ID
stringlengths
13
17
question
stringlengths
88
1.13k
answer
stringlengths
6
156
reference_sequence
stringlengths
4.1k
4.1k
variant_sequence
stringlengths
4.1k
4.1k
Task1_train_30000
An alteration has been detected in FGD1 (FYVE, RhoGEF and PH domain containing 1) on Chromosome X. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Aarskog syndrome
TTGACCAGCTCCACGGCCCGGTCAAAGTTCTTCACATACTCACCATACATCTTGAGGAAGGGGGCCAGTTTCTGCAGGATGTCTCCAATGCGTGGATAGCGGTCCCTGGGGTGGAATTAGGGGCTGATGTGGTCCTGCTGCTCTTTGCCCCTCAGAAACTTCCCCCACAAGTTTCCAGCCCCAGGCAGATACCTTTCATCTCAGTCCTAGAAACCTACTTCTCAGCTAGTCTGCTCCTTCAGAAATGCTGCTTACATTACAGGCCAGTGAGGCCAAGAGGCTCGGCTTGACTTCAGACCACAGCCTGGGATGCCACCTGC...
TTGACCAGCTCCACGGCCCGGTCAAAGTTCTTCACATACTCACCATACATCTTGAGGAAGGGGGCCAGTTTCTGCAGGATGTCTCCAATGCGTGGATAGCGGTCCCTGGGGTGGAATTAGGGGCTGATGTGGTCCTGCTGCTCTTTGCCCCTCAGAAACTTCCCCCACAAGTTTCCAGCCCCAGGCAGATACCTTTCATCTCAGTCCTAGAAACCTACTTCTCAGCTAGTCTGCTCCTTCAGAAATGCTGCTTACATTACAGGCCAGTGAGGCCAAGAGGCTCGGCTTGACTTCAGACCACAGCCTGGGATGCCACCTGC...
Task1_train_30001
A variant affecting Chromosome X, within the gene FGD1 (FYVE, RhoGEF and PH domain containing 1), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Neurodevelopmental delay
TGACCAGCTCCACGGCCCGGTCAAAGTTCTTCACATACTCACCATACATCTTGAGGAAGGGGGCCAGTTTCTGCAGGATGTCTCCAATGCGTGGATAGCGGTCCCTGGGGTGGAATTAGGGGCTGATGTGGTCCTGCTGCTCTTTGCCCCTCAGAAACTTCCCCCACAAGTTTCCAGCCCCAGGCAGATACCTTTCATCTCAGTCCTAGAAACCTACTTCTCAGCTAGTCTGCTCCTTCAGAAATGCTGCTTACATTACAGGCCAGTGAGGCCAAGAGGCTCGGCTTGACTTCAGACCACAGCCTGGGATGCCACCTGCC...
TGACCAGCTCCACGGCCCGGTCAAAGTTCTTCACATACTCACCATACATCTTGAGGAAGGGGGCCAGTTTCTGCAGGATGTCTCCAATGCGTGGATAGCGGTCCCTGGGGTGGAATTAGGGGCTGATGTGGTCCTGCTGCTCTTTGCCCCTCAGAAACTTCCCCCACAAGTTTCCAGCCCCAGGCAGATACCTTTCATCTCAGTCCTAGAAACCTACTTCTCAGCTAGTCTGCTCCTTCAGAAATGCTGCTTACATTACAGGCCAGTGAGGCCAAGAGGCTCGGCTTGACTTCAGACCACAGCCTGGGATGCCACCTGCC...
Task1_train_30002
Given this context: Chromosome X, gene FGD1 (FYVE, RhoGEF and PH domain containing 1) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; not provided
CTGGGGTGGAATTAGGGGCTGATGTGGTCCTGCTGCTCTTTGCCCCTCAGAAACTTCCCCCACAAGTTTCCAGCCCCAGGCAGATACCTTTCATCTCAGTCCTAGAAACCTACTTCTCAGCTAGTCTGCTCCTTCAGAAATGCTGCTTACATTACAGGCCAGTGAGGCCAAGAGGCTCGGCTTGACTTCAGACCACAGCCTGGGATGCCACCTGCCTCAATTCTGCCCTGCCCGAGTACTGGTTGAAGTACTCACCCTGAGACCTTACTGCCAGGACCACTTCATATACTGATTATCAACTGTGTGCTGGGTGATGCTGG...
CTGGGGTGGAATTAGGGGCTGATGTGGTCCTGCTGCTCTTTGCCCCTCAGAAACTTCCCCCACAAGTTTCCAGCCCCAGGCAGATACCTTTCATCTCAGTCCTAGAAACCTACTTCTCAGCTAGTCTGCTCCTTCAGAAATGCTGCTTACATTACAGGCCAGTGAGGCCAAGAGGCTCGGCTTGACTTCAGACCACAGCCTGGGATGCCACCTGCCTCAATTCTGCCCTGCCCGAGTACTGGTTGAAGTACTCACCCTGAGACCTTACTGCCAGGACCACTTCATATACTGATTATCAACTGTGTGCTGGGTGATGCTGG...
Task1_train_30003
With a mutation on Chromosome X in gene ALAS2 (5'-aminolevulinate synthase 2), classify this variant as benign or pathogenic. Include the disease if it's pathogenic.
Pathogenic; X-linked sideroblastic anemia 1
AGGCCAAGACTTCAGAAGCCAAAGATGAGAAGGAGTTACGGACCTCATTCTGGAAGTCTGTGCTGGCGGGGCCCTTGCGCACACCCCTCTGTGGGGGCCACAGGGAGCCATGTGTGATGCGTACTGTGAAGAAGCCAGGACCCAACTTGGGCCGCCGCTTCTACATGTGTGCCAGGCCCCGGGGTCCTCCCACTGACCCCTCCTCCCGGTGCAACTTCTTCCTCTGGAGCAGGCCCAGCTGAACCAATGGAGGCCTGGGGACATCTGGCATGGTCACCCCTGCACATGATCTGAGGCCAGCTCCCCTTCCCTGAGCTGCC...
AGGCCAAGACTTCAGAAGCCAAAGATGAGAAGGAGTTACGGACCTCATTCTGGAAGTCTGTGCTGGCGGGGCCCTTGCGCACACCCCTCTGTGGGGGCCACAGGGAGCCATGTGTGATGCGTACTGTGAAGAAGCCAGGACCCAACTTGGGCCGCCGCTTCTACATGTGTGCCAGGCCCCGGGGTCCTCCCACTGACCCCTCCTCCCGGTGCAACTTCTTCCTCTGGAGCAGGCCCAGCTGAACCAATGGAGGCCTGGGGACATCTGGCATGGTCACCCCTGCACATGATCTGAGGCCAGCTCCCCTTCCCTGAGCTGCC...
Task1_train_30004
The gene ALAS2 (5'-aminolevulinate synthase 2) on Chromosome X contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; not provided
CCAAGACTTCAGAAGCCAAAGATGAGAAGGAGTTACGGACCTCATTCTGGAAGTCTGTGCTGGCGGGGCCCTTGCGCACACCCCTCTGTGGGGGCCACAGGGAGCCATGTGTGATGCGTACTGTGAAGAAGCCAGGACCCAACTTGGGCCGCCGCTTCTACATGTGTGCCAGGCCCCGGGGTCCTCCCACTGACCCCTCCTCCCGGTGCAACTTCTTCCTCTGGAGCAGGCCCAGCTGAACCAATGGAGGCCTGGGGACATCTGGCATGGTCACCCCTGCACATGATCTGAGGCCAGCTCCCCTTCCCTGAGCTGCCTCC...
CCAAGACTTCAGAAGCCAAAGATGAGAAGGAGTTACGGACCTCATTCTGGAAGTCTGTGCTGGCGGGGCCCTTGCGCACACCCCTCTGTGGGGGCCACAGGGAGCCATGTGTGATGCGTACTGTGAAGAAGCCAGGACCCAACTTGGGCCGCCGCTTCTACATGTGTGCCAGGCCCCGGGGTCCTCCCACTGACCCCTCCTCCCGGTGCAACTTCTTCCTCTGGAGCAGGCCCAGCTGAACCAATGGAGGCCTGGGGACATCTGGCATGGTCACCCCTGCACATGATCTGAGGCCAGCTCCCCTTCCCTGAGCTGCCTCC...
Task1_train_30005
This variant impacts the gene ALAS2 (5'-aminolevulinate synthase 2) on Chromosome X. Is the change likely to result in a pathogenic outcome?
Pathogenic; X-linked sideroblastic anemia 1
GAGCAATATAGTCAGAATTTTAGAAAAATCCCTCTAGTGGTCATCATCGAGAAAGGATTTGAGAGGAGCAAGAGAGAAGCAGAGAAATTAGGAAAAAAATCATGTTGACATGGATTAAAGAAGTGGCAGGGGAGAAAAGCAAATAGGTTTGAGAGAGATTATAGATAACTTTTGCAGGATTTCAGGATGGATTGGCTATGGAACTTAGGGACTGGTGGAGCCATCGTGGATGCCTCATATATTCTTACAAAAGCCTAGCCTAGGTGGACATTCAGAGAACCAAGAATACTGAGAGCTCTACAATTGAAGCCCAGAGCAAA...
GAGCAATATAGTCAGAATTTTAGAAAAATCCCTCTAGTGGTCATCATCGAGAAAGGATTTGAGAGGAGCAAGAGAGAAGCAGAGAAATTAGGAAAAAAATCATGTTGACATGGATTAAAGAAGTGGCAGGGGAGAAAAGCAAATAGGTTTGAGAGAGATTATAGATAACTTTTGCAGGATTTCAGGATGGATTGGCTATGGAACTTAGGGACTGGTGGAGCCATCGTGGATGCCTCATATATTCTTACAAAAGCCTAGCCTAGGTGGACATTCAGAGAACCAAGAATACTGAGAGCTCTACAATTGAAGCCCAGAGCAAA...
Task1_train_30006
This variant affects the gene ALAS2 (5'-aminolevulinate synthase 2) found on Chromosome X. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; X-linked sideroblastic anemia 1
CCAGGACCCGGGAGGCAGAGGTAGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCTACAGAGCCAGACTCTGTCTCAAAAAAACAAAAACAAAAACAAACAAACAAAAACAAAACTACCCAACAGAAATCCAACAAACATTAGGTGAATTGACTAAACTGGCATTTTCAGGGTAAATCTCAAACTACTCAGCTCTACAAGCCTCTCAATCCAGTCTCTATCTCATGTTGTCTTTGTAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTC...
