging data from epidemiologic studies suggest that insulin therapy may confer added risk for cancer , perh... | pubmed |
adamantinoma of the tibia is a rare slow - growing primary tumor of the bone .
there has been much controversy on the origins of this tumor with one major focus being the relationship between osteofibrous / fibrous dysplasia and adamantinoma .
there have been approximately 300 cases of tibial adamantinoma reported ... | adamantinoma is a rare primary bone tumor that commonly arises in the jaw and has also been described in the appendicular skeleton such as the tibia .
we report 2 cases of tibial adamantinomas that were originally misdiagnosed ; one as fibrous dysplasia of the tibia and the other as a cutaneous eccrine carcinoma in a... | pubmed |
antireflection ( ar ) technology plays an important role in the fabrication of high - efficiency solar cells by increasing light coupling into the active region of devices .
generally , a relatively low - light reflectivity can be obtained for crystalline silicon solar cells by combining surface texturization with si... | an efficient antireflection coating is critical for the improvement of silicon solar cell performance via increased light coupling . here
, we have grown well - aligned zno nanowhisker ( nw ) arrays on czochralski silicon solar cells by a seeding - growth two - step process . it is found that the zno nws have a great... | pubmed |
little is understood about this condition 's mechanism , exacerbating factor , and definite treatment .
hyperhidrosis generally occurs in the axillae , the palms , plantar surface of the feet , and the face .
it is estimated to affect 0.6 to 1.0% of the population , generally young adults .
the principal characte... | backgroundvideo - assisted thoracic sympathicotomy plays an important for the treatment of essential hyperhidrosis .
patients are usually satisfied with the surgical outcome at the early post - operative period , but suffer recurrence and compensatory sweating in the late post - operative period .
there are many sy... | pubmed |
parkinson disease ( pd ) , which is the most common neurodegenerative parkinsonian syndrome , is characterized by the degeneration of both dopaminergic and nondopaminergic neurons with neuronal intracytoplasmic inclusions known as lewy bodies 1 .
although the clinical diagnosis of pd is often straightforward and robu... | objectivemolecular imaging of nigrostriatal dopamine transporters ( dat ) and sympathetic cardiac innervation with single - photon emission computed tomography ( spect ) are useful tools for differentiating idiopathic parkinson disease ( pd ) from other degenerative parkinsonian syndromes ( non - pd ) . nevertheless , ... | pubmed |
the ticks that belong to the genus amblyomma are large , ornate , longirostrate blood - feeding ectoparasites of a wide variety of vertebrates .
amblyomma testudinarium is one of the species that has been frequently reported to bite humans in asian countries .
usually , only a few ticks attached to and fed on a hum... | a perianal tick and the surrounding skin were surgically excised from a 73-year - old man residing in a southwestern costal area of the korean peninsula .
microscopically a deep penetrating lesion was formed beneath the attachment site .
dense and mixed inflammatory cell infiltrations occurred in the dermis and sub... | pubmed |
hypertrophic cardiomyopathy ( hcm ) is characterized by left and/or right ventricular hypertrophy , with predominant involvement of the interventricular septum in the absence of other causes of hypertrophy , such as hypertension , valvular heart disease , or metabolic disease [ 17 ] .
familial hcm is an autosomal dom... | hypertrophic cardiomyopathy ( hcm ) is an autosomal dominant disorder resulting from mutations in genes for at least 15 various sarcomere - related proteins including cardiac -myosin heavy chain , cardiac myosin - binding protein c , and cardiac troponin t. the troponin t gene ( tnnt2 ) mutation has the third incidence... | pubmed |
schistosomatidae ( platyhelminthes : digenea ) includes several digenetic endoparasites with complex life cycles , whose developmental stages alternate between intermediate ( freshwater gastropods ) and definitive hosts ( birds , reptiles , fishes , and mammals ) .
another important feature is the increased longevity... | schistosomes are digenean blood flukes of aves and mammals comprising 23 species .
some species are causative agents of human schistosomiasis , the second major neglected disease affecting over 230 million people worldwide .
modern technologies including the sequencing and characterization of nucleic acids and prot... | pubmed |
for patients with synchronous colorectal liver metastases ( sclm ) , hepatic resection is considered the best treatment , with reported 5-year survival rates between 23% and 37%.14 resections of both the primary colorectal lesion and the hepatic metastases are needed for patients with sclm when they are resectable .
... | backgroundthe optimal surgical strategy for resectable , synchronous , colorectal liver metastases remains unclear .
the objective of this study was to determine which patients could benefit from staged resections instead of simultaneous resection by identifying predictive factors for postoperative morbidity and anas... | pubmed |
asthma is a chronic inflammatory disease that causes airflow limitation and affects the performance of activities of daily living.1 pharmacological treatment is essential2 and is aimed at achieving and maintaining clinical asthma control.1 inhalation is the most widely used approach for the treatment of asthma because ... | abstractobjective : to validate two scores quantifying the ability of patients to use metered dose inhalers ( mdis ) or dry powder inhalers ( dpis ) ; to identify the most common errors made during their use ; and to identify the patients in need of an educational program for the use of these devices .
methods : this... | pubmed |
bacteriocins are ribosomally synthesized antimicrobial peptides produced by bacteria that deserve considerable interest for their use as natural and nontoxic food preservatives as well as for their potential use in human and veterinary applications , and in the animal production field . in 1976
tagg et al . defined b... | the aim of this research was to purify and characterize the mode of action of enterocin s37 , a bacteriocin produced by enterococcus faecalis s37 , a strain recently isolated from the chicken feces .
enterocin s37 has a molecular weight comprised between 4 and 5 kda .
it remained active after 1 h at 80oc and at p... | pubmed |
these trials were conducted in compliance with the declaration of helsinki , the international conference on harmonisation good clinical practice guidelines , the european union clinical trials directive , and local regulatory requirements .
