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Equol could reduce female LDLR KO hamster blood lipid. It may play a role in lipid lowering by inhibiting cholesterol absorption besides estrogen receptor pathway, but it is weaker than NPC1 L1 inhibitor. At the same time, up-regulation of ApoAI inhibits the decrease of high-density lipoprotein and reduces lipid accumu... |
Heparin is one of the most frequently used anticoagulants. It is easy to use, but can be associated with life-threatening side effects. One of these is heparin-induced thrombocytopenia syndrome (HITS), which develops in about 3-5% of patients exposed to heparin and is associated with thrombosis in 1% of cases. We repor... |
The luteinizing hormone (LH) receptor plays an essential role in male and female gonadal function. Together with the follicle-stimulating hormone (FSH) and thyroid stimulating hormone (TSH) receptors, the LH receptor forms the family of glycoprotein hormone receptors. All glycoprotein hormone receptors share a common m... |
Aeronautics is actually facing a confluence of events: connectivity of aircraft is gradually increasing in order to ease the air traffic management and aircraft fleet maintainability, and to offer new services to passengers while reducing costs. The core avionics functions are thus linked to what we call the Open World... |
IMPORTANCE |
Little is known about the deadoption of ineffective or harmful clinical practices. A large clinical trial (the Normoglycemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation [NICE-SUGAR] trial) demonstrated that strict blood glucose control (tight glycemic control) in patients admitted to ad... |
OBJECTIVE |
To evaluate glycemic control in critically ill patients before and after the publication of clinical trials that initially suggested that tight glycemic control reduced mortality (Leuven I) but subsequently demonstrated that it increased mortality (NICE-SUGAR). |
DESIGN, SETTING, AND PARTICIPANTS |
Interrupted time-series analysis of 353,464 patients admitted to 113 adult ICUs from January 1, 2001, through December 31, 2012, in the United States using data from the Acute Physiology and Chronic Health Evaluation database. |
MAIN OUTCOMES AND MEASURES |
The physiologically most extreme blood glucose level on day 1 of ICU admission defined glycemic control as tight control (glucose level, 80-110 mg/dL; to convert to millimoles per liter, multiply by 0.0555), hypoglycemia (glucose level, <70 mg/dL), and hyperglycemia (glucose level, ≥180 mg/dL). Temporal changes in each... |
RESULTS |
Before the publication of Leuven I, 17.2% (95% CI, 16.2%-18.2%) of ICU admissions had tight glycemic control, 3.0% (95% CI, 2.6%-3.5%) had hypoglycemia, and 40.2% (95% CI, 38.8%-41.5%) had hyperglycemia. After the publication of Leuven I, there were significant increases in the relative proportion of admissions with ti... |
CONCLUSIONS AND RELEVANCE |
Among patients admitted to adult ICUs in the United States, there was a slow steady adoption of tight glycemic control following publication of a clinical trial that suggested benefit, with little to no deadoption following a subsequent trial that demonstrated harm. There is an urgent need to understand and promote the... |
Young Sahelian farmers are crossing the Sahara toward Europe. They are sold as slave labor, held ransom for money from their families, beaten and spit on. Many die in the desert or drown at sea. Yet, knowing the dangers, they go. The media depicts them as “climate refugees”—running from climate stress. These emigrants ... |
The31P n. m. r. spectrum and spin–lattice relaxation time in polycrystalline P4S3 have been measured between 77 and 500 K in the range 7 to 25 MHz. In phase II the31P n. m. r. spectra and second moments are dominated by the anisotropic chemical shift interactions. Close to the first-order phase transition at 314 K the ... |
The first mitochondrial (mt) genomes of demosponges have recently been sequenced and appear to be markedly different from published eumetazoan mt genomes. Here we show that the mt genome of the haplosclerid demosponge Amphimedon queenslandica has features that it shares with both demosponges and eumetazoans. Although t... |
A suite of compressional and shear phase arrival times (P, S, PP, PeP, SS, SeS, PKPab, 1 PI< P be, PI< Pdf, S I< S ae) and two sets of differential times ( S S S41oS, S S S66oS) are used to infer lateral variations in P and S velocity structure in the entire Earth (crust, mantle, and core). Volumetric heterogeneity is ... |
In spite of the progress in antibiotic therapy and immunoprophylaxis Neisseria meningitidis remains one of the major causes of meningitis and sepsis burdened by high mortality. In this paper characteristics of N. meningitidis and in particular its epidemiology, virulence factors, antibiotic therapy and resistance mecha... |
Abstract Radio frequency interference (RFI) is a well-known risk for wireless medical telemetry, particularly for older telemetry systems still operating in the Private Land Mobile Radio Service (PLMRS) frequencies between 450 and 470 MHz. Testing was performed with medical telemetry systems at two local hospitals usin... |
The results of an ab initio study of the magnetic hyperfine structure of the X2Π electronic state of HCCS and DCCS are reported. The potential surfaces for two components of the X2Π electronic state and the electronically averaged hyperfine coupling constants for H, D, 13C and 33S are obtained as functions of two bendi... |
The glucose sensor HEXOKINASE1 (HXK1) integrates myriad external and internal signals to regulate gene expression and development in Arabidopsis thaliana. However, how HXK1 mediates glucose signaling in the nucleus remains unclear. Here, using immunoprecipitation-coupled mass spectrometry, we show that two catalytic su... |
Literary criticism at the present moment seems ready to open its doors once again to the outside world, even if that world is only a series of other academic disciplines, each cloistered in its own way. For the reader of black African literature in French, the opening comes none too soon. The program for reading Camara... |
In order to quantitate the feedback effect of estradiol (E2) on the release of LH, serum LH and E2 were measured in 27 ovulatory women daily during the menstrual cycle. The initial rise of LH levels concomitantly occurred when serum E2 concentrations over 100 pg/ml and over 200 pg/ml were maintained for 2 approximately... |
