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versions of Visual Studio. In addition, each new version of Visual Studio does not integrate with an earlier version of MSDN. A compatible MSDN Library is released with each new version of Visual Studio and included on Visual Studio DVD. As newer versions of Visual Studio are released, newer editions of MSDN Library do... | is authored both by Microsoft and by the community at large. Recently, Microsoft has placed emphasis on incorporation of forums, blogs, library annotations and social bookmarking to make MSDN an open dialog with the developer community rather than a one-way service. The main website, and most of its constituent applica... |
B and Ella are possible abortifacients, able to interfere with a fertilized egg's implantation in the uterine wall. The labeling mandated by the U.S. Food and Drug Administration (FDA) for Plan B and Ella state that they may interfere with implantation, but according to a June 2012, The New York Times article, many sci... | taxpayer funding for abortions and passing a constitutional amendment which would restore protection of the right to life for unborn children, it also accepted the fact that many Americans, including fellow Republicans, were divided on the issue. Since about 1980, the Christian right has been associated with several in... |
went to a Catholic school for seven or eight years: St Joseph's Secondary School, just outside Leeds. He later said, "I used to be scared stiff of the nuns: their whole denial of womanhood—the black dresses and the shaving of the hair—was so horrible, so terrifying. [...] Of course, that's all been stopped. They're sip... | The Bible: In the Beginning... (1966), directed by John Huston. In 1966 at the Gaiety Theatre in Dublin he appeared in productions of Juno and the Paycock and Man and Superman. Sam Spiegel, producer of Lawrence of Arabia, reunited O'Toole with Omar Sharif in The Night of the Generals (1967), which was a box office disa... |
Sodium nitrate (NaNO3), a compound Chile saltpeter or nitratine, the mineral form Norwegian saltpeter or calcium nitrate | saltpetre) is the mineral form of potassium nitrate (KNO3), a compound It may also sometimes refer to: Sodium nitrate (NaNO3), a compound Chile saltpeter or nitratine, the mineral |
bull-shaped figure of a man emerge from his thigh, and then came to the realization that she herself had been the tree. Her father Cadmus, fearful of the prophetic dream, instructed Semele to make sacrifices to Zeus. Zeus came to Semele in her bed, adorned with various symbols of Dionysus. He transformed into a snake, ... | only with Hades, but also his father Zeus, and implied a particularly close identification with the sun-god Helios. When quoting this in his Hymn to King Helios, Emperor Julian substituted Dionysus' name with that of Serapis, whose Egyptian counterpart Osiris was also identified with Dionysus. Worship from the Middle A... |
in making salads of beans (such as three bean salad), noodle or pasta salads and antipasti, and forms of potato salad. Salad dressings can be drizzled over a salad, added and tossed with the ingredients, offered on the side, or served as a dip, as with crudités or chicken wings. Types In Western culture, there are two ... | dip, as with crudités or chicken wings. Types In Western culture, there are two basic types of salad dressing: Vinaigrettes based on a mixture (emulsion) of olive or salad oil and vinegar, and variously flavored with herbs, spices, salt, pepper, sugar, and other ingredients such as poppy seeds or ground Parmesan cheese... |
eleventh round knock out. In 1976, he defeated future Light Welterweight Champion Saoul Mamby. Overall, Durán made twelve successful defenses of his title (eleven coming by knockout) and amassed a record of 62–1, his last defense coming in 1978 when Durán fought a third bout with De Jesus in a unification match wherein... | warm homecoming from the place where Leonard had won Olympic gold, Leonard only got a mixed reception in Montreal, while Durán was incredibly popular with the crowd, with Leonard later admitting that Durán's popularity in Canada "threw me for a loop". On June 20, 1980, Durán captured the WBC Welterweight title by defea... |
when the speculation collapsed. The boom-and-bust cycle of early-industrial Britain was still in effect, and the boom that had created the conditions for Railway Mania began to cool and then a decline set in. The number of new railway companies fell away to almost nothing in the late 1840s and early 1850s, with the onl... | the nascent Midland began to buy up strategic failed lines to expand their network. These lines could be purchased at a fraction of their real value as given a choice between a below-value offer for their shares or the total loss of their investment, shareholders naturally chose the former. Many middle class families o... |
a drum to control an electronic device Trigger (guitar), the Martin N-20 guitar played by Willie Nelson Trigger (trombone), a switch that enables a trombonist to switch from one set of tubing to another Trigger pad, a device used in electronic percussion Songs "Trigger" (song), a 2019 song by Major Lazer and Khalid "Tr... | actuates the firing of firearms Database trigger, procedural code that is automatically executed in response to certain events Dead man's trigger, a safety device that activates safeguards if the operator is incapacitated Flip-flop (electronics), called a trigger circuit by IBM Image trigger, a device used in high spee... |