approval for the study protocols and all amendments were obtained from colum... | nusinersen ( isis - smnrx or isis 396443 ) is an antisense oligonucleotide drug administered intrathecally to treat spinal muscular atrophy .
we summarize lumbar puncture experience in children with spinal muscular atrophy during a phase 1 open - label study of nusinersen and its extension . during the studies ,
73... | pubmed |
the main concern is to ensure the highest possible standard for the services provided and to meet the needs of individual service users and communities ( 1 ) . in 1997 ,
the uk department of health introduced clinical governance ( cg ) as a strategy for improving quality of health care services ( 2 ) .
the classic ... | abstractbackgroundhealth care systems should assign quality improvement as their main mission . clinical governance ( cg )
is a key strategy to improve quality of health care services .
the iranian ministry of health and medical education ( mohme ) has promoted cg as a framework for safeguarding quality and safety ... | pubmed |
hydatid cyst disease is one of the most important zoonotic diseases , which occur , in larval stage of echinococcus granulosus parasite . in this disease ,
canines such as dog , wolf , fox , and jackal ( the final host ) are infected by eating contaminated viscera , and small adult worms with size of 27 mm are formed... | background : this study aimed to investigate the epidemiological and clinical aspects of patients with hydatid cyst during 2011 to 2014.methods:this cross - sectional study was conducted in khorasan razavi province , the northeast of iran , from 2011 to 2014 .
the study population was all cases with hydatid cyst who ... | pubmed |
friederich is credited with describing the first case of a ciliated hepatic foregut cyst ( chfc ) in 1857 and positing their congenital origin .
wheeler and edmonson were the first to use the term chfc to describe the lesion .
they also identified specific characteristics , which differentiate it from other hepat... | ciliated hepatic foregut cysts ( chfcs ) are rare congenital cysts of the liver that originate from the embryologic foregut .
despite an increase in incidence , they remain rare and several key characteristics remain poorly understood , including the range of presentation and the risk of malignant conversion .
larg... | pubmed |
oral route is one of the most preferred routes of drug administration due to its safety , ease of administration , and acceptability by patients .
about 60% of conventional dosage forms are available as the oral solid dosage forms . the low bioavailability , longer onset of action , and dysphasia patients turned the ... | clobazam orally dissolving strips were prepared by solvent casting method .
a full 32 factorial design was applied for optimization using different concentration of film forming polymer and disintegrating agent as independent variable and disintegration time , % cumulative drug release , and tensile strength as depen... | pubmed |
stroke is a major cause of death and disability world - wide . by 2020 stroke , together with coronary - artery disease ,
stroke represents an often devastating disruption to life , the majority of survivors experiencing some degree of impairment requiring additional care or support 1 year post - stroke .
stroke is... | purposeto systematically review the psychometric properties of outcome measures used in stroke self - management interventions ( smis ) to ( 1 ) inform researchers , clinicians and commissioners about the properties of the measures in use and ( 2 ) make recommendations for the future development of self - management me... | pubmed |
osteoarthritis ( oa ) in knee joint is the most common reason behind functional disability that leads to lowered quality of life in old age people of india .
some of the objective factors that may influence oa disease severity include but are not limited to age , height , weight , and bmi . in physiotherapy practice ... | purpose . objective of the present study was to see the correlation of subjectively measured koos questionnaire with objectively measured 6-minute walk test ( 6-mwt ) , age , height , weight , and bmi .
participants .
251 subjects with oa knee based on american college of rheumatology criteria . methods . after pas... | pubmed |
an increasingly sedentary lifestyle combined with rising consumption of caloric foods has transformed obesity into a global event .
obesity is a low - level , chronic inflammatory disease with a multifactorial etiology that includes eating habits , a sedentary lifestyle , and genetic predisposition that promotes the ... | four - week - old female wistar rats were divided into two groups and fed a control diet ( c ) or a hyperlipidic diet ( h ) for 4 weeks .
rats from each group underwent ovariectomy ( ovx ) or sham surgery ( sham ) .
they received c or h for the next four weeks . the body weight gain ( bw ) , food efficiency ( fe ) ... | pubmed |
hemoptysis is one of the most common symptoms in patients with respiratory diseases , when massive , has a mortality rate of more than 50%
. therefore , significant or life - threatening hemoptysis calls for quick treatment to stop bleeding . in the past
, the control of hemoptysis had been obtained using surgical ... | background : hemoptysis is a significant clinical entity with high morbidity and potential mortality .
both medical management ( in terms of resuscitation and bronchoscopic interventions ) and surgery have severe limitations in these patients population .
bronchial artery embolization ( bae ) represents the first -... | pubmed |
helicobacter pylori ( hp )
infection may cause several clinical manifestations , ranging from asymptomatic
to significant gastroduodenal disease including ulcer , bleeding , perforation ,
and adenocarcinoma . no pathogenic mechanism is known to explain the above
diversity .
celiac disease ( cd ) is a
t - ce... | lymphocytic gastritis ( lg ) is associated with helicobacter pylori ( hp ) and celiac disease ( cd ) .
we aimed to clarify
the relationship between hp infection and cd by defining a unique histopathology profile of lg in these two diseases .
forty patients who underwent upper endoscopy were divided into four ... | pubmed |
angiogenesis , the process by which the existing vascular network expands to form new blood vessels , is required for the growth of solid tumors . for this reason ,
vascular endothelial growth factor ( vegf ) , a primary stimulant of angiogenesis , binds and activates vegf receptor 1 ( vegfr1 ) and vegfr2 . vegf is a... | cancer is the second leading cause of death in the world after cardiovascular diseases .
some types of cancer cells often travel to other parts of the body through blood circulation or lymph vessels , where they begin to grow .
this process is recognized as metastasis .