CCAGGACCCGGGAGGCAGAGGTAGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCTACAGAGCCAGACTCTGTCTCAAAAAAACAAAAACAAAAACAAACAAACAAAAACAAAACTACCCAACAGAAATCCAACAAACATTAGGTGAATTGACTAAACTGGCATTTTCAGGGTAAATCTCAAACTACTCAGCTCTACAAGCCTCTCAATCCAGTCTCTATCTCATGTTGTCTTTGTAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTC...
Task1_train_30007
Gene ALAS2 (5'-aminolevulinate synthase 2) on Chromosome X is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; not provided
AGACTCTGTCTCAAAAAAACAAAAACAAAAACAAACAAACAAAAACAAAACTACCCAACAGAAATCCAACAAACATTAGGTGAATTGACTAAACTGGCATTTTCAGGGTAAATCTCAAACTACTCAGCTCTACAAGCCTCTCAATCCAGTCTCTATCTCATGTTGTCTTTGTAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTCTTGATATATCCCTGGCTGCTTCTCATTCTCCTCACCTATCTTCATGCTCTTCCCTCTGGTAGGAATACTTCT...
AGACTCTGTCTCAAAAAAACAAAAACAAAAACAAACAAACAAAAACAAAACTACCCAACAGAAATCCAACAAACATTAGGTGAATTGACTAAACTGGCATTTTCAGGGTAAATCTCAAACTACTCAGCTCTACAAGCCTCTCAATCCAGTCTCTATCTCATGTTGTCTTTGTAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTCTTGATATATCCCTGGCTGCTTCTCATTCTCCTCACCTATCTTCATGCTCTTCCCTCTGGTAGGAATACTTCT...
Task1_train_30008
A mutation in ALAS2 (5'-aminolevulinate synthase 2), located on Chromosome X, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; not provided
GACTCTGTCTCAAAAAAACAAAAACAAAAACAAACAAACAAAAACAAAACTACCCAACAGAAATCCAACAAACATTAGGTGAATTGACTAAACTGGCATTTTCAGGGTAAATCTCAAACTACTCAGCTCTACAAGCCTCTCAATCCAGTCTCTATCTCATGTTGTCTTTGTAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTCTTGATATATCCCTGGCTGCTTCTCATTCTCCTCACCTATCTTCATGCTCTTCCCTCTGGTAGGAATACTTCTT...
GACTCTGTCTCAAAAAAACAAAAACAAAAACAAACAAACAAAAACAAAACTACCCAACAGAAATCCAACAAACATTAGGTGAATTGACTAAACTGGCATTTTCAGGGTAAATCTCAAACTACTCAGCTCTACAAGCCTCTCAATCCAGTCTCTATCTCATGTTGTCTTTGTAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTCTTGATATATCCCTGGCTGCTTCTCATTCTCCTCACCTATCTTCATGCTCTTCCCTCTGGTAGGAATACTTCTT...
Task1_train_30009
The following genetic variant occurs in ALAS2 (5'-aminolevulinate synthase 2) on Chromosome X. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; not provided
GACTCTGTCTCAAAAAAACAAAAACAAAAACAAACAAACAAAAACAAAACTACCCAACAGAAATCCAACAAACATTAGGTGAATTGACTAAACTGGCATTTTCAGGGTAAATCTCAAACTACTCAGCTCTACAAGCCTCTCAATCCAGTCTCTATCTCATGTTGTCTTTGTAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTCTTGATATATCCCTGGCTGCTTCTCATTCTCCTCACCTATCTTCATGCTCTTCCCTCTGGTAGGAATACTTCTT...
GACTCTGTCTCAAAAAAACAAAAACAAAAACAAACAAACAAAAACAAAACTACCCAACAGAAATCCAACAAACATTAGGTGAATTGACTAAACTGGCATTTTCAGGGTAAATCTCAAACTACTCAGCTCTACAAGCCTCTCAATCCAGTCTCTATCTCATGTTGTCTTTGTAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTCTTGATATATCCCTGGCTGCTTCTCATTCTCCTCACCTATCTTCATGCTCTTCCCTCTGGTAGGAATACTTCTT...
Task1_train_30010
This is a variant in ALAS2 (5'-aminolevulinate synthase 2), located on Chromosome X. Is this mutation a likely cause of disease or not?
Pathogenic; not provided
CAGCTCTACAAGCCTCTCAATCCAGTCTCTATCTCATGTTGTCTTTGTAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTCTTGATATATCCCTGGCTGCTTCTCATTCTCCTCACCTATCTTCATGCTCTTCCCTCTGGTAGGAATACTTCTTCCATGCCCTCTTTCTTTTAATACCACTCACTTTGCAAGACTCAGCTCAGGTGTCACCTCTACTAGGAAGTGGGTCTTGCATCCCTCAGGCTGAGTCAGGCCCCTCCTCTCTGCTCCGACAACT...
CAGCTCTACAAGCCTCTCAATCCAGTCTCTATCTCATGTTGTCTTTGTAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTCTTGATATATCCCTGGCTGCTTCTCATTCTCCTCACCTATCTTCATGCTCTTCCCTCTGGTAGGAATACTTCTTCCATGCCCTCTTTCTTTTAATACCACTCACTTTGCAAGACTCAGCTCAGGTGTCACCTCTACTAGGAAGTGGGTCTTGCATCCCTCAGGCTGAGTCAGGCCCCTCCTCTCTGCTCCGACAACT...
Task1_train_30011
A change on Chromosome X affects gene ALAS2 (5'-aminolevulinate synthase 2). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; X-linked sideroblastic anemia 1
TAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTCTTGATATATCCCTGGCTGCTTCTCATTCTCCTCACCTATCTTCATGCTCTTCCCTCTGGTAGGAATACTTCTTCCATGCCCTCTTTCTTTTAATACCACTCACTTTGCAAGACTCAGCTCAGGTGTCACCTCTACTAGGAAGTGGGTCTTGCATCCCTCAGGCTGAGTCAGGCCCCTCCTCTCTGCTCCGACAACTCTATCATGCACTGCCTTGTGGAGCTTTGATCATCCCTTAGTGTCATT...
TAGACTCATAGATTGATACTCCCCTGCCCCACTCCATTCCTATGACCCTACATTCCAATACCACCTGCTTATTGTTCTTGATATATCCCTGGCTGCTTCTCATTCTCCTCACCTATCTTCATGCTCTTCCCTCTGGTAGGAATACTTCTTCCATGCCCTCTTTCTTTTAATACCACTCACTTTGCAAGACTCAGCTCAGGTGTCACCTCTACTAGGAAGTGGGTCTTGCATCCCTCAGGCTGAGTCAGGCCCCTCCTCTCTGCTCCGACAACTCTATCATGCACTGCCTTGTGGAGCTTTGATCATCCCTTAGTGTCATT...
Task1_train_30012
Here is a variant affecting ALAS2 (5'-aminolevulinate synthase 2) on Chromosome X. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; X-linked sideroblastic anemia 1
GCGCAGGAGCTCTTCACCCCGGGGGACAGTTGGGTAGTTGATGGCCTGCACATAGATGCCATGCTTGGAGAGCAGGAGATCACAGAGCTTGCTGTTGAGTGCTGCATTGCCCACCTGGACTCAGGAGAAAGGCTAATCAGTACCTGCCACTCTGGCTCCACCATCACTAGCTCCATTAAGCAGATGGAGGGAACTAGATGAGGGAACATCACTGAATTTTGGGATAGATTTTTTTTTTCCATTAGGGGCTTAGTGGCAGCTCCAGAATTTCTATCAAGGAGGAGCTCAGAGCTAGCAATTTGGTTTGAAAAGGATGGAGC...
GCGCAGGAGCTCTTCACCCCGGGGGACAGTTGGGTAGTTGATGGCCTGCACATAGATGCCATGCTTGGAGAGCAGGAGATCACAGAGCTTGCTGTTGAGTGCTGCATTGCCCACCTGGACTCAGGAGAAAGGCTAATCAGTACCTGCCACTCTGGCTCCACCATCACTAGCTCCATTAAGCAGATGGAGGGAACTAGATGAGGGAACATCACTGAATTTTGGGATAGATTTTTTTTTTCCATTAGGGGCTTAGTGGCAGCTCCAGAATTTCTATCAAGGAGGAGCTCAGAGCTAGCAATTTGGTTTGAAAAGGATGGAGC...
Task1_train_30013
Here is a genetic alteration in ALAS2 (5'-aminolevulinate synthase 2) on Chromosome X. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Sideroblastic anemia 1, late-onset
GGTATATAAGAAGGCCCAAAGCATTCACTTACCAAGAGTTCCAGAGATGATGTCAATCTTATGCATAATTCCATCACGCTCCCCAATCCCAGCGCCCCGGGACCCATACAGTCCTACAGCATGGACCTCATCCACGAAGGTCAGGGCCCCATACTGGTGGGACACATCACACAACTCCTCGAGGGGACAGATGGCACCTGAGCAAAGCCAAGGGATAGAGGTAGGACATCATAACCCTTCCCCAGCTCCATCTCCAATGTGGAATTTCCCATACATGCCTACTTTGGGTTGGAAAAGGGTGTTGTAGAGAGGAAGGAGGA...
GGTATATAAGAAGGCCCAAAGCATTCACTTACCAAGAGTTCCAGAGATGATGTCAATCTTATGCATAATTCCATCACGCTCCCCAATCCCAGCGCCCCGGGACCCATACAGTCCTACAGCATGGACCTCATCCACGAAGGTCAGGGCCCCATACTGGTGGGACACATCACACAACTCCTCGAGGGGACAGATGGCACCTGAGCAAAGCCAAGGGATAGAGGTAGGACATCATAACCCTTCCCCAGCTCCATCTCCAATGTGGAATTTCCCATACATGCCTACTTTGGGTTGGAAAAGGGTGTTGTAGAGAGGAAGGAGGA...
