ID
stringlengths
13
17
question
stringlengths
88
1.13k
answer
stringlengths
6
156
reference_sequence
stringlengths
4.1k
4.1k
variant_sequence
stringlengths
4.1k
4.1k
Task1_train_26500
A genetic alteration is present in LDLR (low density lipoprotein receptor) on Chromosome 19. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Hypercholesterolemia, familial, 1
CCCGGACTTTTGTTGTTTTATATCTATATATCTATATATAACTTGTTTTATGTATATATATAACTTGTTTTATATATATACATAAACTGCAGTAAAAAACATGTAACATAAAATTTACCTTCTCAAACCTTATTAAGTGCACAGTTCTGTGCCATTAGCAAATTCACACTGTTGTACAACATCACAACCACCATCTCCAGAACTTTTTTTTTTTTTTTTATTCTTTTTGAGACAGAGTCTCACTCGTCGCACGGGCTGGAGTGCAGTGGTGCGATCTCGGTTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCCCCTCAGTAGCTGGGATTACAGGTGCCCGTCCTACCACGCCCAGCTAATTTTTGTATTTTCAGTAGAGACTGACTGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGAATACAGGCATGAGCCACTGCGCCCGGCCCCAGAACTCTTTTATCTTCCCAAACTGAAGCTCTGTCCCCATGAAACACTCACTCTCCATCCCCTCCCCAACTCCTGGCACCCACCATTCTACTTTCTGTCCCTATGAATGTGATGGCTCTAGGGACCTCCTCTGAGTGGAATCAGACAGCATTTTCCTTTTTTGACTGGCTTATTTCACTGAGCCAAGTGCGGTGGCACACGCCTGTAATCCCAAAACTTTGGGAGACCGAGGCGGGCGCATCACCTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTAGTAAAAATACAAAAAATTAGCCTGTCATGGTCGTGGGTGCCTGTAATCCCAGCTAAGTGGGAGGCTGAGGCAGGAGAATCGCTTGTACCCAGGAGGCGGAGGTCGCAGTGAGCCGAGATCGTGCCATTACACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCTCCTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTAATGAGCCAAGGTTGGCGGCGAAGGGATGGGTAGGGGCCCGAGAGTGACCAGTCTGCATCCCCTGGCCCTGCGCAGGGACCAACGAATGCTTGGACAACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGCCCCGACGGCTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGGTGATTCCCGGGTGGGACTGAGCCCTGGGCCCCCTCTGCGCTTCCTGACATGGCAACCAAACCCCTCATGCCTCAGTTTCCCCATCTGTTAAGTGTGCTTGAAAGCAGTTAGGAGGGTTTCATGAGATTCCACCTGCATGGAAAACTATCATTGGCTGGCCAGAGTTTCTTGCCTCTGGGGATTAGTAATTAAGAAATTTCAGGCCGGGTGCGTAATCCCTGTAATCCCAACACCTTGGGACGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCCAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCTTGGTGGTGCATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCA
CCCGGACTTTTGTTGTTTTATATCTATATATCTATATATAACTTGTTTTATGTATATATATAACTTGTTTTATATATATACATAAACTGCAGTAAAAAACATGTAACATAAAATTTACCTTCTCAAACCTTATTAAGTGCACAGTTCTGTGCCATTAGCAAATTCACACTGTTGTACAACATCACAACCACCATCTCCAGAACTTTTTTTTTTTTTTTTATTCTTTTTGAGACAGAGTCTCACTCGTCGCACGGGCTGGAGTGCAGTGGTGCGATCTCGGTTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCCCCTCAGTAGCTGGGATTACAGGTGCCCGTCCTACCACGCCCAGCTAATTTTTGTATTTTCAGTAGAGACTGACTGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGAATACAGGCATGAGCCACTGCGCCCGGCCCCAGAACTCTTTTATCTTCCCAAACTGAAGCTCTGTCCCCATGAAACACTCACTCTCCATCCCCTCCCCAACTCCTGGCACCCACCATTCTACTTTCTGTCCCTATGAATGTGATGGCTCTAGGGACCTCCTCTGAGTGGAATCAGACAGCATTTTCCTTTTTTGACTGGCTTATTTCACTGAGCCAAGTGCGGTGGCACACGCCTGTAATCCCAAAACTTTGGGAGACCGAGGCGGGCGCATCACCTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTAGTAAAAATACAAAAAATTAGCCTGTCATGGTCGTGGGTGCCTGTAATCCCAGCTAAGTGGGAGGCTGAGGCAGGAGAATCGCTTGTACCCAGGAGGCGGAGGTCGCAGTGAGCCGAGATCGTGCCATTACACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCTCCTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTAATGAGCCAAGGTTGGCGGCGAAGGGATGGGTAGGGGCCCGAGAGTGACCAGTCTGCATCCCCTGGCCCTGCGCAGGGACCAACGAATGCTTGGACAACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGCCCCGACGGCTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGGTGATTCCCGGGTGGGACTGAGCCCTGGGCCCCCTCTGCGCTTCCTGACATGGCAACCAAACCCCTCATGCCTCAGTTTCCCCATCTGTTAAGTGTGCTTGAAAGCAGTTAGGAGGGTTTCATGAGATTCCACCTGCATGGAAAACTATCATTGGCTGGCCAGAGTTTCTTGCCTCTGGGGATTAGTAATTAAGAAATTTCAGGCCGGGTGCGTAATCCCTGTAATCCCAACACCTTGGGACGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCCAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCTTGGTGGTGCATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATTCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCA
Task1_train_26501
The following genetic variant occurs in LDLR (low density lipoprotein receptor) on Chromosome 19. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Familial hypercholesterolemia
ATCTATATATCTATATATAACTTGTTTTATGTATATATATAACTTGTTTTATATATATACATAAACTGCAGTAAAAAACATGTAACATAAAATTTACCTTCTCAAACCTTATTAAGTGCACAGTTCTGTGCCATTAGCAAATTCACACTGTTGTACAACATCACAACCACCATCTCCAGAACTTTTTTTTTTTTTTTTATTCTTTTTGAGACAGAGTCTCACTCGTCGCACGGGCTGGAGTGCAGTGGTGCGATCTCGGTTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCCCCTCAGTAGCTGGGATTACAGGTGCCCGTCCTACCACGCCCAGCTAATTTTTGTATTTTCAGTAGAGACTGACTGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGAATACAGGCATGAGCCACTGCGCCCGGCCCCAGAACTCTTTTATCTTCCCAAACTGAAGCTCTGTCCCCATGAAACACTCACTCTCCATCCCCTCCCCAACTCCTGGCACCCACCATTCTACTTTCTGTCCCTATGAATGTGATGGCTCTAGGGACCTCCTCTGAGTGGAATCAGACAGCATTTTCCTTTTTTGACTGGCTTATTTCACTGAGCCAAGTGCGGTGGCACACGCCTGTAATCCCAAAACTTTGGGAGACCGAGGCGGGCGCATCACCTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTAGTAAAAATACAAAAAATTAGCCTGTCATGGTCGTGGGTGCCTGTAATCCCAGCTAAGTGGGAGGCTGAGGCAGGAGAATCGCTTGTACCCAGGAGGCGGAGGTCGCAGTGAGCCGAGATCGTGCCATTACACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCTCCTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTAATGAGCCAAGGTTGGCGGCGAAGGGATGGGTAGGGGCCCGAGAGTGACCAGTCTGCATCCCCTGGCCCTGCGCAGGGACCAACGAATGCTTGGACAACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGCCCCGACGGCTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGGTGATTCCCGGGTGGGACTGAGCCCTGGGCCCCCTCTGCGCTTCCTGACATGGCAACCAAACCCCTCATGCCTCAGTTTCCCCATCTGTTAAGTGTGCTTGAAAGCAGTTAGGAGGGTTTCATGAGATTCCACCTGCATGGAAAACTATCATTGGCTGGCCAGAGTTTCTTGCCTCTGGGGATTAGTAATTAAGAAATTTCAGGCCGGGTGCGTAATCCCTGTAATCCCAACACCTTGGGACGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCCAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCTTGGTGGTGCATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCC
ATCTATATATCTATATATAACTTGTTTTATGTATATATATAACTTGTTTTATATATATACATAAACTGCAGTAAAAAACATGTAACATAAAATTTACCTTCTCAAACCTTATTAAGTGCACAGTTCTGTGCCATTAGCAAATTCACACTGTTGTACAACATCACAACCACCATCTCCAGAACTTTTTTTTTTTTTTTTATTCTTTTTGAGACAGAGTCTCACTCGTCGCACGGGCTGGAGTGCAGTGGTGCGATCTCGGTTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCCCCTCAGTAGCTGGGATTACAGGTGCCCGTCCTACCACGCCCAGCTAATTTTTGTATTTTCAGTAGAGACTGACTGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGAATACAGGCATGAGCCACTGCGCCCGGCCCCAGAACTCTTTTATCTTCCCAAACTGAAGCTCTGTCCCCATGAAACACTCACTCTCCATCCCCTCCCCAACTCCTGGCACCCACCATTCTACTTTCTGTCCCTATGAATGTGATGGCTCTAGGGACCTCCTCTGAGTGGAATCAGACAGCATTTTCCTTTTTTGACTGGCTTATTTCACTGAGCCAAGTGCGGTGGCACACGCCTGTAATCCCAAAACTTTGGGAGACCGAGGCGGGCGCATCACCTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTAGTAAAAATACAAAAAATTAGCCTGTCATGGTCGTGGGTGCCTGTAATCCCAGCTAAGTGGGAGGCTGAGGCAGGAGAATCGCTTGTACCCAGGAGGCGGAGGTCGCAGTGAGCCGAGATCGTGCCATTACACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCTCCTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTAATGAGCCAAGGTTGGCGGCGAAGGGATGGGTAGGGGCCCGAGAGTGACCAGTCTGCATCCCCTGGCCCTGCGCAGGGACCAACGAATGCTTGGACAACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGCCCCGACGGCTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGGTGATTCCCGGGTGGGACTGAGCCCTGGGCCCCCTCTGCGCTTCCTGACATGGCAACCAAACCCCTCATGCCTCAGTTTCCCCATCTGTTAAGTGTGCTTGAAAGCAGTTAGGAGGGTTTCATGAGATTCCACCTGCATGGAAAACTATCATTGGCTGGCCAGAGTTTCTTGCCTCTGGGGATTAGTAATTAAGAAATTTCAGGCCGGGTGCGTAATCCCTGTAATCCCAACACCTTGGGACGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCCAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCTTGGTGGTGCATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCAGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCC
Task1_train_26502
Consider a variant on Chromosome 19 in gene LDLR (low density lipoprotein receptor). Determine its clinical classification and disease relevance.
Pathogenic; Familial hypercholesterolemia
TATGTATATATATAACTTGTTTTATATATATACATAAACTGCAGTAAAAAACATGTAACATAAAATTTACCTTCTCAAACCTTATTAAGTGCACAGTTCTGTGCCATTAGCAAATTCACACTGTTGTACAACATCACAACCACCATCTCCAGAACTTTTTTTTTTTTTTTTATTCTTTTTGAGACAGAGTCTCACTCGTCGCACGGGCTGGAGTGCAGTGGTGCGATCTCGGTTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCCCCTCAGTAGCTGGGATTACAGGTGCCCGTCCTACCACGCCCAGCTAATTTTTGTATTTTCAGTAGAGACTGACTGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGAATACAGGCATGAGCCACTGCGCCCGGCCCCAGAACTCTTTTATCTTCCCAAACTGAAGCTCTGTCCCCATGAAACACTCACTCTCCATCCCCTCCCCAACTCCTGGCACCCACCATTCTACTTTCTGTCCCTATGAATGTGATGGCTCTAGGGACCTCCTCTGAGTGGAATCAGACAGCATTTTCCTTTTTTGACTGGCTTATTTCACTGAGCCAAGTGCGGTGGCACACGCCTGTAATCCCAAAACTTTGGGAGACCGAGGCGGGCGCATCACCTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTAGTAAAAATACAAAAAATTAGCCTGTCATGGTCGTGGGTGCCTGTAATCCCAGCTAAGTGGGAGGCTGAGGCAGGAGAATCGCTTGTACCCAGGAGGCGGAGGTCGCAGTGAGCCGAGATCGTGCCATTACACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCTCCTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTAATGAGCCAAGGTTGGCGGCGAAGGGATGGGTAGGGGCCCGAGAGTGACCAGTCTGCATCCCCTGGCCCTGCGCAGGGACCAACGAATGCTTGGACAACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGCCCCGACGGCTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGGTGATTCCCGGGTGGGACTGAGCCCTGGGCCCCCTCTGCGCTTCCTGACATGGCAACCAAACCCCTCATGCCTCAGTTTCCCCATCTGTTAAGTGTGCTTGAAAGCAGTTAGGAGGGTTTCATGAGATTCCACCTGCATGGAAAACTATCATTGGCTGGCCAGAGTTTCTTGCCTCTGGGGATTAGTAATTAAGAAATTTCAGGCCGGGTGCGTAATCCCTGTAATCCCAACACCTTGGGACGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCCAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCTTGGTGGTGCATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCC
TATGTATATATATAACTTGTTTTATATATATACATAAACTGCAGTAAAAAACATGTAACATAAAATTTACCTTCTCAAACCTTATTAAGTGCACAGTTCTGTGCCATTAGCAAATTCACACTGTTGTACAACATCACAACCACCATCTCCAGAACTTTTTTTTTTTTTTTTATTCTTTTTGAGACAGAGTCTCACTCGTCGCACGGGCTGGAGTGCAGTGGTGCGATCTCGGTTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCCCCTCAGTAGCTGGGATTACAGGTGCCCGTCCTACCACGCCCAGCTAATTTTTGTATTTTCAGTAGAGACTGACTGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGAATACAGGCATGAGCCACTGCGCCCGGCCCCAGAACTCTTTTATCTTCCCAAACTGAAGCTCTGTCCCCATGAAACACTCACTCTCCATCCCCTCCCCAACTCCTGGCACCCACCATTCTACTTTCTGTCCCTATGAATGTGATGGCTCTAGGGACCTCCTCTGAGTGGAATCAGACAGCATTTTCCTTTTTTGACTGGCTTATTTCACTGAGCCAAGTGCGGTGGCACACGCCTGTAATCCCAAAACTTTGGGAGACCGAGGCGGGCGCATCACCTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTAGTAAAAATACAAAAAATTAGCCTGTCATGGTCGTGGGTGCCTGTAATCCCAGCTAAGTGGGAGGCTGAGGCAGGAGAATCGCTTGTACCCAGGAGGCGGAGGTCGCAGTGAGCCGAGATCGTGCCATTACACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCTCCTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTAATGAGCCAAGGTTGGCGGCGAAGGGATGGGTAGGGGCCCGAGAGTGACCAGTCTGCATCCCCTGGCCCTGCGCAGGGACCAACGAATGCTTGGACAACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGCCCCGACGGCTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGGTGATTCCCGGGTGGGACTGAGCCCTGGGCCCCCTCTGCGCTTCCTGACATGGCAACCAAACCCCTCATGCCTCAGTTTCCCCATCTGTTAAGTGTGCTTGAAAGCAGTTAGGAGGGTTTCATGAGATTCCACCTGCATGGAAAACTATCATTGGCTGGCCAGAGTTTCTTGCCTCTGGGGATTAGTAATTAAGAAATTTCAGGCCGGGTGCGTAATCCCTGTAATCCCAACACCTTGGGACGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCCAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCTTGGTGGTGCATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGCGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCC
Task1_train_26503
Given a variant located on Chromosome 19 and affecting LDLR (low density lipoprotein receptor), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Cardiovascular phenotype
TATGTATATATATAACTTGTTTTATATATATACATAAACTGCAGTAAAAAACATGTAACATAAAATTTACCTTCTCAAACCTTATTAAGTGCACAGTTCTGTGCCATTAGCAAATTCACACTGTTGTACAACATCACAACCACCATCTCCAGAACTTTTTTTTTTTTTTTTATTCTTTTTGAGACAGAGTCTCACTCGTCGCACGGGCTGGAGTGCAGTGGTGCGATCTCGGTTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCCCCTCAGTAGCTGGGATTACAGGTGCCCGTCCTACCACGCCCAGCTAATTTTTGTATTTTCAGTAGAGACTGACTGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGAATACAGGCATGAGCCACTGCGCCCGGCCCCAGAACTCTTTTATCTTCCCAAACTGAAGCTCTGTCCCCATGAAACACTCACTCTCCATCCCCTCCCCAACTCCTGGCACCCACCATTCTACTTTCTGTCCCTATGAATGTGATGGCTCTAGGGACCTCCTCTGAGTGGAATCAGACAGCATTTTCCTTTTTTGACTGGCTTATTTCACTGAGCCAAGTGCGGTGGCACACGCCTGTAATCCCAAAACTTTGGGAGACCGAGGCGGGCGCATCACCTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTAGTAAAAATACAAAAAATTAGCCTGTCATGGTCGTGGGTGCCTGTAATCCCAGCTAAGTGGGAGGCTGAGGCAGGAGAATCGCTTGTACCCAGGAGGCGGAGGTCGCAGTGAGCCGAGATCGTGCCATTACACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCTCCTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTAATGAGCCAAGGTTGGCGGCGAAGGGATGGGTAGGGGCCCGAGAGTGACCAGTCTGCATCCCCTGGCCCTGCGCAGGGACCAACGAATGCTTGGACAACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGCCCCGACGGCTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGGTGATTCCCGGGTGGGACTGAGCCCTGGGCCCCCTCTGCGCTTCCTGACATGGCAACCAAACCCCTCATGCCTCAGTTTCCCCATCTGTTAAGTGTGCTTGAAAGCAGTTAGGAGGGTTTCATGAGATTCCACCTGCATGGAAAACTATCATTGGCTGGCCAGAGTTTCTTGCCTCTGGGGATTAGTAATTAAGAAATTTCAGGCCGGGTGCGTAATCCCTGTAATCCCAACACCTTGGGACGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCCAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCTTGGTGGTGCATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCC
TATGTATATATATAACTTGTTTTATATATATACATAAACTGCAGTAAAAAACATGTAACATAAAATTTACCTTCTCAAACCTTATTAAGTGCACAGTTCTGTGCCATTAGCAAATTCACACTGTTGTACAACATCACAACCACCATCTCCAGAACTTTTTTTTTTTTTTTTATTCTTTTTGAGACAGAGTCTCACTCGTCGCACGGGCTGGAGTGCAGTGGTGCGATCTCGGTTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCCCCTCAGTAGCTGGGATTACAGGTGCCCGTCCTACCACGCCCAGCTAATTTTTGTATTTTCAGTAGAGACTGACTGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGAATACAGGCATGAGCCACTGCGCCCGGCCCCAGAACTCTTTTATCTTCCCAAACTGAAGCTCTGTCCCCATGAAACACTCACTCTCCATCCCCTCCCCAACTCCTGGCACCCACCATTCTACTTTCTGTCCCTATGAATGTGATGGCTCTAGGGACCTCCTCTGAGTGGAATCAGACAGCATTTTCCTTTTTTGACTGGCTTATTTCACTGAGCCAAGTGCGGTGGCACACGCCTGTAATCCCAAAACTTTGGGAGACCGAGGCGGGCGCATCACCTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTAGTAAAAATACAAAAAATTAGCCTGTCATGGTCGTGGGTGCCTGTAATCCCAGCTAAGTGGGAGGCTGAGGCAGGAGAATCGCTTGTACCCAGGAGGCGGAGGTCGCAGTGAGCCGAGATCGTGCCATTACACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCTCCTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTAATGAGCCAAGGTTGGCGGCGAAGGGATGGGTAGGGGCCCGAGAGTGACCAGTCTGCATCCCCTGGCCCTGCGCAGGGACCAACGAATGCTTGGACAACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGCCCCGACGGCTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGGTGATTCCCGGGTGGGACTGAGCCCTGGGCCCCCTCTGCGCTTCCTGACATGGCAACCAAACCCCTCATGCCTCAGTTTCCCCATCTGTTAAGTGTGCTTGAAAGCAGTTAGGAGGGTTTCATGAGATTCCACCTGCATGGAAAACTATCATTGGCTGGCCAGAGTTTCTTGCCTCTGGGGATTAGTAATTAAGAAATTTCAGGCCGGGTGCGTAATCCCTGTAATCCCAACACCTTGGGACGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCCAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCTTGGTGGTGCATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGCGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCC
Task1_train_26504
A mutation in LDLR (low density lipoprotein receptor), located on Chromosome 19, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Hypercholesterolemia, familial, 1
AACATGTAACATAAAATTTACCTTCTCAAACCTTATTAAGTGCACAGTTCTGTGCCATTAGCAAATTCACACTGTTGTACAACATCACAACCACCATCTCCAGAACTTTTTTTTTTTTTTTTATTCTTTTTGAGACAGAGTCTCACTCGTCGCACGGGCTGGAGTGCAGTGGTGCGATCTCGGTTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCCCCTCAGTAGCTGGGATTACAGGTGCCCGTCCTACCACGCCCAGCTAATTTTTGTATTTTCAGTAGAGACTGACTGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGAATACAGGCATGAGCCACTGCGCCCGGCCCCAGAACTCTTTTATCTTCCCAAACTGAAGCTCTGTCCCCATGAAACACTCACTCTCCATCCCCTCCCCAACTCCTGGCACCCACCATTCTACTTTCTGTCCCTATGAATGTGATGGCTCTAGGGACCTCCTCTGAGTGGAATCAGACAGCATTTTCCTTTTTTGACTGGCTTATTTCACTGAGCCAAGTGCGGTGGCACACGCCTGTAATCCCAAAACTTTGGGAGACCGAGGCGGGCGCATCACCTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTAGTAAAAATACAAAAAATTAGCCTGTCATGGTCGTGGGTGCCTGTAATCCCAGCTAAGTGGGAGGCTGAGGCAGGAGAATCGCTTGTACCCAGGAGGCGGAGGTCGCAGTGAGCCGAGATCGTGCCATTACACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCTCCTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTAATGAGCCAAGGTTGGCGGCGAAGGGATGGGTAGGGGCCCGAGAGTGACCAGTCTGCATCCCCTGGCCCTGCGCAGGGACCAACGAATGCTTGGACAACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGCCCCGACGGCTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGGTGATTCCCGGGTGGGACTGAGCCCTGGGCCCCCTCTGCGCTTCCTGACATGGCAACCAAACCCCTCATGCCTCAGTTTCCCCATCTGTTAAGTGTGCTTGAAAGCAGTTAGGAGGGTTTCATGAGATTCCACCTGCATGGAAAACTATCATTGGCTGGCCAGAGTTTCTTGCCTCTGGGGATTAGTAATTAAGAAATTTCAGGCCGGGTGCGTAATCCCTGTAATCCCAACACCTTGGGACGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCCAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCTTGGTGGTGCATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGC
AACATGTAACATAAAATTTACCTTCTCAAACCTTATTAAGTGCACAGTTCTGTGCCATTAGCAAATTCACACTGTTGTACAACATCACAACCACCATCTCCAGAACTTTTTTTTTTTTTTTTATTCTTTTTGAGACAGAGTCTCACTCGTCGCACGGGCTGGAGTGCAGTGGTGCGATCTCGGTTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCCCCTCAGTAGCTGGGATTACAGGTGCCCGTCCTACCACGCCCAGCTAATTTTTGTATTTTCAGTAGAGACTGACTGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGAATACAGGCATGAGCCACTGCGCCCGGCCCCAGAACTCTTTTATCTTCCCAAACTGAAGCTCTGTCCCCATGAAACACTCACTCTCCATCCCCTCCCCAACTCCTGGCACCCACCATTCTACTTTCTGTCCCTATGAATGTGATGGCTCTAGGGACCTCCTCTGAGTGGAATCAGACAGCATTTTCCTTTTTTGACTGGCTTATTTCACTGAGCCAAGTGCGGTGGCACACGCCTGTAATCCCAAAACTTTGGGAGACCGAGGCGGGCGCATCACCTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTAGTAAAAATACAAAAAATTAGCCTGTCATGGTCGTGGGTGCCTGTAATCCCAGCTAAGTGGGAGGCTGAGGCAGGAGAATCGCTTGTACCCAGGAGGCGGAGGTCGCAGTGAGCCGAGATCGTGCCATTACACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCTCCTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTAATGAGCCAAGGTTGGCGGCGAAGGGATGGGTAGGGGCCCGAGAGTGACCAGTCTGCATCCCCTGGCCCTGCGCAGGGACCAACGAATGCTTGGACAACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGCCCCGACGGCTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGGTGATTCCCGGGTGGGACTGAGCCCTGGGCCCCCTCTGCGCTTCCTGACATGGCAACCAAACCCCTCATGCCTCAGTTTCCCCATCTGTTAAGTGTGCTTGAAAGCAGTTAGGAGGGTTTCATGAGATTCCACCTGCATGGAAAACTATCATTGGCTGGCCAGAGTTTCTTGCCTCTGGGGATTAGTAATTAAGAAATTTCAGGCCGGGTGCGTAATCCCTGTAATCCCAACACCTTGGGACGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCCAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCTTGGTGGTGCATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCACGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGC
Task1_train_26505
A sequence alteration has been identified in LDLR (low density lipoprotein receptor) on Chromosome 19. Is it disease-inducing or harmless?
Pathogenic; Familial hypercholesterolemia
GAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAG
GAAACTCCATCCAAAAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCTCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAG
Task1_train_26506
Here’s a variant in LDLR (low density lipoprotein receptor) located on Chromosome 19. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Familial hypercholesterolemia
AAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTG
AAAAAAAAGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTAACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTG
Task1_train_26507
This is a variant in LDLR (low density lipoprotein receptor), located on Chromosome 19. Is this mutation a likely cause of disease or not?
Pathogenic; Hypercholesterolemia, familial, 1
AGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAAT
AGAAAAGAAAAGAAAAAAAAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACTGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAAT
Task1_train_26508
This sequence variant lies in LDLR (low density lipoprotein receptor) on Chromosome 19. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Hypercholesterolemia, familial, 1
AAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCT
AAGAAAAGAAATTTCAGCTGACACAGCTTCACACTCTTGGTTGGGTTCCCGTGGTGAATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGCTGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCT
Task1_train_26509
This variant lies on Chromosome 19 and affects the gene LDLR (low density lipoprotein receptor). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Hypercholesterolemia, familial, 1
ATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTAC
ATGATGAGGTCAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCACTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTAC
Task1_train_26510
Given a variant located on Chromosome 19 and affecting LDLR (low density lipoprotein receptor), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Hypercholesterolemia, familial, 1
CAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACAC
CAGGTGATGACTGGGGATGACACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACAGGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACAC
Task1_train_26511
A variant affecting Chromosome 19, within the gene LDLR (low density lipoprotein receptor), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Hypercholesterolemia, familial, 1
ACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTAT
ACCTGGCTGTTTCCTTGATTACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAACCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTAT
Task1_train_26512
Given this context: Chromosome 19, gene LDLR (low density lipoprotein receptor) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; Hypercholesterolemia, familial, 1
ACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGA
ACATCTCCCGAGAGGCTGGGCTGTCTCCTGGCTGCCTTCGAAGGTGTGGGTTTTGGCCTGGGCCCCATCGCTCCGTCTCTAGCCATTGGGGAAGAGCCTCCCCACCAAGCCTCTTTCTCTCTCTTCCAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCAAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGA
Task1_train_26513
Here is a genetic alteration in LDLR (low density lipoprotein receptor) on Chromosome 19. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Hypercholesterolemia, familial, 1
TGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTG
TGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCTCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTG
Task1_train_26514
A variant was discovered on Chromosome 19, affecting LDLR (low density lipoprotein receptor). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Hypercholesterolemia, familial, 1
GAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTG
GAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACAGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTG
Task1_train_26515
A variant was discovered in gene LDLR (low density lipoprotein receptor), Chromosome 19. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Hypercholesterolemia, familial, 1
CTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGT
CTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCAGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGT
Task1_train_26516
This alteration occurs within gene LDLR (low density lipoprotein receptor) located on Chromosome 19. Is it associated with a disease or is it a benign variant?
Pathogenic; Familial hypercholesterolemia
GAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGT
GAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGTTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGT
Task1_train_26517
A variant affecting Chromosome 19, within the gene LDLR (low density lipoprotein receptor), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Hypercholesterolemia, familial, 1
TACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATA
TACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTTGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATA
Task1_train_26518
The gene LDLR (low density lipoprotein receptor) is located on Chromosome 19, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Hypercholesterolemia, familial, 1
ACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAG
ACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGCATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAG
Task1_train_26519
Here is a mutation in LDLR (low density lipoprotein receptor) on Chromosome 19. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Hypercholesterolemia, familial, 1
GGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTC
GGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGTGAGCACGGGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTTGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTC
Task1_train_26520
This mutation occurs in LDLR (low density lipoprotein receptor) on Chromosome 19. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Hypercholesterolemia, familial, 1
GGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGG
GGAAGGCGGCGGGTGGGGGCGGCCTCACCCCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAACAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGG
Task1_train_26521
A genetic alteration is present in LDLR (low density lipoprotein receptor) on Chromosome 19. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Hypercholesterolemia, familial, 1
CCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAA
CCTTGCAGGCAGCAGTGGTGGGGGAGTTTCATCCTCTGAACTTTGCACAGACTCATATCCCCTGACCGGGAGGCTGTTTGCTCCTGAGGGCTCTGGCAGGGGAGTCTGCCGCCCTGTTAGGACTTGGGCTTGCCAGGGGGATGCCTGCATATGTCCTAGTTTTTGGGAATATCCAGTTAACGGAACCCTCAGCCCTACTGGTGGAACAGGAACCGGCTTTCCTTTCAGGGACAACCTGGGGAGTGACTTCAAGGGGTTAAAGAAAAAAAATTAGCTGGGCATGGTGCCACACACCTGTGGTCCCAGCTACTCAGAAGGCTGAGGCGGGAGGATTGCTTGAGGGCAGGAGGATTGGTTGATCCTCCCACCTCAGCCTCCGGAGTAGCTGGGACCTCAGGTGCATGCCACTATGCCTGGCTAATTTTCTTTTTTCTTTTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGAGCCCGCCACTGCACCAGGCCAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTCGGATTACAGGCGTGAGCCACTGCGCCCAGCCGCTAATTTTCATATTTTTAGTAAAAACAGGGTTTCACCATGTTGGCCAGGCTAGTCTTGAACTCCTGAACCCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACACCACACCTGGCTATTATTATTTTTTAGAGACAGGGTGCTGCTCTATCTTCCAGCCTGTAGTGCAGTGCAGCCTCCATCATAGCTCGCTGCAGCCTTGACCTCCTGGGTTCACGTGATCGTCCCGCCTAAGCCTCTGGAGGAGCTGGGAGTACTGGCATGTGCCACCATGCCTGGTTAATTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCATTCTGTCACCCAGGCTGGAGTGCGGTGGTGCGATCTTGGCTTACTGAAACCTCCACCTCCCAGGTTCCAGCAATTCTCCTGCCTCACCCTTCTGAGTAGCTGGGATTACAGGTTCCGGCTACCAAACCTGGCTAGTTTTTGTATGTTTAGTAGAGACAGGGTTTCACCATGTTGGTGAGGCTGGTCTCGATTCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACCGTGCCTGGCTTTTTTTTTTTTTTTTTTTTTTGTGGCAATAAGGTCTCATTGTCTTGCCCAGGCTAGCCTTATGCTCCTAGCCTCAAGTGATCCTCCTCCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGGGCGCCACTGTGCCTGTTCCCGTTGGGAGGTCTTTTCCACCCTCTTTTTCTGGGTGCCTCCTCTGGCTCAGCCGCACCCTGCAGGATGACACAAGGGGATGGGGAGGCACTCTTGGTTCCATCGACGGGTCCCCTCTGACCCCCTGACCTCGCTCCCCGGACCCCCAGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGGTGAGCGTCGCCCCTGCCTGCAGCCTTGGCCCGCAGGTGAGATGAGGGCTCCTGGCGCTGATGCCCTTCTCTCCTCCTGCCTCAGCACCCAGCTTGACAGAGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTTCAAGCCAAGGGCCATCGTGGTGGATCCTGTTCATGGGTGCGTATCCACGACGCTGAGGGCTGCAGAGGGAATGGAGGGAGCAGGAAGGAGCTTCAGGAACTGGTTAGTGGGCTGGGCATGGTGGCTCAAAGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCATCAAGACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGATGGAGGTTGCAGTGAGCCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAA
Task1_train_26522
Here’s a variant in LDLR (low density lipoprotein receptor) located on Chromosome 19. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Hypercholesterolemia, familial, 1
CCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATG
CCAAGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGAACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATG
Task1_train_26523
Consider a variant on Chromosome 19 in gene LDLR (low density lipoprotein receptor). Determine its clinical classification and disease relevance.
Pathogenic; Cardiovascular phenotype
AGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTG
AGACAGCCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACAGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTG
Task1_train_26524
This sequence variant lies in LDLR (low density lipoprotein receptor) on Chromosome 19. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Hypercholesterolemia, familial, 1
CCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGG
CCCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTAACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGG
Task1_train_26525
This alteration occurs within gene LDLR (low density lipoprotein receptor) located on Chromosome 19. Is it associated with a disease or is it a benign variant?
Pathogenic; Hypercholesterolemia, familial, 1
GCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCC
GCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAACTAAACAAAAAACTGGTTAGTGGCTAGACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCACCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCC
Task1_train_26526
A variant was discovered in gene LDLR (low density lipoprotein receptor), Chromosome 19. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Hypercholesterolemia, familial, 1
ACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTG
ACAACAGGATGGTATCTTCCAAGCCCATGGCTGACTCAGCAGCTCCTGGGTCAAGACACTGTGACCTGTGTCCCCTGGCAGGAAGCATCGCCCCTGCCACCTGCCCGGTGTACTCTGTACCTGTCAGGTGACATCTGCTACCTAAGCACGTGAGAGGTGGCATTTCACAGTTTCAGTGTGGTGCTGACAACCCGGGACGCACACTGTCCTTGCAGCTACAATCAGGAGGTGAATGTTGGGTTTCCAGCAGAGAACACTGGAGAAGGCACACTTGGTGTCTGGAAGGGAAAAGCAGGGAAGAGAGCATCATCAGATGCCTGCGGGTGAAGGTGGGCCCGCTATGGCCAGCGTCCCTTTTTATTTTTATTTATTTATTTATTTGAGATGGAATCTCGCTCTGTCGCCCAGACTGTAGTGCAGTGGTGCGATCACGGCTCACTGCAAGCTCCGCCTCACAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCGGTTAATTTTTTGCATTTTTATTAGAGACGGGGTTTCACCGCGTTAGCCAGGATGGTCTAAATCTCCTGACCCTGTGATCCACCCGCCTCGGCCTCCCTAAGTGCTTGGATTACAAGCGTGAGCCACCACGCCCGGCCCCCTTTTTATTTTTTATTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCACTGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTG
Task1_train_26527
Given this variant in gene LDLR (low density lipoprotein receptor) on Chromosome 19, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Familial hypercholesterolemia
GAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCT
GAGACGGAGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACAGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCT
Task1_train_26528
A variant has been detected on Chromosome 19 in LDLR (low density lipoprotein receptor). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Hypercholesterolemia, familial, 1
AGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGG
AGTCTCGCTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGTCTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGG
Task1_train_26529
This gene mutation involves LDLR (low density lipoprotein receptor) on Chromosome 19. Is it associated with any clinical condition, or is it benign?
Pathogenic; LDLR-related disorder
CTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGA
CTCTGTCGCCCAGGCTAGATTGCAGTGGCGTGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAATCTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGA
Task1_train_26530
This variant affects the gene LDLR (low density lipoprotein receptor) found on Chromosome 19. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Hypercholesterolemia, familial, 1
ATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGA
ATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGAGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGA
Task1_train_26531
This mutation occurs in LDLR (low density lipoprotein receptor) on Chromosome 19. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Hypercholesterolemia, familial, 1
TCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAG
TCACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACTGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAG
Task1_train_26532
This variant lies on Chromosome 19 and affects the gene LDLR (low density lipoprotein receptor). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Hypercholesterolemia, familial, 1
CACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGT
CACTGCAGCCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCAGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGT
Task1_train_26533
A variant found in Chromosome 19 affects LDLR (low density lipoprotein receptor). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Hypercholesterolemia, familial, 1
TCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGT
TCCTGCCTCAACCTCCCAACTAATTAGGATTACAAGCATGTACCACCATGCCTGACTAATTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACCCTTAGCCTCAAGTAATCTGCCTGCCTCAGCCTCCCAAACAGCGGGGATTACAGGCATGAGCCACTGTGCCCAACCCAACCCTGGATCTCTTTTAAACAAGACAATGCTCGCTGTTGCCACAGAACAATGGGTGGGGTACATGTGGCCCAGTGTGTTTGGCCACATAACTGCCAGGCCAGAGGGAAAGAGACTCTCAGACTGTCTCCACTCAGATACAAATGTGTGTGTTGTGTGCGTGTGTTCTGGTCTCATATTTGTTTGTTTTGAGACAGGGTGTCGCTCTGTCACTGAGTCTGGAGTGCAGTGGCGCAATCAGAGTTCACTGCAGCCTCAAACTCTTGGGCTCAGTTGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGAACTACAGGTGAACACCACTGTGCCCAGCTAATTTATTTTATTTTTAGTAGAGATGAGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTAGCCTCAAGCAATCCTCCTGCCTTGGTCTCCCAAAGTGCTGGGATTACACGTGCGAGCCATTGCGCATGGCTTGTGTTCTTGTGTTTCTTCCTTTTTCTTTCGAGATGGCGTCTCAGTCTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGTAGCCTCAACTTCCTGGGCTCAAGCAATCCTCTTGATTTCAGCCTCCCGGGCCTGGCCAGCATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATGTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACACCAGAGGCTGAGGCAGGAGAATCGCTTGAGCCTGGAAGGTGGAGGTTGCAGCAAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGACAGACTCTGTCTCAAAAAAAAAAAAAAAAAACCCAAACAAGCCACATTTGGAGTTTGGGGTTCCCAGCAGGACTATTTCCCAAGCCTGAGCCTGGCTGTTTCTTCCAGAATTCGTTGCACGCATTGGCTGGGATCCTCCCCCGCCCTCCAGCCTCACAGCTATTCTCTGTCCTCCCACCAGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGGTATGTTCGCAGGACAGCCGTCCCAGCCAGGGCCGGGCACAGGCTGGAGGACAGACGGGGGTTGCCAGGTGGCTCTGGGACAAGCCCAAGCTGCTCCCTGAAGGTTTCCCTCTTTCTTTTCTTTGTTTTTTCTTTTTTTGAGATGAGGTCTTGGTCTGTCACCCAGGCTGGAGTGCACTGGCGCAATCGTAGCTCACTGCAGCCTCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCACCCTCCTGAGTAGCTGAGATTACAGACACGTGCCACCACGGCAGACTAATTTTATTTTATTTTTGGGAAGAGACAAAGTCTTGTTATGTTGGCCTGGCTGGTCTCAAACTCAGGGTGCAAGCGATCCTCCCGCCTCAGCCTTCCAAACTGCTGGGATTACAGGCGTGGGCCACCGTACCCAGCCTCCTTGAAGTTTTTCTGACCTGCAACTCCCCTACCTGCCCATTGGAGAGGGCGTCACAGGGGAGGGGTTCAGGCTCACATGTGGTTGGAGCTGCCTCTCCAGGTGCTTTTCTGCTAGGTCCCTGGCAGGGGGTCTTCCTGCCCGGAGCAGCGTGGCCAGGCCCTCAGGACCCTCTGGGACTGGCATCAGCACGTGACCTCTCCTTATCCACTTGTGTGTCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAAGACCATCTTGGAGGATGAAAAGAGGCTGGCCGACCCCTTCTCCTTGGCCGTCTTTGAGGTGTGGCTTACGTACGAGATGCAAGCACTTAGGTGGCGGATAGACACAGACTATAGATCACTCAAGCCAAGATGAACGCAGAAAACTGGTTGTGACTAGGAGGAGGTCTTAGACCTGAGTTATTTCTATTTTCTTCTTTCTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCGTTTCCCAGGCTGGAGGGCAATGGCATGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGGCTCCCCAGTAGCTGGGATTACAGGCATGCACCACCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACTTGAGCCACCGCGCCCAGCTATTTCTGTTTTCTTTCTTTCTTCTTCTTCTTTTTTTTTTTCTAAGAGACAGGATCTCACTCTGTCCCCAGGCAGGAGTGCAGTGCTGTGATCATAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGTGATCTTCCCACCTCAGCCTCCCAAGTAGCTGGAACTACAGGTGCACACCACCATGCCCAGCTCATTTTTGTATTTTTTTTTTTTTTGAGACAGTCTCGTTCTGTCACCCCGGCTGGAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGTTGAGATTACAGGCATGTGTGCCATCATACCTGGCTGATTTTTGTATTTTTTTTTAGAGATGGGGTCTCAGTATGTTGACCAGGCTTGTCTTAAACTCCCGGCCTCAAGTGATCCTCCCACTTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGGCCGGTTTGTTTTCTTTTTTTTTTCGTTTTTTGGAGACGGAATTTCACCTTTGTTGCCCAGGATGGAGTGCAATGGCACGATATCGCCTCACCACAACCTCTGCCTCCTGGGTTCAAACCATTTTCCTGCCTCAGCCTTCTTAGTAGCTGGGATTACAAGCATGTGCCACCACGCCCGGCTGATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGT
Task1_train_26534
This mutation is located in gene LDLR (low density lipoprotein receptor) on Chromosome 19. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Hypercholesterolemia, familial, 1
GGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCT
GGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTCATTCGCCCACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGTGGTTTGTATTCTTTTTACTGAGAGTCGTGAAAGGCAGTGATCCTCTGTCACATGTGATCTTGGCTCTCAGGGGACATTTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCAACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCT
Task1_train_26535
This variant lies on Chromosome 19 and affects the gene LDLR (low density lipoprotein receptor). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Hypercholesterolemia, familial, 1
TTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTGCAGGCGCCTGCCACTACGCCCGGCTACTTTTTTGTATATTTAGTAGAGATGGAGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCAGGCTTTTTTTTTTTTTTTTTTTTTT
TTGGCAATTTCTAGAGATTTTTTGGTTGTCACAAGTCAATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGCAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTGCAGGCGCCTGCCACTACGCCCGGCTACTTTTTTGTATATTTAGTAGAGATGGAGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCAGGCTTTTTTTTTTTTTTTTTTTTTT
Task1_train_26536
This mutation occurs in LDLR (low density lipoprotein receptor) on Chromosome 19. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Hypercholesterolemia, familial, 1
ATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTGCAGGCGCCTGCCACTACGCCCGGCTACTTTTTTGTATATTTAGTAGAGATGGAGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCAGGCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCA
ATGGGGAAGACTGTTGGCATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCTGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTGCAGGCGCCTGCCACTACGCCCGGCTACTTTTTTGTATATTTAGTAGAGATGGAGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCAGGCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCA
Task1_train_26537
Given this variant in gene LDLR (low density lipoprotein receptor) on Chromosome 19, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Hypercholesterolemia, familial, 1
CATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTGCAGGCGCCTGCCACTACGCCCGGCTACTTTTTTGTATATTTAGTAGAGATGGAGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCAGGCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCATGATCTCAGCT
CATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGGCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTGCAGGCGCCTGCCACTACGCCCGGCTACTTTTTTGTATATTTAGTAGAGATGGAGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCAGGCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCATGATCTCAGCT
Task1_train_26538
The following genetic variant occurs in LDLR (low density lipoprotein receptor) on Chromosome 19. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Hypercholesterolemia, familial, 1
ATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTGCAGGCGCCTGCCACTACGCCCGGCTACTTTTTTGTATATTTAGTAGAGATGGAGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCAGGCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCATGATCTCAGCTC
ATTTAGTGGGTAGAGGCTGGTGACGCTGCTGAACACCCAGAACAGGGAAGTAGCAGGCCCTAGATAGAGCCATCGTGGGGAAACCCTGCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCTTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTGCAGGCGCCTGCCACTACGCCCGGCTACTTTTTTGTATATTTAGTAGAGATGGAGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCAGGCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCATGATCTCAGCTC
Task1_train_26539
This alteration occurs within gene LDLR (low density lipoprotein receptor) located on Chromosome 19. Is it associated with a disease or is it a benign variant?
Pathogenic; Hypercholesterolemia, familial, 1
GCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTGCAGGCGCCTGCCACTACGCCCGGCTACTTTTTTGTATATTTAGTAGAGATGGAGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCAGGCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCATGATCTCAGCTCACTGCAAGCTCCACTTCCCAGGCTCACGCCATTCTCCAGCCTCAGCCTCCCAAGTAGCTGAGACTACAGGGGCCCGCCACCACACTC
GCTCTAAGGAAATGGCGCTATTTTATAACCCCACGTTCCTGGCATGATTACCAACAGCCAAAAGTGGAGTCCCCCCAAGTGTGTTCGTCCATTTGCATTGCAGTAAAGGAATAGCTGAGGCCGGGTAATTTATAAAGAAAAGAGATTTAAACTGGGTATGGCAGTTTATGCCTATAATCCCAGAACTTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGTCCAGGAGTGTGAGACCGAGACCAGCCTGGCCAACATGACGAAACTCTGTCTCTACAAAAAATACAAAAAGTAGGCCAGGCACGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACCGAGTTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAATACAAAAAGTAGCCAGGTGTGGTGGCAGGCACCTGTAATCCTGGGTTCTCGAGACCGAGGCATGAGAATTGCCTGACCCCAGGAGGTGGAGGCTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAGTGGGACTCTGTCTCAAAAAACAACAAAAAAAAAGTTCTGGAAATGGATGGTGGTGATGGTGATACTTCCACAACAGCGTGAATCTGCTTAAGGCCACCGAACTGTGCACTCACAAATAGTCGAGATGGTACATTTTATGTTATGTGTATTTCACCACAATTAAAAACTAGTTGTGGGCCAGGTGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAGAGGGAGGTGGATCATGAGGTCAGCAGTTCGAGACCAGCCAGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCTGGGAGGCTAAGATTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGACGACAGAGTGAGACTTCGTCTCAAAAAAAAAACCAAAAAAAAAATTAGCTGTGGGTCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGGTAGGTGGATGGCCTGAGGTCAGGAGTTCGAATCCAGCCTGGCCAACATGGTGAAAGCCCGTCTCTACTAAAAATACAAAAAATTAGTCAGGTATGTTGGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAAGCAAGAGAATCGTTTGAACCCAGGAGGTGGACGTTGCAGTGAGCCGAGATTGGGCCACTGTACTCCAGCCTGGGCAACAAAAGTGAAACTCTGTCTGAAACAAACAAACAAACAAACAAACAGACAAACAAAAAAACTAGTTGTGGAGAGAGGGTGGCCTGTGTCTCATCCCAGTGTTTAACGGGATTTGTCATCTTCCTTGCTGCCTGTTTAGGACAAAGTATTTTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGTAAGGGTGGGTCAGCCCCACCCCCCCAACCTTGAAACCTCCTTGTGGAAACTCTGGAATGTTCTGGAAATTTCTGGAATCTTCTGGTATAGCTGATGATCTCGTTCCTGCCCTGACTCCGCTTCTTCTGCCCCAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCGGCCTCACAGGTGTGGCACACGCCTTGTTTCTGCGTCCTGTGTCCTCCAACTGCCCCCTCCTGAGCCTCTCTCTGCTCATCTGTCAAATGGGTACCTCAAGGTCGTTGTAAGGACTCATGAGTCGGGATAACCATACTTTTCTTGGATGGACACATCAGCACCGGGCTTGACATTTACCCAGTTCCCCTTTGATGCCTGGTTTCCTCTTTCCCGGCCCCCTGAAGAGGTGATCTGATTTCTGACAGGAGCCCTGAGGGAGGAAATGGTCCCCTTTGTTGACTTTTCTTTTTCTTTATTTTTTTCTTTTGAGATTTGCTGTCACCCAGCCTGGAATGCAGTGGTGCCATCTTGGCTCACTGCTACCTCTCCCACTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCTGGCTAAGTTTTGTATTTTTAGTACAGACAGGGTTTCTCCATGGTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCTCCCACCTCTGCCTCCCGAAGTGCTACGATTACAGGCATGAGCCACCGCGCCCATCCCCCTTTGTTGACTTTTCTCATCCTCTGAGAAAGTCTCAGTTGAGGCCAGCACCTCCCTCAAGTGAATTGAATCTCCCTTTTGAACAACAACAAATAACAATATGACCCAGACGTGGTGGCTCACACCTGTGGTCCCAGCTACTCGGGAGGCTGAGGTGTGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTACAGAGAGCTATAATCACACCACTTCACTCCAGCCTGGGGGACAAAGTGAAACCCTGTCTGAAAAAAACAAAAAAAGAAAAAGGAAAAAGAAACAATACGATCACAAAGTAGATATTCATAGTGTTTATTTTCAGTACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAGCCTCTGCCTCCCAGGTTCAAGCGCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGCTTCTTCTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGGCACGTCCCACTACGCCCAGCTAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACTATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTTGGGCTCCCAAAGTGTTGGGATTATGGGCATGAGCCACTGCACCTGGCCTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGACATGAGCCACCGCGCCTGGCCGTGTCTGGCCTTTTTTAGTTATTTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTACTCCGTCGCCCAGGCTGGAGTGCAGCGGTGCGATGTCTGCGCACTGCAAGCTCCGCCCCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTGCAGGCGCCTGCCACTACGCCCGGCTACTTTTTTGTATATTTAGTAGAGATGGAGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCAGGCTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCATGATCTCAGCTCACTGCAAGCTCCACTTCCCAGGCTCACGCCATTCTCCAGCCTCAGCCTCCCAAGTAGCTGAGACTACAGGGGCCCGCCACCACACTC
Task1_train_26540
Chromosome 19 houses a mutation in gene LDLR (low density lipoprotein receptor). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Familial hypercholesterolemia
GCCTCCCAAAGTGTTGGGATTACAGGTGTGAGCCACCGCGCCCAGACCAAAATATGCTCATTTTAATAAAATGCACAAGTAGGTTGACAAGAATTTCACCTGCAACCTTGTCAACCACCTAGAATAAAAGCCTCTGCAGCCCTCCCCTAAAGACTCATCAATGTGAGGCTCAAGAACCTTCTTAGGCTGGGCTCGGTGGCTCATTTCTGTAATCCCTGCACTTTGGAAGGCTGAGGCAGGAGGATCTCTTGAGGCCAGGAGTTCAAGACAAGCCTGGGCAACATAGCCAGACCTCTGTTTCTATCCCCCACAAAAAGAACCTTCTTAAACCGGAATTGAGTCCTACAACCTCGATAACTCACAAATAAGCCCGTGTGGCCTCTCACAGACTTGGGAAGTTCTCCAAGTGTCCAGGGAGATGTGCCAGGCGCTTTCCTGCCGTGACCACCGTCCTCTGCCTGCTCCATTTCTTGGTGGCCTTCCTTTAGACCTGGGCCTCACTCTTGCTTCTCTCCTGCAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGGTAAGCGCGGGCCGGTCCCCCAGCGTCCCCCAGGTCACAGCCTCCCGCTATGTGACCTCGTGCCTGGCTGGTTGGGCCTGTTCACTTTTTCTCCTGGACAGGGAACAGCCCCACTGGTGTCCTTTATCACCCCCACGGCCTCTCCTGGCTTGGGGCTGACAGTGACAAGATCAGACAGCTAAGGGGTCAGATGGAGGATGTGGAGCTGGGTCCCGTGCTGTGGAATAGCCTCACCGAGATTTGAGTGCCTTCTGGGGAACTGGTTCCCTTGCAGGGGGCTGTGTGGAGAGGCGCGCTCTCCCTGCCTCACCCATGCTCATCCTAACTCGGTTACCATCACATCTCTTTTTTCTTTTTTTCTTAAATTTTAAGAAAAAAGAAATTTAATTTTTTTGAGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACCATCATGCCTCGCTGCAGCCTCAATGTCTGGGCTCAAGCGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGTGCAAGCCACTATACCCCACTTCCTATTTCTTAAAAAGTCACAGCCCTGTGTGTGGCTAATCCTGGACAGAAATCTAGAAGAAGTCAGCTACTTCTGGGGCGTGGCTCACCCAGTGGGCTTCAGGTTAGATATTTCTTATACTTATGAGGCTGGGTGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGTGGATTGCTTGGGCTCAGGAGTTCGAGACCAACCTGGGCAACATGGCGAAACCCTGTTTCTAGAAAAGGTACAAAAATTAGCTGGGCAGGTGGCACGTGCCTGTGGTACCAGCTACTTGAGGGCCTGAGGCAGGAGGATCGCTTGAACCTGGGAGGTCGAGGTTGCAGTGAACTGAGATCATGTCACTGCACTCCAGCCTGGTGACAGAGCAAGACCCCGTCTCAAAAAAAAAAAAAGAAAGAAAAAAATTCTTATGCATAGATTTGCCTCTTTTCTGTTTGTTTGTTTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCTCAACCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACTGACTGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTCTTGACCTCATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCAGGCCCAGGCCGCAAGGCGATCTCTAAACAAACATAAAAGACCAGGAGTCAAGGTTATGGTACGATGCCCGTGTTTTCACTCCAGCCACGGAGCTGGGTCTCTGGTCTCGGGGGCAGCTGTGTGACAGAGCGTGCCTCTCCCTACAGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGGTGAGTGACCCTCTCTAGAAAGCCAGAGCCCATGGCGGCCCCCTCCCAGCTGGAGGCATATGATCCTCAAGGGACCAGGCCGAGGCTTCCCCAGCCCTCCAGATCGAGGACAGCATTAGGTGAATGCTTCTGTGCGCTCATTCAGAATGTCAGCGGACAATGGCCTTGGTGGTGTAGAGGAATGTTGGATAAGCAAATAGAGAGCTCCATCAGATGGTGACAGGGCAAAGAAAGTCAAAAGGAGTTCAGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGGACTTTGGGAGGCCGAGGCTGGCGGATCACCTGAAGTCAGGAGTTTGAGACCAGCTTGGCCATCATGACAAAACCCCGTCTCTATTAAAAATACAAAAAATTAGCCAGGCGTGGGAGTGGGCGCCTGTAATCCCAGCTACTCGGGAGGCCGAGGTAGAAAAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCATTCCAGCCCGGGAGGCAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAGGAGTTCAGAGGCCCGGCATGGTGGTTCACACATGTGATCCCAGAACTTGGGGAGGTTGAGGCAGGAGAATCACCTGAGCTCAGAGTTCAAGACCAGCCTGGGCAGCACAGCAAGACCCCATCTCTGCAAAAAATAAAAATTTAGCCCAGTGTGGTGATGAGCGCCTAGTTCCAGCTACTAGGGAGGCTAAGGCAGGAGGATTGCTTGAGGCTAAGGTAGGAGATTGAGACTGCAGTGACTTGTGATTGCGTCACTGCGCTCCAGCCTGGGTGACAGAGCAAGCCCTTGTCTCTTAAAAAAAAAAAAAAATTCAAAGAAGGGTTTCCAGAGGGCCAGGAGGGAGGAAGGGAGAGGAGGTGTTTTATTTTTTTGCTTTTATTTTTTATTTTGAGACAGAGTCTCTCTCTGTCACCCAGGTTGGAGTGCAGTGCTGTGATCTTGGCTCACTGCAACTTCTGCCTCCTGGGTTCAAGCAATTCTTATGCCTCAGCCTCAGCCTCCTGAGTAGCTGGGATTACAACACTATGCCCGGGTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCGCCATGTTGCCCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTCCCCACGTGCTGGGATTGCAGGCGTGAGCCACTGCGCCCGCCTTGATCTTTACACAAGGGGTTTAGGGTAGGTAGCCTTCTCTGAACCAGGAGAACAGCCTGTGCGAAGGCCCTGAGGCTGGACCGTGCCTGTTGGGTTTGAGGCCGTTGTAGCTGGAGCAAACAGAGAGAGGGGTAAAAAGGCAGGAGGCTACCAGGCAGGTTGTGCAGAGCCTTGTGGGCCACTGGGGAGGACTTTGGCTTTTGCCCTGAGAGCGGTGGGAAGTGACTGAATCCGGTACTCACCGTCTCCCTCTGGCGGCTCCTGGGGGAACATGCTTGGGGATCAGGCTGGGGGAGGCTGCCAGGCCCAGGAGGTGAGAAGTAGGTGGCCTCCAGCCGTGTTTCCTGAATGCTGGACTGATAGTTTCCGCTGTTTACCATTTGTTGGCAGAGACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCCATTTCTCTCCAGGAAGTTTTGA
GCCTCCCAAAGTGTTGGGATTACAGGTGTGAGCCACCGCGCCCAGACCAAAATATGCTCATTTTAATAAAATGCACAAGTAGGTTGACAAGAATTTCACCTGCAACCTTGTCAACCACCTAGAATAAAAGCCTCTGCAGCCCTCCCCTAAAGACTCATCAATGTGAGGCTCAAGAACCTTCTTAGGCTGGGCTCGGTGGCTCATTTCTGTAATCCCTGCACTTTGGAAGGCTGAGGCAGGAGGATCTCTTGAGGCCAGGAGTTCAAGACAAGCCTGGGCAACATAGCCAGACCTCTGTTTCTATCCCCCACAAAAAGAACCTTCTTAAACCGGAATTGAGTCCTACAACCTCGATAACTCACAAATAAGCCCGTGTGGCCTCTCACAGACTTGGGAAGTTCTCCAAGTGTCCAGGGAGATGTGCCAGGCGCTTTCCTGCCGTGACCACCGTCCTCTGCCTGCTCCATTTCTTGGTGGCCTTCCTTTAGACCTGGGCCTCACTCTTGCTTCTCTCCTGCAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGGTAAGCGCGGGCCGGTCCCCCAGCGTCCCCCAGGTCACAGCCTCCCGCTATGTGACCTCGTGCCTGGCTGGTTGGGCCTGTTCACTTTTTCTCCTGGACAGGGAACAGCCCCACTGGTGTCCTTTATCACCCCCACGGCCTCTCCTGGCTTGGGGCTGACAGTGACAAGATCAGACAGCTAAGGGGTCAGATGGAGGATGTGGAGCTGGGTCCCGTGCTGTGGAATAGCCTCACCGAGATTTGAGTGCCTTCTGGGGAACTGGTTCCCTTGCAGGGGGCTGTGTGGAGAGGCGCGCTCTCCCTGCCTCACCCATGCTCATCCTAACTCGGTTACCATCACATCTCTTTTTTCTTTTTTTCTTAAATTTTAAGAAAAAAGAAATTTAATTTTTTTGAGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACCATCATGCCTCGCTGCAGCCTCAATGTCTGGGCTCAAGCGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGTGCAAGCCACTATACCCCACTTCCTATTTCTTAAAAAGTCACAGCCCTGTGTGTGGCTAATCCTGGACAGAAATCTAGAAGAAGTCAGCTACTTCTGGGGCGTGGCTCACCCAGTGGGCTTCAGGTTAGATATTTCTTATACTTATGAGGCTGGGTGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGTGGATTGCTTGGGCTCAGGAGTTCGAGACCAACCTGGGCAACATGGCGAAACCCTGTTTCTAGAAAAGGTACAAAAATTAGCTGGGCAGGTGGCACGTGCCTGTGGTACCAGCTACTTGAGGGCCTGAGGCAGGAGGATCGCTTGAACCTGGGAGGTCGAGGTTGCAGTGAACTGAGATCATGTCACTGCACTCCAGCCTGGTGACAGAGCAAGACCCCGTCTCAAAAAAAAAAAAAGAAAGAAAAAAATTCTTATGCATAGATTTGCCTCTTTTCTGTTTGTTTGTTTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCTCAACCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACTGACTGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTCTTGACCTCATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCAGGCCCAGGCCGCAAGGCGATCTCTAAACAAACATAAAAGACCAGGAGTCAAGGTTATGGTACGATGCCCGTGTTTTCACTCCAGCCACGGAGCTGGGTCTCTGGTCTCGGGGGCAGCTGTGTGACAGAGCGTGCCTCTCCCTACAGTGCTCCTCGTCTTCCTTTGCCTGCGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGGTGAGTGACCCTCTCTAGAAAGCCAGAGCCCATGGCGGCCCCCTCCCAGCTGGAGGCATATGATCCTCAAGGGACCAGGCCGAGGCTTCCCCAGCCCTCCAGATCGAGGACAGCATTAGGTGAATGCTTCTGTGCGCTCATTCAGAATGTCAGCGGACAATGGCCTTGGTGGTGTAGAGGAATGTTGGATAAGCAAATAGAGAGCTCCATCAGATGGTGACAGGGCAAAGAAAGTCAAAAGGAGTTCAGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGGACTTTGGGAGGCCGAGGCTGGCGGATCACCTGAAGTCAGGAGTTTGAGACCAGCTTGGCCATCATGACAAAACCCCGTCTCTATTAAAAATACAAAAAATTAGCCAGGCGTGGGAGTGGGCGCCTGTAATCCCAGCTACTCGGGAGGCCGAGGTAGAAAAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCATTCCAGCCCGGGAGGCAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAGGAGTTCAGAGGCCCGGCATGGTGGTTCACACATGTGATCCCAGAACTTGGGGAGGTTGAGGCAGGAGAATCACCTGAGCTCAGAGTTCAAGACCAGCCTGGGCAGCACAGCAAGACCCCATCTCTGCAAAAAATAAAAATTTAGCCCAGTGTGGTGATGAGCGCCTAGTTCCAGCTACTAGGGAGGCTAAGGCAGGAGGATTGCTTGAGGCTAAGGTAGGAGATTGAGACTGCAGTGACTTGTGATTGCGTCACTGCGCTCCAGCCTGGGTGACAGAGCAAGCCCTTGTCTCTTAAAAAAAAAAAAAAATTCAAAGAAGGGTTTCCAGAGGGCCAGGAGGGAGGAAGGGAGAGGAGGTGTTTTATTTTTTTGCTTTTATTTTTTATTTTGAGACAGAGTCTCTCTCTGTCACCCAGGTTGGAGTGCAGTGCTGTGATCTTGGCTCACTGCAACTTCTGCCTCCTGGGTTCAAGCAATTCTTATGCCTCAGCCTCAGCCTCCTGAGTAGCTGGGATTACAACACTATGCCCGGGTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCGCCATGTTGCCCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTCCCCACGTGCTGGGATTGCAGGCGTGAGCCACTGCGCCCGCCTTGATCTTTACACAAGGGGTTTAGGGTAGGTAGCCTTCTCTGAACCAGGAGAACAGCCTGTGCGAAGGCCCTGAGGCTGGACCGTGCCTGTTGGGTTTGAGGCCGTTGTAGCTGGAGCAAACAGAGAGAGGGGTAAAAAGGCAGGAGGCTACCAGGCAGGTTGTGCAGAGCCTTGTGGGCCACTGGGGAGGACTTTGGCTTTTGCCCTGAGAGCGGTGGGAAGTGACTGAATCCGGTACTCACCGTCTCCCTCTGGCGGCTCCTGGGGGAACATGCTTGGGGATCAGGCTGGGGGAGGCTGCCAGGCCCAGGAGGTGAGAAGTAGGTGGCCTCCAGCCGTGTTTCCTGAATGCTGGACTGATAGTTTCCGCTGTTTACCATTTGTTGGCAGAGACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCCATTTCTCTCCAGGAAGTTTTGA
Task1_train_26541
This mutation occurs in LDLR (low density lipoprotein receptor) on Chromosome 19. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Hypercholesterolemia, familial, 1
AGTGTTGGGATTACAGGTGTGAGCCACCGCGCCCAGACCAAAATATGCTCATTTTAATAAAATGCACAAGTAGGTTGACAAGAATTTCACCTGCAACCTTGTCAACCACCTAGAATAAAAGCCTCTGCAGCCCTCCCCTAAAGACTCATCAATGTGAGGCTCAAGAACCTTCTTAGGCTGGGCTCGGTGGCTCATTTCTGTAATCCCTGCACTTTGGAAGGCTGAGGCAGGAGGATCTCTTGAGGCCAGGAGTTCAAGACAAGCCTGGGCAACATAGCCAGACCTCTGTTTCTATCCCCCACAAAAAGAACCTTCTTAAACCGGAATTGAGTCCTACAACCTCGATAACTCACAAATAAGCCCGTGTGGCCTCTCACAGACTTGGGAAGTTCTCCAAGTGTCCAGGGAGATGTGCCAGGCGCTTTCCTGCCGTGACCACCGTCCTCTGCCTGCTCCATTTCTTGGTGGCCTTCCTTTAGACCTGGGCCTCACTCTTGCTTCTCTCCTGCAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGGTAAGCGCGGGCCGGTCCCCCAGCGTCCCCCAGGTCACAGCCTCCCGCTATGTGACCTCGTGCCTGGCTGGTTGGGCCTGTTCACTTTTTCTCCTGGACAGGGAACAGCCCCACTGGTGTCCTTTATCACCCCCACGGCCTCTCCTGGCTTGGGGCTGACAGTGACAAGATCAGACAGCTAAGGGGTCAGATGGAGGATGTGGAGCTGGGTCCCGTGCTGTGGAATAGCCTCACCGAGATTTGAGTGCCTTCTGGGGAACTGGTTCCCTTGCAGGGGGCTGTGTGGAGAGGCGCGCTCTCCCTGCCTCACCCATGCTCATCCTAACTCGGTTACCATCACATCTCTTTTTTCTTTTTTTCTTAAATTTTAAGAAAAAAGAAATTTAATTTTTTTGAGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACCATCATGCCTCGCTGCAGCCTCAATGTCTGGGCTCAAGCGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGTGCAAGCCACTATACCCCACTTCCTATTTCTTAAAAAGTCACAGCCCTGTGTGTGGCTAATCCTGGACAGAAATCTAGAAGAAGTCAGCTACTTCTGGGGCGTGGCTCACCCAGTGGGCTTCAGGTTAGATATTTCTTATACTTATGAGGCTGGGTGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGTGGATTGCTTGGGCTCAGGAGTTCGAGACCAACCTGGGCAACATGGCGAAACCCTGTTTCTAGAAAAGGTACAAAAATTAGCTGGGCAGGTGGCACGTGCCTGTGGTACCAGCTACTTGAGGGCCTGAGGCAGGAGGATCGCTTGAACCTGGGAGGTCGAGGTTGCAGTGAACTGAGATCATGTCACTGCACTCCAGCCTGGTGACAGAGCAAGACCCCGTCTCAAAAAAAAAAAAAGAAAGAAAAAAATTCTTATGCATAGATTTGCCTCTTTTCTGTTTGTTTGTTTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCTCAACCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACTGACTGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTCTTGACCTCATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCAGGCCCAGGCCGCAAGGCGATCTCTAAACAAACATAAAAGACCAGGAGTCAAGGTTATGGTACGATGCCCGTGTTTTCACTCCAGCCACGGAGCTGGGTCTCTGGTCTCGGGGGCAGCTGTGTGACAGAGCGTGCCTCTCCCTACAGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGGTGAGTGACCCTCTCTAGAAAGCCAGAGCCCATGGCGGCCCCCTCCCAGCTGGAGGCATATGATCCTCAAGGGACCAGGCCGAGGCTTCCCCAGCCCTCCAGATCGAGGACAGCATTAGGTGAATGCTTCTGTGCGCTCATTCAGAATGTCAGCGGACAATGGCCTTGGTGGTGTAGAGGAATGTTGGATAAGCAAATAGAGAGCTCCATCAGATGGTGACAGGGCAAAGAAAGTCAAAAGGAGTTCAGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGGACTTTGGGAGGCCGAGGCTGGCGGATCACCTGAAGTCAGGAGTTTGAGACCAGCTTGGCCATCATGACAAAACCCCGTCTCTATTAAAAATACAAAAAATTAGCCAGGCGTGGGAGTGGGCGCCTGTAATCCCAGCTACTCGGGAGGCCGAGGTAGAAAAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCATTCCAGCCCGGGAGGCAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAGGAGTTCAGAGGCCCGGCATGGTGGTTCACACATGTGATCCCAGAACTTGGGGAGGTTGAGGCAGGAGAATCACCTGAGCTCAGAGTTCAAGACCAGCCTGGGCAGCACAGCAAGACCCCATCTCTGCAAAAAATAAAAATTTAGCCCAGTGTGGTGATGAGCGCCTAGTTCCAGCTACTAGGGAGGCTAAGGCAGGAGGATTGCTTGAGGCTAAGGTAGGAGATTGAGACTGCAGTGACTTGTGATTGCGTCACTGCGCTCCAGCCTGGGTGACAGAGCAAGCCCTTGTCTCTTAAAAAAAAAAAAAAATTCAAAGAAGGGTTTCCAGAGGGCCAGGAGGGAGGAAGGGAGAGGAGGTGTTTTATTTTTTTGCTTTTATTTTTTATTTTGAGACAGAGTCTCTCTCTGTCACCCAGGTTGGAGTGCAGTGCTGTGATCTTGGCTCACTGCAACTTCTGCCTCCTGGGTTCAAGCAATTCTTATGCCTCAGCCTCAGCCTCCTGAGTAGCTGGGATTACAACACTATGCCCGGGTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCGCCATGTTGCCCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTCCCCACGTGCTGGGATTGCAGGCGTGAGCCACTGCGCCCGCCTTGATCTTTACACAAGGGGTTTAGGGTAGGTAGCCTTCTCTGAACCAGGAGAACAGCCTGTGCGAAGGCCCTGAGGCTGGACCGTGCCTGTTGGGTTTGAGGCCGTTGTAGCTGGAGCAAACAGAGAGAGGGGTAAAAAGGCAGGAGGCTACCAGGCAGGTTGTGCAGAGCCTTGTGGGCCACTGGGGAGGACTTTGGCTTTTGCCCTGAGAGCGGTGGGAAGTGACTGAATCCGGTACTCACCGTCTCCCTCTGGCGGCTCCTGGGGGAACATGCTTGGGGATCAGGCTGGGGGAGGCTGCCAGGCCCAGGAGGTGAGAAGTAGGTGGCCTCCAGCCGTGTTTCCTGAATGCTGGACTGATAGTTTCCGCTGTTTACCATTTGTTGGCAGAGACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCCATTTCTCTCCAGGAAGTTTTGAGTTTCTCTC
AGTGTTGGGATTACAGGTGTGAGCCACCGCGCCCAGACCAAAATATGCTCATTTTAATAAAATGCACAAGTAGGTTGACAAGAATTTCACCTGCAACCTTGTCAACCACCTAGAATAAAAGCCTCTGCAGCCCTCCCCTAAAGACTCATCAATGTGAGGCTCAAGAACCTTCTTAGGCTGGGCTCGGTGGCTCATTTCTGTAATCCCTGCACTTTGGAAGGCTGAGGCAGGAGGATCTCTTGAGGCCAGGAGTTCAAGACAAGCCTGGGCAACATAGCCAGACCTCTGTTTCTATCCCCCACAAAAAGAACCTTCTTAAACCGGAATTGAGTCCTACAACCTCGATAACTCACAAATAAGCCCGTGTGGCCTCTCACAGACTTGGGAAGTTCTCCAAGTGTCCAGGGAGATGTGCCAGGCGCTTTCCTGCCGTGACCACCGTCCTCTGCCTGCTCCATTTCTTGGTGGCCTTCCTTTAGACCTGGGCCTCACTCTTGCTTCTCTCCTGCAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGGTAAGCGCGGGCCGGTCCCCCAGCGTCCCCCAGGTCACAGCCTCCCGCTATGTGACCTCGTGCCTGGCTGGTTGGGCCTGTTCACTTTTTCTCCTGGACAGGGAACAGCCCCACTGGTGTCCTTTATCACCCCCACGGCCTCTCCTGGCTTGGGGCTGACAGTGACAAGATCAGACAGCTAAGGGGTCAGATGGAGGATGTGGAGCTGGGTCCCGTGCTGTGGAATAGCCTCACCGAGATTTGAGTGCCTTCTGGGGAACTGGTTCCCTTGCAGGGGGCTGTGTGGAGAGGCGCGCTCTCCCTGCCTCACCCATGCTCATCCTAACTCGGTTACCATCACATCTCTTTTTTCTTTTTTTCTTAAATTTTAAGAAAAAAGAAATTTAATTTTTTTGAGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACCATCATGCCTCGCTGCAGCCTCAATGTCTGGGCTCAAGCGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGTGCAAGCCACTATACCCCACTTCCTATTTCTTAAAAAGTCACAGCCCTGTGTGTGGCTAATCCTGGACAGAAATCTAGAAGAAGTCAGCTACTTCTGGGGCGTGGCTCACCCAGTGGGCTTCAGGTTAGATATTTCTTATACTTATGAGGCTGGGTGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGTGGATTGCTTGGGCTCAGGAGTTCGAGACCAACCTGGGCAACATGGCGAAACCCTGTTTCTAGAAAAGGTACAAAAATTAGCTGGGCAGGTGGCACGTGCCTGTGGTACCAGCTACTTGAGGGCCTGAGGCAGGAGGATCGCTTGAACCTGGGAGGTCGAGGTTGCAGTGAACTGAGATCATGTCACTGCACTCCAGCCTGGTGACAGAGCAAGACCCCGTCTCAAAAAAAAAAAAAGAAAGAAAAAAATTCTTATGCATAGATTTGCCTCTTTTCTGTTTGTTTGTTTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCTCAACCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACTGACTGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTCTTGACCTCATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCAGGCCCAGGCCGCAAGGCGATCTCTAAACAAACATAAAAGACCAGGAGTCAAGGTTATGGTACGATGCCCGTGTTTTCACTCCAGCCACGGAGCTGGGTCTCTGGTCTCGGGGGCAGCTGTGTGACAGAGCGTGCCTCTCCCTACAGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCGTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGGTGAGTGACCCTCTCTAGAAAGCCAGAGCCCATGGCGGCCCCCTCCCAGCTGGAGGCATATGATCCTCAAGGGACCAGGCCGAGGCTTCCCCAGCCCTCCAGATCGAGGACAGCATTAGGTGAATGCTTCTGTGCGCTCATTCAGAATGTCAGCGGACAATGGCCTTGGTGGTGTAGAGGAATGTTGGATAAGCAAATAGAGAGCTCCATCAGATGGTGACAGGGCAAAGAAAGTCAAAAGGAGTTCAGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGGACTTTGGGAGGCCGAGGCTGGCGGATCACCTGAAGTCAGGAGTTTGAGACCAGCTTGGCCATCATGACAAAACCCCGTCTCTATTAAAAATACAAAAAATTAGCCAGGCGTGGGAGTGGGCGCCTGTAATCCCAGCTACTCGGGAGGCCGAGGTAGAAAAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCATTCCAGCCCGGGAGGCAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAGGAGTTCAGAGGCCCGGCATGGTGGTTCACACATGTGATCCCAGAACTTGGGGAGGTTGAGGCAGGAGAATCACCTGAGCTCAGAGTTCAAGACCAGCCTGGGCAGCACAGCAAGACCCCATCTCTGCAAAAAATAAAAATTTAGCCCAGTGTGGTGATGAGCGCCTAGTTCCAGCTACTAGGGAGGCTAAGGCAGGAGGATTGCTTGAGGCTAAGGTAGGAGATTGAGACTGCAGTGACTTGTGATTGCGTCACTGCGCTCCAGCCTGGGTGACAGAGCAAGCCCTTGTCTCTTAAAAAAAAAAAAAAATTCAAAGAAGGGTTTCCAGAGGGCCAGGAGGGAGGAAGGGAGAGGAGGTGTTTTATTTTTTTGCTTTTATTTTTTATTTTGAGACAGAGTCTCTCTCTGTCACCCAGGTTGGAGTGCAGTGCTGTGATCTTGGCTCACTGCAACTTCTGCCTCCTGGGTTCAAGCAATTCTTATGCCTCAGCCTCAGCCTCCTGAGTAGCTGGGATTACAACACTATGCCCGGGTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCGCCATGTTGCCCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTCCCCACGTGCTGGGATTGCAGGCGTGAGCCACTGCGCCCGCCTTGATCTTTACACAAGGGGTTTAGGGTAGGTAGCCTTCTCTGAACCAGGAGAACAGCCTGTGCGAAGGCCCTGAGGCTGGACCGTGCCTGTTGGGTTTGAGGCCGTTGTAGCTGGAGCAAACAGAGAGAGGGGTAAAAAGGCAGGAGGCTACCAGGCAGGTTGTGCAGAGCCTTGTGGGCCACTGGGGAGGACTTTGGCTTTTGCCCTGAGAGCGGTGGGAAGTGACTGAATCCGGTACTCACCGTCTCCCTCTGGCGGCTCCTGGGGGAACATGCTTGGGGATCAGGCTGGGGGAGGCTGCCAGGCCCAGGAGGTGAGAAGTAGGTGGCCTCCAGCCGTGTTTCCTGAATGCTGGACTGATAGTTTCCGCTGTTTACCATTTGTTGGCAGAGACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCCATTTCTCTCCAGGAAGTTTTGAGTTTCTCTC
Task1_train_26542
A variant was discovered on Chromosome 19, affecting LDLR (low density lipoprotein receptor). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Hypercholesterolemia, familial, 1
TAATAAAATGCACAAGTAGGTTGACAAGAATTTCACCTGCAACCTTGTCAACCACCTAGAATAAAAGCCTCTGCAGCCCTCCCCTAAAGACTCATCAATGTGAGGCTCAAGAACCTTCTTAGGCTGGGCTCGGTGGCTCATTTCTGTAATCCCTGCACTTTGGAAGGCTGAGGCAGGAGGATCTCTTGAGGCCAGGAGTTCAAGACAAGCCTGGGCAACATAGCCAGACCTCTGTTTCTATCCCCCACAAAAAGAACCTTCTTAAACCGGAATTGAGTCCTACAACCTCGATAACTCACAAATAAGCCCGTGTGGCCTCTCACAGACTTGGGAAGTTCTCCAAGTGTCCAGGGAGATGTGCCAGGCGCTTTCCTGCCGTGACCACCGTCCTCTGCCTGCTCCATTTCTTGGTGGCCTTCCTTTAGACCTGGGCCTCACTCTTGCTTCTCTCCTGCAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGGTAAGCGCGGGCCGGTCCCCCAGCGTCCCCCAGGTCACAGCCTCCCGCTATGTGACCTCGTGCCTGGCTGGTTGGGCCTGTTCACTTTTTCTCCTGGACAGGGAACAGCCCCACTGGTGTCCTTTATCACCCCCACGGCCTCTCCTGGCTTGGGGCTGACAGTGACAAGATCAGACAGCTAAGGGGTCAGATGGAGGATGTGGAGCTGGGTCCCGTGCTGTGGAATAGCCTCACCGAGATTTGAGTGCCTTCTGGGGAACTGGTTCCCTTGCAGGGGGCTGTGTGGAGAGGCGCGCTCTCCCTGCCTCACCCATGCTCATCCTAACTCGGTTACCATCACATCTCTTTTTTCTTTTTTTCTTAAATTTTAAGAAAAAAGAAATTTAATTTTTTTGAGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACCATCATGCCTCGCTGCAGCCTCAATGTCTGGGCTCAAGCGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGTGCAAGCCACTATACCCCACTTCCTATTTCTTAAAAAGTCACAGCCCTGTGTGTGGCTAATCCTGGACAGAAATCTAGAAGAAGTCAGCTACTTCTGGGGCGTGGCTCACCCAGTGGGCTTCAGGTTAGATATTTCTTATACTTATGAGGCTGGGTGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGTGGATTGCTTGGGCTCAGGAGTTCGAGACCAACCTGGGCAACATGGCGAAACCCTGTTTCTAGAAAAGGTACAAAAATTAGCTGGGCAGGTGGCACGTGCCTGTGGTACCAGCTACTTGAGGGCCTGAGGCAGGAGGATCGCTTGAACCTGGGAGGTCGAGGTTGCAGTGAACTGAGATCATGTCACTGCACTCCAGCCTGGTGACAGAGCAAGACCCCGTCTCAAAAAAAAAAAAAGAAAGAAAAAAATTCTTATGCATAGATTTGCCTCTTTTCTGTTTGTTTGTTTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCTCAACCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACTGACTGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTCTTGACCTCATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCAGGCCCAGGCCGCAAGGCGATCTCTAAACAAACATAAAAGACCAGGAGTCAAGGTTATGGTACGATGCCCGTGTTTTCACTCCAGCCACGGAGCTGGGTCTCTGGTCTCGGGGGCAGCTGTGTGACAGAGCGTGCCTCTCCCTACAGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGGTGAGTGACCCTCTCTAGAAAGCCAGAGCCCATGGCGGCCCCCTCCCAGCTGGAGGCATATGATCCTCAAGGGACCAGGCCGAGGCTTCCCCAGCCCTCCAGATCGAGGACAGCATTAGGTGAATGCTTCTGTGCGCTCATTCAGAATGTCAGCGGACAATGGCCTTGGTGGTGTAGAGGAATGTTGGATAAGCAAATAGAGAGCTCCATCAGATGGTGACAGGGCAAAGAAAGTCAAAAGGAGTTCAGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGGACTTTGGGAGGCCGAGGCTGGCGGATCACCTGAAGTCAGGAGTTTGAGACCAGCTTGGCCATCATGACAAAACCCCGTCTCTATTAAAAATACAAAAAATTAGCCAGGCGTGGGAGTGGGCGCCTGTAATCCCAGCTACTCGGGAGGCCGAGGTAGAAAAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCATTCCAGCCCGGGAGGCAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAGGAGTTCAGAGGCCCGGCATGGTGGTTCACACATGTGATCCCAGAACTTGGGGAGGTTGAGGCAGGAGAATCACCTGAGCTCAGAGTTCAAGACCAGCCTGGGCAGCACAGCAAGACCCCATCTCTGCAAAAAATAAAAATTTAGCCCAGTGTGGTGATGAGCGCCTAGTTCCAGCTACTAGGGAGGCTAAGGCAGGAGGATTGCTTGAGGCTAAGGTAGGAGATTGAGACTGCAGTGACTTGTGATTGCGTCACTGCGCTCCAGCCTGGGTGACAGAGCAAGCCCTTGTCTCTTAAAAAAAAAAAAAAATTCAAAGAAGGGTTTCCAGAGGGCCAGGAGGGAGGAAGGGAGAGGAGGTGTTTTATTTTTTTGCTTTTATTTTTTATTTTGAGACAGAGTCTCTCTCTGTCACCCAGGTTGGAGTGCAGTGCTGTGATCTTGGCTCACTGCAACTTCTGCCTCCTGGGTTCAAGCAATTCTTATGCCTCAGCCTCAGCCTCCTGAGTAGCTGGGATTACAACACTATGCCCGGGTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCGCCATGTTGCCCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTCCCCACGTGCTGGGATTGCAGGCGTGAGCCACTGCGCCCGCCTTGATCTTTACACAAGGGGTTTAGGGTAGGTAGCCTTCTCTGAACCAGGAGAACAGCCTGTGCGAAGGCCCTGAGGCTGGACCGTGCCTGTTGGGTTTGAGGCCGTTGTAGCTGGAGCAAACAGAGAGAGGGGTAAAAAGGCAGGAGGCTACCAGGCAGGTTGTGCAGAGCCTTGTGGGCCACTGGGGAGGACTTTGGCTTTTGCCCTGAGAGCGGTGGGAAGTGACTGAATCCGGTACTCACCGTCTCCCTCTGGCGGCTCCTGGGGGAACATGCTTGGGGATCAGGCTGGGGGAGGCTGCCAGGCCCAGGAGGTGAGAAGTAGGTGGCCTCCAGCCGTGTTTCCTGAATGCTGGACTGATAGTTTCCGCTGTTTACCATTTGTTGGCAGAGACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCCATTTCTCTCCAGGAAGTTTTGAGTTTCTCTCCACCGTGACACAATCCTCAAACATGGAAGATGAAAGGGGAGGGGATGTCAGGCC
TAATAAAATGCACAAGTAGGTTGACAAGAATTTCACCTGCAACCTTGTCAACCACCTAGAATAAAAGCCTCTGCAGCCCTCCCCTAAAGACTCATCAATGTGAGGCTCAAGAACCTTCTTAGGCTGGGCTCGGTGGCTCATTTCTGTAATCCCTGCACTTTGGAAGGCTGAGGCAGGAGGATCTCTTGAGGCCAGGAGTTCAAGACAAGCCTGGGCAACATAGCCAGACCTCTGTTTCTATCCCCCACAAAAAGAACCTTCTTAAACCGGAATTGAGTCCTACAACCTCGATAACTCACAAATAAGCCCGTGTGGCCTCTCACAGACTTGGGAAGTTCTCCAAGTGTCCAGGGAGATGTGCCAGGCGCTTTCCTGCCGTGACCACCGTCCTCTGCCTGCTCCATTTCTTGGTGGCCTTCCTTTAGACCTGGGCCTCACTCTTGCTTCTCTCCTGCAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGGTAAGCGCGGGCCGGTCCCCCAGCGTCCCCCAGGTCACAGCCTCCCGCTATGTGACCTCGTGCCTGGCTGGTTGGGCCTGTTCACTTTTTCTCCTGGACAGGGAACAGCCCCACTGGTGTCCTTTATCACCCCCACGGCCTCTCCTGGCTTGGGGCTGACAGTGACAAGATCAGACAGCTAAGGGGTCAGATGGAGGATGTGGAGCTGGGTCCCGTGCTGTGGAATAGCCTCACCGAGATTTGAGTGCCTTCTGGGGAACTGGTTCCCTTGCAGGGGGCTGTGTGGAGAGGCGCGCTCTCCCTGCCTCACCCATGCTCATCCTAACTCGGTTACCATCACATCTCTTTTTTCTTTTTTTCTTAAATTTTAAGAAAAAAGAAATTTAATTTTTTTGAGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACCATCATGCCTCGCTGCAGCCTCAATGTCTGGGCTCAAGCGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGTGCAAGCCACTATACCCCACTTCCTATTTCTTAAAAAGTCACAGCCCTGTGTGTGGCTAATCCTGGACAGAAATCTAGAAGAAGTCAGCTACTTCTGGGGCGTGGCTCACCCAGTGGGCTTCAGGTTAGATATTTCTTATACTTATGAGGCTGGGTGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGTGGATTGCTTGGGCTCAGGAGTTCGAGACCAACCTGGGCAACATGGCGAAACCCTGTTTCTAGAAAAGGTACAAAAATTAGCTGGGCAGGTGGCACGTGCCTGTGGTACCAGCTACTTGAGGGCCTGAGGCAGGAGGATCGCTTGAACCTGGGAGGTCGAGGTTGCAGTGAACTGAGATCATGTCACTGCACTCCAGCCTGGTGACAGAGCAAGACCCCGTCTCAAAAAAAAAAAAAGAAAGAAAAAAATTCTTATGCATAGATTTGCCTCTTTTCTGTTTGTTTGTTTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCTCAACCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACTGACTGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTCTTGACCTCATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCAGGCCCAGGCCGCAAGGCGATCTCTAAACAAACATAAAAGACCAGGAGTCAAGGTTATGGTACGATGCCCGTGTTTTCACTCCAGCCACGGAGCTGGGTCTCTGGTCTCGGGGGCAGCTGTGTGACAGAGCGTGCCTCTCCCTACAGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACTCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGGTGAGTGACCCTCTCTAGAAAGCCAGAGCCCATGGCGGCCCCCTCCCAGCTGGAGGCATATGATCCTCAAGGGACCAGGCCGAGGCTTCCCCAGCCCTCCAGATCGAGGACAGCATTAGGTGAATGCTTCTGTGCGCTCATTCAGAATGTCAGCGGACAATGGCCTTGGTGGTGTAGAGGAATGTTGGATAAGCAAATAGAGAGCTCCATCAGATGGTGACAGGGCAAAGAAAGTCAAAAGGAGTTCAGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGGACTTTGGGAGGCCGAGGCTGGCGGATCACCTGAAGTCAGGAGTTTGAGACCAGCTTGGCCATCATGACAAAACCCCGTCTCTATTAAAAATACAAAAAATTAGCCAGGCGTGGGAGTGGGCGCCTGTAATCCCAGCTACTCGGGAGGCCGAGGTAGAAAAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCATTCCAGCCCGGGAGGCAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAGGAGTTCAGAGGCCCGGCATGGTGGTTCACACATGTGATCCCAGAACTTGGGGAGGTTGAGGCAGGAGAATCACCTGAGCTCAGAGTTCAAGACCAGCCTGGGCAGCACAGCAAGACCCCATCTCTGCAAAAAATAAAAATTTAGCCCAGTGTGGTGATGAGCGCCTAGTTCCAGCTACTAGGGAGGCTAAGGCAGGAGGATTGCTTGAGGCTAAGGTAGGAGATTGAGACTGCAGTGACTTGTGATTGCGTCACTGCGCTCCAGCCTGGGTGACAGAGCAAGCCCTTGTCTCTTAAAAAAAAAAAAAAATTCAAAGAAGGGTTTCCAGAGGGCCAGGAGGGAGGAAGGGAGAGGAGGTGTTTTATTTTTTTGCTTTTATTTTTTATTTTGAGACAGAGTCTCTCTCTGTCACCCAGGTTGGAGTGCAGTGCTGTGATCTTGGCTCACTGCAACTTCTGCCTCCTGGGTTCAAGCAATTCTTATGCCTCAGCCTCAGCCTCCTGAGTAGCTGGGATTACAACACTATGCCCGGGTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCGCCATGTTGCCCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTCCCCACGTGCTGGGATTGCAGGCGTGAGCCACTGCGCCCGCCTTGATCTTTACACAAGGGGTTTAGGGTAGGTAGCCTTCTCTGAACCAGGAGAACAGCCTGTGCGAAGGCCCTGAGGCTGGACCGTGCCTGTTGGGTTTGAGGCCGTTGTAGCTGGAGCAAACAGAGAGAGGGGTAAAAAGGCAGGAGGCTACCAGGCAGGTTGTGCAGAGCCTTGTGGGCCACTGGGGAGGACTTTGGCTTTTGCCCTGAGAGCGGTGGGAAGTGACTGAATCCGGTACTCACCGTCTCCCTCTGGCGGCTCCTGGGGGAACATGCTTGGGGATCAGGCTGGGGGAGGCTGCCAGGCCCAGGAGGTGAGAAGTAGGTGGCCTCCAGCCGTGTTTCCTGAATGCTGGACTGATAGTTTCCGCTGTTTACCATTTGTTGGCAGAGACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCCATTTCTCTCCAGGAAGTTTTGAGTTTCTCTCCACCGTGACACAATCCTCAAACATGGAAGATGAAAGGGGAGGGGATGTCAGGCC
Task1_train_26543
This variant impacts the gene LDLR (low density lipoprotein receptor) on Chromosome 19. Is the change likely to result in a pathogenic outcome?