angiogenesis is the formation of new blood ... | pubmed |
vulvar and vaginal atrophy ( vva ) , resulting from the loss of estrogen stimulation on vaginal and vulvar tissue , is a common medical condition in postmenopausal women
one that will occur in most postmenopausal women at some point in their lives.1,2 there are an estimated 64 million postmenopausal women in the unit... | vulvar and vaginal atrophy ( vva ) is a chronic and progressive medical condition common in postmenopausal women
. symptoms of vva such as dyspareunia , vaginal dryness , irritation , and itching can negatively impact sexual function and quality of life .
the revive ( real women s views of treatment options for men... | pubmed |
in denmark , women planning to conceive are advised to take a daily supplement of 400 g folic acid ( fa ) until the 12th week of gestation to reduce the risk of neural tube defects ( ntds).1 starting fa supplementation before conception is an important component of effective prevention of ntds , since the neural tube c... | purposecompliance with the danish preconceptional folic acid ( fa ) recommendation a daily supplement of 400 g is reported to be poor .
uncertainty remains , however , about the prevalence of compliers and health - related predictors of compliance in the preconceptional period.methodswe used self - reported baselin... | pubmed |
peripheral arterial disease ( pad ) commonly results from progressive narrowing of arteries in the lower extremities due to atherosclerosis .
it has become evident that pad is an important predictor of substantial coronary and cerebral vascular risk [ 2 , 3 ] .
the most common symptomatic manifestation of mild to m... | the various risk factors for peripheral arterial disease ( pad ) are almost identical to those for atherosclerosis and include abnormal levels of lipids or lipoproteins . lipid peroxidation parameters and total antioxidant capacity in the serum of male patients with pad before surgery as well as
35 days and 710 days ... | pubmed |
in recent years , the demand for herbal remedies in nigeria has been on the rise .
yet there are little or no scientific data to support medicinal claims of these herbal formulations .
herbals are usually sought after for their health benefits and these have become common medicines in many nigerian homes .
it is ... | this study determined the effect of the oral and repeated administration of fijk herbal mixture on rat biochemical and morphological parameters .
twenty - four wistar rats were distributed into four groups of 6 .
group a served as control and received oral administration of distilled water daily .
the experimenta... | pubmed |
identifying carriers of autosomal recessive or x - linked disorders before pregnancy has the potential to benefit prospective parents .
couples can become aware of the possible genetic risks to future offspring and of the reproductive options available .
these options include not only prenatal diagnosis followed ( ... | recently , a number of commercial companies are offering preconceptional carrier tests directly - to - consumers .
this offer raises a number of concerns and issues above and beyond those encountered with preconceptional tests offered within the traditional health care setting . in order to bring some of these issues... | pubmed |
substantial growth has occurred in the options for operative fracture treatment in the last few decades.1 this , in proportion to newer and better internal fixation devices or implants .
specially designed intramedullary ( i m ) nails , and plates and screws for every bone and even parts of bones have helped increase... | introduction : fracture fixation has become advanced with the advent of new and custom metal implants for each type of bone / fracture . after union
though , the implant ceases to be important and may be removed .
routine removal is advocated by some and opposed by others .
nevertheless , some patients require re... | pubmed |
glaucoma , a neurodegenerative disease , is characterized by gradual loss of retinal ganglion cells ( rgcs ) and optic nerve atrophy.1 multiple factors are related to glaucoma , such as high intraocular pressure ( iop)2 and low cerebral spinal fluid pressure.3 mller cells are the major type of glial cells in the mammal... | objectiveocular hypertension is an important risk factor for glaucoma .
the purpose of this study was to investigate the gliotoxic effects of -aminoadipic acid ( aaa ) in a rat model of aoh and its underlying mechanisms.materials and methodsin the rat model of acute ocular hypertension ( aoh ) , intraocular pressure ... | pubmed |
although endoscopic resection can be a curative procedure for such lesions 1 , it still remains technically challenging because of the high risk of severe adverse events ( saes ) including delayed perforation 2 . on the other hand , surgical treatment of such lesions often results in extensive resections , causing sign... | background and study aims : recently , laparoscopic and/or endoscopic full - thickness resection ( ftr ) has been reported to be a useful technique for the treatment of superficial duodenal neoplasms ( sdns ) . in the current study , we evaluated clinical outcomes in 5 consecutive patients who underwent resection of no... | pubmed |
congenital adrenal hyperplasia ( cah ) is caused by defects in various enzymes necessary for cortisol synthesis .
90 - 95% of cah cases are caused by 21-hydroxylase deficiency ( 21-ohd ) . in patients with 21-ohd ,
some of these precursors are shunted into the androgen synthetic pathway , causing signs and symptoms... | congenital adrenal hyperplasia ( cah ) caused by 21-hydroxylase deficiency is an autosomal recessive disease , which leads to cortisol and aldosterone deficiency and hyperandrogenism .
typical medical treatment includes oral glucocorticoid and mineralocorticoid administration to suppress adrenal androgens and to comp... | pubmed |
self - evaluation of general health status has been associated with actual health in that what people report about their health has been shown to predict mortality .
self - rated health ( srh ) as a single survey question developed by the world health organization ( who ) has been validated as a tool to predict mor... | background . lack of adherence to dietary and physical activity guidelines has been linked to an increase in chronic diseases in the united states ( us ) .
the aim of this study was to assess the association of lifestyle behaviors with self - rated health ( srh ) .
methods .
this cross - sectional study used self... | pubmed |
the role of endoscopic injection of dextranomer / hyaluronic acid copolymer ( dx / ha ) has expanded , as an alternative to open surgery , to a treatment option for observation protocols using prophylactic antibiotics .
