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Brittleness source identification is the work of finding every brittle source. The key of analysis of the brittleness of system is to build the brittle model. The chart theory can describe the direction and weigh of the brittle spread model. In this paper, bring forward the method and step of building the brittle model... |
Activated T cells are crucial for the development of allergic diseases. We have recently clarified that L-type amino acid transporter 1 (LAT1) plays a functional role in activated T cells. Here, we comparatively investigated the effect of a LAT1 inhibitor, JPH203, on allergic inflammation induced in multiple organs, su... |
1. The effect of a alpha-human atrial natriuretic peptide (1-28) (ANP) on human vasculature was investigated in vivo and in vitro. Possible involvement of vascular dopamine receptors and the renin-angiotensin system in the response to ANP was also studied in vivo. 2. Forearm blood blow was measured by venous occlusion ... |
ABSTRACT The Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER) and Center for Biologics Evaluation and Research (CBER) released a draft guidance (DG) on adaptive clinical trials (ACT) for drugs and biologics in February, 2010. In May, 2016, FDA Center for Devices and Radiological Heath (... |
The present study was designed to investigate the modifying effects of dietary exposure to NaCl and four kinds of crude salts on the induction and development of aberrant crypt foci in Fischer 344 rats. A total of 57 male rats were divided into five groups at six weeks of age, and all were given weekly injections of az... |
B-non-Hodgkin lymphomas (B-NHLs) use a raft-associated signalosome made of the constitutively active Lyn kinase, the tyrosine phosphorylated Cbp/PAG adaptor, and tyrosine phosphorylated STAT3 transcription factor. No such "signalosome" is found in rafts of ALK(+) T lymphoma and Hodgkin-derived cell lines, despite simil... |
This article presents a novel and compact microstrip bandpass with enhanced upper stopband characteristics to fulfil the requirements of the WLAN/5G Wi-Fi. The proposed bandpass filter (BPF) uses the stepped-impedance resonators and the stub-loaded resonators to achieve the desired BPF response for 5G Wi-Fi and WLAN ap... |
Due to the crossbar organization of typical multiprocessors, their cost grows as the square of the number of processors. The distributed pipeline (DP) is a concept which allows the construction and operation of very large multiprocessors; an example having 300 CPU's is described. The DP is an extension of the more trad... |
Laminins are glycoproteins found in basement membranes where they play a vital role in tissue architecture and cell behavior. Previously, we reported the association of two polymorphisms (rs659822 and rs944895) in the laminin alpha5 (LAMA5) gene with anthropometric traits, fasting lipid profile, and glucose levels in p... |
The pathogenesis of immunodeficiency associated with human immunodeficiency virus (HIV) infection remains incompletely understood. CD154, a molecule that is expressed primarily on activated CD4(+) T cells, is pivotal for regulation of cell-mediated and humoral immunity and is crucial for control of many opportunistic i... |
As illustrated in this issue of the Journal1,2, recent advances in prenatal imaging, both twoand threedimensional ultrasound, have allowed a more accurate anatomical approach to fetal cerebral structures, especially the fetal posterior fossa. For instance, such anatomical landmarks as the position of the tentorium or t... |
Launched in March 2010 by the European Commission, the Europe 2020 strategy aims at achieving “smart, sustainable and inclusive” growth. This growth is intended to be driven by three sets of engines: knowledge and innovation, a greener and more efficient use of resources and higher employment combined with social and t... |
We report on a 63-year-old man with von Recklinghausen neurofibromatosis who developed a carcinoid tumor in the periampullary region and multiple small-sized leiomyomas in the duodenal wall. A high prevalence of gastrointestinal carcinoids has previously been recognized in patients with von Recklinghausen neurofibromat... |
The advancement of technologies has continued to affect the performance of efficient healthcare systems globally. Meanwhile, the privacy and security of patients' data has recorded key concerns for most users of health information management system. There is no gainsaying the fact that security is essential in patient ... |
The in situ hybridization technique (ISH), using specific chromosome DNA probes on stained bone marrow or peripheral blood smears, allow us to correlate morphological findings with the cytogenetic abnormalities detected by conventional cytogenetic analysis. We have applied this methodology to study three patients, two ... |