Task1_train_30014
A variant has been detected on Chromosome X in ALAS2 (5'-aminolevulinate synthase 2). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; X-linked sideroblastic anemia 1
TCACTTACCAAGAGTTCCAGAGATGATGTCAATCTTATGCATAATTCCATCACGCTCCCCAATCCCAGCGCCCCGGGACCCATACAGTCCTACAGCATGGACCTCATCCACGAAGGTCAGGGCCCCATACTGGTGGGACACATCACACAACTCCTCGAGGGGACAGATGGCACCTGAGCAAAGCCAAGGGATAGAGGTAGGACATCATAACCCTTCCCCAGCTCCATCTCCAATGTGGAATTTCCCATACATGCCTACTTTGGGTTGGAAAAGGGTGTTGTAGAGAGGAAGGAGGATGTGCGCCTTCATTTAGAACTATT...
TCACTTACCAAGAGTTCCAGAGATGATGTCAATCTTATGCATAATTCCATCACGCTCCCCAATCCCAGCGCCCCGGGACCCATACAGTCCTACAGCATGGACCTCATCCACGAAGGTCAGGGCCCCATACTGGTGGGACACATCACACAACTCCTCGAGGGGACAGATGGCACCTGAGCAAAGCCAAGGGATAGAGGTAGGACATCATAACCCTTCCCCAGCTCCATCTCCAATGTGGAATTTCCCATACATGCCTACTTTGGGTTGGAAAAGGGTGTTGTAGAGAGGAAGGAGGATGTGCGCCTTCATTTAGAACTATT...
Task1_train_30015
A variant found in Chromosome X affects ALAS2 (5'-aminolevulinate synthase 2). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; not provided
CTGAAGAATCAGCAGGAGGTGAGGAAGTAGATAGTAAGAGCGAAGACTTCTCTCAAGCAGTTTGCCTGTTATAGGGAGGAAAGAGGGCAGTAGCTAGAGAGTGATCAGGGGTTGAGGCAATGTTTTTTTATAAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAG...
CTGAAGAATCAGCAGGAGGTGAGGAAGTAGATAGTAAGAGCGAAGACTTCTCTCAAGCAGTTTGCCTGTTATAGGGAGGAAAGAGGGCAGTAGCTAGAGAGTGATCAGGGGTTGAGGCAATGTTTTTTTATAAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAG...
Task1_train_30016
A variant found in Chromosome X affects ALAS2 (5'-aminolevulinate synthase 2). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; X-linked sideroblastic anemia 1
GCAGGAGGTGAGGAAGTAGATAGTAAGAGCGAAGACTTCTCTCAAGCAGTTTGCCTGTTATAGGGAGGAAAGAGGGCAGTAGCTAGAGAGTGATCAGGGGTTGAGGCAATGTTTTTTTATAAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGA...
GCAGGAGGTGAGGAAGTAGATAGTAAGAGCGAAGACTTCTCTCAAGCAGTTTGCCTGTTATAGGGAGGAAAGAGGGCAGTAGCTAGAGAGTGATCAGGGGTTGAGGCAATGTTTTTTTATAAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGA...
Task1_train_30017
Chromosome X houses a mutation in gene ALAS2 (5'-aminolevulinate synthase 2). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; X-linked sideroblastic anemia 1
GAGCGAAGACTTCTCTCAAGCAGTTTGCCTGTTATAGGGAGGAAAGAGGGCAGTAGCTAGAGAGTGATCAGGGGTTGAGGCAATGTTTTTTTATAAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGAAGATGCTTATGAGTTTGTAGGTGCTT...
GAGCGAAGACTTCTCTCAAGCAGTTTGCCTGTTATAGGGAGGAAAGAGGGCAGTAGCTAGAGAGTGATCAGGGGTTGAGGCAATGTTTTTTTATAAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGAAGATGCTTATGAGTTTGTAGGTGCTT...
Task1_train_30018
Here is a variant affecting ALAS2 (5'-aminolevulinate synthase 2) on Chromosome X. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; X-linked sideroblastic anemia 1
GAGTGATCAGGGGTTGAGGCAATGTTTTTTTATAAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGAAGATGCTTATGAGTTTGTAGGTGCTTTGTGGCTGGGAGTCAAGGACATTGCTGTCTGGTATCTTCTATTTTGAATGTAGTAGAACAT...
GAGTGATCAGGGGTTGAGGCAATGTTTTTTTATAAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGAAGATGCTTATGAGTTTGTAGGTGCTTTGTGGCTGGGAGTCAAGGACATTGCTGTCTGGTATCTTCTATTTTGAATGTAGTAGAACAT...
Task1_train_30019
An alteration has been detected in ALAS2 (5'-aminolevulinate synthase 2) on Chromosome X. Is it pathogenic, and if so, what disease is involved?
Pathogenic; not provided
TTGAGGCAATGTTTTTTTATAAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGAAGATGCTTATGAGTTTGTAGGTGCTTTGTGGCTGGGAGTCAAGGACATTGCTGTCTGGTATCTTCTATTTTGAATGTAGTAGAACATGAAGTTGTCTGCT...
TTGAGGCAATGTTTTTTTATAAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGAAGATGCTTATGAGTTTGTAGGTGCTTTGTGGCTGGGAGTCAAGGACATTGCTGTCTGGTATCTTCTATTTTGAATGTAGTAGAACATGAAGTTGTCTGCT...
Task1_train_30020
Given this variant in gene ALAS2 (5'-aminolevulinate synthase 2) on Chromosome X, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; X-linked sideroblastic anemia 1
AAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGAAGATGCTTATGAGTTTGTAGGTGCTTTGTGGCTGGGAGTCAAGGACATTGCTGTCTGGTATCTTCTATTTTGAATGTAGTAGAACATGAAGTTGTCTGCTGAGGGAGATGGGGAGGAGGG...
AAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGAAGATGCTTATGAGTTTGTAGGTGCTTTGTGGCTGGGAGTCAAGGACATTGCTGTCTGGTATCTTCTATTTTGAATGTAGTAGAACATGAAGTTGTCTGCTGAGGGAGATGGGGAGGAGGG...
Task1_train_30021
The gene ALAS2 (5'-aminolevulinate synthase 2), on Chromosome X, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; X-linked sideroblastic anemia 1
AAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGAAGATGCTTATGAGTTTGTAGGTGCTTTGTGGCTGGGAGTCAAGGACATTGCTGTCTGGTATCTTCTATTTTGAATGTAGTAGAACATGAAGTTGTCTGCTGAGGGAGATGGGGAGGAGGG...
AAGATACAAGAGACTTGAAAACATGTTTAAAGAGAGGGAGAGGCTGAAGATACAGGAGAGGAGGAGAGAGCCAATAGGTCAAGATTCCTAAGGTGGTAGAGGGGAATGGGGCACAGAGCAACAGTGGAAGGATTAGTCACAAGAAAAAGGATACTTCTTCCACTATGACAGAAGAGAAGGAGTGAGGAGAGGACATTTGAAGATGCTTATGAGTTTGTAGGTGCTTTGTGGCTGGGAGTCAAGGACATTGCTGTCTGGTATCTTCTATTTTGAATGTAGTAGAACATGAAGTTGTCTGCTGAGGGAGATGGGGAGGAGGG...
Task1_train_30022
This sequence variant lies in UBQLN2 (ubiquilin 2) on Chromosome X. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Amyotrophic lateral sclerosis type 15
AATTAATCATCCTTTTTTAATGTCTATTGGCCATTTGCACTCCTTTTGTAAAATGCACGCTCCTGCTCTGTCTTCTTCCCTTCCCCTACTGGAGGTGTTCCTCTTTTCTTTTTGCTTTGTCAGAGTTCTTTATTATTCATTTTTCGTCTTATACGTGGGATCTGTTCGATTCAGGCTTTCACCCTTTTACTGCCTTACAGATTGCTAATATACATTCTCCATTGGTCTTTTAATGTCGTTTACAGAAGCTGACTCTCTACCGCCTCCTTCTCTCCGTCTCACCCTCTCTGCCTCGCCTGCTCTGTACTGTTCTGTTCTCT...
AATTAATCATCCTTTTTTAATGTCTATTGGCCATTTGCACTCCTTTTGTAAAATGCACGCTCCTGCTCTGTCTTCTTCCCTTCCCCTACTGGAGGTGTTCCTCTTTTCTTTTTGCTTTGTCAGAGTTCTTTATTATTCATTTTTCGTCTTATACGTGGGATCTGTTCGATTCAGGCTTTCACCCTTTTACTGCCTTACAGATTGCTAATATACATTCTCCATTGGTCTTTTAATGTCGTTTACAGAAGCTGACTCTCTACCGCCTCCTTCTCTCCGTCTCACCCTCTCTGCCTCGCCTGCTCTGTACTGTTCTGTTCTCT...
Task1_train_30023
A variant has been detected on Chromosome X in UBQLN2 (ubiquilin 2). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Amyotrophic lateral sclerosis type 15
TCTCCATTGGTCTTTTAATGTCGTTTACAGAAGCTGACTCTCTACCGCCTCCTTCTCTCCGTCTCACCCTCTCTGCCTCGCCTGCTCTGTACTGTTCTGTTCTCTTCTCTCTCTCCCTTTGTTTCTCTCTCTCCCTTTTTTCTTTTCAGTGCAGAAGTTTTTAATTTTGACCGAGCCAAATCTATCAATCTAGGCCTGGCGCCGCGTCAGCAGAGGGGGCGGGGAGGCGAGCGCGGAACTGGGGGAGGGGAAGGGGCGGGGATCAGCAGGCGGAGCGGCTGCCAGAGTTGCTGGGAGTGCGCGCGGTCGGATCACAAGGC...
TCTCCATTGGTCTTTTAATGTCGTTTACAGAAGCTGACTCTCTACCGCCTCCTTCTCTCCGTCTCACCCTCTCTGCCTCGCCTGCTCTGTACTGTTCTGTTCTCTTCTCTCTCTCCCTTTGTTTCTCTCTCTCCCTTTTTTCTTTTCAGTGCAGAAGTTTTTAATTTTGACCGAGCCAAATCTATCAATCTAGGCCTGGCGCCGCGTCAGCAGAGGGGGCGGGGAGGCGAGCGCGGAACTGGGGGAGGGGAAGGGGCGGGGATCAGCAGGCGGAGCGGCTGCCAGAGTTGCTGGGAGTGCGCGCGGTCGGATCACAAGGC...