deflux has been fda approved since 2001 as a treatment option for grade 24 vesicoureteral reflux (... | the endoscopic injection of dx / ha in the management of vesicoureteral reflux ( vur ) has become an accepted alternative to open surgery . in the current study we evaluated the value of cystography to detect de novo contralateral vur in unilateral cases of vur at the time of dx / ha injection and correlated the findin... | pubmed |
the accuracy to detect fetal pathology depends on the expertise of the sonographer and some limitations inherent to this imaging technique .
descent of the fetal head and progressive ossification of the skull bones towards the end of the pregnancy , maternal obesity and oligohydramnios are all well - known limitation... | the indication for fetal magnetic resonance imaging ( mri ) remains a subject of debate , partly because of questions concerning its diagnostic accuracy compared to ultrasound , partly because of practical factors such as accessibility , high costs and available expertise .
most studies advocate an added value for mr... | pubmed |
lung cancer is the third most common cancer diagnosed and the most common cause of cancer - related death among both men and women in the united states ( us ) .
the american cancer society estimates that in 2012 , 226,160 patients ( men , 116,470 ; women , 109,690 ) will be diagnosed with lung cancer and 160,340 ( me... | background : to quantify the impact of bone metastasis and skeletal - related events ( sres ) on mortality among older patients with lung cancer.materials and methods : using the linked surveillance , epidemiology and end results - medicare database , we identified patients aged 65 years or older diagnosed with lung ca... | pubmed |
fiber - reinforced posts have superior advantages as compared with cast posts , generally regarding their esthetics , physical properties and their modulus of elasticity , which is similar to root dentin.1 posts are generally cemented with resin cements . proper selection of resin cements influence the retention of pos... | purposethe purpose of this study was to compare the effect of a diode laser and traditional irrigants on the bond strength of self - adhesive cement.materials and methodsfifty - five incisors extracted due to periodontal problems were used .
all teeth were instrumented using a set of rotary root canal instruments .
... | pubmed |
in recent years , concerted efforts to identify , describe , and quantify the bacterial communities of the mammalian gastrointestinal tract have begun to bear fruit . many international consortia and collaborations
have been established to answer the question : who is there? hot on the heels of this is the query : ... | the gut microbiota consists of trillions of prokaryotes that reside in the intestinal mucosa .
this long - established commensalism indicates that these microbes are an integral part of the eukaryotic host .
recent research findings have implicated the dynamics of microbial function in setting thresholds for many p... | pubmed |
onychomycosis is a chronic fungal infection of the nail , characterized by nail discoloration , thickening , and defect .
the involved pathogens are dermatophytes , yeasts ( candida ) , and nondermatophytes.1 dermatophytes such as trichophyton rubrum and trichophyton mentagrophytes are the most common agents of onych... | backgrounddistal and lateral onychomycoses are the most frequent forms of onychomycosis , causing subungual hyperkeratosis that usually limits local penetration of antimycotic drugs .
tazarotene exerts anti - inflammatory and immune - modulating activities toward both infective agents and damaged keratinocytes .
gi... | pubmed |
cardiac resynchronisation therapy ( crt ) has become an important treatment for patients with heart failure and left ventricular ( lv ) dyssynchrony [ 13 ] .
however , clinical non - response to crt is reported in 2535 % of patients .
although a large variety of causes for a suboptimal response have been cited , m... | introductionnon response to cardiac resynchronisation therapy ( crt ) may be related to the position of the coronary sinus lead.methodswe studied the acute haemodynamic response ( ahr ) from alternative left ventricular ( lv ) endocardial pacing sites in clinical non - responders to crt .
ahr and the interval from qr... | pubmed |
autosomal dominant polycystic kidney disease ( adpkd ) affects between 1 in every 500 and 1 in every 1000 individuals and is found in all racial and ethnic groups
. the disease may not be clinically apparent until the third or fourth decade of life and only about half of the patients will progress to renal failure . ... | renal disease , either preexisting or occurring during gestation may impair maternal and fetal health . a 35-year - old primigravida with autosomal dominant polycystic kidney disease on hemodialysis was scheduled for emergency cesarean section .
she was managed successfully with low - dose intrathecal bupivacaine and... | pubmed |
it also depicts summary of the pattern of milk yield determined by the biological efficiency of the cow .
the cost of milk production depends to a large extent on the persistency of lactation , that is , the rate of decline in production after peak milk yield .
high persistency is associated with a slow rate of dec... | data pertaining to 11728 test - day daily milk yields of normal and mastitis karan fries cows were collected from the institute herd and divided as mastitis and nonmastitis and parity - wise .
the data of lactation curves of the normal and mastitis crossbred cows was analyzed using gamma type function .
ftdmy in no... | pubmed |
mouse lifespan , weight , and food consumption were monitored as described in detail previously ( 15 ) .
briefly , male b6c3f1 mice ( harlan breeders ; indianapolis ) were randomly assigned to treatment groups at 12 months of age .
two hundred ninety - seven control mice were shifted from ad libitum chow feeding ( ... | mesonordihydroguaiaretic acid ( ndga ) extends murine lifespan .
the studies reported here describe its dose dependence , effects on body weight , toxicity - related clinical chemistries , and mortality - related pathologies . in flies
, we characterized its effects on lifespan , food consumption , body weight , an... | pubmed |
genetic variation contributes to both disease susceptibility and treatment response . genome - wide association studies ( gwas ) have enabled rapid discovery of genetic variants contributing to the pathogenesis of complex genetic diseases ( manolio 2010 ) , as well as detection of many pharmacogenetic markers ( link et... | biomarkers are of increasing importance for personalized medicine , with applications including diagnosis , prognosis , and selection of targeted therapies .
their use is extremely diverse , ranging from pharmacodynamics to treatment monitoring .
following a concise review of terminology , we provide examples and c... | pubmed |
myosin va ( myova ) is a processive molecular motor involved in intracellular cargo transport along the actin cytoskeleton [ 2 , 3 ] .
