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We performed a case matching study comparing HCV cirrhotic patients with and without HCC (72 in each group) that were identical in terms of sex, age, BMI and duration of HCV infection. All patients underwent LS measurement, endoscopy, liver imaging and liver function tests. A multiple regression analysis was performed ...
RESULTS
In the HCC group, LS was significantly higher (42 vs 27 kPa, p<0.0001). In the multivariate analysis higher values of LS, alanine-aminotransferase (ALAT), alpha-fetoprotein (AFP) and interquartile range (IQR) of LS measurements were independently associated with the presence of HCC (p<0.0001 for all parameters; Odds Ra...
CONCLUSION
In HCV related cirrhosis, HCC is associated with increased LS and IQR values and high ALAT and AFP levels. By combining these four parameters into a regression model, liver cancer may be noninvasively predicted with good accuracy.062 Impaired apical and basal rotation lead to a reduction in torsion on exercise in patie...
Background Many patients presenting with symptoms of heart failure are found to have normal ejection fraction using standard 2D echocardiography and are labelled as having Diastolic Heart Failure or HFNEF. It is known that apical rotation is reduced at rest and on exercise in these patients. But there are no data on ba...
Introduction: Race walking (RW) is a very peculiar form of locomotion that requires athletes to walk as fast as possible following two main rules: keep the knee of the supporting leg locked “from the moment of first contact with the ground until the vertical upright position”; and, generate a progression of steps with ...
The present study was carried out to investigate the effect of melatonin, a potent antioxidant, and phenytoin, a conventional antiepileptic, against FeCl3-induced posttraumatic seizures. Male Wistar rats weighing 200-250 g were implanted with epidural electrodes and allowed to recover. After the recording of baseline E...
Interleukin-2 (IL-2) is the prototype member of an emerging class of pleiotropic cytokines that have extraordinary immunologic and therapeutic promise (1). An influential guide for much of the research (2) on IL-2 structure and function has been a paper by Brandhuber et al. (3). However, their x-ray structure of human ...
W e hear a lot about the right of people to “die with dignity.” Such discussions usually occur in the context of malignant disease or other major progressive illnesses such as motor neurone disease. In a week in which a report has focused attention on the care of elderly people (see BMJ 2006;332: 746), it is surely wor...
> There needs to be a sort of “Do not attempt aggressive medical treatment” order that could be applied to frail people in the community
Frail …Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice.
The mouse Lupo (I282N) mutation in proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2) leads to reduced expression of PSTPIP2 that is associated with a macrophage-mediated autoinflammatory disease. Another mutation in PSTPIP2, L98P, termed chronic multifocal osteomyelits (cmo), leads to a disease in mi...
Abstract GENERATIONS IN TOUCH: LINKING THE OLD AND THE YOUNG IN A TOKYO NEIGHBORHOOD. By Leng Leng Thang. Ithaca and London: Cornell University Press, 2001, 209pp., pbk £10.95 ISBN 0 8014 8732 3., by Leng Leng Thang Reviewed by Stephen W. Ellis. LEGACY:INSPIRINGSOCIALCHANGEINTHEU.S.ANDABROAD.A Film by Tod Lending. Revi...
Cs atoms were optically pumped with a Ti:sapphire laser in a magnetic field of 1.516 T. Steady absorption spectra and populations of Zeeman sublevels of the ground state of Cs in N2 gas at various pressures (5, 40, and 80 Torr) were obtained. The results show that in a high magnetic field, the combined electron-nuclear...
The technical feasibility of graphically displaying information such as surrounding aircraft and navigation routes in the cockpit on a cathode ray tube has been suggested as a viable method for improving the safety, orderliness, and expeditiousness of the air traffic control system by distributing some of its managemen...
The drying dynamics of protein coatings is of importance for many applications. The main focus of research so far was to investigate macroscopic properties of protein coatings, leaving drying dynamics virtually unexplored. A unique combination of techniques is used to monitor drying of a coating containing the protein ...
Structural echoes of underwater elastic targets, used for detection and classification purposes, can be highly localized in the time-frequency domain and can be aspect-dependent. Hence such structural echoes recorded along a distributed (synthetic) aperture, e.g., using a moving receiver platform, would not meet the st...
The purpose of the current study was to examine grandparent support to grandchildren following the divorce of parents. Participants (N = 42) responded to questions focusing on the enactment of support and relationships with grandparents. Through these retrospective, self-report accounts, six categories of grandparent s...
Lactic acid is a product that has several applications in food, cosmetic, pharmaceutical and chemical industries. The main objective of this work was to evaluate the potential use of sap of oil palm ( Elaeis guineensis ) as a substrate for lactic acid production by Lactobacillus casei TISTR 1500. The effects of constan...