Task1_train_30024
This mutation is located in gene UBQLN2 (ubiquilin 2) on Chromosome X. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Amyotrophic lateral sclerosis type 15
CTCCATTGGTCTTTTAATGTCGTTTACAGAAGCTGACTCTCTACCGCCTCCTTCTCTCCGTCTCACCCTCTCTGCCTCGCCTGCTCTGTACTGTTCTGTTCTCTTCTCTCTCTCCCTTTGTTTCTCTCTCTCCCTTTTTTCTTTTCAGTGCAGAAGTTTTTAATTTTGACCGAGCCAAATCTATCAATCTAGGCCTGGCGCCGCGTCAGCAGAGGGGGCGGGGAGGCGAGCGCGGAACTGGGGGAGGGGAAGGGGCGGGGATCAGCAGGCGGAGCGGCTGCCAGAGTTGCTGGGAGTGCGCGCGGTCGGATCACAAGGCG...
CTCCATTGGTCTTTTAATGTCGTTTACAGAAGCTGACTCTCTACCGCCTCCTTCTCTCCGTCTCACCCTCTCTGCCTCGCCTGCTCTGTACTGTTCTGTTCTCTTCTCTCTCTCCCTTTGTTTCTCTCTCTCCCTTTTTTCTTTTCAGTGCAGAAGTTTTTAATTTTGACCGAGCCAAATCTATCAATCTAGGCCTGGCGCCGCGTCAGCAGAGGGGGCGGGGAGGCGAGCGCGGAACTGGGGGAGGGGAAGGGGCGGGGATCAGCAGGCGGAGCGGCTGCCAGAGTTGCTGGGAGTGCGCGCGGTCGGATCACAAGGCG...
Task1_train_30025
This mutation is located in gene UBQLN2 (ubiquilin 2) on Chromosome X. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Amyotrophic lateral sclerosis type 15
CAGAAGCTGACTCTCTACCGCCTCCTTCTCTCCGTCTCACCCTCTCTGCCTCGCCTGCTCTGTACTGTTCTGTTCTCTTCTCTCTCTCCCTTTGTTTCTCTCTCTCCCTTTTTTCTTTTCAGTGCAGAAGTTTTTAATTTTGACCGAGCCAAATCTATCAATCTAGGCCTGGCGCCGCGTCAGCAGAGGGGGCGGGGAGGCGAGCGCGGAACTGGGGGAGGGGAAGGGGCGGGGATCAGCAGGCGGAGCGGCTGCCAGAGTTGCTGGGAGTGCGCGCGGTCGGATCACAAGGCGGCGGCGGAGGAGGCCCAGAGACCGGA...
CAGAAGCTGACTCTCTACCGCCTCCTTCTCTCCGTCTCACCCTCTCTGCCTCGCCTGCTCTGTACTGTTCTGTTCTCTTCTCTCTCTCCCTTTGTTTCTCTCTCTCCCTTTTTTCTTTTCAGTGCAGAAGTTTTTAATTTTGACCGAGCCAAATCTATCAATCTAGGCCTGGCGCCGCGTCAGCAGAGGGGGCGGGGAGGCGAGCGCGGAACTGGGGGAGGGGAAGGGGCGGGGATCAGCAGGCGGAGCGGCTGCCAGAGTTGCTGGGAGTGCGCGCGGTCGGATCACAAGGCGGCGGCGGAGGAGGCCCAGAGACCGGA...
Task1_train_30026
Here is a variant affecting ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9) on Chromosome X. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Developmental and epileptic encephalopathy, 8
AGGAACACTCCTCCCGGCCTTGGACTTAGGGGCATTAATGGCTGCCCACTGATATTCTGAAGTCTGGCTCTGTCATTTGCTTCCCTGAGCCATCCTGGCTTGCTCAATCATTTCCCCCCATCCTTGGATTTACTATTTATTATAAAAGTAACATTTCCTTGAAAATGAAATGCATTTGGATTTGGGTGACATCATCATTTGGTACAGTTTAATCCTTCTTTTAAAGAGGGAGGTCTGTAAGCACAAGACATACCAGCTGTATGCGTACAGGGCCTCACATTAGTCCTGAAGGTCTGTGGTTATTGATACGCTTTTTCTGA...
AGGAACACTCCTCCCGGCCTTGGACTTAGGGGCATTAATGGCTGCCCACTGATATTCTGAAGTCTGGCTCTGTCATTTGCTTCCCTGAGCCATCCTGGCTTGCTCAATCATTTCCCCCCATCCTTGGATTTACTATTTATTATAAAAGTAACATTTCCTTGAAAATGAAATGCATTTGGATTTGGGTGACATCATCATTTGGTACAGTTTAATCCTTCTTTTAAAGAGGGAGGTCTGTAAGCACAAGACATACCAGCTGTATGCGTACAGGGCCTCACATTAGTCCTGAAGGTCTGTGGTTATTGATACGCTTTTTCTGA...
Task1_train_30027
Mutation context: Chromosome X, Gene ZC4H2 (zinc finger C4H2-type containing). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Wieacker-Wolff syndrome
CTCACATTGTTCACAATCCCATGAAATAAGTGCTAATATTTTCCCCATTTTCCAGATGAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAG...
CTCACATTGTTCACAATCCCATGAAATAAGTGCTAATATTTTCCCCATTTTCCAGATGAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAG...
Task1_train_30028
Given this variant in gene ZC4H2 (zinc finger C4H2-type containing) on Chromosome X, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Inborn genetic diseases
CAATCCCATGAAATAAGTGCTAATATTTTCCCCATTTTCCAGATGAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATC...
CAATCCCATGAAATAAGTGCTAATATTTTCCCCATTTTCCAGATGAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATC...
Task1_train_30029
Assess the clinical impact of this variant on gene ZC4H2 (zinc finger C4H2-type containing), found on Chromosome X. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; not provided
AAATAAGTGCTAATATTTTCCCCATTTTCCAGATGAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATCCTGCAATTTC...
AAATAAGTGCTAATATTTTCCCCATTTTCCAGATGAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATCCTGCAATTTC...
Task1_train_30030
A change on Chromosome X affects gene ZC4H2 (zinc finger C4H2-type containing). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Wieacker-Wolff syndrome
CAGATGAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATCCTGCAATTTCCTCTTACTAGCTGTTTAACTCTGAAAAAG...
CAGATGAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATCCTGCAATTTCCTCTTACTAGCTGTTTAACTCTGAAAAAG...
Task1_train_30031
Gene ZC4H2 (zinc finger C4H2-type containing) on Chromosome X is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Wieacker-Wolff syndrome
GAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATCCTGCAATTTCCTCTTACTAGCTGTTTAACTCTGAAAAAGCTTTT...
GAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATCCTGCAATTTCCTCTTACTAGCTGTTTAACTCTGAAAAAGCTTTT...
Task1_train_30032
A mutation on Chromosome X affecting ZC4H2 (zinc finger C4H2-type containing) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; Wieacker-Wolff syndrome, female-restricted
GAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATCCTGCAATTTCCTCTTACTAGCTGTTTAACTCTGAAAAAGCTTTT...
GAGGACACTGAGGCACAGAGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATCCTGCAATTTCCTCTTACTAGCTGTTTAACTCTGAAAAAGCTTTT...
Task1_train_30033
A variant on Chromosome X in gene ZC4H2 (zinc finger C4H2-type containing) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Wieacker-Wolff syndrome, female-restricted
AGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATCCTGCAATTTCCTCTTACTAGCTGTTTAACTCTGAAAAAGCTTTTAAGTTTTTGGAGGTTCAG...
AGAGGTTTTATTTAGCTGTTGAATTCCCTGACAAGCACAGAGACAGATTAGTGTACAGGATATTATTTAGAGAGCCCTTGGCCTTTATATCCCTGAATCAGTCATTTGACACCCAGTTCTTGATTTCAGTTCCAAAGTTATTTCAACCACTCTCATCATCAAGCCATTCTGAAAGGGAGAAAGGTTTTCTTAAAAATGATCATGGAGAAGAAGTAGAAAAAAATGAGCTCTGGAGTTGGACAAAGCTGGCTCCAAATCCTGCAATTTCCTCTTACTAGCTGTTTAACTCTGAAAAAGCTTTTAAGTTTTTGGAGGTTCAG...
Task1_train_30034
The variant affects gene ZC4H2 (zinc finger C4H2-type containing), which is on Chromosome X. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Wieacker-Wolff syndrome
CAATATCACACAAAGAATTTAAAAAGCCACCTAGTAGTTGTTCTAATTCATCTAGTAATTCATCCAGTTTAATAATCCTCCTTCTGTTTTAACAAGCTGGCACAGAGACTTGCCCAAGATCACACAGTGAGTAAGCCACTGAAAGGCCTGGGACTAAAACTAGGCACTCTGACTTTCAGGCTAGGCTTTGTGTATGTATACCTGCCCGTGTGTGTGTAGGTATGTAAGTATGTATGTGGGTCGGAGGGAGGGTATGTTGTAGGGACTGGGGGCAGGTAGCTTACTCCAAGGAAAGCTTCTCCTCTTCTTCACACAAGTCA...
CAATATCACACAAAGAATTTAAAAAGCCACCTAGTAGTTGTTCTAATTCATCTAGTAATTCATCCAGTTTAATAATCCTCCTTCTGTTTTAACAAGCTGGCACAGAGACTTGCCCAAGATCACACAGTGAGTAAGCCACTGAAAGGCCTGGGACTAAAACTAGGCACTCTGACTTTCAGGCTAGGCTTTGTGTATGTATACCTGCCCGTGTGTGTGTAGGTATGTAAGTATGTATGTGGGTCGGAGGGAGGGTATGTTGTAGGGACTGGGGGCAGGTAGCTTACTCCAAGGAAAGCTTCTCCTCTTCTTCACACAAGTCA...
Task1_train_30035
This alteration in ZC4H2 (zinc finger C4H2-type containing) on Chromosome X may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Wieacker-Wolff syndrome
CAAAGAATTTAAAAAGCCACCTAGTAGTTGTTCTAATTCATCTAGTAATTCATCCAGTTTAATAATCCTCCTTCTGTTTTAACAAGCTGGCACAGAGACTTGCCCAAGATCACACAGTGAGTAAGCCACTGAAAGGCCTGGGACTAAAACTAGGCACTCTGACTTTCAGGCTAGGCTTTGTGTATGTATACCTGCCCGTGTGTGTGTAGGTATGTAAGTATGTATGTGGGTCGGAGGGAGGGTATGTTGTAGGGACTGGGGGCAGGTAGCTTACTCCAAGGAAAGCTTCTCCTCTTCTTCACACAAGTCAGGGAGCCTCT...