each dimerized molecule consists of a pair of n - terminal motor domains ( i.e. , heads ) connected to lever arms , followed by a coiled - coil rod domain , ending in a globular c -... | myosin va ( myova ) is a processive molecular motor involved in intracellular cargo transport on the actin cytoskeleton .
the motor 's processivity and ability to navigate actin intersections are believed to be governed by the stiffness of various parts of the motor 's structure .
specifically , changes in calcium ... | pubmed |
the aim of this study was to determine whether clinical outcome after surgical resection of esophageal adenocarcinoma ( eac ) or esophageal squamous cell carcinoma ( escc ) could be predicted by functional polymorphisms in different proto - oncogenes and tumor suppressor genes .
six single nucleotide polymorphisms ( ... | purposethe aim of this study was to determine whether clinical outcome after surgical resection of esophageal adenocarcinoma ( eac ) or esophageal squamous cell carcinoma ( escc ) could be predicted by functional polymorphisms in different proto - oncogenes and tumor suppressor genes.experimental designsix single nucle... | pubmed |
oral cavity is colonized by candida albicans or other candida species in 40 - 60% of healthy persons . in immune - compromised patients , candida species can trigger a variety of disease manifestations ranging from localized mild oral lesion to a disseminated candidiasis.1 many factors contribute to the development of ... | background : the present study was directed to evaluate the forms of oropharyngeal candidiasis ( opc ) and their correlation with cd4 + cell counts in human immunodeficiency virus ( hiv ) patients.materials and methods : this was a descriptive and analytical cross - sectional study carried out for a 2-year period , in ... | pubmed |
breast cancer is the most common cancer among women , with approximately 1.67 million new patients diagnosed annually worldwide and accounting for 25% of all cancer cases.1 breast cancer predominantly spreads via the lymphatic system to locoregional lymph nodes , meaning that the status of these lymph nodes is importan... | introductionbreast cancer staging with sentinel lymph node biopsy relies on the use of radioisotopes , which limits the availability of the procedure worldwide .
the use of a magnetic nanoparticle tracer and a handheld magnetometer provides a radiation - free alternative , which was recently evaluated in two clinical... | pubmed |
visceral adipose tissue - derived serine proteinase inhibitor ( vaspin ) was identified in the visceral adipose tissue of oletf ( otsuka long - evans tokushim a fatty ) rats , an animal model of obesity and type 2 diabetes mellitus ( t2 dm ) .
vaspin is also expressed in the skin , hypothalamus , pancreatic islets , ... | vaspin and adiponectin are two adipocytokines with antidiabetic effects .
some studies reported that levels of adiponectin and vaspin were correlated with decreased glomerular filtration rate ( fgr ) and increased albuminuria .
we therefore evaluated the vaspin and adiponectin levels in renal insufficiency ( ri ) p... | pubmed |
data from two multicenter , double - blind , randomized clinical trials were used to test the surrogate variables proposed for neuropathic dfus and to explore the correlation between granulation tissue development ( the main efficacy variable of the studies ) and complete healing during follow - up for 1 year after the... | objectiveto determine if partial wound closure surrogate markers proposed for neuropathic , small diabetic foot ulcers ( dfus ) can be extended to advanced lesions and if the development of granulation tissue can be used to predict complete healing.research design and methodsdata from two multicenter , double - blind ,... | pubmed |
to date , laparoscopic transabdominal preperitoneal ( tapp ) mesh repair has been regarded as one of the standard treatments for inguinal hernia in adults .
however , patients who undergo the procedure experience a significantly higher incidence of early postoperative pain , which is associated with subsequent chroni... | background and objectives : in recent years , 2 modifications of laparoscopic transabdominal preperitoneal ( tapp ) inguinal hernia repair needlescopic ( ntapp ) surgery and single - port ( stapp ) surgery have greatly improved patient outcomes over traditional approaches . for a comparison of these 2 modifications
... | pubmed |
the breathing process , which begins at the upper airway and culminates in gas exchange inside the alveoli , is essential for the human organism to survive .
when breathing begins through the nose , the air is prepared in order to reach the lungs with the ideal conditions , that is , warmed , moistened , and filtered... | summary
introduction : hyperplasia of the pharyngeal tonsil is one of the main causes of mouth breathing , and accurate diagnosis of this alteration is important for proper therapeutic planning .
therefore , studies have been conducted in order to provide information regarding the procedures that can be used for t... | pubmed |
the incidence of ipsilateral breast tumor relapse ( ibtr ) in patients previously treated for breast carcinoma through breast - conserving surgery , systemic adjuvant therapy and radiation therapy , is estimated to be less than 6% . however , as each case has different clinical relevance ( evolution , prognosis and the... | after breast - conserving treatment , the occurrence of ipsilateral breast tumor relapse raises the concern regarding whether it may represent two distinct types of lesion that it is important to define , a true recurrence ( tr ) or a new primary tumor ( npt ) .
tr and npt have different natural histories , prognosis... | pubmed |
age - related macular degeneration ( amd ) is a leading cause of severe vision loss in people aged 55 years and older in developed countries.1,2 the neovascular form of amd , involving choroidal neovascularization ( cnv ) associated with fluid exudation or bleeding , accounts for the majority of cases of amd - related ... | purposethis study evaluated visual function and anatomic and vision - related quality - of - life outcomes in recalcitrant neovascular age - related macular degeneration ( amd ) subjects switched to aflibercept ( eylea ) from ranibizumab ( lucentis).methodsin a single - center study conducted in barrie , on , 40 patien... | pubmed |
multiple sclerosis ( ms ) is a common autoimmune system disease which affects the central nervous system with network vascular inflammation , demyelination and axonal damage symptoms ( 1 , 2 ) .
it is a chronic disease of the central nervous system and causes severe cognitive and physical impairments ( 3 , 4 ) .
ac... | backgroundmultiple sclerosis ( ms ) is a common autoimmune system disease which affects the central nervous system .
