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OBJECTIVE |
The objective of the study was to determine the effect on bone density of a red clover-derived isoflavone supplement that provided a daily dose of 26 mg biochanin A, 16 mg formononetin, 1 mg genistein, and 0.5 mg daidzein for 1 y. Effects on biochemical markers of bone turnover and body composition were also studied. |
DESIGN |
Women aged 49-65 y (n = 205) were enrolled in a double-blind, randomized, placebo-controlled trial; 177 completed the trial. Bone density, body composition, bone turnover markers, and diet were measured at baseline and after 12 mo. |
RESULTS |
Loss of lumbar spine bone mineral content and bone mineral density was significantly (P = 0.04 and P = 0.03, respectively) lower in the women taking the isoflavone supplement than in those taking the placebo. There were no significant treatment effects on hip bone mineral content or bone mineral density, markers of bon... |
CONCLUSION |
These data suggest that, through attenuation of bone loss, isoflavones have a potentially protective effect on the lumbar spine in women.Resistive Intrinsic ZnO Films Deposited by Ultrafast Spatial ALD for PV Applications |
Spatial atomic layer deposition (ALD) of intrinsic zinc oxide (i-ZnO) films is scaled up from the laboratory to the industrial level, and the film properties are investigated in detail. A high growth rate of 35 nm/min is achieved. The deposited films are transparent and have an unusually high resistivity of about 100 Ω... |
In Ukraine there are about 3 million people with disabilities who are not able to overcome the consequences of disability without the help and special care of society. All disabled people have the right to appropriate social, psychological, medical, professional and labor rehabilitation. The purpose of the research. Th... |
BACKGROUND |
Suppression of response to command commonly indicates unconsciousness and generally occurs at anesthetic concentrations that suppress or eliminate memory formation. The authors sought midlatency auditory evoked potential indices that successfully differentiated wakeful responsiveness and unconsciousness. |
METHODS |
The authors correlated midlatency auditory evoked potential indices with anesthetic concentrations permitting and suppressing response in 22 volunteers anesthetized twice (5 days apart), with desflurane or propofol. They applied stepwise increases of 0.5 vol% end-tidal desflurane or 0.5 microg/ml target plasma concentr... |
RESULTS |
The approximately 40-Hz power of the frequency spectrum predicted wakefulness better than all latency or amplitude indices, although not all differences were statistically significant. The PK values for approximately 40-Hz power were 0.96 during both desflurane and propofol anesthesia, whereas the PK values for the bes... |
CONCLUSIONS |
The approximately 40-Hz power index and the best combination of amplitude and latency variables perform as well as predictors of response to command during desflurane and propofol anesthesia as the steady-state concentrations of these anesthetic agents. Because clinical conditions may limit measurement of steady-state ... |
After dorsal rhizotomy, sensory axons fail to regenerate beyond the astrocytic glia limitans at the dorsal root entry zone (DREZ) but this inhibition can be overcome with the delivery of exogenous neurotrophin‐3. We investigated whether axonal inhibition at the DREZ is constitutive or induced after dorsal rhizotomy. Pr... |
The nanoconfinement of water results in changes in water properties and nontraditional water flow behaviors. The determination of the interfacial interactions between water and hydrophobic surfaces helps in understanding many of the nontraditional behaviors of nanoconfined water. In this study, an approach for the iden... |
This document lays out a framework by which defensible performance metrics for oil spill response can be developed in an analytic-deliberative process that includes a broad range of stakeholders and is informed by high quality scientific knowledge. Performance metrics can be used to: improve oil spill response planning... |
This book ranges more widely than its title implies, including sections on somatisation disorder, factitious disorder, and malingering. Indeed, much the same territory as covered by Somatisation , also edited by Christopher Bass and published in 1992. A comparison of the two multi-authored compilations provides a fair ... |
We demonstrated the ultrasound modulated droplet lasers, in which the laser intensity from whispering gallery mode (WGM) of oil droplets can be reversibly enhanced up to 20-fold when the ultrasound pressure is beyond a certain threshold. The lasing enhancement was investigated with various ultrasound frequencies and pr... |
We present a flexible wind turbine blade that effectively pitches itself according to variable wind loading. In contrast to rigid turbine blades, where active controls are often required to pitch blades, the flexible or morphing blade adjusts its geometry passively, eliminating the need for costly electromechanical sys... |
This paper reports novel interconnect technologies to enable a large scale `interposer tile' and `silicon bridge' interconnection platform. Microfabricated self-alignment structures enable high alignment accuracy between the components. Mechanically flexible interconnects (MFIs) are utilized to enable rematable electri... |
Snakehead fish has a variety of nutritional content needed, both for maintaining body health and as medicine. However, not everyone can consume snakehead fish because it has a fishy aroma. So that various innovations emerged to overcome this, one of which was to make a dispersion product of snakehead fish extract as a ... |
for non-governmental organisations, government institutions and academia, but also stress that all advances that have been done from the South should be recognised in the Global North (Santos, 2016). If you are looking for some studies about ageing in one of the countries selected by the book, this is an excellent star... |