CAAAGAATTTAAAAAGCCACCTAGTAGTTGTTCTAATTCATCTAGTAATTCATCCAGTTTAATAATCCTCCTTCTGTTTTAACAAGCTGGCACAGAGACTTGCCCAAGATCACACAGTGAGTAAGCCACTGAAAGGCCTGGGACTAAAACTAGGCACTCTGACTTTCAGGCTAGGCTTTGTGTATGTATACCTGCCCGTGTGTGTGTAGGTATGTAAGTATGTATGTGGGTCGGAGGGAGGGTATGTTGTAGGGACTGGGGGCAGGTAGCTTACTCCAAGGAAAGCTTCTCCTCTTCTTCACACAAGTCAGGGAGCCTCT...
Task1_train_30036
Given this variant in gene ZC4H2 (zinc finger C4H2-type containing) on Chromosome X, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Wieacker-Wolff syndrome
TTTCTTTGTTGAGACTTTCTATTCATTTTCTGAGATTTTCTACATTATCATTTGTTTCAAGTGTATTGTAACTGCTCACTGAAATGTTTTTAGGACAGGTGCTTTAAGATCCTTATCAGATAATTCTAACATGGGTGTTATCTCAGTATTGGCATCTGTTTATTTTCTCTTCTCATTCAAGTGGATATCTTAGTATGGAAAGTGATTTTTGATTAAAAGTTGGATACTCTGGATCTTATTTAAATCTTTTGTTTTAGCAGTCCTCTACCACTCTCTTGGATGGAAGAGGGACAGTAGAAGTCCAGTTTCTCCACTGTCTC...
TTTCTTTGTTGAGACTTTCTATTCATTTTCTGAGATTTTCTACATTATCATTTGTTTCAAGTGTATTGTAACTGCTCACTGAAATGTTTTTAGGACAGGTGCTTTAAGATCCTTATCAGATAATTCTAACATGGGTGTTATCTCAGTATTGGCATCTGTTTATTTTCTCTTCTCATTCAAGTGGATATCTTAGTATGGAAAGTGATTTTTGATTAAAAGTTGGATACTCTGGATCTTATTTAAATCTTTTGTTTTAGCAGTCCTCTACCACTCTCTTGGATGGAAGAGGGACAGTAGAAGTCCAGTTTCTCCACTGTCTC...
Task1_train_30037
This variant affects gene ZC4H2 (zinc finger C4H2-type containing) located on Chromosome X. Evaluate its biological effect and specify any disease association.
Pathogenic; not provided
TTGTTTCAAGTGTATTGTAACTGCTCACTGAAATGTTTTTAGGACAGGTGCTTTAAGATCCTTATCAGATAATTCTAACATGGGTGTTATCTCAGTATTGGCATCTGTTTATTTTCTCTTCTCATTCAAGTGGATATCTTAGTATGGAAAGTGATTTTTGATTAAAAGTTGGATACTCTGGATCTTATTTAAATCTTTTGTTTTAGCAGTCCTCTACCACTCTCTTGGATGGAAGAGGGACAGTAGAAGTCCAGTTTCTCCACTGTCTCTTGACATCCAGTTTGGAGAAGGGCTGTTTGTTACTGCTGTTTAGAGGTGAA...
TTGTTTCAAGTGTATTGTAACTGCTCACTGAAATGTTTTTAGGACAGGTGCTTTAAGATCCTTATCAGATAATTCTAACATGGGTGTTATCTCAGTATTGGCATCTGTTTATTTTCTCTTCTCATTCAAGTGGATATCTTAGTATGGAAAGTGATTTTTGATTAAAAGTTGGATACTCTGGATCTTATTTAAATCTTTTGTTTTAGCAGTCCTCTACCACTCTCTTGGATGGAAGAGGGACAGTAGAAGTCCAGTTTCTCCACTGTCTCTTGACATCCAGTTTGGAGAAGGGCTGTTTGTTACTGCTGTTTAGAGGTGAA...
Task1_train_30038
This gene mutation involves LAS1L (LAS1 like ribosome biogenesis factor) on Chromosome X. Is it associated with any clinical condition, or is it benign?
Pathogenic; Wilson-Turner syndrome
CTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGACCAGGCCGGCTGCAGTGGCTTATACCTGTGATCCCAGCACTTTGGGAGGCCAAGGCAGGACAATCTCTTGAATCCCAAAACTTGAAACCAGCCTGGGCAACATGGTGAGACCCCATCTCTACAAAAAATTATAAAATTAGCCAGACATGGTAGTGCATGCCTGTTGGTCCTAGCTACTTAGGAGGCTGAGGTGGGAGGATTTCTTGAGTGTGCGAGGTTGAGGCTGTAGTTAACTATGTTCGCACCACTGCACTCCAGCCTGGGTGACAGAGC...
CTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGACCAGGCCGGCTGCAGTGGCTTATACCTGTGATCCCAGCACTTTGGGAGGCCAAGGCAGGACAATCTCTTGAATCCCAAAACTTGAAACCAGCCTGGGCAACATGGTGAGACCCCATCTCTACAAAAAATTATAAAATTAGCCAGACATGGTAGTGCATGCCTGTTGGTCCTAGCTACTTAGGAGGCTGAGGTGGGAGGATTTCTTGAGTGTGCGAGGTTGAGGCTGTAGTTAACTATGTTCGCACCACTGCACTCCAGCCTGGGTGACAGAGC...
Task1_train_30039
This sequence change occurs on Chromosome X, altering MSN (moesin). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; Combined immunodeficiency due to moesin deficiency
ACTTATAAGACGAGCTTAAAAGAAGAGCTTATGCCTACTATCAGAATTTGGGGATAGTTGGATATAGTCAGATAAAAGTGGTTTGAAGATTTCTGATCATCAGTCGGTATTAAGGTAATTTCAGGAAGAAATTCCCAACAGAAAGTGATTACAGACATGGGATTCAGTCCCCAGTGAAAGTAATGTATTATTTTTCTTAATTACCAGGGGAGTTGCCACCCAGCTGTCTAAGATTATGCAAATTGATGATCTTTCAGTGTTTTCTCCCCACCCTACAGCCACTCCATTACCCTTAAAACCTATTTTTTGAGAGTCCATAA...
ACTTATAAGACGAGCTTAAAAGAAGAGCTTATGCCTACTATCAGAATTTGGGGATAGTTGGATATAGTCAGATAAAAGTGGTTTGAAGATTTCTGATCATCAGTCGGTATTAAGGTAATTTCAGGAAGAAATTCCCAACAGAAAGTGATTACAGACATGGGATTCAGTCCCCAGTGAAAGTAATGTATTATTTTTCTTAATTACCAGGGGAGTTGCCACCCAGCTGTCTAAGATTATGCAAATTGATGATCTTTCAGTGTTTTCTCCCCACCCTACAGCCACTCCATTACCCTTAAAACCTATTTTTTGAGAGTCCATAA...
Task1_train_30040
This sequence variant lies in AR (androgen receptor) on Chromosome X. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Partial androgen insensitivity syndrome
TCCTCCACAAAAGAGCAGTTGCAGTAACCCACATCATCCTCTACGCCTGGCTGTCCATCAAGAGGCGAAAAGCAGCCCTATATAGGTTCTATCCTTGGATAGTTCCAGTTGTAAAGTTTAAAATATGCGAAGGCAACTTGGAAAAGCAAGCGGCTGCATACAAAGCAAACGTTTACAGAGCTCTGGACAAAATTGAGCGCCTATGTGTACATGGCAAGTGTTTTTAGTGTTTGTGTGTTTACCTGCTTGTCTGGGTGATTTTGCCTTTGAGAGTCTGGATGAGAAATGCATGGTTAAAGGCAATTCCAGACAGGAAGAAA...
TCCTCCACAAAAGAGCAGTTGCAGTAACCCACATCATCCTCTACGCCTGGCTGTCCATCAAGAGGCGAAAAGCAGCCCTATATAGGTTCTATCCTTGGATAGTTCCAGTTGTAAAGTTTAAAATATGCGAAGGCAACTTGGAAAAGCAAGCGGCTGCATACAAAGCAAACGTTTACAGAGCTCTGGACAAAATTGAGCGCCTATGTGTACATGGCAAGTGTTTTTAGTGTTTGTGTGTTTACCTGCTTGTCTGGGTGATTTTGCCTTTGAGAGTCTGGATGAGAAATGCATGGTTAAAGGCAATTCCAGACAGGAAGAAA...
Task1_train_30041
A variant was discovered in gene AR (androgen receptor), Chromosome X. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Male infertility
TTGTAGGAGACTCTCCCACTCTCCCATCTGCGCGCTCTTATCAGTCCTGAAAAGAACCCCTGGCAGCCAGGAGCAGGTATTCCTATCGTCCTTTTCCTCCCTCCCTCGCCTCCACCCTGTTGGTTTTTTAGATTGGGCTTTGGAACCAAATTTGGTGAGTGCTGGCCTCCAGGAAATCTGGAGCCCTGGCGCCTAAACCTTGGTTTAGGAAAGCAGGAGCTATTCAGGAAGCAGGGGTCCTCCAGGGCTAGAGCTAGCCTCTCCTGCCCTCGCCCACGCTGCGCCAGCACTTGTTTCTCCAAAGCCACTAGGCAGGCGTT...
TTGTAGGAGACTCTCCCACTCTCCCATCTGCGCGCTCTTATCAGTCCTGAAAAGAACCCCTGGCAGCCAGGAGCAGGTATTCCTATCGTCCTTTTCCTCCCTCCCTCGCCTCCACCCTGTTGGTTTTTTAGATTGGGCTTTGGAACCAAATTTGGTGAGTGCTGGCCTCCAGGAAATCTGGAGCCCTGGCGCCTAAACCTTGGTTTAGGAAAGCAGGAGCTATTCAGGAAGCAGGGGTCCTCCAGGGCTAGAGCTAGCCTCTCCTGCCCTCGCCCACGCTGCGCCAGCACTTGTTTCTCCAAAGCCACTAGGCAGGCGTT...
