metadata
license: mit
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
systemsage
Composite Systems Age integrates the 11 mortality-associated physiological-system scores plus a DNAm chronological-age prediction through PCA and Cox elastic-net regression, then rescales the result to an age-like value.
| Predicts | multisystem biological age |
| Species | Homo sapiens |
| Tissue | whole blood |
| Data type | DNA methylation |
| Model type | PCA + elastic net regression |
| Year | 2025 |
Use with pyaging
import pyaging as pya
pya.pred.predict_age(adata, ["systemsage"])
Browse every clock in the pyaging Clock Catalogue.
Citation
Sehgal, R., Markov, Y., Qin, C., et al. (2025). Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nature Aging, 5, 1880–1896.