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GV human oocytes were donated by consenting female patients (n = 57), 21-45-year-old undergoing IVF/ICSI. As a control, GV mouse oocytes were collected from female mice after injection of pregnant mares' serum gonadotrophin. Human and mouse GV oocytes allocated for immunocytochemistry were fixed on day of retrieval, st... |
MAIN RESULTS AND THE ROLE OF CHANCE |
GV location was peripheral and independent of age in 69.9% of the human oocytes, but GV location did vary with age in mice oocytes; it was central in 89.9% of the oocytes retrieved from young-mice and peripheral in 52.1% of the oocytes retrieved from old mice (P < 0.05). A central GV, whether in human or mouse oocytes,... |
LIMITATIONS, REASONS FOR CAUTION |
The fact that the human GV oocytes used in this study were exposed to gonadotrophic stimulation but failed to mature in vivo might be a sign of their low quality and this should be considered when drawing conclusions from the data. Furthermore, our observation that only peripheral-GV human oocytes were degraded may ind... |
WIDER IMPLICATIONS OF THE FINDINGS |
We suggest that the central location of GV within the oocytes, which is associated with an absence of Fyn at the GV and the presence of thick filamentous MTs in the ooplasm, may serve as a predictor of successful maturation and provide new insights for the use of IVM.A novel enhanced bio-inspired harmony search algorit... |
This paper presents a novel clustering algorithm based on harmony Search (HS) with features of Artificial Bee Colony (ABC) and K-means algorithms. Harmony search (HS) is a stochastic meta-heuristic optimization algorithm inspired from the improvisation process of musicians. However, HS fails to concentrate on the cruci... |
Smt3 belongs to a growing family of ubiquitin‐related proteins involved in posttranslational protein modification. Independent studies demonstrate an essential function of Smt3 in the regulation of nucleocytoplasmic transport, and suggest a role in cell‐cycle regulation. Here we report the high‐resolution NMR structure... |
Chromosomal abnormalities of intravascular large B-cell lymphoma (IVLBCL), a rare form of extranodal diffuse large B-cell lymphoma, have been described in only a small number of cases. A 59-year-old female presented with pancytopenia and splenomegaly. Bone marrow was normocellular with 30.4% abnormal large lymphoid cel... |
Milk is a part of many food products. In the expert assessment of the quality of raw materials, primary attention should be paid to its microbiological safety, since poisoning with dairy products is a common cause of diseases of the gastrointestinal tract. The experiment has been carried out on the base in the Teaching... |
Doramectin was used in a strategic programme for the prevention of parasitic gastroenteritis in first season grazing calves. Three groups of nine calves were used: group 1 was left untreated, group 2 was treated with doramectin at 0.2 mg/kg at turnout and again eight weeks later, and group 3 was treated with 0.2 mg/kg ... |
The thymus is known to be the most crucial organ in the body's immunological system. Recently, it was reported that foam cells, the hallmark of the atherosclerotic lesion, are believed to be derived from macrophages, on the basis of Fc receptor activity.' There is known to be a close relationship between lymphocytes an... |
In several computer engineering and computer science courses, it has been observed that active learning activities (ALAs) aid the students in better understanding of the technical material. In this paper, we explore the influence of the type of the ALA and the academic quality of the student on the effectiveness of the... |
During repeating sequences of low (A) and high (B) tones, perception of two separate streams ("streaming") increases with greater frequency separation (Δƒ) between the A and B tones; in contrast, a prior context with large Δƒ results in less streaming during a subsequent test pattern. The purpose of the present study w... |
Accessing vulnerable and hard-to-reach populations is a significant challenge for nurse researchers. Adaptive sampling is a procedure that has been used effectively in community-based research to recruit rare or hidden populations. Structured community assessment, as practiced by community health nurses, can be used to... |
Several histone deacetylase inhibitors (HDACi), including vorinostat, have been approved for the therapy of cutaneous T-cell lymphoma (CTCL). Emerging data suggest that HDACi may exert immune suppressive effects which would be disadvantageous for therapy of CTCL. We describe a patient with Sezary syndrome who was monit... |
Three-dimensional (3D) vision plays an important role in industrial vision, where occlusion and reflection have made it challenging to reconstruct the entire application scene. In this paper, we present a novel 3D reconstruction framework to solve the occlusion and reflection reconstruction issues in complex scenes. A ... |
During drug development, large libraries of new chemical entities (NCEs) are generated and undergo in vitro screens of metabolism and cytotoxicity. These screens are heavily relied upon to select lead compounds with the highest chance of success in pre-clinical studies and clinical trials, but suffer from limited in vi... |