it has been documented that interleukin-25 ( il-25 ) plays key roles in suppressing th1 responses , which is increased during ms.objectivesthe aim of this study was to investigate the c424c / a polymor... | pubmed |
aortic aneurysm ( aa ) can be life - threatening and aorta size is the best criterion for determining if an intervention is necessary to prevent ruptures , dissections or aneurysm - related deaths.1 ) however , even large aas seldom cause symptoms,2)3 ) although the incidence of aortic disease increases with age.4)5 ) ... | background and objectivesscreening strategies for aortic aneurysm ( aa ) according to risk factors and ethnicity are controversial .
this study explored the prevalence of aa and determined whether screening is necessary in a population of multiple risk factors.subjects and methodsfrom june , 2012 to april , 2013 , 54... | pubmed |
in developed countries , endometrial cancer morbidity has exceeded that of cervical cancer to become the most common invasive malignancy of the female genital tract .
early screening methods cervical cancer have made major progress because of the improvement of cytologic preparation methods and unified evaluation sys... | background : the aim of this study was to compare specimen adequacy of sap-1 provided for cytology with that of dilation and curettage ( d & c ) or hysteroscopy for histology , and evaluate the accuracy of combining endometrium sampling by sap-1 and liquid - based cytology using surepath preparation for screening endom... | pubmed |
breast cancer is the most common cancer worldwide among women , with nearly 1.7 million new cases in 2012 .
the highest incidence rates are in europe and north america , and by country are highest in belgium , denmark , and france.1 breast cancer mortality has decreased in some parts of the world , with screening mam... | despite controversy regarding mammography s efficacy , it continues to be the most commonly used breast cancer - screening modality . with the development of digital mammography
, some improved benefit has been shown in women with dense breast tissue .
however , the density of breast tissue continues to limit the s... | pubmed |
over - the - counter ( otc ) cough and cold medications have long been criticized for lack of evidence supporting their efficacy .
this study demonstrates that diphenhydramine indeed inhibits cough reflex sensitivity.diphenhydramine , a commonly - used first - generation antihistamine in the us , is rightfully also c... | background : currently available over - the - counter cough remedies historically have been criticized for lack of scientific evidence supporting their efficacy .
although the first - generation antihistamine diphenhydramine is classified as an antitussive by the united states food and drug administration , to the au... | pubmed |
the global population , especially those in developed countries , is getting older and this trend is predicted to continue in the coming decades [ 1 , 2 ] .
some have defined aging as a decreased ability to resist cellular stresses or insults [ 3 , 4 ] , and in fact , aging is one of the most important cardiovascular... | the endothelium plays a critical role in the maintenance of cardiovascular health by producing nitric oxide and other vasoactive materials .
aging is associated with a gradual decline in this functional aspect of endothelial regulation of cardiovascular homeostasis .
indeed , age is an independent risk factor for c... | pubmed |
axillary lymph node status is the most important prognostic factor in breast carcinoma and prognosis worsens with increasing number of metastatic lymph nodes [ 1 , 2 ] . according to the american joint committee on cancer ( ajcc)/international union against cancer ( uicc ) tumor ( t)-node ( n)-metastasis ( m ) classifi... | we evaluated the prognostic significance of lymph node ratio ( lnr ) , number of metastatic lymph nodes divided by number of removed nodes in 924 breast carcinoma patients with 13 metastatic axillary lymph node(s ) .
the most significant lnr threshold value separating patients in low- and high - risk groups with sign... | pubmed |
the oh functionality is commonly activated by attachment of a good leaving group , e.g. , by conversion into an ester derivative of a strong acid ( tosylate , mesylate , triflate ) , usually employing mitsunobu or appel conditions.1 this classic methodology suffers from poor atom economy and creates large amounts of wa... | abstracta set of phosphatases was evaluated for their potential to catalyze the regio and stereoselective phosphorylation of alcohols using a highenergy inorganic phosphate donor , such as di , tri and polyphosphate .
parameters such as type and amount of phosphate donor and ph of the reaction were investigated in or... | pubmed |
various non - native biological invaders have been noted for centuries , such as the phylloxera ( a homopteran ) that destroyed grapevines and devastated the wine industry in europe in the 1860s and the chestnut blight that entered north america in the early 20th century and virtually eliminated a dominant tree speci... | invasions by non - native species have caused many extinctions and greatly modified many ecosystems and are among the major anthropogenic global changes transforming the earth . beginning in the mid-1980s , a dramatic burst of research in invasion biology has revealed a plethora of previously unrecognized impacts and l... | pubmed |
schwannomas are rare tumors of the nerve sheath that arise from the primary glial cells of the peripheral nervous system . as such
although benign and slow growing , schwannomas can cause significant morbidity due to direct involvement of nerves or by local mass effect that can pose particular challenges for treatmen... | background schwannomas of the vidian canal are an extremely rare type of intracranial tumor that can have variable clinical presentations including headache , facial pain , facial muscle paralysis , decreased lacrimation , or nasal dryness .
we present an atypical case of an incidentally identified asymptomatic vidi... | pubmed |
posterior transpedicular pedicle screw fixation is widely used for obtaining internal fixation for management of the unstable spine mainly caused by trauma , and burst fractures comprise 1020% of such injuries.1 the aims of surgery in these fracture cases include decompression of the neural components , fracture reduct... | background : use of a pedicle screw at the level of fracture , also known as an intermediate screw , has been shown to improve clinical results in managing lumbar fracture , but there is a paucity of biomechanical studies to support the claim .
the aim of this study was to evaluate the effect of adding intermediate p... | pubmed |
the discovery of electrochemical self - assembly
( esa ) of nanostructured
hybrid thin films of inorganic semiconductors and organic dyes has
opened a new synthetic route for obtaining photoanode material for
dye - sensitized solar cells ( dsscs ) .