Pathogenic; Hypercholesterolemia, familial, 1
ACAAGTAGGTTGACAAGAATTTCACCTGCAACCTTGTCAACCACCTAGAATAAAAGCCTCTGCAGCCCTCCCCTAAAGACTCATCAATGTGAGGCTCAAGAACCTTCTTAGGCTGGGCTCGGTGGCTCATTTCTGTAATCCCTGCACTTTGGAAGGCTGAGGCAGGAGGATCTCTTGAGGCCAGGAGTTCAAGACAAGCCTGGGCAACATAGCCAGACCTCTGTTTCTATCCCCCACAAAAAGAACCTTCTTAAACCGGAATTGAGTCCTACAACCTCGATAACTCACAAATAAGCCCGTGTGGCCTCTCACAGACTTGGGAAGTTCTCCAAGTGTCCAGGGAGATGTGCCAGGCGCTTTCCTGCCGTGACCACCGTCCTCTGCCTGCTCCATTTCTTGGTGGCCTTCCTTTAGACCTGGGCCTCACTCTTGCTTCTCTCCTGCAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGGTAAGCGCGGGCCGGTCCCCCAGCGTCCCCCAGGTCACAGCCTCCCGCTATGTGACCTCGTGCCTGGCTGGTTGGGCCTGTTCACTTTTTCTCCTGGACAGGGAACAGCCCCACTGGTGTCCTTTATCACCCCCACGGCCTCTCCTGGCTTGGGGCTGACAGTGACAAGATCAGACAGCTAAGGGGTCAGATGGAGGATGTGGAGCTGGGTCCCGTGCTGTGGAATAGCCTCACCGAGATTTGAGTGCCTTCTGGGGAACTGGTTCCCTTGCAGGGGGCTGTGTGGAGAGGCGCGCTCTCCCTGCCTCACCCATGCTCATCCTAACTCGGTTACCATCACATCTCTTTTTTCTTTTTTTCTTAAATTTTAAGAAAAAAGAAATTTAATTTTTTTGAGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACCATCATGCCTCGCTGCAGCCTCAATGTCTGGGCTCAAGCGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGTGCAAGCCACTATACCCCACTTCCTATTTCTTAAAAAGTCACAGCCCTGTGTGTGGCTAATCCTGGACAGAAATCTAGAAGAAGTCAGCTACTTCTGGGGCGTGGCTCACCCAGTGGGCTTCAGGTTAGATATTTCTTATACTTATGAGGCTGGGTGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGTGGATTGCTTGGGCTCAGGAGTTCGAGACCAACCTGGGCAACATGGCGAAACCCTGTTTCTAGAAAAGGTACAAAAATTAGCTGGGCAGGTGGCACGTGCCTGTGGTACCAGCTACTTGAGGGCCTGAGGCAGGAGGATCGCTTGAACCTGGGAGGTCGAGGTTGCAGTGAACTGAGATCATGTCACTGCACTCCAGCCTGGTGACAGAGCAAGACCCCGTCTCAAAAAAAAAAAAAGAAAGAAAAAAATTCTTATGCATAGATTTGCCTCTTTTCTGTTTGTTTGTTTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCTCAACCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACTGACTGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTCTTGACCTCATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCAGGCCCAGGCCGCAAGGCGATCTCTAAACAAACATAAAAGACCAGGAGTCAAGGTTATGGTACGATGCCCGTGTTTTCACTCCAGCCACGGAGCTGGGTCTCTGGTCTCGGGGGCAGCTGTGTGACAGAGCGTGCCTCTCCCTACAGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGGTGAGTGACCCTCTCTAGAAAGCCAGAGCCCATGGCGGCCCCCTCCCAGCTGGAGGCATATGATCCTCAAGGGACCAGGCCGAGGCTTCCCCAGCCCTCCAGATCGAGGACAGCATTAGGTGAATGCTTCTGTGCGCTCATTCAGAATGTCAGCGGACAATGGCCTTGGTGGTGTAGAGGAATGTTGGATAAGCAAATAGAGAGCTCCATCAGATGGTGACAGGGCAAAGAAAGTCAAAAGGAGTTCAGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGGACTTTGGGAGGCCGAGGCTGGCGGATCACCTGAAGTCAGGAGTTTGAGACCAGCTTGGCCATCATGACAAAACCCCGTCTCTATTAAAAATACAAAAAATTAGCCAGGCGTGGGAGTGGGCGCCTGTAATCCCAGCTACTCGGGAGGCCGAGGTAGAAAAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCATTCCAGCCCGGGAGGCAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAGGAGTTCAGAGGCCCGGCATGGTGGTTCACACATGTGATCCCAGAACTTGGGGAGGTTGAGGCAGGAGAATCACCTGAGCTCAGAGTTCAAGACCAGCCTGGGCAGCACAGCAAGACCCCATCTCTGCAAAAAATAAAAATTTAGCCCAGTGTGGTGATGAGCGCCTAGTTCCAGCTACTAGGGAGGCTAAGGCAGGAGGATTGCTTGAGGCTAAGGTAGGAGATTGAGACTGCAGTGACTTGTGATTGCGTCACTGCGCTCCAGCCTGGGTGACAGAGCAAGCCCTTGTCTCTTAAAAAAAAAAAAAAATTCAAAGAAGGGTTTCCAGAGGGCCAGGAGGGAGGAAGGGAGAGGAGGTGTTTTATTTTTTTGCTTTTATTTTTTATTTTGAGACAGAGTCTCTCTCTGTCACCCAGGTTGGAGTGCAGTGCTGTGATCTTGGCTCACTGCAACTTCTGCCTCCTGGGTTCAAGCAATTCTTATGCCTCAGCCTCAGCCTCCTGAGTAGCTGGGATTACAACACTATGCCCGGGTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCGCCATGTTGCCCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTCCCCACGTGCTGGGATTGCAGGCGTGAGCCACTGCGCCCGCCTTGATCTTTACACAAGGGGTTTAGGGTAGGTAGCCTTCTCTGAACCAGGAGAACAGCCTGTGCGAAGGCCCTGAGGCTGGACCGTGCCTGTTGGGTTTGAGGCCGTTGTAGCTGGAGCAAACAGAGAGAGGGGTAAAAAGGCAGGAGGCTACCAGGCAGGTTGTGCAGAGCCTTGTGGGCCACTGGGGAGGACTTTGGCTTTTGCCCTGAGAGCGGTGGGAAGTGACTGAATCCGGTACTCACCGTCTCCCTCTGGCGGCTCCTGGGGGAACATGCTTGGGGATCAGGCTGGGGGAGGCTGCCAGGCCCAGGAGGTGAGAAGTAGGTGGCCTCCAGCCGTGTTTCCTGAATGCTGGACTGATAGTTTCCGCTGTTTACCATTTGTTGGCAGAGACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCCATTTCTCTCCAGGAAGTTTTGAGTTTCTCTCCACCGTGACACAATCCTCAAACATGGAAGATGAAAGGGGAGGGGATGTCAGGCCCAGAGAAGCAA
ACAAGTAGGTTGACAAGAATTTCACCTGCAACCTTGTCAACCACCTAGAATAAAAGCCTCTGCAGCCCTCCCCTAAAGACTCATCAATGTGAGGCTCAAGAACCTTCTTAGGCTGGGCTCGGTGGCTCATTTCTGTAATCCCTGCACTTTGGAAGGCTGAGGCAGGAGGATCTCTTGAGGCCAGGAGTTCAAGACAAGCCTGGGCAACATAGCCAGACCTCTGTTTCTATCCCCCACAAAAAGAACCTTCTTAAACCGGAATTGAGTCCTACAACCTCGATAACTCACAAATAAGCCCGTGTGGCCTCTCACAGACTTGGGAAGTTCTCCAAGTGTCCAGGGAGATGTGCCAGGCGCTTTCCTGCCGTGACCACCGTCCTCTGCCTGCTCCATTTCTTGGTGGCCTTCCTTTAGACCTGGGCCTCACTCTTGCTTCTCTCCTGCAGCTCTGGGCGACGTTGCTGGCAGAGGAAATGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGGTAAGCGCGGGCCGGTCCCCCAGCGTCCCCCAGGTCACAGCCTCCCGCTATGTGACCTCGTGCCTGGCTGGTTGGGCCTGTTCACTTTTTCTCCTGGACAGGGAACAGCCCCACTGGTGTCCTTTATCACCCCCACGGCCTCTCCTGGCTTGGGGCTGACAGTGACAAGATCAGACAGCTAAGGGGTCAGATGGAGGATGTGGAGCTGGGTCCCGTGCTGTGGAATAGCCTCACCGAGATTTGAGTGCCTTCTGGGGAACTGGTTCCCTTGCAGGGGGCTGTGTGGAGAGGCGCGCTCTCCCTGCCTCACCCATGCTCATCCTAACTCGGTTACCATCACATCTCTTTTTTCTTTTTTTCTTAAATTTTAAGAAAAAAGAAATTTAATTTTTTTGAGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACCATCATGCCTCGCTGCAGCCTCAATGTCTGGGCTCAAGCGATCCTCCCACCTCAGCCTCCTGAGTAGCTGGTGCAAGCCACTATACCCCACTTCCTATTTCTTAAAAAGTCACAGCCCTGTGTGTGGCTAATCCTGGACAGAAATCTAGAAGAAGTCAGCTACTTCTGGGGCGTGGCTCACCCAGTGGGCTTCAGGTTAGATATTTCTTATACTTATGAGGCTGGGTGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGTGGATTGCTTGGGCTCAGGAGTTCGAGACCAACCTGGGCAACATGGCGAAACCCTGTTTCTAGAAAAGGTACAAAAATTAGCTGGGCAGGTGGCACGTGCCTGTGGTACCAGCTACTTGAGGGCCTGAGGCAGGAGGATCGCTTGAACCTGGGAGGTCGAGGTTGCAGTGAACTGAGATCATGTCACTGCACTCCAGCCTGGTGACAGAGCAAGACCCCGTCTCAAAAAAAAAAAAAGAAAGAAAAAAATTCTTATGCATAGATTTGCCTCTTTTCTGTTTGTTTGTTTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCTCAACCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACTGACTGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTCTTGACCTCATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCAGGCCCAGGCCGCAAGGCGATCTCTAAACAAACATAAAAGACCAGGAGTCAAGGTTATGGTACGATGCCCGTGTTTTCACTCCAGCCACGGAGCTGGGTCTCTGGTCTCGGGGGCAGCTGTGTGACAGAGCGTGCCTCTCCCTACAGTGCTCCTCGTCTTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCACAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTCGGTGAGTGACCCTCTCTAGAAAGCCAGAGCCCATGGCGGCCCCCTCCCAGCTGGAGGCATATGATCCTCAAGGGACCAGGCCGAGGCTTCCCCAGCCCTCCAGATCGAGGACAGCATTAGGTGAATGCTTCTGTGCGCTCATTCAGAATGTCAGCGGACAATGGCCTTGGTGGTGTAGAGGAATGTTGGATAAGCAAATAGAGAGCTCCATCAGATGGTGACAGGGCAAAGAAAGTCAAAAGGAGTTCAGAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGGACTTTGGGAGGCCGAGGCTGGCGGATCACCTGAAGTCAGGAGTTTGAGACCAGCTTGGCCATCATGACAAAACCCCGTCTCTATTAAAAATACAAAAAATTAGCCAGGCGTGGGAGTGGGCGCCTGTAATCCCAGCTACTCGGGAGGCCGAGGTAGAAAAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCCACTGCATTCCAGCCCGGGAGGCAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAGGAGTTCAGAGGCCCGGCATGGTGGTTCACACATGTGATCCCAGAACTTGGGGAGGTTGAGGCAGGAGAATCACCTGAGCTCAGAGTTCAAGACCAGCCTGGGCAGCACAGCAAGACCCCATCTCTGCAAAAAATAAAAATTTAGCCCAGTGTGGTGATGAGCGCCTAGTTCCAGCTACTAGGGAGGCTAAGGCAGGAGGATTGCTTGAGGCTAAGGTAGGAGATTGAGACTGCAGTGACTTGTGATTGCGTCACTGCGCTCCAGCCTGGGTGACAGAGCAAGCCCTTGTCTCTTAAAAAAAAAAAAAAATTCAAAGAAGGGTTTCCAGAGGGCCAGGAGGGAGGAAGGGAGAGGAGGTGTTTTATTTTTTTGCTTTTATTTTTTATTTTGAGACAGAGTCTCTCTCTGTCACCCAGGTTGGAGTGCAGTGCTGTGATCTTGGCTCACTGCAACTTCTGCCTCCTGGGTTCAAGCAATTCTTATGCCTCAGCCTCAGCCTCCTGAGTAGCTGGGATTACAACACTATGCCCGGGTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCGCCATGTTGCCCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTCCCCACGTGCTGGGATTGCAGGCGTGAGCCACTGCGCCCGCCTTGATCTTTACACAAGGGGTTTAGGGTAGGTAGCCTTCTCTGAACCAGGAGAACAGCCTGTGCGAAGGCCCTGAGGCTGGACCGTGCCTGTTGGGTTTGAGGCCGTTGTAGCTGGAGCAAACAGAGAGAGGGGTAAAAAGGCAGGAGGCTACCAGGCAGGTTGTGCAGAGCCTTGTGGGCCACTGGGGAGGACTTTGGCTTTTGCCCTGAGAGCGGTGGGAAGTGACTGAATCCGGTACTCACCGTCTCCCTCTGGCGGCTCCTGGGGGAACATGCTTGGGGATCAGGCTGGGGGAGGCTGCCAGGCCCAGGAGGTGAGAAGTAGGTGGCCTCCAGCCGTGTTTCCTGAATGCTGGACTGATAGTTTCCGCTGTTTACCATTTGTTGGCAGAGACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAACCCTTCCTGAGACCTCGCCGGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAGCTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGGGTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGACACCTCCATTTCTCTCCAGGAAGTTTTGAGTTTCTCTCCACCGTGACACAATCCTCAAACATGGAAGATGAAAGGGGAGGGGATGTCAGGCCCAGAGAAGCAA
Task1_train_26544
A change on Chromosome 19 affects gene KANK2 (KN motif and ankyrin repeat domains 2). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Nephrotic syndrome 16
TTTTGCCCAGACACCTGTTCATAAGCCCCAGTCACCTCCACAGTGCCTGTTTCTGCTTCCCAACACACAGCTGAAGGGAGCGCTCAAACCAGGAATCAGGCCACGCCACTTCCCTGCCTAAATTCCCCTGGCGGTTTCCTGCAGCCCTGAGTCCAAACTGGCTTGAGTCCCGGTGCTCCCTAAAATGCTTATGGCTTGAAGAACGGGCTAGTGAGCTTCAGGAGACCATGCCTGCTTGTTCGCCATTTCAGTCCCCAGTTTTCGGCCCAGGGAACCCAGCTGCTGCTCAATGAACTGTCCAGCAGGATGTGGGATGGGGTCATATTAAGAAAGGTAAGGACCCTCATATCCTCTACTCCTTCTAGTTTCCACAAGAAGGTCCTGTGTCAGAGACAGCCTGGCCATGAAGAGCAGGGCTCTGGAGTTAGACCACCTGGGTTTGGGCCTGTCACTCAGCTGGGATGTCATAAAGTAGGAAGAGCCACCTGGATCTGCAGCAGCCGGGGTCCCCATACCTGGCTGGCTTTGGCATTGATGTTGCCAAGCCGGAAGAGCTGAAGGACAGTCTCGATGTCGTCCTGGGTCTTCAGGGTGGCCAGGGCGGTGAGCATAATAGGGCTGTAGCCAGCACGGTTCTGTTTGTCCACCTTGCAGACACCTAAGAGACATGGTGTGAACCCTCAGACCAGGGATCGCTGCTAGTGGACTGCCCCAAGGAACGTGGATACCACGTCTCGTCCATCAGTCTAGGCATGCCCTAATCCCTCCCTTTTCTCAGAGGACCCCACTCTGCCCTAGAGGTCTCCATCTCCATTAGACCTGGGGCTCCTAAAGTTGGAGACAGTTCCTCCTCCATCAGATTTGGGGCCCCTGATGCTGGCATCTATATTTAGGGCTGAGAATAGAAACTGGGTCTCCCCTGTTAATTTTGGAACAGCCATTTACCCTCAGACTGGCCCATGTCTCCCCCATCAGATTGTGGGCCCTGAGTCCTTCATCAGCCCGGGAGGCTGTCTCCCCCAGTAGGAGAGGGAAGGGCAAGTTTCTTACTAACTGAGGACCACGTCTTCTTTCCAAGCCCCAGACTTGAGGACGCATCCCTCTCTTAGACCAGGGCTCCAGAGATGTCACCTCCATCATGCAGGCGTGTTAGGTTCACACGTTTCCCTAACATCACTTCTGCCTTTTCCATTATGCTGGCTAAAGGTAGGGCCCGTGCCTCCCCCACCAGACTGGGAAGGAAGTGTCTCCTCCATCAGACTGGGAGGACAGCATCTCCCCCATAAGACCAGGAGGGTAGAGTCTCTGCTATCAGACTAGGAGAGTCATGTCTCCCTCGTTAGACTGGGAAGGTGGTGTCTCACTCATTAGACTAGGAGGGTGGTGTCTCTGCCATTTGACTGGGAAGACAGCGTCTCCTCTATCAGACTGGGAGGGCCACATTCCCCCAACAATGAACCGGGAAGATGATGTCTCCTCCATTAAACTAGGCAGGTGGTGTCTCCTCCATCAGCCTGGGAGGGTGGTGCCCCCCCCATCAGACTGGAAGGGTGGCATCTCCCATATCAAACTGGGAAAGTCACATTTCCCCCATCAGACTGGGGAGGCAGCATCTCCTCCATCAGACTAGGAGGGCCACATCCCCACCACAATGAACTGGGAAGGTGTCTCCTCCATCAGCCTGGGAGGGTGGCATCTCCTCCATCAGACTGGGAGGGCGGCATCTCCTCCATCAGACTGGGAGGGCCATATACCCCACCCCATTGAACTGGGAAGGTGCCGTCTCCTCTATCAAACTGGAAGGCTGGTGTCCCTCCACATCCAATCGGAAGGTGGCATCTGCCACATCAGACTGGGAGAGAGGTGTTCCCTCTATTATACTGAGAAGGCCGCGTCTCCTCCATCATCTTCCCCATCAGATGGGGAGGGCAGTGTCTTCCCTATCAGACTGGGCATGGCGGACAGCTGGCTGGTTTAGAGCCGCCTCGTCCTCCCCGCTGGGCTCACCGCTGTCGAGCAGCTGCTGCACCACGGGGAAGTTGGCATGAGACACGGAGTAGTGCAGGGCTGTGTTGCCGTTGCTGTCGGCGATGTTGACCACGTAGTCCAGCAGCCGCGCAGACATGGCCCGGAACGTGACCAGGTGCCGCCGCACCAGCTCGGGGTGTGCGTCGCTGCGGCAGGCCAGGCGCAGCCACTCCTGCAGCACTGTGGTGTAGGCCACTTTCTGCATGCGAGTCAGGTGGGAGAGGATGTGAGGGCGGGGGAGGCCCACTGGGACACCCCCCACCCCAGATGCGCCCCCGGAGCAAAGCGTGGTGCCCTTGTCCTGGAAAACGATCTCAAGGGAAGTGCAGACCCTCCCAAAGGGAAGTGTAGACATCTCTGTCCCAATAAGACCCTTGGAGTGAGGTGTGGACTTTGCAATCCCCAACACGTTCCCCAAGGAAGGTGTGAGCACCTCCACCCTGGATATAATTTCTCTCTCTCTCTTTTTTTTTTTTTTTTGTGAGACAGAGTCTCGCTCTGTTGCCTAGGCTGGAGTGCAGTTACATGATCAGGACTCACTGCAGCCTCAACCTCCTAGGCTCAAGCTATCCTCCCGCCTCTGCCTCCCAAGTAGCTGGGACCACAGGCGTGCACCACTATGCCTAGCTAATTTTTAAAACAATTTGTAGAGGCTGAGTGCAGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAGGGTGAGCGGATCACTTGAGGTCACGAGTTCGAGACCATCCTGCCCAACATGGTGAAACCCCATCTCTACTCAAAATACAAAAAATTAGCCAGACGTGGTGGCACATGCCTATAGTCCCAGCTACTTGGGAGGTTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTACAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCCTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAATTTTTTTGTAGAAATGGGGTCTCACTATGTTGCCCAGGCTGGTCTTGAACTCCTGGCCTCAAGCGATCCTCCTGCCTTGGCCTCCCAAAGCACCAGGATGACAGGCATGAGCCACTGCGCCCAGCCCTGGTTATAATCGCCAAAGTCAAGTGTAGATGCCCAAAAAGGGAAATCTGGGTGCCCCGCCCCTGAAGCCCCCAGGAAGAACAGGAACCCAAGGCCAGGCTTGGCCAGTGAGTGTTCATCCTCCAGCCTCTCCCCATCTCCCTGGCCTCTCTCCGAGGCCCATGACTTGAGCACCACCACCCCCATGCTCTGGGCTTCAGTGTCAGGGTCCCCACTAGGCAGGAGCAGGAAGTCACTGAGGATGAGGAGAGGCCACGGGTGGGGTGGAGGTAGGGGTCCGGGGGGTGGCCAACCTAGGCCCAGGGCCAGATCGTACCAGCTCCCGCTCTGTGAGGGCGTTGGGATTGTCCAGGTACTTTTCCAGGGCCAAGCAGGCTGAGATGAGGTCAGGGCTTAGCTCCATCCTGCCAGGAACAGACAAAGCGGGGAACTAAGTAAGCCCCGCTGCGGTGCCTGGGAAGGGACTTGACATTCTGCACCACGTCACTCACAATAGGGTCACCTGAATGGTGGCATCTCAGACCCTCCTTCACCCGGGACACACATTTACATTGCACCCCAAGGGGCAGCTGTGGGGAACATGCAGACCCCCAAGGGAGAGTGGACACACAAGCCAAAGTTTATTCCAAATGCCCACTGGCAGATGGAAAATATTTCCCAAGGGCAAATTTTTTCACCAGGGGAATAAAAAAGAGACATAAATAGAACAGACAGGTAGAGGAAACGTCCCAAAGTAGGTGGGTGATTTTGGGATAAACTTTGGCTGGTCCCCTAAATCCTAACCCCGGCAGCCCAAAATAGTTCCACCAGGCCCTTTAGCAAAGCCTCCAGAACTTCAGATGCCCAGAAGGAGCAAGTGCTCGTTTGCTAATTCAGACTAAAGTGTGCATGACTGATAGGAGGGTCCTTCAAAGGGCTTGAACGGTGGGGGTTTGAGGCAGAGGTCATCCACCCCCGGCCCTGCCTGAATCCCTCC
TTTTGCCCAGACACCTGTTCATAAGCCCCAGTCACCTCCACAGTGCCTGTTTCTGCTTCCCAACACACAGCTGAAGGGAGCGCTCAAACCAGGAATCAGGCCACGCCACTTCCCTGCCTAAATTCCCCTGGCGGTTTCCTGCAGCCCTGAGTCCAAACTGGCTTGAGTCCCGGTGCTCCCTAAAATGCTTATGGCTTGAAGAACGGGCTAGTGAGCTTCAGGAGACCATGCCTGCTTGTTCGCCATTTCAGTCCCCAGTTTTCGGCCCAGGGAACCCAGCTGCTGCTCAATGAACTGTCCAGCAGGATGTGGGATGGGGTCATATTAAGAAAGGTAAGGACCCTCATATCCTCTACTCCTTCTAGTTTCCACAAGAAGGTCCTGTGTCAGAGACAGCCTGGCCATGAAGAGCAGGGCTCTGGAGTTAGACCACCTGGGTTTGGGCCTGTCACTCAGCTGGGATGTCATAAAGTAGGAAGAGCCACCTGGATCTGCAGCAGCCGGGGTCCCCATACCTGGCTGGCTTTGGCATTGATGTTGCCAAGCCGGAAGAGCTGAAGGACAGTCTCGATGTCGTCCTGGGTCTTCAGGGTGGCCAGGGCGGTGAGCATAATAGGGCTGTAGCCAGCACGGTTCTGTTTGTCCACCTTGCAGACACCTAAGAGACATGGTGTGAACCCTCAGACCAGGGATCGCTGCTAGTGGACTGCCCCAAGGAACGTGGATACCACGTCTCGTCCATCAGTCTAGGCATGCCCTAATCCCTCCCTTTTCTCAGAGGACCCCACTCTGCCCTAGAGGTCTCCATCTCCATTAGACCTGGGGCTCCTAAAGTTGGAGACAGTTCCTCCTCCATCAGATTTGGGGCCCCTGATGCTGGCATCTATATTTAGGGCTGAGAATAGAAACTGGGTCTCCCCTGTTAATTTTGGAACAGCCATTTACCCTCAGACTGGCCCATGTCTCCCCCATCAGATTGTGGGCCCTGAGTCCTTCATCAGCCCGGGAGGCTGTCTCCCCCAGTAGGAGAGGGAAGGGCAAGTTTCTTACTAACTGAGGACCACGTCTTCTTTCCAAGCCCCAGACTTGAGGACGCATCCCTCTCTTAGACCAGGGCTCCAGAGATGTCACCTCCATCATGCAGGCGTGTTAGGTTCACACGTTTCCCTAACATCACTTCTGCCTTTTCCATTATGCTGGCTAAAGGTAGGGCCCGTGCCTCCCCCACCAGACTGGGAAGGAAGTGTCTCCTCCATCAGACTGGGAGGACAGCATCTCCCCCATAAGACCAGGAGGGTAGAGTCTCTGCTATCAGACTAGGAGAGTCATGTCTCCCTCGTTAGACTGGGAAGGTGGTGTCTCACTCATTAGACTAGGAGGGTGGTGTCTCTGCCATTTGACTGGGAAGACAGCGTCTCCTCTATCAGACTGGGAGGGCCACATTCCCCCAACAATGAACCGGGAAGATGATGTCTCCTCCATTAAACTAGGCAGGTGGTGTCTCCTCCATCAGCCTGGGAGGGTGGTGCCCCCCCCATCAGACTGGAAGGGTGGCATCTCCCATATCAAACTGGGAAAGTCACATTTCCCCCATCAGACTGGGGAGGCAGCATCTCCTCCATCAGACTAGGAGGGCCACATCCCCACCACAATGAACTGGGAAGGTGTCTCCTCCATCAGCCTGGGAGGGTGGCATCTCCTCCATCAGACTGGGAGGGCGGCATCTCCTCCATCAGACTGGGAGGGCCATATACCCCACCCCATTGAACTGGGAAGGTGCCGTCTCCTCTATCAAACTGGAAGGCTGGTGTCCCTCCACATCCAATCGGAAGGTGGCATCTGCCACATCAGACTGGGAGAGAGGTGTTCCCTCTATTATACTGAGAAGGCCGCGTCTCCTCCATCATCTTCCCCATCAGATGGGGAGGGCAGTGTCTTCCCTATCAGACTGGGCATGGCGGACAGCTGGCTGGTTTAGAGCCGCCTCGTCCTCCCCGCTGGGCTCACCGCTGTCGAGCAGCTGCTGCACCACGGGGAAGTTGGCATGAAACACGGAGTAGTGCAGGGCTGTGTTGCCGTTGCTGTCGGCGATGTTGACCACGTAGTCCAGCAGCCGCGCAGACATGGCCCGGAACGTGACCAGGTGCCGCCGCACCAGCTCGGGGTGTGCGTCGCTGCGGCAGGCCAGGCGCAGCCACTCCTGCAGCACTGTGGTGTAGGCCACTTTCTGCATGCGAGTCAGGTGGGAGAGGATGTGAGGGCGGGGGAGGCCCACTGGGACACCCCCCACCCCAGATGCGCCCCCGGAGCAAAGCGTGGTGCCCTTGTCCTGGAAAACGATCTCAAGGGAAGTGCAGACCCTCCCAAAGGGAAGTGTAGACATCTCTGTCCCAATAAGACCCTTGGAGTGAGGTGTGGACTTTGCAATCCCCAACACGTTCCCCAAGGAAGGTGTGAGCACCTCCACCCTGGATATAATTTCTCTCTCTCTCTTTTTTTTTTTTTTTTGTGAGACAGAGTCTCGCTCTGTTGCCTAGGCTGGAGTGCAGTTACATGATCAGGACTCACTGCAGCCTCAACCTCCTAGGCTCAAGCTATCCTCCCGCCTCTGCCTCCCAAGTAGCTGGGACCACAGGCGTGCACCACTATGCCTAGCTAATTTTTAAAACAATTTGTAGAGGCTGAGTGCAGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAGGGTGAGCGGATCACTTGAGGTCACGAGTTCGAGACCATCCTGCCCAACATGGTGAAACCCCATCTCTACTCAAAATACAAAAAATTAGCCAGACGTGGTGGCACATGCCTATAGTCCCAGCTACTTGGGAGGTTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTACAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCCTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAATTTTTTTGTAGAAATGGGGTCTCACTATGTTGCCCAGGCTGGTCTTGAACTCCTGGCCTCAAGCGATCCTCCTGCCTTGGCCTCCCAAAGCACCAGGATGACAGGCATGAGCCACTGCGCCCAGCCCTGGTTATAATCGCCAAAGTCAAGTGTAGATGCCCAAAAAGGGAAATCTGGGTGCCCCGCCCCTGAAGCCCCCAGGAAGAACAGGAACCCAAGGCCAGGCTTGGCCAGTGAGTGTTCATCCTCCAGCCTCTCCCCATCTCCCTGGCCTCTCTCCGAGGCCCATGACTTGAGCACCACCACCCCCATGCTCTGGGCTTCAGTGTCAGGGTCCCCACTAGGCAGGAGCAGGAAGTCACTGAGGATGAGGAGAGGCCACGGGTGGGGTGGAGGTAGGGGTCCGGGGGGTGGCCAACCTAGGCCCAGGGCCAGATCGTACCAGCTCCCGCTCTGTGAGGGCGTTGGGATTGTCCAGGTACTTTTCCAGGGCCAAGCAGGCTGAGATGAGGTCAGGGCTTAGCTCCATCCTGCCAGGAACAGACAAAGCGGGGAACTAAGTAAGCCCCGCTGCGGTGCCTGGGAAGGGACTTGACATTCTGCACCACGTCACTCACAATAGGGTCACCTGAATGGTGGCATCTCAGACCCTCCTTCACCCGGGACACACATTTACATTGCACCCCAAGGGGCAGCTGTGGGGAACATGCAGACCCCCAAGGGAGAGTGGACACACAAGCCAAAGTTTATTCCAAATGCCCACTGGCAGATGGAAAATATTTCCCAAGGGCAAATTTTTTCACCAGGGGAATAAAAAAGAGACATAAATAGAACAGACAGGTAGAGGAAACGTCCCAAAGTAGGTGGGTGATTTTGGGATAAACTTTGGCTGGTCCCCTAAATCCTAACCCCGGCAGCCCAAAATAGTTCCACCAGGCCCTTTAGCAAAGCCTCCAGAACTTCAGATGCCCAGAAGGAGCAAGTGCTCGTTTGCTAATTCAGACTAAAGTGTGCATGACTGATAGGAGGGTCCTTCAAAGGGCTTGAACGGTGGGGGTTTGAGGCAGAGGTCATCCACCCCCGGCCCTGCCTGAATCCCTCC
Task1_train_26545
This alteration in KANK2 (KN motif and ankyrin repeat domains 2) on Chromosome 19 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Wooly hair-palmoplantar keratoderma syndrome
TCATAAGCCCCAGTCACCTCCACAGTGCCTGTTTCTGCTTCCCAACACACAGCTGAAGGGAGCGCTCAAACCAGGAATCAGGCCACGCCACTTCCCTGCCTAAATTCCCCTGGCGGTTTCCTGCAGCCCTGAGTCCAAACTGGCTTGAGTCCCGGTGCTCCCTAAAATGCTTATGGCTTGAAGAACGGGCTAGTGAGCTTCAGGAGACCATGCCTGCTTGTTCGCCATTTCAGTCCCCAGTTTTCGGCCCAGGGAACCCAGCTGCTGCTCAATGAACTGTCCAGCAGGATGTGGGATGGGGTCATATTAAGAAAGGTAAGGACCCTCATATCCTCTACTCCTTCTAGTTTCCACAAGAAGGTCCTGTGTCAGAGACAGCCTGGCCATGAAGAGCAGGGCTCTGGAGTTAGACCACCTGGGTTTGGGCCTGTCACTCAGCTGGGATGTCATAAAGTAGGAAGAGCCACCTGGATCTGCAGCAGCCGGGGTCCCCATACCTGGCTGGCTTTGGCATTGATGTTGCCAAGCCGGAAGAGCTGAAGGACAGTCTCGATGTCGTCCTGGGTCTTCAGGGTGGCCAGGGCGGTGAGCATAATAGGGCTGTAGCCAGCACGGTTCTGTTTGTCCACCTTGCAGACACCTAAGAGACATGGTGTGAACCCTCAGACCAGGGATCGCTGCTAGTGGACTGCCCCAAGGAACGTGGATACCACGTCTCGTCCATCAGTCTAGGCATGCCCTAATCCCTCCCTTTTCTCAGAGGACCCCACTCTGCCCTAGAGGTCTCCATCTCCATTAGACCTGGGGCTCCTAAAGTTGGAGACAGTTCCTCCTCCATCAGATTTGGGGCCCCTGATGCTGGCATCTATATTTAGGGCTGAGAATAGAAACTGGGTCTCCCCTGTTAATTTTGGAACAGCCATTTACCCTCAGACTGGCCCATGTCTCCCCCATCAGATTGTGGGCCCTGAGTCCTTCATCAGCCCGGGAGGCTGTCTCCCCCAGTAGGAGAGGGAAGGGCAAGTTTCTTACTAACTGAGGACCACGTCTTCTTTCCAAGCCCCAGACTTGAGGACGCATCCCTCTCTTAGACCAGGGCTCCAGAGATGTCACCTCCATCATGCAGGCGTGTTAGGTTCACACGTTTCCCTAACATCACTTCTGCCTTTTCCATTATGCTGGCTAAAGGTAGGGCCCGTGCCTCCCCCACCAGACTGGGAAGGAAGTGTCTCCTCCATCAGACTGGGAGGACAGCATCTCCCCCATAAGACCAGGAGGGTAGAGTCTCTGCTATCAGACTAGGAGAGTCATGTCTCCCTCGTTAGACTGGGAAGGTGGTGTCTCACTCATTAGACTAGGAGGGTGGTGTCTCTGCCATTTGACTGGGAAGACAGCGTCTCCTCTATCAGACTGGGAGGGCCACATTCCCCCAACAATGAACCGGGAAGATGATGTCTCCTCCATTAAACTAGGCAGGTGGTGTCTCCTCCATCAGCCTGGGAGGGTGGTGCCCCCCCCATCAGACTGGAAGGGTGGCATCTCCCATATCAAACTGGGAAAGTCACATTTCCCCCATCAGACTGGGGAGGCAGCATCTCCTCCATCAGACTAGGAGGGCCACATCCCCACCACAATGAACTGGGAAGGTGTCTCCTCCATCAGCCTGGGAGGGTGGCATCTCCTCCATCAGACTGGGAGGGCGGCATCTCCTCCATCAGACTGGGAGGGCCATATACCCCACCCCATTGAACTGGGAAGGTGCCGTCTCCTCTATCAAACTGGAAGGCTGGTGTCCCTCCACATCCAATCGGAAGGTGGCATCTGCCACATCAGACTGGGAGAGAGGTGTTCCCTCTATTATACTGAGAAGGCCGCGTCTCCTCCATCATCTTCCCCATCAGATGGGGAGGGCAGTGTCTTCCCTATCAGACTGGGCATGGCGGACAGCTGGCTGGTTTAGAGCCGCCTCGTCCTCCCCGCTGGGCTCACCGCTGTCGAGCAGCTGCTGCACCACGGGGAAGTTGGCATGAGACACGGAGTAGTGCAGGGCTGTGTTGCCGTTGCTGTCGGCGATGTTGACCACGTAGTCCAGCAGCCGCGCAGACATGGCCCGGAACGTGACCAGGTGCCGCCGCACCAGCTCGGGGTGTGCGTCGCTGCGGCAGGCCAGGCGCAGCCACTCCTGCAGCACTGTGGTGTAGGCCACTTTCTGCATGCGAGTCAGGTGGGAGAGGATGTGAGGGCGGGGGAGGCCCACTGGGACACCCCCCACCCCAGATGCGCCCCCGGAGCAAAGCGTGGTGCCCTTGTCCTGGAAAACGATCTCAAGGGAAGTGCAGACCCTCCCAAAGGGAAGTGTAGACATCTCTGTCCCAATAAGACCCTTGGAGTGAGGTGTGGACTTTGCAATCCCCAACACGTTCCCCAAGGAAGGTGTGAGCACCTCCACCCTGGATATAATTTCTCTCTCTCTCTTTTTTTTTTTTTTTTGTGAGACAGAGTCTCGCTCTGTTGCCTAGGCTGGAGTGCAGTTACATGATCAGGACTCACTGCAGCCTCAACCTCCTAGGCTCAAGCTATCCTCCCGCCTCTGCCTCCCAAGTAGCTGGGACCACAGGCGTGCACCACTATGCCTAGCTAATTTTTAAAACAATTTGTAGAGGCTGAGTGCAGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAGGGTGAGCGGATCACTTGAGGTCACGAGTTCGAGACCATCCTGCCCAACATGGTGAAACCCCATCTCTACTCAAAATACAAAAAATTAGCCAGACGTGGTGGCACATGCCTATAGTCCCAGCTACTTGGGAGGTTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTACAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCCTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAATTTTTTTGTAGAAATGGGGTCTCACTATGTTGCCCAGGCTGGTCTTGAACTCCTGGCCTCAAGCGATCCTCCTGCCTTGGCCTCCCAAAGCACCAGGATGACAGGCATGAGCCACTGCGCCCAGCCCTGGTTATAATCGCCAAAGTCAAGTGTAGATGCCCAAAAAGGGAAATCTGGGTGCCCCGCCCCTGAAGCCCCCAGGAAGAACAGGAACCCAAGGCCAGGCTTGGCCAGTGAGTGTTCATCCTCCAGCCTCTCCCCATCTCCCTGGCCTCTCTCCGAGGCCCATGACTTGAGCACCACCACCCCCATGCTCTGGGCTTCAGTGTCAGGGTCCCCACTAGGCAGGAGCAGGAAGTCACTGAGGATGAGGAGAGGCCACGGGTGGGGTGGAGGTAGGGGTCCGGGGGGTGGCCAACCTAGGCCCAGGGCCAGATCGTACCAGCTCCCGCTCTGTGAGGGCGTTGGGATTGTCCAGGTACTTTTCCAGGGCCAAGCAGGCTGAGATGAGGTCAGGGCTTAGCTCCATCCTGCCAGGAACAGACAAAGCGGGGAACTAAGTAAGCCCCGCTGCGGTGCCTGGGAAGGGACTTGACATTCTGCACCACGTCACTCACAATAGGGTCACCTGAATGGTGGCATCTCAGACCCTCCTTCACCCGGGACACACATTTACATTGCACCCCAAGGGGCAGCTGTGGGGAACATGCAGACCCCCAAGGGAGAGTGGACACACAAGCCAAAGTTTATTCCAAATGCCCACTGGCAGATGGAAAATATTTCCCAAGGGCAAATTTTTTCACCAGGGGAATAAAAAAGAGACATAAATAGAACAGACAGGTAGAGGAAACGTCCCAAAGTAGGTGGGTGATTTTGGGATAAACTTTGGCTGGTCCCCTAAATCCTAACCCCGGCAGCCCAAAATAGTTCCACCAGGCCCTTTAGCAAAGCCTCCAGAACTTCAGATGCCCAGAAGGAGCAAGTGCTCGTTTGCTAATTCAGACTAAAGTGTGCATGACTGATAGGAGGGTCCTTCAAAGGGCTTGAACGGTGGGGGTTTGAGGCAGAGGTCATCCACCCCCGGCCCTGCCTGAATCCCTCCTACCCAGAAAACTGACCT
TCATAAGCCCCAGTCACCTCCACAGTGCCTGTTTCTGCTTCCCAACACACAGCTGAAGGGAGCGCTCAAACCAGGAATCAGGCCACGCCACTTCCCTGCCTAAATTCCCCTGGCGGTTTCCTGCAGCCCTGAGTCCAAACTGGCTTGAGTCCCGGTGCTCCCTAAAATGCTTATGGCTTGAAGAACGGGCTAGTGAGCTTCAGGAGACCATGCCTGCTTGTTCGCCATTTCAGTCCCCAGTTTTCGGCCCAGGGAACCCAGCTGCTGCTCAATGAACTGTCCAGCAGGATGTGGGATGGGGTCATATTAAGAAAGGTAAGGACCCTCATATCCTCTACTCCTTCTAGTTTCCACAAGAAGGTCCTGTGTCAGAGACAGCCTGGCCATGAAGAGCAGGGCTCTGGAGTTAGACCACCTGGGTTTGGGCCTGTCACTCAGCTGGGATGTCATAAAGTAGGAAGAGCCACCTGGATCTGCAGCAGCCGGGGTCCCCATACCTGGCTGGCTTTGGCATTGATGTTGCCAAGCCGGAAGAGCTGAAGGACAGTCTCGATGTCGTCCTGGGTCTTCAGGGTGGCCAGGGCGGTGAGCATAATAGGGCTGTAGCCAGCACGGTTCTGTTTGTCCACCTTGCAGACACCTAAGAGACATGGTGTGAACCCTCAGACCAGGGATCGCTGCTAGTGGACTGCCCCAAGGAACGTGGATACCACGTCTCGTCCATCAGTCTAGGCATGCCCTAATCCCTCCCTTTTCTCAGAGGACCCCACTCTGCCCTAGAGGTCTCCATCTCCATTAGACCTGGGGCTCCTAAAGTTGGAGACAGTTCCTCCTCCATCAGATTTGGGGCCCCTGATGCTGGCATCTATATTTAGGGCTGAGAATAGAAACTGGGTCTCCCCTGTTAATTTTGGAACAGCCATTTACCCTCAGACTGGCCCATGTCTCCCCCATCAGATTGTGGGCCCTGAGTCCTTCATCAGCCCGGGAGGCTGTCTCCCCCAGTAGGAGAGGGAAGGGCAAGTTTCTTACTAACTGAGGACCACGTCTTCTTTCCAAGCCCCAGACTTGAGGACGCATCCCTCTCTTAGACCAGGGCTCCAGAGATGTCACCTCCATCATGCAGGCGTGTTAGGTTCACACGTTTCCCTAACATCACTTCTGCCTTTTCCATTATGCTGGCTAAAGGTAGGGCCCGTGCCTCCCCCACCAGACTGGGAAGGAAGTGTCTCCTCCATCAGACTGGGAGGACAGCATCTCCCCCATAAGACCAGGAGGGTAGAGTCTCTGCTATCAGACTAGGAGAGTCATGTCTCCCTCGTTAGACTGGGAAGGTGGTGTCTCACTCATTAGACTAGGAGGGTGGTGTCTCTGCCATTTGACTGGGAAGACAGCGTCTCCTCTATCAGACTGGGAGGGCCACATTCCCCCAACAATGAACCGGGAAGATGATGTCTCCTCCATTAAACTAGGCAGGTGGTGTCTCCTCCATCAGCCTGGGAGGGTGGTGCCCCCCCCATCAGACTGGAAGGGTGGCATCTCCCATATCAAACTGGGAAAGTCACATTTCCCCCATCAGACTGGGGAGGCAGCATCTCCTCCATCAGACTAGGAGGGCCACATCCCCACCACAATGAACTGGGAAGGTGTCTCCTCCATCAGCCTGGGAGGGTGGCATCTCCTCCATCAGACTGGGAGGGCGGCATCTCCTCCATCAGACTGGGAGGGCCATATACCCCACCCCATTGAACTGGGAAGGTGCCGTCTCCTCTATCAAACTGGAAGGCTGGTGTCCCTCCACATCCAATCGGAAGGTGGCATCTGCCACATCAGACTGGGAGAGAGGTGTTCCCTCTATTATACTGAGAAGGCCGCGTCTCCTCCATCATCTTCCCCATCAGATGGGGAGGGCAGTGTCTTCCCTATCAGACTGGGCATGGCGGACAGCTGGCTGGTTTAGAGCCGCCTCGTCCTCCCCGCTGGGCTCACCGCTGTCGAGCAGCTGCTGCACCACGGGGAAGTTGGCATGAGACACGGAGTAGTGCAGGACTGTGTTGCCGTTGCTGTCGGCGATGTTGACCACGTAGTCCAGCAGCCGCGCAGACATGGCCCGGAACGTGACCAGGTGCCGCCGCACCAGCTCGGGGTGTGCGTCGCTGCGGCAGGCCAGGCGCAGCCACTCCTGCAGCACTGTGGTGTAGGCCACTTTCTGCATGCGAGTCAGGTGGGAGAGGATGTGAGGGCGGGGGAGGCCCACTGGGACACCCCCCACCCCAGATGCGCCCCCGGAGCAAAGCGTGGTGCCCTTGTCCTGGAAAACGATCTCAAGGGAAGTGCAGACCCTCCCAAAGGGAAGTGTAGACATCTCTGTCCCAATAAGACCCTTGGAGTGAGGTGTGGACTTTGCAATCCCCAACACGTTCCCCAAGGAAGGTGTGAGCACCTCCACCCTGGATATAATTTCTCTCTCTCTCTTTTTTTTTTTTTTTTGTGAGACAGAGTCTCGCTCTGTTGCCTAGGCTGGAGTGCAGTTACATGATCAGGACTCACTGCAGCCTCAACCTCCTAGGCTCAAGCTATCCTCCCGCCTCTGCCTCCCAAGTAGCTGGGACCACAGGCGTGCACCACTATGCCTAGCTAATTTTTAAAACAATTTGTAGAGGCTGAGTGCAGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAGGGTGAGCGGATCACTTGAGGTCACGAGTTCGAGACCATCCTGCCCAACATGGTGAAACCCCATCTCTACTCAAAATACAAAAAATTAGCCAGACGTGGTGGCACATGCCTATAGTCCCAGCTACTTGGGAGGTTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTACAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCCTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAATTTTTTTGTAGAAATGGGGTCTCACTATGTTGCCCAGGCTGGTCTTGAACTCCTGGCCTCAAGCGATCCTCCTGCCTTGGCCTCCCAAAGCACCAGGATGACAGGCATGAGCCACTGCGCCCAGCCCTGGTTATAATCGCCAAAGTCAAGTGTAGATGCCCAAAAAGGGAAATCTGGGTGCCCCGCCCCTGAAGCCCCCAGGAAGAACAGGAACCCAAGGCCAGGCTTGGCCAGTGAGTGTTCATCCTCCAGCCTCTCCCCATCTCCCTGGCCTCTCTCCGAGGCCCATGACTTGAGCACCACCACCCCCATGCTCTGGGCTTCAGTGTCAGGGTCCCCACTAGGCAGGAGCAGGAAGTCACTGAGGATGAGGAGAGGCCACGGGTGGGGTGGAGGTAGGGGTCCGGGGGGTGGCCAACCTAGGCCCAGGGCCAGATCGTACCAGCTCCCGCTCTGTGAGGGCGTTGGGATTGTCCAGGTACTTTTCCAGGGCCAAGCAGGCTGAGATGAGGTCAGGGCTTAGCTCCATCCTGCCAGGAACAGACAAAGCGGGGAACTAAGTAAGCCCCGCTGCGGTGCCTGGGAAGGGACTTGACATTCTGCACCACGTCACTCACAATAGGGTCACCTGAATGGTGGCATCTCAGACCCTCCTTCACCCGGGACACACATTTACATTGCACCCCAAGGGGCAGCTGTGGGGAACATGCAGACCCCCAAGGGAGAGTGGACACACAAGCCAAAGTTTATTCCAAATGCCCACTGGCAGATGGAAAATATTTCCCAAGGGCAAATTTTTTCACCAGGGGAATAAAAAAGAGACATAAATAGAACAGACAGGTAGAGGAAACGTCCCAAAGTAGGTGGGTGATTTTGGGATAAACTTTGGCTGGTCCCCTAAATCCTAACCCCGGCAGCCCAAAATAGTTCCACCAGGCCCTTTAGCAAAGCCTCCAGAACTTCAGATGCCCAGAAGGAGCAAGTGCTCGTTTGCTAATTCAGACTAAAGTGTGCATGACTGATAGGAGGGTCCTTCAAAGGGCTTGAACGGTGGGGGTTTGAGGCAGAGGTCATCCACCCCCGGCCCTGCCTGAATCCCTCCTACCCAGAAAACTGACCT
Task1_train_26546
This sequence change occurs on Chromosome 19, altering KANK2 (KN motif and ankyrin repeat domains 2). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; Nephrotic syndrome 16
CAGGGCTTGGGTGGGGCTCCCCTACCCCCGGCGTCCATGGCTAGGCAGACAGGGACACCGTGATTGGCTCAGCAATGGGCACATGACCCAGGCCAGCCAATGAGGGCCCCCTCTGGGATTTTTACTGGTGCTCTTTGGATTAAGGATCTCCCTCTCCACTAAACTGGACAGACAGATGCCTGGAGCAGTGAGGTCACTTTCCCTTGCCTGCCTGAAAGAGAAGCTCCCAGGGAAAACAAGAAGAGAAAGGCACCAAGTTAGATTCCTGATGATATCTGAGCACTGAGGCCAGCGTGGTGGCTCATGCTTGTAATCCCAGCACTCTGGGAGGCCAAGACAGGAGCATCATTTGAGCCCAGAAGTTTGAGACCAGCCTGGGCAACATAACAAGACTTTGTCTCTACAAAAAATAAAAAAAATTAACGAGGCACAGTGGTGCATGCCTGTAGACCCAGCTACTTGGGAGGCTAAGGCGGGAGGATTGCTTGAGCCTAGGAAGTCAAGGCTGCAGTGAGCCATGATTACACCAACTGCACTCCAGCCTGGGCAATGGAGCGAGACTCTATCTCTTAATAACGACAACAAGAACAAGATATTTGTGCACCTGGATCCAGCCATGCCTGAAGCTGTCATCAGTTACGTAATAACACATTTCCTTTTCACTGCTTGAACAGCTCCGAGATTGATTCCTGCCACTTACTGAATAAACAGGGAGGTTTCTGCCTGGTAAACCAACAGCCTTGGGGAACTTTCCCCCAAATACCTCCCACTTTCTGGATACTGACAAAGTGGCAGTCACCTAATTTCTCTGCATGGTTGCTACAGCCCTGAGGGTTGGCTGCACAATTCTCCTCCTTTTGTGGATGATAAGACAGAGACTCTAAGAGTTGGACTGATGTGTCTGGTGGAAGGTCGGGGGCTGGGGCTGGACCTTGGCATTCTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCCCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTAATCTCAGCTCACTGCAACCTCCGCTTCCCTAGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGGGTAGCTGAGGTTTACAGGCGCACGCCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGTTTCACCATGTTGGCCAGGCTGGTCTCCAACTCCTGACCTCAAGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGCGCCACCGCACCCTGCCTGGACCCTGGCGTTCTGAGAGTCCAGGATGAGCCATGGGAAGAAAGAGGCCCCCCCCCCCCAAGCCATTCTCCCCTGCCTGCCTGCGACCGCTTACCTGCTGCTCCATCGCAGCTTCGCTCTGTGATGCTAATCTTCTTCACCATATGGACGTTGCTGGTAGCTGCAGCGGGCACTGGGCACATTGTCTCCACCACCTCCTGGCTGCGGAACACAGGTGGGCTCTCAGGCCTACCAGGCATTGCCAGGGCCCTCAGCCCTGTGCCGTAAGGCTCCAGGCTCTGGGCCCGCTGTGCGGGGGCGCCAGCGGCTGTGCTGGCCACCACCTCCACCTCCCGTGGCCCTTCTACCACCCGGACTGTATCCACGCGGACCGGGCTGTCCGGCGGTGGCCAGGCCTGGGGCTGGGGGTCAGCCTGCCGGGCCTGAGCTGCCTGCAGCTCCTGCAGCGCCTTCTTGAGCTGGGTCTCCAGCACAGCGACCTTGGCGGCGAGGGCAGCCTCCCCATCAGGCATGCCCAAGTCCCGTTCTCGAACCCAGGTGCCCACACTCCGGGTCTCCAGTGCCACTGGGTCCTCTGGGGGATCGGGGAGGTCCAGGCAGAGCTCGCTGCGACCCCGGCCCGCTGTGGGGTGGCCCAGGAACTTCTGGCTCTTAAGTTGTACTGTGAGCTGCCGCTTTTCCTCCTGGAGCACCGAGAGCTTCACCTGGAGCACAGGGATCAGCTTCACCTGCTCCTCCAGCTGCCGCAGCTTCCGCAGGGCACCCGCCATCTGCTCCCGCACGTGGGCCAGGTGCCCGGCACTGGGAGGCACCGGTGTGGACAGTCCTGAACTCCGTGGTGTCGGGGGTGGCAACCCCACGCCCACCAGGGAGGCTGTCGAGCCGGCCGCACTGGGGGTCAGGGAGCCCAGGCCGGTGGGTGTGGCCGCCTGGTCCTCGAGACGGCGACGGGCATCCAGCAGCGTGCGCTCCACCCGCGGATTGAAGCCACCGCGGGTCTCCAGAGCACCATACTGAGGGTAGAAGCCACGGCCGCAGTAGGAATAGGCTGAGTGGCGGCTGTCCCCACTGGCATTGGAGCACAGCGACTCAGTGGACGTCCACCAGGAGCCAGGGCCACGGGGCAGCGAGCTCAGGCGGGGGCGGCGCTGCACTGCCACGCGTCGCAGCGTGTGGCCCTTCTCGATGTCATCCACGTACTTGAGGAAGTCCAGGTCCAGGCGGTAGCCATAGGGGGTCTCCACGGAGTAGGGTGGATCGGGGTCCTTGGCAGGGAAGGCAGGTGGGGAGGCTGGGCCAGGGGTCCCTGGGGATGGGAGAAACACCAGGACCTTTGAATCCTCTTGTCCCCATTCTCAGGGTGAAGACTGATGCCTGGGGAGAGTTGGGGTTTATTTGCCGAAGAGATGGGAGCCCACCTGGTACTCAACCGCGTCTGCTCTCAGACCCTCCAGAGCAGGGCTATGCCTCCCCTTCAGACTCCCGGCGCTAGGCTATGTCGCCTCTCAAATCCCCCAGGACAGGGCTCTATCCCTCGGCTTAGACTACCCCCTTTTTCCGGTAAGACTCTGCCTCCCCCTTCAGACCCTCCCAGGGCAGGACTCTGCCTCCTCCCTCAGACCTCTAATTGTTGGGCTGTGTCCCACCCTCAAAGTCCCCAGGGCAAGGTCCCCAGCCCCCTCAGGCCTCCAGAACTGAAGCTCCCCGGGGCAGGGCCCTCTTCCCTGAGTCCCCTGACCTGGGAAGGGAGCAGGCACGTGCAGGACCTGGGCCATCTTCTTTTCTACAGATGCTCCTTGGAAGTCACTTGAGGGACTGCGAGTCAGACTGCCTGCAGCACCGGCTGAGGCTTACCTGGGGAAAGAGAACCACGGCGCCGGGAGTTAGGAGTCTGTAGGGGGAGGGGAGGAGATGAGGCCAGCCCCCTCCACAGCTGGTTCACCCAGCCCCCCAACCCAGGTCTGGGACCCACTCATAGACGCACACCCAGCCTGGCTGCGGAAGGGCCCCCCCCGACCCCCTCCCCCCCGCAGGTCTGGAACAAAGAAACCAAACCTCACTGCCTGCTTGCACATCTGTCCAGGCCCTGGACAGGCTCCAGCTGTTCCCATAGCCCAGCCTCCACATAGCCCTGGGGCTGGGGGGCCCCAAGCCCAACAGGCCCCACCCTTCCTGCACCCCCTCCCCTCAGCCCAGGCCCGGAGCTGGCCACACGGAAGGATGGGGGTTGAGGCGCTAAGGGGTTGGGGAAGAAGGGAACCTCGTCTTCCTGCAAGGATCTGAGGAGACAGAGACGCAGGGGGACAAAGAGAGGCAAAGCATGGCGAAGGGGACCCCCAGTGACCCCAAAGCTGAGAGCTGGGTCAGGCCTGGACTGGGTCGGGGGGAAGGGGTAGGGAAAGTTGGGGAGGCAGCTAGGAGTGAAGCCTTTCCCCTTTATGGAAACAATTTTCTCTAAAAATAAACAGTTTCACTGCCGGGCTACACAGAACTTCCTGCCCGCCTAGGATGCGTCCGGGCCCAGGGGCGCAGTAGGGATAGAGGGCCGGGTGGAGGCCCAGGAAGTCCTGGGGGTGGAGGGGAGGAAGTAAGAGGGGGCGCCTGGAGGCTGCAAAAGGGAGGGACAGTCAGAGCCTCTCACTAAACCCCCCTCAGCCTTGGAGGCCGGCCAGGGCTCTTTTGTCCCCAATATAACCCATCTGAACTTGGCTGGTCCTTTCTGTTATCTGACCTCCAGCCATCATGCTGCAGAGGCCCCAGCCCATCCCACCATCAGAGTAAATCCTTTCTGGCCTTTGAGTGCTGGGGCCGGCAGGTACCTTGGGAGGATGGGCCAGGTAGGGCACCTGC