Mining and smelting effluent have resulted in heavy metal-contaminated groundwater. Copper-polluted groundwater poses a severe threat to human health and the ecological environment. Permeable reactive barrier (PRB) has been rapidly developed as the in situ remediation technology to control toxic copper migration. Low c... |
The Mouse Resource Browser MRB (http://bioit.fleming.gr/mrb) is an easy-to-use database for searching and retrieving mouse resource information. Currently, MRB hosts a list of 200 mouse resources which are divided in 33 different categories. Apart from core information such as URL(s), contact information and free text ... |
Women's labour force participation rate declines steeply in the 15 years preceding their state pensionable age, in spite of their generally lacking childcare responsibilities during this stage of the life course. Employment of women in the years following childrearing is important in enabling women to obtain a signific... |
Purpose |
Three adjustment modes are alternatives for mixed-model assembly lines (MMALs) to improve their production plans according to constantly changing customer requirements. The purpose of this paper is to deal with the decision-making problem between these modes by proposing a novel multi-classification method. This method... |
Design/methodology/approach |
The decision-making method uses the classification model composed of an input layer, two intermediate layers and an output layer. The input layer describes the assembly line in a knowledge-intensive manner by presenting the impact degrees of production parameters on line performances. The first intermediate layer provi... |
Findings |
The proposed method achieves higher classification accuracies than the support vector machine methods and the traditional SVDD method in the numerical test consisting of data sets from the machine-learning repository and the case study of a diesel engine assembly line. |
Practical implications |
This research recommends appropriate adjustment modes for MMALs in response to customer demand changes. According to the suggested adjustment mode, the managers can improve the line performance more effectively by using the well-designed optimization methods for a specific scope. |
Originality/value |
The adjustment mode decision belongs to the multi-classification problem featured with limited historical data. Although traditional SVDD methods can solve these problems by providing the posterior possibility of each classification result, they might have poor classification accuracies owing to the conflicts and uncer... |
PROJECT COMPLETION REPORT |
This project supported an in-depth review of the technologies and processes used in the small scale sector which lead to the up-take of coal/boiler waste fired clamp technology in Zimbabwe. These informed the detaile ddevelopment of project work in Latin America and identified gaps in existing knowledge and practise. F... |
Many industries mix granular materials of different sizes and shapes. Product quality and consistency are often compromised by demixing of constituent components. Not only is this practically problematic but it is also philosophically unsettling, for on smaller colloidal scales, systems consisting of particles differin... |
Providing a plurality of types of optical waveguide having a core portion (core portion wherein adjacent groups have the same core structure), the optical waveguide is defined as: minimum value D a minimum distance between the centers of adjacent cores is 15μm to 60 m; the core portion having a radius of curvature R is... |
Privacy of the outsourced data is one of the major challenge. Insecurity of the network environment and untrust-worthiness of the service providers are obstacles of making the database as a service. Privacy concerns exist wherever personally identifiable information is collected and stored. Public databases and resourc... |
© 2013 uhero.hawaii.edu Solar photovoltaic (PV) tax credits are at the center of a public debate in Hawai‘i. The controversy stems largely from unforeseen budgetary impacts, driven in part by the difference between the legislative intent and implementation of the PV tax credits. HRS 235-12.5 allows individual and corpo... |
Gravitational lensing by massive galaxy clusters is a powerful tool for the discovery and study of high-redshift galaxies, including those at z ≥ 6 likely responsible for cosmic reionization. Pelló et al. recently used this technique to discover a candidate gravitationally magnified galaxy at z = 10 behind the massive ... |
ABSTRACT We are facing a global water crisis exacerbated by hydro-climatic extremes related to climate change. Water scarcity is expected to increasingly affect indigenous and marginalized populations. Supporting the sovereignty of indigenous and rural populations to create water secure futures through place-based know... |