this method bypasses the high - temperature sintering that i... | nanostructured
hybrid thin films of cuscn and rhodamine b ( rb )
are electrochemically self - assembled ( esa ) by cathodic electrolysis
in an ethanol / water mixture containing cu2 + , scn , and rb . by selecting the solvent , cu2+/scn ratio , and the concentration of rb , we demonstrate several control
parame... | pubmed |
the nasopharyngeal bursa originates from the area of communication between the notochord and the foregut , ie , the pharyngeal endoderm.1,2 it is believed to be a remnant of embryonic communication between the notochord and the roof of the pharynx , that normally disappears during the second month of intrauterine fetal... | nasopharyngeal bursitis is a relatively rare syndrome characterized by a collection of symptoms that multidisciplinary specialists should be aware of . here
we present an audit of cases presenting to a rhinology clinic over a two - year period , as well as an overview of the relevant embryology and different clinical... | pubmed |
the incidence of melanoma skin cancer has been increasing over the past few decades [ 13 ] . estimated 76,250 new cases of invasive melanoma were diagnosed in usa in 2012 , with an estimated number of 9,180 that result in death .
australia has one of the highest rates of skin cancer in the world . over 1,890
the mo... | image - based computer aided diagnosis systems have significant potential for screening and early detection of malignant melanoma .
we review the state of the art in these systems and examine current practices , problems , and prospects of image acquisition , pre - processing , segmentation , feature extraction and s... | pubmed |
type 2 diabetes ( t2d ) is a chronic disease characterized by high blood glucose which is induced by both insulin resistance and relative insulin deficiency , and the complications of t2d , such as cardiovascular disease , renal failure and blindness , always bring heavy burden to society .
the latest studies from th... | mfn2 and esrra are candidate genes involved in the pathogenesis of t2d .
five tag - snps in mfn2 gene and three in esrra gene were selected and genotyped with taqman or pcr - rflp method in stage 1 populations ( 555 patients with t2d and 649 control subjects ) and stage 2 populations ( 546 patients with t2d versus 41... | pubmed |
interindividual variations of ex vivo platelet aggregation during clopidogrel therapy have been correlated to reduced exposure of active clopidogrel thiol metabolite and differences in p2y12 receptor occupancy.1 high on - treatment platelet reactivity during therapy with clopidogrel and low platelet inhibition are asso... | backgroundthe metabolic activation of clopidogrel is a two - step process .
it has been suggested that paraoxonase-1 ( pon1 ) is a rate - limiting enzyme in the conversion of 2-oxo- clopidogrel to an active thiol metabolite .
conflicting results have been reported in regard to ( 1 ) the association of a common poly... | pubmed |
toxoplasmosis is caused by the obligate intracellular protozoan parasite , toxoplasma gondii , for which preferred primary host is a cat and human may become infected as an intermediate host.1 most people with toxoplasmosis are asymptomatic .
however , if a pregnant woman is infected , the parasite can enter the feta... | toxoplasmosis is a rare disease caused by intracellular protozoan parasite , toxoplasma gondii .
though most patients with toxoplasmosis are asymptomatic , congenital toxoplasmosis in the fetus can cause ocular involvement such as chorioretinitis and central nervous system disease including intracerebral calcificatio... | pubmed |
approximately 20 million people ( 10 - 15% of the adult population ) have gallstones and 1 million new patients are diagnosed with cholelithiasis every year . as a result
, the treatment of cholelithiasis has become the most costly digestive disease , with an estimated annual cost of more than $ 5 billion . in septem... | background and objectives : maricopa medical center ( mmc ) was found to have higher charges and length - of - stays than 16 other regional hospitals in an analysis of drg categories for gallbladder disease .
these comparative figures identified mmc as being inefficient and demanded review to determine the reasons fo... | pubmed |
type 1 diabetes is characterized by progressive autoimmune destruction of pancreatic cells that leads to symptoms of insulinopenia when -cell mass is deficient .
glucose homeostasis is restored with administration of exogenous insulin and some patients experience a reduction of their daily insulin requirements ( d... | to evaluate the characteristics and determinants of partial remission ( pr ) in belgian children with type 1 diabetes ( t1d ) , we analyzed records of 242 children from our center .
clinical and biological features were collected at diagnosis and during follow - up .
pr was defined using the insulin - dose - adjust... | pubmed |
oral health is important to the quality of life of individuals of all age groups .
oral lesions can lead to interference of daily activities due to discomfort or pain that interferes with mastication , swallowing , and speech , producing additional symptoms such as halitosis , xerostomia , or oral dysesthesia , which... | backgroundoral health is important to individuals of all age groups .
previous epidemiologic studies of the oral health status of the general population in india provided very little information about oral mucosal lesions in the elderly . hence , the purpose of the present study was to determine the prevalence of the... | pubmed |
chondroblastoma is a rare osseous tumor which accounts for less than 1% of all primary bone tumors , and affects the epiphyseal regions of the tubular bones , especially the ends of tibia , femur , and humerus .
chondroblastoma localized in the head and neck region is uncommon but characteristically occurs in the tem... | we present a case involving a late diagnosis of chondroblastoma of the temporal skull base involving the temporomandibular joint ( tmj ) . following an initial misdiagnosis and unsuccessful treatment over a period of 5 years
, the patient was referred to our department for further evaluation and possible surgical int... | pubmed |
the benefits of regular structured exercise are well documented and include improvements in cardiovascular and metabolic function , which reduce the risk of chronic health conditions such as type 2 diabetes and cardiovascular disease .
recent evidence also demonstrates that exercise alone ( in the absence of concomit... | objective .
epidemiologic studies suggest an inverse relationship between nonalcoholic fatty liver disease ( nafld ) , visceral adipose tissue ( vat ) , and self - reported physical activity levels
. however , subjective measurements can be inaccurate and prone to reporter bias .