CAGGGCTTGGGTGGGGCTCCCCTACCCCCGGCGTCCATGGCTAGGCAGACAGGGACACCGTGATTGGCTCAGCAATGGGCACATGACCCAGGCCAGCCAATGAGGGCCCCCTCTGGGATTTTTACTGGTGCTCTTTGGATTAAGGATCTCCCTCTCCACTAAACTGGACAGACAGATGCCTGGAGCAGTGAGGTCACTTTCCCTTGCCTGCCTGAAAGAGAAGCTCCCAGGGAAAACAAGAAGAGAAAGGCACCAAGTTAGATTCCTGATGATATCTGAGCACTGAGGCCAGCGTGGTGGCTCATGCTTGTAATCCCAGCACTCTGGGAGGCCAAGACAGGAGCATCATTTGAGCCCAGAAGTTTGAGACCAGCCTGGGCAACATAACAAGACTTTGTCTCTACAAAAAATAAAAAAAATTAACGAGGCACAGTGGTGCATGCCTGTAGACCCAGCTACTTGGGAGGCTAAGGCGGGAGGATTGCTTGAGCCTAGGAAGTCAAGGCTGCAGTGAGCCATGATTACACCAACTGCACTCCAGCCTGGGCAATGGAGCGAGACTCTATCTCTTAATAACGACAACAAGAACAAGATATTTGTGCACCTGGATCCAGCCATGCCTGAAGCTGTCATCAGTTACGTAATAACACATTTCCTTTTCACTGCTTGAACAGCTCCGAGATTGATTCCTGCCACTTACTGAATAAACAGGGAGGTTTCTGCCTGGTAAACCAACAGCCTTGGGGAACTTTCCCCCAAATACCTCCCACTTTCTGGATACTGACAAAGTGGCAGTCACCTAATTTCTCTGCATGGTTGCTACAGCCCTGAGGGTTGGCTGCACAATTCTCCTCCTTTTGTGGATGATAAGACAGAGACTCTAAGAGTTGGACTGATGTGTCTGGTGGAAGGTCGGGGGCTGGGGCTGGACCTTGGCATTCTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCCCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTAATCTCAGCTCACTGCAACCTCCGCTTCCCTAGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGGGTAGCTGAGGTTTACAGGCGCACGCCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGTTTCACCATGTTGGCCAGGCTGGTCTCCAACTCCTGACCTCAAGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGCGCCACCGCACCCTGCCTGGACCCTGGCGTTCTGAGAGTCCAGGATGAGCCATGGGAAGAAAGAGGCCCCCCCCCCCCAAGCCATTCTCCCCTGCCTGCCTGCGACCGCTTACCTGCTGCTCCATCGCAGCTTCGCTCTGTGATGCTAATCTTCTTCACCATATGGACGTTGCTGGTAGCTGCAGCGGGCACTGGGCACATTGTCTCCACCACCTCCTGGCTGCGGAACACAGGTGGGCTCTCAGGCCTACCAGGCATTGCCAGGGCCCTCAGCCCTGTGCCGTAAGGCTCCAGGCTCTGGGCCCGCTGTGCGGGGGCGCCAGCGGCTGTGCTGGCCACCACCTCCACCTCCCGTGGCCCTTCTACCACCCGGACTGTATCCACGCGGACCGGGCTGTCCGGCGGTGGCCAGGCCTGGGGCTGGGGGTCAGCCTGCCGGGCCTGAGCTGCCTGCAGCTCCTGCAGCGCCTTCTTGAGCTGGGTCTCCAGCACAGCGACCTTGGCGGCGAGGGCAGCCTCCCCATCAGGCATGCCCAAGTCCCGTTCTCGAACCCAGGTGCCCACACTCCGGGTCTCCAGTGCCACTGGGTCCTCTGGGGGATCGGGGAGGTCCAGGCAGAGCTCGCTGCGACCCCGGCCCGCTGTGGGGTGGCCCAGGAACTTCTGGCTCTTAAGTTGTACTGTGAGCTGCCGCTTTTCCTCCTGGAGCACCGAGAGCTTCACCTGGAGCACAGGGATCAGCTTCACCTGCTCCTCCAGCTGCCGCAGCTTCCGCAGGGCACCCGCCATCTGCTCCCGCACGTGGGCCAGGTGCCCGGCACCGGGAGGCACCGGTGTGGACAGTCCTGAACTCCGTGGTGTCGGGGGTGGCAACCCCACGCCCACCAGGGAGGCTGTCGAGCCGGCCGCACTGGGGGTCAGGGAGCCCAGGCCGGTGGGTGTGGCCGCCTGGTCCTCGAGACGGCGACGGGCATCCAGCAGCGTGCGCTCCACCCGCGGATTGAAGCCACCGCGGGTCTCCAGAGCACCATACTGAGGGTAGAAGCCACGGCCGCAGTAGGAATAGGCTGAGTGGCGGCTGTCCCCACTGGCATTGGAGCACAGCGACTCAGTGGACGTCCACCAGGAGCCAGGGCCACGGGGCAGCGAGCTCAGGCGGGGGCGGCGCTGCACTGCCACGCGTCGCAGCGTGTGGCCCTTCTCGATGTCATCCACGTACTTGAGGAAGTCCAGGTCCAGGCGGTAGCCATAGGGGGTCTCCACGGAGTAGGGTGGATCGGGGTCCTTGGCAGGGAAGGCAGGTGGGGAGGCTGGGCCAGGGGTCCCTGGGGATGGGAGAAACACCAGGACCTTTGAATCCTCTTGTCCCCATTCTCAGGGTGAAGACTGATGCCTGGGGAGAGTTGGGGTTTATTTGCCGAAGAGATGGGAGCCCACCTGGTACTCAACCGCGTCTGCTCTCAGACCCTCCAGAGCAGGGCTATGCCTCCCCTTCAGACTCCCGGCGCTAGGCTATGTCGCCTCTCAAATCCCCCAGGACAGGGCTCTATCCCTCGGCTTAGACTACCCCCTTTTTCCGGTAAGACTCTGCCTCCCCCTTCAGACCCTCCCAGGGCAGGACTCTGCCTCCTCCCTCAGACCTCTAATTGTTGGGCTGTGTCCCACCCTCAAAGTCCCCAGGGCAAGGTCCCCAGCCCCCTCAGGCCTCCAGAACTGAAGCTCCCCGGGGCAGGGCCCTCTTCCCTGAGTCCCCTGACCTGGGAAGGGAGCAGGCACGTGCAGGACCTGGGCCATCTTCTTTTCTACAGATGCTCCTTGGAAGTCACTTGAGGGACTGCGAGTCAGACTGCCTGCAGCACCGGCTGAGGCTTACCTGGGGAAAGAGAACCACGGCGCCGGGAGTTAGGAGTCTGTAGGGGGAGGGGAGGAGATGAGGCCAGCCCCCTCCACAGCTGGTTCACCCAGCCCCCCAACCCAGGTCTGGGACCCACTCATAGACGCACACCCAGCCTGGCTGCGGAAGGGCCCCCCCCGACCCCCTCCCCCCCGCAGGTCTGGAACAAAGAAACCAAACCTCACTGCCTGCTTGCACATCTGTCCAGGCCCTGGACAGGCTCCAGCTGTTCCCATAGCCCAGCCTCCACATAGCCCTGGGGCTGGGGGGCCCCAAGCCCAACAGGCCCCACCCTTCCTGCACCCCCTCCCCTCAGCCCAGGCCCGGAGCTGGCCACACGGAAGGATGGGGGTTGAGGCGCTAAGGGGTTGGGGAAGAAGGGAACCTCGTCTTCCTGCAAGGATCTGAGGAGACAGAGACGCAGGGGGACAAAGAGAGGCAAAGCATGGCGAAGGGGACCCCCAGTGACCCCAAAGCTGAGAGCTGGGTCAGGCCTGGACTGGGTCGGGGGGAAGGGGTAGGGAAAGTTGGGGAGGCAGCTAGGAGTGAAGCCTTTCCCCTTTATGGAAACAATTTTCTCTAAAAATAAACAGTTTCACTGCCGGGCTACACAGAACTTCCTGCCCGCCTAGGATGCGTCCGGGCCCAGGGGCGCAGTAGGGATAGAGGGCCGGGTGGAGGCCCAGGAAGTCCTGGGGGTGGAGGGGAGGAAGTAAGAGGGGGCGCCTGGAGGCTGCAAAAGGGAGGGACAGTCAGAGCCTCTCACTAAACCCCCCTCAGCCTTGGAGGCCGGCCAGGGCTCTTTTGTCCCCAATATAACCCATCTGAACTTGGCTGGTCCTTTCTGTTATCTGACCTCCAGCCATCATGCTGCAGAGGCCCCAGCCCATCCCACCATCAGAGTAAATCCTTTCTGGCCTTTGAGTGCTGGGGCCGGCAGGTACCTTGGGAGGATGGGCCAGGTAGGGCACCTGC
Task1_train_26547
A genetic alteration is present in DOCK6 (dedicator of cytokinesis 6) on Chromosome 19. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; DOCK6-related disorder
AAAAAATCACATGGATATTTTACACTGGAAAAAAATATATAATATCTGAATTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACTGCAAGCTCCGCCTCCCGTGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCACCACCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTCAGCCTCCTGCAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCTAATATCTGAAATTAAGAACTCAACGGATGGGGTCAACAGGACACTGGGCACAACAGAAGACATAAGTGGTGAACTCATAGACAAGTGAACAAAAAACTTCCCAGTTGGATTACAGAGAGGAAAGAATGGAAAAAACAGAACAGGACATAACAGATGTGATCAAAAGGCCTAATATATGTGTAATTGGAGTCCCAGGAGTGAAGAGTGAAAATGAGGCAGAAAAAAATTCAAGTGAGAATGGCTAAGAATTTCCCCAAACTGATGAAAGGCATCCACCCACAAATCCCAATTTTGTACTTCCAACCACTGTTATACCACCCCCCTCAACAATGCCTATAAATGTTTGTTGAAAATGAGTGAATGAATGTACTCCAATCATTTTCTCACTTGGATGTTCCCTACTTTTTGCTCTTCTTAGAAAATAATAAATGGTACAATAATATCTCCCATCTATTGTAGGCTGACAATATCTCAGTACTACAGCCCCCCACATTTTCACATAACCTTATGAAGTAGTTGGTGTTGTTACTGTCTCCATTACAGGGGAGAAACCTGAGGCTCAGAGATGTTATGACTTAAGTAGTCTGTCCTAGCACTTTAACCTGCTCTGCTAATCCTAATGTCTATACTCATACCAGTGACTGTGTTCTCCCACCTTTACTATCCTGTGCCTTCTGTGACCAAGTCCCTGGATCATGTGACCCCATCTTCCCCTGGCCCACTGACCAGCAAAGTCATGCAGCCGTGGCAAGGTATCCCGTGCAATCGATAGCAGTGGCAGGTACAGCTCGGCCACACGAGCCTTCACAGTGGCCTCGGCGTAGCGGGGGTCAGTGTCATGGCCACATAGCAGGCTGTGCACAGCACTGATGGCCTTCTTGTGCAACAGGAATGCCCTATGGGGTAATGAGGTGCTCAGGACAGGGTGGACATGGCTCCTGGACTGTCCCACCTGTCCTGGGGCTAGACAGGAGCTCTGCTCACCCTTCAGCCTCAGGTTCGAGGGCCAGTGCCAGCTCCGTCAGCAGGAGCCCAGCTAGGAAGTGCTGCTGCCGGAATGGTCCACTCAGTTCGAACATGCTGGTCACCTTGGGGTCCGGGGCTTGGCTGGAGAAGGTGGAGCTCTGCAGAGTGGGGGAAAAATGGGGGATGCCAGCGGTCAAGGGTCAGAGGTGGCAGGTCACCATTAAAGCCATCTTGGAGGTGACAGAAATCATGGTGCCAATAGCCACAGATGAAAGACTGATGTTAAGTCATCTGGAGGTGACAGTGGGCATGGGTTTCAAGGCCAGAAGTGAGGGGCTGACGTTAACCCATCTGTGATGTAACAGGGCACGGAGTCAAAAGTCAGAGGACTGAGAAATAGCAGATGGAACACTGGGCTGGGAGTTAGGATTTAGGGGAGAGAAATCAGAGGTTAGTCCTTCTGGGAAATTGCTGAGAATGGCAAGAGAGGTGAAGGGTCAGAAGTCAAAAGTCAAACATAAGGGATTAGTTCACCTAGGCAGTGGTCCACCGTGAAAGGGACAGAGATGAGGGAACCATAGGAGATGGACTGAAGGTGAGAGGTTGTAGGTCAAAGAGAGGAGGCAGAAGTGAAGGCAGCCCACCTGGGAGGTGGTGGAGGACACAGAGGGGGAGGGCGAGGCTGGAGGTGACAGGGGGCAGCAGGGGAGGTTGAGGGTCACGTAGTGCTCGTGGCTGCACAGGATGCGGGTGAATTCCATGCGCAGGGTCAGCAGGGCTGCTGGATTAGGGGACGACTGGAGCCGCGTGGCCACCTGCAGGAGAGGGGTGGCCATCAGTGATGTCAACATTGCTCCGCCTTCCATCCATGCCATGCCCACCCTGCCCACGCCCACTCCTACCTGCTTGTAGTGGGCCCGGACCAGGCTGAAGACAAAGCCCCGGTCCACCAGGGACAGAAGGTCACTGAGGAAGAAAGCCAGGCTGGCGTTGAGGTGCTCGGCCAGCTCCACATCCTGGGGACACAGGTGCCTGTCAACCCACACACCCAAACCTCAGCCCCGACAGGGGCTTGGCTCTCACCAAGATCATCTGCCACCCCTAGGAGCTGTATCACTGCCCCAAAGCCTTTGTCTGTGGGCTGTGGTGACTCTGGGACTTCCTGGTTGTCCTCCTCAGGCTGCCTTCCCCTCCCATGCTCCTTAAGACACCAAGGCAGATATGGGCTAACTCCCTGCAAGATCCTCTCGCTCTCTCTGTCCAGAGTTCAGAGCTGGGGAGAGACTATATTTCCCAGCCTCCCTTCCAGTTGAACCACATGACCAATTCTGGCCAATGGGATTTGAGGGGAAAGTGAGGTGGCCACTTATATGGCAGAAGCAGGTGGGTGCCGGGGAACTGCCAGGGCCAGGCCCACACAGTGATGCCTCTACAACCTACTTAATACTCAGAAATAAGCTATGGTTATTTAAATCACTTGTGACTGTGTTGAAGCGAATTAGCCTCTGCCCTAACTGATCGACTCTTACCATCATTTATTTTTATTTTAATTTTAATTAATTAATTTATTTTTTGAGATGGAGTCTTGCTCTGTCACTAAGGCTGGAGTACAGTGGCACAATCTCGGCTCACTGCAACTTCTGTCTCCCAGGTTCAAGCGATTCTTCTGCCTCAGCTTCCCCAGTAGCTTGGATTACAGACACCCACCACCACGCCTAGCTAATTTTTTTATTTTTAGTAGAGATGGGGTTTTGCCATATTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTGCTTCCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCGTGAGATACCGCACCCGGCCTCTCAGCACCATTTAATGTGAGCTTTACTGAGCATCTACTCTGTGCCAATCCCTGTGAATGAGGCAGATGCCATCCCTGCTGCGGGTCCAACTCAATCCAGTGTGTGTGTGTGGGGCGGGGGCAGGGAGACACAAAATAAACAAGAATTTCAGATAGTTCTATGTGCTTCAAAGACAATATTAAATTGGTGCAAAAGTAATTGCAGTTTTGCAATTACTTTCAATGGCAAAAACTGTAATTACTTTTCTTTCTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTATAGTGCAATGGCGCGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGTGCGCACCACCACACCTGGCTAACTTCTGTGTTTTTAGTAGAGACAGGGTTTCACCATGTTGGTAAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCTCCTCGGCCTCCTAAAGTGTTGGGATTACAGGCGTGAGCCACCATGCCCAGCCTATAATTACTTGTCACCAACCTTAACAGACGGGGGTGACATTTTCAGAGATACTGAAGGATACCAAAGAGCCATGGGGAGAATGGCATCCTGGGTTAAGGGAACAGTCAGTGCAAAGGCCCTGAGGCAGGATGTGCCTAGCAAGTCCGGGGAACAGTGAGGTGGCTGATGTGGCCCTGAGGCCCAGCTGGTATTCGTTCTGCCCTCATACTCTCTTGAGCCACTCTGAGGCCTCACAAGTTAGCCTCAGTGGCCCTCAAATCCCTGCAACCCGGCCAGGCATGGTGGCTCCTGCCTGTAATCCTAGCACTTTAGGAGGCTGAGGTGGGTGGATCACAGGGTCAGGAGTTTGAGATCAG
AAAAAATCACATGGATATTTTACACTGGAAAAAAATATATAATATCTGAATTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACTGCAAGCTCCGCCTCCCGTGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCACCACCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTCAGCCTCCTGCAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCTAATATCTGAAATTAAGAACTCAACGGATGGGGTCAACAGGACACTGGGCACAACAGAAGACATAAGTGGTGAACTCATAGACAAGTGAACAAAAAACTTCCCAGTTGGATTACAGAGAGGAAAGAATGGAAAAAACAGAACAGGACATAACAGATGTGATCAAAAGGCCTAATATATGTGTAATTGGAGTCCCAGGAGTGAAGAGTGAAAATGAGGCAGAAAAAAATTCAAGTGAGAATGGCTAAGAATTTCCCCAAACTGATGAAAGGCATCCACCCACAAATCCCAATTTTGTACTTCCAACCACTGTTATACCACCCCCCTCAACAATGCCTATAAATGTTTGTTGAAAATGAGTGAATGAATGTACTCCAATCATTTTCTCACTTGGATGTTCCCTACTTTTTGCTCTTCTTAGAAAATAATAAATGGTACAATAATATCTCCCATCTATTGTAGGCTGACAATATCTCAGTACTACAGCCCCCCACATTTTCACATAACCTTATGAAGTAGTTGGTGTTGTTACTGTCTCCATTACAGGGGAGAAACCTGAGGCTCAGAGATGTTATGACTTAAGTAGTCTGTCCTAGCACTTTAACCTGCTCTGCTAATCCTAATGTCTATACTCATACCAGTGACTGTGTTCTCCCACCTTTACTATCCTGTGCCTTCTGTGACCAAGTCCCTGGATCATGTGACCCCATCTTCCCCTGGCCCACTGACCAGCAAAGTCATGCAGCCGTGGCAAGGTATCCCGTGCAATCGATAGCAGTGGCAGGTACAGCTCGGCCACACGAGCCTTCACAGTGGCCTCGGCGTAGCGGGGGTCAGTGTCATGGCCACATAGCAGGCTGTGCACAGCACTGATGGCCTTCTTGTGCAACAGGAATGCCCTATGGGGTAATGAGGTGCTCAGGACAGGGTGGACATGGCTCCTGGACTGTCCCACCTGTCCTGGGGCTAGACAGGAGCTCTGCTCACCCTTCAGCCTCAGGTTCGAGGGCCAGTGCCAGCTCCGTCAGCAGGAGCCCAGCTAGGAAGTGCTGCTGCCGGAATGGTCCACTCAGTTCGAACATGCTGGTCACCTTGGGGTCCGGGGCTTGGCTGGAGAAGGTGGAGCTCTGCAGAGTGGGGGAAAAATGGGGGATGCCAGCGGTCAAGGGTCAGAGGTGGCAGGTCACCATTAAAGCCATCTTGGAGGTGACAGAAATCATGGTGCCAATAGCCACAGATGAAAGACTGATGTTAAGTCATCTGGAGGTGACAGTGGGCATGGGTTTCAAGGCCAGAAGTGAGGGGCTGACGTTAACCCATCTGTGATGTAACAGGGCACGGAGTCAAAAGTCAGAGGACTGAGAAATAGCAGATGGAACACTGGGCTGGGAGTTAGGATTTAGGGGAGAGAAATCAGAGGTTAGTCCTTCTGGGAAATTGCTGAGAATGGCAAGAGAGGTGAAGGGTCAGAAGTCAAAAGTCAAACATAAGGGATTAGTTCACCTAGGCAGTGGTCCACCGTGAAAGGGACAGAGATGAGGGAACCATAGGAGATGGACTGAAGGTGAGAGGTTGTAGGTCAAAGAGAGGAGGCAGAAGTGAAGGCAGCCCACCTGGGAGGTGGTGGAGGACACAGAGGGGGAGGGCGAGGCTGGAGGTGACAGGGGGCAGCAGGGGAGGTTGAGGGTCACGTAGTGCTTGTGGCTGCACAGGATGCGGGTGAATTCCATGCGCAGGGTCAGCAGGGCTGCTGGATTAGGGGACGACTGGAGCCGCGTGGCCACCTGCAGGAGAGGGGTGGCCATCAGTGATGTCAACATTGCTCCGCCTTCCATCCATGCCATGCCCACCCTGCCCACGCCCACTCCTACCTGCTTGTAGTGGGCCCGGACCAGGCTGAAGACAAAGCCCCGGTCCACCAGGGACAGAAGGTCACTGAGGAAGAAAGCCAGGCTGGCGTTGAGGTGCTCGGCCAGCTCCACATCCTGGGGACACAGGTGCCTGTCAACCCACACACCCAAACCTCAGCCCCGACAGGGGCTTGGCTCTCACCAAGATCATCTGCCACCCCTAGGAGCTGTATCACTGCCCCAAAGCCTTTGTCTGTGGGCTGTGGTGACTCTGGGACTTCCTGGTTGTCCTCCTCAGGCTGCCTTCCCCTCCCATGCTCCTTAAGACACCAAGGCAGATATGGGCTAACTCCCTGCAAGATCCTCTCGCTCTCTCTGTCCAGAGTTCAGAGCTGGGGAGAGACTATATTTCCCAGCCTCCCTTCCAGTTGAACCACATGACCAATTCTGGCCAATGGGATTTGAGGGGAAAGTGAGGTGGCCACTTATATGGCAGAAGCAGGTGGGTGCCGGGGAACTGCCAGGGCCAGGCCCACACAGTGATGCCTCTACAACCTACTTAATACTCAGAAATAAGCTATGGTTATTTAAATCACTTGTGACTGTGTTGAAGCGAATTAGCCTCTGCCCTAACTGATCGACTCTTACCATCATTTATTTTTATTTTAATTTTAATTAATTAATTTATTTTTTGAGATGGAGTCTTGCTCTGTCACTAAGGCTGGAGTACAGTGGCACAATCTCGGCTCACTGCAACTTCTGTCTCCCAGGTTCAAGCGATTCTTCTGCCTCAGCTTCCCCAGTAGCTTGGATTACAGACACCCACCACCACGCCTAGCTAATTTTTTTATTTTTAGTAGAGATGGGGTTTTGCCATATTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTGCTTCCCTTGGCTTCCCAAAGTGCTGGGATTACAGGCGTGAGATACCGCACCCGGCCTCTCAGCACCATTTAATGTGAGCTTTACTGAGCATCTACTCTGTGCCAATCCCTGTGAATGAGGCAGATGCCATCCCTGCTGCGGGTCCAACTCAATCCAGTGTGTGTGTGTGGGGCGGGGGCAGGGAGACACAAAATAAACAAGAATTTCAGATAGTTCTATGTGCTTCAAAGACAATATTAAATTGGTGCAAAAGTAATTGCAGTTTTGCAATTACTTTCAATGGCAAAAACTGTAATTACTTTTCTTTCTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTATAGTGCAATGGCGCGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGTGCGCACCACCACACCTGGCTAACTTCTGTGTTTTTAGTAGAGACAGGGTTTCACCATGTTGGTAAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCTCCTCGGCCTCCTAAAGTGTTGGGATTACAGGCGTGAGCCACCATGCCCAGCCTATAATTACTTGTCACCAACCTTAACAGACGGGGGTGACATTTTCAGAGATACTGAAGGATACCAAAGAGCCATGGGGAGAATGGCATCCTGGGTTAAGGGAACAGTCAGTGCAAAGGCCCTGAGGCAGGATGTGCCTAGCAAGTCCGGGGAACAGTGAGGTGGCTGATGTGGCCCTGAGGCCCAGCTGGTATTCGTTCTGCCCTCATACTCTCTTGAGCCACTCTGAGGCCTCACAAGTTAGCCTCAGTGGCCCTCAAATCCCTGCAACCCGGCCAGGCATGGTGGCTCCTGCCTGTAATCCTAGCACTTTAGGAGGCTGAGGTGGGTGGATCACAGGGTCAGGAGTTTGAGATCAG
Task1_train_26548
The gene DOCK6 (dedicator of cytokinesis 6) is located on Chromosome 19, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Adams-Oliver syndrome 2
AAAAGGGGAAACTGAGGCACTGAAGTTTTTTGTTGGTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGGAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTTAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACGTGCCACCATGCCCAGCTAATTTTTTGTGTTTTTAGTAGAGACAGGGTTTCTATGTATGTATTTATTTATTATATAGAGACGGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCAAACTCTTGGGCTCAAGTGATGCCCCCGCCTCTGCCTCCCAAAGTGCTGGGATAATAGGCATGAGCCATCACGTCCCCGGCTTGCTGTGAATTTTTTATTTTATTTTTTTAGACAGAGTCTCCCCTGTTGCCCAGGCTGAAGTGCGTGGTGGGATTTCACCATGTTGGCCAGGCTGGTCCCACCCGCCTCAGCCTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCGCCCCGCCGACACTGAAGTTTTTTTCCCCCTCCCTACACCCTCAGTAAGTAACTCACACAGAGCTCCTCCTCCCTGCAACCACGGCCCTTGTTCCGTTGGCATGGGGGCAGTTTTGGGCTCAACAATCCCCACATCTTGAAATTCTCAACTTCCGGGTTTCCCCATCCCTCCTTTCTGGGGTGTCATCTGCCGCCATTGTCACTCTGCACGGAGTTCCCATCTCGCTCACCTGAACGGCCACCATAAAAGTCCTTCCCTGTCTTACTCCACCTTGCTGGCCTCCGCTCACCACGCACCTCCAAACTGAAACACTGAGCACTCCCCGTTACACCCCTTCCATCCTCTCTATTCAGCCAGCTCCTCTTCCTCACTGGGTCTCCATGTACACGTCCCCCTGCAAGGGAAGCTGTCCCAGATACCCGCTCGCACCCCTCAAGCTGGGCCAGGGGACTCCTCCAGGACTCTAGGCACTTTCAGCATCGCTTATCCCGGCTCTGTGTGGTCATCGCATGGTTATGTGTCCTGTATACAGTAGGGACTTCATAAATGTTTTATTTTTGTTTCTTTGTTTGTTTGAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGAAACCTCTGCCCTCCGGGTCAAGAGATTCTCCCGCCTCAGCCTCCCAAGTAGTGGGGATTACAGGTGCCTGCCACCACGTCTGGCTAATTTTTTTTTTTTTTTTTCAGTAGAGATGGTGTTTTGCCATGTTGGCCAGGCTGGTCTCAAATTCCTGAGCTCAGGTGATCCGCCCGCCTTGGCTTCCCAGAGTATTAGGATTACAGGTGGGAGCCACCGTGCCCGGCCAATAAGTGTTTGTTGAATGACTGGATGAGCCCACAGAGCCAGGTCCCAATCCTTGTGTTTAGGGCAGGAGGCCCACCCAGGCCTCAGGCCAGAATGGAGCCTCCCTTTCCTGCCCCGATCCAGGCAAGAACTCGGGGTGGGGAGCGGCAGGGCCAGGCTCAGGTCCAAGTCCACATCCTGTTCAACTCTGTTCCCACGCACTTCTGCTGCTCCCCGGGGGCTGGTGTGGAGGGGCCCTGGGCGGCTGAGAGCCAGGCCCAGGGTCACTAGCACCCGCCCCAAAGCCTCCCGGCCAAACCCTGGATCCCAGCAGCAGAGCAGGCAAGCGCCAGACTCCAGCCTTACAAGTTGTATGGTCTTGGCGTCATGTCACCACTCTGTGCCTCAGTTTCCCCACCTGTGCCCACTTCATGAGGTTGTGGTGAATATAAGACGGGTTCATATACATGAAAGGCTGAGAACTGATCCTGGCATACAATTGGCACTTAAGGATTGGAGACTCGGGATAATGAAAAAGGAAGTCTTCCTTCCCCCATAAAAGCCCATACATAGGTGGCCACATAGGTGACAGGGCCGCACACGGTAATGGCACTACTCATGTAGTGTGTACCCCGCCGGAACCCATGTGGTTGCTTCACGCATCTAAGAAGAGAGACATGTCAGTATACTCACTTGAGCGACAGACACTTGACCAAGATCCTTTGTCCAAAGTGCTCGCGGGGTGGCTCTGGGCGGCTACAGCGTTCCACGGCTTCATCCTGCCAAGAGTGGGGGGTGGGAGCTGGGCGGGAGGAGCTGGGACATCCTCCAGGAAGGGTCTGGAATGCCCAGCCTCAGACCAGCTCTACCCCAGCCTGACTAACCGTCTTTCCATCCCTGCCTCTGAGCCTTTACACGTGCTGTTCCCCTGCCTGGAATGCCCATCTTCTCCCACTCCTCCTTGTCTCGCTAATGTCTGCTCACTGTTCATATATACTTCTACTATATAGAGGTATATAGTAGGTGTCCATATATAGAAGCTTATTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCATGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTGCAGCTTAGCCAACACTTCCTCCAGGAAGTCCTCCCTGACCCCTGAGGCCTGGGCAGGCACCTCTTTCGGGTGCCCACAATGTCCTGGTGTAAGGAGCCATGGTGGCTGGGACACTGAGGACCGTGTGAGGGACAATTACCAGCACCTCATCATGGCACTACTCTGTCTGGGTTATACGTTCCTAGTAGAGAGGTCTCTCCTCCGCTAGTGAACTCTGAAGGCAGGGACTGGGTCTCTCTATTCATGGCTATATCCCCAATGCCAACAATACAGTGGGTACCCAAACATGTTAGTCGAATAATTATAGAGGTATACAATAGGTACCTACTAAAAGTTAGTTGGATGAACATAAGCATATACAGAAAGCATTCAATAAATGTTGACTGGAGATATAGGGATATACACCCAATAACGCACCCAGTAAGTACTGATTGAATAAATATGGGTGTATATAGTAAGCACTCAATAAATGGCCAAATACAACCACAGGAGTATATACTAGGTACCAAATAAATGTTGGTTGGATAAAAATAGACATATGTGGTAGGTGTTCAATAGATATTGGTTGATTAAATAGAGAACTATACAGTAGGCATTCATGTATTGAATAAATATAGGGATATACAGTTGGTACCCAATACATGCTTGTTGGATAAATAATTTTTAAAAATTTATTTTCTGGCCAGGCGCAGTGGCTCATGCCTGTAATACCAGCACTCTGGGAGGCTGAGGCGGGCAGATCACAAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATAGTGAAACCCTATCTCTACTAAAAATACAAAAATTAGCCAGGCATAGTGGCACGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATGGCGCCACTGCACTCCAGCCTGGGTGACAGAACGAGACTTGTCTCAAAAAAAAAAATTTATTTTATATATTTTTTTACCTTTCCTATGGTGTTGATGGTTGGATAAATATAGGAGTATATAGTAGGTGTCCATATATAAAAGCTATTGAGGCCAGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCCAAACCCCGTCTCTACTAAAAAAAATACAAAATTAGCCGGGCGTGGTGGCTGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATAGCGCCACTGCAGTCCAGCCTGGGCGACAAGAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAGCTATTGAATAAACACAGGGGATAGAGTAGGTGCCCAATAAATACTGGTTAGCTAACTATAAAGGTATATAGTAGGTGTCCATATACAGAAGCTATCTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAATGCAGTGGTGCGATCTTGGCTCACTGCAACCTCTGCCTCCTAGGTTCAAGTGATTCTCCTGTCTCAGCC
AAAAGGGGAAACTGAGGCACTGAAGTTTTTTGTTGGTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGGAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTTAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACGTGCCACCATGCCCAGCTAATTTTTTGTGTTTTTAGTAGAGACAGGGTTTCTATGTATGTATTTATTTATTATATAGAGACGGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCAAACTCTTGGGCTCAAGTGATGCCCCCGCCTCTGCCTCCCAAAGTGCTGGGATAATAGGCATGAGCCATCACGTCCCCGGCTTGCTGTGAATTTTTTATTTTATTTTTTTAGACAGAGTCTCCCCTGTTGCCCAGGCTGAAGTGCGTGGTGGGATTTCACCATGTTGGCCAGGCTGGTCCCACCCGCCTCAGCCTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCGCCCCGCCGACACTGAAGTTTTTTTCCCCCTCCCTACACCCTCAGTAAGTAACTCACACAGAGCTCCTCCTCCCTGCAACCACGGCCCTTGTTCCGTTGGCATGGGGGCAGTTTTGGGCTCAACAATCCCCACATCTTGAAATTCTCAACTTCCGGGTTTCCCCATCCCTCCTTTCTGGGGTGTCATCTGCCGCCATTGTCACTCTGCACGGAGTTCCCATCTCGCTCACCTGAACGGCCACCATAAAAGTCCTTCCCTGTCTTACTCCACCTTGCTGGCCTCCGCTCACCACGCACCTCCAAACTGAAACACTGAGCACTCCCCGTTACACCCCTTCCATCCTCTCTATTCAGCCAGCTCCTCTTCCTCACTGGGTCTCCATGTACACGTCCCCCTGCAAGGGAAGCTGTCCCAGATACCCGCTCGCACCCCTCAAGCTGGGCCAGGGGACTCCTCCAGGACTCTAGGCACTTTCAGCATCGCTTATCCCGGCTCTGTGTGGTCATCGCATGGTTATGTGTCCTGTATACAGTAGGGACTTCATAAATGTTTTATTTTTGTTTCTTTGTTTGTTTGAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGAAACCTCTGCCCTCCGGGTCAAGAGATTCTCCCGCCTCAGCCTCCCAAGTAGTGGGGATTACAGGTGCCTGCCACCACGTCTGGCTAATTTTTTTTTTTTTTTTTCAGTAGAGATGGTGTTTTGCCATGTTGGCCAGGCTGGTCTCAAATTCCTGAGCTCAGGTGATCCGCCCGCCTTGGCTTCCCAGAGTATTAGGATTACAGGTGGGAGCCACCGTGCCCGGCCAATAAGTGTTTGTTGAATGACTGGATGAGCCCACAGAGCCAGGTCCCAATCCTTGTGTTTAGGGCAGGAGGCCCACCCAGGCCTCAGGCCAGAATGGAGCCTCCCTTTCCTGCCCCGATCCAGGCAAGAACTCGGGGTGGGGAGCGGCAGGGCCAGGCTCAGGTCCAAGTCCACATCCTGTTCAACTCTGTTCCCACGCACTTCTGCTGCTCCCCGGGGGCTGGTGTGGAGGGGCCCTGGGCGGCTGAGAGCCAGGCCCAGGGTCACTAGCACCCGCCCCAAAGCCTCCCGGCCAAACCCTGGATCCCAGCAGCAGAGCAGGCAAGCGCCAGACTCCAGCCTTACAAGTTGTATGGTCTTGGCGTCATGTCACCACTCTGTGCCTCAGTTTCCCCACCTGTGCCCACTTCATGAGGTTGTGGTGAATATAAGACGGGTTCATATACATGAAAGGCTGAGAACTGATCCTGGCATACAATTGGCACTTAAGGATTGGAGACTCGGGATAATGAAAAAGGAAGTCTTCCTTCCCCCATAAAAGCCCATACATAGGTGGCCACATAGGTGACAGGGCCGCACACGGTAATGGCACTACTCATGTAGTGTGTACCCCGCCGGAACCCATGTGGTTGCTTCACGCATCTAAGAAGAGAGACATGTCAGTATACTCACTTGAGCGACAGACACTTGTCCAAGATCCTTTGTCCAAAGTGCTCGCGGGGTGGCTCTGGGCGGCTACAGCGTTCCACGGCTTCATCCTGCCAAGAGTGGGGGGTGGGAGCTGGGCGGGAGGAGCTGGGACATCCTCCAGGAAGGGTCTGGAATGCCCAGCCTCAGACCAGCTCTACCCCAGCCTGACTAACCGTCTTTCCATCCCTGCCTCTGAGCCTTTACACGTGCTGTTCCCCTGCCTGGAATGCCCATCTTCTCCCACTCCTCCTTGTCTCGCTAATGTCTGCTCACTGTTCATATATACTTCTACTATATAGAGGTATATAGTAGGTGTCCATATATAGAAGCTTATTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCATGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTGCAGCTTAGCCAACACTTCCTCCAGGAAGTCCTCCCTGACCCCTGAGGCCTGGGCAGGCACCTCTTTCGGGTGCCCACAATGTCCTGGTGTAAGGAGCCATGGTGGCTGGGACACTGAGGACCGTGTGAGGGACAATTACCAGCACCTCATCATGGCACTACTCTGTCTGGGTTATACGTTCCTAGTAGAGAGGTCTCTCCTCCGCTAGTGAACTCTGAAGGCAGGGACTGGGTCTCTCTATTCATGGCTATATCCCCAATGCCAACAATACAGTGGGTACCCAAACATGTTAGTCGAATAATTATAGAGGTATACAATAGGTACCTACTAAAAGTTAGTTGGATGAACATAAGCATATACAGAAAGCATTCAATAAATGTTGACTGGAGATATAGGGATATACACCCAATAACGCACCCAGTAAGTACTGATTGAATAAATATGGGTGTATATAGTAAGCACTCAATAAATGGCCAAATACAACCACAGGAGTATATACTAGGTACCAAATAAATGTTGGTTGGATAAAAATAGACATATGTGGTAGGTGTTCAATAGATATTGGTTGATTAAATAGAGAACTATACAGTAGGCATTCATGTATTGAATAAATATAGGGATATACAGTTGGTACCCAATACATGCTTGTTGGATAAATAATTTTTAAAAATTTATTTTCTGGCCAGGCGCAGTGGCTCATGCCTGTAATACCAGCACTCTGGGAGGCTGAGGCGGGCAGATCACAAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATAGTGAAACCCTATCTCTACTAAAAATACAAAAATTAGCCAGGCATAGTGGCACGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATGGCGCCACTGCACTCCAGCCTGGGTGACAGAACGAGACTTGTCTCAAAAAAAAAAATTTATTTTATATATTTTTTTACCTTTCCTATGGTGTTGATGGTTGGATAAATATAGGAGTATATAGTAGGTGTCCATATATAAAAGCTATTGAGGCCAGGCGCGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCCAAACCCCGTCTCTACTAAAAAAAATACAAAATTAGCCGGGCGTGGTGGCTGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATAGCGCCACTGCAGTCCAGCCTGGGCGACAAGAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAGCTATTGAATAAACACAGGGGATAGAGTAGGTGCCCAATAAATACTGGTTAGCTAACTATAAAGGTATATAGTAGGTGTCCATATACAGAAGCTATCTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAATGCAGTGGTGCGATCTTGGCTCACTGCAACCTCTGCCTCCTAGGTTCAAGTGATTCTCCTGTCTCAGCC
Task1_train_26549
Here is a variant affecting ACP5 (acid phosphatase 5, tartrate resistant) on Chromosome 19. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Spondyloenchondrodysplasia with immune dysregulation
CTGCTTGGATTTTATTTTTTTTTTATTTTTTATTTTTTTGAGATGGAGTCTCGCTCTTTCACCCAGGCAGGAGTGCAGTGGCGCTATCTTGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACTATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCGCCACGCCTGGCTAATTTTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCATGTTAGTCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCTGGCCGGGTTTTATAATCACATCCATGGATAAGGCAACTTGGTCATGGATGGGGTAAGAGATGGAGGCAAGGAACAGCAGCTCAGGGGAGCCCAGCCACTCTAACCAGGAGAACATAACACACCAGTGGCACTGGTTCAGCCTTGGCAACTATTCTTTTATTGAACATCAGTAACAGAAAGATGCTTGATTTAGGAGGAAGCTTTCCCTCCCTCCCTCCCCCATTGCACCCCGGAACTCAGCAAAGGTGAGCCAGCCACAGAGCATAACACTGTGGCTGGGACACATGTCCATGTGTGTTTCACATACGTGGGCATCTGTGCCACAAGGGTCATGTGGCACCACAGTTCATCAGCTGTGTTTCCCCTTCCTGCCCTGCTGCAGCGCCACAGGTTGGAGGAAAAGCCTGCCTGTGAGCAGGGTCCCGGCAGGGCCCACCCACCCAACAGTGGAGATCGGGCCTCAGAGCTGGGCAGTCATGGGAGTTCAGGGCCTGGCTCGCCTCGGCAGCCTGGTCTTAAAGAGGGACTTGCCCGAGGCCTCGATGTAAGTGACAGTCATCTCTTTGGAGCTGATCTCCACATAGGCAAAGCCACCCAGTGAGTCTTCAGTCCCATAGTGGAAGCGCAGATAGCCGTTGGGGACCTTGCGCTGGTGCCGCTTTGAGGGGTCCATGAAATTCCCAGCCCCACTCAGCACGTAGCCCACGCCATTCTCATCTTGCAGGTACTGAGGATGGAGGACAAGGGGTCAGTGGAGACCCAGCTTTGAGCAGAGCCCTGCCTAAGGTCCAGGGCTCGATCTGGCCCTAACCACAGAGTCACCTTGAGGTATGTAACCCCTCCTGGCTTCAATTTCCTGACTTTTAGGAGTGTATTAATCCTATTTCATAGGTAGAGCACTTAGTAAGAAATTGGTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGGGGTGGATTGCTTGAGCCCAGGAATTTGAGACCAGCCTGGGCAACATAGTGAGACCTTGCCTCTACAAAAAAAATGCGCAAGGGCCAGGTGCAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCGAGATCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAATATAAAAATTAGCAAGGTTTGGTGGCCCATGCTTGTAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGTTGAGATCGTGCCACTGCACTCCCTCTCAAAAAAAAAAAAAAAAGCAAAAATTAGCTGCATGTGGTGGCCCATGCCTGTAGTGTCAGCTACTCTGGAGGCTGAAGTGGGAGGTTCACCTGAGCCCGGGAGATTGAAGCTGCAGTAAGCCCCGATTGCACCACTGCACTCCAGCCTGGGTGAAAAACAATGAAACCTTGTCTCCAAAAAAAAAAAAAAAAAAGAGCTTAAAAAAGAAAGAAAGAAAGAAATTGGCAATTCGAAGATATTATTCTGGCTTTGGAGTGTTTTCCTGGTTAGACAGCAAGATTTGAGGGACAGTCTAGACATTCTGAAGGCCACAGGAGACCCTCAAACAGCAGGAGGACCCCAGCCATGTGGACATCAGCTGGGATGGGGACCCCCCTCACCCAGCTCCCACCCCACCCACAGGGCCCTCACCTGCAGATTGTGATCGTGGCCGCACAGGTAGGCAGTGACCCCGTATGTGGCCAGCAGTGGCCGTAGCTGCTTGACCAGGCAGTGGGTAGGCCCGTGCTCGGCTATGGACCACACGGGGTAGTGGCCAGCCACCAGCACGTAGTCCTCCCTGGCCGCCGCCAGCTGTTTCTTGAGCCAGGACAGCTGTGTGCGGGCCAGCTTCACGTCTCGGGGCCTCTCAGGCTGCTGGCTGAGGAAGTCATCTGAGTTGCCACATAGTGTCACTGTGTCCAGCATAAAAATGGCCACAGACACATTGGTCTGTGGGATCTTGAAGTGCAGGCGGTAGAAAGGGCTGGGGAAGTTCCTGTGGAGGGGATAGAGGTCGTGGGTGCACATCTTGGGCGCAGAAGTCCCAGGGTCAGCTCAAGCCACAGGGCCCCTGTGTCCCTGCTATGTGAGGATCTCGGAAGGCAGGGCTGAGGGTGGCTCACCAGCGCTTGGAGATCTTAGAGTATGCAATCTGGGCAGAGACATTGCCAAGGTGGTCATGGTTTCCGGCTAGCACGTACCAGGGCACTTTGCGAAGGGAGCGGTCAGAGAATACGTCCTCAAAGGTCTCCTGTAGCAAACAGATAGGGCAGGCCTCTTCCCTGGGGTCAGTGGCTATGCCGATCCTCCCACCAAGTCAGGATAAGGGAGACACTGAATGCTCCCGGCGCCCAAAGGTGCCCCATCACCTTCCCTCTGCCCTCACCAAAGGAAGGTCACTAGGTAAGGCGGCTTCTCCCCACTGCCCGCCCCCACCTCCTGCCCCACTCTGTTGGGCACAGACCTGGAACCTCTTGTCATTGATGTCTTGCACACCAGTGAAGTAAAAATTGTCCCCTAGAGACAGGATGAAGTCTGCACCCAGGATCTGCACAGTCCGAGCGATCTCCTTGGCATTGGCCATTTCCCGGGCCGTGTGGAATGGGGCATTGGGGACCCCTCCCCAGTCACCCACGGCTACAAAGCGCAGGGCAGGGGTGGCACCATCAGCCAGGGAGGGTAGCAACAAGGCTTGCAGGATGAGCAGCGCCGTCCACATGTCCATCTGGGAGAAGAGAGACAAGCATAGGTGGCCCGGGCTGTGACAAGGGCAGGGAGGCCTTGAGACCCCCGCCTGCCCTGAGATAGAGGGAGACTGCTTGCTGCAGGCTGCCCCTGCGGGAACCCCTTGGTGCCCTAATTCTCAGGACACACAAGCTGCACAAGGCTGCACAAGCTGGCTTAGGGAAGGGGGGCGCGGTCTGTGAGAGGGCGAGCTGTACCAAGATGGCCCTGCAGGCCCATTTCACCCTCCTTCCACCTAGCCTGCCCAGCACTCACCCAGGGGGAGACACAGGCCAGTCACCGGAGGCTCTGAGAGGCTGGTGGGCTCTAGAGTAGAACTGCCGGTCCCTGAGCCTTTATTCCCTGAGGAGGAAGTGGATCATTAGTGAGGATGATGCAGTTTCTCCGAGGGCTGTCCCGGGAGCCCTCCCCTTGGGTCATGTGAGCCCTGGACTTCCCTGGAGCAGGACACGGGATTGGGGTGGGGGTGGGAGGATCTGGGCACACGTGTGCAGCAGCCTCGGCCCACACAGCCTCCGGGTGGACCTGCAGGGGCCTGTTTGTGCTGTAGGCTTGACACGTCCAGGTATCTCTGTGTGTCTGTGTATCTCAGTGTGAGTGTGTGTGTGTGTGCACACTTGAGAGGCTGTGGCTGTGATTACCCAAGACACATCTCCTGCACCTTCTTTCTCTGAGTAAGGGCTTACCTGTGTGTGTCTGGGTGTGTCTTGCTTCCTGCGTGCAGCTGAGCATGCCTACCTGGGCCTCGGCTCTGTACCTGATGGTGTTGCTGCAGACATGTATGCTGAGCCTGCGAGGCCTGTGTGGCTTGTCTGCGATGCACGCCTGTGTTCTCACGTGGCACTGGGTGGGAATCCCTATGGATGGAGTTTTGTGTGTGTCCATGTGTGTGTGCCTGGGTTGCATCTCTAGGATGGGTTGCGTGTCTGGTGTGGGAGCTGTGTTTGACAACATCTGGGTGGGGGAC
CTGCTTGGATTTTATTTTTTTTTTATTTTTTATTTTTTTGAGATGGAGTCTCGCTCTTTCACCCAGGCAGGAGTGCAGTGGCGCTATCTTGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACTATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCGCCACGCCTGGCTAATTTTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCATGTTAGTCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCTGGCCGGGTTTTATAATCACATCCATGGATAAGGCAACTTGGTCATGGATGGGGTAAGAGATGGAGGCAAGGAACAGCAGCTCAGGGGAGCCCAGCCACTCTAACCAGGAGAACATAACACACCAGTGGCACTGGTTCAGCCTTGGCAACTATTCTTTTATTGAACATCAGTAACAGAAAGATGCTTGATTTAGGAGGAAGCTTTCCCTCCCTCCCTCCCCCATTGCACCCCGGAACTCAGCAAAGGTGAGCCAGCCACAGAGCATAACACTGTGGCTGGGACACATGTCCATGTGTGTTTCACATACGTGGGCATCTGTGCCACAAGGGTCATGTGGCACCACAGTTCATCAGCTGTGTTTCCCCTTCCTGCCCTGCTGCAGCGCCACAGGTTGGAGGAAAAGCCTGCCTGTGAGCAGGGTCCCGGCAGGGCCCACCCACCCAACAGTGGAGATCGGGCCTCAGAGCTGGGCAGTCATGGGAGTTCAGGGCCTGGCTCGCCTCGGCAGCCTGGTCTTAAAGAGGGACTTGCCCGAGGCCTCGATGTAAGTGACAGTCATCTCTTTGGAGCTGATCTCCACATAGGCAAAGCCACCCAGTGAGTCTTCAGTCCCATAGTGGAAGCGCAGATAGCCGTTGGGGACCTTGCGCTGGTGCCGCTTTGAGGGGTCCATGAAATTCCCAGCCCCACTCAGCACGTAGCCCACGCCATTCTCATCTTGCAGGTACTGAGGATGGAGGACAAGGGGTCAGTGGAGACCCAGCTTTGAGCAGAGCCCTGCCTAAGGTCCAGGGCTCGATCTGGCCCTAACCACAGAGTCACCTTGAGGTATGTAACCCCTCCTGGCTTCAATTTCCTGACTTTTAGGAGTGTATTAATCCTATTTCATAGGTAGAGCACTTAGTAAGAAATTGGTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGGGGTGGATTGCTTGAGCCCAGGAATTTGAGACCAGCCTGGGCAACATAGTGAGACCTTGCCTCTACAAAAAAAATGCGCAAGGGCCAGGTGCAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCGAGATCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAATATAAAAATTAGCAAGGTTTGGTGGCCCATGCTTGTAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGTTGAGATCGTGCCACTGCACTCCCTCTCAAAAAAAAAAAAAAAAGCAAAAATTAGCTGCATGTGGTGGCCCATGCCTGTAGTGTCAGCTACTCTGGAGGCTGAAGTGGGAGGTTCACCTGAGCCCGGGAGATTGAAGCTGCAGTAAGCCCCGATTGCACCACTGCACTCCAGCCTGGGTGAAAAACAATGAAACCTTGTCTCCAAAAAAAAAAAAAAAAAAGAGCTTAAAAAAGAAAGAAAGAAAGAAATTGGCAATTCGAAGATATTATTCTGGCTTTGGAGTGTTTTCCTGGTTAGACAGCAAGATTTGAGGGACAGTCTAGACATTCTGAAGGCCACAGGAGACCCTCAAACAGCAGGAGGACCCCAGCCATGTGGACATCAGCTGGGATGGGGACCCCCCTCACCCAGCTCCCACCCCACCCACAGGGCCCTCACCTGCAGATTGTGATTGTGGCCGCACAGGTAGGCAGTGACCCCGTATGTGGCCAGCAGTGGCCGTAGCTGCTTGACCAGGCAGTGGGTAGGCCCGTGCTCGGCTATGGACCACACGGGGTAGTGGCCAGCCACCAGCACGTAGTCCTCCCTGGCCGCCGCCAGCTGTTTCTTGAGCCAGGACAGCTGTGTGCGGGCCAGCTTCACGTCTCGGGGCCTCTCAGGCTGCTGGCTGAGGAAGTCATCTGAGTTGCCACATAGTGTCACTGTGTCCAGCATAAAAATGGCCACAGACACATTGGTCTGTGGGATCTTGAAGTGCAGGCGGTAGAAAGGGCTGGGGAAGTTCCTGTGGAGGGGATAGAGGTCGTGGGTGCACATCTTGGGCGCAGAAGTCCCAGGGTCAGCTCAAGCCACAGGGCCCCTGTGTCCCTGCTATGTGAGGATCTCGGAAGGCAGGGCTGAGGGTGGCTCACCAGCGCTTGGAGATCTTAGAGTATGCAATCTGGGCAGAGACATTGCCAAGGTGGTCATGGTTTCCGGCTAGCACGTACCAGGGCACTTTGCGAAGGGAGCGGTCAGAGAATACGTCCTCAAAGGTCTCCTGTAGCAAACAGATAGGGCAGGCCTCTTCCCTGGGGTCAGTGGCTATGCCGATCCTCCCACCAAGTCAGGATAAGGGAGACACTGAATGCTCCCGGCGCCCAAAGGTGCCCCATCACCTTCCCTCTGCCCTCACCAAAGGAAGGTCACTAGGTAAGGCGGCTTCTCCCCACTGCCCGCCCCCACCTCCTGCCCCACTCTGTTGGGCACAGACCTGGAACCTCTTGTCATTGATGTCTTGCACACCAGTGAAGTAAAAATTGTCCCCTAGAGACAGGATGAAGTCTGCACCCAGGATCTGCACAGTCCGAGCGATCTCCTTGGCATTGGCCATTTCCCGGGCCGTGTGGAATGGGGCATTGGGGACCCCTCCCCAGTCACCCACGGCTACAAAGCGCAGGGCAGGGGTGGCACCATCAGCCAGGGAGGGTAGCAACAAGGCTTGCAGGATGAGCAGCGCCGTCCACATGTCCATCTGGGAGAAGAGAGACAAGCATAGGTGGCCCGGGCTGTGACAAGGGCAGGGAGGCCTTGAGACCCCCGCCTGCCCTGAGATAGAGGGAGACTGCTTGCTGCAGGCTGCCCCTGCGGGAACCCCTTGGTGCCCTAATTCTCAGGACACACAAGCTGCACAAGGCTGCACAAGCTGGCTTAGGGAAGGGGGGCGCGGTCTGTGAGAGGGCGAGCTGTACCAAGATGGCCCTGCAGGCCCATTTCACCCTCCTTCCACCTAGCCTGCCCAGCACTCACCCAGGGGGAGACACAGGCCAGTCACCGGAGGCTCTGAGAGGCTGGTGGGCTCTAGAGTAGAACTGCCGGTCCCTGAGCCTTTATTCCCTGAGGAGGAAGTGGATCATTAGTGAGGATGATGCAGTTTCTCCGAGGGCTGTCCCGGGAGCCCTCCCCTTGGGTCATGTGAGCCCTGGACTTCCCTGGAGCAGGACACGGGATTGGGGTGGGGGTGGGAGGATCTGGGCACACGTGTGCAGCAGCCTCGGCCCACACAGCCTCCGGGTGGACCTGCAGGGGCCTGTTTGTGCTGTAGGCTTGACACGTCCAGGTATCTCTGTGTGTCTGTGTATCTCAGTGTGAGTGTGTGTGTGTGTGCACACTTGAGAGGCTGTGGCTGTGATTACCCAAGACACATCTCCTGCACCTTCTTTCTCTGAGTAAGGGCTTACCTGTGTGTGTCTGGGTGTGTCTTGCTTCCTGCGTGCAGCTGAGCATGCCTACCTGGGCCTCGGCTCTGTACCTGATGGTGTTGCTGCAGACATGTATGCTGAGCCTGCGAGGCCTGTGTGGCTTGTCTGCGATGCACGCCTGTGTTCTCACGTGGCACTGGGTGGGAATCCCTATGGATGGAGTTTTGTGTGTGTCCATGTGTGTGTGCCTGGGTTGCATCTCTAGGATGGGTTGCGTGTCTGGTGTGGGAGCTGTGTTTGACAACATCTGGGTGGGGGAC
Task1_train_26550
A sequence alteration has been identified in ACP5 (acid phosphatase 5, tartrate resistant) on Chromosome 19. Is it disease-inducing or harmless?