subsequent 5-day course of i.v. immunoglobulins (2 g/kg total dose) resulted in only a short-lived improvement in platelet count and no improvement in renal function. Throughout her admission, our patient had rigid anticoagulation with low molecular weight heparin, with factor Xa and platelet monitoring. Despite docume... |
Pathological missense mutations in CLCNKB gene give a wide spectrum of clinical phenotypes in Bartter syndrome type III patients. Molecular analysis of the mutated ClC‐Kb channels can be helpful to classify the mutations according to their functional alteration. We investigated the functional consequences of nine mutat... |
Gastrointestinal side effects are common to all nonsteroidal anti-inflammatory drugs (NSAID). Relevant to the patient are NSAID-induced dyspepsia and ulcer complications such as hemorrhage and perforation. The most important prophylactic means is repeated verification that the NSAID cannot be replaced by other measures... |
Dr. D. Hillion, Department of Nephrology, Centre Hospitalier Intercommunal de Poissy, 10, rue du Champ Gaillard, F-78303 Poissy (France) Dear Sir, Since 1977, amyloid deposits in the transverse carpal ligament of patients on regular dialysis treatment (RTD) were reported. Two unanswered questions persist: (1) Are they ... |
Violence and housing insecurity are horrible events that may be intertwined, with violence possibly forcing victims to abandon their accommodations and housing insecurity depriving people of the safety of a home or placing them in compromised circumstances. This study uses national, prospective, longitudinal data from ... |
This paper presents the results of modeling a shear-mode MR damper. The prototype damper consists of two steel parallel plates and in the middle, there is a paddle covered by foam saturated with MR fluid. The force is produced when the paddle is in motion and the magnetic field generated by a coil in one end of the dev... |
When planning robotic grasping and manipulation maneuvers, knowledge of the shape and pose of the object of interest is critical information. In order for an autonomous or semi-autonomous system to operate intelligently in an unstructured environment and interact with novel objects, it must have the ability to recover ... |
Abstract Reactive oxygen species (ROS) are involved in both bone and cartilage physiology and play an important role in the pathogenesis of osteoporosis and osteoarthritis. The present study investigated the effect of running exercise on bone and cartilage in heterozygous manganese superoxide dismutase (SOD2)-deficient... |
A pilot-scale anaerobic dynamic membrane bioreactor (AnDMBR) was monitored at ambient temperature to assess domestic sewage treatment from a housing development. The dynamic membrane (DM) was developed from polypropylene support material with an average opening of 90 μm, inside an external configuration module. To mini... |
ABSTRACT The English language has developed and spread around the world as a global language. As a variety of English in China, it has also formed some distinct features. This paper first introduces the status quo of the English language in China, and then by analysing the use of four Chinglish idioms on the Internet, ... |
In this paper, a constrained receding horizon output feedback control method which is based on a state observer is suggested. The proposed method adopts the receding horizon dual-mode paradigm which consists of a 'feasible invariant set' and 'free control moves'. Polyhedral feasible invariant sets of estimated state ar... |
Although steam methane reforming (CH4 + 2H2O → 4H2 + CO2) is the most commercialized process for producing hydrogen from methane, more than 10 kg of carbon dioxide is emitted to produce 1 kg of hydrogen. Methane pyrolysis (CH4 → 2H2 + C) has attracted much attention as an alternative to steam methane reforming because ... |
Eight fresh-frozen cadaver legs (average age 72 years) were used to evaluate the risk to the popliteal artery related to the use of two all-inside meniscal repair devices, the Mitek RapidLoc (12.5 mumudegrees) and the Smith & Nephew FasT-Fix (curved). The lumen of the femoral artery was injected with barium. Anteropost... |
In this paper, we generalize the method of moments (MOM) based on the surface integral equation (SIE) method to investigate the scattering properties of complicated shaped biological cells illuminated by a Laguerre-Gaussian beam (LGB). We introduce the Lorentz-gauge vector potential with slowly varying envelope amplitu... |
The purpose of this study was to determine the survival and prognostic factors of patients with diffuse large B-cell lymphoma (DLBCL) of the oral cavity and maxillofacial region. Retrospectively, the clinical records of patients with a primary diagnosis of DLBCL of the oral cavity and maxillofacial region treated at th... |
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