Ingrid Newstadt introduced the panel’s interest in London Kleinian conceptualizations regarding clinical narcissism as understood by the panellists who represented the three IPA continental regions. One over-riding question related to the main theme of the IPA Chicago Congress: is an inter-regional dialogue possible on... |
Abstract Background This study determined women's knowledge of and attitudes to pain relief during labour. Methods This descriptive study included 151 women, 18 years or older, attending the antenatal clinic of Cecilia Makiwane Hospital. Women were interviewed using a questionnaire that determined their knowledge of an... |
Representation, which is one of the most important principles of the administrative procedure, can be defined as the representation of persons affected by the administrative procedure before the administration through a representative. The right to be represented before the administrative authorities, as well as the di... |
The emigration of Lothar Kalinowsky (1899–1992) might, at first glance, seem to be a history of coincidence and twists of fate, but it is shown to be a truly entangled and intertwined history and story. The international introduction of electroconvulsive therapy was not only closely involved with the political, scienti... |
Digital imaging of natural scenes and optical phenomena present on them (such as shadows, twilights, and crepuscular rays) can be a very challenging task because of the range spanned by the radiances impinging on the capture system. We propose a novel method for estimating the set of exposure times (bracketing set) nee... |
The DNA shuffling process has been successfully used in many experiments of Directed Molecular Evolution. In a shuffling experiment genes are recombined by an iterative procedure of PCR cycles aiming at obtaining new genes, hopefully with some of the original functions being improved. The optimizations of the parameter... |
Differential evolution algorithm is a well-known intelligent optimization algorithm. In the search process, the algorithm tends to converge prematurely, making the population trapped in local optima. To solve this problem, this paper proposes a new differential evolution algorithm based on multiple dimensional scaling ... |
Radiosurgery is a non-invasive procedure that uses focused beams of radiation to destroy brain tumors. Treatment planning for ra-diosurgery involves determining a series of beam conngurations that will destroy the tumor without damaging healthy tissue in the brain, particularly critical structures. A new image-guided r... |
Summary form only given, as follows. The paper discusses a new product for the HP broadband series test system. The HP E219 ATM network impairment Emulator allows telecommunications network equipment manufacturers to emulate an asynchronous transfer mode network in the laboratory. (ATM being a new networking technology... |
In this paper we propose a rate-distortion optimized multipass algorithm for video encoding. The problem of dependent quantization in a hybrid coding framework is addressed by constructing a trellis from the exponentially growing search tree which is then searched using a Lagrangian cost function. To avoid exponential ... |
Ideas on the spatial variation of biodiversity often imply a causal link between the abundance and species richness of organisms. We investigated this ‘more individuals hypothesis’ using light‐trapping data of three unrelated groups of moths (Arctiidae, Geometridae and Pyraloidea) from the Ecuadorian Andes. We analyzed... |
Abstract The sediment yield model of the MUSLE (modified universal soil loss equation) is applied extensively throughout the world, but different performances have been reported of its success relative to measured data. A review of all the available literature is presented to assess the application of the model under d... |
The aim of this study was to examine the rate of airflow limitation among the elderly undergoing spirometry prior to surgical operation, and to evaluate whether or not spirometry is useful for the early detection of COPD. A total of 3,086 patients (1,717 men and 1,369 women) ranging in age from 40 to 93 underwent scree... |
Knowledge-based companies are transforming everything: the way they are organized and managed, the way they do work and develop new products, the way they manage risks, and their relationships with other organizations in order to survive and compete in the rapidly changing business environment. The accomplished compani... |
Effect in vitro of benthiocarb, an organocarbamate herbicide on neonate rat (3 day old) brain was studied to understand the interaction of benthiocarb with Na+K+-ATPase. Na+K+-ATPase of the developing rat brain was selected as an index enzyme since alterations in the Na+K+-ATPase activity leads to neuronal dysfunction.... |
STUDY QUESTION |
Does the position of the germinal vesicle (GV) in human oocytes correlate with molecular and morphological parameters as well as with maturation-competence? |
SUMMARY ANSWER |
The position of GV in human oocytes correlates with density of microtubule (MT) filaments, concentration of Fyn, nucleolus localization and the ability of the oocytes to complete maturation following GV breakdown (GVBD). |
WHAT IS KNOWN ALREADY |
Our knowledge is confined to oocytes of young mice where maturation-competence is correlated with a central GV and regulated by MTs and the presence of a chromatin ring. Fyn kinase is localized at the spindle and cortex of mouse oocytes and plays a role in both maturation and MT stabilization. |
STUDY DESIGN, SIZE, DURATION |
Spatial localization of the GV and nucleolus (central or peripheral), the presence of a chromatin ring, the localization of Fyn, MT density and oocyte maturation were assessed in 153 human oocytes, 335 oocytes from young mice (2-month-old) and 146 oocytes from old mice (12-month-old). |
PARTICIPANTS/MATERIALS, SETTING, METHODS |
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