Pathogenic; Spondyloenchondrodysplasia with immune dysregulation
TTTTATTTTTTTTTTATTTTTTATTTTTTTGAGATGGAGTCTCGCTCTTTCACCCAGGCAGGAGTGCAGTGGCGCTATCTTGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACTATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCGCCACGCCTGGCTAATTTTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCATGTTAGTCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCTGGCCGGGTTTTATAATCACATCCATGGATAAGGCAACTTGGTCATGGATGGGGTAAGAGATGGAGGCAAGGAACAGCAGCTCAGGGGAGCCCAGCCACTCTAACCAGGAGAACATAACACACCAGTGGCACTGGTTCAGCCTTGGCAACTATTCTTTTATTGAACATCAGTAACAGAAAGATGCTTGATTTAGGAGGAAGCTTTCCCTCCCTCCCTCCCCCATTGCACCCCGGAACTCAGCAAAGGTGAGCCAGCCACAGAGCATAACACTGTGGCTGGGACACATGTCCATGTGTGTTTCACATACGTGGGCATCTGTGCCACAAGGGTCATGTGGCACCACAGTTCATCAGCTGTGTTTCCCCTTCCTGCCCTGCTGCAGCGCCACAGGTTGGAGGAAAAGCCTGCCTGTGAGCAGGGTCCCGGCAGGGCCCACCCACCCAACAGTGGAGATCGGGCCTCAGAGCTGGGCAGTCATGGGAGTTCAGGGCCTGGCTCGCCTCGGCAGCCTGGTCTTAAAGAGGGACTTGCCCGAGGCCTCGATGTAAGTGACAGTCATCTCTTTGGAGCTGATCTCCACATAGGCAAAGCCACCCAGTGAGTCTTCAGTCCCATAGTGGAAGCGCAGATAGCCGTTGGGGACCTTGCGCTGGTGCCGCTTTGAGGGGTCCATGAAATTCCCAGCCCCACTCAGCACGTAGCCCACGCCATTCTCATCTTGCAGGTACTGAGGATGGAGGACAAGGGGTCAGTGGAGACCCAGCTTTGAGCAGAGCCCTGCCTAAGGTCCAGGGCTCGATCTGGCCCTAACCACAGAGTCACCTTGAGGTATGTAACCCCTCCTGGCTTCAATTTCCTGACTTTTAGGAGTGTATTAATCCTATTTCATAGGTAGAGCACTTAGTAAGAAATTGGTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGGGGTGGATTGCTTGAGCCCAGGAATTTGAGACCAGCCTGGGCAACATAGTGAGACCTTGCCTCTACAAAAAAAATGCGCAAGGGCCAGGTGCAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCGAGATCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAATATAAAAATTAGCAAGGTTTGGTGGCCCATGCTTGTAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGTTGAGATCGTGCCACTGCACTCCCTCTCAAAAAAAAAAAAAAAAGCAAAAATTAGCTGCATGTGGTGGCCCATGCCTGTAGTGTCAGCTACTCTGGAGGCTGAAGTGGGAGGTTCACCTGAGCCCGGGAGATTGAAGCTGCAGTAAGCCCCGATTGCACCACTGCACTCCAGCCTGGGTGAAAAACAATGAAACCTTGTCTCCAAAAAAAAAAAAAAAAAAGAGCTTAAAAAAGAAAGAAAGAAAGAAATTGGCAATTCGAAGATATTATTCTGGCTTTGGAGTGTTTTCCTGGTTAGACAGCAAGATTTGAGGGACAGTCTAGACATTCTGAAGGCCACAGGAGACCCTCAAACAGCAGGAGGACCCCAGCCATGTGGACATCAGCTGGGATGGGGACCCCCCTCACCCAGCTCCCACCCCACCCACAGGGCCCTCACCTGCAGATTGTGATCGTGGCCGCACAGGTAGGCAGTGACCCCGTATGTGGCCAGCAGTGGCCGTAGCTGCTTGACCAGGCAGTGGGTAGGCCCGTGCTCGGCTATGGACCACACGGGGTAGTGGCCAGCCACCAGCACGTAGTCCTCCCTGGCCGCCGCCAGCTGTTTCTTGAGCCAGGACAGCTGTGTGCGGGCCAGCTTCACGTCTCGGGGCCTCTCAGGCTGCTGGCTGAGGAAGTCATCTGAGTTGCCACATAGTGTCACTGTGTCCAGCATAAAAATGGCCACAGACACATTGGTCTGTGGGATCTTGAAGTGCAGGCGGTAGAAAGGGCTGGGGAAGTTCCTGTGGAGGGGATAGAGGTCGTGGGTGCACATCTTGGGCGCAGAAGTCCCAGGGTCAGCTCAAGCCACAGGGCCCCTGTGTCCCTGCTATGTGAGGATCTCGGAAGGCAGGGCTGAGGGTGGCTCACCAGCGCTTGGAGATCTTAGAGTATGCAATCTGGGCAGAGACATTGCCAAGGTGGTCATGGTTTCCGGCTAGCACGTACCAGGGCACTTTGCGAAGGGAGCGGTCAGAGAATACGTCCTCAAAGGTCTCCTGTAGCAAACAGATAGGGCAGGCCTCTTCCCTGGGGTCAGTGGCTATGCCGATCCTCCCACCAAGTCAGGATAAGGGAGACACTGAATGCTCCCGGCGCCCAAAGGTGCCCCATCACCTTCCCTCTGCCCTCACCAAAGGAAGGTCACTAGGTAAGGCGGCTTCTCCCCACTGCCCGCCCCCACCTCCTGCCCCACTCTGTTGGGCACAGACCTGGAACCTCTTGTCATTGATGTCTTGCACACCAGTGAAGTAAAAATTGTCCCCTAGAGACAGGATGAAGTCTGCACCCAGGATCTGCACAGTCCGAGCGATCTCCTTGGCATTGGCCATTTCCCGGGCCGTGTGGAATGGGGCATTGGGGACCCCTCCCCAGTCACCCACGGCTACAAAGCGCAGGGCAGGGGTGGCACCATCAGCCAGGGAGGGTAGCAACAAGGCTTGCAGGATGAGCAGCGCCGTCCACATGTCCATCTGGGAGAAGAGAGACAAGCATAGGTGGCCCGGGCTGTGACAAGGGCAGGGAGGCCTTGAGACCCCCGCCTGCCCTGAGATAGAGGGAGACTGCTTGCTGCAGGCTGCCCCTGCGGGAACCCCTTGGTGCCCTAATTCTCAGGACACACAAGCTGCACAAGGCTGCACAAGCTGGCTTAGGGAAGGGGGGCGCGGTCTGTGAGAGGGCGAGCTGTACCAAGATGGCCCTGCAGGCCCATTTCACCCTCCTTCCACCTAGCCTGCCCAGCACTCACCCAGGGGGAGACACAGGCCAGTCACCGGAGGCTCTGAGAGGCTGGTGGGCTCTAGAGTAGAACTGCCGGTCCCTGAGCCTTTATTCCCTGAGGAGGAAGTGGATCATTAGTGAGGATGATGCAGTTTCTCCGAGGGCTGTCCCGGGAGCCCTCCCCTTGGGTCATGTGAGCCCTGGACTTCCCTGGAGCAGGACACGGGATTGGGGTGGGGGTGGGAGGATCTGGGCACACGTGTGCAGCAGCCTCGGCCCACACAGCCTCCGGGTGGACCTGCAGGGGCCTGTTTGTGCTGTAGGCTTGACACGTCCAGGTATCTCTGTGTGTCTGTGTATCTCAGTGTGAGTGTGTGTGTGTGTGCACACTTGAGAGGCTGTGGCTGTGATTACCCAAGACACATCTCCTGCACCTTCTTTCTCTGAGTAAGGGCTTACCTGTGTGTGTCTGGGTGTGTCTTGCTTCCTGCGTGCAGCTGAGCATGCCTACCTGGGCCTCGGCTCTGTACCTGATGGTGTTGCTGCAGACATGTATGCTGAGCCTGCGAGGCCTGTGTGGCTTGTCTGCGATGCACGCCTGTGTTCTCACGTGGCACTGGGTGGGAATCCCTATGGATGGAGTTTTGTGTGTGTCCATGTGTGTGTGCCTGGGTTGCATCTCTAGGATGGGTTGCGTGTCTGGTGTGGGAGCTGTGTTTGACAACATCTGGGTGGGGGACTCCGCGTGT
TTTTATTTTTTTTTTATTTTTTATTTTTTTGAGATGGAGTCTCGCTCTTTCACCCAGGCAGGAGTGCAGTGGCGCTATCTTGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACTATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCGCCACGCCTGGCTAATTTTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCATGTTAGTCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCTGGCCGGGTTTTATAATCACATCCATGGATAAGGCAACTTGGTCATGGATGGGGTAAGAGATGGAGGCAAGGAACAGCAGCTCAGGGGAGCCCAGCCACTCTAACCAGGAGAACATAACACACCAGTGGCACTGGTTCAGCCTTGGCAACTATTCTTTTATTGAACATCAGTAACAGAAAGATGCTTGATTTAGGAGGAAGCTTTCCCTCCCTCCCTCCCCCATTGCACCCCGGAACTCAGCAAAGGTGAGCCAGCCACAGAGCATAACACTGTGGCTGGGACACATGTCCATGTGTGTTTCACATACGTGGGCATCTGTGCCACAAGGGTCATGTGGCACCACAGTTCATCAGCTGTGTTTCCCCTTCCTGCCCTGCTGCAGCGCCACAGGTTGGAGGAAAAGCCTGCCTGTGAGCAGGGTCCCGGCAGGGCCCACCCACCCAACAGTGGAGATCGGGCCTCAGAGCTGGGCAGTCATGGGAGTTCAGGGCCTGGCTCGCCTCGGCAGCCTGGTCTTAAAGAGGGACTTGCCCGAGGCCTCGATGTAAGTGACAGTCATCTCTTTGGAGCTGATCTCCACATAGGCAAAGCCACCCAGTGAGTCTTCAGTCCCATAGTGGAAGCGCAGATAGCCGTTGGGGACCTTGCGCTGGTGCCGCTTTGAGGGGTCCATGAAATTCCCAGCCCCACTCAGCACGTAGCCCACGCCATTCTCATCTTGCAGGTACTGAGGATGGAGGACAAGGGGTCAGTGGAGACCCAGCTTTGAGCAGAGCCCTGCCTAAGGTCCAGGGCTCGATCTGGCCCTAACCACAGAGTCACCTTGAGGTATGTAACCCCTCCTGGCTTCAATTTCCTGACTTTTAGGAGTGTATTAATCCTATTTCATAGGTAGAGCACTTAGTAAGAAATTGGTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGGGGTGGATTGCTTGAGCCCAGGAATTTGAGACCAGCCTGGGCAACATAGTGAGACCTTGCCTCTACAAAAAAAATGCGCAAGGGCCAGGTGCAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCGAGATCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAATATAAAAATTAGCAAGGTTTGGTGGCCCATGCTTGTAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGTTGAGATCGTGCCACTGCACTCCCTCTCAAAAAAAAAAAAAAAAGCAAAAATTAGCTGCATGTGGTGGCCCATGCCTGTAGTGTCAGCTACTCTGGAGGCTGAAGTGGGAGGTTCACCTGAGCCCGGGAGATTGAAGCTGCAGTAAGCCCCGATTGCACCACTGCACTCCAGCCTGGGTGAAAAACAATGAAACCTTGTCTCCAAAAAAAAAAAAAAAAAAGAGCTTAAAAAAGAAAGAAAGAAAGAAATTGGCAATTCGAAGATATTATTCTGGCTTTGGAGTGTTTTCCTGGTTAGACAGCAAGATTTGAGGGACAGTCTAGACATTCTGAAGGCCACAGGAGACCCTCAAACAGCAGGAGGACCCCAGCCATGTGGACATCAGCTGGGATGGGGACCCCCCTCACCCAGCTCCCACCCCACCCACAGGGCCCTCACCTGCAGATTGTGATCGTGGCCGCGCAGGTAGGCAGTGACCCCGTATGTGGCCAGCAGTGGCCGTAGCTGCTTGACCAGGCAGTGGGTAGGCCCGTGCTCGGCTATGGACCACACGGGGTAGTGGCCAGCCACCAGCACGTAGTCCTCCCTGGCCGCCGCCAGCTGTTTCTTGAGCCAGGACAGCTGTGTGCGGGCCAGCTTCACGTCTCGGGGCCTCTCAGGCTGCTGGCTGAGGAAGTCATCTGAGTTGCCACATAGTGTCACTGTGTCCAGCATAAAAATGGCCACAGACACATTGGTCTGTGGGATCTTGAAGTGCAGGCGGTAGAAAGGGCTGGGGAAGTTCCTGTGGAGGGGATAGAGGTCGTGGGTGCACATCTTGGGCGCAGAAGTCCCAGGGTCAGCTCAAGCCACAGGGCCCCTGTGTCCCTGCTATGTGAGGATCTCGGAAGGCAGGGCTGAGGGTGGCTCACCAGCGCTTGGAGATCTTAGAGTATGCAATCTGGGCAGAGACATTGCCAAGGTGGTCATGGTTTCCGGCTAGCACGTACCAGGGCACTTTGCGAAGGGAGCGGTCAGAGAATACGTCCTCAAAGGTCTCCTGTAGCAAACAGATAGGGCAGGCCTCTTCCCTGGGGTCAGTGGCTATGCCGATCCTCCCACCAAGTCAGGATAAGGGAGACACTGAATGCTCCCGGCGCCCAAAGGTGCCCCATCACCTTCCCTCTGCCCTCACCAAAGGAAGGTCACTAGGTAAGGCGGCTTCTCCCCACTGCCCGCCCCCACCTCCTGCCCCACTCTGTTGGGCACAGACCTGGAACCTCTTGTCATTGATGTCTTGCACACCAGTGAAGTAAAAATTGTCCCCTAGAGACAGGATGAAGTCTGCACCCAGGATCTGCACAGTCCGAGCGATCTCCTTGGCATTGGCCATTTCCCGGGCCGTGTGGAATGGGGCATTGGGGACCCCTCCCCAGTCACCCACGGCTACAAAGCGCAGGGCAGGGGTGGCACCATCAGCCAGGGAGGGTAGCAACAAGGCTTGCAGGATGAGCAGCGCCGTCCACATGTCCATCTGGGAGAAGAGAGACAAGCATAGGTGGCCCGGGCTGTGACAAGGGCAGGGAGGCCTTGAGACCCCCGCCTGCCCTGAGATAGAGGGAGACTGCTTGCTGCAGGCTGCCCCTGCGGGAACCCCTTGGTGCCCTAATTCTCAGGACACACAAGCTGCACAAGGCTGCACAAGCTGGCTTAGGGAAGGGGGGCGCGGTCTGTGAGAGGGCGAGCTGTACCAAGATGGCCCTGCAGGCCCATTTCACCCTCCTTCCACCTAGCCTGCCCAGCACTCACCCAGGGGGAGACACAGGCCAGTCACCGGAGGCTCTGAGAGGCTGGTGGGCTCTAGAGTAGAACTGCCGGTCCCTGAGCCTTTATTCCCTGAGGAGGAAGTGGATCATTAGTGAGGATGATGCAGTTTCTCCGAGGGCTGTCCCGGGAGCCCTCCCCTTGGGTCATGTGAGCCCTGGACTTCCCTGGAGCAGGACACGGGATTGGGGTGGGGGTGGGAGGATCTGGGCACACGTGTGCAGCAGCCTCGGCCCACACAGCCTCCGGGTGGACCTGCAGGGGCCTGTTTGTGCTGTAGGCTTGACACGTCCAGGTATCTCTGTGTGTCTGTGTATCTCAGTGTGAGTGTGTGTGTGTGTGCACACTTGAGAGGCTGTGGCTGTGATTACCCAAGACACATCTCCTGCACCTTCTTTCTCTGAGTAAGGGCTTACCTGTGTGTGTCTGGGTGTGTCTTGCTTCCTGCGTGCAGCTGAGCATGCCTACCTGGGCCTCGGCTCTGTACCTGATGGTGTTGCTGCAGACATGTATGCTGAGCCTGCGAGGCCTGTGTGGCTTGTCTGCGATGCACGCCTGTGTTCTCACGTGGCACTGGGTGGGAATCCCTATGGATGGAGTTTTGTGTGTGTCCATGTGTGTGTGCCTGGGTTGCATCTCTAGGATGGGTTGCGTGTCTGGTGTGGGAGCTGTGTTTGACAACATCTGGGTGGGGGACTCCGCGTGT
Task1_train_26551
Here is a variant affecting ACP5 (acid phosphatase 5, tartrate resistant) on Chromosome 19. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Spondyloenchondrodysplasia with immune dysregulation
TGGCGCTATCTTGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACTATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCGCCACGCCTGGCTAATTTTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCATGTTAGTCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCTGGCCGGGTTTTATAATCACATCCATGGATAAGGCAACTTGGTCATGGATGGGGTAAGAGATGGAGGCAAGGAACAGCAGCTCAGGGGAGCCCAGCCACTCTAACCAGGAGAACATAACACACCAGTGGCACTGGTTCAGCCTTGGCAACTATTCTTTTATTGAACATCAGTAACAGAAAGATGCTTGATTTAGGAGGAAGCTTTCCCTCCCTCCCTCCCCCATTGCACCCCGGAACTCAGCAAAGGTGAGCCAGCCACAGAGCATAACACTGTGGCTGGGACACATGTCCATGTGTGTTTCACATACGTGGGCATCTGTGCCACAAGGGTCATGTGGCACCACAGTTCATCAGCTGTGTTTCCCCTTCCTGCCCTGCTGCAGCGCCACAGGTTGGAGGAAAAGCCTGCCTGTGAGCAGGGTCCCGGCAGGGCCCACCCACCCAACAGTGGAGATCGGGCCTCAGAGCTGGGCAGTCATGGGAGTTCAGGGCCTGGCTCGCCTCGGCAGCCTGGTCTTAAAGAGGGACTTGCCCGAGGCCTCGATGTAAGTGACAGTCATCTCTTTGGAGCTGATCTCCACATAGGCAAAGCCACCCAGTGAGTCTTCAGTCCCATAGTGGAAGCGCAGATAGCCGTTGGGGACCTTGCGCTGGTGCCGCTTTGAGGGGTCCATGAAATTCCCAGCCCCACTCAGCACGTAGCCCACGCCATTCTCATCTTGCAGGTACTGAGGATGGAGGACAAGGGGTCAGTGGAGACCCAGCTTTGAGCAGAGCCCTGCCTAAGGTCCAGGGCTCGATCTGGCCCTAACCACAGAGTCACCTTGAGGTATGTAACCCCTCCTGGCTTCAATTTCCTGACTTTTAGGAGTGTATTAATCCTATTTCATAGGTAGAGCACTTAGTAAGAAATTGGTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGGGGTGGATTGCTTGAGCCCAGGAATTTGAGACCAGCCTGGGCAACATAGTGAGACCTTGCCTCTACAAAAAAAATGCGCAAGGGCCAGGTGCAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCGAGATCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAATATAAAAATTAGCAAGGTTTGGTGGCCCATGCTTGTAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGTTGAGATCGTGCCACTGCACTCCCTCTCAAAAAAAAAAAAAAAAGCAAAAATTAGCTGCATGTGGTGGCCCATGCCTGTAGTGTCAGCTACTCTGGAGGCTGAAGTGGGAGGTTCACCTGAGCCCGGGAGATTGAAGCTGCAGTAAGCCCCGATTGCACCACTGCACTCCAGCCTGGGTGAAAAACAATGAAACCTTGTCTCCAAAAAAAAAAAAAAAAAAGAGCTTAAAAAAGAAAGAAAGAAAGAAATTGGCAATTCGAAGATATTATTCTGGCTTTGGAGTGTTTTCCTGGTTAGACAGCAAGATTTGAGGGACAGTCTAGACATTCTGAAGGCCACAGGAGACCCTCAAACAGCAGGAGGACCCCAGCCATGTGGACATCAGCTGGGATGGGGACCCCCCTCACCCAGCTCCCACCCCACCCACAGGGCCCTCACCTGCAGATTGTGATCGTGGCCGCACAGGTAGGCAGTGACCCCGTATGTGGCCAGCAGTGGCCGTAGCTGCTTGACCAGGCAGTGGGTAGGCCCGTGCTCGGCTATGGACCACACGGGGTAGTGGCCAGCCACCAGCACGTAGTCCTCCCTGGCCGCCGCCAGCTGTTTCTTGAGCCAGGACAGCTGTGTGCGGGCCAGCTTCACGTCTCGGGGCCTCTCAGGCTGCTGGCTGAGGAAGTCATCTGAGTTGCCACATAGTGTCACTGTGTCCAGCATAAAAATGGCCACAGACACATTGGTCTGTGGGATCTTGAAGTGCAGGCGGTAGAAAGGGCTGGGGAAGTTCCTGTGGAGGGGATAGAGGTCGTGGGTGCACATCTTGGGCGCAGAAGTCCCAGGGTCAGCTCAAGCCACAGGGCCCCTGTGTCCCTGCTATGTGAGGATCTCGGAAGGCAGGGCTGAGGGTGGCTCACCAGCGCTTGGAGATCTTAGAGTATGCAATCTGGGCAGAGACATTGCCAAGGTGGTCATGGTTTCCGGCTAGCACGTACCAGGGCACTTTGCGAAGGGAGCGGTCAGAGAATACGTCCTCAAAGGTCTCCTGTAGCAAACAGATAGGGCAGGCCTCTTCCCTGGGGTCAGTGGCTATGCCGATCCTCCCACCAAGTCAGGATAAGGGAGACACTGAATGCTCCCGGCGCCCAAAGGTGCCCCATCACCTTCCCTCTGCCCTCACCAAAGGAAGGTCACTAGGTAAGGCGGCTTCTCCCCACTGCCCGCCCCCACCTCCTGCCCCACTCTGTTGGGCACAGACCTGGAACCTCTTGTCATTGATGTCTTGCACACCAGTGAAGTAAAAATTGTCCCCTAGAGACAGGATGAAGTCTGCACCCAGGATCTGCACAGTCCGAGCGATCTCCTTGGCATTGGCCATTTCCCGGGCCGTGTGGAATGGGGCATTGGGGACCCCTCCCCAGTCACCCACGGCTACAAAGCGCAGGGCAGGGGTGGCACCATCAGCCAGGGAGGGTAGCAACAAGGCTTGCAGGATGAGCAGCGCCGTCCACATGTCCATCTGGGAGAAGAGAGACAAGCATAGGTGGCCCGGGCTGTGACAAGGGCAGGGAGGCCTTGAGACCCCCGCCTGCCCTGAGATAGAGGGAGACTGCTTGCTGCAGGCTGCCCCTGCGGGAACCCCTTGGTGCCCTAATTCTCAGGACACACAAGCTGCACAAGGCTGCACAAGCTGGCTTAGGGAAGGGGGGCGCGGTCTGTGAGAGGGCGAGCTGTACCAAGATGGCCCTGCAGGCCCATTTCACCCTCCTTCCACCTAGCCTGCCCAGCACTCACCCAGGGGGAGACACAGGCCAGTCACCGGAGGCTCTGAGAGGCTGGTGGGCTCTAGAGTAGAACTGCCGGTCCCTGAGCCTTTATTCCCTGAGGAGGAAGTGGATCATTAGTGAGGATGATGCAGTTTCTCCGAGGGCTGTCCCGGGAGCCCTCCCCTTGGGTCATGTGAGCCCTGGACTTCCCTGGAGCAGGACACGGGATTGGGGTGGGGGTGGGAGGATCTGGGCACACGTGTGCAGCAGCCTCGGCCCACACAGCCTCCGGGTGGACCTGCAGGGGCCTGTTTGTGCTGTAGGCTTGACACGTCCAGGTATCTCTGTGTGTCTGTGTATCTCAGTGTGAGTGTGTGTGTGTGTGCACACTTGAGAGGCTGTGGCTGTGATTACCCAAGACACATCTCCTGCACCTTCTTTCTCTGAGTAAGGGCTTACCTGTGTGTGTCTGGGTGTGTCTTGCTTCCTGCGTGCAGCTGAGCATGCCTACCTGGGCCTCGGCTCTGTACCTGATGGTGTTGCTGCAGACATGTATGCTGAGCCTGCGAGGCCTGTGTGGCTTGTCTGCGATGCACGCCTGTGTTCTCACGTGGCACTGGGTGGGAATCCCTATGGATGGAGTTTTGTGTGTGTCCATGTGTGTGTGCCTGGGTTGCATCTCTAGGATGGGTTGCGTGTCTGGTGTGGGAGCTGTGTTTGACAACATCTGGGTGGGGGACTCCGCGTGTGTCCCCGTCCTCCCCCTGCCCTCTCTCCATCCCACACATAAACACCAACGGGCTTCCCTTTTCCAGGAA
TGGCGCTATCTTGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACTATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCGCCACGCCTGGCTAATTTTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCATGTTAGTCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCTGGCCGGGTTTTATAATCACATCCATGGATAAGGCAACTTGGTCATGGATGGGGTAAGAGATGGAGGCAAGGAACAGCAGCTCAGGGGAGCCCAGCCACTCTAACCAGGAGAACATAACACACCAGTGGCACTGGTTCAGCCTTGGCAACTATTCTTTTATTGAACATCAGTAACAGAAAGATGCTTGATTTAGGAGGAAGCTTTCCCTCCCTCCCTCCCCCATTGCACCCCGGAACTCAGCAAAGGTGAGCCAGCCACAGAGCATAACACTGTGGCTGGGACACATGTCCATGTGTGTTTCACATACGTGGGCATCTGTGCCACAAGGGTCATGTGGCACCACAGTTCATCAGCTGTGTTTCCCCTTCCTGCCCTGCTGCAGCGCCACAGGTTGGAGGAAAAGCCTGCCTGTGAGCAGGGTCCCGGCAGGGCCCACCCACCCAACAGTGGAGATCGGGCCTCAGAGCTGGGCAGTCATGGGAGTTCAGGGCCTGGCTCGCCTCGGCAGCCTGGTCTTAAAGAGGGACTTGCCCGAGGCCTCGATGTAAGTGACAGTCATCTCTTTGGAGCTGATCTCCACATAGGCAAAGCCACCCAGTGAGTCTTCAGTCCCATAGTGGAAGCGCAGATAGCCGTTGGGGACCTTGCGCTGGTGCCGCTTTGAGGGGTCCATGAAATTCCCAGCCCCACTCAGCACGTAGCCCACGCCATTCTCATCTTGCAGGTACTGAGGATGGAGGACAAGGGGTCAGTGGAGACCCAGCTTTGAGCAGAGCCCTGCCTAAGGTCCAGGGCTCGATCTGGCCCTAACCACAGAGTCACCTTGAGGTATGTAACCCCTCCTGGCTTCAATTTCCTGACTTTTAGGAGTGTATTAATCCTATTTCATAGGTAGAGCACTTAGTAAGAAATTGGTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGGGGTGGATTGCTTGAGCCCAGGAATTTGAGACCAGCCTGGGCAACATAGTGAGACCTTGCCTCTACAAAAAAAATGCGCAAGGGCCAGGTGCAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCGAGATCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAATATAAAAATTAGCAAGGTTTGGTGGCCCATGCTTGTAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGTTGAGATCGTGCCACTGCACTCCCTCTCAAAAAAAAAAAAAAAAGCAAAAATTAGCTGCATGTGGTGGCCCATGCCTGTAGTGTCAGCTACTCTGGAGGCTGAAGTGGGAGGTTCACCTGAGCCCGGGAGATTGAAGCTGCAGTAAGCCCCGATTGCACCACTGCACTCCAGCCTGGGTGAAAAACAATGAAACCTTGTCTCCAAAAAAAAAAAAAAAAAAGAGCTTAAAAAAGAAAGAAAGAAAGAAATTGGCAATTCGAAGATATTATTCTGGCTTTGGAGTGTTTTCCTGGTTAGACAGCAAGATTTGAGGGACAGTCTAGACATTCTGAAGGCCACAGGAGACCCTCAAACAGCAGGAGGACCCCAGCCATGTGGACATCAGCTGGGATGGGGACCCCCCTCACCCAGCTCCCACCCCACCCACAGGGCCCTCACCTGCAGATTGTGATCGTGGCCGCACAGGTAGGCAGTGACCCCGTATGTGGCCAGCAGTGGCCGTAGCTGCTTGACCAGGCAGTGGGTAGGCCGGTGCTCGGCTATGGACCACACGGGGTAGTGGCCAGCCACCAGCACGTAGTCCTCCCTGGCCGCCGCCAGCTGTTTCTTGAGCCAGGACAGCTGTGTGCGGGCCAGCTTCACGTCTCGGGGCCTCTCAGGCTGCTGGCTGAGGAAGTCATCTGAGTTGCCACATAGTGTCACTGTGTCCAGCATAAAAATGGCCACAGACACATTGGTCTGTGGGATCTTGAAGTGCAGGCGGTAGAAAGGGCTGGGGAAGTTCCTGTGGAGGGGATAGAGGTCGTGGGTGCACATCTTGGGCGCAGAAGTCCCAGGGTCAGCTCAAGCCACAGGGCCCCTGTGTCCCTGCTATGTGAGGATCTCGGAAGGCAGGGCTGAGGGTGGCTCACCAGCGCTTGGAGATCTTAGAGTATGCAATCTGGGCAGAGACATTGCCAAGGTGGTCATGGTTTCCGGCTAGCACGTACCAGGGCACTTTGCGAAGGGAGCGGTCAGAGAATACGTCCTCAAAGGTCTCCTGTAGCAAACAGATAGGGCAGGCCTCTTCCCTGGGGTCAGTGGCTATGCCGATCCTCCCACCAAGTCAGGATAAGGGAGACACTGAATGCTCCCGGCGCCCAAAGGTGCCCCATCACCTTCCCTCTGCCCTCACCAAAGGAAGGTCACTAGGTAAGGCGGCTTCTCCCCACTGCCCGCCCCCACCTCCTGCCCCACTCTGTTGGGCACAGACCTGGAACCTCTTGTCATTGATGTCTTGCACACCAGTGAAGTAAAAATTGTCCCCTAGAGACAGGATGAAGTCTGCACCCAGGATCTGCACAGTCCGAGCGATCTCCTTGGCATTGGCCATTTCCCGGGCCGTGTGGAATGGGGCATTGGGGACCCCTCCCCAGTCACCCACGGCTACAAAGCGCAGGGCAGGGGTGGCACCATCAGCCAGGGAGGGTAGCAACAAGGCTTGCAGGATGAGCAGCGCCGTCCACATGTCCATCTGGGAGAAGAGAGACAAGCATAGGTGGCCCGGGCTGTGACAAGGGCAGGGAGGCCTTGAGACCCCCGCCTGCCCTGAGATAGAGGGAGACTGCTTGCTGCAGGCTGCCCCTGCGGGAACCCCTTGGTGCCCTAATTCTCAGGACACACAAGCTGCACAAGGCTGCACAAGCTGGCTTAGGGAAGGGGGGCGCGGTCTGTGAGAGGGCGAGCTGTACCAAGATGGCCCTGCAGGCCCATTTCACCCTCCTTCCACCTAGCCTGCCCAGCACTCACCCAGGGGGAGACACAGGCCAGTCACCGGAGGCTCTGAGAGGCTGGTGGGCTCTAGAGTAGAACTGCCGGTCCCTGAGCCTTTATTCCCTGAGGAGGAAGTGGATCATTAGTGAGGATGATGCAGTTTCTCCGAGGGCTGTCCCGGGAGCCCTCCCCTTGGGTCATGTGAGCCCTGGACTTCCCTGGAGCAGGACACGGGATTGGGGTGGGGGTGGGAGGATCTGGGCACACGTGTGCAGCAGCCTCGGCCCACACAGCCTCCGGGTGGACCTGCAGGGGCCTGTTTGTGCTGTAGGCTTGACACGTCCAGGTATCTCTGTGTGTCTGTGTATCTCAGTGTGAGTGTGTGTGTGTGTGCACACTTGAGAGGCTGTGGCTGTGATTACCCAAGACACATCTCCTGCACCTTCTTTCTCTGAGTAAGGGCTTACCTGTGTGTGTCTGGGTGTGTCTTGCTTCCTGCGTGCAGCTGAGCATGCCTACCTGGGCCTCGGCTCTGTACCTGATGGTGTTGCTGCAGACATGTATGCTGAGCCTGCGAGGCCTGTGTGGCTTGTCTGCGATGCACGCCTGTGTTCTCACGTGGCACTGGGTGGGAATCCCTATGGATGGAGTTTTGTGTGTGTCCATGTGTGTGTGCCTGGGTTGCATCTCTAGGATGGGTTGCGTGTCTGGTGTGGGAGCTGTGTTTGACAACATCTGGGTGGGGGACTCCGCGTGTGTCCCCGTCCTCCCCCTGCCCTCTCTCCATCCCACACATAAACACCAACGGGCTTCCCTTTTCCAGGAA
Task1_train_26552
A genomic change on Chromosome 19 affects ACP5 (acid phosphatase 5, tartrate resistant). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Spondyloenchondrodysplasia with immune dysregulation
AACACTGTGGCTGGGACACATGTCCATGTGTGTTTCACATACGTGGGCATCTGTGCCACAAGGGTCATGTGGCACCACAGTTCATCAGCTGTGTTTCCCCTTCCTGCCCTGCTGCAGCGCCACAGGTTGGAGGAAAAGCCTGCCTGTGAGCAGGGTCCCGGCAGGGCCCACCCACCCAACAGTGGAGATCGGGCCTCAGAGCTGGGCAGTCATGGGAGTTCAGGGCCTGGCTCGCCTCGGCAGCCTGGTCTTAAAGAGGGACTTGCCCGAGGCCTCGATGTAAGTGACAGTCATCTCTTTGGAGCTGATCTCCACATAGGCAAAGCCACCCAGTGAGTCTTCAGTCCCATAGTGGAAGCGCAGATAGCCGTTGGGGACCTTGCGCTGGTGCCGCTTTGAGGGGTCCATGAAATTCCCAGCCCCACTCAGCACGTAGCCCACGCCATTCTCATCTTGCAGGTACTGAGGATGGAGGACAAGGGGTCAGTGGAGACCCAGCTTTGAGCAGAGCCCTGCCTAAGGTCCAGGGCTCGATCTGGCCCTAACCACAGAGTCACCTTGAGGTATGTAACCCCTCCTGGCTTCAATTTCCTGACTTTTAGGAGTGTATTAATCCTATTTCATAGGTAGAGCACTTAGTAAGAAATTGGTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGGGGTGGATTGCTTGAGCCCAGGAATTTGAGACCAGCCTGGGCAACATAGTGAGACCTTGCCTCTACAAAAAAAATGCGCAAGGGCCAGGTGCAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCGAGATCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAATATAAAAATTAGCAAGGTTTGGTGGCCCATGCTTGTAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGTTGAGATCGTGCCACTGCACTCCCTCTCAAAAAAAAAAAAAAAAGCAAAAATTAGCTGCATGTGGTGGCCCATGCCTGTAGTGTCAGCTACTCTGGAGGCTGAAGTGGGAGGTTCACCTGAGCCCGGGAGATTGAAGCTGCAGTAAGCCCCGATTGCACCACTGCACTCCAGCCTGGGTGAAAAACAATGAAACCTTGTCTCCAAAAAAAAAAAAAAAAAAGAGCTTAAAAAAGAAAGAAAGAAAGAAATTGGCAATTCGAAGATATTATTCTGGCTTTGGAGTGTTTTCCTGGTTAGACAGCAAGATTTGAGGGACAGTCTAGACATTCTGAAGGCCACAGGAGACCCTCAAACAGCAGGAGGACCCCAGCCATGTGGACATCAGCTGGGATGGGGACCCCCCTCACCCAGCTCCCACCCCACCCACAGGGCCCTCACCTGCAGATTGTGATCGTGGCCGCACAGGTAGGCAGTGACCCCGTATGTGGCCAGCAGTGGCCGTAGCTGCTTGACCAGGCAGTGGGTAGGCCCGTGCTCGGCTATGGACCACACGGGGTAGTGGCCAGCCACCAGCACGTAGTCCTCCCTGGCCGCCGCCAGCTGTTTCTTGAGCCAGGACAGCTGTGTGCGGGCCAGCTTCACGTCTCGGGGCCTCTCAGGCTGCTGGCTGAGGAAGTCATCTGAGTTGCCACATAGTGTCACTGTGTCCAGCATAAAAATGGCCACAGACACATTGGTCTGTGGGATCTTGAAGTGCAGGCGGTAGAAAGGGCTGGGGAAGTTCCTGTGGAGGGGATAGAGGTCGTGGGTGCACATCTTGGGCGCAGAAGTCCCAGGGTCAGCTCAAGCCACAGGGCCCCTGTGTCCCTGCTATGTGAGGATCTCGGAAGGCAGGGCTGAGGGTGGCTCACCAGCGCTTGGAGATCTTAGAGTATGCAATCTGGGCAGAGACATTGCCAAGGTGGTCATGGTTTCCGGCTAGCACGTACCAGGGCACTTTGCGAAGGGAGCGGTCAGAGAATACGTCCTCAAAGGTCTCCTGTAGCAAACAGATAGGGCAGGCCTCTTCCCTGGGGTCAGTGGCTATGCCGATCCTCCCACCAAGTCAGGATAAGGGAGACACTGAATGCTCCCGGCGCCCAAAGGTGCCCCATCACCTTCCCTCTGCCCTCACCAAAGGAAGGTCACTAGGTAAGGCGGCTTCTCCCCACTGCCCGCCCCCACCTCCTGCCCCACTCTGTTGGGCACAGACCTGGAACCTCTTGTCATTGATGTCTTGCACACCAGTGAAGTAAAAATTGTCCCCTAGAGACAGGATGAAGTCTGCACCCAGGATCTGCACAGTCCGAGCGATCTCCTTGGCATTGGCCATTTCCCGGGCCGTGTGGAATGGGGCATTGGGGACCCCTCCCCAGTCACCCACGGCTACAAAGCGCAGGGCAGGGGTGGCACCATCAGCCAGGGAGGGTAGCAACAAGGCTTGCAGGATGAGCAGCGCCGTCCACATGTCCATCTGGGAGAAGAGAGACAAGCATAGGTGGCCCGGGCTGTGACAAGGGCAGGGAGGCCTTGAGACCCCCGCCTGCCCTGAGATAGAGGGAGACTGCTTGCTGCAGGCTGCCCCTGCGGGAACCCCTTGGTGCCCTAATTCTCAGGACACACAAGCTGCACAAGGCTGCACAAGCTGGCTTAGGGAAGGGGGGCGCGGTCTGTGAGAGGGCGAGCTGTACCAAGATGGCCCTGCAGGCCCATTTCACCCTCCTTCCACCTAGCCTGCCCAGCACTCACCCAGGGGGAGACACAGGCCAGTCACCGGAGGCTCTGAGAGGCTGGTGGGCTCTAGAGTAGAACTGCCGGTCCCTGAGCCTTTATTCCCTGAGGAGGAAGTGGATCATTAGTGAGGATGATGCAGTTTCTCCGAGGGCTGTCCCGGGAGCCCTCCCCTTGGGTCATGTGAGCCCTGGACTTCCCTGGAGCAGGACACGGGATTGGGGTGGGGGTGGGAGGATCTGGGCACACGTGTGCAGCAGCCTCGGCCCACACAGCCTCCGGGTGGACCTGCAGGGGCCTGTTTGTGCTGTAGGCTTGACACGTCCAGGTATCTCTGTGTGTCTGTGTATCTCAGTGTGAGTGTGTGTGTGTGTGCACACTTGAGAGGCTGTGGCTGTGATTACCCAAGACACATCTCCTGCACCTTCTTTCTCTGAGTAAGGGCTTACCTGTGTGTGTCTGGGTGTGTCTTGCTTCCTGCGTGCAGCTGAGCATGCCTACCTGGGCCTCGGCTCTGTACCTGATGGTGTTGCTGCAGACATGTATGCTGAGCCTGCGAGGCCTGTGTGGCTTGTCTGCGATGCACGCCTGTGTTCTCACGTGGCACTGGGTGGGAATCCCTATGGATGGAGTTTTGTGTGTGTCCATGTGTGTGTGCCTGGGTTGCATCTCTAGGATGGGTTGCGTGTCTGGTGTGGGAGCTGTGTTTGACAACATCTGGGTGGGGGACTCCGCGTGTGTCCCCGTCCTCCCCCTGCCCTCTCTCCATCCCACACATAAACACCAACGGGCTTCCCTTTTCCAGGAAGTCCTGCCCACACCCTCCCCTCCCCCCAGACTCCCATTCCTGCAGGAGGAACCAGGCAGGAGGCAGCTAGCTGGTGATAGCGCGCGTGACCACAGACCTCTGACCCTCATAGTCTCAGCAGCTGTCTGCAGGCCCTCCACGGGACCGCAGCCTGGGAGGGCAGGAGGCCCTGCACCTGCGGCCGGTCTGACCTGCTCCTCACCTCCCTGCCTGCCTCCTCCGTGCTGGGCGCCGCCGCGACACGTCCCGCGGACATTCAGGAGTCCCTTCAGTCCCTGCGAGCGCGGACCCGGGAGAGAGCTCTCATTCAACGCTGAGGCCACTGGCTCACAGATCTCCCCGGGTCACCCTGCGAAGTGCTTGGTCCCCCCCATTCCCAGCCCTGCAGCAGCAACAAACGGGAAGGAAGTGGGTGACGAGGACAGGCAGAGACCCCTCCCACGGGGCCGCCCGCATCTCACCTGCCGTCGCGGGGCGGGCGTTGCGGCCGGTGCCCAGCTGCAG
AACACTGTGGCTGGGACACATGTCCATGTGTGTTTCACATACGTGGGCATCTGTGCCACAAGGGTCATGTGGCACCACAGTTCATCAGCTGTGTTTCCCCTTCCTGCCCTGCTGCAGCGCCACAGGTTGGAGGAAAAGCCTGCCTGTGAGCAGGGTCCCGGCAGGGCCCACCCACCCAACAGTGGAGATCGGGCCTCAGAGCTGGGCAGTCATGGGAGTTCAGGGCCTGGCTCGCCTCGGCAGCCTGGTCTTAAAGAGGGACTTGCCCGAGGCCTCGATGTAAGTGACAGTCATCTCTTTGGAGCTGATCTCCACATAGGCAAAGCCACCCAGTGAGTCTTCAGTCCCATAGTGGAAGCGCAGATAGCCGTTGGGGACCTTGCGCTGGTGCCGCTTTGAGGGGTCCATGAAATTCCCAGCCCCACTCAGCACGTAGCCCACGCCATTCTCATCTTGCAGGTACTGAGGATGGAGGACAAGGGGTCAGTGGAGACCCAGCTTTGAGCAGAGCCCTGCCTAAGGTCCAGGGCTCGATCTGGCCCTAACCACAGAGTCACCTTGAGGTATGTAACCCCTCCTGGCTTCAATTTCCTGACTTTTAGGAGTGTATTAATCCTATTTCATAGGTAGAGCACTTAGTAAGAAATTGGTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGGGGTGGATTGCTTGAGCCCAGGAATTTGAGACCAGCCTGGGCAACATAGTGAGACCTTGCCTCTACAAAAAAAATGCGCAAGGGCCAGGTGCAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACTTGAGGTCAGAAGTTCGAGATCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAATATAAAAATTAGCAAGGTTTGGTGGCCCATGCTTGTAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGTTGAGATCGTGCCACTGCACTCCCTCTCAAAAAAAAAAAAAAAAGCAAAAATTAGCTGCATGTGGTGGCCCATGCCTGTAGTGTCAGCTACTCTGGAGGCTGAAGTGGGAGGTTCACCTGAGCCCGGGAGATTGAAGCTGCAGTAAGCCCCGATTGCACCACTGCACTCCAGCCTGGGTGAAAAACAATGAAACCTTGTCTCCAAAAAAAAAAAAAAAAAAGAGCTTAAAAAAGAAAGAAAGAAAGAAATTGGCAATTCGAAGATATTATTCTGGCTTTGGAGTGTTTTCCTGGTTAGACAGCAAGATTTGAGGGACAGTCTAGACATTCTGAAGGCCACAGGAGACCCTCAAACAGCAGGAGGACCCCAGCCATGTGGACATCAGCTGGGATGGGGACCCCCCTCACCCAGCTCCCACCCCACCCACAGGGCCCTCACCTGCAGATTGTGATCGTGGCCGCACAGGTAGGCAGTGACCCCGTATGTGGCCAGCAGTGGCCGTAGCTGCTTGACCAGGCAGTGGGTAGGCCCGTGCTCGGCTATGGACCACACGGGGTAGTGGCCAGCCACCAGCACGTAGTCCTCCCTGGCCGCCGCCAGCTGTTTCTTGAGCCAGGACAGCTGTGTGCGGGCCAGCTTCACGTCTCGGGGCCTCTCAGGCTGCTGGCTGAGGAAGTCATCTGAGTTGCCACATAGTGTCACTGTGTCCAGCATAAAAATGGCCACAGACACATTGGTCTGTGGGATCTTGAAGTGCAGGCGGTAGAAAGGGCTGGGGAAGTTCCTGTGGAGGGGATAGAGGTCGTGGGTGCACATCTTGGGCGCAGAAGTCCCAGGGTCAGCTCAAGCCACAGGGCCCCTGTGTCCCTGCTATGTGAGGATCTCGGAAGGCAGGGCTGAGGGTGGCTCACCAGCGCTTGGAGATCTTAGAGTATGCAATCTGGGCAGAGACATTGCCAAGGTGGTCATGGTTTCCGGCTAGCACGTACCAGGGCACTTTGCGAAGGGAGCGGTCAGAGAATACGTCCTCAAAGATCTCCTGTAGCAAACAGATAGGGCAGGCCTCTTCCCTGGGGTCAGTGGCTATGCCGATCCTCCCACCAAGTCAGGATAAGGGAGACACTGAATGCTCCCGGCGCCCAAAGGTGCCCCATCACCTTCCCTCTGCCCTCACCAAAGGAAGGTCACTAGGTAAGGCGGCTTCTCCCCACTGCCCGCCCCCACCTCCTGCCCCACTCTGTTGGGCACAGACCTGGAACCTCTTGTCATTGATGTCTTGCACACCAGTGAAGTAAAAATTGTCCCCTAGAGACAGGATGAAGTCTGCACCCAGGATCTGCACAGTCCGAGCGATCTCCTTGGCATTGGCCATTTCCCGGGCCGTGTGGAATGGGGCATTGGGGACCCCTCCCCAGTCACCCACGGCTACAAAGCGCAGGGCAGGGGTGGCACCATCAGCCAGGGAGGGTAGCAACAAGGCTTGCAGGATGAGCAGCGCCGTCCACATGTCCATCTGGGAGAAGAGAGACAAGCATAGGTGGCCCGGGCTGTGACAAGGGCAGGGAGGCCTTGAGACCCCCGCCTGCCCTGAGATAGAGGGAGACTGCTTGCTGCAGGCTGCCCCTGCGGGAACCCCTTGGTGCCCTAATTCTCAGGACACACAAGCTGCACAAGGCTGCACAAGCTGGCTTAGGGAAGGGGGGCGCGGTCTGTGAGAGGGCGAGCTGTACCAAGATGGCCCTGCAGGCCCATTTCACCCTCCTTCCACCTAGCCTGCCCAGCACTCACCCAGGGGGAGACACAGGCCAGTCACCGGAGGCTCTGAGAGGCTGGTGGGCTCTAGAGTAGAACTGCCGGTCCCTGAGCCTTTATTCCCTGAGGAGGAAGTGGATCATTAGTGAGGATGATGCAGTTTCTCCGAGGGCTGTCCCGGGAGCCCTCCCCTTGGGTCATGTGAGCCCTGGACTTCCCTGGAGCAGGACACGGGATTGGGGTGGGGGTGGGAGGATCTGGGCACACGTGTGCAGCAGCCTCGGCCCACACAGCCTCCGGGTGGACCTGCAGGGGCCTGTTTGTGCTGTAGGCTTGACACGTCCAGGTATCTCTGTGTGTCTGTGTATCTCAGTGTGAGTGTGTGTGTGTGTGCACACTTGAGAGGCTGTGGCTGTGATTACCCAAGACACATCTCCTGCACCTTCTTTCTCTGAGTAAGGGCTTACCTGTGTGTGTCTGGGTGTGTCTTGCTTCCTGCGTGCAGCTGAGCATGCCTACCTGGGCCTCGGCTCTGTACCTGATGGTGTTGCTGCAGACATGTATGCTGAGCCTGCGAGGCCTGTGTGGCTTGTCTGCGATGCACGCCTGTGTTCTCACGTGGCACTGGGTGGGAATCCCTATGGATGGAGTTTTGTGTGTGTCCATGTGTGTGTGCCTGGGTTGCATCTCTAGGATGGGTTGCGTGTCTGGTGTGGGAGCTGTGTTTGACAACATCTGGGTGGGGGACTCCGCGTGTGTCCCCGTCCTCCCCCTGCCCTCTCTCCATCCCACACATAAACACCAACGGGCTTCCCTTTTCCAGGAAGTCCTGCCCACACCCTCCCCTCCCCCCAGACTCCCATTCCTGCAGGAGGAACCAGGCAGGAGGCAGCTAGCTGGTGATAGCGCGCGTGACCACAGACCTCTGACCCTCATAGTCTCAGCAGCTGTCTGCAGGCCCTCCACGGGACCGCAGCCTGGGAGGGCAGGAGGCCCTGCACCTGCGGCCGGTCTGACCTGCTCCTCACCTCCCTGCCTGCCTCCTCCGTGCTGGGCGCCGCCGCGACACGTCCCGCGGACATTCAGGAGTCCCTTCAGTCCCTGCGAGCGCGGACCCGGGAGAGAGCTCTCATTCAACGCTGAGGCCACTGGCTCACAGATCTCCCCGGGTCACCCTGCGAAGTGCTTGGTCCCCCCCATTCCCAGCCCTGCAGCAGCAACAAACGGGAAGGAAGTGGGTGACGAGGACAGGCAGAGACCCCTCCCACGGGGCCGCCCGCATCTCACCTGCCGTCGCGGGGCGGGCGTTGCGGCCGGTGCCCAGCTGCAG
Task1_train_26553
A change on Chromosome 19 affects gene MAN2B1 (mannosidase alpha class 2B member 1). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Deficiency of alpha-mannosidase
CAGGACAGAGCCTGGGGGCGGTGAGAGGGCGGGGCTAAAGTGAAATGGGCGGGGCCGGAGGTGAGTTGGTGGTTTAGGGGCATGAGCTAGGGCTGTGCCTCTACACAGTCCAGGGGGGTTGGGACTGGGCTGGCACTGGGCGGGGACTGCCCAGGGGATGGGGTTGGCCCGAGGGTTTGGGGCTAATTATGGCCAAATGGATCCCCGCTGAGCCTAGGAAACTCCGCACCCAAACCCGGCTCCCTGGTAGACTTCAATCCGGTCCTCTCTGCCTACCCCGCTGCCCCTCACCTGCGTGCGCGGAGGAGCCCCGAGATTGTAGGCGGCGCCGCCACCCGGGGCCAGCACCACCTGAGGGGCCAGGACCTCCTGCTCCGCCAGGAGCCGGTGTCCGGCGGCTGCAGCCTGGGCTGTGTCCAGCAGCACCAGGTGGCGCCCTCGCACCCACGCCCCCGACCCGTTCTCCATTAGTGGCTCCGATACTCCGCGTCCATCGTCCTTCAGCAGCCTTCGGTGCACCTGGGGGGAGAGTGGCCAGGAGGGGGTGAGAGTCGTGGGTTTGTGGGTGTCCTTGGGCCAGAAACTGGGTAAGGGCGTGTGGGAATGTCAAAAGAAATTAAAGGGTGGGAGGAACGGATGAGGATGAAGGTGAGGGTCTGGTAGGGCAACCCCAGCAGAGGCAGGATCCAAGTAGGCATGGGAACCAGGCCGGAAGGAGGTAAATGCCTAACAGGGGGGCCTGGATATGGCACGCCAGAGCGTGGAGGGAGCCTGGGCAGGAGATGGAGAAAAACGGAGAGGAAAAGCCACACACAGAAATGGAGTCCTTGGCCGGGAGCGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGAGTGGATCACCTGAGGTAAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACCAAAATTAGCCGGGCGTGATGGTGTGTGCCTGTAAGCCCAGCTACTCGGAAGGCTGAGGCAGGACAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATAGTACTATTGCACTCCAGCTTGGACAACAAGAGCAAAACTCCGTCTCAAAGAGAAGAAAAGAAAGAAACGGAGTCCTCAGCTTAGTGGGGCCTGAAAGCAGAGAACTGGGCCAGAAACAGCCTTCAAGGTCCAGCAGGGGTCCAGGTTGGGAGGACCCTGGCTCGGATGGGGCTCTGACCCACTCACCATGAGCTCCAGCGAGCCATCTCTCAGGCTGCTGCCCCCCTGGGAGCGGTCAGTCAGCACAGTCAGCTGCATGTTTCCATCCTGGGAGTTGAAGGGTGAAAGTAGAGGGCAGTCAACCCCAACCCCAGGCAGCTTTGAGATGCTGCAGATAAGGGGTGATTCCCTTTCTATCGAGGTGGGGAGGTGCAGGATGGGGGAGAGCTACCGTGATGTAAATCCGGGTGTTGACTGGATAGTAGTTTCCTGCCACGGGCTCCGTCTGGTTCAGTTTCCAGGTGGGTCGATAATCCCGCCTGGGGTTGGGGGTGAGCTGATCAGGCTTGGGATCTGGCTCCCCAACTCTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGCTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTGATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATAGTCTCGATCTCCTGACCTTGTGATCTGCCCGCCTCGGCTTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCTGCCTGGCTCCCCCGCCCTTCACTCTCCCTTCGTCCTCTGTCTCCCACACTCATGTAATCAGCAAATTTCCCTCACCACCCCTGGGCCCCAACACACCACAGACCACCCCCTCAGTGCTCTCAGTCACCCCCCACCTCCTCTCCAGGATCTCCCGGCCATTGCTGTCTGTGTAGAAGCGTCCCTTTGTCTCCAGCGGTGTGTCAAAACGGCTGATGACCTCCTTCCCCCAGGTGTCGCTGTACCCAATGGGATGGCAAGGTTGTGAGCCTTGGATAAACCCCTCTGCCCTTGCTTCCACACCCCTCTCCCAGCCTGTGCCACTCACCCCACAGGTATCGGCCCCACCGACCACTCTAGCTCCAGGTGCCGCTGTCCTGGGTACAGGCGAACCACCTGGGAACACCAAGCTGAGAAGTTCTGGTGCACCTCCTGCACCAAGGGTGTCTGCGGGCACACGGGTGAGGTGGATGTCAGTCTGTACCTGAGCAGAGGTGAGTCCTACAAATGTCCCCCAACCCTGGCCATAAACCCCATTAAGGCCTACATCAAGGTCAACCTTCAGTCACCGCCACATAATTCTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTTTTGCCCAGGCGGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCAAGGATGGTCTCGATCTCCTGACCTCGTGATCAGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCCACATAATTCTTTTTTCTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTTGTTGCCCAGGATGGAGTGCAGTGGCACAATCTTGCCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGAGGGATTGCAGGTACCTGCCACCACCCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCTATCCATGTTGGCCAGACTTGTCTTGAACTCCTGACCTCAGATGATCTGCCTGCCTCTGCCTCGCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCGGCCTCTTTTTTTTTTTTTTTTTTTGAGACAGGGCATCACTATGTAGGCACCTAATCAGCAAATGCTCCCACCTGGTCTTGAACTCCTATGCTCAGCGATCCTCCTGCTTCAGTCTCCCAAAGTGCTGTGATTACAGGCATGAGCCACTGCATCTGGCTTACCACATCACTCTTGAGCGTGGCATAAACGCCTCCTGTTCACCATTGCCCCATAGAATAGGATTCTAGCTTGGCACATGGCTACCTGGGATAAAGACTATATTGTCCAGTCTTCCCTGAGGCTATCAGTAGCTGAGTGACCAGTTTGCCCCATAGAAAGTGATCCAAGTGGTGTCAACAATGTTCCTTGCCCCTGTCCCTCTGCTACTGACTCAAACACAAATGTGGCGGCTGGAGCTTCAGCAGCTATCTTGGACCATGAGGTGGAAACTGAATATTGGGGAAGGCAGAGCAACAAGATAGAAGAGGAGGTCCTGGGTGATTATGGAACCACCCCACTTTCTCTGGACTAACAGCCAGACTTTTTGTTAGAAGAAAATAATCTTCTATCTTATTCTAGTCACAGTTAATTTGGGTAACTCTGTTAGAACAGGCAAAACTATATACAGATATGCAGACATTCATCTCAAAGGGACTCACATGAAACGCGAGGCTCTTGAATGTGGACAAATGTGAGTTTTGTCATCTATGAAAGTCAAACATCAATGAGAGGCCCTGGGAAACCACTGTTCCTAGCCAGATGCACCCATAGGCATTCACCCTGAGACTCACCCAAACCCAATCAATCCAAGGGTGGACTCTCAAATATTCACTCCAGATAGAAGCTCCTCTTACTACAGACTTTGGTGAATTCTTCAAGCAGTGATATTTGGCTCTCCTGATTCATGGGCCAAGTGGGAATGCCCCACCCCCAATTTCCAAAACTAAGTATGTAAACGTCCACAGCAGATGTGAATGGCTTTGTATGATGTGTCCTATGGGGAGACTCTCATACGACCAGCTATGAATATCA
CAGGACAGAGCCTGGGGGCGGTGAGAGGGCGGGGCTAAAGTGAAATGGGCGGGGCCGGAGGTGAGTTGGTGGTTTAGGGGCATGAGCTAGGGCTGTGCCTCTACACAGTCCAGGGGGGTTGGGACTGGGCTGGCACTGGGCGGGGACTGCCCAGGGGATGGGGTTGGCCCGAGGGTTTGGGGCTAATTATGGCCAAATGGATCCCCGCTGAGCCTAGGAAACTCCGCACCCAAACCCGGCTCCCTGGTAGACTTCAATCCGGTCCTCTCTGCCTACCCCGCTGCCCCTCACCTGCGTGCGCGGAGGAGCCCCGAGATTGTAGGCGGCGCCGCCACCCGGGGCCAGCACCACCTGAGGGGCCAGGACCTCCTGCTCCGCCAGGAGCCGGTGTCCGGCGGCTGCAGCCTGGGCTGTGTCCAGCAGCACCAGGTGGCGCCCTCGCACCCACGCCCCCGACCCGTTCTCCATTAGTGGCTCCGATACTCCGCGTCCATCGTCCTTCAGCAGCCTTCGGTGCACCTGGGGGGAGAGTGGCCAGGAGGGGGTGAGAGTCGTGGGTTTGTGGGTGTCCTTGGGCCAGAAACTGGGTAAGGGCGTGTGGGAATGTCAAAAGAAATTAAAGGGTGGGAGGAACGGATGAGGATGAAGGTGAGGGTCTGGTAGGGCAACCCCAGCAGAGGCAGGATCCAAGTAGGCATGGGAACCAGGCCGGAAGGAGGTAAATGCCTAACAGGGGGGCCTGGATATGGCACGCCAGAGCGTGGAGGGAGCCTGGGCAGGAGATGGAGAAAAACGGAGAGGAAAAGCCACACACAGAAATGGAGTCCTTGGCCGGGAGCGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGAGTGGATCACCTGAGGTAAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACCAAAATTAGCCGGGCGTGATGGTGTGTGCCTGTAAGCCCAGCTACTCGGAAGGCTGAGGCAGGACAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATAGTACTATTGCACTCCAGCTTGGACAACAAGAGCAAAACTCCGTCTCAAAGAGAAGAAAAGAAAGAAACGGAGTCCTCAGCTTAGTGGGGCCTGAAAGCAGAGAACTGGGCCAGAAACAGCCTTCAAGGTCCAGCAGGGGTCCAGGTTGGGAGGACCCTGGCTCGGATGGGGCTCTGACCCACTCACCATGAGCTCCAGCGAGCCATCTCTCAGGCTGCTGCCCCCCTGGGAGCGGTCAGTCAGCACAGTCAGCTGCATGTTTCCATCCTGGGAGTTGAAGGGTGAAAGTAGAGGGCAGTCAACCCCAACCCCAGGCAGCTTTGAGATGCTGCAGATAAGGGGTGATTCCCTTTCTATCGAGGTGGGGAGGTGCAGGATGGGGGAGAGCTACCGTGATGTAAATCCGGGTGTTGACTGGATAGTAGTTTCCTGCCACGGGCTCCGTCTGGTTCAGTTTCCAGGTGGGTCGATAATCCCGCCTGGGGTTGGGGGTGAGCTGATCAGGCTTGGGATCTGGCTCCCCAACTCTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGCTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTGATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATAGTCTCGATCTCCTGACCTTGTGATCTGCCCGCCTCGGCTTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCTGCCTGGCTCCCCCGCCCTTCACTCTCCCTTCGTCCTCTGTCTCCCACACTCATGTAATCAGCAAATTTCCCTCACCACCCCTGGGCCCCAACACACCACAGACCACCCCCTCAGTGCTCTCAGTCACCCCCCACCTCCTCTCCAGGATCTCCCAGCCATTGCTGTCTGTGTAGAAGCGTCCCTTTGTCTCCAGCGGTGTGTCAAAACGGCTGATGACCTCCTTCCCCCAGGTGTCGCTGTACCCAATGGGATGGCAAGGTTGTGAGCCTTGGATAAACCCCTCTGCCCTTGCTTCCACACCCCTCTCCCAGCCTGTGCCACTCACCCCACAGGTATCGGCCCCACCGACCACTCTAGCTCCAGGTGCCGCTGTCCTGGGTACAGGCGAACCACCTGGGAACACCAAGCTGAGAAGTTCTGGTGCACCTCCTGCACCAAGGGTGTCTGCGGGCACACGGGTGAGGTGGATGTCAGTCTGTACCTGAGCAGAGGTGAGTCCTACAAATGTCCCCCAACCCTGGCCATAAACCCCATTAAGGCCTACATCAAGGTCAACCTTCAGTCACCGCCACATAATTCTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTTTTGCCCAGGCGGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCAAGGATGGTCTCGATCTCCTGACCTCGTGATCAGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCCACATAATTCTTTTTTCTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTTGTTGCCCAGGATGGAGTGCAGTGGCACAATCTTGCCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGAGGGATTGCAGGTACCTGCCACCACCCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCTATCCATGTTGGCCAGACTTGTCTTGAACTCCTGACCTCAGATGATCTGCCTGCCTCTGCCTCGCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCGGCCTCTTTTTTTTTTTTTTTTTTTGAGACAGGGCATCACTATGTAGGCACCTAATCAGCAAATGCTCCCACCTGGTCTTGAACTCCTATGCTCAGCGATCCTCCTGCTTCAGTCTCCCAAAGTGCTGTGATTACAGGCATGAGCCACTGCATCTGGCTTACCACATCACTCTTGAGCGTGGCATAAACGCCTCCTGTTCACCATTGCCCCATAGAATAGGATTCTAGCTTGGCACATGGCTACCTGGGATAAAGACTATATTGTCCAGTCTTCCCTGAGGCTATCAGTAGCTGAGTGACCAGTTTGCCCCATAGAAAGTGATCCAAGTGGTGTCAACAATGTTCCTTGCCCCTGTCCCTCTGCTACTGACTCAAACACAAATGTGGCGGCTGGAGCTTCAGCAGCTATCTTGGACCATGAGGTGGAAACTGAATATTGGGGAAGGCAGAGCAACAAGATAGAAGAGGAGGTCCTGGGTGATTATGGAACCACCCCACTTTCTCTGGACTAACAGCCAGACTTTTTGTTAGAAGAAAATAATCTTCTATCTTATTCTAGTCACAGTTAATTTGGGTAACTCTGTTAGAACAGGCAAAACTATATACAGATATGCAGACATTCATCTCAAAGGGACTCACATGAAACGCGAGGCTCTTGAATGTGGACAAATGTGAGTTTTGTCATCTATGAAAGTCAAACATCAATGAGAGGCCCTGGGAAACCACTGTTCCTAGCCAGATGCACCCATAGGCATTCACCCTGAGACTCACCCAAACCCAATCAATCCAAGGGTGGACTCTCAAATATTCACTCCAGATAGAAGCTCCTCTTACTACAGACTTTGGTGAATTCTTCAAGCAGTGATATTTGGCTCTCCTGATTCATGGGCCAAGTGGGAATGCCCCACCCCCAATTTCCAAAACTAAGTATGTAAACGTCCACAGCAGATGTGAATGGCTTTGTATGATGTGTCCTATGGGGAGACTCTCATACGACCAGCTATGAATATCA
Task1_train_26554
Consider this mutation in MAN2B1 (mannosidase alpha class 2B member 1) on Chromosome 19. Is this a benign change or a disease-causing variant?
Pathogenic; Inborn genetic diseases
CAGGACAGAGCCTGGGGGCGGTGAGAGGGCGGGGCTAAAGTGAAATGGGCGGGGCCGGAGGTGAGTTGGTGGTTTAGGGGCATGAGCTAGGGCTGTGCCTCTACACAGTCCAGGGGGGTTGGGACTGGGCTGGCACTGGGCGGGGACTGCCCAGGGGATGGGGTTGGCCCGAGGGTTTGGGGCTAATTATGGCCAAATGGATCCCCGCTGAGCCTAGGAAACTCCGCACCCAAACCCGGCTCCCTGGTAGACTTCAATCCGGTCCTCTCTGCCTACCCCGCTGCCCCTCACCTGCGTGCGCGGAGGAGCCCCGAGATTGTAGGCGGCGCCGCCACCCGGGGCCAGCACCACCTGAGGGGCCAGGACCTCCTGCTCCGCCAGGAGCCGGTGTCCGGCGGCTGCAGCCTGGGCTGTGTCCAGCAGCACCAGGTGGCGCCCTCGCACCCACGCCCCCGACCCGTTCTCCATTAGTGGCTCCGATACTCCGCGTCCATCGTCCTTCAGCAGCCTTCGGTGCACCTGGGGGGAGAGTGGCCAGGAGGGGGTGAGAGTCGTGGGTTTGTGGGTGTCCTTGGGCCAGAAACTGGGTAAGGGCGTGTGGGAATGTCAAAAGAAATTAAAGGGTGGGAGGAACGGATGAGGATGAAGGTGAGGGTCTGGTAGGGCAACCCCAGCAGAGGCAGGATCCAAGTAGGCATGGGAACCAGGCCGGAAGGAGGTAAATGCCTAACAGGGGGGCCTGGATATGGCACGCCAGAGCGTGGAGGGAGCCTGGGCAGGAGATGGAGAAAAACGGAGAGGAAAAGCCACACACAGAAATGGAGTCCTTGGCCGGGAGCGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGAGTGGATCACCTGAGGTAAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACCAAAATTAGCCGGGCGTGATGGTGTGTGCCTGTAAGCCCAGCTACTCGGAAGGCTGAGGCAGGACAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATAGTACTATTGCACTCCAGCTTGGACAACAAGAGCAAAACTCCGTCTCAAAGAGAAGAAAAGAAAGAAACGGAGTCCTCAGCTTAGTGGGGCCTGAAAGCAGAGAACTGGGCCAGAAACAGCCTTCAAGGTCCAGCAGGGGTCCAGGTTGGGAGGACCCTGGCTCGGATGGGGCTCTGACCCACTCACCATGAGCTCCAGCGAGCCATCTCTCAGGCTGCTGCCCCCCTGGGAGCGGTCAGTCAGCACAGTCAGCTGCATGTTTCCATCCTGGGAGTTGAAGGGTGAAAGTAGAGGGCAGTCAACCCCAACCCCAGGCAGCTTTGAGATGCTGCAGATAAGGGGTGATTCCCTTTCTATCGAGGTGGGGAGGTGCAGGATGGGGGAGAGCTACCGTGATGTAAATCCGGGTGTTGACTGGATAGTAGTTTCCTGCCACGGGCTCCGTCTGGTTCAGTTTCCAGGTGGGTCGATAATCCCGCCTGGGGTTGGGGGTGAGCTGATCAGGCTTGGGATCTGGCTCCCCAACTCTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGCTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTGATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATAGTCTCGATCTCCTGACCTTGTGATCTGCCCGCCTCGGCTTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCTGCCTGGCTCCCCCGCCCTTCACTCTCCCTTCGTCCTCTGTCTCCCACACTCATGTAATCAGCAAATTTCCCTCACCACCCCTGGGCCCCAACACACCACAGACCACCCCCTCAGTGCTCTCAGTCACCCCCCACCTCCTCTCCAGGATCTCCCGGCCATTGCTGTCTGTGTAGAAGCGTCCCTTTGTCTCCAGCGGTGTGTCAAAACGGCTGATGACCTCCTTCCCCCAGGTGTCGCTGTACCCAATGGGATGGCAAGGTTGTGAGCCTTGGATAAACCCCTCTGCCCTTGCTTCCACACCCCTCTCCCAGCCTGTGCCACTCACCCCACAGGTATCGGCCCCACCGACCACTCTAGCTCCAGGTGCCGCTGTCCTGGGTACAGGCGAACCACCTGGGAACACCAAGCTGAGAAGTTCTGGTGCACCTCCTGCACCAAGGGTGTCTGCGGGCACACGGGTGAGGTGGATGTCAGTCTGTACCTGAGCAGAGGTGAGTCCTACAAATGTCCCCCAACCCTGGCCATAAACCCCATTAAGGCCTACATCAAGGTCAACCTTCAGTCACCGCCACATAATTCTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTTTTGCCCAGGCGGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCAAGGATGGTCTCGATCTCCTGACCTCGTGATCAGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCCACATAATTCTTTTTTCTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTTGTTGCCCAGGATGGAGTGCAGTGGCACAATCTTGCCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGAGGGATTGCAGGTACCTGCCACCACCCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCTATCCATGTTGGCCAGACTTGTCTTGAACTCCTGACCTCAGATGATCTGCCTGCCTCTGCCTCGCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCGGCCTCTTTTTTTTTTTTTTTTTTTGAGACAGGGCATCACTATGTAGGCACCTAATCAGCAAATGCTCCCACCTGGTCTTGAACTCCTATGCTCAGCGATCCTCCTGCTTCAGTCTCCCAAAGTGCTGTGATTACAGGCATGAGCCACTGCATCTGGCTTACCACATCACTCTTGAGCGTGGCATAAACGCCTCCTGTTCACCATTGCCCCATAGAATAGGATTCTAGCTTGGCACATGGCTACCTGGGATAAAGACTATATTGTCCAGTCTTCCCTGAGGCTATCAGTAGCTGAGTGACCAGTTTGCCCCATAGAAAGTGATCCAAGTGGTGTCAACAATGTTCCTTGCCCCTGTCCCTCTGCTACTGACTCAAACACAAATGTGGCGGCTGGAGCTTCAGCAGCTATCTTGGACCATGAGGTGGAAACTGAATATTGGGGAAGGCAGAGCAACAAGATAGAAGAGGAGGTCCTGGGTGATTATGGAACCACCCCACTTTCTCTGGACTAACAGCCAGACTTTTTGTTAGAAGAAAATAATCTTCTATCTTATTCTAGTCACAGTTAATTTGGGTAACTCTGTTAGAACAGGCAAAACTATATACAGATATGCAGACATTCATCTCAAAGGGACTCACATGAAACGCGAGGCTCTTGAATGTGGACAAATGTGAGTTTTGTCATCTATGAAAGTCAAACATCAATGAGAGGCCCTGGGAAACCACTGTTCCTAGCCAGATGCACCCATAGGCATTCACCCTGAGACTCACCCAAACCCAATCAATCCAAGGGTGGACTCTCAAATATTCACTCCAGATAGAAGCTCCTCTTACTACAGACTTTGGTGAATTCTTCAAGCAGTGATATTTGGCTCTCCTGATTCATGGGCCAAGTGGGAATGCCCCACCCCCAATTTCCAAAACTAAGTATGTAAACGTCCACAGCAGATGTGAATGGCTTTGTATGATGTGTCCTATGGGGAGACTCTCATACGACCAGCTATGAATATCA
CAGGACAGAGCCTGGGGGCGGTGAGAGGGCGGGGCTAAAGTGAAATGGGCGGGGCCGGAGGTGAGTTGGTGGTTTAGGGGCATGAGCTAGGGCTGTGCCTCTACACAGTCCAGGGGGGTTGGGACTGGGCTGGCACTGGGCGGGGACTGCCCAGGGGATGGGGTTGGCCCGAGGGTTTGGGGCTAATTATGGCCAAATGGATCCCCGCTGAGCCTAGGAAACTCCGCACCCAAACCCGGCTCCCTGGTAGACTTCAATCCGGTCCTCTCTGCCTACCCCGCTGCCCCTCACCTGCGTGCGCGGAGGAGCCCCGAGATTGTAGGCGGCGCCGCCACCCGGGGCCAGCACCACCTGAGGGGCCAGGACCTCCTGCTCCGCCAGGAGCCGGTGTCCGGCGGCTGCAGCCTGGGCTGTGTCCAGCAGCACCAGGTGGCGCCCTCGCACCCACGCCCCCGACCCGTTCTCCATTAGTGGCTCCGATACTCCGCGTCCATCGTCCTTCAGCAGCCTTCGGTGCACCTGGGGGGAGAGTGGCCAGGAGGGGGTGAGAGTCGTGGGTTTGTGGGTGTCCTTGGGCCAGAAACTGGGTAAGGGCGTGTGGGAATGTCAAAAGAAATTAAAGGGTGGGAGGAACGGATGAGGATGAAGGTGAGGGTCTGGTAGGGCAACCCCAGCAGAGGCAGGATCCAAGTAGGCATGGGAACCAGGCCGGAAGGAGGTAAATGCCTAACAGGGGGGCCTGGATATGGCACGCCAGAGCGTGGAGGGAGCCTGGGCAGGAGATGGAGAAAAACGGAGAGGAAAAGCCACACACAGAAATGGAGTCCTTGGCCGGGAGCGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGAGTGGATCACCTGAGGTAAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACCAAAATTAGCCGGGCGTGATGGTGTGTGCCTGTAAGCCCAGCTACTCGGAAGGCTGAGGCAGGACAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATAGTACTATTGCACTCCAGCTTGGACAACAAGAGCAAAACTCCGTCTCAAAGAGAAGAAAAGAAAGAAACGGAGTCCTCAGCTTAGTGGGGCCTGAAAGCAGAGAACTGGGCCAGAAACAGCCTTCAAGGTCCAGCAGGGGTCCAGGTTGGGAGGACCCTGGCTCGGATGGGGCTCTGACCCACTCACCATGAGCTCCAGCGAGCCATCTCTCAGGCTGCTGCCCCCCTGGGAGCGGTCAGTCAGCACAGTCAGCTGCATGTTTCCATCCTGGGAGTTGAAGGGTGAAAGTAGAGGGCAGTCAACCCCAACCCCAGGCAGCTTTGAGATGCTGCAGATAAGGGGTGATTCCCTTTCTATCGAGGTGGGGAGGTGCAGGATGGGGGAGAGCTACCGTGATGTAAATCCGGGTGTTGACTGGATAGTAGTTTCCTGCCACGGGCTCCGTCTGGTTCAGTTTCCAGGTGGGTCGATAATCCCGCCTGGGGTTGGGGGTGAGCTGATCAGGCTTGGGATCTGGCTCCCCAACTCTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGCTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTGATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATAGTCTCGATCTCCTGACCTTGTGATCTGCCCGCCTCGGCTTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCTGCCTGGCTCCCCCGCCCTTCACTCTCCCTTCGTCCTCTGTCTCCCACACTCATGTAATCAGCAAATTTCCCTCACCACCCCTGGGCCCCAACACACCACAGACCACCCCCTCAGTGCTCTCAGTCACCCCCCACCTCCTCTCCAGGATCTCCCAGCCATTGCTGTCTGTGTAGAAGCGTCCCTTTGTCTCCAGCGGTGTGTCAAAACGGCTGATGACCTCCTTCCCCCAGGTGTCGCTGTACCCAATGGGATGGCAAGGTTGTGAGCCTTGGATAAACCCCTCTGCCCTTGCTTCCACACCCCTCTCCCAGCCTGTGCCACTCACCCCACAGGTATCGGCCCCACCGACCACTCTAGCTCCAGGTGCCGCTGTCCTGGGTACAGGCGAACCACCTGGGAACACCAAGCTGAGAAGTTCTGGTGCACCTCCTGCACCAAGGGTGTCTGCGGGCACACGGGTGAGGTGGATGTCAGTCTGTACCTGAGCAGAGGTGAGTCCTACAAATGTCCCCCAACCCTGGCCATAAACCCCATTAAGGCCTACATCAAGGTCAACCTTCAGTCACCGCCACATAATTCTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTTTTGCCCAGGCGGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCAAGGATGGTCTCGATCTCCTGACCTCGTGATCAGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCCACATAATTCTTTTTTCTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTTGTTGCCCAGGATGGAGTGCAGTGGCACAATCTTGCCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGAGGGATTGCAGGTACCTGCCACCACCCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCTATCCATGTTGGCCAGACTTGTCTTGAACTCCTGACCTCAGATGATCTGCCTGCCTCTGCCTCGCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCGGCCTCTTTTTTTTTTTTTTTTTTTGAGACAGGGCATCACTATGTAGGCACCTAATCAGCAAATGCTCCCACCTGGTCTTGAACTCCTATGCTCAGCGATCCTCCTGCTTCAGTCTCCCAAAGTGCTGTGATTACAGGCATGAGCCACTGCATCTGGCTTACCACATCACTCTTGAGCGTGGCATAAACGCCTCCTGTTCACCATTGCCCCATAGAATAGGATTCTAGCTTGGCACATGGCTACCTGGGATAAAGACTATATTGTCCAGTCTTCCCTGAGGCTATCAGTAGCTGAGTGACCAGTTTGCCCCATAGAAAGTGATCCAAGTGGTGTCAACAATGTTCCTTGCCCCTGTCCCTCTGCTACTGACTCAAACACAAATGTGGCGGCTGGAGCTTCAGCAGCTATCTTGGACCATGAGGTGGAAACTGAATATTGGGGAAGGCAGAGCAACAAGATAGAAGAGGAGGTCCTGGGTGATTATGGAACCACCCCACTTTCTCTGGACTAACAGCCAGACTTTTTGTTAGAAGAAAATAATCTTCTATCTTATTCTAGTCACAGTTAATTTGGGTAACTCTGTTAGAACAGGCAAAACTATATACAGATATGCAGACATTCATCTCAAAGGGACTCACATGAAACGCGAGGCTCTTGAATGTGGACAAATGTGAGTTTTGTCATCTATGAAAGTCAAACATCAATGAGAGGCCCTGGGAAACCACTGTTCCTAGCCAGATGCACCCATAGGCATTCACCCTGAGACTCACCCAAACCCAATCAATCCAAGGGTGGACTCTCAAATATTCACTCCAGATAGAAGCTCCTCTTACTACAGACTTTGGTGAATTCTTCAAGCAGTGATATTTGGCTCTCCTGATTCATGGGCCAAGTGGGAATGCCCCACCCCCAATTTCCAAAACTAAGTATGTAAACGTCCACAGCAGATGTGAATGGCTTTGTATGATGTGTCCTATGGGGAGACTCTCATACGACCAGCTATGAATATCA
Task1_train_26555
This variant affects gene LOC129391064, MAN2B1 (MPRA-validated peak3365 silencer| mannosidase alpha class 2B member 1) located on Chromosome 19. Evaluate its biological effect and specify any disease association.
