ID
stringlengths
13
17
question
stringlengths
88
1.13k
answer
stringlengths
6
156
reference_sequence
stringlengths
4.1k
4.1k
variant_sequence
stringlengths
4.1k
4.1k
Task1_train_12000
A variant on Chromosome 7 in gene MET (MET proto-oncogene, receptor tyrosine kinase) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Pediatric hepatocellular carcinoma
CTATAATACTAATCCTATTTTTAATGGTAACATTTTTATTTCATTTCAGCTTATTAGAATATAGAGAACTTATTTTATTATAGTTCTTCATGTGGGTTAACTTTATTTTCATATTTTAAAATACTATGTCATCCTTTAAAAAAATTTATTTGATGAGGCCGATGTTACTCACCTTTTCAGTGGTTCCACTGTGGTTGAATATTTTATTAGGTTAGGCTTTAATATGAGTCATATCATCTACAACTTATTCATGAATTAAATAATCACATTGCTTATATCCTTGGGTGAAATGTGTTGCATCTACATATATATTTACAAAC...
CTATAATACTAATCCTATTTTTAATGGTAACATTTTTATTTCATTTCAGCTTATTAGAATATAGAGAACTTATTTTATTATAGTTCTTCATGTGGGTTAACTTTATTTTCATATTTTAAAATACTATGTCATCCTTTAAAAAAATTTATTTGATGAGGCCGATGTTACTCACCTTTTCAGTGGTTCCACTGTGGTTGAATATTTTATTAGGTTAGGCTTTAATATGAGTCATATCATCTACAACTTATTCATGAATTAAATAATCACATTGCTTATATCCTTGGGTGAAATGTGTTGCATCTACATATATATTTACAAAC...
Task1_train_12001
This gene mutation involves MET (MET proto-oncogene, receptor tyrosine kinase) on Chromosome 7. Is it associated with any clinical condition, or is it benign?
Pathogenic; Papillary renal cell carcinoma type 1
CACACACCCTCATCCCATTAGAATGGAAGCTCATGAGGGTAGGATTTTTGTGTATTTTGTTCACTGCTGTGGCTCCAACACCTAAAACAGTGTTTAGCACATAGACTCGCAGTAAATAATTGTTGAATGAATCAGCTAAGGGTTACAAAAAAAGGTTCTTAGCCTCTTGCAAGTGGTAGATTTTTTTCTTGACATTTATGCCAGGACCTAAAAGTCACCAGGCCAGGACCAGGGAGGGTGGGAATAAGAATCTCAAGAACTGAATTCATAGAAGGCCTCAAGCTCCGTCTCGGTTCCTGCTCTCCAAGTCTCTGTGGGAG...
CACACACCCTCATCCCATTAGAATGGAAGCTCATGAGGGTAGGATTTTTGTGTATTTTGTTCACTGCTGTGGCTCCAACACCTAAAACAGTGTTTAGCACATAGACTCGCAGTAAATAATTGTTGAATGAATCAGCTAAGGGTTACAAAAAAAGGTTCTTAGCCTCTTGCAAGTGGTAGATTTTTTTCTTGACATTTATGCCAGGACCTAAAAGTCACCAGGCCAGGACCAGGGAGGGTGGGAATAAGAATCTCAAGAACTGAATTCATAGAAGGCCTCAAGCTCCGTCTCGGTTCCTGCTCTCCAAGTCTCTGTGGGAG...
Task1_train_12002
Here is a variant affecting MET (MET proto-oncogene, receptor tyrosine kinase) on Chromosome 7. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Papillary renal cell carcinoma type 1
AATGGAAGCTCATGAGGGTAGGATTTTTGTGTATTTTGTTCACTGCTGTGGCTCCAACACCTAAAACAGTGTTTAGCACATAGACTCGCAGTAAATAATTGTTGAATGAATCAGCTAAGGGTTACAAAAAAAGGTTCTTAGCCTCTTGCAAGTGGTAGATTTTTTTCTTGACATTTATGCCAGGACCTAAAAGTCACCAGGCCAGGACCAGGGAGGGTGGGAATAAGAATCTCAAGAACTGAATTCATAGAAGGCCTCAAGCTCCGTCTCGGTTCCTGCTCTCCAAGTCTCTGTGGGAGGTAATGAAGTTGATCAAAAGC...
AATGGAAGCTCATGAGGGTAGGATTTTTGTGTATTTTGTTCACTGCTGTGGCTCCAACACCTAAAACAGTGTTTAGCACATAGACTCGCAGTAAATAATTGTTGAATGAATCAGCTAAGGGTTACAAAAAAAGGTTCTTAGCCTCTTGCAAGTGGTAGATTTTTTTCTTGACATTTATGCCAGGACCTAAAAGTCACCAGGCCAGGACCAGGGAGGGTGGGAATAAGAATCTCAAGAACTGAATTCATAGAAGGCCTCAAGCTCCGTCTCGGTTCCTGCTCTCCAAGTCTCTGTGGGAGGTAATGAAGTTGATCAAAAGC...
Task1_train_12003
A mutation on Chromosome 7 affecting MET (MET proto-oncogene, receptor tyrosine kinase) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; Pediatric hepatocellular carcinoma
TCTCCTGTTCTGTTGGCCTCATCATACCTGGAAAATAATAAAACTACATTTTAAAACACCTCCATTTTCCCATCTGGAAAATGGAGCCTGTAACACCTGCCTGACAGAAGTGTAGAAGTAGCTGTAATTTATGAAAACAATTAGCCTGGTGTGTTGCATACAATAAATACTTAACAAATGGTTGATCTGTCAATGGGGCACACTTTTTGTTGTTGTTGTTTTGTTTTTTGTTTTTGGAGACAAGGTCTCTGTCACCCAGGCTGGAGTGCAGTGGCACAGTCATAGTGCACTGCAGTATCCAACTCCTGGGCTCAAGCAAT...
TCTCCTGTTCTGTTGGCCTCATCATACCTGGAAAATAATAAAACTACATTTTAAAACACCTCCATTTTCCCATCTGGAAAATGGAGCCTGTAACACCTGCCTGACAGAAGTGTAGAAGTAGCTGTAATTTATGAAAACAATTAGCCTGGTGTGTTGCATACAATAAATACTTAACAAATGGTTGATCTGTCAATGGGGCACACTTTTTGTTGTTGTTGTTTTGTTTTTTGTTTTTGGAGACAAGGTCTCTGTCACCCAGGCTGGAGTGCAGTGGCACAGTCATAGTGCACTGCAGTATCCAACTCCTGGGCTCAAGCAAT...
Task1_train_12004
This genomic variant is located on Chromosome 7, within the CFTR (CF transmembrane conductance regulator) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Cystic fibrosis
AGTAAGAACTCAAGTAACTGTTTCACTCTTTCCAGAAGGAGATTGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTT...
AGTAAGAACTCAAGTAACTGTTTCACTCTTTCCAGAAGGAGATTGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTT...
Task1_train_12005
The following genetic variant occurs in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Cystic fibrosis
GTAAGAACTCAAGTAACTGTTTCACTCTTTCCAGAAGGAGATTGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTTT...
GTAAGAACTCAAGTAACTGTTTCACTCTTTCCAGAAGGAGATTGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTTT...
Task1_train_12006
Consider this mutation in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Is this a benign change or a disease-causing variant?
Pathogenic; Cystic fibrosis
GTAAGAACTCAAGTAACTGTTTCACTCTTTCCAGAAGGAGATTGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTTT...
GTAAGAACTCAAGTAACTGTTTCACTCTTTCCAGAAGGAGATTGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTTT...
Task1_train_12007
With a mutation on Chromosome 7 in gene CFTR (CF transmembrane conductance regulator), classify this variant as benign or pathogenic. Include the disease if it's pathogenic.
Pathogenic; Cystic fibrosis
TAAGAACTCAAGTAACTGTTTCACTCTTTCCAGAAGGAGATTGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTTTG...
TAAGAACTCAAGTAACTGTTTCACTCTTTCCAGAAGGAGATTGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTTTG...
Task1_train_12008
Here’s a variant in CFTR (CF transmembrane conductance regulator) located on Chromosome 7. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Cystic fibrosis
GGAGATTGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTTTGTCATAATGGAGAGATGAAAACACAGGTAGAGGATT...
GGAGATTGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTTTGTCATAATGGAGAGATGAAAACACAGGTAGAGGATT...
Task1_train_12009
A variant was discovered on Chromosome 7, affecting CFTR (CF transmembrane conductance regulator). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Cystic fibrosis
TGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTTTGTCATAATGGAGAGATGAAAACACAGGTAGAGGATTTCAAAC...
TGGCTGAAAAATATTTGGAGTCTCCTCCAGCCATATTCCTTGGTCAGCTTCTATGATCCTCTTTGGAGCTTAATTCTTAATCCCTTTATTTTCACTTGCTTGTTGATAACAAAGAAGAACTAATTATTAATTTATTTCAAAATGCATGTATTATATTTGATGGGCCACACTAACAGTTATAAACCAAACAACAGATTGGGAATGGGGAAGTGGATGTGGTGAGTTCAATCACATGTCTGGGAAAAGTCAATAGTGAAGACAGAGTCTCACAATTTTTTGTCATAATGGAGAGATGAAAACACAGGTAGAGGATTTCAAAC...
Task1_train_12010
Located on Chromosome 7, this mutation impacts CFTR (CF transmembrane conductance regulator). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Cystic fibrosis
TGGTAAAAGAATGAATGAAGTCAAAAGAATGTGGAAAGACCTAGGCTTTGCCATTTAGTAAAGTTTAGCATCTCTAAGCCTCCATCTCTTTATCAATAAAATTGAGCAATGATCCCTTTTAGTTCTACCCATTTAAGAAGATTTTCAAATGAAAACCACAACCTGCTCATGTTTATGAAGGCACTTTGGAAAGCGCTAAATACACGGGTTTTTATTAGTAGTAAACACTTACTTCACCTTTTTCACTTCTTGACTTTAGTTTACAAGGGCTCATAATCTAAATTATATCATAAATTGCTGTCCCAGATTTTTTTACAGCC...
TGGTAAAAGAATGAATGAAGTCAAAAGAATGTGGAAAGACCTAGGCTTTGCCATTTAGTAAAGTTTAGCATCTCTAAGCCTCCATCTCTTTATCAATAAAATTGAGCAATGATCCCTTTTAGTTCTACCCATTTAAGAAGATTTTCAAATGAAAACCACAACCTGCTCATGTTTATGAAGGCACTTTGGAAAGCGCTAAATACACGGGTTTTTATTAGTAGTAAACACTTACTTCACCTTTTTCACTTCTTGACTTTAGTTTACAAGGGCTCATAATCTAAATTATATCATAAATTGCTGTCCCAGATTTTTTTACAGCC...
Task1_train_12011
This variant impacts the gene CFTR (CF transmembrane conductance regulator) on Chromosome 7. Is the change likely to result in a pathogenic outcome?
Pathogenic; Cystic fibrosis
ATTTAGTAAAGTTTAGCATCTCTAAGCCTCCATCTCTTTATCAATAAAATTGAGCAATGATCCCTTTTAGTTCTACCCATTTAAGAAGATTTTCAAATGAAAACCACAACCTGCTCATGTTTATGAAGGCACTTTGGAAAGCGCTAAATACACGGGTTTTTATTAGTAGTAAACACTTACTTCACCTTTTTCACTTCTTGACTTTAGTTTACAAGGGCTCATAATCTAAATTATATCATAAATTGCTGTCCCAGATTTTTTTACAGCCTAATTGCCACCTGTATGTTCGACTTTCCTTCTGTTCTTTATGTTAGATACTG...
ATTTAGTAAAGTTTAGCATCTCTAAGCCTCCATCTCTTTATCAATAAAATTGAGCAATGATCCCTTTTAGTTCTACCCATTTAAGAAGATTTTCAAATGAAAACCACAACCTGCTCATGTTTATGAAGGCACTTTGGAAAGCGCTAAATACACGGGTTTTTATTAGTAGTAAACACTTACTTCACCTTTTTCACTTCTTGACTTTAGTTTACAAGGGCTCATAATCTAAATTATATCATAAATTGCTGTCCCAGATTTTTTTACAGCCTAATTGCCACCTGTATGTTCGACTTTCCTTCTGTTCTTTATGTTAGATACTG...
Task1_train_12012
This genomic variant is located on Chromosome 7, within the CFTR (CF transmembrane conductance regulator) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Cystic fibrosis
TAAAGTTTAGCATCTCTAAGCCTCCATCTCTTTATCAATAAAATTGAGCAATGATCCCTTTTAGTTCTACCCATTTAAGAAGATTTTCAAATGAAAACCACAACCTGCTCATGTTTATGAAGGCACTTTGGAAAGCGCTAAATACACGGGTTTTTATTAGTAGTAAACACTTACTTCACCTTTTTCACTTCTTGACTTTAGTTTACAAGGGCTCATAATCTAAATTATATCATAAATTGCTGTCCCAGATTTTTTTACAGCCTAATTGCCACCTGTATGTTCGACTTTCCTTCTGTTCTTTATGTTAGATACTGGGATAG...
TAAAGTTTAGCATCTCTAAGCCTCCATCTCTTTATCAATAAAATTGAGCAATGATCCCTTTTAGTTCTACCCATTTAAGAAGATTTTCAAATGAAAACCACAACCTGCTCATGTTTATGAAGGCACTTTGGAAAGCGCTAAATACACGGGTTTTTATTAGTAGTAAACACTTACTTCACCTTTTTCACTTCTTGACTTTAGTTTACAAGGGCTCATAATCTAAATTATATCATAAATTGCTGTCCCAGATTTTTTTACAGCCTAATTGCCACCTGTATGTTCGACTTTCCTTCTGTTCTTTATGTTAGATACTGGGATAG...
Task1_train_12013
A mutation on Chromosome 7 affecting CFTR (CF transmembrane conductance regulator) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; Cystic fibrosis
ATCTCTAAGCCTCCATCTCTTTATCAATAAAATTGAGCAATGATCCCTTTTAGTTCTACCCATTTAAGAAGATTTTCAAATGAAAACCACAACCTGCTCATGTTTATGAAGGCACTTTGGAAAGCGCTAAATACACGGGTTTTTATTAGTAGTAAACACTTACTTCACCTTTTTCACTTCTTGACTTTAGTTTACAAGGGCTCATAATCTAAATTATATCATAAATTGCTGTCCCAGATTTTTTTACAGCCTAATTGCCACCTGTATGTTCGACTTTCCTTCTGTTCTTTATGTTAGATACTGGGATAGTATGCACCAGG...
ATCTCTAAGCCTCCATCTCTTTATCAATAAAATTGAGCAATGATCCCTTTTAGTTCTACCCATTTAAGAAGATTTTCAAATGAAAACCACAACCTGCTCATGTTTATGAAGGCACTTTGGAAAGCGCTAAATACACGGGTTTTTATTAGTAGTAAACACTTACTTCACCTTTTTCACTTCTTGACTTTAGTTTACAAGGGCTCATAATCTAAATTATATCATAAATTGCTGTCCCAGATTTTTTTACAGCCTAATTGCCACCTGTATGTTCGACTTTCCTTCTGTTCTTTATGTTAGATACTGGGATAGTATGCACCAGG...
Task1_train_12014
Consider a variant on Chromosome 7 in gene CFTR, LOC113664106 (CF transmembrane conductance regulator| CFTR intron 2 DNase I hypersensitive site). Determine its clinical classification and disease relevance.
Pathogenic; Cystic fibrosis
CCAGATGGTTGAAGAACATTAACCTATCTGGCTCAATTTTGTGACCATGGATTGAATCCTCTACATAACTGCAGTGTGCAAACCACACATCCGTTCCAAGATTGTAGTCAGGATATGAACTTTTTAAGAATAAAACTTCTTCCCTTCTGATCTGGGCCTGGTATGTGGTCCTACTAGAACCACATCACCTACTCTTGGTGCTAACAATTTGTGGCACCAAGTTGTTCAAGTTTCACCCATTAAAGAAATTCCCCGACCTTGCCTTCTCCTCAGGTAACTACCCCATTCTATTTTTTCTTTCATAGCTAACATTCTCTGCT...
CCAGATGGTTGAAGAACATTAACCTATCTGGCTCAATTTTGTGACCATGGATTGAATCCTCTACATAACTGCAGTGTGCAAACCACACATCCGTTCCAAGATTGTAGTCAGGATATGAACTTTTTAAGAATAAAACTTCTTCCCTTCTGATCTGGGCCTGGTATGTGGTCCTACTAGAACCACATCACCTACTCTTGGTGCTAACAATTTGTGGCACCAAGTTGTTCAAGTTTCACCCATTAAAGAAATTCCCCGACCTTGCCTTCTCCTCAGGTAACTACCCCATTCTATTTTTTCTTTCATAGCTAACATTCTCTGCT...
Task1_train_12015
Given this context: Chromosome 7, gene LOC113664106, CFTR (CFTR intron 2 DNase I hypersensitive site| CF transmembrane conductance regulator) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; Cystic fibrosis
TGAAGAACATTAACCTATCTGGCTCAATTTTGTGACCATGGATTGAATCCTCTACATAACTGCAGTGTGCAAACCACACATCCGTTCCAAGATTGTAGTCAGGATATGAACTTTTTAAGAATAAAACTTCTTCCCTTCTGATCTGGGCCTGGTATGTGGTCCTACTAGAACCACATCACCTACTCTTGGTGCTAACAATTTGTGGCACCAAGTTGTTCAAGTTTCACCCATTAAAGAAATTCCCCGACCTTGCCTTCTCCTCAGGTAACTACCCCATTCTATTTTTTCTTTCATAGCTAACATTCTCTGCTCTCCTGGTC...
TGAAGAACATTAACCTATCTGGCTCAATTTTGTGACCATGGATTGAATCCTCTACATAACTGCAGTGTGCAAACCACACATCCGTTCCAAGATTGTAGTCAGGATATGAACTTTTTAAGAATAAAACTTCTTCCCTTCTGATCTGGGCCTGGTATGTGGTCCTACTAGAACCACATCACCTACTCTTGGTGCTAACAATTTGTGGCACCAAGTTGTTCAAGTTTCACCCATTAAAGAAATTCCCCGACCTTGCCTTCTCCTCAGGTAACTACCCCATTCTATTTTTTCTTTCATAGCTAACATTCTCTGCTCTCCTGGTC...
Task1_train_12016
A variant was discovered in gene CFTR (CF transmembrane conductance regulator), Chromosome 7. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Cystic fibrosis
CACATCCGTTCCAAGATTGTAGTCAGGATATGAACTTTTTAAGAATAAAACTTCTTCCCTTCTGATCTGGGCCTGGTATGTGGTCCTACTAGAACCACATCACCTACTCTTGGTGCTAACAATTTGTGGCACCAAGTTGTTCAAGTTTCACCCATTAAAGAAATTCCCCGACCTTGCCTTCTCCTCAGGTAACTACCCCATTCTATTTTTTCTTTCATAGCTAACATTCTCTGCTCTCCTGGTCTCTCTACTTCACTTTCATTTACATCTCAGCTCCTGAAGTATGGTTTCCACCATGTTCCTAAAACTACATTGCCCAG...
CACATCCGTTCCAAGATTGTAGTCAGGATATGAACTTTTTAAGAATAAAACTTCTTCCCTTCTGATCTGGGCCTGGTATGTGGTCCTACTAGAACCACATCACCTACTCTTGGTGCTAACAATTTGTGGCACCAAGTTGTTCAAGTTTCACCCATTAAAGAAATTCCCCGACCTTGCCTTCTCCTCAGGTAACTACCCCATTCTATTTTTTCTTTCATAGCTAACATTCTCTGCTCTCCTGGTCTCTCTACTTCACTTTCATTTACATCTCAGCTCCTGAAGTATGGTTTCCACCATGTTCCTAAAACTACATTGCCCAG...
Task1_train_12017
This alteration occurs within gene CFTR (CF transmembrane conductance regulator) located on Chromosome 7. Is it associated with a disease or is it a benign variant?
Pathogenic; Cystic fibrosis
CACATCCGTTCCAAGATTGTAGTCAGGATATGAACTTTTTAAGAATAAAACTTCTTCCCTTCTGATCTGGGCCTGGTATGTGGTCCTACTAGAACCACATCACCTACTCTTGGTGCTAACAATTTGTGGCACCAAGTTGTTCAAGTTTCACCCATTAAAGAAATTCCCCGACCTTGCCTTCTCCTCAGGTAACTACCCCATTCTATTTTTTCTTTCATAGCTAACATTCTCTGCTCTCCTGGTCTCTCTACTTCACTTTCATTTACATCTCAGCTCCTGAAGTATGGTTTCCACCATGTTCCTAAAACTACATTGCCCAG...
CACATCCGTTCCAAGATTGTAGTCAGGATATGAACTTTTTAAGAATAAAACTTCTTCCCTTCTGATCTGGGCCTGGTATGTGGTCCTACTAGAACCACATCACCTACTCTTGGTGCTAACAATTTGTGGCACCAAGTTGTTCAAGTTTCACCCATTAAAGAAATTCCCCGACCTTGCCTTCTCCTCAGGTAACTACCCCATTCTATTTTTTCTTTCATAGCTAACATTCTCTGCTCTCCTGGTCTCTCTACTTCACTTTCATTTACATCTCAGCTCCTGAAGTATGGTTTCCACCATGTTCCTAAAACTACATTGCCCAG...
Task1_train_12018
Located on Chromosome 7, this mutation impacts CFTR (CF transmembrane conductance regulator). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Cystic fibrosis
TGTAGTCAGGATATGAACTTTTTAAGAATAAAACTTCTTCCCTTCTGATCTGGGCCTGGTATGTGGTCCTACTAGAACCACATCACCTACTCTTGGTGCTAACAATTTGTGGCACCAAGTTGTTCAAGTTTCACCCATTAAAGAAATTCCCCGACCTTGCCTTCTCCTCAGGTAACTACCCCATTCTATTTTTTCTTTCATAGCTAACATTCTCTGCTCTCCTGGTCTCTCTACTTCACTTTCATTTACATCTCAGCTCCTGAAGTATGGTTTCCACCATGTTCCTAAAACTACATTGCCCAGGGTCACTAGAGACCTCT...
TGTAGTCAGGATATGAACTTTTTAAGAATAAAACTTCTTCCCTTCTGATCTGGGCCTGGTATGTGGTCCTACTAGAACCACATCACCTACTCTTGGTGCTAACAATTTGTGGCACCAAGTTGTTCAAGTTTCACCCATTAAAGAAATTCCCCGACCTTGCCTTCTCCTCAGGTAACTACCCCATTCTATTTTTTCTTTCATAGCTAACATTCTCTGCTCTCCTGGTCTCTCTACTTCACTTTCATTTACATCTCAGCTCCTGAAGTATGGTTTCCACCATGTTCCTAAAACTACATTGCCCAGGGTCACTAGAGACCTCT...
Task1_train_12019
Located on Chromosome 7, this mutation impacts CFTR (CF transmembrane conductance regulator). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Cystic fibrosis
AAAAGTCAGGAAACAACAGGTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATG...
AAAAGTCAGGAAACAACAGGTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATG...
Task1_train_12020
The gene CFTR (CF transmembrane conductance regulator) is located on Chromosome 7, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Cystic fibrosis
GTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAA...
GTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAA...
Task1_train_12021
The following genetic variant occurs in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; CFTR-related disorder
CTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAA...
CTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAA...
Task1_train_12022
A mutation in CFTR (CF transmembrane conductance regulator), located on Chromosome 7, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Cystic fibrosis
CTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAA...
CTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAA...
Task1_train_12023
Here is a mutation in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Cystic fibrosis
CTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAA...
CTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAA...
Task1_train_12024
Here is a mutation in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Cystic fibrosis
ATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGT...
ATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGT...
Task1_train_12025
A variant was discovered on Chromosome 7, affecting CFTR (CF transmembrane conductance regulator). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Congenital bilateral aplasia of vas deferens from CFTR mutation
AATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCT...
AATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCT...
Task1_train_12026
Here is a mutation in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Bronchiectasis with or without elevated sweat chloride 1
AATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCT...
AATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCT...
Task1_train_12027
A change on Chromosome 7 affects gene CFTR (CF transmembrane conductance regulator). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Hereditary pancreatitis
AATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCT...
AATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCT...
Task1_train_12028
Consider this mutation in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Is this a benign change or a disease-causing variant?
Pathogenic; Cystic fibrosis
AATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCT...
AATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCT...
Task1_train_12029
The gene CFTR (CF transmembrane conductance regulator), on Chromosome 7, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; Cystic fibrosis
AATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCT...
AATAGGAACACTTTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCT...
Task1_train_12030
Gene CFTR (CF transmembrane conductance regulator) on Chromosome 7 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Bronchiectasis with or without elevated sweat chloride 1
TTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACAT...
TTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACAT...
Task1_train_12031
Here is a genetic alteration in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Cystic fibrosis
TTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACAT...
TTTACACTGTTGGTGGGACTGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACAT...
Task1_train_12032
This genomic variant is located on Chromosome 7, within the CFTR (CF transmembrane conductance regulator) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Cystic fibrosis
GTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATC...
GTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATC...
Task1_train_12033
Gene CFTR (CF transmembrane conductance regulator) on Chromosome 7 is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; Cystic fibrosis
ACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTC...
ACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTC...
Task1_train_12034
A change on Chromosome 7 affects gene CFTR (CF transmembrane conductance regulator). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Cystic fibrosis
ACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTC...
ACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTC...
Task1_train_12035
This sequence change occurs on Chromosome 7, altering CFTR (CF transmembrane conductance regulator). What is the medical significance of this variant — is it benign or linked to a disease?
Pathogenic; Cystic fibrosis
GTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAA...
GTGGCGATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAA...
Task1_train_12036
A variant on Chromosome 7 in gene CFTR (CF transmembrane conductance regulator) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Cystic fibrosis
TGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAA...
TGACCCAGCCATCCCATTACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAA...
Task1_train_12037
Given this context: Chromosome 7, gene CFTR (CF transmembrane conductance regulator) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; CFTR-related disorder
TACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGA...
TACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGA...
Task1_train_12038
This genomic variant is located on Chromosome 7, within the CFTR (CF transmembrane conductance regulator) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Cystic fibrosis
TACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGA...
TACTGGGTATATACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGA...
Task1_train_12039
Gene CFTR (CF transmembrane conductance regulator) on Chromosome 7 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Congenital bilateral aplasia of vas deferens from CFTR mutation
ACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGG...
ACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGG...
Task1_train_12040
Gene CFTR (CF transmembrane conductance regulator), found on Chromosome 7, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Bronchiectasis with or without elevated sweat chloride 1
ACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGG...
ACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGG...
Task1_train_12041
Here is a genetic alteration in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Hereditary pancreatitis
ACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGG...
ACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGG...
Task1_train_12042
This sequence variant lies in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Cystic fibrosis
ACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGG...
ACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGG...
Task1_train_12043
This gene mutation involves CFTR (CF transmembrane conductance regulator) on Chromosome 7. Is it associated with any clinical condition, or is it benign?
Pathogenic; Cystic fibrosis
ACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGG...
ACCCAAAGGACTATAAATCATGCTGCTATAAAGACACATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGG...
Task1_train_12044
A variant was discovered on Chromosome 7, affecting CFTR (CF transmembrane conductance regulator). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Cystic fibrosis
CATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGGAATATCACACTCTGGGGACTGTGGTGGGGTCGGGGG...
CATGCACACGTATGTTTATTGCGGCACTATTCACAATAGGAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATACAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGAGACATGGATGAAATTGGAAACCATCATTCTCAGTAAACTATCGCAAGAACAAAAAACCAAACACCGCATATTCTCACTCATAGGTGGGAATTGAACAATGAGATCACATGGACACAGGAAGGGGAATATCACACTCTGGGGACTGTGGTGGGGTCGGGGG...
Task1_train_12045
This alteration in CFTR (CF transmembrane conductance regulator) on Chromosome 7 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Cystic fibrosis
GGAATGTGGAATCTACACAGTTGGCATATCAGAGAAGGTTGAATTCAGTTTAATAAATGTTTATAGAAAGTGCTTGTTATCATAATGATAATAGCTCAGGATGTGCATGACAAGCTTTTAAGCGATTGGGTACACTATCTCATTTGATCTTCTGCACAACTATTAATGGTAGGTACTATTATCCCTATCTTATGGATAAGTAAACTAAGATTTAAAAAGTACAGAACATGGTGTGAACACTGCTTCAAAATTTCTAAAATAGGTAAATCACGATCTCTAAACTGGAGGGTTGTCCAACCACTAGGGACAATAGAGTACTG...
GGAATGTGGAATCTACACAGTTGGCATATCAGAGAAGGTTGAATTCAGTTTAATAAATGTTTATAGAAAGTGCTTGTTATCATAATGATAATAGCTCAGGATGTGCATGACAAGCTTTTAAGCGATTGGGTACACTATCTCATTTGATCTTCTGCACAACTATTAATGGTAGGTACTATTATCCCTATCTTATGGATAAGTAAACTAAGATTTAAAAAGTACAGAACATGGTGTGAACACTGCTTCAAAATTTCTAAAATAGGTAAATCACGATCTCTAAACTGGAGGGTTGTCCAACCACTAGGGACAATAGAGTACTG...
Task1_train_12046
With a mutation on Chromosome 7 in gene CFTR (CF transmembrane conductance regulator), classify this variant as benign or pathogenic. Include the disease if it's pathogenic.
Pathogenic; Hereditary pancreatitis
TTGAATTCAGTTTAATAAATGTTTATAGAAAGTGCTTGTTATCATAATGATAATAGCTCAGGATGTGCATGACAAGCTTTTAAGCGATTGGGTACACTATCTCATTTGATCTTCTGCACAACTATTAATGGTAGGTACTATTATCCCTATCTTATGGATAAGTAAACTAAGATTTAAAAAGTACAGAACATGGTGTGAACACTGCTTCAAAATTTCTAAAATAGGTAAATCACGATCTCTAAACTGGAGGGTTGTCCAACCACTAGGGACAATAGAGTACTGATATTTAGTGGTCAGACTGTAATGCGGGAAGAGACAGG...
TTGAATTCAGTTTAATAAATGTTTATAGAAAGTGCTTGTTATCATAATGATAATAGCTCAGGATGTGCATGACAAGCTTTTAAGCGATTGGGTACACTATCTCATTTGATCTTCTGCACAACTATTAATGGTAGGTACTATTATCCCTATCTTATGGATAAGTAAACTAAGATTTAAAAAGTACAGAACATGGTGTGAACACTGCTTCAAAATTTCTAAAATAGGTAAATCACGATCTCTAAACTGGAGGGTTGTCCAACCACTAGGGACAATAGAGTACTGATATTTAGTGGTCAGACTGTAATGCGGGAAGAGACAGG...
Task1_train_12047
The gene CFTR (CF transmembrane conductance regulator) on Chromosome 7 contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Cystic fibrosis
TATCATAATGATAATAGCTCAGGATGTGCATGACAAGCTTTTAAGCGATTGGGTACACTATCTCATTTGATCTTCTGCACAACTATTAATGGTAGGTACTATTATCCCTATCTTATGGATAAGTAAACTAAGATTTAAAAAGTACAGAACATGGTGTGAACACTGCTTCAAAATTTCTAAAATAGGTAAATCACGATCTCTAAACTGGAGGGTTGTCCAACCACTAGGGACAATAGAGTACTGATATTTAGTGGTCAGACTGTAATGCGGGAAGAGACAGGCATGGGCTAAACGGGTGTAGAGATCAAATAAGGGGCAGG...
TATCATAATGATAATAGCTCAGGATGTGCATGACAAGCTTTTAAGCGATTGGGTACACTATCTCATTTGATCTTCTGCACAACTATTAATGGTAGGTACTATTATCCCTATCTTATGGATAAGTAAACTAAGATTTAAAAAGTACAGAACATGGTGTGAACACTGCTTCAAAATTTCTAAAATAGGTAAATCACGATCTCTAAACTGGAGGGTTGTCCAACCACTAGGGACAATAGAGTACTGATATTTAGTGGTCAGACTGTAATGCGGGAAGAGACAGGCATGGGCTAAACGGGTGTAGAGATCAAATAAGGGGCAGG...
Task1_train_12048
This gene mutation involves CFTR (CF transmembrane conductance regulator) on Chromosome 7. Is it associated with any clinical condition, or is it benign?
Pathogenic; Cystic fibrosis
ATAATGATAATAGCTCAGGATGTGCATGACAAGCTTTTAAGCGATTGGGTACACTATCTCATTTGATCTTCTGCACAACTATTAATGGTAGGTACTATTATCCCTATCTTATGGATAAGTAAACTAAGATTTAAAAAGTACAGAACATGGTGTGAACACTGCTTCAAAATTTCTAAAATAGGTAAATCACGATCTCTAAACTGGAGGGTTGTCCAACCACTAGGGACAATAGAGTACTGATATTTAGTGGTCAGACTGTAATGCGGGAAGAGACAGGCATGGGCTAAACGGGTGTAGAGATCAAATAAGGGGCAGGTTAG...
ATAATGATAATAGCTCAGGATGTGCATGACAAGCTTTTAAGCGATTGGGTACACTATCTCATTTGATCTTCTGCACAACTATTAATGGTAGGTACTATTATCCCTATCTTATGGATAAGTAAACTAAGATTTAAAAAGTACAGAACATGGTGTGAACACTGCTTCAAAATTTCTAAAATAGGTAAATCACGATCTCTAAACTGGAGGGTTGTCCAACCACTAGGGACAATAGAGTACTGATATTTAGTGGTCAGACTGTAATGCGGGAAGAGACAGGCATGGGCTAAACGGGTGTAGAGATCAAATAAGGGGCAGGTTAG...
Task1_train_12049
A sequence alteration has been identified in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Is it disease-inducing or harmless?
Pathogenic; Cystic fibrosis
CAATTTAGCTCAGTGGATTTCCCCCACTTCATATTGCTCTGATAATGTTTTGGAATTAACTGCCTTGATTCCTTCTTTTCTCTGCTTGTCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGAT...
CAATTTAGCTCAGTGGATTTCCCCCACTTCATATTGCTCTGATAATGTTTTGGAATTAACTGCCTTGATTCCTTCTTTTCTCTGCTTGTCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGAT...
Task1_train_12050
A genomic change on Chromosome 7 affects CFTR (CF transmembrane conductance regulator). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Cystic fibrosis
GATTTCCCCCACTTCATATTGCTCTGATAATGTTTTGGAATTAACTGCCTTGATTCCTTCTTTTCTCTGCTTGTCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAAT...
GATTTCCCCCACTTCATATTGCTCTGATAATGTTTTGGAATTAACTGCCTTGATTCCTTCTTTTCTCTGCTTGTCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAAT...
Task1_train_12051
This variant lies on Chromosome 7 and affects the gene CFTR (CF transmembrane conductance regulator). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Cystic fibrosis
ATTTCCCCCACTTCATATTGCTCTGATAATGTTTTGGAATTAACTGCCTTGATTCCTTCTTTTCTCTGCTTGTCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATG...
ATTTCCCCCACTTCATATTGCTCTGATAATGTTTTGGAATTAACTGCCTTGATTCCTTCTTTTCTCTGCTTGTCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATG...
Task1_train_12052
The gene CFTR (CF transmembrane conductance regulator) on Chromosome 7 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Cystic fibrosis
TTGCTCTGATAATGTTTTGGAATTAACTGCCTTGATTCCTTCTTTTCTCTGCTTGTCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAG...
TTGCTCTGATAATGTTTTGGAATTAACTGCCTTGATTCCTTCTTTTCTCTGCTTGTCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAG...
Task1_train_12053
This alteration occurs within gene CFTR (CF transmembrane conductance regulator) located on Chromosome 7. Is it associated with a disease or is it a benign variant?
Pathogenic; Cystic fibrosis
TTGCTCTGATAATGTTTTGGAATTAACTGCCTTGATTCCTTCTTTTCTCTGCTTGTCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAG...
TTGCTCTGATAATGTTTTGGAATTAACTGCCTTGATTCCTTCTTTTCTCTGCTTGTCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAG...
Task1_train_12054
This variant lies on Chromosome 7 and affects the gene CFTR (CF transmembrane conductance regulator). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; not specified
TCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAGGGATTCACTTGAAACTAATATTAGATAATTCCCAGTCAAAGTGATCTAATAGCAA...
TCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAGGGATTCACTTGAAACTAATATTAGATAATTCCCAGTCAAAGTGATCTAATAGCAA...
Task1_train_12055
The gene CFTR (CF transmembrane conductance regulator) on Chromosome 7 contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Cystic fibrosis
TCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAGGGATTCACTTGAAACTAATATTAGATAATTCCCAGTCAAAGTGATCTAATAGCAA...
TCTATACACTATTTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAGGGATTCACTTGAAACTAATATTAGATAATTCCCAGTCAAAGTGATCTAATAGCAA...
Task1_train_12056
Here’s a variant in CFTR (CF transmembrane conductance regulator) located on Chromosome 7. What is the predicted biological effect — harmless or disease-causing?
Pathogenic; Cystic fibrosis
TTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAGGGATTCACTTGAAACTAATATTAGATAATTCCCAGTCAAAGTGATCTAATAGCAAATCAATTCTTCA...
TTATTATTCTACACCATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAGGGATTCACTTGAAACTAATATTAGATAATTCCCAGTCAAAGTGATCTAATAGCAAATCAATTCTTCA...
Task1_train_12057
A mutation found in CFTR (CF transmembrane conductance regulator) on Chromosome 7 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Cystic fibrosis
ATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAGGGATTCACTTGAAACTAATATTAGATAATTCCCAGTCAAAGTGATCTAATAGCAAATCAATTCTTCAGTTTTATAGGCAAAG...
ATCTCAAATTCTAACTCCTCAAGAAAATCCTTCCAGATGATTTTTCTAACCAGGAGTTTTAACTTCCTTTTAACTACCCTATTACTTTCTACTTCCTTAACTCATCTATCATATTATATTTAGTTATTTATATACTAGGTCGCCTTGAAGAAGGGATTGTGTTTTCATAAATCTTAATAATCCCTGAGGCATCAAGTACAGTGATTTGCATTTACTAAATGCTCAACAAATATGTGAGGGATTCACTTGAAACTAATATTAGATAATTCCCAGTCAAAGTGATCTAATAGCAAATCAATTCTTCAGTTTTATAGGCAAAG...
Task1_train_12058
Mutation context: Chromosome 7, Gene CFTR (CF transmembrane conductance regulator). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Cystic fibrosis
GGCATGAAATTGTCACTCGAAAAGGCTAGAAGTGTTGACATAAATATGGGACAGCAAGAGTTGCTCCTACTCAAGAGAGCAAATATAATGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAA...
GGCATGAAATTGTCACTCGAAAAGGCTAGAAGTGTTGACATAAATATGGGACAGCAAGAGTTGCTCCTACTCAAGAGAGCAAATATAATGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAA...
Task1_train_12059
This alteration in CFTR (CF transmembrane conductance regulator) on Chromosome 7 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Cystic fibrosis
TACTCAAGAGAGCAAATATAATGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAAT...
TACTCAAGAGAGCAAATATAATGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAAT...
Task1_train_12060
This is a variant in CFTR (CF transmembrane conductance regulator), located on Chromosome 7. Is this mutation a likely cause of disease or not?
Pathogenic; Cystic fibrosis
ACTCAAGAGAGCAAATATAATGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATA...
ACTCAAGAGAGCAAATATAATGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATA...
Task1_train_12061
Given this variant in gene CFTR (CF transmembrane conductance regulator) on Chromosome 7, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Cystic fibrosis
GAGAGCAAATATAATGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTC...
GAGAGCAAATATAATGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTC...
Task1_train_12062
Given this context: Chromosome 7, gene CFTR (CF transmembrane conductance regulator) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; Cystic fibrosis
AAATATAATGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTCAACAAC...
AAATATAATGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTCAACAAC...
Task1_train_12063
A variant affecting Chromosome 7, within the gene CFTR (CF transmembrane conductance regulator), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Cystic fibrosis
TGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTCAACAACAGTTCAAC...
TGTTCTGGAAGAGATTGGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTCAACAACAGTTCAAC...
Task1_train_12064
A change on Chromosome 7 affects gene CFTR (CF transmembrane conductance regulator). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Cystic fibrosis
GGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTCAACAACAGTTCAACAAATTTAACATTTTTA...
GGCAGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTCAACAACAGTTCAACAAATTTAACATTTTTA...
Task1_train_12065
A variant was discovered on Chromosome 7, affecting CFTR (CF transmembrane conductance regulator). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Cystic fibrosis
AGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTCAACAACAGTTCAACAAATTTAACATTTTTATAA...
AGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTCAACAACAGTTCAACAAATTTAACATTTTTATAA...
Task1_train_12066
Here is a genetic alteration in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Based on the data, is it a benign variant or a cause of disease?
Pathogenic; Cystic fibrosis
AGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTCAACAACAGTTCAACAAATTTAACATTTTTATAA...
AGAATTCACATCAAAGGAGTGATTACTTCAGCCTGGGCCACTGTTGTACTGGTCAAAAGGCTGTGCAAAGCTCTCTGAAAATCCACTCTTTTATTGCTCTTTAGTAATAAAGTCACTTTCAATTTTAAAAATAACAAACTGATATATTTTTATGACTCATAAAATGTTAGCAATTATATTATGGAGAATCTACTTTCTGGGTGATTCTTACAAATGTTCTTGGATCTATTTTTTTTTCTTATAGTACCTATTCTTCCCATTTTTCTCAGCTCTAGTTAATATATTTCAACAACAGTTCAACAAATTTAACATTTTTATAA...
Task1_train_12067
Gene CFTR (CF transmembrane conductance regulator), found on Chromosome 7, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Cystic fibrosis
AAAATAACATCCTGAATTTTATTGTTATTGTTTTTTATAGAACAGAACTGAAACTGACTCGGAAGGCAGCCTATGTGAGATACTTCAATAGCTCAGCCTTCTTCTTCTCAGGGTTCTTTGTGGTGTTTTTATCTGTGCTTCCCTATGCACTAATCAAAGGAATCATCCTCCGGAAAATATTCACCACCATCTCATTCTGCATTGTTCTGCGCATGGCGGTCACTCGGCAATTTCCCTGGGCTGTACAAACATGGTATGACTCTCTTGGAGCAATAAACAAAATACAGGTAATGTACCATAATGCTGCATTATATACTATG...
AAAATAACATCCTGAATTTTATTGTTATTGTTTTTTATAGAACAGAACTGAAACTGACTCGGAAGGCAGCCTATGTGAGATACTTCAATAGCTCAGCCTTCTTCTTCTCAGGGTTCTTTGTGGTGTTTTTATCTGTGCTTCCCTATGCACTAATCAAAGGAATCATCCTCCGGAAAATATTCACCACCATCTCATTCTGCATTGTTCTGCGCATGGCGGTCACTCGGCAATTTCCCTGGGCTGTACAAACATGGTATGACTCTCTTGGAGCAATAAACAAAATACAGGTAATGTACCATAATGCTGCATTATATACTATG...
Task1_train_12068
Given this context: Chromosome 7, gene CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; Congenital bilateral aplasia of vas deferens from CFTR mutation
CTCACAACTTTTAGGTTAATAGCCTTTGTCACCTTGCCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAG...
CTCACAACTTTTAGGTTAATAGCCTTTGTCACCTTGCCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAG...
Task1_train_12069
The gene CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1) on Chromosome 7 contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Bronchiectasis with or without elevated sweat chloride 1
CTCACAACTTTTAGGTTAATAGCCTTTGTCACCTTGCCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAG...
CTCACAACTTTTAGGTTAATAGCCTTTGTCACCTTGCCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAG...
Task1_train_12070
Located on Chromosome 7, this mutation impacts CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Hereditary pancreatitis
CTCACAACTTTTAGGTTAATAGCCTTTGTCACCTTGCCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAG...
CTCACAACTTTTAGGTTAATAGCCTTTGTCACCTTGCCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAG...
Task1_train_12071
This genomic variant is located on Chromosome 7, within the CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Cystic fibrosis
CTCACAACTTTTAGGTTAATAGCCTTTGTCACCTTGCCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAG...
CTCACAACTTTTAGGTTAATAGCCTTTGTCACCTTGCCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAG...
Task1_train_12072
A mutation in CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1), located on Chromosome 7, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Cystic fibrosis
CTCACAACTTTTAGGTTAATAGCCTTTGTCACCTTGCCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAG...
CTCACAACTTTTAGGTTAATAGCCTTTGTCACCTTGCCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAG...
Task1_train_12073
This mutation occurs in CFTR-AS1, CFTR (CFTR antisense RNA 1| CF transmembrane conductance regulator) on Chromosome 7. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Cystic fibrosis
CCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAGGATGTTTGAAGTAGTTTCTAACACAGAGATTATACT...
CCATATACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAGGATGTTTGAAGTAGTTTCTAACACAGAGATTATACT...
Task1_train_12074
The gene CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1) on Chromosome 7 contains a mutation. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.
Pathogenic; Cystic fibrosis
ACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAGGATGTTTGAAGTAGTTTCTAACACAGAGATTATACTCAATAA...
ACATCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAGGATGTTTGAAGTAGTTTCTAACACAGAGATTATACTCAATAA...
Task1_train_12075
This genomic variant is located on Chromosome 7, within the CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1) gene. Can you determine its pathogenicity and name any linked disease?
Pathogenic; Cystic fibrosis
TCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAGGATGTTTGAAGTAGTTTCTAACACAGAGATTATACTCAATAAATA...
TCTGATCCAGCCACTCACACCATTCCTGAGATATATTTTGTTCCTTTGTGCCTAAATCATTGTGCATGCAGATCCATCTTCCTGGAACACCTATAACCATTTCTTAGTCCTGTGAAATCCTACTTACATCCTTCATAGCCTAGCATGTATGTCATTTATTTGGTCAAGGGTGAGTTGGTTGTTCTCTTGAATGTACTGCCATATGACGTGGTGTGATTTCAATTGTAGCACCAAGCTCATTGCAATATTAATTCGTTTGTCATTCTCCCATGTAGGATGTTTGAAGTAGTTTCTAACACAGAGATTATACTCAATAAATA...
Task1_train_12076
The gene CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1) on Chromosome 7 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Cystic fibrosis
TTTAGGTCTTCTACATCTTCACTTATCTTTTTTCTACTTGCTTTGCCATTAACAGATAAAGTTGAATTAAAGGCTTCTACTACATACATTTCTCCCTGTTATTCCTTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTG...
TTTAGGTCTTCTACATCTTCACTTATCTTTTTTCTACTTGCTTTGCCATTAACAGATAAAGTTGAATTAAAGGCTTCTACTACATACATTTCTCCCTGTTATTCCTTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTG...
Task1_train_12077
Gene CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1), found on Chromosome 7, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Cystic fibrosis
ACTTATCTTTTTTCTACTTGCTTTGCCATTAACAGATAAAGTTGAATTAAAGGCTTCTACTACATACATTTCTCCCTGTTATTCCTTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTA...
ACTTATCTTTTTTCTACTTGCTTTGCCATTAACAGATAAAGTTGAATTAAAGGCTTCTACTACATACATTTCTCCCTGTTATTCCTTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTA...
Task1_train_12078
Mutation context: Chromosome 7, Gene CFTR-AS1, CFTR (CFTR antisense RNA 1| CF transmembrane conductance regulator). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Cystic fibrosis
GGCTTCTACTACATACATTTCTCCCTGTTATTCCTTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCT...
GGCTTCTACTACATACATTTCTCCCTGTTATTCCTTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCT...
Task1_train_12079
The variant affects gene CFTR-AS1, CFTR (CFTR antisense RNA 1| CF transmembrane conductance regulator), which is on Chromosome 7. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; CFTR-related disorder
GGCTTCTACTACATACATTTCTCCCTGTTATTCCTTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCT...
GGCTTCTACTACATACATTTCTCCCTGTTATTCCTTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCT...
Task1_train_12080
This variant affects gene CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1) located on Chromosome 7. Evaluate its biological effect and specify any disease association.
Pathogenic; Cystic fibrosis
TCTACTACATACATTTCTCCCTGTTATTCCTTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCTTAAT...
TCTACTACATACATTTCTCCCTGTTATTCCTTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCTTAAT...
Task1_train_12081
A genetic alteration is present in CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1) on Chromosome 7. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; Cystic fibrosis
TTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCTTAATAGATGGGTTAAGCCAACTGAAAAATAAAAC...
TTATAGGTTCTGTAATTTTTGCTTCAAGAATATTGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCTTAATAGATGGGTTAAGCCAACTGAAAAATAAAAC...
Task1_train_12082
A variant was discovered in gene CFTR-AS1, CFTR (CFTR antisense RNA 1| CF transmembrane conductance regulator), Chromosome 7. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Cystic fibrosis
TGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCTTAATAGATGGGTTAAGCCAACTGAAAAATAAAACTGACTTATATACTTTTATTTCAAGTATGTCCTC...
TGCTTTTTAAATTTAATATATAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCTTAATAGATGGGTTAAGCCAACTGAAAAATAAAACTGACTTATATACTTTTATTTCAAGTATGTCCTC...
Task1_train_12083
This alteration in CFTR, CFTR-AS1 (CF transmembrane conductance regulator| CFTR antisense RNA 1) on Chromosome 7 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Cystic fibrosis
TAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCTTAATAGATGGGTTAAGCCAACTGAAAAATAAAACTGACTTATATACTTTTATTTCAAGTATGTCCTCCACAAATATTTTTTGAATAG...
TAGATACTTATAATTACACTCTAGCATTATAAAGAGCCTTTTCTTTTTCATTGAATGTATTTGGGCCTGCATATGTCTAACATGAAAATTATAGTCCTTTTTTTGTTTCTTTGTTTGTATTTACAGTTTTAAGTTCCATTTTCAACCTTTATGCACTCTTTGCTTTAGGTGTGTCTCTTTTAGTTAGCATAAAGTTAGGTTTGTCTTTAATTTCACCTGAAGTCTTTTCCTCTTAATAGATGGGTTAAGCCAACTGAAAAATAAAACTGACTTATATACTTTTATTTCAAGTATGTCCTCCACAAATATTTTTTGAATAG...
Task1_train_12084
Consider a variant on Chromosome 7 in gene LOC111674475, CFTR (CFTR intron 11 enhancer| CF transmembrane conductance regulator). Determine its clinical classification and disease relevance.
Pathogenic; Cystic fibrosis
CTCCCTCACCCTCCTGAGTAGCTGGGGCTACAGGTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCA...
CTCCCTCACCCTCCTGAGTAGCTGGGGCTACAGGTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCA...
Task1_train_12085
A mutation found in CFTR, LOC111674475 (CF transmembrane conductance regulator| CFTR intron 11 enhancer) on Chromosome 7 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Cystic fibrosis
TCCCTCACCCTCCTGAGTAGCTGGGGCTACAGGTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCAC...
TCCCTCACCCTCCTGAGTAGCTGGGGCTACAGGTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCAC...
Task1_train_12086
This mutation is located in gene CFTR, LOC111674475 (CF transmembrane conductance regulator| CFTR intron 11 enhancer) on Chromosome 7. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Cystic fibrosis
CACCCTCCTGAGTAGCTGGGGCTACAGGTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCACTTGCA...
CACCCTCCTGAGTAGCTGGGGCTACAGGTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCACTTGCA...
Task1_train_12087
A genomic change on Chromosome 7 affects CFTR, LOC111674475 (CF transmembrane conductance regulator| CFTR intron 11 enhancer). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Cystic fibrosis
CTACAGGTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCACTTGCATGAACACCTCTAAATTACCTT...
CTACAGGTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCACTTGCATGAACACCTCTAAATTACCTT...
Task1_train_12088
This mutation is located in gene CFTR, LOC111674475 (CF transmembrane conductance regulator| CFTR intron 11 enhancer) on Chromosome 7. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Cystic fibrosis
ACAGGTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCACTTGCATGAACACCTCTAAATTACCTTAT...
ACAGGTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCACTTGCATGAACACCTCTAAATTACCTTAT...
Task1_train_12089
Consider a variant on Chromosome 7 in gene CFTR, LOC111674475 (CF transmembrane conductance regulator| CFTR intron 11 enhancer). Determine its clinical classification and disease relevance.
Pathogenic; Cystic fibrosis
GTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCACTTGCATGAACACCTCTAAATTACCTTATTACC...
GTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCACTTGCATGAACACCTCTAAATTACCTTATTACC...
Task1_train_12090
A variant found in Chromosome 7 affects LOC111674475, CFTR (CFTR intron 11 enhancer| CF transmembrane conductance regulator). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Cystic fibrosis
GTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCACTTGCATGAACACCTCTAAATTACCTTATTACC...
GTGCATGCTACCATGCCCAGCTAATTTAAAAGGAAAAAAATTGTGTAGAGATGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAACTTCCAATCTCAAGCATTTCTCCCACCCAGCATCCTGAAGTGCTGAGATTATAAGTGAGCCACTATGCCCAACCAGATTTAGTTTTTAAAAAGAGAATACGATTTGAAAAAGGAAAAATGTGAGGCAGGAGAGAAGAAATACACACACGAGCTGTTTTGTAATTGCTGTAAAACTGAAATCTTCAGCCTCACTAAAGGAGCACTTGCATGAACACCTCTAAATTACCTTATTACC...
Task1_train_12091
This sequence variant lies in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Cystic fibrosis
TTAAAATAAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGG...
TTAAAATAAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGG...
Task1_train_12092
An alteration has been detected in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Cystic fibrosis
TTAAAATAAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGG...
TTAAAATAAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGG...
Task1_train_12093
This is a variant in CFTR (CF transmembrane conductance regulator), located on Chromosome 7. Is this mutation a likely cause of disease or not?
Pathogenic; Cystic fibrosis
AAAATAAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAA...
AAAATAAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAA...
Task1_train_12094
A variant has been detected on Chromosome 7 in CFTR (CF transmembrane conductance regulator). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Hereditary pancreatitis
AAAATAAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAA...
AAAATAAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAA...
Task1_train_12095
The gene CFTR (CF transmembrane conductance regulator) is located on Chromosome 7, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Cystic fibrosis
AAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAAACTAA...
AAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAAACTAA...
Task1_train_12096
This alteration occurs within gene CFTR (CF transmembrane conductance regulator) located on Chromosome 7. Is it associated with a disease or is it a benign variant?
Pathogenic; Cystic fibrosis
AAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAAACTAA...
AAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAAACTAA...
Task1_train_12097
A variant found in Chromosome 7 affects CFTR (CF transmembrane conductance regulator). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Cystic fibrosis
AAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAAACTAA...
AAACAGGACAAATGCATTAACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAAACTAA...
Task1_train_12098
Given this variant in gene CFTR (CF transmembrane conductance regulator) on Chromosome 7, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Cystic fibrosis
AACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAAACTAACCCTAACTGAGCACCTGC...
AACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAAACTAACCCTAACTGAGCACCTGC...
Task1_train_12099
A sequence alteration has been identified in CFTR (CF transmembrane conductance regulator) on Chromosome 7. Is it disease-inducing or harmless?
Pathogenic; Cystic fibrosis
ACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAAACTAACCCTAACTGAGCACCTGCA...
ACATTGTTGGGGGAGGAGGTCCCTTAGTAGAAACACTCTTGGTCCAAGCATTTTAAAGCTGTCAAAGAGATGTAAATATAGATAATGTATGTCAAGGAGAGAGCTTTGTGGTTAAACTGTAACTTTCAGTTTAAACAATTATTGGTGACTCTGATGTCAAATGTTTCTCAAGCTTTATCTGAACAAAATTCTTCTCACTTTGTTGCCAAAGTCGTTAACAAGAAATCACATTGACTCATTGATGTTTTGGCTCCTTTCCCTTACTTTCTGTTGCTTTCCAAAAGCTGAGACAGGAAACTAACCCTAACTGAGCACCTGCA...