THERE IS LITTLE IN EDWARD ALBEE'S PLAY(S) Box and Quotations from Chairman Mao Tse—Tung that obviously conforms to even an expressionistically liberal definition of "normal" drama. Such things as plot, character, setting, dramatic conflict, dialogue hardly exist in any conventional sense. In Box there is only the stark... |
BACKGROUND |
Analysis of blood samples may identify adverse drug reactions (ADRs) and risk situations. The study objective was to validate a method for in-hospital detection of ADRs based on screening of blood samples. |
MATERIAL AND METHODS |
Routine blood samples from patients in a geriatric ward were screened according to simple decision criteria to identify ADRs. The method was compared to intensive clinical monitoring of ADRs. |
RESULTS |
61 ADRs were identified in 33 patients; 11 ADRs per 1,000 bed days by the screening method (14 totally) and 37 ADRs per 1,000 bed days by intensive monitoring. The positive predictive value for the screening method was 0.29 (95% CI (0.18-0.43). |
CONCLUSION |
The screening method identified ADRs characterized by pathological laboratory values. The method should be further tested with modified decision criteria when electronic patient records, including electronic drug prescription, become routine practice in the hospital.Modulation of expression of the MHC class I‐binding n... |
The natural killer (NK) cells play an important role in viral infections via their spontaneous cytolytic activity against virus‐infected cells as well as via secreting a variety of soluble mediators. The MHC class I‐binding NK receptors of these cells have emerged as the most important regulators of the effector activi... |
My dissertation offers a critical topography in which the processes and practices of producing post-disaster spaces are exposed, which, in turn, ‘invite the vivid revelation of social and political difference and inequality’ (Katz 2001, 1228). Because space is necessarily malleable, fluid, and relational due to the eve... |
Respondent is an American importer of Russian wood products and had contracts with an American shipper for shipment of the products from the Soviet Union to American ports. The shipper in turn employed a stevedoring company to unload its ships. The stevedore's employees were members of petitioner longshoremen's union (... |
The human body contains approximately 3.2% nitrogen (N), mainly present as protein and amino acids. Although N exists at a high concentration (78%) in the air, it is not readily available to animals and most plants. Plants are however able to take up both nitrate (NO3- ) and ammonium (NH4+ ) ions from the soil and conv... |
A frame relay service offers virtual private networks to customers by provisioning a set of long-term private virtual circuits (PVCs) between customer endpoints on a large backbone network. During the provisioning of a PVC, routing decisions are made without any knowledge of future requests. Over time, these decisions ... |
Introduction: |
In addition to other disease-, patient- and procedure-related factors, recent studies revealed a strong impact of somatic mutations on the outcome after allogeneic transplantation (allo-SCT) in patients with myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (AML). The choice of pre-transplant strate... |
Methods: For this purpose we performed amplicon-based sequencing (TruSight Myeloid 54-gene panel, Illumina®) of pre-transplant samples from 128 patients with MDS (85%) or sAML (15%) who had received an allo-SCT at our institution between 2001 and 2015 from related (46%) or unrelated (54%) donors following standard-dos... |
Results: Estimated 5-year overall (OS) and relapse-free survival (RFS) of the entire cohort was 56% and 42%, respectively. Corresponding to the presence of at least one mutation in 87% of patients (median 2 mutations per patient, range 0-6) a total of 285 mutations were detected, with RUNX1 (18%), ASXL1 (17%), SRSF2 (... |
Conclusion: |
These results confirm and expand previous data on the prognostic impact of mutations in TP53, SF3B1, DNMT3A and NRAS on outcome after allo-SCT. There seems be a prognostic interaction between mutational status and pre-transplant strategy, suggesting that it may be possible to adapt pre-transplant therapy according to ... |
Figure 1 |
Rautenberg: Jazz Pharmaceuticals: Other: Travel Support; Celgene: Honoraria, Other: Travel Support. Germing:Novartis: Honoraria, Research Funding; Jazz Pharmaceuticals: Honoraria; Celgene: Honoraria, Research Funding; Amgen: Honoraria. Gattermann:Alexion: Research Funding; Novartis: Honoraria; Takeda: Research Funding... |
The Artistry of Anger: Black and White Women's Literature in America, 1820-1860, and: The Language of War: Literature and Culture in the U.S. from the Civil War through World War II (review) |
of effigies of George III in 1776. Downes suggests that because the American revolutionaries were unable to physically kill their King, they killed him metaphorically, in repeated staged performances of regicide. The meaning of this spectacle depends on a shared acknowledgement of the symbolic power vested in a materia... |
Economic theory states that incineration and landfill taxes can be a good policy to reduce environmental impacts of these activities by reducing their importance and associated pollutants, while stimulating reuse and recycling of materials. In this research we assess the economic and environmental effects of these taxe... |
ABSTRACT In this paper is presented possible application of the theory of semi-Markov processes to elaborating an eight-state model of the process of occurrence of serviceability state and unserviceability states of sea-going ships making critical manoeuvres during their entering and leaving the ports. In the analysis ... |
With the proliferation of computer security threats on the Internet, especially threats such as worms that automatically exploit software flaws, it is becoming more and more important that home users keep their computers secure from known software vulnerabilities. Unfortunately, keeping software up-to-date is notorious... |
Abstract Hip pain is a common complaint in a pediatric emergency department. The causes of hip pain are diverse and generally include traumatic and infectious causes. We report a case of hip pain caused by deep soft tissue infection associated with hypercalcemia and primary hyperparathyroidism. Atypical presentation of... |
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