Pathogenic; Deficiency of alpha-mannosidase
CTGACATGTCTGTCAAGTGTCACCCATGATCACACTGGGTCCTCATAACAGTCCCAGGAAAGGACACTGAGGCTCAGACAAAGGTCACTTGCTCAAGGACACACAATGAGGGGAGTTGTGACAGGAGGTCATAAGCCTAGGGACCTGCTGACCCAGAGTCCACACAGCTCACCATGACACTTCAAATTTGTCACAGGAGCAGGAAAGGGGATTGAAATGGGGTCTCACCTCATTTTCGATGGTTAAAGCAGGGGACCAGGATCTTCTGGGGATGGGCTGTGGTGCGCGGGCCTGGGGCTTCCAGCGAGGCACCTGGGCTACTGAATAGGTGCTGAAGCCCAGGGCGGGCAGTGAGGCTGAGAACAGCAGCTCCGGAGGGTGCGCCTGGCTGTCTGAGCTGGGAAATATTACCACCTCGGATAAAGGAGGAGGGAAACTGAGTCAAGAGTACCCATGGAAAGCTATACATGCATGGAGACAAAAAACTCAAGGAAGGAAAAGAGTCCTGAGATGGGGAAAGGAAATGGAGGTGTGTGTGGTGGGGGGACAGTCAGATTCCAAGGAAATGATTGCAGAGAAGATTCACCAGGTGGAAAAAAAAACCCACCGGGAGGGTGGAGAGACCATGGAGTCGGGGGAGTGAAGGAGGAAGTAGGGGAAGAAACCCTTGAGGCAGGTTCTCGGGGGAGGAAGAGGTTTGGGGGAGGACGTTTTCTGGAATGAAGGAGATGTCCATAAACAGCAATAAATTTTCCTGGGGAAGCGGGGTATTAAAATGGAGGACCAGCCAGGCACGGTGGCTCATGCCTATAATCCAGCAGGCGGAGTTTGAAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAGGGAGGACCACTCACAGGAGGCATATGTTCCCAAGGGGAGACTGATATTAAGGGGCAGAGGGAGAAGATACAAGAGGGGGGAAGAGATATGCATGAGTGGGAGGTATTCATGGAAGCAGGCGATATCCATGGGGGCGATGAGGAAATGCCCACTGGGGGAGGAGTCCCAGCGGGGGAATATTCGTTGTTTGGGCTCACATCGCTGGGCACTGTCCTGCCATTGGGGTCCTTCACAACGAAAACGCCTTCGCTGACCGGCAGCCGTACCATCCAATTCACCTTCCGCCCCAGGGGATTATAAACGATGACCTGGAACTGGGGAGGCGGGGGTCAGAGAGGGCATGGGTCACAGCAGGCCTTCTCCAAACCCACCCACTTTGCACAGAAACACCCCTGGCTGGTCCTAGTGTGGTCACGGCACTTAAGGCCAAGCCCCCTCGAGATGCGTTGTTCTCTCTGCTGACCCAGCTTCGCAGCCCACGTAATTTCACTCCTGTATAGTCCTCCAAAAACATTTTCCAACTACCCCCTCTAAAGCCCATCTGCCCTAGATCCACCCCTCCCGTCCCGGCTCACGCGCGCCGCCGTCTGGCTGAGCGGGCAGATGCTGATGTTTAGCTGTTGGCAAAAGGTGAAGTGATCTTTGAAGCCTCTGAGCCGCGCCAGCGCGTTGCTCAGAAGAACCTGCGGAAGAGCGCAAAGGGACCGGTGGGTTCAGGACGCCAGGCCTGACTCCTCCCCTCTCCTCAGGCCCCGCCCCGTTCCGGTCTCTGTCCCGCCTCCCTCAAGAGTCGCCCCAAAACCCCTTCTAGCCCCACCCTGCTGCCCTTGACTATACCCCATAGCTGTCTCCGCCTCCTCTTGCCCACGCCCCGCCTCCTTCCCCCCTCCAAAGCCCCGCCCCGTTCCTGTATCTTTCCCCGCCTCCTACAAGCCCCGCCCCCACGAGCCCTTGTAGCCCCGCCACAGGGCTCTCGGCTACGCCTCACACCTGTCTCTGTCCCCTTTCCCAGGCCCTGGCCCCGCCCCTTCCTGTCTCCACCCCCGTGTCTCCCAAGTCTCGCCCCGCGCACCTCGCAAGGCCCCCAGCCTGCCGCAAGCTGGCGCGCGTAGTCGTTGGCCACGTGCTGGCGGGAGGTGCCGCTGACGGCGTCGTGATGCTGGAGCACAGCCATCGCCTCATCTGCTCATAGACAATGAGTCCGGTGAGGTTCTGTGGGACTCAGCTGAGACCCCAAGGGGAAGCGAAAGGTCCGGTGCTGGCGGGCAGGATTCTTAGAGGCTTTAAGAAGGAACTCGAGGACGGCTGGGGGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGACCGAGGCGGGCGGATCACGAGGTCAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGTCAGGAGAATGGCGTGAACACGGGAGGTGGAGCTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGAGACAAATCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAGAAGAAACTCGAGGGGGGCGGCCTAGGGGTGGTTTCCAACTTCAGCCGCAAACCTCTTCCCCTCTTGGGCCCGACACTTACTGAGGGGTGCACTGTCTCCGGAGCCATAGGGTCCCACGTTGGCCGCCAGGCCCACCAGCGCCTCCAGCTGGTTGCACACCTGGAGGCAGAGGGGTATGTTGGGGCGCCCAGCCTGTCGGGCCTCGGGGCTGCATGCCCCCTCTAGCCCGGCTCCTACCCACCTGCAGGAAGTTGTAGCTGAGGCGCTCGTAGCGTTTGAGGGCCGGCCGACTGGAAAAGTAACCGGTCCAGAACTGGTGGGGGCCATCCGCGTAAGGGAAGAAGTCGTCATGTTTCACTGACCTACAGCGGCAGGGGCATTGAGGGCAGGGTCATGACCCACGGGGCATGCCAACCCCCCCAAGCTCCCCAGTTTCCCCAAATACCAGGTGAGGTTGGCCTTGTTCAGCTCCCAGAGGTAACAAGCGGGGGTGGAGTAGAGAACATGGACACTGCTTCCTTTTGCCTGCTGCTGGGGGAGGCGACGGAGTGAGCCCTCGGGAGTCCGCACCTTCCTGGGGGCCCACACTTCCACACATGTGTGCACATTCATGCATCCCATAGGTTCAGTTTCTCTAAATACATATTTGGCGTGCAAGCCAATGGTTGGGTGTGAAAATGAATTTTGGCTGAAGTCAAACATGACCACTAGCCTTTTTTAAAAGGATTTCAGAGATGCAAGAATAAACCTGAAATTTTACTAAACTTTTACAATAATTCCAACTTTATTATTAAAAACTTTTGTGGAAAAACTAAGTGTGACATTATAGGGCAGGAATAATCGTTTTGCAGGACTGTCAGATTGTTACCAAAAAACACAACTTTTTTTTTTTGGGACGGAGTCTTACTTTGTTGCCCAGGCTGTAGTGCAGTGGCTCAATCTCAGCTCACTGCAAGCTCCACCTCTTGGGTTCACGCCATTCTCCAGCCTCAGCCTCATGAGTACCTGGGACTACAGGTGCCCGCCACCACACCCGGCTAATTTTTTGCATTTTTTAGTAGAGACGGAGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTGCCCGGCCTAGACACAATTTTTATAATGAATGGAGGTGCACTTTCACCTGAGCAAGGTGGAGGAACAAGAAAGTGACCTATGTGAGGAAAAGGATGTTTGTTTTGCACGAGCTGTGTCCCCCAATGTACACAGTAGGTGCTCAATAAACTTTTTTTTTTTTTTTTTTTTTTGAGACTGAGTCTGACTCTGTCGCCCAAGCTGGAGTGCAGTGGCACGATCTCAGCTGGCTGCAAACTCCGCCTCCCAGGTTCCAGCGATTCTCCTGCCTCAGCCTGCCGAGTAGCTGGTCTTACAGATGAGTGCCATCACGCCCACCTAATTTGTAGTATTTTTAGTAGAGACAAGGTTTCACCATGTTGGCCAGGCTGGTCTCCAACTCCTGTCTTCAAGTGATCCGCCCACCTCAGATTAC
CTGACATGTCTGTCAAGTGTCACCCATGATCACACTGGGTCCTCATAACAGTCCCAGGAAAGGACACTGAGGCTCAGACAAAGGTCACTTGCTCAAGGACACACAATGAGGGGAGTTGTGACAGGAGGTCATAAGCCTAGGGACCTGCTGACCCAGAGTCCACACAGCTCACCATGACACTTCAAATTTGTCACAGGAGCAGGAAAGGGGATTGAAATGGGGTCTCACCTCATTTTCGATGGTTAAAGCAGGGGACCAGGATCTTCTGGGGATGGGCTGTGGTGCGCGGGCCTGGGGCTTCCAGCGAGGCACCTGGGCTACTGAATAGGTGCTGAAGCCCAGGGCGGGCAGTGAGGCTGAGAACAGCAGCTCCGGAGGGTGCGCCTGGCTGTCTGAGCTGGGAAATATTACCACCTCGGATAAAGGAGGAGGGAAACTGAGTCAAGAGTACCCATGGAAAGCTATACATGCATGGAGACAAAAAACTCAAGGAAGGAAAAGAGTCCTGAGATGGGGAAAGGAAATGGAGGTGTGTGTGGTGGGGGGACAGTCAGATTCCAAGGAAATGATTGCAGAGAAGATTCACCAGGTGGAAAAAAAAACCCACCGGGAGGGTGGAGAGACCATGGAGTCGGGGGAGTGAAGGAGGAAGTAGGGGAAGAAACCCTTGAGGCAGGTTCTCGGGGGAGGAAGAGGTTTGGGGGAGGACGTTTTCTGGAATGAAGGAGATGTCCATAAACAGCAATAAATTTTCCTGGGGAAGCGGGGTATTAAAATGGAGGACCAGCCAGGCACGGTGGCTCATGCCTATAATCCAGCAGGCGGAGTTTGAAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAGGGAGGACCACTCACAGGAGGCATATGTTCCCAAGGGGAGACTGATATTAAGGGGCAGAGGGAGAAGATACAAGAGGGGGGAAGAGATATGCATGAGTGGGAGGTATTCATGGAAGCAGGCGATATCCATGGGGGCGATGAGGAAATGCCCACTGGGGGAGGAGTCCCAGCGGGGGAATATTCGTTGTTTGGGCTCACATCGCTGGGCACTGTCCTGCCATTGGGGTCCTTCACAACGAAAACGCCTTCGCTGACCGGCAGCCGTACCATCCAATTCACCTTCCGCCCCAGGGGATTATAAACGATGACCTGGAACTGGGGAGGCGGGGGTCAGAGAGGGCATGGGTCACAGCAGGCCTTCTCCAAACCCACCCACTTTGCACAGAAACACCCCTGGCTGGTCCTAGTGTGGTCACGGCACTTAAGGCCAAGCCCCCTCGAGATGCGTTGTTCTCTCTGCTGACCCAGCTTCGCAGCCCACGTAATTTCACTCCTGTATAGTCCTCCAAAAACATTTTCCAACTACCCCCTCTAAAGCCCATCTGCCCTAGATCCACCCCTCCCGTCCCGGCTCACGCGCGCCGCCGTCTGGCTGAGCGGGCAGATGCTGATGTTTAGCTGTTGGCAAAAGGTGAAGTGATCTTTGAAGCCTCTGAGCCGCGCCAGCGCGTTGCTCAGAAGAACCTGCGGAAGAGCGCAAAGGGACCGGTGGGTTCAGGACGCCAGGCCTGACTCCTCCCCTCTCCTCAGGCCCCGCCCCGTTCCGGTCTCTGTCCCGCCTCCCTCAAGAGTCGCCCCAAAACCCCTTCTAGCCCCACCCTGCTGCCCTTGACTATACCCCATAGCTGTCTCCGCCTCCTCTTGCCCACGCCCCGCCTCCTTCCCCCCTCCAAAGCCCCGCCCCGTTCCTGTATCTTTCCCCGCCTCCTACAAGCCCCGCCCCCACGAGCCCTTGTAGCCCCGCCACAGGGCTCTCGGCTACGCCTCACACCTGTCTCTGTCCCCTTTCCCAGGCCCTGGCCCCGCCCCTTCCTGTCTCCACCCCCGTGTCTCCCAAGTCTCGCCCCGCGCACCTCGCAAGGCCCCCAGCCTGCCGCAAGCTGGCGCGCGTAGTCGTTGGCCACGTGCTGGCGGGAGGTGCAGCTGACGGCGTCGTGATGCTGGAGCACAGCCATCGCCTCATCTGCTCATAGACAATGAGTCCGGTGAGGTTCTGTGGGACTCAGCTGAGACCCCAAGGGGAAGCGAAAGGTCCGGTGCTGGCGGGCAGGATTCTTAGAGGCTTTAAGAAGGAACTCGAGGACGGCTGGGGGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGACCGAGGCGGGCGGATCACGAGGTCAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGTCAGGAGAATGGCGTGAACACGGGAGGTGGAGCTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGAGACAAATCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAGAAGAAACTCGAGGGGGGCGGCCTAGGGGTGGTTTCCAACTTCAGCCGCAAACCTCTTCCCCTCTTGGGCCCGACACTTACTGAGGGGTGCACTGTCTCCGGAGCCATAGGGTCCCACGTTGGCCGCCAGGCCCACCAGCGCCTCCAGCTGGTTGCACACCTGGAGGCAGAGGGGTATGTTGGGGCGCCCAGCCTGTCGGGCCTCGGGGCTGCATGCCCCCTCTAGCCCGGCTCCTACCCACCTGCAGGAAGTTGTAGCTGAGGCGCTCGTAGCGTTTGAGGGCCGGCCGACTGGAAAAGTAACCGGTCCAGAACTGGTGGGGGCCATCCGCGTAAGGGAAGAAGTCGTCATGTTTCACTGACCTACAGCGGCAGGGGCATTGAGGGCAGGGTCATGACCCACGGGGCATGCCAACCCCCCCAAGCTCCCCAGTTTCCCCAAATACCAGGTGAGGTTGGCCTTGTTCAGCTCCCAGAGGTAACAAGCGGGGGTGGAGTAGAGAACATGGACACTGCTTCCTTTTGCCTGCTGCTGGGGGAGGCGACGGAGTGAGCCCTCGGGAGTCCGCACCTTCCTGGGGGCCCACACTTCCACACATGTGTGCACATTCATGCATCCCATAGGTTCAGTTTCTCTAAATACATATTTGGCGTGCAAGCCAATGGTTGGGTGTGAAAATGAATTTTGGCTGAAGTCAAACATGACCACTAGCCTTTTTTAAAAGGATTTCAGAGATGCAAGAATAAACCTGAAATTTTACTAAACTTTTACAATAATTCCAACTTTATTATTAAAAACTTTTGTGGAAAAACTAAGTGTGACATTATAGGGCAGGAATAATCGTTTTGCAGGACTGTCAGATTGTTACCAAAAAACACAACTTTTTTTTTTTGGGACGGAGTCTTACTTTGTTGCCCAGGCTGTAGTGCAGTGGCTCAATCTCAGCTCACTGCAAGCTCCACCTCTTGGGTTCACGCCATTCTCCAGCCTCAGCCTCATGAGTACCTGGGACTACAGGTGCCCGCCACCACACCCGGCTAATTTTTTGCATTTTTTAGTAGAGACGGAGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTGCCCGGCCTAGACACAATTTTTATAATGAATGGAGGTGCACTTTCACCTGAGCAAGGTGGAGGAACAAGAAAGTGACCTATGTGAGGAAAAGGATGTTTGTTTTGCACGAGCTGTGTCCCCCAATGTACACAGTAGGTGCTCAATAAACTTTTTTTTTTTTTTTTTTTTTTGAGACTGAGTCTGACTCTGTCGCCCAAGCTGGAGTGCAGTGGCACGATCTCAGCTGGCTGCAAACTCCGCCTCCCAGGTTCCAGCGATTCTCCTGCCTCAGCCTGCCGAGTAGCTGGTCTTACAGATGAGTGCCATCACGCCCACCTAATTTGTAGTATTTTTAGTAGAGACAAGGTTTCACCATGTTGGCCAGGCTGGTCTCCAACTCCTGTCTTCAAGTGATCCGCCCACCTCAGATTAC
Task1_train_26556
This variant affects the gene MAN2B1 (mannosidase alpha class 2B member 1) found on Chromosome 19. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; not specified
CTTGGCGGGTTGTAACCATTGGGAAGCACACCTGCAGGTCACACCAAGTTCAAGGGGTGGCCCATCACCCAGACCTTCCCTGGTTTCAAAGCCGGCCATGTCCCACCCAGGATGGGCTTCAGAATTTGTGTCCCAATGCAAAAGGAAATGCAGGGCCTTTGTTCCCAGACTATAGGAATTCCAGGACAGTGACAACAGAGCAGATATCAAGCCCAGGGCCCTTCTGAGTGTGTGGCACCATGGCTGGCCCTGCCCTCACCAAGCCCCCTACCAGTGAAGAGGTCCGCGGTCGGGGGCTTCAGGCTGGTGCTGGCCCGCCACACCTGCTCCATCTCCAGCTTCTGCATCCGTACCCACTTATCTTGATAATCAAGGCGCCCAAAGAAGAAGCCGTCGAAGCCCATCTGGGGATGAGGGAGGAAAAGGCAGTGTGAATTAGTGCCCAGCCCTCTCACCACCAAACTCCCCTCTGCTTGGGAGGGGCAGGTCAGAGCACAGGTTAAAAAGCAGTGCTAGGTCGATGTGGTGGCTCTTGCCTATGATCCCAGCCTTCTGGGAGGCCAAAACAGGAGGATCACTTAAACCCAGGAGTTTTTGAGACCAGCCTGCACAACACGGGCAGACTGTCTACAAAAAATTTAAAAATTAGCCAGGCGTAGTGGTGCGCTCTTGTAGTCTCATCTACTAGGGGGGCTGAGACAGGAGAATCGCTTGAATCCGGGAGATTGAGGCTATAGTGAGTTAGGATTGCACCACTGCACTCCAGCCTGGATGACAGCAAGACCCTGTCTCAAAAAACAAAAACAAAAACACGTAGGGCTGAAACAGAGAGGCCTCCAGCTTATTTCCAAGCTTGGGGAAGTTTCAGAACTCACCACCTTGGGCTAGCAGGGAGAGGGCGGGTCCAACATCAGAACCCAGGTTCACCTCCCCAGCACTGTCAAAGCGCAGAGCAGGCCTGACTCCAGGAATGAGGTTCCCCCTTCCACAGCCTGAGGATGGATGGGGTCTGAGCACAGGTAATGAACCTGTTTTTAAGGCAGCCTAGGCATCCACTTGCCACCCGGTTTAGGGAGGAGCCAGGACCCGAGCTAGTGGGTGGGGCCAGAACACCAAGAGGGGCCTATTAGGGGAGAGGGCGGAGCCAGCCGGAGCTGGGTCAGCCTGGGCTGGGCATAGCCGGCTGAGGCCAGAGCTCAAAAGCCACTGGCTTTACGGCTCACTCAAGGGGCAGGGCTTCAACAGGCCTAGGCCTGGGCCTGGTCCTTGTGAGATTGCAGGGAGAGGGCGGGGTTTGACTGGGCGAGGGAGGAGCCAGAGTGAGTGAAGAAGTGGGCCCAAGAGAGGTCCCGGGTCGCACCTGCGCAAACAGCGAGGCCTGCTCCCGAGAGTGGCCGAAGGGGTCAATGTGCCAGGCCACACGGGGTCGCCCATCATTGCCAAATGTGTCCTCCAGAAAGCGCAGCCCAAGTGTCATCTGGTCCACGATGGCACCGTAGTGGGTGGCTGCCTCATCGTTCATCACCCAGCCACCATTGGCGAACTCCAGGCGCCCTGTGCCAGGACAGGCAAGGTCAGGGTCAGCGGTCAGAGCCAGGAGTGGGAGTAGGGTGGGTGATACTGGGAATGTGAAAGCCTGCCTGTGTACACATTTCTGGCGGAAGGACAAGAGGGGTCGCTCCCAGGCCATAGTTCCCAGATATGGGAAAGAGGCCCCCTGCATGGCAGGCTTCCCAGAGGATGCACAGCAGGTGGGGCTTTGTGGGATGTATAGGAGGTCTCCAAATGGAGAGTCCAGGCAGGCGGAGCGACACGCATGTTATACAGCTTGCACGTGGCATGACAAATCTCAGAAACCAGAGATGCAGAAGCAGAAGCTGGGCTGGGCTTCCTCTTTTCACTTCCTTGGGGTAGGCTCACCCTGGCGCACAAGGTCTCGCACGACTTCCTGTGTGGCATTTGTCTGCTGGTGCCACCAACGGGAGAAGAAGGCAATCTCCACGTAAATGAAGCGACGGGTGGGATCTGCCAGCAAGGCAGAGATGACCGAGTCCAGGATGTACTGCACACCGGCGTGCTGGATGTCATTCTTGACTGTGGATAACAGGGATAAGGCTCTCAGGGAACAGCAGAGCCAAGGGGGTTATTCCTAGACAGAGGAGCCCAAACCCTGGATATTAGGGTAGCACTGGCCCCACCCTAATGTCCAGGACCCAGAGGGATTACAGGGACCATGGGGATCCCAGGGACCAGTCCCCATCCTCTACTCACTTCCATAAAAGTACTGGTCCACGGTTTTGAGCCAGCCCACGTCATCATGTGTGTGAGGCAGCAGGTGCACGTTCAGCATGTTCGGCTGCACTGTGGGGCATGTCTGCACAGGGACCCCAAACACACATACCTTGTCAATAACCCCCGAGGTCGGGGGCTGCAGAGTAAGTCTTGATCTAGAGGTGAGTGACTCAGAGAGGCCTGATCTCGCCTATGTGCAGAGGAGGCCAGGCCCTCCCAGGCAGGACACACACATACATAGTTGTGCTCATAGATACAACTCCACTTTGCACAACCCCACAGGGCAGCTCTCATTCACACTCCGGGAAAATAATAATAGAAGTAGCTGATGTTTGTTCAGCATTTGCCGACAGCAGACGGCCACCGTGGGAGGTGGGGTGATGTTATCCCCAGTTTCCAGATGAAGGCACTGAGGCTTAGAGAGGATAGGTGACTTGCCCAACGTCACACACTCAGGAAGTGTAAGAGCTAGGCTGGAATTTCAGGCAGACTCCAGAGTCCCAGCTCTCAGCCAGCACCTCCCCCCACACATACACTGCTCACCCCCTGCCACCTCCTGCCCCTCCAATCCCACAGTTAAGTGCAGACAAAGTCTAGGCAAGCATCCCGGAGACACGGAGGCAGGTACAATCAGACACAGTCCTATACTCAGATGCGCACAGCCAGACCTCGCAATGACACAAAGCACGCACTCAGACCACACTGTCATATCATCAGCCATTCACTAGACACCCACAGGACAGACCCACCCACACCTCTAGACTGTATTCTGGGTTTCACTCTGCCTCCTGTACGTTTCAGCTCGGAGGCCCCACTCACCTCGTATCCCCCGGCCCGAGCACCGGCAGCCGCCAGCAACAAAAGGAAAAAGCAGAGAGGCGGGAGCGGTGGCCGCAGGGCGCGGGACATGGTCCAGGGGCCTGCTGAGTCCAGGCAGCCGCGAGCGCAGACCCCCGAAGCCCGCGCGTAGGCGCCCATGGCTCAGCAGCTTCCTCCTGGGGTTCCCCGGCCCTGGAAAGGCCGGGCAAACGCCCCGCCCCCAGACCCGGCCGGGCCAATCGGGGTGGGGGGCGGGGCCAGGGCGCGGTCTGGAGGCTCACGGGAGAGAGGCTGTAGCCCTGGGCAATCCCGGGGGTCGTTACAGGAAGGTAGGAAAATGCCACCCTCAGGGCACTGGTTGGGCTAAAGGTGACACTGGCGTCTCACGGGCTATGAAGACGGAATGCCTCTTAATGCCGGAATTCCAAGACGGAATGCCTCTTAATGCCGGTAGGAGCAGAAGTGCTTTTCCTAAGGGGGCCGGGTTTTCCTAGCCGGTGTAGTGTGTCCATGGGAATCCAGGGTGTCCGTCCCATGGACCTTCAGCGCTAGGGTCCTGGAAGGACCTAGCTTGCCTAAGAGGAGGATCTGATGAAGAGTCCTATACTGTGGGGATTGGGACGTTGGGTAAATACCCCTGGAGTACCAGGGATGGGATCCAGCCTGGTTGAGAAGGATCCCTGGGTGTTCCGGAGAGAAAAGAGGGTCTGACAAGTGGGGAAGGACCCCGAGTCTTTCATGCCTTTCCCAATTCCTACCAGTTCATTCTCTGATAAGAAAACAAAGCCCAGGGCAGGCGCAGTGGCTCAAGCCTGCAATCCCAGCACTTTGGGAGGGCCAGGCTGGTGAATCACTTGGGCCTGGGAGTTTGAGACCAGCCTGGGCAACATGGGTTGTTTTGTAGAGACGGGTTTGAAAACACAAAATTTGTAATTTTACACAAAATGTAAAAATACAAAAATTAGCTGGGCATGGTGGCACATGC
CTTGGCGGGTTGTAACCATTGGGAAGCACACCTGCAGGTCACACCAAGTTCAAGGGGTGGCCCATCACCCAGACCTTCCCTGGTTTCAAAGCCGGCCATGTCCCACCCAGGATGGGCTTCAGAATTTGTGTCCCAATGCAAAAGGAAATGCAGGGCCTTTGTTCCCAGACTATAGGAATTCCAGGACAGTGACAACAGAGCAGATATCAAGCCCAGGGCCCTTCTGAGTGTGTGGCACCATGGCTGGCCCTGCCCTCACCAAGCCCCCTACCAGTGAAGAGGTCCGCGGTCGGGGGCTTCAGGCTGGTGCTGGCCCGCCACACCTGCTCCATCTCCAGCTTCTGCATCCGTACCCACTTATCTTGATAATCAAGGCGCCCAAAGAAGAAGCCGTCGAAGCCCATCTGGGGATGAGGGAGGAAAAGGCAGTGTGAATTAGTGCCCAGCCCTCTCACCACCAAACTCCCCTCTGCTTGGGAGGGGCAGGTCAGAGCACAGGTTAAAAAGCAGTGCTAGGTCGATGTGGTGGCTCTTGCCTATGATCCCAGCCTTCTGGGAGGCCAAAACAGGAGGATCACTTAAACCCAGGAGTTTTTGAGACCAGCCTGCACAACACGGGCAGACTGTCTACAAAAAATTTAAAAATTAGCCAGGCGTAGTGGTGCGCTCTTGTAGTCTCATCTACTAGGGGGGCTGAGACAGGAGAATCGCTTGAATCCGGGAGATTGAGGCTATAGTGAGTTAGGATTGCACCACTGCACTCCAGCCTGGATGACAGCAAGACCCTGTCTCAAAAAACAAAAACAAAAACACGTAGGGCTGAAACAGAGAGGCCTCCAGCTTATTTCCAAGCTTGGGGAAGTTTCAGAACTCACCACCTTGGGCTAGCAGGGAGAGGGCGGGTCCAACATCAGAACCCAGGTTCACCTCCCCAGCACTGTCAAAGCGCAGAGCAGGCCTGACTCCAGGAATGAGGTTCCCCCTTCCACAGCCTGAGGATGGATGGGGTCTGAGCACAGGTAATGAACCTGTTTTTAAGGCAGCCTAGGCATCCACTTGCCACCCGGTTTAGGGAGGAGCCAGGACCCGAGCTAGTGGGTGGGGCCAGAACACCAAGAGGGGCCTATTAGGGGAGAGGGCGGAGCCAGCCGGAGCTGGGTCAGCCTGGGCTGGGCATAGCCGGCTGAGGCCAGAGCTCAAAAGCCACTGGCTTTACGGCTCACTCAAGGGGCAGGGCTTCAACAGGCCTAGGCCTGGGCCTGGTCCTTGTGAGATTGCAGGGAGAGGGCGGGGTTTGACTGGGCGAGGGAGGAGCCAGAGTGAGTGAAGAAGTGGGCCCAAGAGAGGTCCCGGGTCGCACCTGCGCAAACAGCGAGGCCTGCTCCCGAGAGTGGCCGAAGGGGTCAATGTGCCAGGCCACACGGGGTCGCCCATCATTGCCAAATGTGTCCTCCAGAAAGCGCAGCCCAAGTGTCATCTGGTCCACGATGGCACCGTAGTGGGTGGCTGCCTCATCGTTCATCACCCAGCCACCATTGGCGAACTCCAGGCGCCCTGTGCCAGGACAGGCAAGGTCAGGGTCAGCGGTCAGAGCCAGGAGTGGGAGTAGGGTGGGTGATACTGGGAATGTGAAAGCCTGCCTGTGTACACATTTCTGGCGGAAGGACAAGAGGGGTCGCTCCCAGGCCATAGTTCCCAGATATGGGAAAGAGGCCCCCTGCATGGCAGGCTTCCCAGAGGATGCACAGCAGGTGGGGCTTTGTGGGATGTATAGGAGGTCTCCAAATGGAGAGTCCAGGCAGGCGGAGCGACACGCATGTTATACAGCTTGCACGTGGCATGACAAATCTCAGAAACCAGAGATGCAGAAGCAGAAGCTGGGCTGGGCTTCCTCTTTTCACTTCCTTGGGGTAGGCTCACCCTGGCGCACAAGGTCTCGCACGACTTCCTGTGTGGCATTTGTCTGCTGGTGCCACCAACGGGAGAAGAAGGCAATCTCCACGTAAATGAAGCGACGGGTGGGATCTGCCAGCAAGGCAGAGATGACCAAGTCCAGGATGTACTGCACACCGGCGTGCTGGATGTCATTCTTGACTGTGGATAACAGGGATAAGGCTCTCAGGGAACAGCAGAGCCAAGGGGGTTATTCCTAGACAGAGGAGCCCAAACCCTGGATATTAGGGTAGCACTGGCCCCACCCTAATGTCCAGGACCCAGAGGGATTACAGGGACCATGGGGATCCCAGGGACCAGTCCCCATCCTCTACTCACTTCCATAAAAGTACTGGTCCACGGTTTTGAGCCAGCCCACGTCATCATGTGTGTGAGGCAGCAGGTGCACGTTCAGCATGTTCGGCTGCACTGTGGGGCATGTCTGCACAGGGACCCCAAACACACATACCTTGTCAATAACCCCCGAGGTCGGGGGCTGCAGAGTAAGTCTTGATCTAGAGGTGAGTGACTCAGAGAGGCCTGATCTCGCCTATGTGCAGAGGAGGCCAGGCCCTCCCAGGCAGGACACACACATACATAGTTGTGCTCATAGATACAACTCCACTTTGCACAACCCCACAGGGCAGCTCTCATTCACACTCCGGGAAAATAATAATAGAAGTAGCTGATGTTTGTTCAGCATTTGCCGACAGCAGACGGCCACCGTGGGAGGTGGGGTGATGTTATCCCCAGTTTCCAGATGAAGGCACTGAGGCTTAGAGAGGATAGGTGACTTGCCCAACGTCACACACTCAGGAAGTGTAAGAGCTAGGCTGGAATTTCAGGCAGACTCCAGAGTCCCAGCTCTCAGCCAGCACCTCCCCCCACACATACACTGCTCACCCCCTGCCACCTCCTGCCCCTCCAATCCCACAGTTAAGTGCAGACAAAGTCTAGGCAAGCATCCCGGAGACACGGAGGCAGGTACAATCAGACACAGTCCTATACTCAGATGCGCACAGCCAGACCTCGCAATGACACAAAGCACGCACTCAGACCACACTGTCATATCATCAGCCATTCACTAGACACCCACAGGACAGACCCACCCACACCTCTAGACTGTATTCTGGGTTTCACTCTGCCTCCTGTACGTTTCAGCTCGGAGGCCCCACTCACCTCGTATCCCCCGGCCCGAGCACCGGCAGCCGCCAGCAACAAAAGGAAAAAGCAGAGAGGCGGGAGCGGTGGCCGCAGGGCGCGGGACATGGTCCAGGGGCCTGCTGAGTCCAGGCAGCCGCGAGCGCAGACCCCCGAAGCCCGCGCGTAGGCGCCCATGGCTCAGCAGCTTCCTCCTGGGGTTCCCCGGCCCTGGAAAGGCCGGGCAAACGCCCCGCCCCCAGACCCGGCCGGGCCAATCGGGGTGGGGGGCGGGGCCAGGGCGCGGTCTGGAGGCTCACGGGAGAGAGGCTGTAGCCCTGGGCAATCCCGGGGGTCGTTACAGGAAGGTAGGAAAATGCCACCCTCAGGGCACTGGTTGGGCTAAAGGTGACACTGGCGTCTCACGGGCTATGAAGACGGAATGCCTCTTAATGCCGGAATTCCAAGACGGAATGCCTCTTAATGCCGGTAGGAGCAGAAGTGCTTTTCCTAAGGGGGCCGGGTTTTCCTAGCCGGTGTAGTGTGTCCATGGGAATCCAGGGTGTCCGTCCCATGGACCTTCAGCGCTAGGGTCCTGGAAGGACCTAGCTTGCCTAAGAGGAGGATCTGATGAAGAGTCCTATACTGTGGGGATTGGGACGTTGGGTAAATACCCCTGGAGTACCAGGGATGGGATCCAGCCTGGTTGAGAAGGATCCCTGGGTGTTCCGGAGAGAAAAGAGGGTCTGACAAGTGGGGAAGGACCCCGAGTCTTTCATGCCTTTCCCAATTCCTACCAGTTCATTCTCTGATAAGAAAACAAAGCCCAGGGCAGGCGCAGTGGCTCAAGCCTGCAATCCCAGCACTTTGGGAGGGCCAGGCTGGTGAATCACTTGGGCCTGGGAGTTTGAGACCAGCCTGGGCAACATGGGTTGTTTTGTAGAGACGGGTTTGAAAACACAAAATTTGTAATTTTACACAAAATGTAAAAATACAAAAATTAGCTGGGCATGGTGGCACATGC
Task1_train_26557
Given a variant located on Chromosome 19 and affecting MAN2B1 (mannosidase alpha class 2B member 1), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Deficiency of alpha-mannosidase
CTTGGCGGGTTGTAACCATTGGGAAGCACACCTGCAGGTCACACCAAGTTCAAGGGGTGGCCCATCACCCAGACCTTCCCTGGTTTCAAAGCCGGCCATGTCCCACCCAGGATGGGCTTCAGAATTTGTGTCCCAATGCAAAAGGAAATGCAGGGCCTTTGTTCCCAGACTATAGGAATTCCAGGACAGTGACAACAGAGCAGATATCAAGCCCAGGGCCCTTCTGAGTGTGTGGCACCATGGCTGGCCCTGCCCTCACCAAGCCCCCTACCAGTGAAGAGGTCCGCGGTCGGGGGCTTCAGGCTGGTGCTGGCCCGCCACACCTGCTCCATCTCCAGCTTCTGCATCCGTACCCACTTATCTTGATAATCAAGGCGCCCAAAGAAGAAGCCGTCGAAGCCCATCTGGGGATGAGGGAGGAAAAGGCAGTGTGAATTAGTGCCCAGCCCTCTCACCACCAAACTCCCCTCTGCTTGGGAGGGGCAGGTCAGAGCACAGGTTAAAAAGCAGTGCTAGGTCGATGTGGTGGCTCTTGCCTATGATCCCAGCCTTCTGGGAGGCCAAAACAGGAGGATCACTTAAACCCAGGAGTTTTTGAGACCAGCCTGCACAACACGGGCAGACTGTCTACAAAAAATTTAAAAATTAGCCAGGCGTAGTGGTGCGCTCTTGTAGTCTCATCTACTAGGGGGGCTGAGACAGGAGAATCGCTTGAATCCGGGAGATTGAGGCTATAGTGAGTTAGGATTGCACCACTGCACTCCAGCCTGGATGACAGCAAGACCCTGTCTCAAAAAACAAAAACAAAAACACGTAGGGCTGAAACAGAGAGGCCTCCAGCTTATTTCCAAGCTTGGGGAAGTTTCAGAACTCACCACCTTGGGCTAGCAGGGAGAGGGCGGGTCCAACATCAGAACCCAGGTTCACCTCCCCAGCACTGTCAAAGCGCAGAGCAGGCCTGACTCCAGGAATGAGGTTCCCCCTTCCACAGCCTGAGGATGGATGGGGTCTGAGCACAGGTAATGAACCTGTTTTTAAGGCAGCCTAGGCATCCACTTGCCACCCGGTTTAGGGAGGAGCCAGGACCCGAGCTAGTGGGTGGGGCCAGAACACCAAGAGGGGCCTATTAGGGGAGAGGGCGGAGCCAGCCGGAGCTGGGTCAGCCTGGGCTGGGCATAGCCGGCTGAGGCCAGAGCTCAAAAGCCACTGGCTTTACGGCTCACTCAAGGGGCAGGGCTTCAACAGGCCTAGGCCTGGGCCTGGTCCTTGTGAGATTGCAGGGAGAGGGCGGGGTTTGACTGGGCGAGGGAGGAGCCAGAGTGAGTGAAGAAGTGGGCCCAAGAGAGGTCCCGGGTCGCACCTGCGCAAACAGCGAGGCCTGCTCCCGAGAGTGGCCGAAGGGGTCAATGTGCCAGGCCACACGGGGTCGCCCATCATTGCCAAATGTGTCCTCCAGAAAGCGCAGCCCAAGTGTCATCTGGTCCACGATGGCACCGTAGTGGGTGGCTGCCTCATCGTTCATCACCCAGCCACCATTGGCGAACTCCAGGCGCCCTGTGCCAGGACAGGCAAGGTCAGGGTCAGCGGTCAGAGCCAGGAGTGGGAGTAGGGTGGGTGATACTGGGAATGTGAAAGCCTGCCTGTGTACACATTTCTGGCGGAAGGACAAGAGGGGTCGCTCCCAGGCCATAGTTCCCAGATATGGGAAAGAGGCCCCCTGCATGGCAGGCTTCCCAGAGGATGCACAGCAGGTGGGGCTTTGTGGGATGTATAGGAGGTCTCCAAATGGAGAGTCCAGGCAGGCGGAGCGACACGCATGTTATACAGCTTGCACGTGGCATGACAAATCTCAGAAACCAGAGATGCAGAAGCAGAAGCTGGGCTGGGCTTCCTCTTTTCACTTCCTTGGGGTAGGCTCACCCTGGCGCACAAGGTCTCGCACGACTTCCTGTGTGGCATTTGTCTGCTGGTGCCACCAACGGGAGAAGAAGGCAATCTCCACGTAAATGAAGCGACGGGTGGGATCTGCCAGCAAGGCAGAGATGACCGAGTCCAGGATGTACTGCACACCGGCGTGCTGGATGTCATTCTTGACTGTGGATAACAGGGATAAGGCTCTCAGGGAACAGCAGAGCCAAGGGGGTTATTCCTAGACAGAGGAGCCCAAACCCTGGATATTAGGGTAGCACTGGCCCCACCCTAATGTCCAGGACCCAGAGGGATTACAGGGACCATGGGGATCCCAGGGACCAGTCCCCATCCTCTACTCACTTCCATAAAAGTACTGGTCCACGGTTTTGAGCCAGCCCACGTCATCATGTGTGTGAGGCAGCAGGTGCACGTTCAGCATGTTCGGCTGCACTGTGGGGCATGTCTGCACAGGGACCCCAAACACACATACCTTGTCAATAACCCCCGAGGTCGGGGGCTGCAGAGTAAGTCTTGATCTAGAGGTGAGTGACTCAGAGAGGCCTGATCTCGCCTATGTGCAGAGGAGGCCAGGCCCTCCCAGGCAGGACACACACATACATAGTTGTGCTCATAGATACAACTCCACTTTGCACAACCCCACAGGGCAGCTCTCATTCACACTCCGGGAAAATAATAATAGAAGTAGCTGATGTTTGTTCAGCATTTGCCGACAGCAGACGGCCACCGTGGGAGGTGGGGTGATGTTATCCCCAGTTTCCAGATGAAGGCACTGAGGCTTAGAGAGGATAGGTGACTTGCCCAACGTCACACACTCAGGAAGTGTAAGAGCTAGGCTGGAATTTCAGGCAGACTCCAGAGTCCCAGCTCTCAGCCAGCACCTCCCCCCACACATACACTGCTCACCCCCTGCCACCTCCTGCCCCTCCAATCCCACAGTTAAGTGCAGACAAAGTCTAGGCAAGCATCCCGGAGACACGGAGGCAGGTACAATCAGACACAGTCCTATACTCAGATGCGCACAGCCAGACCTCGCAATGACACAAAGCACGCACTCAGACCACACTGTCATATCATCAGCCATTCACTAGACACCCACAGGACAGACCCACCCACACCTCTAGACTGTATTCTGGGTTTCACTCTGCCTCCTGTACGTTTCAGCTCGGAGGCCCCACTCACCTCGTATCCCCCGGCCCGAGCACCGGCAGCCGCCAGCAACAAAAGGAAAAAGCAGAGAGGCGGGAGCGGTGGCCGCAGGGCGCGGGACATGGTCCAGGGGCCTGCTGAGTCCAGGCAGCCGCGAGCGCAGACCCCCGAAGCCCGCGCGTAGGCGCCCATGGCTCAGCAGCTTCCTCCTGGGGTTCCCCGGCCCTGGAAAGGCCGGGCAAACGCCCCGCCCCCAGACCCGGCCGGGCCAATCGGGGTGGGGGGCGGGGCCAGGGCGCGGTCTGGAGGCTCACGGGAGAGAGGCTGTAGCCCTGGGCAATCCCGGGGGTCGTTACAGGAAGGTAGGAAAATGCCACCCTCAGGGCACTGGTTGGGCTAAAGGTGACACTGGCGTCTCACGGGCTATGAAGACGGAATGCCTCTTAATGCCGGAATTCCAAGACGGAATGCCTCTTAATGCCGGTAGGAGCAGAAGTGCTTTTCCTAAGGGGGCCGGGTTTTCCTAGCCGGTGTAGTGTGTCCATGGGAATCCAGGGTGTCCGTCCCATGGACCTTCAGCGCTAGGGTCCTGGAAGGACCTAGCTTGCCTAAGAGGAGGATCTGATGAAGAGTCCTATACTGTGGGGATTGGGACGTTGGGTAAATACCCCTGGAGTACCAGGGATGGGATCCAGCCTGGTTGAGAAGGATCCCTGGGTGTTCCGGAGAGAAAAGAGGGTCTGACAAGTGGGGAAGGACCCCGAGTCTTTCATGCCTTTCCCAATTCCTACCAGTTCATTCTCTGATAAGAAAACAAAGCCCAGGGCAGGCGCAGTGGCTCAAGCCTGCAATCCCAGCACTTTGGGAGGGCCAGGCTGGTGAATCACTTGGGCCTGGGAGTTTGAGACCAGCCTGGGCAACATGGGTTGTTTTGTAGAGACGGGTTTGAAAACACAAAATTTGTAATTTTACACAAAATGTAAAAATACAAAAATTAGCTGGGCATGGTGGCACATGC
CTTGGCGGGTTGTAACCATTGGGAAGCACACCTGCAGGTCACACCAAGTTCAAGGGGTGGCCCATCACCCAGACCTTCCCTGGTTTCAAAGCCGGCCATGTCCCACCCAGGATGGGCTTCAGAATTTGTGTCCCAATGCAAAAGGAAATGCAGGGCCTTTGTTCCCAGACTATAGGAATTCCAGGACAGTGACAACAGAGCAGATATCAAGCCCAGGGCCCTTCTGAGTGTGTGGCACCATGGCTGGCCCTGCCCTCACCAAGCCCCCTACCAGTGAAGAGGTCCGCGGTCGGGGGCTTCAGGCTGGTGCTGGCCCGCCACACCTGCTCCATCTCCAGCTTCTGCATCCGTACCCACTTATCTTGATAATCAAGGCGCCCAAAGAAGAAGCCGTCGAAGCCCATCTGGGGATGAGGGAGGAAAAGGCAGTGTGAATTAGTGCCCAGCCCTCTCACCACCAAACTCCCCTCTGCTTGGGAGGGGCAGGTCAGAGCACAGGTTAAAAAGCAGTGCTAGGTCGATGTGGTGGCTCTTGCCTATGATCCCAGCCTTCTGGGAGGCCAAAACAGGAGGATCACTTAAACCCAGGAGTTTTTGAGACCAGCCTGCACAACACGGGCAGACTGTCTACAAAAAATTTAAAAATTAGCCAGGCGTAGTGGTGCGCTCTTGTAGTCTCATCTACTAGGGGGGCTGAGACAGGAGAATCGCTTGAATCCGGGAGATTGAGGCTATAGTGAGTTAGGATTGCACCACTGCACTCCAGCCTGGATGACAGCAAGACCCTGTCTCAAAAAACAAAAACAAAAACACGTAGGGCTGAAACAGAGAGGCCTCCAGCTTATTTCCAAGCTTGGGGAAGTTTCAGAACTCACCACCTTGGGCTAGCAGGGAGAGGGCGGGTCCAACATCAGAACCCAGGTTCACCTCCCCAGCACTGTCAAAGCGCAGAGCAGGCCTGACTCCAGGAATGAGGTTCCCCCTTCCACAGCCTGAGGATGGATGGGGTCTGAGCACAGGTAATGAACCTGTTTTTAAGGCAGCCTAGGCATCCACTTGCCACCCGGTTTAGGGAGGAGCCAGGACCCGAGCTAGTGGGTGGGGCCAGAACACCAAGAGGGGCCTATTAGGGGAGAGGGCGGAGCCAGCCGGAGCTGGGTCAGCCTGGGCTGGGCATAGCCGGCTGAGGCCAGAGCTCAAAAGCCACTGGCTTTACGGCTCACTCAAGGGGCAGGGCTTCAACAGGCCTAGGCCTGGGCCTGGTCCTTGTGAGATTGCAGGGAGAGGGCGGGGTTTGACTGGGCGAGGGAGGAGCCAGAGTGAGTGAAGAAGTGGGCCCAAGAGAGGTCCCGGGTCGCACCTGCGCAAACAGCGAGGCCTGCTCCCGAGAGTGGCCGAAGGGGTCAATGTGCCAGGCCACACGGGGTCGCCCATCATTGCCAAATGTGTCCTCCAGAAAGCGCAGCCCAAGTGTCATCTGGTCCACGATGGCACCGTAGTGGGTGGCTGCCTCATCGTTCATCACCCAGCCACCATTGGCGAACTCCAGGCGCCCTGTGCCAGGACAGGCAAGGTCAGGGTCAGCGGTCAGAGCCAGGAGTGGGAGTAGGGTGGGTGATACTGGGAATGTGAAAGCCTGCCTGTGTACACATTTCTGGCGGAAGGACAAGAGGGGTCGCTCCCAGGCCATAGTTCCCAGATATGGGAAAGAGGCCCCCTGCATGGCAGGCTTCCCAGAGGATGCACAGCAGGTGGGGCTTTGTGGGATGTATAGGAGGTCTCCAAATGGAGAGTCCAGGCAGGCGGAGCGACACGCATGTTATACAGCTTGCACGTGGCATGACAAATCTCAGAAACCAGAGATGCAGAAGCAGAAGCTGGGCTGGGCTTCCTCTTTTCACTTCCTTGGGGTAGGCTCACCCTGGCGCACAAGGTCTCGCACGACTTCCTGTGTGGCATTTGTCTGCTGGTGCCACCAACGGGAGAAGAAGGCAATCTCCACGTAAATGAAGCGACGGGTGGGATCTGCCAGCAAGGCAGAGATGACCAAGTCCAGGATGTACTGCACACCGGCGTGCTGGATGTCATTCTTGACTGTGGATAACAGGGATAAGGCTCTCAGGGAACAGCAGAGCCAAGGGGGTTATTCCTAGACAGAGGAGCCCAAACCCTGGATATTAGGGTAGCACTGGCCCCACCCTAATGTCCAGGACCCAGAGGGATTACAGGGACCATGGGGATCCCAGGGACCAGTCCCCATCCTCTACTCACTTCCATAAAAGTACTGGTCCACGGTTTTGAGCCAGCCCACGTCATCATGTGTGTGAGGCAGCAGGTGCACGTTCAGCATGTTCGGCTGCACTGTGGGGCATGTCTGCACAGGGACCCCAAACACACATACCTTGTCAATAACCCCCGAGGTCGGGGGCTGCAGAGTAAGTCTTGATCTAGAGGTGAGTGACTCAGAGAGGCCTGATCTCGCCTATGTGCAGAGGAGGCCAGGCCCTCCCAGGCAGGACACACACATACATAGTTGTGCTCATAGATACAACTCCACTTTGCACAACCCCACAGGGCAGCTCTCATTCACACTCCGGGAAAATAATAATAGAAGTAGCTGATGTTTGTTCAGCATTTGCCGACAGCAGACGGCCACCGTGGGAGGTGGGGTGATGTTATCCCCAGTTTCCAGATGAAGGCACTGAGGCTTAGAGAGGATAGGTGACTTGCCCAACGTCACACACTCAGGAAGTGTAAGAGCTAGGCTGGAATTTCAGGCAGACTCCAGAGTCCCAGCTCTCAGCCAGCACCTCCCCCCACACATACACTGCTCACCCCCTGCCACCTCCTGCCCCTCCAATCCCACAGTTAAGTGCAGACAAAGTCTAGGCAAGCATCCCGGAGACACGGAGGCAGGTACAATCAGACACAGTCCTATACTCAGATGCGCACAGCCAGACCTCGCAATGACACAAAGCACGCACTCAGACCACACTGTCATATCATCAGCCATTCACTAGACACCCACAGGACAGACCCACCCACACCTCTAGACTGTATTCTGGGTTTCACTCTGCCTCCTGTACGTTTCAGCTCGGAGGCCCCACTCACCTCGTATCCCCCGGCCCGAGCACCGGCAGCCGCCAGCAACAAAAGGAAAAAGCAGAGAGGCGGGAGCGGTGGCCGCAGGGCGCGGGACATGGTCCAGGGGCCTGCTGAGTCCAGGCAGCCGCGAGCGCAGACCCCCGAAGCCCGCGCGTAGGCGCCCATGGCTCAGCAGCTTCCTCCTGGGGTTCCCCGGCCCTGGAAAGGCCGGGCAAACGCCCCGCCCCCAGACCCGGCCGGGCCAATCGGGGTGGGGGGCGGGGCCAGGGCGCGGTCTGGAGGCTCACGGGAGAGAGGCTGTAGCCCTGGGCAATCCCGGGGGTCGTTACAGGAAGGTAGGAAAATGCCACCCTCAGGGCACTGGTTGGGCTAAAGGTGACACTGGCGTCTCACGGGCTATGAAGACGGAATGCCTCTTAATGCCGGAATTCCAAGACGGAATGCCTCTTAATGCCGGTAGGAGCAGAAGTGCTTTTCCTAAGGGGGCCGGGTTTTCCTAGCCGGTGTAGTGTGTCCATGGGAATCCAGGGTGTCCGTCCCATGGACCTTCAGCGCTAGGGTCCTGGAAGGACCTAGCTTGCCTAAGAGGAGGATCTGATGAAGAGTCCTATACTGTGGGGATTGGGACGTTGGGTAAATACCCCTGGAGTACCAGGGATGGGATCCAGCCTGGTTGAGAAGGATCCCTGGGTGTTCCGGAGAGAAAAGAGGGTCTGACAAGTGGGGAAGGACCCCGAGTCTTTCATGCCTTTCCCAATTCCTACCAGTTCATTCTCTGATAAGAAAACAAAGCCCAGGGCAGGCGCAGTGGCTCAAGCCTGCAATCCCAGCACTTTGGGAGGGCCAGGCTGGTGAATCACTTGGGCCTGGGAGTTTGAGACCAGCCTGGGCAACATGGGTTGTTTTGTAGAGACGGGTTTGAAAACACAAAATTTGTAATTTTACACAAAATGTAAAAATACAAAAATTAGCTGGGCATGGTGGCACATGC
Task1_train_26558
A mutation found in TNPO2 (transportin 2) on Chromosome 19 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies
CAACATGGCAAAACCCTGTCTTTACTAAAAATACAATAAAATTAGCCAGGCATAGTGGGACACGCCTGTAGTCCCAGCTTCTTGAGAGGCTAAGGCAGGAGAACTGCTTGAACCCTGGAGGTGAAGGTTGCAGTGAGCCGAGATCACACCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAACAGGTGGGGGGCGGTGGGGGGGGCATAGTGTTTGCATATGCACCTATGCACATTCTCCTGTACACTTAGCATCATCTCTAAATCACTTATATCTAATACAATGTCAACAGTATGGGAATAGTTGTTATACTGTATTGTTTAGGGAATAATAACAAGAACAAACTTCTGTATGCGTTCAGTACAGATGTAATTTTTCCTCTGAGTATTTTCAATCTGAGGTTACTTGAATCTTGGGATGTAGAACCCACAGATACAGAGAGCCAACTGTGCTGGGGCAGGGACTTGGGCTTTCACATTTTCTATTTTCTTTTCTTTCTTTTTTTTTGAAGACAGAGTCTCAGTTTATTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTTCCAAGTAGCTGGGATTACAGGCGCCTACCACCATGCCTGGCTAATTTTTGTATTTTTCGTAGAGACAGGATTTCACCGTGTTGGCCAAGCTGCTCTCAAACTCCTGACCTCAAGTGATTCACCTGCCACAGCCTCCCAAAGTGCTGGATTATAGGCGTGAGCACCTGGCCTCACATTTTCTATTTTCAATACTGTTTGCTTTAAAAAAAATTTTTTTTTTTAATTTTAGAACTGGGGTTTCACTATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCAATCCTGCCTCGGCCTCCAGGATTACTCTTTAAAATAATTAGAACAGCACCTTTTCCCTGATTTCCTTTGGGCACAACCAGGCCCTGACTCCCCACCAGGGGCAGCCCACGCAGGCTGCTGGGTGTCATCACTGTCCAGGGTCCCCACCCACCTGCATGCACTGGAACAGCAATGTCATGATGTTGCTGCGGGCCACCAGCTGCTCCACGTGACCACCCAGGCCCTCGGCCAGGCCGCTGAGCAGATCCAGTGCTACGATCATGAAGTCCTTGTCGGGAGCCTCATACTGCTCAGGGTGCTGGGTGTACATCTAGACACAGATGCCGACAGGGGCACGGGTAAGTGGAGCAGGCCCGAGGCAGGCCAATGCAGAAGCACAGGTGACGGGCCTAGGGTTGCTCACCATGGCCTGAGCCAGTGTCTTCTGCACCAGGGTGACACAGCGCTGGTAGACGGGCTCACAGTAAGGCAGGAAGCCACTCTGCAGGGCGGTGGCCACCGATGACAGACACTGGCAGGGAGGAAGGCAGGTGGGGAGAACTCAGGCAGGGTGGGCAGGATGGGTTTCGGGTGAGGGGCAGGAGCCCACTCACCTCCAGCAGGGGGAAGAGGTCCTTGTCTTCGTCCTTGAGCTCATTCCACTTCTGGATCAGTGGGGGCATCAGCTTCTGGATGTATTCCTGGAGAGGGAGCACGAAATGGGCGCTCCCTGGGTCGGGGTGGCAGACTGTGACTCAGGTACCTGTTGCCCGAGTGATGAGGCCTGAGCGCCTCACCGTGGCTCATGGGACCCTGAAAGGCCTGCCATCTGGCCAGACCTCGAGGCCTTCATTCTTCTCACCTGTCCAAGCACCGCCCGCCCCACCCCACCCCCCGGGAGCCTGGGTTACCACCTCCTGGTTCCCGAAGCACAGCACTTACCACGCTGTCTCATAACTGTCTTTCTCCCCCACTAGACTGGGAGCAGGGCGAGGGCGGGGCCGGGTCTGTCTGTCTGCCTGTCGAGGTCACGGCCACGTCCCTGGCGTGCAACACGGGGTTGCCACCAGGTCACTGGATGCCCAGGGGCACGGGGATCGGGAGGCGGGAGCCGCTCTGGGGTCTCACCGGCTGGTTGAGGTGGTGGCCTACAGAGTCGGCCAGGGTGCCAATGGCGTCATAGAGGATGAGCAGGTTCTTGTGCTGGTATTTCCCAAAGGCAAAGACAAGGGTGTCCAGGATGTAGCTGAGGTAGGGCACCAGCTCCGTGCAGGCCTCTTCCTCCAGGGTGGCAAAAGCACTGGTGGGAGGGAGGATGAAGCGGGGGCTCAGTGGACCATGGCAGGTGACACTGGGCCATGGGCAGTTGGGGAGGGCAACTCAGGATCAGCCAGTACGAATACGCGATAAATCAGTTCCACATCAACAGTCACAGGTGTCATCACTTCCCAGAGGGTGGCCGGGGGAGAGTGGGGGCTGTGGGATCAGGGGTCCAGGGTCACCTGCAGGCCGCCTCCTGTACCCTCTTGTTGCCATCCAGGATGCGTTTGAGCAGCTCTGTCATCAGGGGCTTGAGGTGCATGTCGGGTGGCTGGCTGACCACCCAGTGGGCATAGCGGCTCAGCGTCCAGCAGGCGATGGAGCGGACCAAGGCCTTCTTATCCGACAGGCACTGGATCAGGTGCGGGATCAGCTCAGGCAGGTAGGGCACCATGCCCTGCATGCAGCCTACAAGGAAAGGGAACCAAGAGGGGGCAGTTTGATTGGGCCCAGCCACACCCACCGTATGGAGAGAAGAGTCAGCCGCACACAACATATAGGGAAACTGAGGCTTAGAGTTTAAATCACTGGCCCAGACTCATTTCACAGAGCCAGGTAAAGGCAGGCACAGGAGGGGAAACAACAGAAGCCTCTCATCCCAAAGCCCCGGGTTATCTTTATTTTTTTTTGAGGCAGAGTCTCGCTCTGTCGCCCAGGCTGGGGCGCAGTGGTACGATCATGGCTCACCGCAACCTTCACCTCCTGGTTCAAACAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCCTCTGCCACAATGCCCGGGGAATTTTTTATATTTTCAGTAGAGACAGGGTTTTACCATGTTGACCAAGATGGTCTCAGTCTCCTGACCTCGTGATCCACCCGCCCTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCAAAGAGCTCCGTGTTATTGCGTTAATTCAATTCATGCATTAATTCATGTGTTAATTGAATTCATGTGTTAATTCAAAATTGGCTCCGTTACATAGTGAGTGGGGTTTTATGGGGCAGCAGTGACCCAAATGGAATAAAAGCACTTTGCATTTGAAACAGTTCTTAAGATGTTTGTGAGTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTAGAGTGCAGTGGTGTGATCTGGGCTCACTGCAGCCTCTGCCTCCCGGGTTCAAGTGATTTCCTGCCTAAGCCTCCCAAGTAGCTGGGACTGCAGGCGCCCGCCACCATACCCAACTAATTTTTATATTTTTAGTAGAGACGGGGTTTTACCATGTTGGCTAGACTGGTCTTAAAATCCCGACCTCACGTGATCCCACCTCAGCCTCCCAGAGTGCTGCGATTATAGGTGTCTGGCCGTTTATGATTGTTCTATTTCTCCTTATTTTTGTTTAATTTTTTAATTTATTATTATTATTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAAGCTGAAGTACAGTTGCACAATCTTGGCTCACTGCAACCTCCGCCTCCCTGATTCAAGCAATTTTCCTGCCTCAACCTCCCCAGTAGCTGGGACTACAGGCGTGGGCCACCACGTGTGGCTAATTTTTCATATTTTTAGCAGAGACGAAGTTTCACCGTGTTAGCCAGGCTGGTCTCGAACTCCTGACCTCAGTTGATTCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCAGCCATTTTTAACAATTTTTTAATGTTTTCTTTGAGACAGAGTCTCGCTCTGTCCCCCAAGGAGGAGTGCAGTGGTGTGATCTCCACTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTGTCGTGCCTCAGCCTCCCAATAGCTAGGACTACAG
CAACATGGCAAAACCCTGTCTTTACTAAAAATACAATAAAATTAGCCAGGCATAGTGGGACACGCCTGTAGTCCCAGCTTCTTGAGAGGCTAAGGCAGGAGAACTGCTTGAACCCTGGAGGTGAAGGTTGCAGTGAGCCGAGATCACACCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAACAGGTGGGGGGCGGTGGGGGGGGCATAGTGTTTGCATATGCACCTATGCACATTCTCCTGTACACTTAGCATCATCTCTAAATCACTTATATCTAATACAATGTCAACAGTATGGGAATAGTTGTTATACTGTATTGTTTAGGGAATAATAACAAGAACAAACTTCTGTATGCGTTCAGTACAGATGTAATTTTTCCTCTGAGTATTTTCAATCTGAGGTTACTTGAATCTTGGGATGTAGAACCCACAGATACAGAGAGCCAACTGTGCTGGGGCAGGGACTTGGGCTTTCACATTTTCTATTTTCTTTTCTTTCTTTTTTTTTGAAGACAGAGTCTCAGTTTATTGCCCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTTCCAAGTAGCTGGGATTACAGGCGCCTACCACCATGCCTGGCTAATTTTTGTATTTTTCGTAGAGACAGGATTTCACCGTGTTGGCCAAGCTGCTCTCAAACTCCTGACCTCAAGTGATTCACCTGCCACAGCCTCCCAAAGTGCTGGATTATAGGCGTGAGCACCTGGCCTCACATTTTCTATTTTCAATACTGTTTGCTTTAAAAAAAATTTTTTTTTTTAATTTTAGAACTGGGGTTTCACTATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCAATCCTGCCTCGGCCTCCAGGATTACTCTTTAAAATAATTAGAACAGCACCTTTTCCCTGATTTCCTTTGGGCACAACCAGGCCCTGACTCCCCACCAGGGGCAGCCCACGCAGGCTGCTGGGTGTCATCACTGTCCAGGGTCCCCACCCACCTGCATGCACTGGAACAGCAATGTCATGATGTTGCTGCGGGCCACCAGCTGCTCCACGTGACCACCCAGGCCCTCGGCCAGGCCGCTGAGCAGATCCAGTGCTACGATCATGAAGTCCTTGTCGGGAGCCTCATACTGCTCAGGGTGCTGGGTGTACATCTAGACACAGATGCCGACAGGGGCACGGGTAAGTGGAGCAGGCCCGAGGCAGGCCAATGCAGAAGCACAGGTGACGGGCCTAGGGTTGCTCACCATGGCCTGAGCCAGTGTCTTCTGCACCAGGGTGACACAGCGCTGGTAGACGGGCTCACAGTAAGGCAGGAAGCCACTCTGCAGGGCGGTGGCCACCGATGACAGACACTGGCAGGGAGGAAGGCAGGTGGGGAGAACTCAGGCAGGGTGGGCAGGATGGGTTTCGGGTGAGGGGCAGGAGCCCACTCACCTCCAGCAGGGGGAAGAGGTCCTTGTCTTCGTCCTTGAGCTCATTCCACTTCTGGATCAGTGGGGGCATCAGCTTCTGGATGTATTCCTGGAGAGGGAGCACGAAATGGGCGCTCCCTGGGTCGGGGTGGCAGACTGTGACTCAGGTACCTGTTGCCCGAGTGATGAGGCCTGAGCGCCTCACCGTGGCTCATGGGACCCTGAAAGGCCTGCCATCTGGCCAGACCTCGAGGCCTTCATTCTTCTCACCTGTCCAAGCACCGCCCGCCCCACCCCACCCCCCGGGAGCCTGGGTTACCACCTCCTGGTTCCCGAAGCACAGCACTTACCACGCTGTCTCATAACTGTCTTTCTCCCCCACTAGACTGGGAGCAGGGCGAGGGCGGGGCCGGGTCTGTCTGTCTGCCTGTCGAGGTCACGGCCACGTCCCTGGCGTGCAACACGGGGTTGCCACCAGGTCACTGGATGCCCAGGGGCACGGGGATCGGGAGGCGGGAGCCGCTCTGGGGTCTCACCGGCTGGTTGAGGTGGTGGCCTACAGAGTCGACCAGGGTGCCAATGGCGTCATAGAGGATGAGCAGGTTCTTGTGCTGGTATTTCCCAAAGGCAAAGACAAGGGTGTCCAGGATGTAGCTGAGGTAGGGCACCAGCTCCGTGCAGGCCTCTTCCTCCAGGGTGGCAAAAGCACTGGTGGGAGGGAGGATGAAGCGGGGGCTCAGTGGACCATGGCAGGTGACACTGGGCCATGGGCAGTTGGGGAGGGCAACTCAGGATCAGCCAGTACGAATACGCGATAAATCAGTTCCACATCAACAGTCACAGGTGTCATCACTTCCCAGAGGGTGGCCGGGGGAGAGTGGGGGCTGTGGGATCAGGGGTCCAGGGTCACCTGCAGGCCGCCTCCTGTACCCTCTTGTTGCCATCCAGGATGCGTTTGAGCAGCTCTGTCATCAGGGGCTTGAGGTGCATGTCGGGTGGCTGGCTGACCACCCAGTGGGCATAGCGGCTCAGCGTCCAGCAGGCGATGGAGCGGACCAAGGCCTTCTTATCCGACAGGCACTGGATCAGGTGCGGGATCAGCTCAGGCAGGTAGGGCACCATGCCCTGCATGCAGCCTACAAGGAAAGGGAACCAAGAGGGGGCAGTTTGATTGGGCCCAGCCACACCCACCGTATGGAGAGAAGAGTCAGCCGCACACAACATATAGGGAAACTGAGGCTTAGAGTTTAAATCACTGGCCCAGACTCATTTCACAGAGCCAGGTAAAGGCAGGCACAGGAGGGGAAACAACAGAAGCCTCTCATCCCAAAGCCCCGGGTTATCTTTATTTTTTTTTGAGGCAGAGTCTCGCTCTGTCGCCCAGGCTGGGGCGCAGTGGTACGATCATGGCTCACCGCAACCTTCACCTCCTGGTTCAAACAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCCTCTGCCACAATGCCCGGGGAATTTTTTATATTTTCAGTAGAGACAGGGTTTTACCATGTTGACCAAGATGGTCTCAGTCTCCTGACCTCGTGATCCACCCGCCCTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCAAAGAGCTCCGTGTTATTGCGTTAATTCAATTCATGCATTAATTCATGTGTTAATTGAATTCATGTGTTAATTCAAAATTGGCTCCGTTACATAGTGAGTGGGGTTTTATGGGGCAGCAGTGACCCAAATGGAATAAAAGCACTTTGCATTTGAAACAGTTCTTAAGATGTTTGTGAGTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTAGAGTGCAGTGGTGTGATCTGGGCTCACTGCAGCCTCTGCCTCCCGGGTTCAAGTGATTTCCTGCCTAAGCCTCCCAAGTAGCTGGGACTGCAGGCGCCCGCCACCATACCCAACTAATTTTTATATTTTTAGTAGAGACGGGGTTTTACCATGTTGGCTAGACTGGTCTTAAAATCCCGACCTCACGTGATCCCACCTCAGCCTCCCAGAGTGCTGCGATTATAGGTGTCTGGCCGTTTATGATTGTTCTATTTCTCCTTATTTTTGTTTAATTTTTTAATTTATTATTATTATTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAAGCTGAAGTACAGTTGCACAATCTTGGCTCACTGCAACCTCCGCCTCCCTGATTCAAGCAATTTTCCTGCCTCAACCTCCCCAGTAGCTGGGACTACAGGCGTGGGCCACCACGTGTGGCTAATTTTTCATATTTTTAGCAGAGACGAAGTTTCACCGTGTTAGCCAGGCTGGTCTCGAACTCCTGACCTCAGTTGATTCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCAGCCATTTTTAACAATTTTTTAATGTTTTCTTTGAGACAGAGTCTCGCTCTGTCCCCCAAGGAGGAGTGCAGTGGTGTGATCTCCACTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTGTCGTGCCTCAGCCTCCCAATAGCTAGGACTACAG
Task1_train_26559
Given a variant located on Chromosome 19 and affecting TNPO2 (transportin 2), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies
AGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGAAGGCGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACCCCAGCCTGGCGAGAAAGCAAGACTCAGTCTCAAATAAATAAATAAATAACACAGCTTATGTAATCTATTAACATATGTAAGCGTATTGTGTGATATATACCCTATTAACATGAGATATGAGATACATTAAACACATATTACATGTCGAAACATTTCTTTAGACAATTTTTTTTTGAGACAGGGTCTCAGTCTGTTCTCCATGCTGGAACGCAGTGGCGCAATCATGGCTCACTGCAGCCTTGACCTCTCACCTCAGCCTCCCAGTTAGTTGGGACTATAGGCACTTACCACCACGCCGGCTAATTTTATCAGGTTTTTTTTTTTTTTTTTTTTGGTAGATATGAGGTCTCACTATATTGCCCAGGCTGGTCTTGAACACCTGGGCTCAAACGATCTGCCTGCCTCAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACCACACCTGGCCTTTTTAAAAAATTTTTTGTAGAAAGAGGGTTTCCCTATGTTGCCCAGGCTGGTCTCGGACTCCTGGGCTAAAGCAGTTGTCCTGCTTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTGCACCACAGTAACTAGACAAATTTTAGACAAATTTTGAAAGCTTACAAGGTTGAGGGTTTTTGCTGCCATGCCTGAAATTTTTGGCACAGGTCTGGATGCTGAGGCAATGGTATATGATGCCTCCAACGGACTCACAAAGCCCTCCTGTAACAAGTTTTATGTCCCACCGGGACCATGGGAGCCTGAAAACCCCACCGATTACAGAACACCAGGTTGAATTTGATGAAACACCACCTACCACGGGTTACTACTGACTCTGGCAGGCCAGCCCGGCAGCCAGGAACAGGTTTAAGGCCCAGACACACCCTGAGTGACTGTAAGGAAGTGGCATCAATCTTTCTGTACCTCAGTTTCCCCATCTTCGAAACTGGGATCCGGCACCCAGCTCATCAGGTGGTGGTGAGGGCCAAGGATGTTTGTCTACATAAGTGCACGAGGCAAGCATGCAGCTGTGCCTGCTGTTATTATCATTGTTGCTGTAATTATGCTTACAACATGAAAGAACTACCTGCCTGCAAGAATGAACAAGAGGCCTTGCACTGTGGGGCTCCAGGGGTTCCTTTCAGGCCCAGGAACCAAGGGGAGAATTGAGATCTCAGAGCTGTTTGGAGTGGGGTGAGTAGGCCTCCAGGGAGAACTGAGGCATTGGTGTGGCTAGTAATGTGGGCCAGCCCTACAGTCTCATGCCAGCACAGGGCTCAGAGATCAGGCGCACTCACCCTCAGCAATGGCGCCCAGCACCAGGATGCCCGACTCCTTGACCACCCACTCGGGGTGGAAGAGGAGGCCTTTGAGTAGTGGGAGTAGGTGGGGCAGCAGTTCCTCCCGGAAGACATTGGCGAGGACGTCCAGTGCAGCCGCTGAGCACTTCCCTGGGGAAGGGGGAACAATGGGGAGGCTCAGGGCGGCCCCTCAGGCAGGTGGCCGACCCTCCTTGACTGCACTCCCAGGATCAGAGATCATGCTCAGAATCTTCACGATCAGCTTCTTTTTTTTTGTTTTGTTTTTTTGAGACGGAGTCTCACTTTTTCCGCCCAGGCCGGAGTGCAGTGGCGCTATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCATGCCGTTTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGACACCACGCCCGACTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTGTTGATCTCCTGACCTCGTGATCCGCCCGCCTCAGCCTTCCAAAGTGCTGGGATTACAGGCGTAAGCCACTGCGCCCGGCCACGATCAGCTTCTAATCAGCTTCTGCCTCAGCTTCTAGTCACCTCCCAAGAGGGAGTCCAGGGCTTGCCACCCCACCACCACCCCCAGGCAGGGGCACACACTCAAATTCCAGTCGGACAGAGCATCATCATCATCGTCATCCTCCGCGTCCTCGGAGCCATCAGGCCGCTCAGCCTCGTGGGGCAGTGTGACCGTGCGTGACTTGTGGAAGCGTGGCTTGATGTCCTGCTCACTGTCGGGGACAGCCTCATCCTCCTCCACATCCCCCTGGGGGACAGGCAGACTGTTAAGTACTTTGGGGACCACAGCCGCGACACCCACGCCCATGCCCACCCATGCTGGGTGGGCCCTGCCTGACCTTGAGCAGGATGATGTCAATTTCCGAGTACTTCATCCCATTCACCAAGATGGGGATCAACCTGCACAGAGAGGGACTGTTTATGGGGATGCAGGGGCCGTGGCAAAAGTTGGGGGGAGGCACAGCTTGGGGAGGAGGCAAACAGGTGCCAACAGAGTGACCAGCCCCCCAATCAGCCACAGAGCAGACCCTGCAGAGCATGATGGTACTGCTAGGTGCAAATTGATCCATTTCCCTCTGGGGAATTATCGGAATCTAGTCTCTGCCGCTATGATTAGGATATAAATGATACCACTCCTGCCTCCAGAGAAAGGTTTTTTTTTTTTTTTCTTAAGAAGCAGGGTCTAACCCTGTGGGCGGCAAGCCACCCAGGCACCGAGGCAAGAGACAGAGGACACGAGCTGTTCCAGTATAATAAAATATAAAACAAGAATAGTTATACCAGATATAGATCTTAGATATGATTATATATGAATATCATTAATCATTAGTTTGTAGCAATTACTTTTTATTCCAATATTATGATAATCCTCGCTCTATAATCATAGCCTAGGAAAAACCAGGCCATACAGAGATAGGAGCTGAGGGGACATAGTGAGGTGTGACCAGAAGACAAGAGTGCGAGCCTTCTGTTATGCCCGGACAGGGCCACCAGAGGGCTCCTTGGTCTAGCGGTGACGCCAGCATCTGGGAAGACGCCCGTTACCAGGCGGATCATGGTCCAGCGGTAGCAAAAGGTGTCAAGGAACAACACCCGCTACTTAGCAGACCAGGAAAGTGGGGGAGTCTCCCTTTCCCCGGGGGAGTTTAGAGAAGACTCTGCTCCTCCACCTCTTGTGGAGGGCCTGACATCAGTCAGGTTTGCCCGCAGTTATCCGGAGGCCTAACCGTCTCCCTGAGATGCTGTGCTTCAGTGGTCACACTCCTAGTCTGCCTTCATGTTCCATCCTGTACACCTGGCTCTGCCTTCCAGATAGCAGTAGTAAATTAGTGAAAATACTAATAGTCCCTGATATGCAGAAATAATGGCATACGCTGTCTTTCTCTTTGTCTACTCTCCCTCTCTGCCTCGGCTGCCAGGCAGGGAAGGGCCCCCTGTCCAGTGGACACGTGACCCATGTGACCTTACCTATCATTGGAGGTGACTCACATTCTTTACCCTGCCCCTTCTGCCTTGTATGCAATAAATAACAGCGCAGCCAGACATTTGGGGTCACTACCGGTCTCCGCGCATTGGTGGTAGTGGTCCCCCGGGCCCAGCTGCCTTTTCTATTATCTCTTTGTCTTGTGTCTTTATTTCTACACTCTCTCATCGCCGCACACAGGAAGAGACCCACCGACCCTGTGGGGCTGGTCCCTACGTAACCCTATCACCCAGGCTGGAGTGCACTGGTGCGATCACAGCTCACCACAGCCTCATGCTCCTGGGCTCATGCAATCCTCCTGCCTCAGCCTCCCAAAGTGCTAGGATTATAGGCGTGAGCCATGGCACTCAGCCTGCAGGAAAGCTCTTGACCCAGGCCTGGCCACTCAGTGGATTATAGACCCCTGAATACACTGAAAATCTTGGTACAGTGCCTGGTCCCTAGCACAACATTAAGGCAGGGACATGCGGTCCTATTCCTGGCCACTTTCCTGAGATAGGGCAGAGACTAGCCAGAGTAGGGGAGCAAACAGACTAGGCAGCCAGCCCCTCAGCTGCAGCCCAGAGTTGTAAGTGACAGAGCCTTCATCACCTGCTCATCTAGGTCTCATCACTCCCCAGGAGCCGTCTGCCCAGCCCTAGACTGTTATCAAT
AGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGAAGGCGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACCCCAGCCTGGCGAGAAAGCAAGACTCAGTCTCAAATAAATAAATAAATAACACAGCTTATGTAATCTATTAACATATGTAAGCGTATTGTGTGATATATACCCTATTAACATGAGATATGAGATACATTAAACACATATTACATGTCGAAACATTTCTTTAGACAATTTTTTTTTGAGACAGGGTCTCAGTCTGTTCTCCATGCTGGAACGCAGTGGCGCAATCATGGCTCACTGCAGCCTTGACCTCTCACCTCAGCCTCCCAGTTAGTTGGGACTATAGGCACTTACCACCACGCCGGCTAATTTTATCAGGTTTTTTTTTTTTTTTTTTTTGGTAGATATGAGGTCTCACTATATTGCCCAGGCTGGTCTTGAACACCTGGGCTCAAACGATCTGCCTGCCTCAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACCACACCTGGCCTTTTTAAAAAATTTTTTGTAGAAAGAGGGTTTCCCTATGTTGCCCAGGCTGGTCTCGGACTCCTGGGCTAAAGCAGTTGTCCTGCTTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTGCACCACAGTAACTAGACAAATTTTAGACAAATTTTGAAAGCTTACAAGGTTGAGGGTTTTTGCTGCCATGCCTGAAATTTTTGGCACAGGTCTGGATGCTGAGGCAATGGTATATGATGCCTCCAACGGACTCACAAAGCCCTCCTGTAACAAGTTTTATGTCCCACCGGGACCATGGGAGCCTGAAAACCCCACCGATTACAGAACACCAGGTTGAATTTGATGAAACACCACCTACCACGGGTTACTACTGACTCTGGCAGGCCAGCCCGGCAGCCAGGAACAGGTTTAAGGCCCAGACACACCCTGAGTGACTGTAAGGAAGTGGCATCAATCTTTCTGTACCTCAGTTTCCCCATCTTCGAAACTGGGATCCGGCACCCAGCTCATCAGGTGGTGGTGAGGGCCAAGGATGTTTGTCTACATAAGTGCACGAGGCAAGCATGCAGCTGTGCCTGCTGTTATTATCATTGTTGCTGTAATTATGCTTACAACATGAAAGAACTACCTGCCTGCAAGAATGAACAAGAGGCCTTGCACTGTGGGGCTCCAGGGGTTCCTTTCAGGCCCAGGAACCAAGGGGAGAATTGAGATCTCAGAGCTGTTTGGAGTGGGGTGAGTAGGCCTCCAGGGAGAACTGAGGCATTGGTGTGGCTAGTAATGTGGGCCAGCCCTACAGTCTCATGCCAGCACAGGGCTCAGAGATCAGGCGCACTCACCCTCAGCAATGGCGCCCAGCACCAGGATGCCCGACTCCTTGACCACCCACTCGGGGTGGAAGAGGAGGCCTTTGAGTAGTGGGAGTAGGTGGGGCAGCAGTTCCTCCCGGAAGACATTGGCGAGGACGTCCAGTGCAGCCGCTGAGCACTTCCCTGGGGAAGGGGGAACAATGGGGAGGCTCAGGGCGGCCCCTCAGGCAGGTGGCCGACCCTCCTTGACTGCACTCCCAGGATCAGAGATCATGCTCAGAATCTTCACGATCAGCTTCTTTTTTTTTGTTTTGTTTTTTTGAGACGGAGTCTCACTTTTTCCGCCCAGGCCGGAGTGCAGTGGCGCTATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCATGCCGTTTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGACACCACGCCCGACTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTGTTGATCTCCTGACCTCGTGATCCGCCCGCCTCAGCCTTCCAAAGTGCTGGGATTACAGGCGTAAGCCACTGCGCCCGGCCACGATCAGCTTCTAATCAGCTTCTGCCTCAGCTTCTAGTCACCTCCCAAGAGGGAGTCCAGGGCTTGCCACCCCACCACCACCCCCAGGCAGGGGCACACACTCAAATTGCAGTCGGACAGAGCATCATCATCATCGTCATCCTCCGCGTCCTCGGAGCCATCAGGCCGCTCAGCCTCGTGGGGCAGTGTGACCGTGCGTGACTTGTGGAAGCGTGGCTTGATGTCCTGCTCACTGTCGGGGACAGCCTCATCCTCCTCCACATCCCCCTGGGGGACAGGCAGACTGTTAAGTACTTTGGGGACCACAGCCGCGACACCCACGCCCATGCCCACCCATGCTGGGTGGGCCCTGCCTGACCTTGAGCAGGATGATGTCAATTTCCGAGTACTTCATCCCATTCACCAAGATGGGGATCAACCTGCACAGAGAGGGACTGTTTATGGGGATGCAGGGGCCGTGGCAAAAGTTGGGGGGAGGCACAGCTTGGGGAGGAGGCAAACAGGTGCCAACAGAGTGACCAGCCCCCCAATCAGCCACAGAGCAGACCCTGCAGAGCATGATGGTACTGCTAGGTGCAAATTGATCCATTTCCCTCTGGGGAATTATCGGAATCTAGTCTCTGCCGCTATGATTAGGATATAAATGATACCACTCCTGCCTCCAGAGAAAGGTTTTTTTTTTTTTTTCTTAAGAAGCAGGGTCTAACCCTGTGGGCGGCAAGCCACCCAGGCACCGAGGCAAGAGACAGAGGACACGAGCTGTTCCAGTATAATAAAATATAAAACAAGAATAGTTATACCAGATATAGATCTTAGATATGATTATATATGAATATCATTAATCATTAGTTTGTAGCAATTACTTTTTATTCCAATATTATGATAATCCTCGCTCTATAATCATAGCCTAGGAAAAACCAGGCCATACAGAGATAGGAGCTGAGGGGACATAGTGAGGTGTGACCAGAAGACAAGAGTGCGAGCCTTCTGTTATGCCCGGACAGGGCCACCAGAGGGCTCCTTGGTCTAGCGGTGACGCCAGCATCTGGGAAGACGCCCGTTACCAGGCGGATCATGGTCCAGCGGTAGCAAAAGGTGTCAAGGAACAACACCCGCTACTTAGCAGACCAGGAAAGTGGGGGAGTCTCCCTTTCCCCGGGGGAGTTTAGAGAAGACTCTGCTCCTCCACCTCTTGTGGAGGGCCTGACATCAGTCAGGTTTGCCCGCAGTTATCCGGAGGCCTAACCGTCTCCCTGAGATGCTGTGCTTCAGTGGTCACACTCCTAGTCTGCCTTCATGTTCCATCCTGTACACCTGGCTCTGCCTTCCAGATAGCAGTAGTAAATTAGTGAAAATACTAATAGTCCCTGATATGCAGAAATAATGGCATACGCTGTCTTTCTCTTTGTCTACTCTCCCTCTCTGCCTCGGCTGCCAGGCAGGGAAGGGCCCCCTGTCCAGTGGACACGTGACCCATGTGACCTTACCTATCATTGGAGGTGACTCACATTCTTTACCCTGCCCCTTCTGCCTTGTATGCAATAAATAACAGCGCAGCCAGACATTTGGGGTCACTACCGGTCTCCGCGCATTGGTGGTAGTGGTCCCCCGGGCCCAGCTGCCTTTTCTATTATCTCTTTGTCTTGTGTCTTTATTTCTACACTCTCTCATCGCCGCACACAGGAAGAGACCCACCGACCCTGTGGGGCTGGTCCCTACGTAACCCTATCACCCAGGCTGGAGTGCACTGGTGCGATCACAGCTCACCACAGCCTCATGCTCCTGGGCTCATGCAATCCTCCTGCCTCAGCCTCCCAAAGTGCTAGGATTATAGGCGTGAGCCATGGCACTCAGCCTGCAGGAAAGCTCTTGACCCAGGCCTGGCCACTCAGTGGATTATAGACCCCTGAATACACTGAAAATCTTGGTACAGTGCCTGGTCCCTAGCACAACATTAAGGCAGGGACATGCGGTCCTATTCCTGGCCACTTTCCTGAGATAGGGCAGAGACTAGCCAGAGTAGGGGAGCAAACAGACTAGGCAGCCAGCCCCTCAGCTGCAGCCCAGAGTTGTAAGTGACAGAGCCTTCATCACCTGCTCATCTAGGTCTCATCACTCCCCAGGAGCCGTCTGCCCAGCCCTAGACTGTTATCAAT
Task1_train_26560
The gene TNPO2 (transportin 2) on Chromosome 19 contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies
GAGGCTGAGGCAGGAGAATCACTTGAACCTGGAAGGCGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACCCCAGCCTGGCGAGAAAGCAAGACTCAGTCTCAAATAAATAAATAAATAACACAGCTTATGTAATCTATTAACATATGTAAGCGTATTGTGTGATATATACCCTATTAACATGAGATATGAGATACATTAAACACATATTACATGTCGAAACATTTCTTTAGACAATTTTTTTTTGAGACAGGGTCTCAGTCTGTTCTCCATGCTGGAACGCAGTGGCGCAATCATGGCTCACTGCAGCCTTGACCTCTCACCTCAGCCTCCCAGTTAGTTGGGACTATAGGCACTTACCACCACGCCGGCTAATTTTATCAGGTTTTTTTTTTTTTTTTTTTTGGTAGATATGAGGTCTCACTATATTGCCCAGGCTGGTCTTGAACACCTGGGCTCAAACGATCTGCCTGCCTCAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACCACACCTGGCCTTTTTAAAAAATTTTTTGTAGAAAGAGGGTTTCCCTATGTTGCCCAGGCTGGTCTCGGACTCCTGGGCTAAAGCAGTTGTCCTGCTTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTGCACCACAGTAACTAGACAAATTTTAGACAAATTTTGAAAGCTTACAAGGTTGAGGGTTTTTGCTGCCATGCCTGAAATTTTTGGCACAGGTCTGGATGCTGAGGCAATGGTATATGATGCCTCCAACGGACTCACAAAGCCCTCCTGTAACAAGTTTTATGTCCCACCGGGACCATGGGAGCCTGAAAACCCCACCGATTACAGAACACCAGGTTGAATTTGATGAAACACCACCTACCACGGGTTACTACTGACTCTGGCAGGCCAGCCCGGCAGCCAGGAACAGGTTTAAGGCCCAGACACACCCTGAGTGACTGTAAGGAAGTGGCATCAATCTTTCTGTACCTCAGTTTCCCCATCTTCGAAACTGGGATCCGGCACCCAGCTCATCAGGTGGTGGTGAGGGCCAAGGATGTTTGTCTACATAAGTGCACGAGGCAAGCATGCAGCTGTGCCTGCTGTTATTATCATTGTTGCTGTAATTATGCTTACAACATGAAAGAACTACCTGCCTGCAAGAATGAACAAGAGGCCTTGCACTGTGGGGCTCCAGGGGTTCCTTTCAGGCCCAGGAACCAAGGGGAGAATTGAGATCTCAGAGCTGTTTGGAGTGGGGTGAGTAGGCCTCCAGGGAGAACTGAGGCATTGGTGTGGCTAGTAATGTGGGCCAGCCCTACAGTCTCATGCCAGCACAGGGCTCAGAGATCAGGCGCACTCACCCTCAGCAATGGCGCCCAGCACCAGGATGCCCGACTCCTTGACCACCCACTCGGGGTGGAAGAGGAGGCCTTTGAGTAGTGGGAGTAGGTGGGGCAGCAGTTCCTCCCGGAAGACATTGGCGAGGACGTCCAGTGCAGCCGCTGAGCACTTCCCTGGGGAAGGGGGAACAATGGGGAGGCTCAGGGCGGCCCCTCAGGCAGGTGGCCGACCCTCCTTGACTGCACTCCCAGGATCAGAGATCATGCTCAGAATCTTCACGATCAGCTTCTTTTTTTTTGTTTTGTTTTTTTGAGACGGAGTCTCACTTTTTCCGCCCAGGCCGGAGTGCAGTGGCGCTATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCATGCCGTTTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGACACCACGCCCGACTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTGTTGATCTCCTGACCTCGTGATCCGCCCGCCTCAGCCTTCCAAAGTGCTGGGATTACAGGCGTAAGCCACTGCGCCCGGCCACGATCAGCTTCTAATCAGCTTCTGCCTCAGCTTCTAGTCACCTCCCAAGAGGGAGTCCAGGGCTTGCCACCCCACCACCACCCCCAGGCAGGGGCACACACTCAAATTCCAGTCGGACAGAGCATCATCATCATCGTCATCCTCCGCGTCCTCGGAGCCATCAGGCCGCTCAGCCTCGTGGGGCAGTGTGACCGTGCGTGACTTGTGGAAGCGTGGCTTGATGTCCTGCTCACTGTCGGGGACAGCCTCATCCTCCTCCACATCCCCCTGGGGGACAGGCAGACTGTTAAGTACTTTGGGGACCACAGCCGCGACACCCACGCCCATGCCCACCCATGCTGGGTGGGCCCTGCCTGACCTTGAGCAGGATGATGTCAATTTCCGAGTACTTCATCCCATTCACCAAGATGGGGATCAACCTGCACAGAGAGGGACTGTTTATGGGGATGCAGGGGCCGTGGCAAAAGTTGGGGGGAGGCACAGCTTGGGGAGGAGGCAAACAGGTGCCAACAGAGTGACCAGCCCCCCAATCAGCCACAGAGCAGACCCTGCAGAGCATGATGGTACTGCTAGGTGCAAATTGATCCATTTCCCTCTGGGGAATTATCGGAATCTAGTCTCTGCCGCTATGATTAGGATATAAATGATACCACTCCTGCCTCCAGAGAAAGGTTTTTTTTTTTTTTTCTTAAGAAGCAGGGTCTAACCCTGTGGGCGGCAAGCCACCCAGGCACCGAGGCAAGAGACAGAGGACACGAGCTGTTCCAGTATAATAAAATATAAAACAAGAATAGTTATACCAGATATAGATCTTAGATATGATTATATATGAATATCATTAATCATTAGTTTGTAGCAATTACTTTTTATTCCAATATTATGATAATCCTCGCTCTATAATCATAGCCTAGGAAAAACCAGGCCATACAGAGATAGGAGCTGAGGGGACATAGTGAGGTGTGACCAGAAGACAAGAGTGCGAGCCTTCTGTTATGCCCGGACAGGGCCACCAGAGGGCTCCTTGGTCTAGCGGTGACGCCAGCATCTGGGAAGACGCCCGTTACCAGGCGGATCATGGTCCAGCGGTAGCAAAAGGTGTCAAGGAACAACACCCGCTACTTAGCAGACCAGGAAAGTGGGGGAGTCTCCCTTTCCCCGGGGGAGTTTAGAGAAGACTCTGCTCCTCCACCTCTTGTGGAGGGCCTGACATCAGTCAGGTTTGCCCGCAGTTATCCGGAGGCCTAACCGTCTCCCTGAGATGCTGTGCTTCAGTGGTCACACTCCTAGTCTGCCTTCATGTTCCATCCTGTACACCTGGCTCTGCCTTCCAGATAGCAGTAGTAAATTAGTGAAAATACTAATAGTCCCTGATATGCAGAAATAATGGCATACGCTGTCTTTCTCTTTGTCTACTCTCCCTCTCTGCCTCGGCTGCCAGGCAGGGAAGGGCCCCCTGTCCAGTGGACACGTGACCCATGTGACCTTACCTATCATTGGAGGTGACTCACATTCTTTACCCTGCCCCTTCTGCCTTGTATGCAATAAATAACAGCGCAGCCAGACATTTGGGGTCACTACCGGTCTCCGCGCATTGGTGGTAGTGGTCCCCCGGGCCCAGCTGCCTTTTCTATTATCTCTTTGTCTTGTGTCTTTATTTCTACACTCTCTCATCGCCGCACACAGGAAGAGACCCACCGACCCTGTGGGGCTGGTCCCTACGTAACCCTATCACCCAGGCTGGAGTGCACTGGTGCGATCACAGCTCACCACAGCCTCATGCTCCTGGGCTCATGCAATCCTCCTGCCTCAGCCTCCCAAAGTGCTAGGATTATAGGCGTGAGCCATGGCACTCAGCCTGCAGGAAAGCTCTTGACCCAGGCCTGGCCACTCAGTGGATTATAGACCCCTGAATACACTGAAAATCTTGGTACAGTGCCTGGTCCCTAGCACAACATTAAGGCAGGGACATGCGGTCCTATTCCTGGCCACTTTCCTGAGATAGGGCAGAGACTAGCCAGAGTAGGGGAGCAAACAGACTAGGCAGCCAGCCCCTCAGCTGCAGCCCAGAGTTGTAAGTGACAGAGCCTTCATCACCTGCTCATCTAGGTCTCATCACTCCCCAGGAGCCGTCTGCCCAGCCCTAGACTGTTATCAATAA
GAGGCTGAGGCAGGAGAATCACTTGAACCTGGAAGGCGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACCCCAGCCTGGCGAGAAAGCAAGACTCAGTCTCAAATAAATAAATAAATAACACAGCTTATGTAATCTATTAACATATGTAAGCGTATTGTGTGATATATACCCTATTAACATGAGATATGAGATACATTAAACACATATTACATGTCGAAACATTTCTTTAGACAATTTTTTTTTGAGACAGGGTCTCAGTCTGTTCTCCATGCTGGAACGCAGTGGCGCAATCATGGCTCACTGCAGCCTTGACCTCTCACCTCAGCCTCCCAGTTAGTTGGGACTATAGGCACTTACCACCACGCCGGCTAATTTTATCAGGTTTTTTTTTTTTTTTTTTTTGGTAGATATGAGGTCTCACTATATTGCCCAGGCTGGTCTTGAACACCTGGGCTCAAACGATCTGCCTGCCTCAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACCACACCTGGCCTTTTTAAAAAATTTTTTGTAGAAAGAGGGTTTCCCTATGTTGCCCAGGCTGGTCTCGGACTCCTGGGCTAAAGCAGTTGTCCTGCTTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTGCACCACAGTAACTAGACAAATTTTAGACAAATTTTGAAAGCTTACAAGGTTGAGGGTTTTTGCTGCCATGCCTGAAATTTTTGGCACAGGTCTGGATGCTGAGGCAATGGTATATGATGCCTCCAACGGACTCACAAAGCCCTCCTGTAACAAGTTTTATGTCCCACCGGGACCATGGGAGCCTGAAAACCCCACCGATTACAGAACACCAGGTTGAATTTGATGAAACACCACCTACCACGGGTTACTACTGACTCTGGCAGGCCAGCCCGGCAGCCAGGAACAGGTTTAAGGCCCAGACACACCCTGAGTGACTGTAAGGAAGTGGCATCAATCTTTCTGTACCTCAGTTTCCCCATCTTCGAAACTGGGATCCGGCACCCAGCTCATCAGGTGGTGGTGAGGGCCAAGGATGTTTGTCTACATAAGTGCACGAGGCAAGCATGCAGCTGTGCCTGCTGTTATTATCATTGTTGCTGTAATTATGCTTACAACATGAAAGAACTACCTGCCTGCAAGAATGAACAAGAGGCCTTGCACTGTGGGGCTCCAGGGGTTCCTTTCAGGCCCAGGAACCAAGGGGAGAATTGAGATCTCAGAGCTGTTTGGAGTGGGGTGAGTAGGCCTCCAGGGAGAACTGAGGCATTGGTGTGGCTAGTAATGTGGGCCAGCCCTACAGTCTCATGCCAGCACAGGGCTCAGAGATCAGGCGCACTCACCCTCAGCAATGGCGCCCAGCACCAGGATGCCCGACTCCTTGACCACCCACTCGGGGTGGAAGAGGAGGCCTTTGAGTAGTGGGAGTAGGTGGGGCAGCAGTTCCTCCCGGAAGACATTGGCGAGGACGTCCAGTGCAGCCGCTGAGCACTTCCCTGGGGAAGGGGGAACAATGGGGAGGCTCAGGGCGGCCCCTCAGGCAGGTGGCCGACCCTCCTTGACTGCACTCCCAGGATCAGAGATCATGCTCAGAATCTTCACGATCAGCTTCTTTTTTTTTGTTTTGTTTTTTTGAGACGGAGTCTCACTTTTTCCGCCCAGGCCGGAGTGCAGTGGCGCTATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCATGCCGTTTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGACACCACGCCCGACTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTGTTGATCTCCTGACCTCGTGATCCGCCCGCCTCAGCCTTCCAAAGTGCTGGGATTACAGGCGTAAGCCACTGCGCCCGGCCACGATCAGCTTCTAATCAGCTTCTGCCTCAGCTTCTAGTCACCTCCCAAGAGGGAGTCCAGGGCTTGCCACCCCACCACCACCCCCAGGCAGGGGCACACACTCAAATTCCGGTCGGACAGAGCATCATCATCATCGTCATCCTCCGCGTCCTCGGAGCCATCAGGCCGCTCAGCCTCGTGGGGCAGTGTGACCGTGCGTGACTTGTGGAAGCGTGGCTTGATGTCCTGCTCACTGTCGGGGACAGCCTCATCCTCCTCCACATCCCCCTGGGGGACAGGCAGACTGTTAAGTACTTTGGGGACCACAGCCGCGACACCCACGCCCATGCCCACCCATGCTGGGTGGGCCCTGCCTGACCTTGAGCAGGATGATGTCAATTTCCGAGTACTTCATCCCATTCACCAAGATGGGGATCAACCTGCACAGAGAGGGACTGTTTATGGGGATGCAGGGGCCGTGGCAAAAGTTGGGGGGAGGCACAGCTTGGGGAGGAGGCAAACAGGTGCCAACAGAGTGACCAGCCCCCCAATCAGCCACAGAGCAGACCCTGCAGAGCATGATGGTACTGCTAGGTGCAAATTGATCCATTTCCCTCTGGGGAATTATCGGAATCTAGTCTCTGCCGCTATGATTAGGATATAAATGATACCACTCCTGCCTCCAGAGAAAGGTTTTTTTTTTTTTTTCTTAAGAAGCAGGGTCTAACCCTGTGGGCGGCAAGCCACCCAGGCACCGAGGCAAGAGACAGAGGACACGAGCTGTTCCAGTATAATAAAATATAAAACAAGAATAGTTATACCAGATATAGATCTTAGATATGATTATATATGAATATCATTAATCATTAGTTTGTAGCAATTACTTTTTATTCCAATATTATGATAATCCTCGCTCTATAATCATAGCCTAGGAAAAACCAGGCCATACAGAGATAGGAGCTGAGGGGACATAGTGAGGTGTGACCAGAAGACAAGAGTGCGAGCCTTCTGTTATGCCCGGACAGGGCCACCAGAGGGCTCCTTGGTCTAGCGGTGACGCCAGCATCTGGGAAGACGCCCGTTACCAGGCGGATCATGGTCCAGCGGTAGCAAAAGGTGTCAAGGAACAACACCCGCTACTTAGCAGACCAGGAAAGTGGGGGAGTCTCCCTTTCCCCGGGGGAGTTTAGAGAAGACTCTGCTCCTCCACCTCTTGTGGAGGGCCTGACATCAGTCAGGTTTGCCCGCAGTTATCCGGAGGCCTAACCGTCTCCCTGAGATGCTGTGCTTCAGTGGTCACACTCCTAGTCTGCCTTCATGTTCCATCCTGTACACCTGGCTCTGCCTTCCAGATAGCAGTAGTAAATTAGTGAAAATACTAATAGTCCCTGATATGCAGAAATAATGGCATACGCTGTCTTTCTCTTTGTCTACTCTCCCTCTCTGCCTCGGCTGCCAGGCAGGGAAGGGCCCCCTGTCCAGTGGACACGTGACCCATGTGACCTTACCTATCATTGGAGGTGACTCACATTCTTTACCCTGCCCCTTCTGCCTTGTATGCAATAAATAACAGCGCAGCCAGACATTTGGGGTCACTACCGGTCTCCGCGCATTGGTGGTAGTGGTCCCCCGGGCCCAGCTGCCTTTTCTATTATCTCTTTGTCTTGTGTCTTTATTTCTACACTCTCTCATCGCCGCACACAGGAAGAGACCCACCGACCCTGTGGGGCTGGTCCCTACGTAACCCTATCACCCAGGCTGGAGTGCACTGGTGCGATCACAGCTCACCACAGCCTCATGCTCCTGGGCTCATGCAATCCTCCTGCCTCAGCCTCCCAAAGTGCTAGGATTATAGGCGTGAGCCATGGCACTCAGCCTGCAGGAAAGCTCTTGACCCAGGCCTGGCCACTCAGTGGATTATAGACCCCTGAATACACTGAAAATCTTGGTACAGTGCCTGGTCCCTAGCACAACATTAAGGCAGGGACATGCGGTCCTATTCCTGGCCACTTTCCTGAGATAGGGCAGAGACTAGCCAGAGTAGGGGAGCAAACAGACTAGGCAGCCAGCCCCTCAGCTGCAGCCCAGAGTTGTAAGTGACAGAGCCTTCATCACCTGCTCATCTAGGTCTCATCACTCCCCAGGAGCCGTCTGCCCAGCCCTAGACTGTTATCAATAA
Task1_train_26561
This alteration in TNPO2 (transportin 2) on Chromosome 19 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; TNPO2-related disorder
TAGTGAGACCTCACCTCTAATGAATGATAAATAAATAAATAAATAAATAAATAAATAAATAAACATACAATATGCTGGGCGTGGTGACTCACGCCTGTAATCCTAGCACTTTGGGAGGCCAAAGTGGGCAGAACACAAGGTCAGGAAGCTGAGGCAAGAGAATCGCTTGAACCCGAGGGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCCCTCCAGCCTGGGCAGCAGAGTGAGACTCCGTCTCAAAAACAGAAATTTCAAAATAATAATAATAATGATCTGGGGGCTGGGTACAGTGGCTCGCACCTGTAATCTCAACACTTTAGGAGACCAAGACAGGAGGACTGCTTGAGGCCAGGGATCCGAGACCAGCCAGAGCAACTTAGCAAGACCTCATCTCTACTAAAACTTAGAAAAGATTAGCTAGGTGTGGTGGGATGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGTAGGAGGATTGCTTCAGCTGGGAGGTCAAGGCTGCAGTGAGCCATGATTTTGACACTCCACTCCAGCGTGGATGACAGAGCAAAACCTTGTCTCAAAATAAAAAAGAAAAAAATGATTTGGAGAGAGGCAAGCAATCCAAGTTTGTCAAGGAGGGTCAGTTTTAGGACTTTTGTTGGAAACACTGGTCGAAAATTTCTTTACTCTGAAGTTCCTAAGCTGGAAGGGCACAGAAGGCTACAGCACTACCCAGAGGGAAGGTTGTGCCTAAGAATGAAGCCAACACAAGGGAAGCAGATCTGAGACCACAAAGATGCCTTTCACATCCTTTGAGCTCCTGGATACAGCCATACCCCTGAAGCCTTTGTTGATTTTTCATTTCTTTTTTTTTTTTTTTTGAGACGGAGTTTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGACCTTGGCTCACTACAACCTCAGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCACCCTCCCAAGCAGCTGGGACTACAGGCGCCTGCCACCACGCCCAGCTATTTTTTTATATTTTTAGTAGAAATGGGGTTTCACCGTGTTAGCCAGGCTGGTCTCGATCTTCTGACCTTGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGTGTCAGCCACCACATGTGGCCATTGATTTTTCATTTCTTTCCACCTATCAGTTACCTAATTTTGAAGTCTTCAAAAAGTGGCATTCTTACCACTTACACATAAATATATACTGAATGTAAACTGACAAGGATGTGGACTGAGAGAAGCACAGCAGGTGACCAGAAGGGAAGGCAGAGGCATAGCAAGGGGTCGAAGCTGGGGTAGGACAGTGGGCAGCAGCAGCACTCACTGGACCAGATGGGAGGCCAGGACTTCCTTGCAGATGGGCTGCTCGGCCAGCGTCAGCCAGAACTCACAGGCCTCAAGGGCAACGTTCTCATCATGGTCCTGGGTCCTCTGCAGCATGTACTGTGGTAGGGGGGAGAAGCTGAGGCCTGGCCTGGCTGGGGGTGGCTCCCTGACCCCTGCCACCGGCCCCCTGCCTGCCCGCCTGGGCTGGCCTTGACCATGCACACCTGGATGATGCTGTGCATGTGGGGGATGAGCCTGTCAATCCGCACTTCCAGAAGCATCACCAGGGCACGGCACACATTCTTCCGCACCTCGGGGTCATCATCCACAGCCAGGGCAAATAGGTGCTGCAGGGAGGAACAGGGTCAGTTGTAGGGGCCCTCAGTCCTCGCCCTGCCCACCCCCAGCCCAGCGGCCCACCTCGATGAAGGTGTCAATATTGTCCATCAGCGCCTGGGCCCGGTCCATGATGAACTGGTTCACGCAGGCGATGGCGTGGGACCTGGCGGGGAGCAGACACGTGGGTCACCCTGACCCTGCCCACTCCAGGCTCCCTGGAAGCCCCCAGGGAGCTGCACCCACCGGATCTTGGGACTGCAGTGCTTGAAGAACTGCAGGAACTTGGGGATCATGATGTTGAGGGGCCTGTTGAGGGCGTCACTGTCCAGAAGCTCTGATGAGTCTTCACAGATCTTCTGCAGGGCTCCAAAGGCTCCCTGAGTGCAGAGGGGCAGAGAGACAAACGTGGGTGGTGGGTGGTGGTCCCAGCCCCCCAGTACTCGCTCTGGCCATCCATGGCTTCTTGCCTACCTCACAAGTGTTGTAATCCTCCGAGTTAAGCAGGTTGCAGAGCTGGGGCAGCAGCTCGGGCCACATCTGCAGCTCACCCTTGGAAGCGATGGTGGTGATGAGAATGCCTGGGGCGGCCGGGAAAGGACGCTGCCTGAGGCTGGGCAGGGGCTGCCTAGCACCTCCCCCTCCCACTGGACACCCCCAGTGCTGCCTTTCTGTTCCCTAGCCCATGTACGCCCTCTACATCCCCCCTCCTTTTTTTTTTCTTTGTAAGAGATAGAATTAGCTCTGTTGCCCAGGCTGGACTGCTGTGGCACAATCAATAGTCCACAGCAGCCTCAAACTCCTGGCCTCAAGCCATCTTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTGCAGGCACATGCCACCACGCCCAACTAATTTTTAAAATTGTTTGTAGAGATGGGATCTCACTATGTTGCCCAGGCTGGCCTAAAACTCCTGGCCTCAAGCAATCCTCCTGCCTTGGCCTCCAAAAGCACTGAGATTACAGGCGTGAGCCACCGCTCCTGGCCTTGACATAGGTAGAAGGGTACTCCTTGACTCAGTAGGCACCCTGAGCCTTACTGTGAGTCAACTCTGTTCCAGGCCCTGAGGCACAGCACAGAGCAAAACACAAAATCCTCACCCTTGGGAGCTGGAAGCAAGCTATGAAGTAAAGATAAATTAGCAAAAAAAACTGGGAGGGGCCGTGCATGGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGGGACCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGGGGGCACCAGTAATCCCAGCTACTTGGGAGGCCGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCAGAGATCGCGCCACAGCACTCCAGCCTGGGATGGAGCAAGACTCCATTTCAAAAACAAACAAAACAAAAACAAACAACTGGGAGGGGCCACATGCCAAGGACTAAGGGGGGAAATACAGCAGAAAAGATGGTGAGAAAGGGCTGTAGGTGAAGGTAGCAACTTTAAATTGGGTGGCCAGAGCAGGCCTCGTTGAGGTGACATCTTGATATCTGAGCCAAGGCCTGAAGGAGGTGAAGGAGGCGAGGGAGGAATCATCCAGGTTTCTGGGGAAAGGGCATCTGAGGCAGGGGACTCTATGGTGCAAAGGCCTGGCGTAAGGACAGGCATGATGAGAGAGGGAAAGGAGGTAAGGGCAGGAAGGTGGCAGGGATGCTTGTACTGCCTATTAGATATCCAGGAGTTACATACAGCAGGCATCTGAGGTGCCAGGACAGTGCACATATCTGGTGACAGAGCTGGATATGGGTTCTGTTAAGTGCAGAGATGGTATTTGCTGCCATGAGATGGCAGTGTTTCCCAAGGGTGGAAACTCAACGAGAGAAAGGTGCTCCCTGCAATGGGTAGGTACACAGTGAGGATTGTGGAACTTTAGCCACACCCCCTCATTCTGTGTGCCTCAGTGCTTCCAGCCCTCAGAAGAGATAAAGAAAACCAGCCTCCTAACTAAGGTTATCAGTAGGTTTCTTTTTCTCTCTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTAGTCCAGGCTGGAGTGCAGTGGCACAATCTTGGCTCACTGCAACCTCCACCTCCCGAGTTCAGGTAATTCCCCTGCCTCAGCCTCTGAAGCAGCTGGGATTACAGGTGCCCGCTGCCACACTCAGCAAATTTTTGTATTTTTAGTAGAGATAGAGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAGGTGCTGGGATTAGAGGCG
TAGTGAGACCTCACCTCTAATGAATGATAAATAAATAAATAAATAAATAAATAAATAAATAAACATACAATATGCTGGGCGTGGTGACTCACGCCTGTAATCCTAGCACTTTGGGAGGCCAAAGTGGGCAGAACACAAGGTCAGGAAGCTGAGGCAAGAGAATCGCTTGAACCCGAGGGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCCCTCCAGCCTGGGCAGCAGAGTGAGACTCCGTCTCAAAAACAGAAATTTCAAAATAATAATAATAATGATCTGGGGGCTGGGTACAGTGGCTCGCACCTGTAATCTCAACACTTTAGGAGACCAAGACAGGAGGACTGCTTGAGGCCAGGGATCCGAGACCAGCCAGAGCAACTTAGCAAGACCTCATCTCTACTAAAACTTAGAAAAGATTAGCTAGGTGTGGTGGGATGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGTAGGAGGATTGCTTCAGCTGGGAGGTCAAGGCTGCAGTGAGCCATGATTTTGACACTCCACTCCAGCGTGGATGACAGAGCAAAACCTTGTCTCAAAATAAAAAAGAAAAAAATGATTTGGAGAGAGGCAAGCAATCCAAGTTTGTCAAGGAGGGTCAGTTTTAGGACTTTTGTTGGAAACACTGGTCGAAAATTTCTTTACTCTGAAGTTCCTAAGCTGGAAGGGCACAGAAGGCTACAGCACTACCCAGAGGGAAGGTTGTGCCTAAGAATGAAGCCAACACAAGGGAAGCAGATCTGAGACCACAAAGATGCCTTTCACATCCTTTGAGCTCCTGGATACAGCCATACCCCTGAAGCCTTTGTTGATTTTTCATTTCTTTTTTTTTTTTTTTTGAGACGGAGTTTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGACCTTGGCTCACTACAACCTCAGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCACCCTCCCAAGCAGCTGGGACTACAGGCGCCTGCCACCACGCCCAGCTATTTTTTTATATTTTTAGTAGAAATGGGGTTTCACCGTGTTAGCCAGGCTGGTCTCGATCTTCTGACCTTGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGTGTCAGCCACCACATGTGGCCATTGATTTTTCATTTCTTTCCACCTATCAGTTACCTAATTTTGAAGTCTTCAAAAAGTGGCATTCTTACCACTTACACATAAATATATACTGAATGTAAACTGACAAGGATGTGGACTGAGAGAAGCACAGCAGGTGACCAGAAGGGAAGGCAGAGGCATAGCAAGGGGTCGAAGCTGGGGTAGGACAGTGGGCAGCAGCAGCACTCACTGGACCAGATGGGAGGCCAGGACTTCCTTGCAGATGGGCTGCTCGGCCAGCGTCAGCCAGAACTCACAGGCCTCAAGGGCAACGTTCTCATCATGGTCCTGGGTCCTCTGCAGCATGTACTGTGGTAGGGGGGAGAAGCTGAGGCCTGGCCTGGCTGGGGGTGGCTCCCTGACCCCTGCCACCGGCCCCCTGCCTGCCCGCCTGGGCTGGCCTTGACCATGCACACCTGGATGATGCTGTGCATGTGGGGGATGAGCCTGTCAATCCGCACTTCCAGAAGCATCACCAGGGCACGGCACACATTCTTCCGCACCTCGGGGTCATCATCCACAGCCAGGGCAAATAGGTGCTGCAGGGAGGAACAGGGTCAGTTGTAGGGGCCCTCAGTCCTCGCCCTGCCCACCCCCAGCCCAGCGGCCCACCTCGATGAAGGTGTCAATATTGTCCATCAGCGCCTGGGCCCGGTCCATGATGAACTGGTTCACGCAGGCGATGGCGTGGGACCTGGCGGGGAGCAGACACGTGGGTCACCCTGACCCTGCCCACTCCAGGCTCCCTGGAAGCCCCCAGGGAGCTGCACCCACCGGATCTTGGGACTGCAGTGCTTGAAGAACTGCAGGAACTTGGGGATCATGATGTTGAGGGGCCTGTTGAGGGCGTCACTGTCCAGAAGCTCTGATGAGTTTTCACAGATCTTCTGCAGGGCTCCAAAGGCTCCCTGAGTGCAGAGGGGCAGAGAGACAAACGTGGGTGGTGGGTGGTGGTCCCAGCCCCCCAGTACTCGCTCTGGCCATCCATGGCTTCTTGCCTACCTCACAAGTGTTGTAATCCTCCGAGTTAAGCAGGTTGCAGAGCTGGGGCAGCAGCTCGGGCCACATCTGCAGCTCACCCTTGGAAGCGATGGTGGTGATGAGAATGCCTGGGGCGGCCGGGAAAGGACGCTGCCTGAGGCTGGGCAGGGGCTGCCTAGCACCTCCCCCTCCCACTGGACACCCCCAGTGCTGCCTTTCTGTTCCCTAGCCCATGTACGCCCTCTACATCCCCCCTCCTTTTTTTTTTCTTTGTAAGAGATAGAATTAGCTCTGTTGCCCAGGCTGGACTGCTGTGGCACAATCAATAGTCCACAGCAGCCTCAAACTCCTGGCCTCAAGCCATCTTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTGCAGGCACATGCCACCACGCCCAACTAATTTTTAAAATTGTTTGTAGAGATGGGATCTCACTATGTTGCCCAGGCTGGCCTAAAACTCCTGGCCTCAAGCAATCCTCCTGCCTTGGCCTCCAAAAGCACTGAGATTACAGGCGTGAGCCACCGCTCCTGGCCTTGACATAGGTAGAAGGGTACTCCTTGACTCAGTAGGCACCCTGAGCCTTACTGTGAGTCAACTCTGTTCCAGGCCCTGAGGCACAGCACAGAGCAAAACACAAAATCCTCACCCTTGGGAGCTGGAAGCAAGCTATGAAGTAAAGATAAATTAGCAAAAAAAACTGGGAGGGGCCGTGCATGGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGGGACCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGGGGGCACCAGTAATCCCAGCTACTTGGGAGGCCGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCAGAGATCGCGCCACAGCACTCCAGCCTGGGATGGAGCAAGACTCCATTTCAAAAACAAACAAAACAAAAACAAACAACTGGGAGGGGCCACATGCCAAGGACTAAGGGGGGAAATACAGCAGAAAAGATGGTGAGAAAGGGCTGTAGGTGAAGGTAGCAACTTTAAATTGGGTGGCCAGAGCAGGCCTCGTTGAGGTGACATCTTGATATCTGAGCCAAGGCCTGAAGGAGGTGAAGGAGGCGAGGGAGGAATCATCCAGGTTTCTGGGGAAAGGGCATCTGAGGCAGGGGACTCTATGGTGCAAAGGCCTGGCGTAAGGACAGGCATGATGAGAGAGGGAAAGGAGGTAAGGGCAGGAAGGTGGCAGGGATGCTTGTACTGCCTATTAGATATCCAGGAGTTACATACAGCAGGCATCTGAGGTGCCAGGACAGTGCACATATCTGGTGACAGAGCTGGATATGGGTTCTGTTAAGTGCAGAGATGGTATTTGCTGCCATGAGATGGCAGTGTTTCCCAAGGGTGGAAACTCAACGAGAGAAAGGTGCTCCCTGCAATGGGTAGGTACACAGTGAGGATTGTGGAACTTTAGCCACACCCCCTCATTCTGTGTGCCTCAGTGCTTCCAGCCCTCAGAAGAGATAAAGAAAACCAGCCTCCTAACTAAGGTTATCAGTAGGTTTCTTTTTCTCTCTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTAGTCCAGGCTGGAGTGCAGTGGCACAATCTTGGCTCACTGCAACCTCCACCTCCCGAGTTCAGGTAATTCCCCTGCCTCAGCCTCTGAAGCAGCTGGGATTACAGGTGCCCGCTGCCACACTCAGCAAATTTTTGTATTTTTAGTAGAGATAGAGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAGGTGCTGGGATTAGAGGCG
Task1_train_26562
Here is a mutation in TNPO2 (transportin 2) on Chromosome 19. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies
TAGTGAGACCTCACCTCTAATGAATGATAAATAAATAAATAAATAAATAAATAAATAAATAAACATACAATATGCTGGGCGTGGTGACTCACGCCTGTAATCCTAGCACTTTGGGAGGCCAAAGTGGGCAGAACACAAGGTCAGGAAGCTGAGGCAAGAGAATCGCTTGAACCCGAGGGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCCCTCCAGCCTGGGCAGCAGAGTGAGACTCCGTCTCAAAAACAGAAATTTCAAAATAATAATAATAATGATCTGGGGGCTGGGTACAGTGGCTCGCACCTGTAATCTCAACACTTTAGGAGACCAAGACAGGAGGACTGCTTGAGGCCAGGGATCCGAGACCAGCCAGAGCAACTTAGCAAGACCTCATCTCTACTAAAACTTAGAAAAGATTAGCTAGGTGTGGTGGGATGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGTAGGAGGATTGCTTCAGCTGGGAGGTCAAGGCTGCAGTGAGCCATGATTTTGACACTCCACTCCAGCGTGGATGACAGAGCAAAACCTTGTCTCAAAATAAAAAAGAAAAAAATGATTTGGAGAGAGGCAAGCAATCCAAGTTTGTCAAGGAGGGTCAGTTTTAGGACTTTTGTTGGAAACACTGGTCGAAAATTTCTTTACTCTGAAGTTCCTAAGCTGGAAGGGCACAGAAGGCTACAGCACTACCCAGAGGGAAGGTTGTGCCTAAGAATGAAGCCAACACAAGGGAAGCAGATCTGAGACCACAAAGATGCCTTTCACATCCTTTGAGCTCCTGGATACAGCCATACCCCTGAAGCCTTTGTTGATTTTTCATTTCTTTTTTTTTTTTTTTTGAGACGGAGTTTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGACCTTGGCTCACTACAACCTCAGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCACCCTCCCAAGCAGCTGGGACTACAGGCGCCTGCCACCACGCCCAGCTATTTTTTTATATTTTTAGTAGAAATGGGGTTTCACCGTGTTAGCCAGGCTGGTCTCGATCTTCTGACCTTGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGTGTCAGCCACCACATGTGGCCATTGATTTTTCATTTCTTTCCACCTATCAGTTACCTAATTTTGAAGTCTTCAAAAAGTGGCATTCTTACCACTTACACATAAATATATACTGAATGTAAACTGACAAGGATGTGGACTGAGAGAAGCACAGCAGGTGACCAGAAGGGAAGGCAGAGGCATAGCAAGGGGTCGAAGCTGGGGTAGGACAGTGGGCAGCAGCAGCACTCACTGGACCAGATGGGAGGCCAGGACTTCCTTGCAGATGGGCTGCTCGGCCAGCGTCAGCCAGAACTCACAGGCCTCAAGGGCAACGTTCTCATCATGGTCCTGGGTCCTCTGCAGCATGTACTGTGGTAGGGGGGAGAAGCTGAGGCCTGGCCTGGCTGGGGGTGGCTCCCTGACCCCTGCCACCGGCCCCCTGCCTGCCCGCCTGGGCTGGCCTTGACCATGCACACCTGGATGATGCTGTGCATGTGGGGGATGAGCCTGTCAATCCGCACTTCCAGAAGCATCACCAGGGCACGGCACACATTCTTCCGCACCTCGGGGTCATCATCCACAGCCAGGGCAAATAGGTGCTGCAGGGAGGAACAGGGTCAGTTGTAGGGGCCCTCAGTCCTCGCCCTGCCCACCCCCAGCCCAGCGGCCCACCTCGATGAAGGTGTCAATATTGTCCATCAGCGCCTGGGCCCGGTCCATGATGAACTGGTTCACGCAGGCGATGGCGTGGGACCTGGCGGGGAGCAGACACGTGGGTCACCCTGACCCTGCCCACTCCAGGCTCCCTGGAAGCCCCCAGGGAGCTGCACCCACCGGATCTTGGGACTGCAGTGCTTGAAGAACTGCAGGAACTTGGGGATCATGATGTTGAGGGGCCTGTTGAGGGCGTCACTGTCCAGAAGCTCTGATGAGTCTTCACAGATCTTCTGCAGGGCTCCAAAGGCTCCCTGAGTGCAGAGGGGCAGAGAGACAAACGTGGGTGGTGGGTGGTGGTCCCAGCCCCCCAGTACTCGCTCTGGCCATCCATGGCTTCTTGCCTACCTCACAAGTGTTGTAATCCTCCGAGTTAAGCAGGTTGCAGAGCTGGGGCAGCAGCTCGGGCCACATCTGCAGCTCACCCTTGGAAGCGATGGTGGTGATGAGAATGCCTGGGGCGGCCGGGAAAGGACGCTGCCTGAGGCTGGGCAGGGGCTGCCTAGCACCTCCCCCTCCCACTGGACACCCCCAGTGCTGCCTTTCTGTTCCCTAGCCCATGTACGCCCTCTACATCCCCCCTCCTTTTTTTTTTCTTTGTAAGAGATAGAATTAGCTCTGTTGCCCAGGCTGGACTGCTGTGGCACAATCAATAGTCCACAGCAGCCTCAAACTCCTGGCCTCAAGCCATCTTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTGCAGGCACATGCCACCACGCCCAACTAATTTTTAAAATTGTTTGTAGAGATGGGATCTCACTATGTTGCCCAGGCTGGCCTAAAACTCCTGGCCTCAAGCAATCCTCCTGCCTTGGCCTCCAAAAGCACTGAGATTACAGGCGTGAGCCACCGCTCCTGGCCTTGACATAGGTAGAAGGGTACTCCTTGACTCAGTAGGCACCCTGAGCCTTACTGTGAGTCAACTCTGTTCCAGGCCCTGAGGCACAGCACAGAGCAAAACACAAAATCCTCACCCTTGGGAGCTGGAAGCAAGCTATGAAGTAAAGATAAATTAGCAAAAAAAACTGGGAGGGGCCGTGCATGGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGGGACCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGGGGGCACCAGTAATCCCAGCTACTTGGGAGGCCGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCAGAGATCGCGCCACAGCACTCCAGCCTGGGATGGAGCAAGACTCCATTTCAAAAACAAACAAAACAAAAACAAACAACTGGGAGGGGCCACATGCCAAGGACTAAGGGGGGAAATACAGCAGAAAAGATGGTGAGAAAGGGCTGTAGGTGAAGGTAGCAACTTTAAATTGGGTGGCCAGAGCAGGCCTCGTTGAGGTGACATCTTGATATCTGAGCCAAGGCCTGAAGGAGGTGAAGGAGGCGAGGGAGGAATCATCCAGGTTTCTGGGGAAAGGGCATCTGAGGCAGGGGACTCTATGGTGCAAAGGCCTGGCGTAAGGACAGGCATGATGAGAGAGGGAAAGGAGGTAAGGGCAGGAAGGTGGCAGGGATGCTTGTACTGCCTATTAGATATCCAGGAGTTACATACAGCAGGCATCTGAGGTGCCAGGACAGTGCACATATCTGGTGACAGAGCTGGATATGGGTTCTGTTAAGTGCAGAGATGGTATTTGCTGCCATGAGATGGCAGTGTTTCCCAAGGGTGGAAACTCAACGAGAGAAAGGTGCTCCCTGCAATGGGTAGGTACACAGTGAGGATTGTGGAACTTTAGCCACACCCCCTCATTCTGTGTGCCTCAGTGCTTCCAGCCCTCAGAAGAGATAAAGAAAACCAGCCTCCTAACTAAGGTTATCAGTAGGTTTCTTTTTCTCTCTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTAGTCCAGGCTGGAGTGCAGTGGCACAATCTTGGCTCACTGCAACCTCCACCTCCCGAGTTCAGGTAATTCCCCTGCCTCAGCCTCTGAAGCAGCTGGGATTACAGGTGCCCGCTGCCACACTCAGCAAATTTTTGTATTTTTAGTAGAGATAGAGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAGGTGCTGGGATTAGAGGCG
TAGTGAGACCTCACCTCTAATGAATGATAAATAAATAAATAAATAAATAAATAAATAAATAAACATACAATATGCTGGGCGTGGTGACTCACGCCTGTAATCCTAGCACTTTGGGAGGCCAAAGTGGGCAGAACACAAGGTCAGGAAGCTGAGGCAAGAGAATCGCTTGAACCCGAGGGGCGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCCCTCCAGCCTGGGCAGCAGAGTGAGACTCCGTCTCAAAAACAGAAATTTCAAAATAATAATAATAATGATCTGGGGGCTGGGTACAGTGGCTCGCACCTGTAATCTCAACACTTTAGGAGACCAAGACAGGAGGACTGCTTGAGGCCAGGGATCCGAGACCAGCCAGAGCAACTTAGCAAGACCTCATCTCTACTAAAACTTAGAAAAGATTAGCTAGGTGTGGTGGGATGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGTAGGAGGATTGCTTCAGCTGGGAGGTCAAGGCTGCAGTGAGCCATGATTTTGACACTCCACTCCAGCGTGGATGACAGAGCAAAACCTTGTCTCAAAATAAAAAAGAAAAAAATGATTTGGAGAGAGGCAAGCAATCCAAGTTTGTCAAGGAGGGTCAGTTTTAGGACTTTTGTTGGAAACACTGGTCGAAAATTTCTTTACTCTGAAGTTCCTAAGCTGGAAGGGCACAGAAGGCTACAGCACTACCCAGAGGGAAGGTTGTGCCTAAGAATGAAGCCAACACAAGGGAAGCAGATCTGAGACCACAAAGATGCCTTTCACATCCTTTGAGCTCCTGGATACAGCCATACCCCTGAAGCCTTTGTTGATTTTTCATTTCTTTTTTTTTTTTTTTTGAGACGGAGTTTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGACCTTGGCTCACTACAACCTCAGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCACCCTCCCAAGCAGCTGGGACTACAGGCGCCTGCCACCACGCCCAGCTATTTTTTTATATTTTTAGTAGAAATGGGGTTTCACCGTGTTAGCCAGGCTGGTCTCGATCTTCTGACCTTGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGTGTCAGCCACCACATGTGGCCATTGATTTTTCATTTCTTTCCACCTATCAGTTACCTAATTTTGAAGTCTTCAAAAAGTGGCATTCTTACCACTTACACATAAATATATACTGAATGTAAACTGACAAGGATGTGGACTGAGAGAAGCACAGCAGGTGACCAGAAGGGAAGGCAGAGGCATAGCAAGGGGTCGAAGCTGGGGTAGGACAGTGGGCAGCAGCAGCACTCACTGGACCAGATGGGAGGCCAGGACTTCCTTGCAGATGGGCTGCTCGGCCAGCGTCAGCCAGAACTCACAGGCCTCAAGGGCAACGTTCTCATCATGGTCCTGGGTCCTCTGCAGCATGTACTGTGGTAGGGGGGAGAAGCTGAGGCCTGGCCTGGCTGGGGGTGGCTCCCTGACCCCTGCCACCGGCCCCCTGCCTGCCCGCCTGGGCTGGCCTTGACCATGCACACCTGGATGATGCTGTGCATGTGGGGGATGAGCCTGTCAATCCGCACTTCCAGAAGCATCACCAGGGCACGGCACACATTCTTCCGCACCTCGGGGTCATCATCCACAGCCAGGGCAAATAGGTGCTGCAGGGAGGAACAGGGTCAGTTGTAGGGGCCCTCAGTCCTCGCCCTGCCCACCCCCAGCCCAGCGGCCCACCTCGATGAAGGTGTCAATATTGTCCATCAGCGCCTGGGCCCGGTCCATGATGAACTGGTTCACGCAGGCGATGGCGTGGGACCTGGCGGGGAGCAGACACGTGGGTCACCCTGACCCTGCCCACTCCAGGCTCCCTGGAAGCCCCCAGGGAGCTGCACCCACCGGATCTTGGGACTGCAGTGCTTGAAGAACTGCAGGAACTTGGGGATCATGATGTTGAGGGGCCTGTTGAGGGCGTCACTGTCCAGAAGCTCTGATGAGTTTTCACAGATCTTCTGCAGGGCTCCAAAGGCTCCCTGAGTGCAGAGGGGCAGAGAGACAAACGTGGGTGGTGGGTGGTGGTCCCAGCCCCCCAGTACTCGCTCTGGCCATCCATGGCTTCTTGCCTACCTCACAAGTGTTGTAATCCTCCGAGTTAAGCAGGTTGCAGAGCTGGGGCAGCAGCTCGGGCCACATCTGCAGCTCACCCTTGGAAGCGATGGTGGTGATGAGAATGCCTGGGGCGGCCGGGAAAGGACGCTGCCTGAGGCTGGGCAGGGGCTGCCTAGCACCTCCCCCTCCCACTGGACACCCCCAGTGCTGCCTTTCTGTTCCCTAGCCCATGTACGCCCTCTACATCCCCCCTCCTTTTTTTTTTCTTTGTAAGAGATAGAATTAGCTCTGTTGCCCAGGCTGGACTGCTGTGGCACAATCAATAGTCCACAGCAGCCTCAAACTCCTGGCCTCAAGCCATCTTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTGCAGGCACATGCCACCACGCCCAACTAATTTTTAAAATTGTTTGTAGAGATGGGATCTCACTATGTTGCCCAGGCTGGCCTAAAACTCCTGGCCTCAAGCAATCCTCCTGCCTTGGCCTCCAAAAGCACTGAGATTACAGGCGTGAGCCACCGCTCCTGGCCTTGACATAGGTAGAAGGGTACTCCTTGACTCAGTAGGCACCCTGAGCCTTACTGTGAGTCAACTCTGTTCCAGGCCCTGAGGCACAGCACAGAGCAAAACACAAAATCCTCACCCTTGGGAGCTGGAAGCAAGCTATGAAGTAAAGATAAATTAGCAAAAAAAACTGGGAGGGGCCGTGCATGGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGGGACCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGGGGGCACCAGTAATCCCAGCTACTTGGGAGGCCGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCAGAGATCGCGCCACAGCACTCCAGCCTGGGATGGAGCAAGACTCCATTTCAAAAACAAACAAAACAAAAACAAACAACTGGGAGGGGCCACATGCCAAGGACTAAGGGGGGAAATACAGCAGAAAAGATGGTGAGAAAGGGCTGTAGGTGAAGGTAGCAACTTTAAATTGGGTGGCCAGAGCAGGCCTCGTTGAGGTGACATCTTGATATCTGAGCCAAGGCCTGAAGGAGGTGAAGGAGGCGAGGGAGGAATCATCCAGGTTTCTGGGGAAAGGGCATCTGAGGCAGGGGACTCTATGGTGCAAAGGCCTGGCGTAAGGACAGGCATGATGAGAGAGGGAAAGGAGGTAAGGGCAGGAAGGTGGCAGGGATGCTTGTACTGCCTATTAGATATCCAGGAGTTACATACAGCAGGCATCTGAGGTGCCAGGACAGTGCACATATCTGGTGACAGAGCTGGATATGGGTTCTGTTAAGTGCAGAGATGGTATTTGCTGCCATGAGATGGCAGTGTTTCCCAAGGGTGGAAACTCAACGAGAGAAAGGTGCTCCCTGCAATGGGTAGGTACACAGTGAGGATTGTGGAACTTTAGCCACACCCCCTCATTCTGTGTGCCTCAGTGCTTCCAGCCCTCAGAAGAGATAAAGAAAACCAGCCTCCTAACTAAGGTTATCAGTAGGTTTCTTTTTCTCTCTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTAGTCCAGGCTGGAGTGCAGTGGCACAATCTTGGCTCACTGCAACCTCCACCTCCCGAGTTCAGGTAATTCCCCTGCCTCAGCCTCTGAAGCAGCTGGGATTACAGGTGCCCGCTGCCACACTCAGCAAATTTTTGTATTTTTAGTAGAGATAGAGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAGGTGCTGGGATTAGAGGCG
Task1_train_26563
Given this variant in gene GET3 (guided entry of tail-anchored proteins factor 3, ATPase) on Chromosome 19, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Cardiomyopathy, dilated, 2H
ACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCATCTCTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAGGCTCCGCCCCCTGGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCACCTCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTAACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGGTGGGGCATGCCTATAGTCTCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGAAGGTGGAGGTTGTGATGAGCTGAGATCGCGCCACTGCACTCCAGCCTAGGCAACAAGATCAAAACTCCATCTCGGGAAAAAAAAAAAAAAAAGAGGGAGGCATTGAGTCTGAGACTGGCCAGGGACCCCAGCCATGGCCATCCCTTCATAGATTCTACATACATGTTTGTGTTTTGTTTTGTTGTTTGTTTTTTGAGACAGAGTCTCCCTCTGTCACCCAGGCTGGAGTGTAATGGCGTGATCTCGGCTCACTGTAACCTCTGCCTCCCGGGTTCAAGCGATTCCCCTGCCTCAACCTCCAGAGTAGCTGGGATTATAGGCACCCGCCACTATGCATGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGCCTCAAGCTCCCGACCTCAGGTGATCTGCCCGCCTCCGCTTCCCAAAGGGCTGGAATTACAGGCATGAGGTACCGCGCCTGGCTGGATTCCCCATATGTGCTGACGACCTCTGTGCCAGGCACTGTTCATGCTAAGCGCTAAGGACACAGCAGTGAACTAGATGGTAAAACCCCTGCCCCTGAGGGGCAGACATTCCTGCTATGGAGACAGATGATAAACATGATAAGGGAATCATGAGGGATGTGAGGAAGGGCTAATTTTTTTTTCAGATAGGTCTTGCTATATTGCCCAGGCTGGTGTCCAACTCCTGGGCTCAAGCGATCCTCCCATCTCATTCTCCTGAGTACCTGGGACTACAGGCGTGAGCTATCCTGCCCAGCTCCTAAGGGCTAAACCTTAAGGAGAAAGGAAGGCAGGGCAGGGGTGTCGGTGGATCTGTGCTGTTACTTAGGGTGGTCAGGGAGTCTCTCAGTGGAGGGATGATGATCCGGAAGAGGTCATGGCCCAGTCATGGGAGTATCTGGGGTTGCAAGTGGCAGGTTGCAAGTGGGGAGTAGCAGTGTAAATGGCCCGCAGTGGGTTTCAGCTTCCCTTTGAGGGCCCTGGGCACAGCTTGCAATTTTCCCCTTGTTTTTGACCCTTTATGCAACCATACAAAACCCTAAGTACTACCTCAGGGTCCCCCCAGCCGTGACCTAATGAAATGCCTGTGGTCACAGCCCACCACAGGCTCCCTCTGGCCCTGTGCCCGGGTAGGAAGGCTCCCCCTGGCCCTGTGCCCAGGTGGGAAGGCTCCCCCAGCAGTAGCAGCAACCTCAGTCTCATCCCTTTGGCCCCCAGGAGATTGACCCCAGCCTGGGCGTGGCGGAGCTGCCTGACGAGTTCTTCGAGGAGGACAACATGCTGAGCATGGGCAAGAAGATGATGCAGGAGGCCATGAGCGCATTTCCCGGCATCGATGAGGCCATGAGCTATGCCGAGGTCATGAGGTCAGGCCCAGCCAGCAGGGGTGGGGGCTGCCTGGGGAAGGGGAAGAGCGGACACAGAGGGCCTGACCCCTGTCTCCCCTCAGGCTGGTGAAGGGCATGAACTTCTCGGTGGTGGTATTTGACACGGCACCCACGGGCCACACCCTGAGGCTGCTCAACTTCCCCACCATCGTGGAGCGGGGCCTGGGCCGGCTTATGCAGATCAAGAACCAGATCAGCCCTTTCATCTCACAGGCAGGCGGCGGGGGCCCCCACCTGCACCATCCAGGCAGCCGGGAGTGGGAGTAGGCCCGGGCCCCCAGACCCTCAAATGCGCACTAACAATTCCCTTTCCTTCCCACCCCTTCTCACTCTGGACTTCTCCCTGGAGGGGATGGGACGGAGCTGTCTTTCCTCCCCCACAGGCAGGACTCAGTGTCCCTGCCCCTGCCCGCTAAATACCCTAGACAGAGCCAGAAAGCACATTCCAGAACCAGGCAACCTGCCTTCAAACCCTCTACACTCACCATGTGACCCAACTGCTGTGTGACCTCAAGCAAATCACTTCACCTCTCTGGGCCTCACCTTCCTTGTCTTGCAAATGGAGATCATGAGAGTGCCCCATGGGTTATTATTATTATTATTCGAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTTGGCTCATTGCAACCTCCACCTCGTGGGTTCAAGTGATTCTCGTGCCTCTACCTCCCAAGTAGCTGGGACTACAGACATGTACCACCATGCCCAGCTAATTTTTGTACTTTTTGTAGAGATAGGGTTTTGCCATGTTGCCCAGGCTGGTCTTGAACTCCTGGCCTCAAGCAGTACACCCACTTCGACCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCAGCCCCCATGGGTTATTATTACGATGACAACCCTAAAGCCCCCACAGTGCTGCACACCACCAGCACCACCCACCATGGTGTATGTGCACGTGTGGGTGTGTGCGTGTCCCCTGTGGGGACCTGTGCCTCAGGTGGTAACACTGAGCACTTACTGTGTGCCAGACACTATTCTCAGCACATTATATGCTTCAGCTCATCTGGTACAACAGATCTGGGAGGTAAAGTTTAGAGATGGGGAAACTGAGGCTCCAGGAGGGTCAAGCCCCTTAGCTATGGTTCCCTAAAAATGGCAAAGCTGAGGCCGGCCGCAGTGGCTCATGCCTGTAATCCTAGGACTTCGCAAGGCCGAGGCAGGTGGATTGCCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAAATGGTGAAACCCCACCAGTACTAAAAATACAAAAATTAGCCGGGCATGGTGGTGCGCGCCTGTAATCCCAGCTACTCAAGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGCGGTTGCAGTGAGCCAAAATCACGCCATTGTACTCCAGCCTGGGCAACAGAGTGAGACTCCATTTCAAAAAAAAAAAAAAAAGAAAGAAAGAAATGGAAAAGCTAGTATTTGACCAACCCCAGGAATCTGCTTATGGGCCTGAGCCTTTAACCACTGGGAGGTATCAGGAGTCATCCCTCGGGTGTTTAGTGAACCCCCAACCCAGGAGGTCGCCGCAGGTAAGCTATGAGCCCTCCCACATCCCCCCTGCAGATGTGCAACATGCTGGGCCTGGGGGACATGAACGCAGACCAGCTGGCCTCCAAGCTGGAGGAGACGCTGCCCGTCATCCGCTCAGTCAGCGAACAGTTCAAGGACCCTGTGAGTGGTGGTCTGGCTGGCGGTGAGAGGCCCGGGGGCTGAGGACAGGGGCAGACCCCGCCCCTCACTGTCCTCTCTCGTGCCCTGTAGGAGCAGACAACTTTCATCTGCGTATGCATTGCTGAGTTCCTGTCCCTGTATGAGACAGAGAGGCTGATCCAGGAGCTGGCCAAGTGCAAGATTGACACACACAATATAATTGTCAACCAGCTCGTCTTCCCCGACCCCGAGAAGCCCTGCAAGATGTGTGAGGCCCGTCACAAGATCCAGGCCAAGTATCTGGACCAGGTGTGCCCACCCACCCAGCACTGGCTCAGCAGAGGCACCTCTGCCCCTTTATTCTCTGATCTTTTGCTCCACCATCTGGCCCTCTGCCCTCTA
ACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCATCTCTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAGGCTCCGCCCCCTGGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCACCTCGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTAACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGGTGGGGCATGCCTATAGTCTCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGAAGGTGGAGGTTGTGATGAGCTGAGATCGCGCCACTGCACTCCAGCCTAGGCAACAAGATCAAAACTCCATCTCGGGAAAAAAAAAAAAAAAAGAGGGAGGCATTGAGTCTGAGACTGGCCAGGGACCCCAGCCATGGCCATCCCTTCATAGATTCTACATACATGTTTGTGTTTTGTTTTGTTGTTTGTTTTTTGAGACAGAGTCTCCCTCTGTCACCCAGGCTGGAGTGTAATGGCGTGATCTCGGCTCACTGTAACCTCTGCCTCCCGGGTTCAAGCGATTCCCCTGCCTCAACCTCCAGAGTAGCTGGGATTATAGGCACCCGCCACTATGCATGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGCCTCAAGCTCCCGACCTCAGGTGATCTGCCCGCCTCCGCTTCCCAAAGGGCTGGAATTACAGGCATGAGGTACCGCGCCTGGCTGGATTCCCCATATGTGCTGACGACCTCTGTGCCAGGCACTGTTCATGCTAAGCGCTAAGGACACAGCAGTGAACTAGATGGTAAAACCCCTGCCCCTGAGGGGCAGACATTCCTGCTATGGAGACAGATGATAAACATGATAAGGGAATCATGAGGGATGTGAGGAAGGGCTAATTTTTTTTTCAGATAGGTCTTGCTATATTGCCCAGGCTGGTGTCCAACTCCTGGGCTCAAGCGATCCTCCCATCTCATTCTCCTGAGTACCTGGGACTACAGGCGTGAGCTATCCTGCCCAGCTCCTAAGGGCTAAACCTTAAGGAGAAAGGAAGGCAGGGCAGGGGTGTCGGTGGATCTGTGCTGTTACTTAGGGTGGTCAGGGAGTCTCTCAGTGGAGGGATGATGATCCGGAAGAGGTCATGGCCCAGTCATGGGAGTATCTGGGGTTGCAAGTGGCAGGTTGCAAGTGGGGAGTAGCAGTGTAAATGGCCCGCAGTGGGTTTCAGCTTCCCTTTGAGGGCCCTGGGCACAGCTTGCAATTTTCCCCTTGTTTTTGACCCTTTATGCAACCATACAAAACCCTAAGTACTACCTCAGGGTCCCCCCAGCCGTGACCTAATGAAATGCCTGTGGTCACAGCCCACCACAGGCTCCCTCTGGCCCTGTGCCCGGGTAGGAAGGCTCCCCCTGGCCCTGTGCCCAGGTGGGAAGGCTCCCCCAGCAGTAGCAGCAACCTCAGTCTCATCCCTTTGGCCCCCAGGAGATTGACCCCAGCCTGGGCGTGGCGGAGCTGCCTGACGAGTTCTTCGAGGAGGACAACATGCTGAGCATGGGCAAGAAGATGATGCAGGAGGCCATGAGCGCATTTCCCGGCATCGATGAGGCCATGAGCTATGCCGAGGTCATGAGGTCAGGCCCAGCCAGCAGGGGTGGGGGCTGCCTGGGGAAGGGGAAGAGCGGACACAGAGGGCCTGACCCCTGTCTCCCCTCAGGCTGGTGAAGGGCATGAACTTCTCGGTGGCGGTATTTGACACGGCACCCACGGGCCACACCCTGAGGCTGCTCAACTTCCCCACCATCGTGGAGCGGGGCCTGGGCCGGCTTATGCAGATCAAGAACCAGATCAGCCCTTTCATCTCACAGGCAGGCGGCGGGGGCCCCCACCTGCACCATCCAGGCAGCCGGGAGTGGGAGTAGGCCCGGGCCCCCAGACCCTCAAATGCGCACTAACAATTCCCTTTCCTTCCCACCCCTTCTCACTCTGGACTTCTCCCTGGAGGGGATGGGACGGAGCTGTCTTTCCTCCCCCACAGGCAGGACTCAGTGTCCCTGCCCCTGCCCGCTAAATACCCTAGACAGAGCCAGAAAGCACATTCCAGAACCAGGCAACCTGCCTTCAAACCCTCTACACTCACCATGTGACCCAACTGCTGTGTGACCTCAAGCAAATCACTTCACCTCTCTGGGCCTCACCTTCCTTGTCTTGCAAATGGAGATCATGAGAGTGCCCCATGGGTTATTATTATTATTATTCGAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTTGGCTCATTGCAACCTCCACCTCGTGGGTTCAAGTGATTCTCGTGCCTCTACCTCCCAAGTAGCTGGGACTACAGACATGTACCACCATGCCCAGCTAATTTTTGTACTTTTTGTAGAGATAGGGTTTTGCCATGTTGCCCAGGCTGGTCTTGAACTCCTGGCCTCAAGCAGTACACCCACTTCGACCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCAGCCCCCATGGGTTATTATTACGATGACAACCCTAAAGCCCCCACAGTGCTGCACACCACCAGCACCACCCACCATGGTGTATGTGCACGTGTGGGTGTGTGCGTGTCCCCTGTGGGGACCTGTGCCTCAGGTGGTAACACTGAGCACTTACTGTGTGCCAGACACTATTCTCAGCACATTATATGCTTCAGCTCATCTGGTACAACAGATCTGGGAGGTAAAGTTTAGAGATGGGGAAACTGAGGCTCCAGGAGGGTCAAGCCCCTTAGCTATGGTTCCCTAAAAATGGCAAAGCTGAGGCCGGCCGCAGTGGCTCATGCCTGTAATCCTAGGACTTCGCAAGGCCGAGGCAGGTGGATTGCCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAAATGGTGAAACCCCACCAGTACTAAAAATACAAAAATTAGCCGGGCATGGTGGTGCGCGCCTGTAATCCCAGCTACTCAAGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGCGGTTGCAGTGAGCCAAAATCACGCCATTGTACTCCAGCCTGGGCAACAGAGTGAGACTCCATTTCAAAAAAAAAAAAAAAAGAAAGAAAGAAATGGAAAAGCTAGTATTTGACCAACCCCAGGAATCTGCTTATGGGCCTGAGCCTTTAACCACTGGGAGGTATCAGGAGTCATCCCTCGGGTGTTTAGTGAACCCCCAACCCAGGAGGTCGCCGCAGGTAAGCTATGAGCCCTCCCACATCCCCCCTGCAGATGTGCAACATGCTGGGCCTGGGGGACATGAACGCAGACCAGCTGGCCTCCAAGCTGGAGGAGACGCTGCCCGTCATCCGCTCAGTCAGCGAACAGTTCAAGGACCCTGTGAGTGGTGGTCTGGCTGGCGGTGAGAGGCCCGGGGGCTGAGGACAGGGGCAGACCCCGCCCCTCACTGTCCTCTCTCGTGCCCTGTAGGAGCAGACAACTTTCATCTGCGTATGCATTGCTGAGTTCCTGTCCCTGTATGAGACAGAGAGGCTGATCCAGGAGCTGGCCAAGTGCAAGATTGACACACACAATATAATTGTCAACCAGCTCGTCTTCCCCGACCCCGAGAAGCCCTGCAAGATGTGTGAGGCCCGTCACAAGATCCAGGCCAAGTATCTGGACCAGGTGTGCCCACCCACCCAGCACTGGCTCAGCAGAGGCACCTCTGCCCCTTTATTCTCTGATCTTTTGCTCCACCATCTGGCCCTCTGCCCTCTA
Task1_train_26564
A genomic change on Chromosome 19 affects LOC117038795, RNASEH2A (CRISPRi-FlowFISH-validated PRDX2 regulatory element 4| ribonuclease H2 subunit A). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Aicardi-Goutieres syndrome 4
ATCGAGACCATCCTGGCTAAAACGGTGAAACCCCGTCTCTACTAAAAATATAAAAAATTAGCTGGGCGCGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCGGAGCCTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAACCAACCAAACAAACAAACAAACAAAAACATTTAAGTTAGATGAGCGTGGCGGCACATGCCTGTGGTCCCAGCTACTCGGTACGATGGGGAGGAAGGATCGCTTGAGCCTGGGAGGCAAAGGTTACAATAAGCCGAGATCGCTACACTGCTATCCAGCCTGGGCAACAGAGTAACATCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTGGAGGGGGAGGCGAAGAGGAGTAAAAGGAGATAAAGAGACAATGAACTAGGACCCTGAGGAAGGGGCATGAGCCTGGTAAGGGGCGGGAACCCACAGGCAGAGGACATGAGCCCCAGTGAGCCCAGGGAATAGAAGTGGTGGATGCCAGGCACTGTGGCTGGCTCAGGCTTGTAATCCCAACACTTTGGGAGGCTGAGGCGACCGGATCGCTTGAGCCCAGGAGTTTGAAGCCAGCCTGGGCAACATAATGAGACCCCGTCTCTACAAAAAATACCAAAAATAGTCGGGCATGGTGGTGTGGTGTGCACCTGTAGTCCAGCTGCTTGGGAGACTGAGGTGGGAGGATCGCGTCAGCCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGACAACAGAGAGAGACCCTGTCTAAAAAAAAAAGAAGGCCGGGTGCGGTGGCTCACGCCTGCAATCCCAACACTTTGGGAGGCCGAGGCGGGCGGATCACAAGGTCAGGAAATCGAGACCAACCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAAGTACAAAAAATTAGCCGGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTATTCGGGAGACTGAGGCAGGAGAATGGCGTGAACCCGGGACGCGGAGCTTGCAGTGAGCGGAGATGGCGCCATTGCACTCCAGCCTGGGCGACAAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAGAAAAAAAAAAAGTGGGTCGAGGGGTGGGGGTGGGGACATTCATTCTAAGTTGGGAGGAATGAGCTTCTATAGGGAGCAGAGACCCTGAGCAGGAGTCCACCGAGGTCTGTGATCTCCAACGGGGGTGGGGAAGGCTTGGCCTGAATGAGACAGAGGTTAGGAAGCACAGATCTTGCACGGAGTGGAGGTGGGCCGAAGGGAGCAACCAAGAGAGGGAGTTTGGGGACTCCAAATCCAAAAGCCTGGGTTTAGTGGAAGCGGGGCTACCTGGTCCAGGGGACTTAGAATGTGTACAGAAGCAGGGACCGCAAGTACAGGGCCTGAATCCAAGTGGCAGTTGGGGACCCAGTGATGCGGTGACCCGTGTCCTGGGAGTGGGGTGATATTTGACTCTCTAGTTCCCCGTTAGGCTGGGTCTTCGAAGCTACGTCTCAGTTTCCCTCTTATTTCCCCCTCTTCCCACCGGGCCACGCAGGCGGGGCCCCAGAGACCGTGAAGCAGAGCTTGCAAAGTGACCCCGTCCACCGAATTCCCCAAGCTGAGTGTTCGGCCATAGCCCTTCGGGACTACAATTCCCAGGAGGGCGCACGGCAGCGACGTCGGCGTCGGCTGCGTAAGCGTCCACGGCGGCGGGAGCGCCAGGGGCGTGTTCTGCCCGCGGATTGGCCGGAAGCAGGCGCCGCTTCGAGGCCCGCGGAAAACGCGCGCCGAGACCCGCTCCTGCAGTATTAGTTCTTGCAGCTGGTGGTGGCGGCTGAGGCGGCATGGATCTCAGCGAGCTGGAGAGAGACAATACAGGCCGCTGTCGCCTGAGTTCGCCTGTGCCCGCGGTGTGCCGCAAGGAGCCTTGCGTCCTGGGCGTCGATGAGGCGGGCAGGGGCCCCGTGCTGGGTGCGCCCCTAGGGCCAGGGAGGGGAGGGGCGTGGTACGGAGGATGCGGGAAACGGGAGTCGGGATTGCACTGCACCAAGGGAGGGGATGTGGTCGTGGTGATGGCACCTAAAGAAGCAGTGATGATAGAACAGGGATGAATGGCAACTTTCACGGGCTCAGTGATTGGACCCCGGCTGCCAGAAAACTGACACCCCTTCTCCCCAGGCCCCATGGTCTACGCCATCTGTTATTGTCCCCTGCCTCGCCTGGCAGATCTGGAGGCGCTGAAAGTGGCAGGTGAGCCCGAGGTGTGCGTCTGGGGAAGGGATTCCTGGGTATGTGCAGGGGCAGGTGAGAACTGAAAGGGGAGGGCAGGAACTGGGAGAACCAGCTGTTCCCCTTCTCTTCCAAACCTCCTCCCAGACTCAAAGACCCTATTGGAGAGCGAGCGGGAAAGGCTGTTTGCGAAAATGGAGGACACGGACTTTGTCGGCTGGGCGCTGGATGTGCTGTCTCCAAACCTCATCTCTACCAGCATGCTTGGGCGGTGAGGGGTCCCCGGGAGGGGCAGCCAGCATGGGCTGACCAAGCTTTGTTCCTAGAATGAGATTAACTGGGCTCTGTTCCCCACCACAGGGTCAAATACAACCTGAACTCCCTGTCACATGATACAGCCACTGGGCTTATACAGTATGCATTGGACCAGGGCGTGAACGTCACCCAGGTGAGTTAACTGTAAGTTGTCCCCATTTGGTCATCTCAGGATAAAATGGGGACAAAACAGGAGTTCGAGACTGCAGTGAGCCATGATCATGCCACAGCACTCCATCCTGGGTGACAAAGGAAGCCCCCCAACTCAAAAATGGAGGCAGGGCGCAGTGGCTCACGCCTATAATCGCAGCACTTTGGGAAGCCGCGGCGGGTAGATCACCGGAGGTCAAGAGTTCGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGACGTGGTGGCAGGCGCCTGTAATCCTAGCTACTCAGGAGGCTGAGACAGGAGAATCGCTTGAACCCAGGAGGCAGAAGTTGCAGTGAGCCAAGATTGTGCCATTGCACTCCAACCCGGGCAACAGAGCAAGACCCTGTCTCAAAAAAATAAAAAATAAAAAATAAACTAAAAATGGGAGACCAGGCGCAGTGGCTCACGGCTGTAATCCCAGCGTTTCAGGAGGCTGAGGCAGGCAGATCACCTGAGGTCAGGAGTTGAAGACCATCCTGGCCAACATGGTGAAACCTCATCTCTACTGAAAATACAAAAAATTAGCCCAGCATGGTGGCGGGTGCCTGTAATCCCACCTATTGGTGAGGCCGAGGCAGAAGAATTGCTCGAACCCGGGAGGCGGAGGTTGCAGTGAGGTGAGATCGCGCCATTGCACTCCAGCCTGGGGGACAGAGCGAAAAATAAAAATAAAAATAAAATAAAAAATAAATGTGGGCAAAAATGTGCAGTGTGCAGATTCAGCATCAGATACGTCTGGAGTGCCTCGGGCATATTCATTGCTACTGTTGATTTCGTGCTCCTGTTTCTGCCCTAAATGTGTGCCACACTGACGACCACAGTGTAGCCCCTAGTCCCGTCTCCATCTAATCTCTCCCTCATCCTAAAGGCTCAGTCTCCAGAACAAATCCTACATTGTCTACCTGTCACCTCTGTCCTAGCCCAGGACACCCCCCACTCCCTGGACACCTGCTGAGTGTCGTCTCTCGTCCCTCACCCTCCTATCCCCTCCAATCTGTTCCCCAAGCAGCAACAGAAGGTAGTCTTTTTGAAATGCACATCTCGACATTTAGTTTTCCGATCACAGTGGAAATTAAATCAGGAAAATTCACAGTCGAGTGGGGCAGAATTACATTAAATTACCAGAGAAAAACATAAATCAGCATTGCCTCGAATGCTCTCAATGAAAGAATGGACCGTTCTGAGAGAATAACAAGGCAAAATAACCTTGACGTAGGAATTGTATGCTGGGTATGGTGGCTCACGCCT
ATCGAGACCATCCTGGCTAAAACGGTGAAACCCCGTCTCTACTAAAAATATAAAAAATTAGCTGGGCGCGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCGGAGCCTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAACCAACCAAACAAACAAACAAACAAAAACATTTAAGTTAGATGAGCGTGGCGGCACATGCCTGTGGTCCCAGCTACTCGGTACGATGGGGAGGAAGGATCGCTTGAGCCTGGGAGGCAAAGGTTACAATAAGCCGAGATCGCTACACTGCTATCCAGCCTGGGCAACAGAGTAACATCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTGGAGGGGGAGGCGAAGAGGAGTAAAAGGAGATAAAGAGACAATGAACTAGGACCCTGAGGAAGGGGCATGAGCCTGGTAAGGGGCGGGAACCCACAGGCAGAGGACATGAGCCCCAGTGAGCCCAGGGAATAGAAGTGGTGGATGCCAGGCACTGTGGCTGGCTCAGGCTTGTAATCCCAACACTTTGGGAGGCTGAGGCGACCGGATCGCTTGAGCCCAGGAGTTTGAAGCCAGCCTGGGCAACATAATGAGACCCCGTCTCTACAAAAAATACCAAAAATAGTCGGGCATGGTGGTGTGGTGTGCACCTGTAGTCCAGCTGCTTGGGAGACTGAGGTGGGAGGATCGCGTCAGCCCAGGAGGTGGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGACAACAGAGAGAGACCCTGTCTAAAAAAAAAAGAAGGCCGGGTGCGGTGGCTCACGCCTGCAATCCCAACACTTTGGGAGGCCGAGGCGGGCGGATCACAAGGTCAGGAAATCGAGACCAACCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAAGTACAAAAAATTAGCCGGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTATTCGGGAGACTGAGGCAGGAGAATGGCGTGAACCCGGGACGCGGAGCTTGCAGTGAGCGGAGATGGCGCCATTGCACTCCAGCCTGGGCGACAAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAGAAAAAAAAAAAGTGGGTCGAGGGGTGGGGGTGGGGACATTCATTCTAAGTTGGGAGGAATGAGCTTCTATAGGGAGCAGAGACCCTGAGCAGGAGTCCACCGAGGTCTGTGATCTCCAACGGGGGTGGGGAAGGCTTGGCCTGAATGAGACAGAGGTTAGGAAGCACAGATCTTGCACGGAGTGGAGGTGGGCCGAAGGGAGCAACCAAGAGAGGGAGTTTGGGGACTCCAAATCCAAAAGCCTGGGTTTAGTGGAAGCGGGGCTACCTGGTCCAGGGGACTTAGAATGTGTACAGAAGCAGGGACCGCAAGTACAGGGCCTGAATCCAAGTGGCAGTTGGGGACCCAGTGATGCGGTGACCCGTGTCCTGGGAGTGGGGTGATATTTGACTCTCTAGTTCCCCGTTAGGCTGGGTCTTCGAAGCTACGTCTCAGTTTCCCTCTTATTTCCCCCTCTTCCCACCGGGCCACGCAGGCGGGGCCCCAGAGACCGTGAAGCAGAGCTTGCAAAGTGACCCCGTCCACCGAATTCCCCAAGCTGAGTGTTCGGCCATAGCCCTTCGGGACTACAATTCCCAGGAGGGCGCACGGCAGCGACGTCGGCGTCGGCTGCGTAAGCGTCCACGGCGGCGGGAGCGCCAGGGGCGTGTTCTGCCCGCGGATTGGCCGGAAGCAGGCGCCGCTTCGAGGCCCGCGGAAAACGCGCGCCGAGACCCGCTCCTGCAGTATTAGTTCTTGCAGCTGGTGGTGGCGGCTGAGGCGGCATGGATCTCAGCGAGCTGGAGAGAGACAATACAGGCCGCTGTCGCCTGAGTTCGCCTGTGCCCGCGGTGTGCCGCAAGGAGCCTTGCGTCCTGGGCGTCGATGAGGCGAGCAGGGGCCCCGTGCTGGGTGCGCCCCTAGGGCCAGGGAGGGGAGGGGCGTGGTACGGAGGATGCGGGAAACGGGAGTCGGGATTGCACTGCACCAAGGGAGGGGATGTGGTCGTGGTGATGGCACCTAAAGAAGCAGTGATGATAGAACAGGGATGAATGGCAACTTTCACGGGCTCAGTGATTGGACCCCGGCTGCCAGAAAACTGACACCCCTTCTCCCCAGGCCCCATGGTCTACGCCATCTGTTATTGTCCCCTGCCTCGCCTGGCAGATCTGGAGGCGCTGAAAGTGGCAGGTGAGCCCGAGGTGTGCGTCTGGGGAAGGGATTCCTGGGTATGTGCAGGGGCAGGTGAGAACTGAAAGGGGAGGGCAGGAACTGGGAGAACCAGCTGTTCCCCTTCTCTTCCAAACCTCCTCCCAGACTCAAAGACCCTATTGGAGAGCGAGCGGGAAAGGCTGTTTGCGAAAATGGAGGACACGGACTTTGTCGGCTGGGCGCTGGATGTGCTGTCTCCAAACCTCATCTCTACCAGCATGCTTGGGCGGTGAGGGGTCCCCGGGAGGGGCAGCCAGCATGGGCTGACCAAGCTTTGTTCCTAGAATGAGATTAACTGGGCTCTGTTCCCCACCACAGGGTCAAATACAACCTGAACTCCCTGTCACATGATACAGCCACTGGGCTTATACAGTATGCATTGGACCAGGGCGTGAACGTCACCCAGGTGAGTTAACTGTAAGTTGTCCCCATTTGGTCATCTCAGGATAAAATGGGGACAAAACAGGAGTTCGAGACTGCAGTGAGCCATGATCATGCCACAGCACTCCATCCTGGGTGACAAAGGAAGCCCCCCAACTCAAAAATGGAGGCAGGGCGCAGTGGCTCACGCCTATAATCGCAGCACTTTGGGAAGCCGCGGCGGGTAGATCACCGGAGGTCAAGAGTTCGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGACGTGGTGGCAGGCGCCTGTAATCCTAGCTACTCAGGAGGCTGAGACAGGAGAATCGCTTGAACCCAGGAGGCAGAAGTTGCAGTGAGCCAAGATTGTGCCATTGCACTCCAACCCGGGCAACAGAGCAAGACCCTGTCTCAAAAAAATAAAAAATAAAAAATAAACTAAAAATGGGAGACCAGGCGCAGTGGCTCACGGCTGTAATCCCAGCGTTTCAGGAGGCTGAGGCAGGCAGATCACCTGAGGTCAGGAGTTGAAGACCATCCTGGCCAACATGGTGAAACCTCATCTCTACTGAAAATACAAAAAATTAGCCCAGCATGGTGGCGGGTGCCTGTAATCCCACCTATTGGTGAGGCCGAGGCAGAAGAATTGCTCGAACCCGGGAGGCGGAGGTTGCAGTGAGGTGAGATCGCGCCATTGCACTCCAGCCTGGGGGACAGAGCGAAAAATAAAAATAAAAATAAAATAAAAAATAAATGTGGGCAAAAATGTGCAGTGTGCAGATTCAGCATCAGATACGTCTGGAGTGCCTCGGGCATATTCATTGCTACTGTTGATTTCGTGCTCCTGTTTCTGCCCTAAATGTGTGCCACACTGACGACCACAGTGTAGCCCCTAGTCCCGTCTCCATCTAATCTCTCCCTCATCCTAAAGGCTCAGTCTCCAGAACAAATCCTACATTGTCTACCTGTCACCTCTGTCCTAGCCCAGGACACCCCCCACTCCCTGGACACCTGCTGAGTGTCGTCTCTCGTCCCTCACCCTCCTATCCCCTCCAATCTGTTCCCCAAGCAGCAACAGAAGGTAGTCTTTTTGAAATGCACATCTCGACATTTAGTTTTCCGATCACAGTGGAAATTAAATCAGGAAAATTCACAGTCGAGTGGGGCAGAATTACATTAAATTACCAGAGAAAAACATAAATCAGCATTGCCTCGAATGCTCTCAATGAAAGAATGGACCGTTCTGAGAGAATAACAAGGCAAAATAACCTTGACGTAGGAATTGTATGCTGGGTATGGTGGCTCACGCCT
Task1_train_26565
Gene RNASEH2A (ribonuclease H2 subunit A), found on Chromosome 19, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Aicardi-Goutieres syndrome 4