Task1_train_30042
This mutation is located in gene AR (androgen receptor) on Chromosome X. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; not specified
TTGTAGGAGACTCTCCCACTCTCCCATCTGCGCGCTCTTATCAGTCCTGAAAAGAACCCCTGGCAGCCAGGAGCAGGTATTCCTATCGTCCTTTTCCTCCCTCCCTCGCCTCCACCCTGTTGGTTTTTTAGATTGGGCTTTGGAACCAAATTTGGTGAGTGCTGGCCTCCAGGAAATCTGGAGCCCTGGCGCCTAAACCTTGGTTTAGGAAAGCAGGAGCTATTCAGGAAGCAGGGGTCCTCCAGGGCTAGAGCTAGCCTCTCCTGCCCTCGCCCACGCTGCGCCAGCACTTGTTTCTCCAAAGCCACTAGGCAGGCGTT...
TTGTAGGAGACTCTCCCACTCTCCCATCTGCGCGCTCTTATCAGTCCTGAAAAGAACCCCTGGCAGCCAGGAGCAGGTATTCCTATCGTCCTTTTCCTCCCTCCCTCGCCTCCACCCTGTTGGTTTTTTAGATTGGGCTTTGGAACCAAATTTGGTGAGTGCTGGCCTCCAGGAAATCTGGAGCCCTGGCGCCTAAACCTTGGTTTAGGAAAGCAGGAGCTATTCAGGAAGCAGGGGTCCTCCAGGGCTAGAGCTAGCCTCTCCTGCCCTCGCCCACGCTGCGCCAGCACTTGTTTCTCCAAAGCCACTAGGCAGGCGTT...
Task1_train_30043
Given this context: Chromosome X, gene AR (androgen receptor) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; Kennedy disease
TTGTAGGAGACTCTCCCACTCTCCCATCTGCGCGCTCTTATCAGTCCTGAAAAGAACCCCTGGCAGCCAGGAGCAGGTATTCCTATCGTCCTTTTCCTCCCTCCCTCGCCTCCACCCTGTTGGTTTTTTAGATTGGGCTTTGGAACCAAATTTGGTGAGTGCTGGCCTCCAGGAAATCTGGAGCCCTGGCGCCTAAACCTTGGTTTAGGAAAGCAGGAGCTATTCAGGAAGCAGGGGTCCTCCAGGGCTAGAGCTAGCCTCTCCTGCCCTCGCCCACGCTGCGCCAGCACTTGTTTCTCCAAAGCCACTAGGCAGGCGTT...
TTGTAGGAGACTCTCCCACTCTCCCATCTGCGCGCTCTTATCAGTCCTGAAAAGAACCCCTGGCAGCCAGGAGCAGGTATTCCTATCGTCCTTTTCCTCCCTCCCTCGCCTCCACCCTGTTGGTTTTTTAGATTGGGCTTTGGAACCAAATTTGGTGAGTGCTGGCCTCCAGGAAATCTGGAGCCCTGGCGCCTAAACCTTGGTTTAGGAAAGCAGGAGCTATTCAGGAAGCAGGGGTCCTCCAGGGCTAGAGCTAGCCTCTCCTGCCCTCGCCCACGCTGCGCCAGCACTTGTTTCTCCAAAGCCACTAGGCAGGCGTT...
Task1_train_30044
Chromosome X houses a mutation in gene AR (androgen receptor). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Androgen resistance syndrome
TTGTAGGAGACTCTCCCACTCTCCCATCTGCGCGCTCTTATCAGTCCTGAAAAGAACCCCTGGCAGCCAGGAGCAGGTATTCCTATCGTCCTTTTCCTCCCTCCCTCGCCTCCACCCTGTTGGTTTTTTAGATTGGGCTTTGGAACCAAATTTGGTGAGTGCTGGCCTCCAGGAAATCTGGAGCCCTGGCGCCTAAACCTTGGTTTAGGAAAGCAGGAGCTATTCAGGAAGCAGGGGTCCTCCAGGGCTAGAGCTAGCCTCTCCTGCCCTCGCCCACGCTGCGCCAGCACTTGTTTCTCCAAAGCCACTAGGCAGGCGTT...
TTGTAGGAGACTCTCCCACTCTCCCATCTGCGCGCTCTTATCAGTCCTGAAAAGAACCCCTGGCAGCCAGGAGCAGGTATTCCTATCGTCCTTTTCCTCCCTCCCTCGCCTCCACCCTGTTGGTTTTTTAGATTGGGCTTTGGAACCAAATTTGGTGAGTGCTGGCCTCCAGGAAATCTGGAGCCCTGGCGCCTAAACCTTGGTTTAGGAAAGCAGGAGCTATTCAGGAAGCAGGGGTCCTCCAGGGCTAGAGCTAGCCTCTCCTGCCCTCGCCCACGCTGCGCCAGCACTTGTTTCTCCAAAGCCACTAGGCAGGCGTT...
Task1_train_30045
A variant on Chromosome X in gene AR (androgen receptor) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Androgen resistance syndrome
CTCGCCCACGCTGCGCCAGCACTTGTTTCTCCAAAGCCACTAGGCAGGCGTTAGCGCGCGGTGAGGGGAGGGGAGAAAAGGAAAGGGGAGGGGAGGGAAAAGGAGGTGGGAAGGCAAGGAGGCCGGCCCGGTGGGGGCGGGACCCGACTCGCAAACTGTTGCATTTGCTCTCCACCTCCCAGCGCCCCCTCCGAGATCCCGGGGAGCCAGCTTGCTGGGAGAGCGGGACGGTCCGGAGCAAGCCCAGAGGCAGAGGAGGCGACAGAGGGAAAAAGGGCCGAGCTAGCCGCTCCAGTGCTGTACAGGAGCCGAAGGGACGC...
CTCGCCCACGCTGCGCCAGCACTTGTTTCTCCAAAGCCACTAGGCAGGCGTTAGCGCGCGGTGAGGGGAGGGGAGAAAAGGAAAGGGGAGGGGAGGGAAAAGGAGGTGGGAAGGCAAGGAGGCCGGCCCGGTGGGGGCGGGACCCGACTCGCAAACTGTTGCATTTGCTCTCCACCTCCCAGCGCCCCCTCCGAGATCCCGGGGAGCCAGCTTGCTGGGAGAGCGGGACGGTCCGGAGCAAGCCCAGAGGCAGAGGAGGCGACAGAGGGAAAAAGGGCCGAGCTAGCCGCTCCAGTGCTGTACAGGAGCCGAAGGGACGC...
Task1_train_30046
Assess the clinical impact of this variant on gene AR (androgen receptor), found on Chromosome X. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Androgen resistance syndrome
ACCACGCCAGCCCCAGCCCGGCTCCAGCGACAGCCAACGCCTCTTGCAGCGCGGCGGCTTCGAAGCCGCCGCCCGGAGCTGCCCTTTCCTCTTCGGTGAAGTTTTTAAAAGCTGCTAAAGACTCGGAGGAAGCAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTG...
ACCACGCCAGCCCCAGCCCGGCTCCAGCGACAGCCAACGCCTCTTGCAGCGCGGCGGCTTCGAAGCCGCCGCCCGGAGCTGCCCTTTCCTCTTCGGTGAAGTTTTTAAAAGCTGCTAAAGACTCGGAGGAAGCAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTG...
Task1_train_30047
An alteration has been detected in AR (androgen receptor) on Chromosome X. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Kennedy disease
ACCACGCCAGCCCCAGCCCGGCTCCAGCGACAGCCAACGCCTCTTGCAGCGCGGCGGCTTCGAAGCCGCCGCCCGGAGCTGCCCTTTCCTCTTCGGTGAAGTTTTTAAAAGCTGCTAAAGACTCGGAGGAAGCAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTG...
ACCACGCCAGCCCCAGCCCGGCTCCAGCGACAGCCAACGCCTCTTGCAGCGCGGCGGCTTCGAAGCCGCCGCCCGGAGCTGCCCTTTCCTCTTCGGTGAAGTTTTTAAAAGCTGCTAAAGACTCGGAGGAAGCAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTG...
Task1_train_30048
A genomic change on Chromosome X affects AR (androgen receptor). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Malignant tumor of prostate
ACCACGCCAGCCCCAGCCCGGCTCCAGCGACAGCCAACGCCTCTTGCAGCGCGGCGGCTTCGAAGCCGCCGCCCGGAGCTGCCCTTTCCTCTTCGGTGAAGTTTTTAAAAGCTGCTAAAGACTCGGAGGAAGCAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTG...
ACCACGCCAGCCCCAGCCCGGCTCCAGCGACAGCCAACGCCTCTTGCAGCGCGGCGGCTTCGAAGCCGCCGCCCGGAGCTGCCCTTTCCTCTTCGGTGAAGTTTTTAAAAGCTGCTAAAGACTCGGAGGAAGCAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTG...
Task1_train_30049
The gene AR (androgen receptor) is located on Chromosome X, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Malignant tumor of prostate
TGCTAAAGACTCGGAGGAAGCAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTGCCAGCCCGAGTTTGCAGAGAGGTAACTCCCTTTGGCTGCGAGCGGGCGAGCTAGCTGCACATTGCAAAGAAGGCTCTTAGGAGCCAGGCGACTGGGGAGCGGCTTCAGCACT...
TGCTAAAGACTCGGAGGAAGCAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTGCCAGCCCGAGTTTGCAGAGAGGTAACTCCCTTTGGCTGCGAGCGGGCGAGCTAGCTGCACATTGCAAAGAAGGCTCTTAGGAGCCAGGCGACTGGGGAGCGGCTTCAGCACT...
Task1_train_30050
Gene AR (androgen receptor) on Chromosome X is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; not specified
TGCTAAAGACTCGGAGGAAGCAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTGCCAGCCCGAGTTTGCAGAGAGGTAACTCCCTTTGGCTGCGAGCGGGCGAGCTAGCTGCACATTGCAAAGAAGGCTCTTAGGAGCCAGGCGACTGGGGAGCGGCTTCAGCACT...
TGCTAAAGACTCGGAGGAAGCAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTGCCAGCCCGAGTTTGCAGAGAGGTAACTCCCTTTGGCTGCGAGCGGGCGAGCTAGCTGCACATTGCAAAGAAGGCTCTTAGGAGCCAGGCGACTGGGGAGCGGCTTCAGCACT...