It is still true that defining problems is half the way to finding a solution. In this article I aim to explain how I see the Catalan conflict and, in so doing, do my best not to turn my preferences into prejudices and try to strike a balance between the descriptions of reality that |
seem to ignore the tensions and the descriptions that excessively dramatize the differences. In a context where political agents are more interested in proving the strength of their character and their convictions than in getting results and signing agreements, I defend that there is a procedure |
for reaching a solution that should respect three principles: representation, revisability and indeterminacy.Fingers and thumbs |
1 wrote to Anaesthesia in 1978 (35 65&2) asking for any information that might be available about the interesting inhaler shown in Fig. 1. It was manufactured by Reynolds and Branson Ltd. of Leeds (now part of Barclay Hospital Ltd. of Chester). I have now discovered a reference to the device in theMedicalAnnualfor 1913... |
Novel drugs are needed to increase treatment response in children with high-risk T-cell acute lymphoblastic leukemia (T-ALL). Following up on our previous report on the activation of the MAP2K7-JNK pathway in pediatric T-ALL, we here demonstrate that OTSSP167, recently shown to inhibit MAP2K7, has anti-leukemic capacit... |
The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the production of D-2-hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels of this metabolite may play a central role in propagating... |
This cross-sectional study was performed with 160 women between 2005-2006. The objective was to describe the social-demographic and reproductive characteristics of women hospitalized due to abortions, and their knowledge about contraceptive methods and abortion induction. In order to determine the association between t... |
A European voter is a person who has their own political, social, and cultural background, while sharing a main goal with other Europeans: preserving democracy and the values and benefits that it entails. With more than 400 million people eligible to vote the result of the European elections has a great impact on Europ... |
The influence of plant material fixation methods on the index of fluctuating asymmetry of Betula pendula Roth leaves is determined. The methods used were herbarization under pressure and leaves fixation in a solution of ethyl alcohol (45%). Biological material was collected in natural phytocenoses of the Pritalskaya zo... |
How the heartland of America is to develop – not only its shape and structure but also its moral and ethical character – has yet to be decided. The land itself, however, is not silent, but ‘speaks’ of one way in which it might be fashioned. For the whole prairie is described, in a passage evocative of Exodus 3.2, as a ... |
N EWBORN humans begin life with hematocrits much higher than those of adults. Hematocrit is controlled in mammals by a negative feedback system in which tissue P02 in the kidney is used as an indicator of the oxygen-carrying capacity of the blood. The particular tissue in which erythropoietin, the hormone that stimulat... |
A 3-y-old male pigtailed macaque (Macaca nemestrina) presented for swelling of the left distal forearm and decreased use of the arm. The monkey had been raised at an indoor-outdoor facility in Arizona and transferred to an indoor facility in Washington 2 mo prior to presentation. A preliminary diagnosis of fungal osteo... |
Monoclonal antibodies raised against the nicotinic acetylcholine receptor of Electrophorus electricus electroplaque have been used as probes to characterize putative nicotinic acetylcholine receptors in goldfish brain. One monoclonal antibody (mAb), mAb 47, recognized a protein which binds both (-)-['H]nicotine and '... |
The authentic data on the drug resistance of Mycobacterium tuberculosis can be obtained only provided that standard laboratory procedures and the unified standardized method for determining the resistance are used along with a compulsory outside quality control over the performance of this test. The supervisory activit... |
In view of the problems that have not been solved or studied in the previous studies of cascade Energy Storage Operation Chart (ESOC), based on a brief description of the composition, principle, drawing methods, and simulation methods of ESOC, the following innovative work has been done in this paper. Firstly, consider... |
The RPL routing protocol has gained prominence as the standard IoT routing protocol. However, it faces like many other routing protocols diverse attacks. Many studies have been proposed to secure the RPL protocol, and simulation studies have been put forward as the main research method while testbed experiments though ... |
Various types of energy Key Performance Indicators (KPIs) are used to measure the energy efficiency performance of gas processing facilities. Establishing the appropriate energy KPI targets - long term and short term - is far more challenging than defining the KPIs itself. The objective of this paper is to discuss som... |