AGGTAGGAGAACCGCTTGAGTCCTCGAGTTCAAGACCAGCCTGGGCAACATAGCGAGACCCCCATCTCTATAAAAAATTTAAAAAATTAGCCGGTTATAGTGGTGCCCACCTGTAGTCCCAGCTACTCTGGAGGAGGAGGCTAAGGTGGGTGGGTTGCTTGAGCCCAGGAGTTGGAGGCTGCAGTGAGCTATGATTATGCCACTGCACTCCAGCCTTGGTGACAAGATGAGATCTTGTGTCAAAAAAAAAAATAATGTTAGCCAGGCGTGGTGGCTCACACCTGTAATCCCAGGACTTTGGGAGGCTGAGGCAGGTGGATCCTTTGAGGTCAGGAGTTCTAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAATTAGCTGGACGTGGTGGCACACGCCCGTAATCCCAGCAACTCGGGAGGCTGAGGCAGGAGAATTACTTAAACCTGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGCATAATTGCACTCCAGCCTGGGAAATGAGCAAAATTCCATCTCAAAATAATAATAATAATAATAATAATAATATTTAATGACAGGCTGGGCCAGGTGGCTCATGCCCGTAATCCTAGCATTTTAAGAGACAGAGGCAGGTAGATCATGTGAACTCAGGAATTCACAACCAGCCTGGGCAATATGACAAGACCCCATCTCTACAAAAAATACAAAAATTAGGTGTGGTGGTGCGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTGAGAGGATGGCTTGAGCCTGGGAGGCAGAGGTTGCATTGAGCTGTGATAATGTCACTGCACTCCAGCCTGGGTAATAGAGCGAGACCCTATCTCAAAAAAATAAAAAGGCTGGGTGTGGTGTTTACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGCCTGTCCAATATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGTATGGTGGTGGGTGGCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTACAGCCTGGGTGACAGAGCAAGACTCCATTTCAAAAAATAAGTAAATAAAATAAAAATGTTTAATGACTTGTTCTTGGAGGTCAAGGAGATGTCTCAGAGGCAGTCTCCCTGCACTGCCCTTTTAGCAGCTCTTGGCCAGGTAAAGGTCCTGTGGCAAGAAGGTGCTTCAGACCATAGGAGGTGCCCCAGGTACTCAGGAGGAAGCCTTAGAAGAGCGGCAAGGAGGCCGGGCGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGGGGGTAGATCACGAGGTCAAGCAATTGAGACCATCCTGGCCAACATGGTGAAACCTCGTCACTACTAAAAACACAAAATTTAGCTGGGCATGGTGGCATGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCGGGAGGTGGAGGTTGCAGTGAGCTGAGATCGCGCCACTGCACTCCAGCCTGGCTACAGAGTGGGACTCCATCTCAAAGAAAAAAAAAAGAGTGGCAGGGAGCTTGAATGTTATGGTGCAACTTGGACTGTCACCATTGCCCACCCTACCCCAGATCCCAAGACAAAAGCGTGGTTGAAGGAGCACGTGGAGCCTGTGTTCGGCTTCCCCCAGTTTGTCCGGTTCAGCTGGCGCACGGCCCAGACCATCCTGGAGAAAGAGGCGGAAGATGTTATATGGTGGGTGTCATGGATGTCCTGGGGGTGCTATAGGGAAGGAAGGAGGGAGGCCAGCGTTCAGCCCTGCCTGAGAGGGTTGCTCCCTGTGTAAGTGGTCACTGTCATCACCTCTCTCCCACAGGGAGGACTCAGCATCCGAGAATCAGGAGGGACTCAGGAAGATCACATCCTACTTCCTCAATGAAGGGTCCCAAGCCCGTCCCCGTTCTTCCCACCGATATTTCCTGGAACGCGGCCTGGAGTCAGCAACCAGCCTCTAGCAGCTGCCTCTACGCGCTCTACCTGCTTCCCCAACCCAGACATTAAAATTGTTTAAGGAGAACCACACGTAGGGGATGTACTTTTGGGACAGAAGCAAGGTGGGAGTGTGCTCTGCAGCCGGGTCCAGCTACTTCCTTTTGGAACCTTAAATAGAATGGGTGTTGGTTGATTAATTTTATTTGGTTTGATTTTTTTCATTTTTAAATTTTATTTATTTTATTTTATTTTATTTTATTTTTTTGAGAGACGAAGTCTCACTCTGTCACCCAGGCTGGAGTAGAATGGGGCAATCTCAGCTCACTGCAACCTCTGCCTTCCAGGTTCAAGCGATTCTCCTGCCTCAATTTCCCAAGCAGCTGGGACTATAGGCGTGTGCCATGCCCAACTAATTTTTTTTTTTTTTTGAGACACAGTCTCCTGTTGCCCAGGCTGGAGTACCATGGCACAATCTTGGCTCACTGCAACCTCCACCTCCCTGGTTCAAGCAATTCCCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCACACCACCACACCCGGCTAATTTTCTTTTCTTTTCTTTCTTTCTTTTTTTTTTAATTTGAGACAGAGTCTCACTTTGTCACCAGGCTGGAGTGCAGTGATGCAATTTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCACGTAGCTGTGACTACAGGCATGCGCCACCACACTCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCACGTTGGCCAGACTGGTCTTAAACTGCTGACCTCAGGCAATCTGCCCGCCTTGGCCTCTCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGCCTGGCCTAATTTTTGTATTTTTTAGTAGAGACAAGGTTTCACTATATGTTAGTCAGGCTGCTCTCTACCTCCTGACCTCAGGTGATCTGCCCACCTCAGCCTCTCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCGACCTTTTTAGTTATATTTTTAATTTTTAAAAATTTTTAAATTTTCTTTCTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCATTGGCTCAATCTTAGCTCACTGTAACCTCTGCCTCCCAGGTTCAAATGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCGTGCCACCAGGCCTGGCTAATTTTTTGTATTTTTAGTAGAAACACGGTTTCACCGTGTTAGCCATGATGGTCTCAATCTTCTGACCTTGTGATCCGTCTGCTTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCGCCATGCATTGCCTATTTTTATTTAAAAAATTTTTTGAGACAGAATCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTCAGTGTAACCTCCGCCTCCTGGGTTTAAGTGATTCTCCCACCTTAACCTCCTGAGTAGCTGAGGTTCCAGGCACACGCCACGATGCCCAACTAATTTTTGTATTTTTTGTAGAGATGAGGTTTCATCATGTCGCCCAGGCTGGTCTTGTAGTCCTGGGTTCAAGTGATCTGCCCGCTGTGACCTCTCAATGTGTGAGCTACCATACCTGGCTGACTAATATGTAAAATACATGATGTGGCTGGGCGCAGGGGCTCATACATGTAATCCTAGTGCTTTGGAAGGCTGAGTCAGGAGGATCTTGACCAGTCTGGACAACATAGGGTAACAAGAGCGAAACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAATGCTGGGCTGCATGGGGGAAGATAAGAAAAAATAAAGAAAGGTCACGAACCAAACAAAAATCTTGGCGGGCAGGGTGCCGTGTGGCTGCAGTCCCAGCTTTTCTGGAGGTTGAGGTAGGCTCCAGCATGGGCGACAGAGCAAGACCATGTCTCAAAAAAAAAAGCATATCTGCGCATTAATGTTTGGAACAAGCTGCATTCTCTCCAGAAGGACCTAGAA
AGGTAGGAGAACCGCTTGAGTCCTCGAGTTCAAGACCAGCCTGGGCAACATAGCGAGACCCCCATCTCTATAAAAAATTTAAAAAATTAGCCGGTTATAGTGGTGCCCACCTGTAGTCCCAGCTACTCTGGAGGAGGAGGCTAAGGTGGGTGGGTTGCTTGAGCCCAGGAGTTGGAGGCTGCAGTGAGCTATGATTATGCCACTGCACTCCAGCCTTGGTGACAAGATGAGATCTTGTGTCAAAAAAAAAAATAATGTTAGCCAGGCGTGGTGGCTCACACCTGTAATCCCAGGACTTTGGGAGGCTGAGGCAGGTGGATCCTTTGAGGTCAGGAGTTCTAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAATTAGCTGGACGTGGTGGCACACGCCCGTAATCCCAGCAACTCGGGAGGCTGAGGCAGGAGAATTACTTAAACCTGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGCATAATTGCACTCCAGCCTGGGAAATGAGCAAAATTCCATCTCAAAATAATAATAATAATAATAATAATAATATTTAATGACAGGCTGGGCCAGGTGGCTCATGCCCGTAATCCTAGCATTTTAAGAGACAGAGGCAGGTAGATCATGTGAACTCAGGAATTCACAACCAGCCTGGGCAATATGACAAGACCCCATCTCTACAAAAAATACAAAAATTAGGTGTGGTGGTGCGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTGAGAGGATGGCTTGAGCCTGGGAGGCAGAGGTTGCATTGAGCTGTGATAATGTCACTGCACTCCAGCCTGGGTAATAGAGCGAGACCCTATCTCAAAAAAATAAAAAGGCTGGGTGTGGTGTTTACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGCCTGTCCAATATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGTATGGTGGTGGGTGGCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTACAGCCTGGGTGACAGAGCAAGACTCCATTTCAAAAAATAAGTAAATAAAATAAAAATGTTTAATGACTTGTTCTTGGAGGTCAAGGAGATGTCTCAGAGGCAGTCTCCCTGCACTGCCCTTTTAGCAGCTCTTGGCCAGGTAAAGGTCCTGTGGCAAGAAGGTGCTTCAGACCATAGGAGGTGCCCCAGGTACTCAGGAGGAAGCCTTAGAAGAGCGGCAAGGAGGCCGGGCGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGGGGGTAGATCACGAGGTCAAGCAATTGAGACCATCCTGGCCAACATGGTGAAACCTCGTCACTACTAAAAACACAAAATTTAGCTGGGCATGGTGGCATGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCGGGAGGTGGAGGTTGCAGTGAGCTGAGATCGCGCCACTGCACTCCAGCCTGGCTACAGAGTGGGACTCCATCTCAAAGAAAAAAAAAAGAGTGGCAGGGAGCTTGAATGTTATGGTGCAACTTGGACTGTCACCATTGCCCACCCTACCCCAGATCCCAAGACAAAAGCGTGGTTGAAGGAGCACGTGGAGCCTGTGTTCGGCTTCCCCCAGTTTGTCCGGTTCAGCTGGCGCACGGCCCAGACCATCCTGGAGAAAGAGGCGGAAGATGTTATATGGTGGGTGTCATGGATGTCCTGGGGGTGCTATAGGGAAGGAAGGAGGGAGGCCAGCGTTCAGCCCTGCCTGAGAGGGTTGCTCCCTGTGTAAGTGGTCACTGTCATCACCTCTCTCCCACAGGGAGGACTCAGCATCCGAGAATCAGGAGGGACTCAGGAAGATCACATCCTACTTCCTCAATGAAGGGTCCCAAGCCCGTCCCCGTTCTTCCCACCGACATTTCCTGGAACGCGGCCTGGAGTCAGCAACCAGCCTCTAGCAGCTGCCTCTACGCGCTCTACCTGCTTCCCCAACCCAGACATTAAAATTGTTTAAGGAGAACCACACGTAGGGGATGTACTTTTGGGACAGAAGCAAGGTGGGAGTGTGCTCTGCAGCCGGGTCCAGCTACTTCCTTTTGGAACCTTAAATAGAATGGGTGTTGGTTGATTAATTTTATTTGGTTTGATTTTTTTCATTTTTAAATTTTATTTATTTTATTTTATTTTATTTTATTTTTTTGAGAGACGAAGTCTCACTCTGTCACCCAGGCTGGAGTAGAATGGGGCAATCTCAGCTCACTGCAACCTCTGCCTTCCAGGTTCAAGCGATTCTCCTGCCTCAATTTCCCAAGCAGCTGGGACTATAGGCGTGTGCCATGCCCAACTAATTTTTTTTTTTTTTTGAGACACAGTCTCCTGTTGCCCAGGCTGGAGTACCATGGCACAATCTTGGCTCACTGCAACCTCCACCTCCCTGGTTCAAGCAATTCCCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCACACCACCACACCCGGCTAATTTTCTTTTCTTTTCTTTCTTTCTTTTTTTTTTAATTTGAGACAGAGTCTCACTTTGTCACCAGGCTGGAGTGCAGTGATGCAATTTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCACGTAGCTGTGACTACAGGCATGCGCCACCACACTCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCACGTTGGCCAGACTGGTCTTAAACTGCTGACCTCAGGCAATCTGCCCGCCTTGGCCTCTCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGCCTGGCCTAATTTTTGTATTTTTTAGTAGAGACAAGGTTTCACTATATGTTAGTCAGGCTGCTCTCTACCTCCTGACCTCAGGTGATCTGCCCACCTCAGCCTCTCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCGACCTTTTTAGTTATATTTTTAATTTTTAAAAATTTTTAAATTTTCTTTCTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCATTGGCTCAATCTTAGCTCACTGTAACCTCTGCCTCCCAGGTTCAAATGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCGTGCCACCAGGCCTGGCTAATTTTTTGTATTTTTAGTAGAAACACGGTTTCACCGTGTTAGCCATGATGGTCTCAATCTTCTGACCTTGTGATCCGTCTGCTTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCGCCATGCATTGCCTATTTTTATTTAAAAAATTTTTTGAGACAGAATCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTCAGTGTAACCTCCGCCTCCTGGGTTTAAGTGATTCTCCCACCTTAACCTCCTGAGTAGCTGAGGTTCCAGGCACACGCCACGATGCCCAACTAATTTTTGTATTTTTTGTAGAGATGAGGTTTCATCATGTCGCCCAGGCTGGTCTTGTAGTCCTGGGTTCAAGTGATCTGCCCGCTGTGACCTCTCAATGTGTGAGCTACCATACCTGGCTGACTAATATGTAAAATACATGATGTGGCTGGGCGCAGGGGCTCATACATGTAATCCTAGTGCTTTGGAAGGCTGAGTCAGGAGGATCTTGACCAGTCTGGACAACATAGGGTAACAAGAGCGAAACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAATGCTGGGCTGCATGGGGGAAGATAAGAAAAAATAAAGAAAGGTCACGAACCAAACAAAAATCTTGGCGGGCAGGGTGCCGTGTGGCTGCAGTCCCAGCTTTTCTGGAGGTTGAGGTAGGCTCCAGCATGGGCGACAGAGCAAGACCATGTCTCAAAAAAAAAAGCATATCTGCGCATTAATGTTTGGAACAAGCTGCATTCTCTCCAGAAGGACCTAGAA
Task1_train_26566
A variant was discovered in gene LOC117125587, MAST1 (CRISPRi-FlowFISH-validated KLF1 and PRDX2 regulatory element| microtubule associated serine/threonine kinase 1), Chromosome 19. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations
TGGGATTACAGGCGTGAGCCACCGAGCCCTGCCCTCAGTCCCAGAACTTTGAGAGGCCAAAGTGGGAGTATTGCTTGAAGCCAGGAGTTGGAAGCCAGCCTGGGCAACATAGAGAGACCCTGTCTCTGCAAAAAAGAATTAGCCAAGCATGGTGTAGTCCCAGCTACACAGAAGGCAGAGGGGGGAAGATTACTTTAGCCCAGGAGTTCAAGGCTTCCGTGAGCCATGATTGTACTACATCCCTCTAGCCTGGGTGACACAAGGAGACCGTGTCTCTCTCTCTTTTTAACTTTAAATAATTTTAATAAATAGAGACACAGTTTCACTATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAATGATCCTCCCGCCTTCGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGTCACCATATTCAGTGGAGACCCTTCTCTAAAATAATAATGATAATAAAGCAAGAGGAAACAAGATAGAGTAGGGATAGGGAATAATGGGTGTGTATTCAGAGGAGGTCTTCCCGAGGGGTGACATTGAAGCAAAAATTTGAAGGATGAGAAGGAGGGATCCATAGTAGATGTGTTCCAAGCAGAAAGAATAGCTAATGCAAAGGCCCTGAGGAAGGAGCTTGCCTGGCTTGTCCAAGGACCATCAAGGAGGCCACTAGGCTGGGTGCGGTGGCTTGTGCCTGTAATCTCAGCACTTTGGGAGGCAGAGGCAGGTGGATCACCTGATGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACACTGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGACAGGCACCTGTAATCCCAGCTACTTAGGAGGCTGAGTCAGGAGAATCGCTTGAACGCGGGAGGCGGAGGTTGCAGTGAGCTGAGATCACACTCCAAACTAGGCAACAAGAACGAAACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAGAAGGCCACTGTAGCTGGAGCAGAGGAAGTAAGCAGGAGAGTGAGAAAAATCCACGGCAGGGACCCAGGGCAGGATGAGGCAGGACCTTGTATAACTGGGGAAGGACTTGGGTGTTCACCCTGAGTAAGGTGGGAGCCACCAAGGGTTCTGAACAGAGGAGGCTCATGACTTGACCCAAGCTTTAACAGACTCACTGTCTCCACCCCTGTCTGTCCCTGTCCACCTGTCTGTGGCCAAGAGTCCCAGCCAAGATCCTAGGATCCAAGGATCGTAAATCAGGTCCTGATCCTGGCCTTGCCCAGTGACCCCATCGGCTTTGGGAGTCCCAGCTCAGGGTCCTGAGCTGTTGGGGGGCCCATGGTGGCTCTGACCCCGGCCCTGCCCCTGTCCCCAGTCCTCCTGCTCCTCCCAGGAGCGCCTTCACCAGCTGCCCTACCAGCCCACGGTGGACGAGCTCCACTTCCTCTCCAAACACTTCGGGAGCACCGAGAGCATCACAGACGAGGATGGTGGCCGTCGCTCCCCAGCCGTGCGGCCCCGCTCACGGAGCCTCAGGTGGGCAGGCATCCCTCCTCCTTCGTACCAAGCTAGTGGTCTTAGGACTTGTGCTTAGAGAGACCCCTGTCCCCGCGAATAAAAGGGTTACATCTTGGGGCGGGGGCTCTCTGCGGGCTTGGAGGCAGAGGACTCGACAAAATGGGCTTCTCTCCCCGCAGCCCCGGGCGCTCCCCCTCCTCCTACGACAACGAGATCGTGATGATGAATCACGTCTACAAGGAGAGGTTCCCGAAGGTGAGGTGGGACCCGAGGCGGTCACGGGGTGACCAGGCGGCCTGCACTCTCGCTCGCCTTATCCCCGCGCGCCCCCTGGCGGCCTCGGTGCGCAGCGCAGGCTCCTGGCGGCCGCAGCCTTCGGGCACAGCCCCGCGCCCCTCCTCCGTCCCTCCCGCAGGCCACTGCGCAGATGGAGGAGAAGCTGCGCGACTTTACCCGCGCCTACGAACCCGACAGCGTTCTGCCTCTGGCCGATGGCGTGCTCAGCTTCATCCACCACCAGATCATCGAGCTGGCCCGGGACTGCCTGACCAAGTCCCGTGACGGCCTCATCACCACGGTCTACTTCTATGAATTGCAGGAGAACCTGGAGAAGCTCCTTCAAGACGTGAGTGCACGCGGAGGCCGGGCTGATCTCAGGCTCAGCACCGCCAGATTGTGCCCAATGCACCCCTTTCTTCACCCCACATACATTCAGGGAGCTCCTACCACGTTCCAGGCACTGGCGTGGAGCTGAGGACTCAGGGGTGGAAGTGGTCCCTTCCCTAGGTCTGACCGACTGAAGAGGCAGGAATTTCACCTCGCTCATTTCCCTTAGGTCTTTACTCAAATGTCACCTTTTCAGGTGGCTTCTTAGGCGGTCCCCAGTCATTTAAAATATTAAACTCGGCCGGGCTCGGTGGCTCAGGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGGGGGCGGATCACGAGGTCAAGAGATCGAGACCATCCTGGCTAACACGGTGACACCCCGTCTCTACTAAAAACACACACACACACAAAATTAGCCGGGCGTGGTGGCGGACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTAAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATTGCGCCGCTGTACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAATAATAATAGTAAATAAAATAAAATAAAATAAAATATTAAACTTAGCCGGGTGCGGTGGCTCAGGCCTGTAATCCCAGCACTCTGGGAGGCTGAGGCAAGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGGGCGCCTGTAATCCCAACTACTTGGGAGGCAGAGGCGGGAGAATCGCTTGAACCTGGGAGTCGGAGGTTGCGGTGAGCCGAGATCACACCATTGCACTCCAGTCTGAGCAACAAGAGTGAAACTCTGTCTCAAAAATAAATAAATAAATGAAATAAAATAAAATATTAAACTCTACTCACATTTATCACCCACTTTCTCCTCAGTTTCTCCTTGACACTCAGCACCATCCATCATACTGTGTATTTTTGCTTATTTTATTTCATGTCTATCCTTCTCCAATGTCAGCCCCATAGTTGGTGAGGGTGGGGGGGTGGAGTTGTCTGTTCTGTCCACTGCTGTGTCCCTGCTGTTTGGAACAATACCCAGCACACAGTAGGTACTCAATAAATGTTGGGTAAATTGATGCTTGAATGTCCCTTTGCAGTGGCATGCACCTGTAGTCCCAGCTAGCTACTTAGGAGGCTGAGATGGGAGGATTGCTTGAGGTCAGGAGCTTGAGACCAGCTTGGGCAACATAGCAGGACCCCATCTCTAAAACAATTTAAAAAATTTAAGCCAGGCGAGGTTGCTCACGCCTTTAATCCCAGCACTTTGGGAGGCTGAGGCGAGCAGATCACGAGGTCAGGAGTTTGAAACCAGCCTGGCCAATAAGGTGAAACTCTGTCTTTACTAAAAATACAAAAAAGTTAGCCGGGCTTGGTGGCACGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGCTTGAATCCGGGAGGCAGTGGTTGCAGTGAGCCGAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGATTCTGTCTCAAAAAAAATAAAAATAAAAATAAAAATAATTAGCTAGGTGTAGTGGCACACACCTGCTGTCCCAGCTACTTGAGAGGCTGAGGCAGGAGGATCACTTGATCATTCATTAATTCCACCAATATTTATTTATTTATTTATTTTATTTTTTTTGGAGACAGAGTCTCACTCTATCCCACTGGGCTGGAGTGCAGTGGTGCGATTTTGGCTCACTGCAACCTCCACCTCTCAGGTTCAAGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATCACAGGCACCCACCACCATGCCTGGCTAATTTTTGTATTTTTAGTCGAGGCAGGGTTTCACCATGTTGGCCAGGCTGGTCTCTAAC
TGGGATTACAGGCGTGAGCCACCGAGCCCTGCCCTCAGTCCCAGAACTTTGAGAGGCCAAAGTGGGAGTATTGCTTGAAGCCAGGAGTTGGAAGCCAGCCTGGGCAACATAGAGAGACCCTGTCTCTGCAAAAAAGAATTAGCCAAGCATGGTGTAGTCCCAGCTACACAGAAGGCAGAGGGGGGAAGATTACTTTAGCCCAGGAGTTCAAGGCTTCCGTGAGCCATGATTGTACTACATCCCTCTAGCCTGGGTGACACAAGGAGACCGTGTCTCTCTCTCTTTTTAACTTTAAATAATTTTAATAAATAGAGACACAGTTTCACTATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAATGATCCTCCCGCCTTCGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGTCACCATATTCAGTGGAGACCCTTCTCTAAAATAATAATGATAATAAAGCAAGAGGAAACAAGATAGAGTAGGGATAGGGAATAATGGGTGTGTATTCAGAGGAGGTCTTCCCGAGGGGTGACATTGAAGCAAAAATTTGAAGGATGAGAAGGAGGGATCCATAGTAGATGTGTTCCAAGCAGAAAGAATAGCTAATGCAAAGGCCCTGAGGAAGGAGCTTGCCTGGCTTGTCCAAGGACCATCAAGGAGGCCACTAGGCTGGGTGCGGTGGCTTGTGCCTGTAATCTCAGCACTTTGGGAGGCAGAGGCAGGTGGATCACCTGATGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACACTGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGACAGGCACCTGTAATCCCAGCTACTTAGGAGGCTGAGTCAGGAGAATCGCTTGAACGCGGGAGGCGGAGGTTGCAGTGAGCTGAGATCACACTCCAAACTAGGCAACAAGAACGAAACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAGAAGGCCACTGTAGCTGGAGCAGAGGAAGTAAGCAGGAGAGTGAGAAAAATCCACGGCAGGGACCCAGGGCAGGATGAGGCAGGACCTTGTATAACTGGGGAAGGACTTGGGTGTTCACCCTGAGTAAGGTGGGAGCCACCAAGGGTTCTGAACAGAGGAGGCTCATGACTTGACCCAAGCTTTAACAGACTCACTGTCTCCACCCCTGTCTGTCCCTGTCCACCTGTCTGTGGCCAAGAGTCCCAGCCAAGATCCTAGGATCCAAGGATCGTAAATCAGGTCCTGATCCTGGCCTTGCCCAGTGACCCCATCGGCTTTGGGAGTCCCAGCTCAGGGTCCTGAGCTGTTGGGGGGCCCATGGTGGCTCTGACCCCGGCCCTGCCCCTGTCCCCAGTCCTCCTGCTCCTCCCAGGAGCGCCTTCACCAGCTGCCCTACCAGCCCACGGTGGACGAGCTCCACTTCCTCTCCAAACACTTCGGGAGCACCGAGAGCATCACAGACGAGGATGGTGGCCGTCGCTCCCCAGCCGTGCGGCCCCGCTCACGGAGCCTCAGGTGGGCAGGCATCCCTCCTCCTTCGTACCAAGCTAGTGGTCTTAGGACTTGTGCTTAGAGAGACCCCTGTCCCCGCGAATAAAAGGGTTACATCTTGGGGCGGGGGCTCTCTGCGGGCTTGGAGGCAGAGGACTCGACAAAATGGGCTTCTCTCCCCGCAGCCCCGGGCGCTCCCCCTCCTCCTACGACAACGAGATCGTGATGATGAATCACGTCTACAAGGAGAGGTTCCCGAAGGTGAGGTGGGACCCGAGGCGGTCACGGGGTGACCAGGCGGCCTGCACTCTCGCTCGCCTTATCCCCGCGCGCCCCCTGGCGGCCTCGGTGCGCAGCGCAGGCTCCTGGCGGCCGCAGCCTTCGGGCACAGCCCCGCGCCCCTCCTCCGTCCCTCCCGCAGGCCACTGCGCAGATGGAGGAGAAGCTGCGCGACTTTACCCGCGCCTACGAACCCGACAGCGTTCTGCCTCTGGCCGATGGCGTGCTCAGCTTCATCCACCACCAGATCATCGAGCTGGCCCGGGACCGCCTGACCAAGTCCCGTGACGGCCTCATCACCACGGTCTACTTCTATGAATTGCAGGAGAACCTGGAGAAGCTCCTTCAAGACGTGAGTGCACGCGGAGGCCGGGCTGATCTCAGGCTCAGCACCGCCAGATTGTGCCCAATGCACCCCTTTCTTCACCCCACATACATTCAGGGAGCTCCTACCACGTTCCAGGCACTGGCGTGGAGCTGAGGACTCAGGGGTGGAAGTGGTCCCTTCCCTAGGTCTGACCGACTGAAGAGGCAGGAATTTCACCTCGCTCATTTCCCTTAGGTCTTTACTCAAATGTCACCTTTTCAGGTGGCTTCTTAGGCGGTCCCCAGTCATTTAAAATATTAAACTCGGCCGGGCTCGGTGGCTCAGGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGGGGGCGGATCACGAGGTCAAGAGATCGAGACCATCCTGGCTAACACGGTGACACCCCGTCTCTACTAAAAACACACACACACACAAAATTAGCCGGGCGTGGTGGCGGACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTAAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATTGCGCCGCTGTACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAATAATAATAGTAAATAAAATAAAATAAAATAAAATATTAAACTTAGCCGGGTGCGGTGGCTCAGGCCTGTAATCCCAGCACTCTGGGAGGCTGAGGCAAGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGGGCGCCTGTAATCCCAACTACTTGGGAGGCAGAGGCGGGAGAATCGCTTGAACCTGGGAGTCGGAGGTTGCGGTGAGCCGAGATCACACCATTGCACTCCAGTCTGAGCAACAAGAGTGAAACTCTGTCTCAAAAATAAATAAATAAATGAAATAAAATAAAATATTAAACTCTACTCACATTTATCACCCACTTTCTCCTCAGTTTCTCCTTGACACTCAGCACCATCCATCATACTGTGTATTTTTGCTTATTTTATTTCATGTCTATCCTTCTCCAATGTCAGCCCCATAGTTGGTGAGGGTGGGGGGGTGGAGTTGTCTGTTCTGTCCACTGCTGTGTCCCTGCTGTTTGGAACAATACCCAGCACACAGTAGGTACTCAATAAATGTTGGGTAAATTGATGCTTGAATGTCCCTTTGCAGTGGCATGCACCTGTAGTCCCAGCTAGCTACTTAGGAGGCTGAGATGGGAGGATTGCTTGAGGTCAGGAGCTTGAGACCAGCTTGGGCAACATAGCAGGACCCCATCTCTAAAACAATTTAAAAAATTTAAGCCAGGCGAGGTTGCTCACGCCTTTAATCCCAGCACTTTGGGAGGCTGAGGCGAGCAGATCACGAGGTCAGGAGTTTGAAACCAGCCTGGCCAATAAGGTGAAACTCTGTCTTTACTAAAAATACAAAAAAGTTAGCCGGGCTTGGTGGCACGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGCTTGAATCCGGGAGGCAGTGGTTGCAGTGAGCCGAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGATTCTGTCTCAAAAAAAATAAAAATAAAAATAAAAATAATTAGCTAGGTGTAGTGGCACACACCTGCTGTCCCAGCTACTTGAGAGGCTGAGGCAGGAGGATCACTTGATCATTCATTAATTCCACCAATATTTATTTATTTATTTATTTTATTTTTTTTGGAGACAGAGTCTCACTCTATCCCACTGGGCTGGAGTGCAGTGGTGCGATTTTGGCTCACTGCAACCTCCACCTCTCAGGTTCAAGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATCACAGGCACCCACCACCATGCCTGGCTAATTTTTGTATTTTTAGTCGAGGCAGGGTTTCACCATGTTGGCCAGGCTGGTCTCTAAC
Task1_train_26567
A variant affecting Chromosome 19, within the gene MAST1 (microtubule associated serine/threonine kinase 1), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations
CGGGAGGCTGAGGAACAAGAATCTCTTGAACCCGGGGGCGGTGAGTGGGCAGAGGTTGCAGTGAGCCGAGATGGAGCCACTGCACTCTAGCCTGGGTGACAGAGCCAGACTCTGACTCAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGAAAAAAATTAAGAAAAGATAATCCATTTGGCTCTTGTGGAGAGAGCAGAATCAGGAGACTAGGAGGTAGATGACTGCTCTAGTCCAGGTTCATTGCAGAGGAGGAGGAGAGAAGGGGGCCAAATCAGTATCTCTATGGTGGGTCTGTGTGCACAATAGATGTGCTCAAATGCAGATTCCTGGGCCCCACCCTCAGAGAGTTTCTGAAACCAGCAAAATCTCGCAGAAAAGAGAACAGAAAAAAGAAAGAAATCATTAGCTTTCTTGGTCATTGGTGATTGAAAAACCAATATTACCTTCAGGAATGGCTGGATGTAGGTGCTCAAACCATTCCATCAGGAAACTCTCCATCTCTTGGCTCTGTACTCCCACATGTGGGCTTCCTTCTAGACAAGCCCTCATGTAGCAAGGTTGCCATCTAGCAGATCTCAGCTTACATTCTATGAGCTTAGCAATTCTTACAGGAAAAGAGTGAAAATTCCAAGGGCTAACTCACTGGAGCAACTTGGGTTACATACTGCCCCGGTTGCTGCACATGGAAGGAAATCTAGCCTTTGTAGGATAAAAAGGAAATAGATATTGAGAAACTGAAATACCAATGCCAATTACAGTAAATCTGGCAGAGGGGCAGAGGCAGTGGCCAACACTTTGGGAAGCTGAGGCAGGAGGATCCTTTGAACCCAAGAGTTGGAGACCAGCTTGGGCAACACAATGAAACTCGTTTCTACAAAAAACTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGACTGCAGTGGTGCGATCTTGGATCTCTGCAACCTCTGCCTCCCAGGTTCAAGCCATTCTTCTGCCTTAGCCTCCCGAGTAGCTGGGATTACAGCCGTCTGCCAACAAGCCAGGCTAACTTTAGTATTCTTTTTTCAGAGATGGGGTTTCACCATGTTGACCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCTTCCCAAAGTGCTGGGATTTCAGGCGTGAGCTACCATGCCCAGCCTTGAACAATTTTTTAAAAATCAGCTGGGCATGGTGGCTCACATCTGTAGTCCCAGCTACTCAGGAGGCTGAAGCAGGAGGATTGCTTGAGCTGGGAGGTTGAGGATGCAGTGAGCTGTGATCTTGCCACCGCACTCTAGACTGGGCAATGGAGTAAGACCCTGTCTCAAAAAAAAAAAAAAAAAATCTAGTGAAGACCAAGAATCTGCATCTAAGGCTTCCAGCTCCAAGGTTCAGACACCAGGAGATAGAGGGCTGTGCTTCCAGATGCAGTTGATAAGTGGGTAGCCTTTGTTCCCCAACTAAACCTCACCTCTACCAACAACTGCCTGCATGACCCATCCTTTCTTTGAGTCTCCATCCCTTTGTGTATAAGATGAGCTGATGACACCAACTTTGGAGGATGGCTAAGAGGACAAGAAGAACCCAGTAGAGGACCTGGAGGGAGGGAGGCCCCTCTCAGAGCCTCAGTTTCCCTTATCTATAAAACGGGTACAACATAACATGAGAAGTTGGTGCTATGGTGCATGTCCAGAGAGAGGAATGCCTCCCTTTTTATGCGGGCCCATTTCCTGGCCTGCAGGCGGCGACTGTGCCACCCTGCTGAAGAATATTGGAGCGCTGCCCGTAGAGATGGCCCGCATGTACTTTGCTGAGACGGTGCTAGCCCTGGAGTATTTGCACAACTATGGCATCGTGCACCGCGACCTCAAGCCTGACAAGTGAGCTTTGATCTTTCCCATCACTCCCTCTGTCCCTCGGGAGGCCAGGAGGCAGAATGGACGGGCCTCATCCCTGAGATCCCCACCTGTGCCTACAGCCTCCTTATCACCTCCATGGGTCACATCAAGCTCACAGATTTCGGCCTCTCCAAGATGGGGCTCATGAGCCTCACCACCAACTTATATGAAGGCCACATCGAGAAGGACGCCCGAGAGTTCCTGGACAAACAGGTGTGTGTGCGGGCATGGGGGTCGCTGAGGGTGGAGTGACCCTGCAGGACCTCGGGAACCCAGGGCCTGGTGGGGGGCACAGCTCTCCCTTGAGGGCCCTCCTCTGGCTGGGGCGTGGGCTGACAGCCTGCCCCCAGGTGTGTGGGACCCCAGAGTACATCGCGCCCGAGGTCATCCTGCGTCAAGGCTACGGCAAGCCAGTGGACTGGTGGGCTATGGGGATCATCCTCTACGAGTTCCTGGTGGGCTGTGTGCCCTTCTTCGGAGACACACCAGAGGAGCTATTTGGACAGGTCATCAGTGGTACGTGGCTTGGCAGTGTACAGGGGCAGAGTGTGGTGTGCACGGAGAGATGGACAGGCTCAGGGTTCCAGGGATTTCAAAAGCGACCCCCCAGAGGATCGCTTGCACTCAGGAGGTCAAGGCTGCAGTGAGCCATGATCGTGCCACTGCACTCCAGCTGGGTGACACAGTGAGATCCTGTGTCCAAACAACAACAACAACAAAAACCGCCCCTAAGTTCCGTTTTGTTTTGCAGATGACATCCTGTGGCCCGAGGGGGATGAGGCCCTACCTACGGAGGCCCAACTCCTCATATCCAGCCTCCTGCAGACCAACCCTCTGGTCAGGCTTGGGGCAGGTAAGTCCGCCATGCAGAGGAGCTGAGGGCCCACTGATAGAGAGCAGGCCTCCAAAACCCCAGGCCCAGCCTGTGCTGTGGCCCCGGGGCGGAAGACATGGGGGGCGGGGCTGGGCTGCTGGGTTGGCCATCAGCTGTGGCTGGAATCCCTTCCGTCCCAGGCGGCGCTTTTGAGGTGAAGCAGCACAGTTTCTTTCGAGACCTGGACTGGACAGGGCTGCTGAGGCAGAAGGCCGAGTTCATCCCCCACCTAGAGTCGGAAGATGACACTAGCTACTTTGACAGTGAGCTGGGACACCAGGCACGACCTGGGTCGAGGGGTGGGATCCGGGAAGAGGGACCCTGGGGTAAGTAAAGCCTGGGATAGGGCCTGGCTAAGTACCAAGATGTGATGCCTAGGTGCGAAGGTGGTATTTTGGTGGGGGCGGGGCCAAGTGGGGCGGGGCTGACATACAGGCGGGGCTCAGGCTGAAATGTAGGTAAGAACCTGAGATTGGGCTAGGTGTGGGGCCTGGCCTGGGTGAGTTGTGAGTGTGGGCCTGGAACTGAACTAGAGAGAGGTACTAGCGCTCAGAATGGCCTGGGGTGATGCCAGGGTGCAGAGCACTGTAGGTGGAGCGTGGCCTCTTTGGAGGCGGGGCTAGACGGTGCCACTGAGAATGGGGCAAGGACCTTGCCTGGGAGCGGAGCCTAAATTAAATACACTAATGAGGCAGGGGCGTGGCCTGACCTGAAGACTTGTAAACCCGTCTTGAACCAGGACTGGGCTCCTGTGGGGATGTGATATGAGGAGGAACCCCGTACCCTCAGTCACAGCCCATACCCGCTCCCCAGCCCGCTCAGACAGGTATCACCACGTGAACTCCTATGACGAGGATGACACGACGGAGGAGGAGCCCGTGGAAATCCGCCAGTTCTCTTCCTGCTCTCCGCGCTTCAGCAAGGTGGGCCAAGTCTGGGTGTGGGACAGGGCGAGACCCCAGGAGGGATGGGGCTTGGAGAGACAGTGAGAAACAGGTTCCCTGGTGCCCAAGGTCTCAGGAGCGGGAAGTTATTGATGGGGCGGGAGTCTGGAAGGTGGTAAGGCCACGCAAGAGGCAGGTTCGGGAGTCTATGGGACGGGCCTTTGGCACTGAGTGGAATCTAACAGGAATCAGGACAGTTGTGCAGATTGAGGCCATGGTGGGGCGGGGCTAGGTGTGGGTGGGGCGGGGTCAGGACGTGGGAATGAGGCCAGCAGCGAAGGCGGAGTAAAGCCCAGCGAAGTCTTGCTTTTATTTATTTATTTTTATTTTTTCTAATAACGGGCAGAGAAGCC
CGGGAGGCTGAGGAACAAGAATCTCTTGAACCCGGGGGCGGTGAGTGGGCAGAGGTTGCAGTGAGCCGAGATGGAGCCACTGCACTCTAGCCTGGGTGACAGAGCCAGACTCTGACTCAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGAAAAAAATTAAGAAAAGATAATCCATTTGGCTCTTGTGGAGAGAGCAGAATCAGGAGACTAGGAGGTAGATGACTGCTCTAGTCCAGGTTCATTGCAGAGGAGGAGGAGAGAAGGGGGCCAAATCAGTATCTCTATGGTGGGTCTGTGTGCACAATAGATGTGCTCAAATGCAGATTCCTGGGCCCCACCCTCAGAGAGTTTCTGAAACCAGCAAAATCTCGCAGAAAAGAGAACAGAAAAAAGAAAGAAATCATTAGCTTTCTTGGTCATTGGTGATTGAAAAACCAATATTACCTTCAGGAATGGCTGGATGTAGGTGCTCAAACCATTCCATCAGGAAACTCTCCATCTCTTGGCTCTGTACTCCCACATGTGGGCTTCCTTCTAGACAAGCCCTCATGTAGCAAGGTTGCCATCTAGCAGATCTCAGCTTACATTCTATGAGCTTAGCAATTCTTACAGGAAAAGAGTGAAAATTCCAAGGGCTAACTCACTGGAGCAACTTGGGTTACATACTGCCCCGGTTGCTGCACATGGAAGGAAATCTAGCCTTTGTAGGATAAAAAGGAAATAGATATTGAGAAACTGAAATACCAATGCCAATTACAGTAAATCTGGCAGAGGGGCAGAGGCAGTGGCCAACACTTTGGGAAGCTGAGGCAGGAGGATCCTTTGAACCCAAGAGTTGGAGACCAGCTTGGGCAACACAATGAAACTCGTTTCTACAAAAAACTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGACTGCAGTGGTGCGATCTTGGATCTCTGCAACCTCTGCCTCCCAGGTTCAAGCCATTCTTCTGCCTTAGCCTCCCGAGTAGCTGGGATTACAGCCGTCTGCCAACAAGCCAGGCTAACTTTAGTATTCTTTTTTCAGAGATGGGGTTTCACCATGTTGACCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCTTCCCAAAGTGCTGGGATTTCAGGCGTGAGCTACCATGCCCAGCCTTGAACAATTTTTTAAAAATCAGCTGGGCATGGTGGCTCACATCTGTAGTCCCAGCTACTCAGGAGGCTGAAGCAGGAGGATTGCTTGAGCTGGGAGGTTGAGGATGCAGTGAGCTGTGATCTTGCCACCGCACTCTAGACTGGGCAATGGAGTAAGACCCTGTCTCAAAAAAAAAAAAAAAAAATCTAGTGAAGACCAAGAATCTGCATCTAAGGCTTCCAGCTCCAAGGTTCAGACACCAGGAGATAGAGGGCTGTGCTTCCAGATGCAGTTGATAAGTGGGTAGCCTTTGTTCCCCAACTAAACCTCACCTCTACCAACAACTGCCTGCATGACCCATCCTTTCTTTGAGTCTCCATCCCTTTGTGTATAAGATGAGCTGATGACACCAACTTTGGAGGATGGCTAAGAGGACAAGAAGAACCCAGTAGAGGACCTGGAGGGAGGGAGGCCCCTCTCAGAGCCTCAGTTTCCCTTATCTATAAAACGGGTACAACATAACATGAGAAGTTGGTGCTATGGTGCATGTCCAGAGAGAGGAATGCCTCCCTTTTTATGCGGGCCCATTTCCTGGCCTGCAGGCGGCGACTGTGCCACCCTGCTGAAGAATATTGGAGCGCTGCCCGTAGAGATGGCCCGCATGTACTTTGCTGAGACGGTGCTAGCCCTGGAGTATTTGCACAACTATGGCATCGTGCACCGCGACCTCAAGCCTGACAAGTGAGCTTTGATCTTTCCCATCACTCCCTCTGTCCCTCGGGAGGCCAGGAGGCAGAATGGACGGGCCTCATCCCTGAGATCCCCACCTGTGCCTACAGCCTCCTTATCACCTCCATGGGTCACATCAAGCTCACAGATTTCAGCCTCTCCAAGATGGGGCTCATGAGCCTCACCACCAACTTATATGAAGGCCACATCGAGAAGGACGCCCGAGAGTTCCTGGACAAACAGGTGTGTGTGCGGGCATGGGGGTCGCTGAGGGTGGAGTGACCCTGCAGGACCTCGGGAACCCAGGGCCTGGTGGGGGGCACAGCTCTCCCTTGAGGGCCCTCCTCTGGCTGGGGCGTGGGCTGACAGCCTGCCCCCAGGTGTGTGGGACCCCAGAGTACATCGCGCCCGAGGTCATCCTGCGTCAAGGCTACGGCAAGCCAGTGGACTGGTGGGCTATGGGGATCATCCTCTACGAGTTCCTGGTGGGCTGTGTGCCCTTCTTCGGAGACACACCAGAGGAGCTATTTGGACAGGTCATCAGTGGTACGTGGCTTGGCAGTGTACAGGGGCAGAGTGTGGTGTGCACGGAGAGATGGACAGGCTCAGGGTTCCAGGGATTTCAAAAGCGACCCCCCAGAGGATCGCTTGCACTCAGGAGGTCAAGGCTGCAGTGAGCCATGATCGTGCCACTGCACTCCAGCTGGGTGACACAGTGAGATCCTGTGTCCAAACAACAACAACAACAAAAACCGCCCCTAAGTTCCGTTTTGTTTTGCAGATGACATCCTGTGGCCCGAGGGGGATGAGGCCCTACCTACGGAGGCCCAACTCCTCATATCCAGCCTCCTGCAGACCAACCCTCTGGTCAGGCTTGGGGCAGGTAAGTCCGCCATGCAGAGGAGCTGAGGGCCCACTGATAGAGAGCAGGCCTCCAAAACCCCAGGCCCAGCCTGTGCTGTGGCCCCGGGGCGGAAGACATGGGGGGCGGGGCTGGGCTGCTGGGTTGGCCATCAGCTGTGGCTGGAATCCCTTCCGTCCCAGGCGGCGCTTTTGAGGTGAAGCAGCACAGTTTCTTTCGAGACCTGGACTGGACAGGGCTGCTGAGGCAGAAGGCCGAGTTCATCCCCCACCTAGAGTCGGAAGATGACACTAGCTACTTTGACAGTGAGCTGGGACACCAGGCACGACCTGGGTCGAGGGGTGGGATCCGGGAAGAGGGACCCTGGGGTAAGTAAAGCCTGGGATAGGGCCTGGCTAAGTACCAAGATGTGATGCCTAGGTGCGAAGGTGGTATTTTGGTGGGGGCGGGGCCAAGTGGGGCGGGGCTGACATACAGGCGGGGCTCAGGCTGAAATGTAGGTAAGAACCTGAGATTGGGCTAGGTGTGGGGCCTGGCCTGGGTGAGTTGTGAGTGTGGGCCTGGAACTGAACTAGAGAGAGGTACTAGCGCTCAGAATGGCCTGGGGTGATGCCAGGGTGCAGAGCACTGTAGGTGGAGCGTGGCCTCTTTGGAGGCGGGGCTAGACGGTGCCACTGAGAATGGGGCAAGGACCTTGCCTGGGAGCGGAGCCTAAATTAAATACACTAATGAGGCAGGGGCGTGGCCTGACCTGAAGACTTGTAAACCCGTCTTGAACCAGGACTGGGCTCCTGTGGGGATGTGATATGAGGAGGAACCCCGTACCCTCAGTCACAGCCCATACCCGCTCCCCAGCCCGCTCAGACAGGTATCACCACGTGAACTCCTATGACGAGGATGACACGACGGAGGAGGAGCCCGTGGAAATCCGCCAGTTCTCTTCCTGCTCTCCGCGCTTCAGCAAGGTGGGCCAAGTCTGGGTGTGGGACAGGGCGAGACCCCAGGAGGGATGGGGCTTGGAGAGACAGTGAGAAACAGGTTCCCTGGTGCCCAAGGTCTCAGGAGCGGGAAGTTATTGATGGGGCGGGAGTCTGGAAGGTGGTAAGGCCACGCAAGAGGCAGGTTCGGGAGTCTATGGGACGGGCCTTTGGCACTGAGTGGAATCTAACAGGAATCAGGACAGTTGTGCAGATTGAGGCCATGGTGGGGCGGGGCTAGGTGTGGGTGGGGCGGGGTCAGGACGTGGGAATGAGGCCAGCAGCGAAGGCGGAGTAAAGCCCAGCGAAGTCTTGCTTTTATTTATTTATTTTTATTTTTTCTAATAACGGGCAGAGAAGCC
Task1_train_26568
Assess the clinical impact of this variant on gene MAST1 (microtubule associated serine/threonine kinase 1), found on Chromosome 19. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations
AATCTCTTGAACCCGGGGGCGGTGAGTGGGCAGAGGTTGCAGTGAGCCGAGATGGAGCCACTGCACTCTAGCCTGGGTGACAGAGCCAGACTCTGACTCAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGAAAAAAATTAAGAAAAGATAATCCATTTGGCTCTTGTGGAGAGAGCAGAATCAGGAGACTAGGAGGTAGATGACTGCTCTAGTCCAGGTTCATTGCAGAGGAGGAGGAGAGAAGGGGGCCAAATCAGTATCTCTATGGTGGGTCTGTGTGCACAATAGATGTGCTCAAATGCAGATTCCTGGGCCCCACCCTCAGAGAGTTTCTGAAACCAGCAAAATCTCGCAGAAAAGAGAACAGAAAAAAGAAAGAAATCATTAGCTTTCTTGGTCATTGGTGATTGAAAAACCAATATTACCTTCAGGAATGGCTGGATGTAGGTGCTCAAACCATTCCATCAGGAAACTCTCCATCTCTTGGCTCTGTACTCCCACATGTGGGCTTCCTTCTAGACAAGCCCTCATGTAGCAAGGTTGCCATCTAGCAGATCTCAGCTTACATTCTATGAGCTTAGCAATTCTTACAGGAAAAGAGTGAAAATTCCAAGGGCTAACTCACTGGAGCAACTTGGGTTACATACTGCCCCGGTTGCTGCACATGGAAGGAAATCTAGCCTTTGTAGGATAAAAAGGAAATAGATATTGAGAAACTGAAATACCAATGCCAATTACAGTAAATCTGGCAGAGGGGCAGAGGCAGTGGCCAACACTTTGGGAAGCTGAGGCAGGAGGATCCTTTGAACCCAAGAGTTGGAGACCAGCTTGGGCAACACAATGAAACTCGTTTCTACAAAAAACTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGACTGCAGTGGTGCGATCTTGGATCTCTGCAACCTCTGCCTCCCAGGTTCAAGCCATTCTTCTGCCTTAGCCTCCCGAGTAGCTGGGATTACAGCCGTCTGCCAACAAGCCAGGCTAACTTTAGTATTCTTTTTTCAGAGATGGGGTTTCACCATGTTGACCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCTTCCCAAAGTGCTGGGATTTCAGGCGTGAGCTACCATGCCCAGCCTTGAACAATTTTTTAAAAATCAGCTGGGCATGGTGGCTCACATCTGTAGTCCCAGCTACTCAGGAGGCTGAAGCAGGAGGATTGCTTGAGCTGGGAGGTTGAGGATGCAGTGAGCTGTGATCTTGCCACCGCACTCTAGACTGGGCAATGGAGTAAGACCCTGTCTCAAAAAAAAAAAAAAAAAATCTAGTGAAGACCAAGAATCTGCATCTAAGGCTTCCAGCTCCAAGGTTCAGACACCAGGAGATAGAGGGCTGTGCTTCCAGATGCAGTTGATAAGTGGGTAGCCTTTGTTCCCCAACTAAACCTCACCTCTACCAACAACTGCCTGCATGACCCATCCTTTCTTTGAGTCTCCATCCCTTTGTGTATAAGATGAGCTGATGACACCAACTTTGGAGGATGGCTAAGAGGACAAGAAGAACCCAGTAGAGGACCTGGAGGGAGGGAGGCCCCTCTCAGAGCCTCAGTTTCCCTTATCTATAAAACGGGTACAACATAACATGAGAAGTTGGTGCTATGGTGCATGTCCAGAGAGAGGAATGCCTCCCTTTTTATGCGGGCCCATTTCCTGGCCTGCAGGCGGCGACTGTGCCACCCTGCTGAAGAATATTGGAGCGCTGCCCGTAGAGATGGCCCGCATGTACTTTGCTGAGACGGTGCTAGCCCTGGAGTATTTGCACAACTATGGCATCGTGCACCGCGACCTCAAGCCTGACAAGTGAGCTTTGATCTTTCCCATCACTCCCTCTGTCCCTCGGGAGGCCAGGAGGCAGAATGGACGGGCCTCATCCCTGAGATCCCCACCTGTGCCTACAGCCTCCTTATCACCTCCATGGGTCACATCAAGCTCACAGATTTCGGCCTCTCCAAGATGGGGCTCATGAGCCTCACCACCAACTTATATGAAGGCCACATCGAGAAGGACGCCCGAGAGTTCCTGGACAAACAGGTGTGTGTGCGGGCATGGGGGTCGCTGAGGGTGGAGTGACCCTGCAGGACCTCGGGAACCCAGGGCCTGGTGGGGGGCACAGCTCTCCCTTGAGGGCCCTCCTCTGGCTGGGGCGTGGGCTGACAGCCTGCCCCCAGGTGTGTGGGACCCCAGAGTACATCGCGCCCGAGGTCATCCTGCGTCAAGGCTACGGCAAGCCAGTGGACTGGTGGGCTATGGGGATCATCCTCTACGAGTTCCTGGTGGGCTGTGTGCCCTTCTTCGGAGACACACCAGAGGAGCTATTTGGACAGGTCATCAGTGGTACGTGGCTTGGCAGTGTACAGGGGCAGAGTGTGGTGTGCACGGAGAGATGGACAGGCTCAGGGTTCCAGGGATTTCAAAAGCGACCCCCCAGAGGATCGCTTGCACTCAGGAGGTCAAGGCTGCAGTGAGCCATGATCGTGCCACTGCACTCCAGCTGGGTGACACAGTGAGATCCTGTGTCCAAACAACAACAACAACAAAAACCGCCCCTAAGTTCCGTTTTGTTTTGCAGATGACATCCTGTGGCCCGAGGGGGATGAGGCCCTACCTACGGAGGCCCAACTCCTCATATCCAGCCTCCTGCAGACCAACCCTCTGGTCAGGCTTGGGGCAGGTAAGTCCGCCATGCAGAGGAGCTGAGGGCCCACTGATAGAGAGCAGGCCTCCAAAACCCCAGGCCCAGCCTGTGCTGTGGCCCCGGGGCGGAAGACATGGGGGGCGGGGCTGGGCTGCTGGGTTGGCCATCAGCTGTGGCTGGAATCCCTTCCGTCCCAGGCGGCGCTTTTGAGGTGAAGCAGCACAGTTTCTTTCGAGACCTGGACTGGACAGGGCTGCTGAGGCAGAAGGCCGAGTTCATCCCCCACCTAGAGTCGGAAGATGACACTAGCTACTTTGACAGTGAGCTGGGACACCAGGCACGACCTGGGTCGAGGGGTGGGATCCGGGAAGAGGGACCCTGGGGTAAGTAAAGCCTGGGATAGGGCCTGGCTAAGTACCAAGATGTGATGCCTAGGTGCGAAGGTGGTATTTTGGTGGGGGCGGGGCCAAGTGGGGCGGGGCTGACATACAGGCGGGGCTCAGGCTGAAATGTAGGTAAGAACCTGAGATTGGGCTAGGTGTGGGGCCTGGCCTGGGTGAGTTGTGAGTGTGGGCCTGGAACTGAACTAGAGAGAGGTACTAGCGCTCAGAATGGCCTGGGGTGATGCCAGGGTGCAGAGCACTGTAGGTGGAGCGTGGCCTCTTTGGAGGCGGGGCTAGACGGTGCCACTGAGAATGGGGCAAGGACCTTGCCTGGGAGCGGAGCCTAAATTAAATACACTAATGAGGCAGGGGCGTGGCCTGACCTGAAGACTTGTAAACCCGTCTTGAACCAGGACTGGGCTCCTGTGGGGATGTGATATGAGGAGGAACCCCGTACCCTCAGTCACAGCCCATACCCGCTCCCCAGCCCGCTCAGACAGGTATCACCACGTGAACTCCTATGACGAGGATGACACGACGGAGGAGGAGCCCGTGGAAATCCGCCAGTTCTCTTCCTGCTCTCCGCGCTTCAGCAAGGTGGGCCAAGTCTGGGTGTGGGACAGGGCGAGACCCCAGGAGGGATGGGGCTTGGAGAGACAGTGAGAAACAGGTTCCCTGGTGCCCAAGGTCTCAGGAGCGGGAAGTTATTGATGGGGCGGGAGTCTGGAAGGTGGTAAGGCCACGCAAGAGGCAGGTTCGGGAGTCTATGGGACGGGCCTTTGGCACTGAGTGGAATCTAACAGGAATCAGGACAGTTGTGCAGATTGAGGCCATGGTGGGGCGGGGCTAGGTGTGGGTGGGGCGGGGTCAGGACGTGGGAATGAGGCCAGCAGCGAAGGCGGAGTAAAGCCCAGCGAAGTCTTGCTTTTATTTATTTATTTTTATTTTTTCTAATAACGGGCAGAGAAGCCATAGGCCTTGCTTTGAGAA
AATCTCTTGAACCCGGGGGCGGTGAGTGGGCAGAGGTTGCAGTGAGCCGAGATGGAGCCACTGCACTCTAGCCTGGGTGACAGAGCCAGACTCTGACTCAAAAAAAAAAAAAAAAAAAAAAAGAGAAAAAGAAAAAAATTAAGAAAAGATAATCCATTTGGCTCTTGTGGAGAGAGCAGAATCAGGAGACTAGGAGGTAGATGACTGCTCTAGTCCAGGTTCATTGCAGAGGAGGAGGAGAGAAGGGGGCCAAATCAGTATCTCTATGGTGGGTCTGTGTGCACAATAGATGTGCTCAAATGCAGATTCCTGGGCCCCACCCTCAGAGAGTTTCTGAAACCAGCAAAATCTCGCAGAAAAGAGAACAGAAAAAAGAAAGAAATCATTAGCTTTCTTGGTCATTGGTGATTGAAAAACCAATATTACCTTCAGGAATGGCTGGATGTAGGTGCTCAAACCATTCCATCAGGAAACTCTCCATCTCTTGGCTCTGTACTCCCACATGTGGGCTTCCTTCTAGACAAGCCCTCATGTAGCAAGGTTGCCATCTAGCAGATCTCAGCTTACATTCTATGAGCTTAGCAATTCTTACAGGAAAAGAGTGAAAATTCCAAGGGCTAACTCACTGGAGCAACTTGGGTTACATACTGCCCCGGTTGCTGCACATGGAAGGAAATCTAGCCTTTGTAGGATAAAAAGGAAATAGATATTGAGAAACTGAAATACCAATGCCAATTACAGTAAATCTGGCAGAGGGGCAGAGGCAGTGGCCAACACTTTGGGAAGCTGAGGCAGGAGGATCCTTTGAACCCAAGAGTTGGAGACCAGCTTGGGCAACACAATGAAACTCGTTTCTACAAAAAACTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGACTGCAGTGGTGCGATCTTGGATCTCTGCAACCTCTGCCTCCCAGGTTCAAGCCATTCTTCTGCCTTAGCCTCCCGAGTAGCTGGGATTACAGCCGTCTGCCAACAAGCCAGGCTAACTTTAGTATTCTTTTTTCAGAGATGGGGTTTCACCATGTTGACCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCTTCCCAAAGTGCTGGGATTTCAGGCGTGAGCTACCATGCCCAGCCTTGAACAATTTTTTAAAAATCAGCTGGGCATGGTGGCTCACATCTGTAGTCCCAGCTACTCAGGAGGCTGAAGCAGGAGGATTGCTTGAGCTGGGAGGTTGAGGATGCAGTGAGCTGTGATCTTGCCACCGCACTCTAGACTGGGCAATGGAGTAAGACCCTGTCTCAAAAAAAAAAAAAAAAAATCTAGTGAAGACCAAGAATCTGCATCTAAGGCTTCCAGCTCCAAGGTTCAGACACCAGGAGATAGAGGGCTGTGCTTCCAGATGCAGTTGATAAGTGGGTAGCCTTTGTTCCCCAACTAAACCTCACCTCTACCAACAACTGCCTGCATGACCCATCCTTTCTTTGAGTCTCCATCCCTTTGTGTATAAGATGAGCTGATGACACCAACTTTGGAGGATGGCTAAGAGGACAAGAAGAACCCAGTAGAGGACCTGGAGGGAGGGAGGCCCCTCTCAGAGCCTCAGTTTCCCTTATCTATAAAACGGGTACAACATAACATGAGAAGTTGGTGCTATGGTGCATGTCCAGAGAGAGGAATGCCTCCCTTTTTATGCGGGCCCATTTCCTGGCCTGCAGGCGGCGACTGTGCCACCCTGCTGAAGAATATTGGAGCGCTGCCCGTAGAGATGGCCCGCATGTACTTTGCTGAGACGGTGCTAGCCCTGGAGTATTTGCACAACTATGGCATCGTGCACCGCGACCTCAAGCCTGACAAGTGAGCTTTGATCTTTCCCATCACTCCCTCTGTCCCTCGGGAGGCCAGGAGGCAGAATGGACGGGCCTCATCCCTGAGATCCCCACCTGTGCCTACAGCCTCCTTATCACCTCCATGGGTCACATCAAGCTCACAGATTTCGGCCTCTCCAAGATGGGGCCCATGAGCCTCACCACCAACTTATATGAAGGCCACATCGAGAAGGACGCCCGAGAGTTCCTGGACAAACAGGTGTGTGTGCGGGCATGGGGGTCGCTGAGGGTGGAGTGACCCTGCAGGACCTCGGGAACCCAGGGCCTGGTGGGGGGCACAGCTCTCCCTTGAGGGCCCTCCTCTGGCTGGGGCGTGGGCTGACAGCCTGCCCCCAGGTGTGTGGGACCCCAGAGTACATCGCGCCCGAGGTCATCCTGCGTCAAGGCTACGGCAAGCCAGTGGACTGGTGGGCTATGGGGATCATCCTCTACGAGTTCCTGGTGGGCTGTGTGCCCTTCTTCGGAGACACACCAGAGGAGCTATTTGGACAGGTCATCAGTGGTACGTGGCTTGGCAGTGTACAGGGGCAGAGTGTGGTGTGCACGGAGAGATGGACAGGCTCAGGGTTCCAGGGATTTCAAAAGCGACCCCCCAGAGGATCGCTTGCACTCAGGAGGTCAAGGCTGCAGTGAGCCATGATCGTGCCACTGCACTCCAGCTGGGTGACACAGTGAGATCCTGTGTCCAAACAACAACAACAACAAAAACCGCCCCTAAGTTCCGTTTTGTTTTGCAGATGACATCCTGTGGCCCGAGGGGGATGAGGCCCTACCTACGGAGGCCCAACTCCTCATATCCAGCCTCCTGCAGACCAACCCTCTGGTCAGGCTTGGGGCAGGTAAGTCCGCCATGCAGAGGAGCTGAGGGCCCACTGATAGAGAGCAGGCCTCCAAAACCCCAGGCCCAGCCTGTGCTGTGGCCCCGGGGCGGAAGACATGGGGGGCGGGGCTGGGCTGCTGGGTTGGCCATCAGCTGTGGCTGGAATCCCTTCCGTCCCAGGCGGCGCTTTTGAGGTGAAGCAGCACAGTTTCTTTCGAGACCTGGACTGGACAGGGCTGCTGAGGCAGAAGGCCGAGTTCATCCCCCACCTAGAGTCGGAAGATGACACTAGCTACTTTGACAGTGAGCTGGGACACCAGGCACGACCTGGGTCGAGGGGTGGGATCCGGGAAGAGGGACCCTGGGGTAAGTAAAGCCTGGGATAGGGCCTGGCTAAGTACCAAGATGTGATGCCTAGGTGCGAAGGTGGTATTTTGGTGGGGGCGGGGCCAAGTGGGGCGGGGCTGACATACAGGCGGGGCTCAGGCTGAAATGTAGGTAAGAACCTGAGATTGGGCTAGGTGTGGGGCCTGGCCTGGGTGAGTTGTGAGTGTGGGCCTGGAACTGAACTAGAGAGAGGTACTAGCGCTCAGAATGGCCTGGGGTGATGCCAGGGTGCAGAGCACTGTAGGTGGAGCGTGGCCTCTTTGGAGGCGGGGCTAGACGGTGCCACTGAGAATGGGGCAAGGACCTTGCCTGGGAGCGGAGCCTAAATTAAATACACTAATGAGGCAGGGGCGTGGCCTGACCTGAAGACTTGTAAACCCGTCTTGAACCAGGACTGGGCTCCTGTGGGGATGTGATATGAGGAGGAACCCCGTACCCTCAGTCACAGCCCATACCCGCTCCCCAGCCCGCTCAGACAGGTATCACCACGTGAACTCCTATGACGAGGATGACACGACGGAGGAGGAGCCCGTGGAAATCCGCCAGTTCTCTTCCTGCTCTCCGCGCTTCAGCAAGGTGGGCCAAGTCTGGGTGTGGGACAGGGCGAGACCCCAGGAGGGATGGGGCTTGGAGAGACAGTGAGAAACAGGTTCCCTGGTGCCCAAGGTCTCAGGAGCGGGAAGTTATTGATGGGGCGGGAGTCTGGAAGGTGGTAAGGCCACGCAAGAGGCAGGTTCGGGAGTCTATGGGACGGGCCTTTGGCACTGAGTGGAATCTAACAGGAATCAGGACAGTTGTGCAGATTGAGGCCATGGTGGGGCGGGGCTAGGTGTGGGTGGGGCGGGGTCAGGACGTGGGAATGAGGCCAGCAGCGAAGGCGGAGTAAAGCCCAGCGAAGTCTTGCTTTTATTTATTTATTTTTATTTTTTCTAATAACGGGCAGAGAAGCCATAGGCCTTGCTTTGAGAA
Task1_train_26569
A genomic change on Chromosome 19 affects DNASE2 (deoxyribonuclease 2, lysosomal). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Autoinflammatory-pancytopenia syndrome due to DNASE2 deficiency
GCTCAGTTGTCAATTCCCAGTCCTGGGAATGATGACATTAATATTAATTGCCCTTCCCAAATTTGTTTTTGAGACAGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTAATCTCGGCACACTGCAACCTCTGCCTCCTGGTTTCAAGCGATTCTCATGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCCCGCCACCACACCCGGCTAATTTTTGTACTTTTAGTAGAGATGGGGTTCCACCATGTTGGCCAGGCTGTTCTCAAACTCCTGACCGTGTAATCAGCCAGCGCCCTCCACCATGCCCAGATAATTTTTGTACTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGACTGGTCTTGAACTCCTGGGCTCAAGTGACCCACCCGCCTTGGTCTCCCAAAATGTGGGGATTACAGGTGAGCCACCGCGTCCGGCCCTGAGTGTTTTTAATTAATTAACTTATTTATTTTGAGACTGGGTCTCATTTTGACACCCCAGCTGGAGTGCAGTGGCAGGATCATGACTCACTTGCAGCCTCGACCTCCTGGGCTCAAGCTGTTCTCCCACCTCAGCCTCCTGAGTAGTGGGGACTACACGTGTGTGCCACTATGCCCCACTAATTAAAATTTTTTTTGTAGAGATGGGGTCCCGCTGTGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCAATCCTCCTGCCTCGACTGGGATTACAGGTGTGAGCCACTGTGCCTGGCCTATTTATTTGTATTTATTTATTTATTTATTTATTTTGAGACACAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACTATCTTGACTCACTGCAAGCTCCACCTTCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAACTGGGACTACAGGTGCCCGCCACCATGCCTGGCTAATTTTTGCACTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGAGCTCGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCAGCCTATTTATTTATTTTTAAATAAAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGAGTCATTATAGCTCACTGCAGTCTGAAACTCTGGGCTCAATTTATCCTCCTGCCTCAGCCTCCCAAGTTGCTTGGCTAATTTTTAATTTTGTAGAGATGAGGTCTTGCTATGTTTCCCAGGCTTGTCTTGGATGCCTGTCTTCAAATGATCCTCCTGCCTCAGCCTCCTAAGTAACTGGGATTACAGGAGTGAGGCACCACCTCTGGCACCCAAATGACTTACAGGTACCACTTCATTCACAATTTTTTAAGTAGATGTCAGTATCCCCATTTTTCAGATGAGTAGACCAAGGCTCAGGTGAAGTTATACATCACACAGCAAAACCCAGGGTTTGAACCCAGGTCTGTTCACTGATCATGTGATTATAGCTCCCAAACAGACCTGGTCTCTACCGCTGACTTGAACTCAGCCATGGCCACACCAGTCACCCTGTCTGCAGAGAAGGAGCTCTCCAACCCTCAACCTTGAGACTCACCATCTCCAAATTTGCTGAACTTGGCAAAGCTCTGGAAAACAGCCCCGGCCTGGGATGTGAGTGTGATGCTGCTGTTCCAGGGTTCTTGGCTAACGTGGTGGCCCTTGACCACATTCTCCAAGTCGGGGAATTCCTGGGCAAAGATCCCTTCCAGCTGGTAGTTATAGACCCAGGGGTAGGTGTAGGTCAGCTGCTTGCCTGGAGGACAAGGGGAGGAGGAAATGCAAGATCGTTCCAGGTTCTGGTCAGTAAACCCAGGACTCATCCTGTGTCCCTGACTCGACTTACCCATCTTCGAGAACTGAGCGAAGGGAAAAGACACACAGAGCAGGGTCTGCCCGTAGGTACAGGCGCTATGAGGCCAGCTGTATGCAGCAGAGGAGGCCGGTGGAGGGAAGTTAGGTACACTGTGGACCAGCCAGAAGCCCCCATCGTGGTCAAGGAGCAGGACACCTGGACCAAAAGAAGGCATTAGGGGAGGTCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGACACACAGATCACCTGAGGTCAGGAGTTAGAAATCAGCCTGGCCAACATGGCGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGAGCGTGGTGGTGGACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCCACCACTGCACTCCAGCCTGGGCCACAGAGCAAAATTTCATCTCAAACATAAGTAAGTAAGTAAGTAAATAAATAAATAAATAAATAAATAAATAAAAATTTAAAAAAAGAAGGCAGGCCCCACGCAGTGTAATCCCAGCACTTTGGGAAGCCGAGGAGGGCGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGGCCAACATGGAGAAACCTCATCACTACTAAAAATACAACATTAGCCGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGATGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCATTGCACTCCAGCCTGGGTAGCAAGAGCAAAACTCCTTCTCAAAAAAAAAAAAAAAAAAAAGGCAATTAGAGGGTATTGCTCCAGGCCTCCCAGCAAGCTCATCTGCAATCAGGAACACCCTCAGTTTGCAGCGGGGCTTAGAGAGGGTGCCAGCAGTGTTAGAACCACAGCTGAGCTCAGTTTTTGCAGGCATAAATTCTTATAGTCCAGAATAACGCCAAGAGTAATGTAAGGTAGGGAAACAGGCCAGGTGTGGCGGCTCATGCCGGTAATCGCAGCACATTAAGAGGCCAAGGTGGGTGGATTGCTTGAACCAGGACTTAGAGACCAGCCTAGGCAACATGGCAAAAGCCCACTCTACAAAAATACAAAAAGTAGGCCAGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAATATCAGCCTGTCCAACCTGGTAAAACCCCATCTCTACTAAAACATACAACATTTAGCTGGGCATGGTGGCGCACACCTGTAATCCCAGCTACTCCAGAGGCTGAGGCAGAAGAATCGCTTGAACTGGGGAGATGGAGATTGCAGTGAGCTGAGATTGCACCACCGAACTCCAGCCTGGGTGATGGAGAGAGAGTGCCGCAAAAAAAAAAAAAAAAAAAAAAAGCCAGGCGTGGTGGGGGGTACCGGCAGGCCCAGTACTTGGGAGGCTGAGGTAGGAGGATCACCTGAGCCCTGGGAGGTCAAGGCTGCAGTGAGCTGTGATACTGCACTCCAGCCTAGGTGACTGGGTGAGACCTTGTCTAAAAGAAAATAAAATAGGGGAAATAGATGCCCAAGGTCTGACAGGGGAGATCTCCCACCCCACTATGGAGGTCAGGGGTTAGCTTGGAAAAATGCATAGGAACTCGGCTGGGCAGGGTGGCTCATTCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTAGATCACTTGAGGTAGAAACCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTCGTCTGTACTAAAAATATGAAAATTAGCCTGGTGTGATGGTGCGCCTTTAATACCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTCAACCCCAGAGGCAGAGATTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCTTGGGTGACAGAGCGAACTCCCACCGTCTCAAAAACAAAGAAAAAAAAAAGTTGGGGGGAATAGATGCCCAGGGTCTGACAGTGCAGATCTCCCCGACCACCCCATGCACGTCAGGGGTTACCTTGGAAAAATGGGACCCGAGTCTCTCCCCAGCCCCCAATCCAGGCCTCACCCTTCGTGTGCCCACGCATGGAAGAGTCCTGAGCCTTGCTGGGTTGAGGCGGTTGGTCATTGTAG
GCTCAGTTGTCAATTCCCAGTCCTGGGAATGATGACATTAATATTAATTGCCCTTCCCAAATTTGTTTTTGAGACAGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTAATCTCGGCACACTGCAACCTCTGCCTCCTGGTTTCAAGCGATTCTCATGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCCCGCCACCACACCCGGCTAATTTTTGTACTTTTAGTAGAGATGGGGTTCCACCATGTTGGCCAGGCTGTTCTCAAACTCCTGACCGTGTAATCAGCCAGCGCCCTCCACCATGCCCAGATAATTTTTGTACTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGACTGGTCTTGAACTCCTGGGCTCAAGTGACCCACCCGCCTTGGTCTCCCAAAATGTGGGGATTACAGGTGAGCCACCGCGTCCGGCCCTGAGTGTTTTTAATTAATTAACTTATTTATTTTGAGACTGGGTCTCATTTTGACACCCCAGCTGGAGTGCAGTGGCAGGATCATGACTCACTTGCAGCCTCGACCTCCTGGGCTCAAGCTGTTCTCCCACCTCAGCCTCCTGAGTAGTGGGGACTACACGTGTGTGCCACTATGCCCCACTAATTAAAATTTTTTTTGTAGAGATGGGGTCCCGCTGTGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCAATCCTCCTGCCTCGACTGGGATTACAGGTGTGAGCCACTGTGCCTGGCCTATTTATTTGTATTTATTTATTTATTTATTTATTTTGAGACACAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACTATCTTGACTCACTGCAAGCTCCACCTTCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAACTGGGACTACAGGTGCCCGCCACCATGCCTGGCTAATTTTTGCACTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGAGCTCGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCAGCCTATTTATTTATTTTTAAATAAAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGAGTCATTATAGCTCACTGCAGTCTGAAACTCTGGGCTCAATTTATCCTCCTGCCTCAGCCTCCCAAGTTGCTTGGCTAATTTTTAATTTTGTAGAGATGAGGTCTTGCTATGTTTCCCAGGCTTGTCTTGGATGCCTGTCTTCAAATGATCCTCCTGCCTCAGCCTCCTAAGTAACTGGGATTACAGGAGTGAGGCACCACCTCTGGCACCCAAATGACTTACAGGTACCACTTCATTCACAATTTTTTAAGTAGATGTCAGTATCCCCATTTTTCAGATGAGTAGACCAAGGCTCAGGTGAAGTTATACATCACACAGCAAAACCCAGGGTTTGAACCCAGGTCTGTTCACTGATCATGTGATTATAGCTCCCAAACAGACCTGGTCTCTACCGCTGACTTGAACTCAGCCATGGCCACACCAGTCACCCTGTCTGCAGAGAAGGAGCTCTCCAACCCTCAACCTTGAGACTCACCATCTCCAAATTTGCTGAACTTGGCAAAGCTCTGGAAAACAGCCCCGGCCTGGGATGTGAGTGTGATGCTGCTGTTCCAGGGTTCTTGGCTAACGTGGTGGCCCTTGACCACATTCTCCAAGTCGGGGAATTCCTGGGCAAAGATCCCTTCCAGCTGGTAGTTATAGACCCAGGGGTAGGTGTAGGTCAGCTGCTTGCCTGGAGGACAAGGGGAGGAGGAAATGCAAGATCGTTCCAGGTTCTGGTCAGTAAACCCAGGACTCATCCTGTGTCCCTGACTCGACTTACCCATCTTCGAGAACTGAGCGAAGGGAAAAGACACACAGAGCAGGGTCTGCCCGTAGGTACAGGCGCTATGAGGCCAGCTGTATGCAGCAGAGGAGGCCGGTGGAGGGAAGTTAGGTACACTGTGGACCAGCCAGAAGCCCCCATCGTGGACAAGGAGCAGGACACCTGGACCAAAAGAAGGCATTAGGGGAGGTCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGACACACAGATCACCTGAGGTCAGGAGTTAGAAATCAGCCTGGCCAACATGGCGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGAGCGTGGTGGTGGACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCCACCACTGCACTCCAGCCTGGGCCACAGAGCAAAATTTCATCTCAAACATAAGTAAGTAAGTAAGTAAATAAATAAATAAATAAATAAATAAATAAAAATTTAAAAAAAGAAGGCAGGCCCCACGCAGTGTAATCCCAGCACTTTGGGAAGCCGAGGAGGGCGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGGCCAACATGGAGAAACCTCATCACTACTAAAAATACAACATTAGCCGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGATGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCATTGCACTCCAGCCTGGGTAGCAAGAGCAAAACTCCTTCTCAAAAAAAAAAAAAAAAAAAAGGCAATTAGAGGGTATTGCTCCAGGCCTCCCAGCAAGCTCATCTGCAATCAGGAACACCCTCAGTTTGCAGCGGGGCTTAGAGAGGGTGCCAGCAGTGTTAGAACCACAGCTGAGCTCAGTTTTTGCAGGCATAAATTCTTATAGTCCAGAATAACGCCAAGAGTAATGTAAGGTAGGGAAACAGGCCAGGTGTGGCGGCTCATGCCGGTAATCGCAGCACATTAAGAGGCCAAGGTGGGTGGATTGCTTGAACCAGGACTTAGAGACCAGCCTAGGCAACATGGCAAAAGCCCACTCTACAAAAATACAAAAAGTAGGCCAGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAATATCAGCCTGTCCAACCTGGTAAAACCCCATCTCTACTAAAACATACAACATTTAGCTGGGCATGGTGGCGCACACCTGTAATCCCAGCTACTCCAGAGGCTGAGGCAGAAGAATCGCTTGAACTGGGGAGATGGAGATTGCAGTGAGCTGAGATTGCACCACCGAACTCCAGCCTGGGTGATGGAGAGAGAGTGCCGCAAAAAAAAAAAAAAAAAAAAAAAGCCAGGCGTGGTGGGGGGTACCGGCAGGCCCAGTACTTGGGAGGCTGAGGTAGGAGGATCACCTGAGCCCTGGGAGGTCAAGGCTGCAGTGAGCTGTGATACTGCACTCCAGCCTAGGTGACTGGGTGAGACCTTGTCTAAAAGAAAATAAAATAGGGGAAATAGATGCCCAAGGTCTGACAGGGGAGATCTCCCACCCCACTATGGAGGTCAGGGGTTAGCTTGGAAAAATGCATAGGAACTCGGCTGGGCAGGGTGGCTCATTCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTAGATCACTTGAGGTAGAAACCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTCGTCTGTACTAAAAATATGAAAATTAGCCTGGTGTGATGGTGCGCCTTTAATACCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTCAACCCCAGAGGCAGAGATTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCTTGGGTGACAGAGCGAACTCCCACCGTCTCAAAAACAAAGAAAAAAAAAAGTTGGGGGGAATAGATGCCCAGGGTCTGACAGTGCAGATCTCCCCGACCACCCCATGCACGTCAGGGGTTACCTTGGAAAAATGGGACCCGAGTCTCTCCCCAGCCCCCAATCCAGGCCTCACCCTTCGTGTGCCCACGCATGGAAGAGTCCTGAGCCTTGCTGGGTTGAGGCGGTTGGTCATTGTAG