To examine the antecedents and consequences of the development of salespeople's organizational commitment during early employment, the authors conducted a longitudinal study. The study focused on how changes in three key antecedents (leadership behavior, role stress, and job satisfaction) influence the development of c...
Bureaucracy — The Career of a Concept is for the most part Krygier's doctoral thesis in the history of ideas, “Marxism and Bureaucracy.” Krygier's chapters, the core of the book, proceed as follows. First, bureaucracy is placed in its etymological and organizational contexts. The concept is then pursued through Saint-S...
A clinicomorphological analysis was performed of the gastric antrum mucous membrane of 60 patients after selective proximal vagotomy because of stenosing duodenal ulcer. The patients were subdivided into two randomized groups depending on the type of the draining operation. The first group had a gastroduodenoanastomosi...
BACKGROUND
Obesity is associated with an increased risk of work disability, but studies concerning weight change are few. We examined the associations of weight change with subsequent sickness absence.
METHODS
Weight status data of 4164 (83% women) employees of the City of Helsinki were gathered from the Helsinki Health Study baseline survey in 2000-2002 and follow-up survey in 2007. Data were linked prospectively with the employer's sickness absence registers. Employees were categorized according to their baseline Body Mass...
RESULTS
Among women, those who maintained normal weight had the lowest risk for sickness absence. Weight loss, weight gain and stable obesity increased the risk for sickness absence spells of all lengths. Adjustments for covariates attenuated the association only slightly. Among men, the achieved results were mostly not statis...
CONCLUSIONS
Preventing obesity and weight gain is important for employee well-being and work ability. Early support measures in occupational health care could benefit obese employees and those with weight gain to maintain work ability. The association between weight loss and sickness absence should be corroborated in further studi...
Objectives: The acute‐phase reactant C‐reactive protein (CRP) is currently the serum variable of choice for an early, accurate, and cost‐effective severity assessment of acute pancreatitis in the daily clinical routine. Serum amyloid A (SAA) proteins comprise a family of apolipoproteins that constitute another major ac...
ABSTRACT UK governments have often claimed that humanitarian intervention – without the consent of the target state and if necessary without express UN Security Council authorization – is legally permissible in exceptional circumstances, a stance that is highly controversial. The UK’s position is at odds with prevailin...
This review describes principles of echocardiography and Doppler, outlines the techniques of echo-Doppler studies, presents methods of assessment of pressure in the pulmonary artery, reviews methodology for appraisal of ventricular function, and demonstrates the usefulness of echo in evaluating multiple neonatal issues...
Although there can be few practising clinicians in Scotland today who have not become familiar with the problem of patients with inoperable lung cancer, it remains a fact that only a small minority of such patients enter clinical trials aimed at improving therapy. This is despite (some would say because of) the depress...
EDITOR—In their editorial on the tobacco industry in developing countries Sebrie and Glantz did not take into account potential positive effects and disregarded important accomplishments of Mexico's health ministry in tobacco control.1
Over the past five years, the ministry, under the leadership of the current minister of public health, Julio Frenk, has implemented several tobacco control initiatives. A tax increase on tobacco products reversed an …Auditory Environment Across the Life Span of Cochlear Implant Users: Insights From Data Logging.
Purpose
We describe the natural auditory environment of people with cochlear implants (CIs), how it changes across the life span, and how it varies between individuals.
Method
We performed a retrospective cross-sectional analysis of Cochlear Nucleus 6 CI sound-processor data logs. The logs were obtained from 1,501 people with CIs (ages 0-96 years). They covered over 2.4 million hr of implant use and indicated how much time the CI users had spent in various acoustical environments. We investi...
Results
CI users spent a substantial part of their daily life in noisy environments. As a consequence, most speech was presented in background noise. We found significant differences between age groups for all auditory scenes. Yet even within the same age group and country, variability between individuals was substantial.
Conclusions
Regardless of their age, people with CIs face challenging acoustical environments in their daily life. Our results underline the importance of supporting them with assistive listening technology. Moreover, we found large differences between individuals' auditory diets that might contribute to differences in rehabilitat...
During our search for novel myxobacterial natural products, we discovered the thiamyxins: thiazole- and thiazoline-rich non-ribosomal peptide-polyketide hybrids with potent antiviral activity. We isolated four congeners of this unprecedented natural product family with the non-cyclized thiamyxin D fused to a glycerol u...
The article examines the factors that determine gender equality in the system of
state policy, and determines its role and place in state policy. The effective use of the
potential of Ukrainian citizens - men and women - in state policy and management is
hindered by the double standards that exist in our society, when the equality of rights and
opportunities for people of both sexes is officially recognized, but is rejected in everyday
practices based on traditional ideas about the roles of men and women in the family and
society. The contradiction between the existence of an objective request of society for a
wider use in public management of social resources, including gender, and the insufficient
development of this topic in domestic scientific researches of politics and public
administration is determined.Laser interferometric gravitational wave detectors