Subsequent to defining the energy KPIs, performance targets are required to be established to drive the energy efficiency actions. There are multiple ways to identify the energy KPI targets; some employ simplistic approaches while others involve more complex analysis and formulations. This paper describes three energy... |
The paper discusses detailed implementation steps for each of the three targeting methodologies. Field data and examples have been used to demonstrate the application of the approaches. A discussion of pros and cons has also been covered for each method. The analysis reflects that the method of utilizing historical da... |
Despite extensive efforts by oil and gas industry to improve energy efficiency performance, there is not much literature available on the subject area covered in this paper. The author recognized the need for sharing his experience for the benefit of industry.Treatment of Recurrent Malignant Gliomas With Stereotactic ... |
Malignant gliomas are usually refractory to aggressive combined-modality therapy, and the incidence of recurrence and death after treatment is very high. State-of-the-art techniques such as stereotactic intensity-modulated radiation therapy (IMRT) are now available to deliver a high dose of radiation to the tumor with ... |
Low recovery, 2 to 15%, in unconventional plays (including tight reservoirs and source rocks) has long been recognized as a business deterrent. The industry applies enhanced oil recovery (EOR) techniques, along with hydraulic fractures in tight/unconventional plays, to improve the recovery. To maximize matrix sweep, t... |
In this work, we introduce the multistage enhanced recovery (MS-ER) techniques that enable face-to-face alignment for optimal enhanced hydrocarbon recovery (EHR)/IOR/EOR in horizontal wells with multistage transverse fractures, thereby enabling optimal recovery and mitigating the key risk of fracture short-circuiting.... |
The nomenclatural types of Celastrus senegalensis Lam., basionym of the current name Maytenus senegalensis (Lam.) Exell, and C. europaeus Boiss., basionym of M. senegalensis subsp. europaea (Boiss.) Rivas Martinez ex Guemes & M.B. Crespo (Celastraceae, Celastroideae), are discussed. A specimen preserved in the herbariu... |
Bulk mRNA was used to explore the transcriptional activity of bacterial communities in oxic versus anoxic paddy soil. Two microbial cDNA libraries were constructed from composite samples using semi-randomly primed RT-PCR. cDNAs averaged 500-600 bp in length and were treated as expressed sequence tags (ESTs). Clustering... |
Deliberate self-harm by ingestion of organophosphate insecticides is a common health problem in Sri Lanka. The poisoning results in an initial life-threatening cholinergic crisis and several intermediate and late neurological and psychiatric manifestations. A patient who developed self-limiting cerebellar signs 8 days ... |
In recent past, high-repetition-rate, ultrafast pulse excitation has been identified to play an important role in stable trapping of dielectric nanoparticles assisted by optical nonlinearity due to its high peak power. We experimentally demonstrate trapping of 100-nm fluorescent polystyrene particles by simultaneous de... |
A case of chronic eosinophilic pneumonia (CEP), confirmed by transfibroptic bronchoscope lung biopsy, was reported. CEP is a chronic interstitial lung disease characterized by cough, dyspnea, malaise, fever, night sweats, weight loss, variable degree of blood eosinophilia and film revealing peripheral nonsegmental nonm... |
Genetic counselors have skills and expertise in genetics and patient care that make them an asset to research and research teams. However, the National Society of Genetic Counselors (NSGC) found in 2020 that more than half of practicing genetic counselors do not participate in research activities. Information describin... |
This paper presents a neural adaptive fault tolerant control design of wind turbines in partial load operation. The controller is designed to be robust against actuator faults as well as noise, while keeping the wind turbine generating as much power as possible. The wind speed variation is considered as an external dis... |
Among the ancients, ethics was resolved largely through the treatment of virtues. Suffice it to recall Aristotle’s Etica Nicomachea, which was for many centuries a prescribed text.’ In our times such a treatment has almost disappeared. Today moral philosophers discuss values and choices, on both analytical and proposit... |
Knowledge of the molecular background of functional magnetic resonance (MR) images is required to fully exploit their potential in cancer management. We explored the prognostic impact of dynamic contrast-enhanced MR imaging (DCE-MRI) parameters in cervical cancer combined with global gene expression data to reveal thei... |
Abstract Over the past four years, the University of Northern Iowa has gradually adopted teacher work sample methodology as a way of evaluating student teachers. In this article, the authors will draw on their experience with this implementation process to define and describe the teacher work sample as a standards‐base... |
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