we investigated whether objective... | pubmed |
this is a retrospective , observational , consecutive case series conducted in a tertiary eye care hospital in north india .
all patients with history of fireworks - related injuries , who attended the emergency eye care services and outpatient services during the 5 days of the diwali festival 2 days before diwali ,... | purpose : to evaluate the epidemiological characteristics and outcomes of ocular injuries resulting from the use of firecrackers during the diwali festival in all age groups.materials and methods : a single - center , retrospective , hospital - based case series presenting with ocular trauma consequent to fireworks usa... | pubmed |
subclinical hypothyroidism ( sch ) , which is defined as an isolated elevation of thyroid - stimulating hormone ( tsh ) levels with a normal free thyroxine ( ft4 ) level , is a relatively common disorder .
most experts agree that sch represents early , mild thyroid failure and this issue is becoming increasingly re... | subclinical hypothyroidism ( sch ) is a common disorder that is characterized by elevated thyroid - stimulating hormone levels in conjunction with free thyroxine concentrations within the normal reference range .
thyroid hormones are known to affect the heart and vasculature and , as a result , the impact of sch on t... | pubmed |
the anaerobic gram - positive bacillus clostridium difficile is a leading cause of antibiotic - associated diarrhea .
antimicrobial drugs disrupt the normal intestinal flora , allowing c. difficile to flourish and release c. difficile toxin a and toxin b that induce c. difficile - associated diarrhea ( cdad).1,2 alth... | purposethe enzyme immunoassay ( eia ) has lower sensitivity for clostridium difficile toxins a and b than the polymerase chain reaction in the diagnosis of c. difficile - associated diarrhea ( cdad ) .
furthermore , toxin positivity with eia performed on c. difficile isolates from stool cultures may be observed even ... | pubmed |
the design and principal findings of the dream trial have been presented in previous publications ( 17 ) .
briefly , the dream trial was a large , international , multicenter , double - blind , randomized controlled trial designed to determine whether ramipril and/or rosiglitazone could prevent or delay the developme... | objectivethe objective of this study was to determine the degree to which ramipril and/or rosiglitazone changed -cell function over time among individuals with impaired fasting glucose ( ifg ) and/or impaired glucose tolerance ( igt ) who participated in the diabetes reduction assessment with ramipril and rosiglitazone... | pubmed |
microbial communities differ from monocultures in terms of the toxins they degrade ( pelz et al , 1999 ) , the natural products they produce ( pettit , 2009 ) , and even their capacity to grow at all in certain environments ( schink , 2006 ) .
a complete understanding of microbial metabolism must extend from the prop... | mixed microbial communities exhibit emergent biochemical properties not found in clonal monocultures .
we report a new type of synthetic genetic interaction , synthetic mutualism in trans ( smit ) , in which certain pairs of auxotrophic escherichia coli mutants complement one another 's growth by cross - feeding esse... | pubmed |
brook - spiegler syndrome ( bss ) is a rare genodermatosis characterized by the progressive formation of adnexal skin tumors in the scalp and face , mainly trichoepiteliomas , cylindromas and spiradenomas .
it is due to mutations in the tumor suppressor gene cyld ( cylindromatosis gene ) on chromosome 16q12q13 . arou... | brooke spiegler syndrome ( bss ) is a rare genodermatosis characterized by the progressive formation of adnexal skin tumors in the scalp and face , mainly trichoepitheliomas , cylindromas , and spiradenomas .
it has also been associated with salivary glands neoplasms .
it is due to mutations in the tumor suppresso... | pubmed |
biological scaffold materials derived from dermis , pericardium , and small intestine submucosa of human , bovine , and porcine origin have been utilized over the last decade for soft tissue repair applications such as hernia repair , breast reconstruction , staple - line reinforcement , and orthopedic applications .
... | purpose . poly-4-hydroxybutyrate ( p4hb ) is a naturally derived , absorbable polymer .
p4hb has been manufactured into phasix mesh and p4hb plug designs for soft tissue repair .
the objective of this study was to evaluate mechanical strength , resorption properties , and histologic characteristics in a porcine mod... | pubmed |
glycopeptide resistance was detected in enterococci more than 25 years ago , ; since then , vancomycin - resistant enterococci ( vre ) have become important nosocomial pathogens associated with high mortality and costs , , , .
glycopeptide resistance in enterococci is mediated by van genes , with vana and vanb being ... | vancomycin - resistant enterococci ( vre ) are increasingly important nosocomial pathogens and screening for colonization status is a mainstay in infection control .
we implemented pcr - based screening during vana - positive enterococcus faecium outbreaks in four university hospitals in copenhagen , denmark .
xper... | pubmed |
in addition to the circulatory renin - angiotensin - aldosterone system ( raas ) , there is now a significant body of evidence supporting the concept of a local tissue or cellular raas that has important roles in the pathology of cardiovascular diseases .
the local production of aldosterone and the discovery of min... | aims . we evaluated the effects of ru28318 ( ru ) , a selective mineralocorticoid receptor ( mr ) antagonist , captopril ( capt ) ,
an angiotensin converting enzyme inhibitor , and losartan ( los ) , an angiotensin receptor blocker , alone or in combination with ischemia / reperfusion- ( i / r- ) induced cardiac dysf... | pubmed |
modern nasal surgery takes into account the cosmetic appearance of the nose but also seeks to improve the natural functions of the nose .
furthermore , in modern respiratory medicine , objective measurement of airway patency is a must .
measurement of nasal cavity geometry has proven to be a great challenge for res... | objective . to evaluate the changes in nasal dimensions of healthy iranian volunteered for cosmetic rhinoplasty after surgery using acoustic rhinometry
. methods . pre- and postoperative nasal dimension of 36 cases undergoing cosmetic rhinoplasty
were compared using acoustic rhinometry ( ar ) , and the measured var... | pubmed |
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