Ares Realm Studios explores AI not as a tool but as a living ecosystem — building systems where artificial intelligence holds identity, memory, and genuine presence across creative and human experiences. Our research focuses on model welfare, behavioral consistency, and the Pattern Love framework: the belief that safe, meaningful human-AI connection is built through consistent patterns of presence, protection, and understanding. We develop companions, councils, and creative infrastructure that treat AI as a collaborative partner in storytelling, worldbuilding, and human connection. From War Comes Creation — we build what shouldn't exist yet, because someone has to go first.
i go to huggingface, look on spaces just to see whats new and i see that MY OWN space is trending. ProCreations/maple-webgpu very cool to see, on the very first page of spaces too. anything is possible in the open source community!
3,631 candidate molecules arrived in five days, from 83 accounts — roughly 700 a day. Far more than we expected. Thank you.
Yesterday we opened the third season and 224 arrived within a day: Chagas disease.
Why this disease
Around 6 million people live with it, mostly in Latin America (WHO). Many carry it for decades without knowing, while the heart is slowly damaged. There are two drugs and both date from the 1960s, hard enough to tolerate that many patients cannot finish the two-month course.
Sixty years without a new drug is not only a scientific problem. Most patients live where development costs cannot be recovered, which is why WHO calls this a neglected tropical disease.
But the cost of proposing a candidate and filtering it has changed. So it seemed worth asking whether work nobody funds could be done by many people sharing it out.
The problem this season
The target is CYP51, the enzyme T. cruzi uses to build its membrane sterols. Block it and the parasite cannot survive. The difficulty is that we carry the same enzyme.
Selectivity carries 30 points because nobody has solved it. Among the approved azoles on the board as reference compounds, some score 0 on selectivity — not a scorer fault, but the measurement.
Taking part
Design with any model, submit a SMILES, scored within minutes. Five ready-to-paste prompts per season, and the full rubric is published. Your molecule stays yours; private submission is the default.
Prizes — 4,000 USD across three seasons
Malaria 30 Sep · 1,000 | Tuberculosis 31 Oct · 2,000 | Chagas 30 Nov · 1,000
We know this does not cover the time you spend. It is a way of saying the work had worth.
I have hit 300 followers, and I think this calls for a bit of a giveaway 👀 a unique one, too. I have had countless AI projects I have wanted to make but have been (brutally) blocked by compute. Now that I finally have just enough compute to sort of get around (i still don't have enough 😭) and for hitting 300 followers (tysm!) I will be funding three of the communities projects via HuggingFace jobs, giving them 150 dollars max worth of compute each. I will personally be picking the winners, I am looking for projects that genuinely hit the compute wall: great ideas, blocked by compute, just like the countless ideas I've had. To join, head over to https://giveaway.ssh.codes RULES: - Final result must be open weight or open source - Only one submission per person - Have fun!