Task1_train_30051
This genomic variant is located on Chromosome X, within the AR (androgen receptor) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Malignant tumor of prostate
CAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTGCCAGCCCGAGTTTGCAGAGAGGTAACTCCCTTTGGCTGCGAGCGGGCGAGCTAGCTGCACATTGCAAAGAAGGCTCTTAGGAGCCAGGCGACTGGGGAGCGGCTTCAGCACTGCAGCCACGACCCGCCTGGT...
CAAGGAAAGTGCCTGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTGCCAGCCCGAGTTTGCAGAGAGGTAACTCCCTTTGGCTGCGAGCGGGCGAGCTAGCTGCACATTGCAAAGAAGGCTCTTAGGAGCCAGGCGACTGGGGAGCGGCTTCAGCACTGCAGCCACGACCCGCCTGGT...
Task1_train_30052
This sequence change occurs on Chromosome X, altering AR (androgen receptor). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; Malignant tumor of prostate
TGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTGCCAGCCCGAGTTTGCAGAGAGGTAACTCCCTTTGGCTGCGAGCGGGCGAGCTAGCTGCACATTGCAAAGAAGGCTCTTAGGAGCCAGGCGACTGGGGAGCGGCTTCAGCACTGCAGCCACGACCCGCCTGGTTAGGCTGCACGCG...
TGGTAGGACTGACGGCTGCCTTTGTCCTCCTCCTCTCCACCCCGCCTCCCCCCACCCTGCCTTCCCCCCCTCCCCCGTCTTCTCTCCCGCAGCTGCCTCAGTCGGCTACTCTCAGCCAACCCCCCTCACCACCCTTCTCCCCACCCGCCCCCCCGCCCCCGTCGGCCCAGCGCTGCCAGCCCGAGTTTGCAGAGAGGTAACTCCCTTTGGCTGCGAGCGGGCGAGCTAGCTGCACATTGCAAAGAAGGCTCTTAGGAGCCAGGCGACTGGGGAGCGGCTTCAGCACTGCAGCCACGACCCGCCTGGTTAGGCTGCACGCG...
Task1_train_30053
A variant has been detected on Chromosome X in AR (androgen receptor). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Androgen resistance syndrome
GCATCAGTTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGA...
GCATCAGTTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGA...
Task1_train_30054
Here is a mutation in AR (androgen receptor) on Chromosome X. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Kennedy disease
GCATCAGTTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGA...
GCATCAGTTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGA...
Task1_train_30055
A mutation on Chromosome X affecting AR (androgen receptor) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; Prostate cancer, hereditary, X-linked 3
GCATCAGTTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGA...
GCATCAGTTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGA...
Task1_train_30056
The following genetic variant occurs in AR (androgen receptor) on Chromosome X. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; not specified
CATCAGTTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAA...
CATCAGTTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAA...
Task1_train_30057
The gene AR (androgen receptor) is located on Chromosome X, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Androgen resistance syndrome
TTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGC...
TTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGC...
Task1_train_30058
An alteration has been detected in AR (androgen receptor) on Chromosome X. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Kennedy disease
TTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGC...
TTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGC...
Task1_train_30059
This gene mutation involves AR (androgen receptor) on Chromosome X. Is it associated with any clinical condition, or is it benign?
Pathogenic; Malignant tumor of prostate
TTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGC...
TTTCCTCTTCTGCAATATAGGGATGATACACAGCTACCTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGC...
Task1_train_30060
This sequence change occurs on Chromosome X, altering AR (androgen receptor). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; Androgen resistance syndrome
CTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGCTCCTTCCATGTGGAACTTATGGCCTTGCTAGCCTTGG...
CTGGTAGGTTGTTGGGAAAATTAAATGGGATGATATGTATGAAATGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGCTCCTTCCATGTGGAACTTATGGCCTTGCTAGCCTTGG...
Task1_train_30061
A mutation found in AR (androgen receptor) on Chromosome X may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Androgen resistance syndrome
TGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGCTCCTTCCATGTGGAACTTATGGCCTTGCTAGCCTTGGTTTGTTGGAAGTGCTCTTGCTGGCTTTCTAGTTAGGGTAGGGAA...
TGGCCTGGCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGCTCCTTCCATGTGGAACTTATGGCCTTGCTAGCCTTGGTTTGTTGGAAGTGCTCTTGCTGGCTTTCTAGTTAGGGTAGGGAA...
Task1_train_30062
Gene AR (androgen receptor) on Chromosome X is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Androgen resistance syndrome
GCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGCTCCTTCCATGTGGAACTTATGGCCTTGCTAGCCTTGGTTTGTTGGAAGTGCTCTTGCTGGCTTTCTAGTTAGGGTAGGGAAAGGAAGG...
GCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGCTCCTTCCATGTGGAACTTATGGCCTTGCTAGCCTTGGTTTGTTGGAAGTGCTCTTGCTGGCTTTCTAGTTAGGGTAGGGAAAGGAAGG...
Task1_train_30063
Assess the clinical impact of this variant on gene AR (androgen receptor), found on Chromosome X. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Androgen resistance syndrome
GCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGCTCCTTCCATGTGGAACTTATGGCCTTGCTAGCCTTGGTTTGTTGGAAGTGCTCTTGCTGGCTTTCTAGTTAGGGTAGGGAAAGGAAGG...
GCATATAGAGTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGCTCCTTCCATGTGGAACTTATGGCCTTGCTAGCCTTGGTTTGTTGGAAGTGCTCTTGCTGGCTTTCTAGTTAGGGTAGGGAAAGGAAGG...
Task1_train_30064
The gene AR (androgen receptor) on Chromosome X carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Androgen resistance syndrome
GTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGCTCCTTCCATGTGGAACTTATGGCCTTGCTAGCCTTGGTTTGTTGGAAGTGCTCTTGCTGGCTTTCTAGTTAGGGTAGGGAAAGGAAGGCTTGTGGGG...
GTGCCTAAATACATGTTCTTCTGATTCTATTTGGACAGTTTGTGTTAGTAACAGAAGTCAAAAAGGTGGAGAAAGGAGAAAGGTACTTGTGAAAATTTTCTATTTCTTCTCCATGTTTCATTCAGGACTGAGGAAGGGGGCACAGTTTTTACCCAAGGAAATGACATTTTTAGCCAAAAGAAATGATCTTAGCATTTAGCTGAATTATATATTGGAAGTAAGCTCCTTCCATGTGGAACTTATGGCCTTGCTAGCCTTGGTTTGTTGGAAGTGCTCTTGCTGGCTTTCTAGTTAGGGTAGGGAAAGGAAGGCTTGTGGGG...
Task1_train_30065
The gene AR (androgen receptor) on Chromosome X contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Partial androgen insensitivity syndrome
TAGAACTATTATGGGAGCCATATTCCATTGGTGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATAT...
TAGAACTATTATGGGAGCCATATTCCATTGGTGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATAT...
Task1_train_30066
Here is a variant affecting AR (androgen receptor) on Chromosome X. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Androgen resistance syndrome
GGAGCCATATTCCATTGGTGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGT...
GGAGCCATATTCCATTGGTGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGT...
Task1_train_30067
A mutation in AR (androgen receptor), located on Chromosome X, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Partial androgen insensitivity syndrome
TGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGC...
TGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGC...
Task1_train_30068
Gene AR (androgen receptor) on Chromosome X is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Kennedy disease
TGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGC...
TGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGC...
Task1_train_30069
The following genetic variant occurs in AR (androgen receptor) on Chromosome X. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Androgen resistance syndrome
TGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGC...
TGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGC...
Task1_train_30070
Here is a mutation in AR (androgen receptor) on Chromosome X. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Disorder of sexual differentiation
TGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGC...
TGGTGCAACCATTTCTTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGC...
Task1_train_30071
Consider this mutation in AR (androgen receptor) on Chromosome X. Is this a benign change or a disease-causing variant?
Pathogenic; not provided
TTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATG...
TTGACAAACTAGGGTCCAAGAAAGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATG...
Task1_train_30072
This sequence variant lies in AR (androgen receptor) on Chromosome X. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Androgen insensitivity, partial, with breast cancer
AGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATGTGTTCTATTTATGCAAATAAAA...
AGTATTTTCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATGTGTTCTATTTATGCAAATAAAA...
Task1_train_30073
This variant lies on Chromosome X and affects the gene AR (androgen receptor). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; not provided
TCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATGTGTTCTATTTATGCAAATAAAATCTTGTG...
TCCTGGGGAAGATGAGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATGTGTTCTATTTATGCAAATAAAATCTTGTG...
Task1_train_30074
The following genetic variant occurs in AR (androgen receptor) on Chromosome X. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Partial androgen insensitivity syndrome
AGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATGTGTTCTATTTATGCAAATAAAATCTTGTGGTATGCTAGAAAGA...
AGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATGTGTTCTATTTATGCAAATAAAATCTTGTGGTATGCTAGAAAGA...
Task1_train_30075
This is a variant in AR (androgen receptor), located on Chromosome X. Is this mutation a likely cause of disease or not?
Pathogenic; Androgen resistance syndrome
AGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATGTGTTCTATTTATGCAAATAAAATCTTGTGGTATGCTAGAAAGA...
AGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATGTGTTCTATTTATGCAAATAAAATCTTGTGGTATGCTAGAAAGA...
Task1_train_30076
Mutation context: Chromosome X, Gene AR (androgen receptor). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Kennedy disease
AGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATGTGTTCTATTTATGCAAATAAAATCTTGTGGTATGCTAGAAAGA...
AGATTTCTCAAAGAAGGCACGCACTTTCTAACCTAAGCTTATTTCAGTAATCAATGTAACAAGCTGGTCTTGATGATTGCAGCAGTACCAATACTGTGGGAGTGTACCAGTTCTAGAACAGCTACAACATTGGAATTGAACGCACTAGAATTGGATACAGGACCTGTTTTTGAGGAGCTAACACCCAAAGGCTGAACAGCACTCGTAGCACCGTCCTTTCTGTGCACATATGGTAGTCCTCAGTTTGCAACAGAAATAAAGCTGTTAGCAAATTATGTGTTCTATTTATGCAAATAAAATCTTGTGGTATGCTAGAAAGA...
Task1_train_30077
A variant has been detected on Chromosome X in AR (androgen receptor). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Prostate cancer, somatic
TGCTCCATGGGCGTGGGACCCTCCGAGCCAGGTGTGGGATATAATCTCCTGGTGTGCCGTTTGCTAAGACCATTGGAAAAGTGCAGTATTAGGGTGGGAGTGACCCAATTTTCCAGGTGCCATCTGTCACAGCTTTGCTTGGCTAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCAC...
TGCTCCATGGGCGTGGGACCCTCCGAGCCAGGTGTGGGATATAATCTCCTGGTGTGCCGTTTGCTAAGACCATTGGAAAAGTGCAGTATTAGGGTGGGAGTGACCCAATTTTCCAGGTGCCATCTGTCACAGCTTTGCTTGGCTAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCAC...
Task1_train_30078
Here’s a variant in AR (androgen receptor) located on Chromosome X. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Androgen resistance syndrome
AGGGTGGGAGTGACCCAATTTTCCAGGTGCCATCTGTCACAGCTTTGCTTGGCTAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAAT...
AGGGTGGGAGTGACCCAATTTTCCAGGTGCCATCTGTCACAGCTTTGCTTGGCTAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAAT...
Task1_train_30079
This variant affects gene AR (androgen receptor) located on Chromosome X. Evaluate its biological effect and specify any disease association.
Pathogenic; Androgen resistance syndrome
GACCCAATTTTCCAGGTGCCATCTGTCACAGCTTTGCTTGGCTAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAA...
GACCCAATTTTCCAGGTGCCATCTGTCACAGCTTTGCTTGGCTAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAA...
Task1_train_30080
Located on Chromosome X, this mutation impacts AR (androgen receptor). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Androgen resistance syndrome
TCACAGCTTTGCTTGGCTAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAG...
TCACAGCTTTGCTTGGCTAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAG...
Task1_train_30081
A variant was discovered on Chromosome X, affecting AR (androgen receptor). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Androgen resistance syndrome
TAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATA...
TAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATA...
Task1_train_30082
Consider this mutation in AR (androgen receptor) on Chromosome X. Is this a benign change or a disease-causing variant?
Pathogenic; Kennedy disease
TAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATA...
TAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATA...
Task1_train_30083
This gene mutation involves AR (androgen receptor) on Chromosome X. Is it associated with any clinical condition, or is it benign?
Pathogenic; Androgen resistance syndrome
TAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATA...
TAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATA...
Task1_train_30084
This is a variant in AR (androgen receptor), located on Chromosome X. Is this mutation a likely cause of disease or not?
Pathogenic; Inborn genetic diseases
TAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATA...
TAGGAAAGGGAATTTCCTGACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATA...
Task1_train_30085
Here is a genetic alteration in AR (androgen receptor) on Chromosome X. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Androgen resistance syndrome
GACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGG...
GACCCTTTGCACTTCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGG...
Task1_train_30086
Mutation context: Chromosome X, Gene AR (androgen receptor). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Androgen resistance syndrome
TCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCT...
TCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCT...
Task1_train_30087
A change on Chromosome X affects gene AR (androgen receptor). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Kennedy disease
TCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCT...
TCCCGGGTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCT...
Task1_train_30088
The variant affects gene AR (androgen receptor), which is on Chromosome X. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Androgen resistance syndrome
GTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGG...
GTGAGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGG...
Task1_train_30089
This alteration in AR (androgen receptor) on Chromosome X may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Androgen resistance syndrome
AGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCA...
AGGCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCA...
Task1_train_30090
Consider a variant on Chromosome X in gene AR (androgen receptor). Determine its clinical classification and disease relevance.
Pathogenic; Androgen resistance syndrome
GCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACT...
GCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACT...
Task1_train_30091
This mutation occurs in AR (androgen receptor) on Chromosome X. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Kennedy disease
GCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACT...
GCGATGCCTCTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACT...
Task1_train_30092
This mutation is located in gene AR (androgen receptor) on Chromosome X. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Kennedy disease
CTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACTTTTAAAAAC...
CTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACTTTTAAAAAC...
Task1_train_30093
This genomic variant is located on Chromosome X, within the AR (androgen receptor) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Androgen resistance syndrome
CTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACTTTTAAAAAC...
CTCCCTGCTTTGGCTCACACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACTTTTAAAAAC...
Task1_train_30094
This variant impacts the gene AR (androgen receptor) on Chromosome X. Is the change likely to result in a pathogenic outcome?
Pathogenic; Androgen resistance syndrome
ACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACTTTTAAAAACCCCATTCCCATATGATGC...
ACTTGGTGCACTGCACCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACTTTTAAAAACCCCATTCCCATATGATGC...
Task1_train_30095
A variant has been detected on Chromosome X in AR (androgen receptor). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Androgen resistance syndrome
CCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACTTTTAAAAACCCCATTCCCATATGATGCTTGAATTCTTAACCA...
CCCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACTTTTAAAAACCCCATTCCCATATGATGCTTGAATTCTTAACCA...
Task1_train_30096
This mutation is located in gene AR (androgen receptor) on Chromosome X. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Androgen resistance syndrome
CCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACTTTTAAAAACCCCATTCCCATATGATGCTTGAATTCTTAACCAC...
CCACTGTCCTGTACCCACTGTCCAACAAGCCCCAGTGAGATGAACCCGGTACCTCAGTCGGAAATGCAGAAATCACTCATCTTCTGCGTCACTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCTTATGAATCATGCATGTTCAACTATGAGCAACTATGTGTATTCAATGGGAAATGGAATACCATAAAATTGTCATATGTTGAGCCCAAAATGATAGGATAGAATTTGATAGTCTGAGGATGGAAAGGACCTTCAAGGCCACTTTTAAAAACCCCATTCCCATATGATGCTTGAATTCTTAACCAC...
Task1_train_30097
An alteration has been detected in AR (androgen receptor) on Chromosome X. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Androgen resistance syndrome
ACCTGGAAGGCCTAGGATCTAAAAGAAAAGAACAGGGAAATGGGGCTATATGAGTGGACAGGGACCAACCAAGCAGAACAATGTGTCTGGATAATGTAGACTTCAGACCTGATCCTATGGCTGACAAAAGCTGGTGACCTTGGTAGTTCCTGAGCTGTAACCTTCATTAGTGGAGTAGAAAAAACACTGGAGAAGAGAATCAGAACACCTGGGTTCTAGTATTAGTTCAGCCACATATAAACCATATGACCTTGGGTAAGTCAGTTTATTTCTCTGGCCCTCATGTTCCTTGTTGGTAAAATAAGTGCCACATCACCTAA...
ACCTGGAAGGCCTAGGATCTAAAAGAAAAGAACAGGGAAATGGGGCTATATGAGTGGACAGGGACCAACCAAGCAGAACAATGTGTCTGGATAATGTAGACTTCAGACCTGATCCTATGGCTGACAAAAGCTGGTGACCTTGGTAGTTCCTGAGCTGTAACCTTCATTAGTGGAGTAGAAAAAACACTGGAGAAGAGAATCAGAACACCTGGGTTCTAGTATTAGTTCAGCCACATATAAACCATATGACCTTGGGTAAGTCAGTTTATTTCTCTGGCCCTCATGTTCCTTGTTGGTAAAATAAGTGCCACATCACCTAA...
Task1_train_30098
Chromosome X houses a mutation in gene AR (androgen receptor). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Kennedy disease
ACCTGGAAGGCCTAGGATCTAAAAGAAAAGAACAGGGAAATGGGGCTATATGAGTGGACAGGGACCAACCAAGCAGAACAATGTGTCTGGATAATGTAGACTTCAGACCTGATCCTATGGCTGACAAAAGCTGGTGACCTTGGTAGTTCCTGAGCTGTAACCTTCATTAGTGGAGTAGAAAAAACACTGGAGAAGAGAATCAGAACACCTGGGTTCTAGTATTAGTTCAGCCACATATAAACCATATGACCTTGGGTAAGTCAGTTTATTTCTCTGGCCCTCATGTTCCTTGTTGGTAAAATAAGTGCCACATCACCTAA...
ACCTGGAAGGCCTAGGATCTAAAAGAAAAGAACAGGGAAATGGGGCTATATGAGTGGACAGGGACCAACCAAGCAGAACAATGTGTCTGGATAATGTAGACTTCAGACCTGATCCTATGGCTGACAAAAGCTGGTGACCTTGGTAGTTCCTGAGCTGTAACCTTCATTAGTGGAGTAGAAAAAACACTGGAGAAGAGAATCAGAACACCTGGGTTCTAGTATTAGTTCAGCCACATATAAACCATATGACCTTGGGTAAGTCAGTTTATTTCTCTGGCCCTCATGTTCCTTGTTGGTAAAATAAGTGCCACATCACCTAA...
Task1_train_30099
This mutation occurs in AR (androgen receptor) on Chromosome X. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Kennedy disease
GGAAGGCCTAGGATCTAAAAGAAAAGAACAGGGAAATGGGGCTATATGAGTGGACAGGGACCAACCAAGCAGAACAATGTGTCTGGATAATGTAGACTTCAGACCTGATCCTATGGCTGACAAAAGCTGGTGACCTTGGTAGTTCCTGAGCTGTAACCTTCATTAGTGGAGTAGAAAAAACACTGGAGAAGAGAATCAGAACACCTGGGTTCTAGTATTAGTTCAGCCACATATAAACCATATGACCTTGGGTAAGTCAGTTTATTTCTCTGGCCCTCATGTTCCTTGTTGGTAAAATAAGTGCCACATCACCTAACCTC...
GGAAGGCCTAGGATCTAAAAGAAAAGAACAGGGAAATGGGGCTATATGAGTGGACAGGGACCAACCAAGCAGAACAATGTGTCTGGATAATGTAGACTTCAGACCTGATCCTATGGCTGACAAAAGCTGGTGACCTTGGTAGTTCCTGAGCTGTAACCTTCATTAGTGGAGTAGAAAAAACACTGGAGAAGAGAATCAGAACACCTGGGTTCTAGTATTAGTTCAGCCACATATAAACCATATGACCTTGGGTAAGTCAGTTTATTTCTCTGGCCCTCATGTTCCTTGTTGGTAAAATAAGTGCCACATCACCTAACCTC...