Task1_train_26570
Located on Chromosome 19, this mutation impacts DNASE2 (deoxyribonuclease 2, lysosomal). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Autoinflammatory-pancytopenia syndrome due to DNASE2 deficiency
CCCAGTCCTGGGAATGATGACATTAATATTAATTGCCCTTCCCAAATTTGTTTTTGAGACAGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTAATCTCGGCACACTGCAACCTCTGCCTCCTGGTTTCAAGCGATTCTCATGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCCCGCCACCACACCCGGCTAATTTTTGTACTTTTAGTAGAGATGGGGTTCCACCATGTTGGCCAGGCTGTTCTCAAACTCCTGACCGTGTAATCAGCCAGCGCCCTCCACCATGCCCAGATAATTTTTGTACTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGACTGGTCTTGAACTCCTGGGCTCAAGTGACCCACCCGCCTTGGTCTCCCAAAATGTGGGGATTACAGGTGAGCCACCGCGTCCGGCCCTGAGTGTTTTTAATTAATTAACTTATTTATTTTGAGACTGGGTCTCATTTTGACACCCCAGCTGGAGTGCAGTGGCAGGATCATGACTCACTTGCAGCCTCGACCTCCTGGGCTCAAGCTGTTCTCCCACCTCAGCCTCCTGAGTAGTGGGGACTACACGTGTGTGCCACTATGCCCCACTAATTAAAATTTTTTTTGTAGAGATGGGGTCCCGCTGTGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCAATCCTCCTGCCTCGACTGGGATTACAGGTGTGAGCCACTGTGCCTGGCCTATTTATTTGTATTTATTTATTTATTTATTTATTTTGAGACACAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACTATCTTGACTCACTGCAAGCTCCACCTTCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAACTGGGACTACAGGTGCCCGCCACCATGCCTGGCTAATTTTTGCACTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGAGCTCGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCAGCCTATTTATTTATTTTTAAATAAAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGAGTCATTATAGCTCACTGCAGTCTGAAACTCTGGGCTCAATTTATCCTCCTGCCTCAGCCTCCCAAGTTGCTTGGCTAATTTTTAATTTTGTAGAGATGAGGTCTTGCTATGTTTCCCAGGCTTGTCTTGGATGCCTGTCTTCAAATGATCCTCCTGCCTCAGCCTCCTAAGTAACTGGGATTACAGGAGTGAGGCACCACCTCTGGCACCCAAATGACTTACAGGTACCACTTCATTCACAATTTTTTAAGTAGATGTCAGTATCCCCATTTTTCAGATGAGTAGACCAAGGCTCAGGTGAAGTTATACATCACACAGCAAAACCCAGGGTTTGAACCCAGGTCTGTTCACTGATCATGTGATTATAGCTCCCAAACAGACCTGGTCTCTACCGCTGACTTGAACTCAGCCATGGCCACACCAGTCACCCTGTCTGCAGAGAAGGAGCTCTCCAACCCTCAACCTTGAGACTCACCATCTCCAAATTTGCTGAACTTGGCAAAGCTCTGGAAAACAGCCCCGGCCTGGGATGTGAGTGTGATGCTGCTGTTCCAGGGTTCTTGGCTAACGTGGTGGCCCTTGACCACATTCTCCAAGTCGGGGAATTCCTGGGCAAAGATCCCTTCCAGCTGGTAGTTATAGACCCAGGGGTAGGTGTAGGTCAGCTGCTTGCCTGGAGGACAAGGGGAGGAGGAAATGCAAGATCGTTCCAGGTTCTGGTCAGTAAACCCAGGACTCATCCTGTGTCCCTGACTCGACTTACCCATCTTCGAGAACTGAGCGAAGGGAAAAGACACACAGAGCAGGGTCTGCCCGTAGGTACAGGCGCTATGAGGCCAGCTGTATGCAGCAGAGGAGGCCGGTGGAGGGAAGTTAGGTACACTGTGGACCAGCCAGAAGCCCCCATCGTGGTCAAGGAGCAGGACACCTGGACCAAAAGAAGGCATTAGGGGAGGTCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGACACACAGATCACCTGAGGTCAGGAGTTAGAAATCAGCCTGGCCAACATGGCGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGAGCGTGGTGGTGGACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCCACCACTGCACTCCAGCCTGGGCCACAGAGCAAAATTTCATCTCAAACATAAGTAAGTAAGTAAGTAAATAAATAAATAAATAAATAAATAAATAAAAATTTAAAAAAAGAAGGCAGGCCCCACGCAGTGTAATCCCAGCACTTTGGGAAGCCGAGGAGGGCGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGGCCAACATGGAGAAACCTCATCACTACTAAAAATACAACATTAGCCGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGATGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCATTGCACTCCAGCCTGGGTAGCAAGAGCAAAACTCCTTCTCAAAAAAAAAAAAAAAAAAAAGGCAATTAGAGGGTATTGCTCCAGGCCTCCCAGCAAGCTCATCTGCAATCAGGAACACCCTCAGTTTGCAGCGGGGCTTAGAGAGGGTGCCAGCAGTGTTAGAACCACAGCTGAGCTCAGTTTTTGCAGGCATAAATTCTTATAGTCCAGAATAACGCCAAGAGTAATGTAAGGTAGGGAAACAGGCCAGGTGTGGCGGCTCATGCCGGTAATCGCAGCACATTAAGAGGCCAAGGTGGGTGGATTGCTTGAACCAGGACTTAGAGACCAGCCTAGGCAACATGGCAAAAGCCCACTCTACAAAAATACAAAAAGTAGGCCAGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAATATCAGCCTGTCCAACCTGGTAAAACCCCATCTCTACTAAAACATACAACATTTAGCTGGGCATGGTGGCGCACACCTGTAATCCCAGCTACTCCAGAGGCTGAGGCAGAAGAATCGCTTGAACTGGGGAGATGGAGATTGCAGTGAGCTGAGATTGCACCACCGAACTCCAGCCTGGGTGATGGAGAGAGAGTGCCGCAAAAAAAAAAAAAAAAAAAAAAAGCCAGGCGTGGTGGGGGGTACCGGCAGGCCCAGTACTTGGGAGGCTGAGGTAGGAGGATCACCTGAGCCCTGGGAGGTCAAGGCTGCAGTGAGCTGTGATACTGCACTCCAGCCTAGGTGACTGGGTGAGACCTTGTCTAAAAGAAAATAAAATAGGGGAAATAGATGCCCAAGGTCTGACAGGGGAGATCTCCCACCCCACTATGGAGGTCAGGGGTTAGCTTGGAAAAATGCATAGGAACTCGGCTGGGCAGGGTGGCTCATTCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTAGATCACTTGAGGTAGAAACCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTCGTCTGTACTAAAAATATGAAAATTAGCCTGGTGTGATGGTGCGCCTTTAATACCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTCAACCCCAGAGGCAGAGATTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCTTGGGTGACAGAGCGAACTCCCACCGTCTCAAAAACAAAGAAAAAAAAAAGTTGGGGGGAATAGATGCCCAGGGTCTGACAGTGCAGATCTCCCCGACCACCCCATGCACGTCAGGGGTTACCTTGGAAAAATGGGACCCGAGTCTCTCCCCAGCCCCCAATCCAGGCCTCACCCTTCGTGTGCCCACGCATGGAAGAGTCCTGAGCCTTGCTGGGTTGAGGCGGTTGGTCATTGTAGAGCAGGAAGGCGAGC
CCCAGTCCTGGGAATGATGACATTAATATTAATTGCCCTTCCCAAATTTGTTTTTGAGACAGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTAATCTCGGCACACTGCAACCTCTGCCTCCTGGTTTCAAGCGATTCTCATGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCCCGCCACCACACCCGGCTAATTTTTGTACTTTTAGTAGAGATGGGGTTCCACCATGTTGGCCAGGCTGTTCTCAAACTCCTGACCGTGTAATCAGCCAGCGCCCTCCACCATGCCCAGATAATTTTTGTACTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGACTGGTCTTGAACTCCTGGGCTCAAGTGACCCACCCGCCTTGGTCTCCCAAAATGTGGGGATTACAGGTGAGCCACCGCGTCCGGCCCTGAGTGTTTTTAATTAATTAACTTATTTATTTTGAGACTGGGTCTCATTTTGACACCCCAGCTGGAGTGCAGTGGCAGGATCATGACTCACTTGCAGCCTCGACCTCCTGGGCTCAAGCTGTTCTCCCACCTCAGCCTCCTGAGTAGTGGGGACTACACGTGTGTGCCACTATGCCCCACTAATTAAAATTTTTTTTGTAGAGATGGGGTCCCGCTGTGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCAATCCTCCTGCCTCGACTGGGATTACAGGTGTGAGCCACTGTGCCTGGCCTATTTATTTGTATTTATTTATTTATTTATTTATTTTGAGACACAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACTATCTTGACTCACTGCAAGCTCCACCTTCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAACTGGGACTACAGGTGCCCGCCACCATGCCTGGCTAATTTTTGCACTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGAGCTCGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCAGCCTATTTATTTATTTTTAAATAAAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGAGTCATTATAGCTCACTGCAGTCTGAAACTCTGGGCTCAATTTATCCTCCTGCCTCAGCCTCCCAAGTTGCTTGGCTAATTTTTAATTTTGTAGAGATGAGGTCTTGCTATGTTTCCCAGGCTTGTCTTGGATGCCTGTCTTCAAATGATCCTCCTGCCTCAGCCTCCTAAGTAACTGGGATTACAGGAGTGAGGCACCACCTCTGGCACCCAAATGACTTACAGGTACCACTTCATTCACAATTTTTTAAGTAGATGTCAGTATCCCCATTTTTCAGATGAGTAGACCAAGGCTCAGGTGAAGTTATACATCACACAGCAAAACCCAGGGTTTGAACCCAGGTCTGTTCACTGATCATGTGATTATAGCTCCCAAACAGACCTGGTCTCTACCGCTGACTTGAACTCAGCCATGGCCACACCAGTCACCCTGTCTGCAGAGAAGGAGCTCTCCAACCCTCAACCTTGAGACTCACCATCTCCAAATTTGCTGAACTTGGCAAAGCTCTGGAAAACAGCCCCGGCCTGGGATGTGAGTGTGATGCTGCTGTTCCAGGGTTCTTGGCTAACGTGGTGGCCCTTGACCACATTCTCCAAGTCGGGGAATTCCTGGGCAAAGATCCCTTCCAGCTGGTAGTTATAGACCCAGGGGTAGGTGTAGGTCAGCTGCTTGCCTGGAGGACAAGGGGAGGAGGAAATGCAAGATCGTTCCAGGTTCTGGTCAGTAAACCCAGGACTCATCCTGTGTCCCTGACTCGACTTACCCATCTTCGAGAACTGAGCGAAGGGAAAAGACACACAGAGCAGGGTCTGCCCGTAGGTACAGGCGCTATGAGGCCAGCTGTATGCAGCAGAGGAGGCCGGTGGAGGGAAGTTAGGTACACTGTGGACCAGCCAGAAGCCCCCATCGTGGTCAAGGAGCAGGACAGCTGGACCAAAAGAAGGCATTAGGGGAGGTCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGACACACAGATCACCTGAGGTCAGGAGTTAGAAATCAGCCTGGCCAACATGGCGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGAGCGTGGTGGTGGACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCCACCACTGCACTCCAGCCTGGGCCACAGAGCAAAATTTCATCTCAAACATAAGTAAGTAAGTAAGTAAATAAATAAATAAATAAATAAATAAATAAAAATTTAAAAAAAGAAGGCAGGCCCCACGCAGTGTAATCCCAGCACTTTGGGAAGCCGAGGAGGGCGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGGCCAACATGGAGAAACCTCATCACTACTAAAAATACAACATTAGCCGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGATGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCATTGCACTCCAGCCTGGGTAGCAAGAGCAAAACTCCTTCTCAAAAAAAAAAAAAAAAAAAAGGCAATTAGAGGGTATTGCTCCAGGCCTCCCAGCAAGCTCATCTGCAATCAGGAACACCCTCAGTTTGCAGCGGGGCTTAGAGAGGGTGCCAGCAGTGTTAGAACCACAGCTGAGCTCAGTTTTTGCAGGCATAAATTCTTATAGTCCAGAATAACGCCAAGAGTAATGTAAGGTAGGGAAACAGGCCAGGTGTGGCGGCTCATGCCGGTAATCGCAGCACATTAAGAGGCCAAGGTGGGTGGATTGCTTGAACCAGGACTTAGAGACCAGCCTAGGCAACATGGCAAAAGCCCACTCTACAAAAATACAAAAAGTAGGCCAGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAATATCAGCCTGTCCAACCTGGTAAAACCCCATCTCTACTAAAACATACAACATTTAGCTGGGCATGGTGGCGCACACCTGTAATCCCAGCTACTCCAGAGGCTGAGGCAGAAGAATCGCTTGAACTGGGGAGATGGAGATTGCAGTGAGCTGAGATTGCACCACCGAACTCCAGCCTGGGTGATGGAGAGAGAGTGCCGCAAAAAAAAAAAAAAAAAAAAAAAGCCAGGCGTGGTGGGGGGTACCGGCAGGCCCAGTACTTGGGAGGCTGAGGTAGGAGGATCACCTGAGCCCTGGGAGGTCAAGGCTGCAGTGAGCTGTGATACTGCACTCCAGCCTAGGTGACTGGGTGAGACCTTGTCTAAAAGAAAATAAAATAGGGGAAATAGATGCCCAAGGTCTGACAGGGGAGATCTCCCACCCCACTATGGAGGTCAGGGGTTAGCTTGGAAAAATGCATAGGAACTCGGCTGGGCAGGGTGGCTCATTCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTAGATCACTTGAGGTAGAAACCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTCGTCTGTACTAAAAATATGAAAATTAGCCTGGTGTGATGGTGCGCCTTTAATACCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTCAACCCCAGAGGCAGAGATTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCTTGGGTGACAGAGCGAACTCCCACCGTCTCAAAAACAAAGAAAAAAAAAAGTTGGGGGGAATAGATGCCCAGGGTCTGACAGTGCAGATCTCCCCGACCACCCCATGCACGTCAGGGGTTACCTTGGAAAAATGGGACCCGAGTCTCTCCCCAGCCCCCAATCCAGGCCTCACCCTTCGTGTGCCCACGCATGGAAGAGTCCTGAGCCTTGCTGGGTTGAGGCGGTTGGTCATTGTAGAGCAGGAAGGCGAGC
Task1_train_26571
Given a variant located on Chromosome 19 and affecting DNASE2 (deoxyribonuclease 2, lysosomal), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; Autoinflammatory-pancytopenia syndrome due to DNASE2 deficiency
TGGTCAAGGAGCAGGACACCTGGACCAAAAGAAGGCATTAGGGGAGGTCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGACACACAGATCACCTGAGGTCAGGAGTTAGAAATCAGCCTGGCCAACATGGCGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGAGCGTGGTGGTGGACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCCACCACTGCACTCCAGCCTGGGCCACAGAGCAAAATTTCATCTCAAACATAAGTAAGTAAGTAAGTAAATAAATAAATAAATAAATAAATAAATAAAAATTTAAAAAAAGAAGGCAGGCCCCACGCAGTGTAATCCCAGCACTTTGGGAAGCCGAGGAGGGCGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGGCCAACATGGAGAAACCTCATCACTACTAAAAATACAACATTAGCCGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGATGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCATTGCACTCCAGCCTGGGTAGCAAGAGCAAAACTCCTTCTCAAAAAAAAAAAAAAAAAAAAGGCAATTAGAGGGTATTGCTCCAGGCCTCCCAGCAAGCTCATCTGCAATCAGGAACACCCTCAGTTTGCAGCGGGGCTTAGAGAGGGTGCCAGCAGTGTTAGAACCACAGCTGAGCTCAGTTTTTGCAGGCATAAATTCTTATAGTCCAGAATAACGCCAAGAGTAATGTAAGGTAGGGAAACAGGCCAGGTGTGGCGGCTCATGCCGGTAATCGCAGCACATTAAGAGGCCAAGGTGGGTGGATTGCTTGAACCAGGACTTAGAGACCAGCCTAGGCAACATGGCAAAAGCCCACTCTACAAAAATACAAAAAGTAGGCCAGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAATATCAGCCTGTCCAACCTGGTAAAACCCCATCTCTACTAAAACATACAACATTTAGCTGGGCATGGTGGCGCACACCTGTAATCCCAGCTACTCCAGAGGCTGAGGCAGAAGAATCGCTTGAACTGGGGAGATGGAGATTGCAGTGAGCTGAGATTGCACCACCGAACTCCAGCCTGGGTGATGGAGAGAGAGTGCCGCAAAAAAAAAAAAAAAAAAAAAAAGCCAGGCGTGGTGGGGGGTACCGGCAGGCCCAGTACTTGGGAGGCTGAGGTAGGAGGATCACCTGAGCCCTGGGAGGTCAAGGCTGCAGTGAGCTGTGATACTGCACTCCAGCCTAGGTGACTGGGTGAGACCTTGTCTAAAAGAAAATAAAATAGGGGAAATAGATGCCCAAGGTCTGACAGGGGAGATCTCCCACCCCACTATGGAGGTCAGGGGTTAGCTTGGAAAAATGCATAGGAACTCGGCTGGGCAGGGTGGCTCATTCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTAGATCACTTGAGGTAGAAACCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTCGTCTGTACTAAAAATATGAAAATTAGCCTGGTGTGATGGTGCGCCTTTAATACCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTCAACCCCAGAGGCAGAGATTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCTTGGGTGACAGAGCGAACTCCCACCGTCTCAAAAACAAAGAAAAAAAAAAGTTGGGGGGAATAGATGCCCAGGGTCTGACAGTGCAGATCTCCCCGACCACCCCATGCACGTCAGGGGTTACCTTGGAAAAATGGGACCCGAGTCTCTCCCCAGCCCCCAATCCAGGCCTCACCCTTCGTGTGCCCACGCATGGAAGAGTCCTGAGCCTTGCTGGGTTGAGGCGGTTGGTCATTGTAGAGCAGGAAGGCGAGCTGCGGGCGGATAAACGGAGGCAACGTGAAATTCCTCCCAGGCAGGGCAGCCCTAGAGTTTCGCCCCTAGTTGGCCCGGGGCCCCCTTCACCTGGCTGGTGTTGCTCCGGTACAGCGGCTGCAGGCTTCGGCCCACGGCCCCCTCCGGGCTGTTGATGAGTGCCCTGCCGTCCCGCCAGCCTCCGGAGCTCTCGTCCAGATACTTGTACTGCAGCCCTCTCTGCGCCGCCTCCCCGGACCCTCTAAGAGCTGGCAGCTTGTAGACCACGAACCTGGAGGTCGGAGAATGCACAGAAATAGGAGAGAGGGAAGAGAAGGCACCCCAGGGTTCCCCGAGGAGGTAGCCATCCCGGTTGAGTGACCGCAGCCGGACCCCGGGGCGATGGTAGGCCCCCCGCTGCGCACTCACCAGTCTACAGGCTGCCCGGAGTCCCCGTAGCAGGTCAGGGCCCCGGCGGGGACGCACAGCAGCGCTGCCAGCAGCAGCGGGATCATAGCTGCTATGGGGCTGAGATCCAGGAATCTGTGTCGGGACTGCGGGGCGCTGGGTTACATCAGAGGCCAGGACTGGCACCTGGCGCCTTTCACTTCCCTAAACTTGCCTGGGAACCGGGGCGGGGACATCACGAGGGTACAGACTCCTCCCCCGAGACGCGATGCTGCGTTTTGGAGAGGCAAAAGGCAACGCTGAGTCTGCCCAGACCACGCCCACGACGGGCCCGGCGCTCCAGCGTCTCCTGGAGCCTGGCCACCGTTCCTTTTCGTGGTAGCTAATCCCAGCCCACGCTCTTCTGTCTGACCCAACTCCCGCCCGGGTTTCTGGATCAGGCACAAGTTTGTATTTTATTTTTTATTCCAGCCCTACAACCTGGGTCCAACTCTTGGGACCTTTGTTCTTCCTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTTTCACTCTTGTCGCCCAGGCTGGAGTGCAATGGCACGATCTCGGTTCACTGCAACCTCCGCCTTCCTGATTAAAGCGATTATCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCCCGACACCACGCCCGGCTAATTTTTGTAGTTTTAGTAGAGACGGGGTTTTTCCATGTTGACTAGGCTGGTCTCGAACTCCTGACCTCGTGATCCACCAGCCTCGGCCCCCGAAAGTGCCAAGATTGCAGAAGTGAGCCACTGCGCCCCTTAAGAAGCATTTGTGTTCCAGTGTATCTTCCCCTTTTTCTTTCTTTTTTTTTTTCCTTCCTTTTTTTTTTTTTTTTTTCCCGGACAATATCTCGCTCTGTTGCCCAGGCCGGAGTGCAGTGGCGCAATCTTGGCTCACTGCAACCTCTGCCTCCCCAGCTCAAGTGATCCTCTCACCTCAGCCTCCCGAGTAGCTGGGATCACGGGCACATGCCACTATGCCCAGCTAATTTTTGTAGTTTTTTTTTTGAAACACGGTTTCACCATGTGGCTCAGGCTGAACTCCTGAGCTCAAGGGATCCACCTGTCTTGCCTCCCAAAGTGCTGGGATTACAGGCATGTAATCCACGCCACCCAGACTCTCCTTTTTCATTCTGCACGTTTTCTCCAGGATCCCCTGAGCTAGCAAAGAGGTGACTGTATGTTTGTTTTTTGTCGTTTTGAGACAGGATAATGGTTTCTCACCCAGGCTAGAATGCAGTGACTCCATCACAGTTCACTGCAGCCTCAACCTACTGGGCTCAAGAGATCTTCCCAGGTAGCTGGTACTACAGGCCTGTGCCACCACACCCAGATAATTGTTCATTGCAGAGATGAGGGTCTCACTATGTTGCCCAGGCTGCTCTGGAACTCCGGGGTTCAAGTGATTCTCCCACCTCAGCCTCAAAGGATCATGGCAGGGCAAAGGGCTATGGGAATCTGAGTACTGGCTTGAAACTGCCTTTGCAAAAATTATGACAGAAAATTATGTCAGTGAAAGAGCTCTGACCTAACCAACTCCATCTTGCCTTTAATCTCCAAACTGCCCTTGCTTGGTCAT
TGGTCAAGGAGCAGGACACCTGGACCAAAAGAAGGCATTAGGGGAGGTCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGACACACAGATCACCTGAGGTCAGGAGTTAGAAATCAGCCTGGCCAACATGGCGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGAGCGTGGTGGTGGACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCCACCACTGCACTCCAGCCTGGGCCACAGAGCAAAATTTCATCTCAAACATAAGTAAGTAAGTAAGTAAATAAATAAATAAATAAATAAATAAATAAAAATTTAAAAAAAGAAGGCAGGCCCCACGCAGTGTAATCCCAGCACTTTGGGAAGCCGAGGAGGGCGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGGCCAACATGGAGAAACCTCATCACTACTAAAAATACAACATTAGCCGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGATGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCATTGCACTCCAGCCTGGGTAGCAAGAGCAAAACTCCTTCTCAAAAAAAAAAAAAAAAAAAAGGCAATTAGAGGGTATTGCTCCAGGCCTCCCAGCAAGCTCATCTGCAATCAGGAACACCCTCAGTTTGCAGCGGGGCTTAGAGAGGGTGCCAGCAGTGTTAGAACCACAGCTGAGCTCAGTTTTTGCAGGCATAAATTCTTATAGTCCAGAATAACGCCAAGAGTAATGTAAGGTAGGGAAACAGGCCAGGTGTGGCGGCTCATGCCGGTAATCGCAGCACATTAAGAGGCCAAGGTGGGTGGATTGCTTGAACCAGGACTTAGAGACCAGCCTAGGCAACATGGCAAAAGCCCACTCTACAAAAATACAAAAAGTAGGCCAGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAATATCAGCCTGTCCAACCTGGTAAAACCCCATCTCTACTAAAACATACAACATTTAGCTGGGCATGGTGGCGCACACCTGTAATCCCAGCTACTCCAGAGGCTGAGGCAGAAGAATCGCTTGAACTGGGGAGATGGAGATTGCAGTGAGCTGAGATTGCACCACCGAACTCCAGCCTGGGTGATGGAGAGAGAGTGCCGCAAAAAAAAAAAAAAAAAAAAAAAGCCAGGCGTGGTGGGGGGTACCGGCAGGCCCAGTACTTGGGAGGCTGAGGTAGGAGGATCACCTGAGCCCTGGGAGGTCAAGGCTGCAGTGAGCTGTGATACTGCACTCCAGCCTAGGTGACTGGGTGAGACCTTGTCTAAAAGAAAATAAAATAGGGGAAATAGATGCCCAAGGTCTGACAGGGGAGATCTCCCACCCCACTATGGAGGTCAGGGGTTAGCTTGGAAAAATGCATAGGAACTCGGCTGGGCAGGGTGGCTCATTCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTAGATCACTTGAGGTAGAAACCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTCGTCTGTACTAAAAATATGAAAATTAGCCTGGTGTGATGGTGCGCCTTTAATACCAGCTACTTGGGAGGCTGAGACAGGAGAATTGCTTCAACCCCAGAGGCAGAGATTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCTTGGGTGACAGAGCGAACTCCCACCGTCTCAAAAACAAAGAAAAAAAAAAGTTGGGGGGAATAGATGCCCAGGGTCTGACAGTGCAGATCTCCCCGACCACCCCATGCACGTCAGGGGTTACCTTGGAAAAATGGGACCCGAGTCTCTCCCCAGCCCCCAATCCAGGCCTCACCCTTCGTGTGCCCACGCATGGAAGAGTCCTGAGCCTTGCTGGGTTGAGGCGGTTGGTCATTGCAGAGCAGGAAGGCGAGCTGCGGGCGGATAAACGGAGGCAACGTGAAATTCCTCCCAGGCAGGGCAGCCCTAGAGTTTCGCCCCTAGTTGGCCCGGGGCCCCCTTCACCTGGCTGGTGTTGCTCCGGTACAGCGGCTGCAGGCTTCGGCCCACGGCCCCCTCCGGGCTGTTGATGAGTGCCCTGCCGTCCCGCCAGCCTCCGGAGCTCTCGTCCAGATACTTGTACTGCAGCCCTCTCTGCGCCGCCTCCCCGGACCCTCTAAGAGCTGGCAGCTTGTAGACCACGAACCTGGAGGTCGGAGAATGCACAGAAATAGGAGAGAGGGAAGAGAAGGCACCCCAGGGTTCCCCGAGGAGGTAGCCATCCCGGTTGAGTGACCGCAGCCGGACCCCGGGGCGATGGTAGGCCCCCCGCTGCGCACTCACCAGTCTACAGGCTGCCCGGAGTCCCCGTAGCAGGTCAGGGCCCCGGCGGGGACGCACAGCAGCGCTGCCAGCAGCAGCGGGATCATAGCTGCTATGGGGCTGAGATCCAGGAATCTGTGTCGGGACTGCGGGGCGCTGGGTTACATCAGAGGCCAGGACTGGCACCTGGCGCCTTTCACTTCCCTAAACTTGCCTGGGAACCGGGGCGGGGACATCACGAGGGTACAGACTCCTCCCCCGAGACGCGATGCTGCGTTTTGGAGAGGCAAAAGGCAACGCTGAGTCTGCCCAGACCACGCCCACGACGGGCCCGGCGCTCCAGCGTCTCCTGGAGCCTGGCCACCGTTCCTTTTCGTGGTAGCTAATCCCAGCCCACGCTCTTCTGTCTGACCCAACTCCCGCCCGGGTTTCTGGATCAGGCACAAGTTTGTATTTTATTTTTTATTCCAGCCCTACAACCTGGGTCCAACTCTTGGGACCTTTGTTCTTCCTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTTTCACTCTTGTCGCCCAGGCTGGAGTGCAATGGCACGATCTCGGTTCACTGCAACCTCCGCCTTCCTGATTAAAGCGATTATCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCCCGACACCACGCCCGGCTAATTTTTGTAGTTTTAGTAGAGACGGGGTTTTTCCATGTTGACTAGGCTGGTCTCGAACTCCTGACCTCGTGATCCACCAGCCTCGGCCCCCGAAAGTGCCAAGATTGCAGAAGTGAGCCACTGCGCCCCTTAAGAAGCATTTGTGTTCCAGTGTATCTTCCCCTTTTTCTTTCTTTTTTTTTTTCCTTCCTTTTTTTTTTTTTTTTTTCCCGGACAATATCTCGCTCTGTTGCCCAGGCCGGAGTGCAGTGGCGCAATCTTGGCTCACTGCAACCTCTGCCTCCCCAGCTCAAGTGATCCTCTCACCTCAGCCTCCCGAGTAGCTGGGATCACGGGCACATGCCACTATGCCCAGCTAATTTTTGTAGTTTTTTTTTTGAAACACGGTTTCACCATGTGGCTCAGGCTGAACTCCTGAGCTCAAGGGATCCACCTGTCTTGCCTCCCAAAGTGCTGGGATTACAGGCATGTAATCCACGCCACCCAGACTCTCCTTTTTCATTCTGCACGTTTTCTCCAGGATCCCCTGAGCTAGCAAAGAGGTGACTGTATGTTTGTTTTTTGTCGTTTTGAGACAGGATAATGGTTTCTCACCCAGGCTAGAATGCAGTGACTCCATCACAGTTCACTGCAGCCTCAACCTACTGGGCTCAAGAGATCTTCCCAGGTAGCTGGTACTACAGGCCTGTGCCACCACACCCAGATAATTGTTCATTGCAGAGATGAGGGTCTCACTATGTTGCCCAGGCTGCTCTGGAACTCCGGGGTTCAAGTGATTCTCCCACCTCAGCCTCAAAGGATCATGGCAGGGCAAAGGGCTATGGGAATCTGAGTACTGGCTTGAAACTGCCTTTGCAAAAATTATGACAGAAAATTATGTCAGTGAAAGAGCTCTGACCTAACCAACTCCATCTTGCCTTTAATCTCCAAACTGCCCTTGCTTGGTCAT
Task1_train_26572
This mutation occurs in KLF1 (KLF transcription factor 1) on Chromosome 19. Does this change lead to a known medical condition, or is it benign?
Pathogenic; BLOOD GROUP--LUTHERAN INHIBITOR
TCTGACCTAACCAACTCCATCTTGCCTTTAATCTCCAAACTGCCCTTGCTTGGTCATTCCTGGAGTGGGGTCAAGCTAACTTTTTTTTTTTTTTTGACACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTA
TCTGACCTAACCAACTCCATCTTGCCTTTAATCTCCAAACTGCCCTTGCTTGGTCATTCCTGGAGTGGGGTCAAGCTAACTTTTTTTTTTTTTTTGACACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATTTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTA
Task1_train_26573
The gene KLF1, LOC117125591 (KLF transcription factor 1| CRISPRi-FlowFISH-validated PRDX2 and RAD23A regulatory element) is located on Chromosome 19, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Congenital dyserythropoietic anemia type 4
CTGGAGTGGGGTCAAGCTAACTTTTTTTTTTTTTTTGACACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCC
CTGGAGTGGGGTCAAGCTAACTTTTTTTTTTTTTTTGACACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGAGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCC
Task1_train_26574
Gene KLF1, LOC117125591 (KLF transcription factor 1| CRISPRi-FlowFISH-validated PRDX2 and RAD23A regulatory element) on Chromosome 19 is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 6
CTGGAGTGGGGTCAAGCTAACTTTTTTTTTTTTTTTGACACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCC
CTGGAGTGGGGTCAAGCTAACTTTTTTTTTTTTTTTGACACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGAGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCC
Task1_train_26575
A mutation in KLF1, LOC117125591 (KLF transcription factor 1| CRISPRi-FlowFISH-validated PRDX2 and RAD23A regulatory element), located on Chromosome 19, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; BLOOD GROUP--LUTHERAN INHIBITOR
CTGGAGTGGGGTCAAGCTAACTTTTTTTTTTTTTTTGACACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCC
CTGGAGTGGGGTCAAGCTAACTTTTTTTTTTTTTTTGACACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGAGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCC
Task1_train_26576
Given this context: Chromosome 19, gene KLF1, LOC117125591 (KLF transcription factor 1| CRISPRi-FlowFISH-validated PRDX2 and RAD23A regulatory element) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; BLOOD GROUP--LUTHERAN INHIBITOR
TGACACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCCTGGATTCCAGCCAGCCCACCTAGACCCCACCTTCT
TGACACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCCGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCCTGGATTCCAGCCAGCCCACCTAGACCCCACCTTCT
Task1_train_26577
Located on Chromosome 19, this mutation impacts KLF1, LOC117125591 (KLF transcription factor 1| CRISPRi-FlowFISH-validated PRDX2 and RAD23A regulatory element). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; BLOOD GROUP--LUTHERAN INHIBITOR
ACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCCTGGATTCCAGCCAGCCCACCTAGACCCCACCTTCTAGGC
ACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTTGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCCTGGATTCCAGCCAGCCCACCTAGACCCCACCTTCTAGGC
Task1_train_26578
A variant affecting Chromosome 19, within the gene KLF1, LOC117125591 (KLF transcription factor 1| CRISPRi-FlowFISH-validated PRDX2 and RAD23A regulatory element), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Congenital dyserythropoietic anemia type 4
ACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCCTGGATTCCAGCCAGCCCACCTAGACCCCACCTTCTAGGC
ACGTTGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGTGTGATCTCAGCTCACTGCAACATCCGCCTCCTAGGTTCAAGCAATCCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGCGCCACATGCCCAGCTAATTTTTGTATTTTTGGTAGAGACTGGGTTTCACCATTTTTGGTAGAGATGGGGTTTCACCTTGGGGCTCAGGCTGGTGTCGAACTCCTGGGCTCAAGTGATCTGCCCGCCTCAGCCTGCCAAATTGCTGGGATTAAAGAGGGAGCCACCATGCCTGGCCCCAAGCTAATTTTGGGAGGAATTTAGTTTATAGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTTGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCCTGGATTCCAGCCAGCCCACCTAGACCCCACCTTCTAGGC
Task1_train_26579
A mutation in KLF1, LOC117125591 (KLF transcription factor 1| CRISPRi-FlowFISH-validated PRDX2 and RAD23A regulatory element), located on Chromosome 19, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; BLOOD GROUP--LUTHERAN INHIBITOR
AGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCCTGGATTCCAGCCAGCCCACCTAGACCCCACCTTCTAGGCCCCACCTTGAGGAAGTCATCCTGTGTGTCCGGGAAGGGGCCCAGGGCGGTCAGTGTGCTGATGGAGGGCAAGGCGGTCTCGGCTGTGGCCATGGCTGGCTGGTGCCCACCCTGGGCCTCAAGCCTCCTCTTCCTCGGCTGCCTCGTGAACTCTGAGGCTGTGATAGCCCCTTCGAGGGCTCCTCTCTGTCCTTAGCTGATTGGCTGCAGCCTCTGATAAGGCAAAGCAAGGCAAGGCGGCGGGGGGGCACTGTTTCTGGGGCACAAACTTCACGTTGGCCTGTCTGGGGCTGGGGTTAAAGACTAACCCTGTGTCCAAAGCCAAGTCAAATATC
AGCTTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATACGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCCTGGATTCCAGCCAGCCCACCTAGACCCCACCTTCTAGGCCCCACCTTGAGGAAGTCATCCTGTGTGTCCGGGAAGGGGCCCAGGGCGGTCAGTGTGCTGATGGAGGGCAAGGCGGTCTCGGCTGTGGCCATGGCTGGCTGGTGCCCACCCTGGGCCTCAAGCCTCCTCTTCCTCGGCTGCCTCGTGAACTCTGAGGCTGTGATAGCCCCTTCGAGGGCTCCTCTCTGTCCTTAGCTGATTGGCTGCAGCCTCTGATAAGGCAAAGCAAGGCAAGGCGGCGGGGGGGCACTGTTTCTGGGGCACAAACTTCACGTTGGCCTGTCTGGGGCTGGGGTTAAAGACTAACCCTGTGTCCAAAGCCAAGTCAAATATC
Task1_train_26580
This alteration in LOC117125591, KLF1 (CRISPRi-FlowFISH-validated PRDX2 and RAD23A regulatory element| KLF transcription factor 1) on Chromosome 19 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; not provided
TTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGCCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCCTGGATTCCAGCCAGCCCACCTAGACCCCACCTTCTAGGCCCCACCTTGAGGAAGTCATCCTGTGTGTCCGGGAAGGGGCCCAGGGCGGTCAGTGTGCTGATGGAGGGCAAGGCGGTCTCGGCTGTGGCCATGGCTGGCTGGTGCCCACCCTGGGCCTCAAGCCTCCTCTTCCTCGGCTGCCTCGTGAACTCTGAGGCTGTGATAGCCCCTTCGAGGGCTCCTCTCTGTCCTTAGCTGATTGGCTGCAGCCTCTGATAAGGCAAAGCAAGGCAAGGCGGCGGGGGGGCACTGTTTCTGGGGCACAAACTTCACGTTGGCCTGTCTGGGGCTGGGGTTAAAGACTAACCCTGTGTCCAAAGCCAAGTCAAATATCAAG
TTAAATGATAATAGCCCTTCCCCAAACTAAACTGCCTTTGTAGAAATAATGAAAGGGCACTAGGTTAGGAGGATGAGAGGAGCCTGAATTCTGCTAAACTGTAGGTGTAGTAGTTAAATTATGACCAGCCATTTTTCCGGCCGGGTGCGGTGCCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGCTGGCAGATTACCTGAGGTCAGGATTTCGAAACCAGCCTGGCCAGCATTTCGAAACCCCATCTCTTCTAAAAATACAAAAATTAGCCCGGCATGGTGGCATGTGCCTGTAATCCTAGCTACCTGGTAGGCTGACACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGAACAACTGCACTCCAGCCTGGGCAAGAGCAAGACTCCATCTCAAAAACAAAAACAAAGATGGCCAGCCATTATTCTGGAGGTCACAAGGTTTGCAACTTCCCCAGTTATTTCTGCAAATAACATGACTATTGCAAAACCTAACGCTGGCCTTTTTAGATGTCTTTTTAGGCTTTTTGCATATCTGACAACTGGATGACTCCACCCAGACTAGCGACTCTATGGTCCCCACCCAGAAGCTGACTCAGCAACTGTTTTCCACAGCTCCAGGATTGCAGCAAGGCACCCATTCCCTAGCCCTCCTGCCCACCAAACTGTTCTTGAATAACCCTAGCCTCTGAATTTTCAGGGAGGCTGATTCAAGTAATAAAACTCCCATCTCCCATTTAGCTGGATGTATGTGGATTAAACTCTCTCTATTGCAATCCCTCTGTCTCGATAAATTGGCTCTATCTGGACAGTGGGCAAGATGAACCCCCTGGGCAGTCATAGGCTGTGAACTCTTAAATCCAGGGAGATGTTTGCTGTCAATGTCCGCAGGGTTCAAGGCAGAAGACAAGGACAGTGTAGCCTGAACTGGGTGGGAAAAGAGAGGACAGCAAGGCCTCCAGTGCCCAAGGGGGCTTGTTGGAGTTGAGGGGTGTCACTGTAGTTTAGGAGATGAGGGTGTGTAAGGCCCTCTAATATGACCTCTAGGTTTACAGCCTCCTGCCATCTTCCAGCCTCCAAAACCCAAAAATTCAGGCCAACGCTGAAGCTTTATCTGGGAGGGGCATTTTTATAGGACCCATAACCATTGACAGTTAATATCAGCCACAATAAGGGACCTTCAGGAGCCGCTTTCTAGACCCAGGGTCTCTGGGAAGCCTCATCCCACACCCTCTCCTGCTGTCCAGGGCCATCTGGGAGCTGGTCTGAGTGTCCACTGAGTCCGTTTATTTGGCGGTCTGTCTCACTGGGTTTGCACGACAGTTTGGACATCTCTGTGTGGCTCCCTGTGGCTGAAGGCTTGTCGGATTTTCCGTAAGAGGCTCCCCCAGGGCTGTCTATGGGTCCGTGTTTGATATTTGGGTGGATCTTTGGGAACGCGAGTCCAGGAGAGGGTCCATTCGTGGGAAAACCACCCAGCATTGTGTCACGCGCGTCCGTGTGAAGAGACCACCAAACAGGCTTCTTGTCCCATCCCCAGTCACTAGGAGAGTCCAAGTGCCAGGGCAGGGCTCAAAGGTGGCGCTTCATGTGCAAGGCCAGGTGGTCAGAGCGCGAAAAAGCACGTGGGCAGAGCTGGCAGCGGAAGGGGCGCTGCCCCGTGTGTTTCCGGTAGTGGCGGGTCAGCTCGTCCGAGCGCGCGAATCTCCAGCCGCAGCCTTCCCACGTGCAGGCGTATGGCTTCTCCCCTAGGGGACAAGGAAGCCATAAGCGCCACTGTCTGCCCAGTCATGTCCCCGGGTCCCCTGCATCTGGCCACACCCCTTTACTCAGCCTGGGCTGGGACTAGGATGAACAAAGTGAGGCCCCTAGGGCACAAAATTTAAGGAGGCACTCACTCTCAGAGGCCAGCCAAGTCCAAGTCCCGCCCTCTGCAACCCTTCTTCCCCTGTAACTACAGCGGGCGCCGCGCCCTTTCTCATGTCCGGGGCCCCGCCCCCTCACCTGTGTGCGTGCGCAGATGCGGCTTCAGGTGGGAGCTCTTGGTGTAGCTCTTGCCGCAACCCGGGTGCGCGCACGTGTGCGCTGCCTGCCTCTTGCGCGCCCACGAACGTCGGCCTCGCTTGGATGGCGCGGTCTCGGCTATCACACCTGGATCCTCTGCAGTCCCCCCGAGTCCAGTGCCCACCGTCCCGGGTCCCAAACAACTCAGGAAGGAGGGGGACGTGGCGGGACCGGGCGCGGGTCCCTGGAGCCCGCGGAAGAGCTGGAAGTGCCCTTGGTACTGAGGCGCCGGGTACATCGCGGGGTACCCGGACAGTAGCCCGTAGGGGGCGCCCGACGCCGCAGGCACTGAAAGCCCGGTCCGCGGGAAGTAGCCACCCGAGGAGCCGGCGCCGGGCCCCGGGTACACCGGTTGCAGCGCCAGCGCCTTGGGCTCGGGGGCCGGGGCTGGAGCCAGGGCTGGGCCCACGAAGGCGTCGGGAGCCCGGGCTCGCAGGGCAGGGCGCACCCAACCCGAGTGATCCTCCGAACCCAAAAGCCCAGCCACCAGCCCCGGGCCGCCAGCATATGCGCCCAGAGTCTCGGGCGGCGGCGGATATTGCGCCCCGGAGGCCTCGCTGGGCGCCAGAGCGCAGGTCTGGGGCGCGCCACCGGGCTCCGGGCCCGAGAAGTTGGTGAGGAGGAGATCCAGGTCCCAGGTGGCGTCCGCGCCCCTCTCATCGTCCTCTTCCTCCCCGGGCTGGTCCTCAGACTTCACGTGGAGGGGCGGCTCCGTGGGGTCAGGAGGACCCGGGCCCATGTCCTGCGCCTCTTCGGAGCGCCACCACTGCGGGAGGGAGCAGGCAGCTCGAGGTTCGGTGGACACTGGGGTGCCCTGCCCAGGGACATCGCGGGCTGGACACTCTGACGCAGAGGCTTTGGAAAGGGGTCTTGTTTGCCTGTCTGTCTGTCCCACTTCCCCAACACTGCCCCTCTAACCGCCCCTCTCCCCGCTCCCCCCCCAGCTCCAGGGACAGAAACCGATCAGGTCTGGCTGGAGACAGGAGATAAGACTTCCACTATCTGGAACCACACTCGGGGATGGGGGAAGGGGTAGCAGAGCTGCTGGAGATGGAAAACTGGCAGGGGACGGGGGAGAGGATGCCAGCCTTGACTTAGTTTTCCCCCAGAACATCCCTCTCCTTCCCTGTCTCCCAAAACAAGATTAATTCCGAAATTTTGGATGTCCCCCAGACACACTCATCATTTCCCGCTGATATCTGGAAGATTGTCTGTGAGCCTAGATCTCGTTCCTTTTTTTTTTTTTTTTTCTTGAGATAGGGTCTTACTCTTTTGCCCAGGCTGGAGTGCAGTGGTGCAGCTCACTGTATCCTTAATCTCCTGGGCTCTAATGATCCTCCTGCATCAGCCTACGGAGTACCTGGGACTACAGGCACACGCCCCCATGCCTGGCCTAATGTTTTTGGTATTTTTTGTAGAGATAGGGTTTCACCATGTTGCCCAGGCTACCTTCGTTTTCTATTACCGAAATAGATCACACTTAGAACCTCAAACCCCTAGACCACCCTCCTCACCCCCTGCCAGACTAAGCTGAGATCTCCTCTCCTGGACTGAGCGTACCTCAGTCCTGGTTAAGTCTCTTGATTTCAGGTCAAGATGCAGGTCTGGACCCCAAGATCTGTGACTGTGGCCCTGGATTCCAGCCAGCCCACCTAGACCCCACCTTCTAGGCCCCACCTTGAGGAAGTCATCCTGTGTGTCCGGGAAGGGGCCCAGGGCGGTCAGTGTGCTGATGGAGGGCAAGGCGGTCTCGGCTGTGGCCATGGCTGGCTGGTGCCCACCCTGGGCCTCAAGCCTCCTCTTCCTCGGCTGCCTCGTGAACTCTGAGGCTGTGATAGCCCCTTCGAGGGCTCCTCTCTGTCCTTAGCTGATTGGCTGCAGCCTCTGATAAGGCAAAGCAAGGCAAGGCGGCGGGGGGGCACTGTTTCTGGGGCACAAACTTCACGTTGGCCTGTCTGGGGCTGGGGTTAAAGACTAACCCTGTGTCCAAAGCCAAGTCAAATATCAAG
Task1_train_26581
This variant affects gene GCDH, LOC117125594 (glutaryl-CoA dehydrogenase| H3K27ac-H3K4me1 hESC enhancers GRCh37_chr19:13001481-13002118 and GRCh37_chr19:13002119-13002756) located on Chromosome 19. Evaluate its biological effect and specify any disease association.
Pathogenic; Glutaric aciduria, type 1
CCTCAGGTGACCCACCCTCCTTGGCCTCCCAAAGTGCTGGGATGACAGGCATGAGCCGCCCCAGCCAGTCAAAACCTACACTTTATACAGTCACACCACCGGTCACTTTTACAATATGTAAAGTAATTATTTAGTCACAGTTGCATAGCTACCAGTGCCCAACCGTAGGGGATGCACCCAGTTAAACACAGACAAACGCAAGGACATGGCATCACAGGTCCTGAGAATCAAGACACACACATTTCTCAACAGATACACAATCAGAATGGGTGCACCACAAATGCACTACACAAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAA
CCTCAGGTGACCCACCCTCCTTGGCCTCCCAAAGTGCTGGGATGACAGGCATGAGCCGCCCCAGCCAGTCAAAACCTACACTTTATACAGTCACACCACCGGTCACTTTTACAATATGTAAAGTAATTATTTAGTCACAGTTGCATAGCTACCAGTGCCCAACCGTAGGGGATGCACCCAGTTAAACACAGACAAACGCAAGGACATGGCATCACAGGTCCTGAGAATCAAGACACACACATTTCTCAACAGATACACAATCAGAATGGGTGCACCACAAATGCACTACACAAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGCCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAA
Task1_train_26582
A mutation in GCDH (glutaryl-CoA dehydrogenase), located on Chromosome 19, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Glutaric aciduria, type 1
TTTACAATATGTAAAGTAATTATTTAGTCACAGTTGCATAGCTACCAGTGCCCAACCGTAGGGGATGCACCCAGTTAAACACAGACAAACGCAAGGACATGGCATCACAGGTCCTGAGAATCAAGACACACACATTTCTCAACAGATACACAATCAGAATGGGTGCACCACAAATGCACTACACAAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGC
TTTACAATATGTAAAGTAATTATTTAGTCACAGTTGCATAGCTACCAGTGCCCAACCGTAGGGGATGCACCCAGTTAAACACAGACAAACGCAAGGACATGGCATCACAGGTCCTGAGAATCAAGACACACACATTTCTCAACAGATACACAATCAGAATGGGTGCACCACAAATGCACTACACAAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGGCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGC
Task1_train_26583
This sequence change occurs on Chromosome 19, altering GCDH (glutaryl-CoA dehydrogenase). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; not specified
TTTACAATATGTAAAGTAATTATTTAGTCACAGTTGCATAGCTACCAGTGCCCAACCGTAGGGGATGCACCCAGTTAAACACAGACAAACGCAAGGACATGGCATCACAGGTCCTGAGAATCAAGACACACACATTTCTCAACAGATACACAATCAGAATGGGTGCACCACAAATGCACTACACAAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGC
TTTACAATATGTAAAGTAATTATTTAGTCACAGTTGCATAGCTACCAGTGCCCAACCGTAGGGGATGCACCCAGTTAAACACAGACAAACGCAAGGACATGGCATCACAGGTCCTGAGAATCAAGACACACACATTTCTCAACAGATACACAATCAGAATGGGTGCACCACAAATGCACTACACAAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGGCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGC
Task1_train_26584
A sequence alteration has been identified in GCDH (glutaryl-CoA dehydrogenase) on Chromosome 19. Is it disease-inducing or harmless?
Pathogenic; Glutaric aciduria, type 1
AATATGTAAAGTAATTATTTAGTCACAGTTGCATAGCTACCAGTGCCCAACCGTAGGGGATGCACCCAGTTAAACACAGACAAACGCAAGGACATGGCATCACAGGTCCTGAGAATCAAGACACACACATTTCTCAACAGATACACAATCAGAATGGGTGCACCACAAATGCACTACACAAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGG
AATATGTAAAGTAATTATTTAGTCACAGTTGCATAGCTACCAGTGCCCAACCGTAGGGGATGCACCCAGTTAAACACAGACAAACGCAAGGACATGGCATCACAGGTCCTGAGAATCAAGACACACACATTTCTCAACAGATACACAATCAGAATGGGTGCACCACAAATGCACTACACAAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATTGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGG
Task1_train_26585
This variant affects the gene GCDH (glutaryl-CoA dehydrogenase) found on Chromosome 19. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Glutaric aciduria, type 1
TGGGTGCACCACAAATGCACTACACAAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCT
TGGGTGCACCACAAATGCACTACACAAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTGTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCT
Task1_train_26586
A variant affecting Chromosome 19, within the gene GCDH (glutaryl-CoA dehydrogenase), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Glutaric aciduria, type 1
AAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGA
AAAAAGACAAAACAGGCGGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTTGAGGCCAGCCTGGCCAACATGGTGAAACCCGTCTCTATTAAATATAAGAAAAAAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAATCCAGTAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCTACTGCACTCCAGCCTGGGCAACAGAGTGAGAATCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATGATGGCATGCTTCAGTGGTCCCAGCTACTTGGAGGCTGAGGTGGGAGGATCGCCCAGGAGGTGGAAGCTGCAGTGAGCTATGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAACGAGACCCTGTCTAAAAAGAAAAAACAAAAACAAAACAAAACAACCACATAGACTCACAGAATCACACAAGTTCACACACACACACACATACACAGACACAGACACACACACACACACACACACACACACACAGAGTCACAAGTATCTACATGTGCTTCCTGGGACAGACTGGCAGAAAGGTTTGCTAAGATCGCCCACTTGGAGCTCGTCTTCCCCACAACCAGCACCCAATTAGAGAACTCGAGTCTGGCCTCCTGGGTTCAGGAGGACGCCTAGTGCTCGCGCCAGAATTTCTTTGTTTAATTCTTGACTCCCTCCGCACACACCCCCTGCAACTGACCAACCAGGAGTGGGCCGAGCCCTTTCCTACGGCCAATAAGAGGAGAAACCCAGCTGGCCAATCGGTTTCCCGCACTCGTCTTCCGCCCCTACCCCGTCCGCTTCTTAAAGGGGCTAGCCTATCTCTGTCTGGGCCCCCCGATTTCCACAGGCAAGGCTACCTTAGCCCTTTTAAAAGGCAGAGCTGCGGAGGGGGCCGGATTCTAGGAGGAACCAATGAAAAGCCTCACTCGGCCTCCGCTCCTCCCACTTCTTGCTGAGGTCAAAGGCCTGCGTCAGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTAAGGAAGGTGCGGTAGCCCCAGCCGTGGGTGAGAGGAGCTCCGCTCTGACACCCCCGCTCCTGTAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGGTCAGTGTGGGGTCGGGAGTGTGGAGGGAAGGAGGGAGGAACTGGGGGTTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATAGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGA
Task1_train_26587
A genomic change on Chromosome 19 affects GCDH (glutaryl-CoA dehydrogenase). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Glutaric aciduria, type 1
TTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATG
TTTAGGGACTTTCCGGGGTGACTTTCCCGTTCTGTGCTTGCAGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTATGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATG
Task1_train_26588
Located on Chromosome 19, this mutation impacts GCDH (glutaryl-CoA dehydrogenase). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; not specified
GAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTA
GAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGCGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTA
Task1_train_26589
A genomic change on Chromosome 19 affects GCDH (glutaryl-CoA dehydrogenase). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Glutaric aciduria, type 1
GAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTA
GAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGCGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTA
Task1_train_26590
This alteration occurs within gene GCDH (glutaryl-CoA dehydrogenase) located on Chromosome 19. Is it associated with a disease or is it a benign variant?
Pathogenic; Glutaric aciduria, type 1
AAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAG
AAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCCGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAG
Task1_train_26591
A mutation found in GCDH (glutaryl-CoA dehydrogenase) on Chromosome 19 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Glutaric aciduria, type 1
GAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTT
GAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGATGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTT
Task1_train_26592
Given this context: Chromosome 19, gene GCDH (glutaryl-CoA dehydrogenase) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; not specified
GAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTT
GAGAACACAGAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGATGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTT
Task1_train_26593
A variant found in Chromosome 19 affects GCDH (glutaryl-CoA dehydrogenase). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Glutaric aciduria, type 1
GAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATAT
GAGCCAACTGGCTAAGTGTAAGGACCTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTTGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATAT
Task1_train_26594
This is a variant in GCDH (glutaryl-CoA dehydrogenase), located on Chromosome 19. Is this mutation a likely cause of disease or not?
Pathogenic; Glutaric aciduria, type 1
CTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTT
CTCTGGTCGCACCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCCGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTT
Task1_train_26595
This genomic variant is located on Chromosome 19, within the GCDH (glutaryl-CoA dehydrogenase) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Glutaric aciduria, type 1
CCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTTTTTGAGATGGA
CCGTGTGTCTGCTGCCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCATCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTTTTTGAGATGGA
Task1_train_26596
This sequence change occurs on Chromosome 19, altering GCDH (glutaryl-CoA dehydrogenase). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; Glutaric aciduria, type 1
CCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTTTTTGAGATGGAGTCTTGCTCTGTTG
CCCCTGTTCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATGTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTTTTTGAGATGGAGTCTTGCTCTGTTG
Task1_train_26597
Mutation context: Chromosome 19, Gene GCDH (glutaryl-CoA dehydrogenase). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Glutaric aciduria, type 1
TCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGC
TCAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCCATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGC
Task1_train_26598
Gene GCDH (glutaryl-CoA dehydrogenase) on Chromosome 19 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Glutaric aciduria, type 1
CAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCT
CAGCTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTGTGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCT
Task1_train_26599
This genomic variant is located on Chromosome 19, within the GCDH (glutaryl-CoA dehydrogenase) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Glutaric aciduria, type 1
CTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGTA
CTGTCTGTCTGCCGCAGGTGGACTCTGTCCCAGAATCCGAGAGCTGCCCGAGCGGGGTGGCAGGGTCGTGGCCAGGGTCAGAGGCACTAAGGCAGTGAGTGCGCTGTGCCTGCGGGGCCGGAGAAAAGTCACCTGATCAGTCTCGCTTGCAGCTCGCACTAGCCGGGGGGCGACATGGGTGTTGGGGGGTAGGGCTGATGAGGGTCCGAGAAGGGAGGGCACAGTGATCTTGCGGACTGGACCGAGGCGAATTCCCCTTCCCAGCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGGTGGGCGGGCTGGTGGGTGCCCTGAGACTGCTCCTCCGCCTGGAGCCATAGCCACCCCACCTCAAGGCCCCTCTGTCCTTGGGGCTGGGGCTTCCTGTGGCCTAGGCCTGGGCCTGAATTTGGGCACTGGTCCCTTTGCAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGTAGGAACAAGTATCTCTCCACACACTGCAGAACCCTCTGTATTCTGAAAGCCTCTTCCTCCTTCCCTCCCTCCCTTTCTTCCTTCCTTCTCTTTCTTTTCTTTTCCTTTTCTTTCCTTTCTTCTTCCCCCCCAACAGAGTCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAAATTCTGCCTCCCAGGCTCAAGCGATTCTCCTGCCTCCACCCCTCTAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCACCTCAGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCACGTTCAGCCTTCTTTTTGAGATGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAGTGATGCAATCTTGGCTCACTGCAGCCTCCACCTCCCGGGTTTAAGTGATTATCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGCGTCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCTGATTACAGGTGTGAGCCACCGTTGCCCGGCCCTTTTCTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTGTCACCCAGCCTGGATTACTGGATTACAGTGGTGCGATCCTGGCTCACTGCAGTTTCCTCCTCCTAGGTTCAAGCAATTCTGCCACCTCAGCCTTCTGAGTAGCTGGGATTACAGGGGTGCACCACCACGCCCAGCTAATTTTTGTATTTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAAACGTGAGCCACCGTGCCTGGCCCCTTTGTTTCTTTTTTTAGAGACAGGGTCTCACTGTGTTGCCCAGGCTGTTCTCAAGTGATCCTCTTGCCTTACTGAAAGCCCCCTTCTTTCCCTAAGCCACAATTTCCCAGTCTGTAAAGTGGGGCTGTTGTCCCACCCTCTGAAAGTGGCTGTGGAGATGAAATGAATAAACCTCAGCTAGGGCCAGCTTGGTGCCTGCCTCCTTGTGTGTCCTTATTCAGCCCTGTCTCTTGGGTCTTAGCTGGGCAGGGCCCTGTTCTCTATTGTCCTGCTTTCCCCTCCTACTACCACCAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGTCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGGTGAGTGGCTGCCCATGGGGCCTGGTGGAAGGAAGACAGTCTCTGAGGTCTGGAACTCAAGGGTGGGGCTGTCCCCTGAGCCTATTCTGTCCCTATCTCAAAGATAGCATAAGTGGCCACCTGGACCCCCGCCAGACCCTGGGCTTCACCTGGAGATCTGATCCCTGGCCAGCCTGACTGTCCCCCTCTGTGACCACCGTCATCTCCCTATGCTTTCTGTGTTCCCCAGTCCAGCCCAAAGTTTAAAGTCCACCAGGTTCCTGCTGGCCATTTGCAGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGGTGAAGTGAGAAGATCCCTTGAGCCCAAGAGTTCGAAACCAGCCTGGGCAACGTAAGGAGACCCCATGTCTATTAGAAAAACAAAAAAAGGAAAGAGCCTATGTGACCTGCGCTAAGTGGACGTTGGCCCTCTTCCGTGGTGTCTCGGAGGTGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTTGTACTTTTTATGAGAAGCGTATGGCCACAGAAGTTGCTGTTGACGCTCTGGGTGAAGAATGGAAGGGTTACGTGGTCGGAATCAGTGGTGGGAACAATAAACAAGGTTTCCCCTTGAAACAGGGTGTCTTGACCCATGGCCGTGTCCACTTGCTACTGAGTAAGGGGCATTCCTATTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAGATCAGTTCATGGTTGCATCGTGGATGCCAATCTGAGTGTTCTCAACTTGGTTATTGTAAAAAAAAGGAGAGAAGGGTATTCCTGGACTGACTGAGACTATGATGCCTCGTCACCTGGGGCCCAGTACAGCTAGCAGAATCCGTAAACTTTTCAGTCTCTCTAAAGAAAATGATGTCTGCCAGTATGTTGTAAAAAAGCCCTTAAACAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGCCTTGTCACTCCACATGTCCTGCAGCACAAACAGCGGCGTATTGCTCTGAAGCAGCCGCATATTAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGAAGCACCAGGGACAAATCGTGAAGAGACGCAGACTGTCCTCTCTGCGAGCTTCCACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAGATCAGATTCGCAAAAAAAAAAAAAAACCCACAAGGCCCTGTGTGACCAGGCCTCTGCTGACCTTTCCACCTCATCTCTGGCCACTCATGTGATCCTCCCAGCCAGACTTAGCTACTTGAAATTCTCCAGAAGTACCACCAGTTCTTTACACATCTGTTCCCTCTCCCAGCACTGCTCTTCCCCACAGCCTCCTCCTGCTTAACTCCTCACACCCTTCCAGTTTGGCCAACTCCTTCCTGATTCCCTGGGTCCCCCTCCCCATCTTGGCATTGTGATCATGACTTTGGGGTAACCTGTCTCTTGAAAGCAGGGCCAGATCTAACTTAGTTATGAGGTCTGACTCAGGGGCGAGGGTAATTTTTTTTTTCTTTTTTTGAGACAAAGTCCCGCTCCGTCCCCCAGGCTGAAGTGCAGTGGTACAATCTTGGCTCACTGCAACCTGCGGTTCCCCAGTTCAAGCAATTCCTGTGCCTCGGCCTCCCAATTAGCTGGGATTGCAGGTGCTTGCTACCCGTGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGTGTTTCACTATGTTGGCCAGGCTGGTCTCGAACTCCAGACCTCAAGTGATCCATCTGCCTTGGCCTCCCAAAGTGCTGAGATTACATGTGTGAGCCACCTCGACTGGCCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGATTTTTTTTCTTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGTA