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The Open University's repository of research publications and other research outputs The oxygen isotope composition of dark inclusions in HEDs, ordinary and carbonaceous chondrites Conference Item Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owne... |
Intratumoral physical engagement of T cells with immunosuppressive neutrophils is associated with reduced effector function. Interior tumor views Previous studies indicate that a high frequency of intratumoral neutrophils is associated with a poor clinical prognosis. Si et al. used a variety of microscopy and imaging t... |
In this letter, a novel post-CMOS silicon-embedded coreless power inductor is proposed and demonstrated. The inductor is fabricated in the thick bottom layer of a silicon substrate and connected to the front side through vias opened in the thin top layer where control circuits can be fabricated for chip area saving. A ... |
OBJECTIVE |
To investigate the effectiveness of phosphorothioate multidrug resistance gene 1 (MDR1) antisense oligodeoxynucleotides (MDR1-AS) suppressing MDR1 expression in multidrug-resistant glioma cell line C6/adr. |
METHODS |
The glioma cell line C6/adr served as the tested model in vitro, MDR1-AS (5'-CTCCATCACCACCTC-3'), complementary to the -9- +6 sequence of first exon, was synthesized and phosphorothioate-modified. As control of sequence specificity, MDR1-S (5'-GAGGTGGTGA TGGAG-3') was used. Both antisense and sense oligodeoxynucleotide... |
RESULTS |
No cytotoxicity of MDR1-AS was observed. The MDR1 mRNA expression level was decreased from 106% to about 30.44% 48 h after MDR1-AS treatment. The P-gp positive rate of MDR1-AS treated C6/adr cells decreased from 100% to 32.77%, with that of C6/adr cells considered as 100%. |
CONCLUSIONS |
MDR1-AS can effectively inhibit MDR1 expression in the C6/adr cell line at both the mRNA and protein level, and may be an alternative treatment of drug-resistant gliomas.Aerobic fitness, upper-body strength and agility predict performance on an occupational physical ability test among police officers while wearing pers... |
BACKGROUND |
Police institutions often use Occupational Physical Ability Tests (OPATs) as a measure of occupational performance. These tests are utilized to mimic the daily and essential tasks performed by the police officers, but few are performed with load carriage (LC). The purpose of this study was to examine the physical perfo... |
METHODS |
Thirteen federal highway police officers (age: 36.8±3.7 years, body mass: 89±10.7 kg, height: 180±5.6 cm) volunteered to complete a battery of physical fitness tests (aerobic power and capacity, muscular endurance, lower limb power, upper limb strength, agility and anaerobic power) and anthropometrics. Occupational per... |
RESULTS |
Agility (P<0.01), lower limb power and height (P<0.05) were significantly related to performance in the NPPE OPAT. In the WPPE condition, aerobic power (absolute and relative) (P<0.01), lower limb power and agility (P<0.05). The best predictors for OPAT performance were agility (R2=0.45, P<0.01) in the NPPE condition, ... |
CONCLUSIONS |
Different conditions of LC have distinct occupational performance predictors. Thus, considering LC, physical exercise programs aimed at improving police occupational performance should aim at improving agility, upper limb strength and aerobic fitness.Small bowel obstruction and abdominal pain after robotic versus open ... |
Abstract Objective The aim of this study was to examine whether intraperitoneal robot-assisted surgery leads to small bowel obstruction (SBO), possibly caused by the formation of intra-abdominal adhesions. Materials and methods In total, 7256 men treated by intraperitoneal robot-assisted radical prostatectomy (RARP) an... |
Energy-Saving Glass (ESG) is used to prevent the penetration of infrared (IR) radiation into buildings and hence to maintain thermal comfort. ESG is made of float glass with metallic-oxide coating over it. Unfortunately RF/microwave signals are attenuated by this coating making communication more difficult. Multi-layer... |
OBJECTIVE |
To construct a kind of bone healing enhancing implant with cultured chondrocytes bound to hydroxyapatite (HA). |
METHODS |
Chondrocytes were obtained from the costicartilage of rat and were cultured on the porous HA blocks, 3 mm x 3 mm x 4 mm size, for three and seven days. Scanning electron micrograph was taken to show whether the cells grew outside and inside the pore of HA block. The cells cultured on tiny glass sheet for 2 days were us... |
RESULTS |
Scanning electron micrographs showed that the pores of the HA surface and inside of the blocks are filled with cultured cells, especially the longer cultured block. The cells were chondrocytes confirmed by in situ hybridization. |
CONCLUSION |
The porous HA can be used as cell cultured substrate and chondrocyte can adhere and proliferate inside the porous HA block.[Organ transplantation. One of the biochemical reasons for the race against the clock]. |
The authors have studied the subcellular functioning of human adrenal glands removed from subjects in a stage IV coma. The present study has a two-fold interest: on the one hand, it offers biochemical information on a key element in the intermediate metabolism (namely, the mitochondrial energetic metabolism, occurring ... |
Most of the literature on healthcare digitalization is focused on the benefits, the barriers and the determinants of the adoption of ICT-based solutions within hospitals. Little is understood about how hospital digitalization can be accomplished or how this digitalization fosters an increase in hospital performance — b... |
Resveratrol (RES) is a phytoestrogen that has the ability to bind to estrogen receptors (ERs) and evoke biological effects that parallel those exerted by endogenous and synthetic estrogens. We have shown in previous studies that adult female rats acutely exposed to RES exhibit estrous cycle irregularity, ovarian hypert... |
Cleft lip is a congenital development defect. Primary cleft lip repair leads to cleft scar formation. The resulting scar often undergoes hypertrophy, which negatively affects the facial aesthetics, function, and patient's mental health. One of the methods used in scar therapy described in recent years is Botulinum toxi... |
Background: To assess the analgesic efficacy and side effects of buprenorphine and procaine in patients with acute pancreatitis. Methods: Forty patients (average age, 50 years; 23 male) with acute pancreatitis or an acute bout of a chronic pancreatitis were prospectively randomized to receive buprenorphine or procaine ... |
A stochastic stage-dependent model of spread of an epidemic in a certain region is presented. The model is written in the form of a continuous-discrete random process that takes into account the passage of individuals through various stages of an infectious disease. Within the framework of the model, the population of ... |
Trait aggressiveness and hockey penalties: predicting hot tempers on the ice. |
Previous studies examining the validity of measures of trait aggressiveness either have been retrospective studies or have used laboratory aggression as the criterion behavior. Can a measure of trait aggressiveness predict nonlaboratory physical aggression? The Physical Aggression subscale of the Aggression Questionnai... |
Crowd density estimation has gained much attention from researchers recently due to availability of low cost cameras and communication bandwidth. In video surveillance applications, counting people and creating a temporal profile is of high interest. Surveillance systems face difficulties in detecting motion from the s... |
We present a voting scheme in which shares of the ballots are sent to multiple talliers. The talliers operate in parallel and cooperate together to count the ballots by using the technique of the Secure Multiparty Computations (SMPC) in the Virtual Ideal Functionality Framework (VIFF). The counting process is fair sinc... |
An intravascular MRI (IMRI) loopless antenna is combined for the first time with an intravascular water-cooled ultrasound ablation transducer as a possible tool for providing high-resolution MRI-guided ablations of pathological tissue via intravascular access. High resolution anatomical MRI, and real-time MRI thermomet... |
In Hong Lou Meng, the straightforward description of the appearances of young women characters is highly prevalent ; Cao used rhetorical devices of metaphors and similes to present abstract beauty into something visual. As English and Chinese culture and the norms of works of literature do not share the same standard o... |
ABSTRACT Purpose/Aims: To determine the incidence of corneal graft rejection in patients with approximately 1 year of steroid therapy following uDSEK. A shortened course of corticosteroids may be beneficial and a viable option in Ultrathin Descemet’s Stripping Endothelial Keratoplasty (uDSEK). Materials and Methods: Th... |
Stellar population and the interstellar gas-dust medium in the vicinity of the open star cluster vdB 130 are analysed using optical observations taken with the 6-m telescope of the SAO RAS and the 125-cm telescope of the SAI MSU along with the data of Spitzer and Herschel. Based on proper motions and BV and JHKs 2MASS ... |
We study the process of magnetic reconnection in a coalescing magnetic island setup by means of numerical simulation. This process mimics flux tube merging which can take place in the solar corona, laboratory, and astrophysical objects. Simulations are performed with magnetohydrodynamics (MHD), Hall-MHD, and a newly de... |
Barasertib, an aurora B inhibitor, terminates cell division, introduces polyploidy, and consequently causes apoptosis. In the present study, we evaluated the effect of the combination of barasertib and cytarabine (ara‐C), a key agent for leukemia chemotherapy, on leukemic cells in vitro. Human leukemia HL‐60 cells and ... |
Virgin and recycled polyethylene terephthalate (PET) has been examined for the production of composites with additions of 5-20% by weight of sand particles. Density and compressive strength were estimated using virgin (V-PET) and recycled PET (R-PET). Scanning electron microscope (SEM) equipped with energy dispersive X... |
Although no hypothesis is universally accepted, allergic rhinitis (AR) may play an important role in the occurrence of rhinosinusitis. This study was carried out to investigate the frequency and severity of rhinosinusitis among patients with seasonal or perennial AR. This study included 73 patients with AR. Findings re... |
Ovarian stimulation in cases of poor ovarian responsiveness is an important challenge in in-vitro fertilization (IVF) programmes. Despite improvements in oocyte number and quality, an ideal ovarian stimulation strategy has yet to be defined. Here, the results of ovarian stimulation with recombinant follicle stimulating... |
Abstract Creatine deficiency syndromes are congenital metabolic diseases characterized by decreased cerebral creatine levels as a result of disorders in creatine synthesis and transport. Therefore, magnetic resonance spectroscopy is a valuable tool for diagnosis. This disease can be explained by congenital disorders oc... |
Rapid growth of available geospatial data requires a development of system capable of autonomous data retrieval, integration and validation. Since agent technology may provide the suitable framework for developing such a system (as it can deal in a natural way with the distributed heterogeneous nature of the data) a pr... |
vector spaces, extension of positive linear forms, locally convex topological vector spaces, separation of convex sets in a locally convex topological vector space, compact convex sets, the Krein-Milman theorem, seminorms and duality in topological vector spaces. In Chapter 4, the basic theory of normed linear spaces, ... |
Diversity is a good approach to cope with fading and interference, which has widely been used in terrestrial wireless communication systems. Recently, this technique has been taken into account in mobile satellite communication systems. This paper proposes three kinds of diversity methods, named satellite transmitting ... |
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