as the only son of Peter II of Aragon and Marie of Montpellier. As a child, James was made a pawn in the power politics of Provence, where his father was engaged in struggles helping the Cathar heretics of Albi against the Albigensian Crusaders led by Simon IV de Montfort, Earl of Leicester, who were trying to extermin... | decided to turn south. His great part in the Reconquista was similar in Mediterranean Spain to that of his contemporary Ferdinand III of Castile in Andalusia. One of the main reasons for this formal renunciation of most of the once Catalan territories in Languedoc and Occitania and any expansion into them is the fact t... |
Adonai ("the Lord") or HaShem ("the name") when reading. In addition, illogical statements, principles, reasons and arguments may be considered intrinsically ineffable along with impossibilities, contradictions and paradoxes. Terminology describing the nature of experience cannot be conveyed properly in dualistic symbo... | taboo or incomprehensible term. This property is commonly associated with philosophy, aspects of existence, and similar concepts that are inherently "too great", complex or abstract to be communicated adequately. An example is the name of God in Judaism, written as YHWH but substituted with Adonai ("the Lord") or HaShe... |
he sees, and chooses to keep silent. Five decades after their arrival, the Overlords finally reveal their appearance: large bipeds that resemble the traditional Christian folk images of demons, with cloven hooves, leathery wings, horns, and barbed tails. The Golden Age Humankind enters a golden age of prosperity at the... | for the Retro Hugo Award for Best Novel in 2004. Several attempts to adapt the novel into a film or miniseries have been made with varying levels of success. Director Stanley Kubrick expressed interest in the 1960s, but collaborated with Clarke on 2001: A Space Odyssey (1968) instead. The novel's theme of transcendent ... |
crystallization. Explaining and providing a model for this phenomenon has been a task taken on by more recent research. Désiré Gernez contributed to this research by discovering that nuclei must be of the same salt that is being crystallized in order to promote crystallization. Occurrence and examples Solid precipitate... | weeks. Supersaturation may be encountered when attempting to crystallize a protein. Gaseous solute, liquid solvent The solubility of a gas in a liquid increases with increasing gas pressure. When the external pressure is reduced, the excess gas comes out of solution. Fizzy drinks are made by subjecting the liquid to ca... |
Byzantine Empire under the Palaiologos dynasty, of Venice's relations with the Byzantine emperors, when that part of the dogal titelature was substituted by 'and lord of the lands and islands subject to his dogate' () or similar formulations. In a similar manner, the disputes between Venice and Hungary over Dalmatia an... | recipient for life but were not inherent in the office (, ), but the title belonged to the office (, ). Thus, into the eleventh century the Venetian doges held titles typical of Byzantine rulers in outlying regions, such as Sardinia. As late as 1202, the Doge Enrico Dandolo was styled , a title granted to him by Alexio... |
by Papandreist officers of Hellenic National Intelligence Service (the Greek security and intelligence service), and named Kostas Tsimas (the head of EYP) and Colonel Alexakis as two of the supposed controllers of 17N. However, after 17N members were arrested, the only connection between the terrorist organization and ... | of evidence. The convicted members were sentenced on 17 December 2003. All those convicted defendants appealed. On 3 May 2007, the convictions were upheld. Prison In early January 2014, Christodoulos Xyros, one of the imprisoned leaders of the organization, escaped from prison. On 6 January, he failed to report to the ... |
sophistication to American musical comedy." The theatre writer Gerald Bordman calls Wodehouse "the most observant, literate, and witty lyricist of his day". The composer Richard Rodgers wrote, "Before Larry Hart, only P.G. Wodehouse had made any real assault on the intelligence of the song-listening public." 1920s In t... | works brought a new level of intimacy, cohesion, and sophistication to American musical comedy." The theatre writer Gerald Bordman calls Wodehouse "the most observant, literate, and witty lyricist of his day". The composer Richard Rodgers wrote, "Before Larry Hart, only P.G. Wodehouse had made any real assault on the i... |
is characterised by the introduction of electric guitars and basses, with more and more rock elements being added to the slow, keyboard-based music of the earliest album. With Stille, Lacrimosa releases an album that might easily be classified as 'metal', a style which they'll keep using for their own purposes from the... | influence from electronic and industrial music, as is especially obvious in the song "Ein Hauch von Menschlichkeit" ("A Touch of Humanity"). Overall, this album is more personal, more 'classical' and more quiet than those that came before it. Thematically, there is less change as Lacrimosa continues to explore love and... |
then, perpendicular to that, by chromatography in the other. The different peptide fragments of insulin, detected with ninhydrin, moved to different positions on the paper, creating a distinct pattern that Sanger called "fingerprints". The peptide from the N-terminus could be recognised by the yellow colour imparted by... | the 2009 Nobel Prize in Physiology or Medicine with Carol W. Greider and Jack W. Szostak for her work on telomeres and the action of telomerase. Awards and honours , Sanger is the only person to have been awarded the Nobel Prize in Chemistry twice, and one of only four two-time Nobel laureates: The other three were Mar... |
his uncle Claude Bossuet d'Aiseray, a renowned scholar. At the Collège des Godrans, he gained a reputation for hard work: fellow students nicknamed him Bos suetus aratro, an "ox accustomed to the plough". His father's influence at Metz allowed him to obtain for the young Bossuet a canonry in the cathedral of Metz when ... | 1669, Bossuet was gazetted bishop of Condom in Gascony, without being obliged to reside there. He was consecrated bishop on September 21, 1670, but he resigned the see when he was elected to the Académie française in 1671. On 18 September 1670 he was appointed tutor to the nine-year-old Dauphin, eldest child of Louis X... |
depending on species. They lay one or (usually) two white eggs at a time, and both parents care for the young, which leave the nest after 25–32 days. Unfledged baby doves and pigeons are called squabs and are generally able to fly by 5 weeks of age. These fledglings, with their immature squeaking voices, are called squ... | pigeons have strong wing muscles (wing muscles comprise 31–44% of their body weight) and are among the strongest fliers of all birds. In a series of experiments in 1975 by Dr.Mark B. Friedman, using doves, their characteristic head bobbing was shown to be due to their natural desire to keep their vision constant. It wa... |
Sciences (in his time the Academy of Sciences of the USSR) from its founding in 1957 to 1975. The foundation of the Siberia's "Academic Town" Akademgorodok (now a district of Novosibirsk) remains his most widely known achievement. Six months after the decision to found the Siberian Division of the USSR Academy of Scien... | was one of his students. In 1939 Alexander A. Bogomolets, the president of the Ukrainian Academy of Sciences, asked Lavrentev become director of the Institute of Mathematics at Kyiv One of Lavrentiev's scientific interests was the physics of explosive processes, in which he had become involved when doing defense work d... |
John Kenneth Galbraith (professor, United States): for outstanding achievements in economic and social sciences. 1994 Nikolai Konstantinovich Kochetkov: for outstanding achievements in the chemistry of carbohydrates and organic synthesis. James D. Watson (professor, United States): for outstanding achievements in molec... | of the German Democratic Republic): for outstanding achievements in the physics of plasma and applied physics. 1973 Aleksandr Pavlovich Vinogradov: for outstanding achievements in geochemistry. Vladimír Zoubek (full member of the Czechoslovak Academy of Sciences): for outstanding achievements in geology. 1974 Aleksandr... |
the Royal Swedish Academy of Sciences. In 1764, he was elected Foreign Member of the Academy of Sciences of the Institute of Bologna In 1764, Lomonosov was appointed to the position of the State Councillor which was of Rank V in the Russian Empire's Table of Ranks. He died on 4 April (o.s.), 1765 in Saint Petersburg. H... | easier. In 1764, he organized an expedition (led by Admiral Vasili Chichagov) to find the Northeast Passage between the Atlantic and Pacific oceans by sailing along the northern coast of Siberia. Mosaicist Lomonosov was proud to restore the ancient art of mosaics. In 1754, in his letter to Leonhard Euler, he wrote that... |
That year he met (possibly through his brother Alec) and fell in love with Evelyn Gardner, the daughter of Lord and Lady Burghclere. "He-Evelyn" and "She-Evelyn" In December 1927, Waugh and Evelyn Gardner became engaged, despite the opposition of Lady Burghclere, who felt that Waugh lacked moral fibre and kept unsuitab... | of the 1920s, was published on 19 January 1930 and was Waugh's first major commercial success. Despite its quasi-biblical title, the book is dark, bitter, "a manifesto of disillusionment", according to biographer Martin Stannard. As a best-selling author Waugh could now command larger fees for his journalism. Amid regu... |
the beginnings of Modernism in the English-speaking world. In London, the Contemporary Art Society was founded in 1910 by the critic Roger Fry and others, as a private society for buying works of art to place in public museums. A number of other institutions using the term were founded in the 1930s, such as in 1938 the... | whole is distinguished by the very lack of a uniform, organising principle, ideology, or "-ism". Contemporary art is part of a cultural dialogue that concerns larger contextual frameworks such as personal and cultural identity, family, community, and nationality. In vernacular English, modern and contemporary are synon... |
"Widecombe Fair") "D'ye Ken Jim Pubes"(to the tune of "D'ye Ken John Peel") "Green Grow My Nadgers Oh!"(to the tune of "Green Grow the Rushes, O") "The Ballad of the Woggler's Moulie"(to the tune of "Oh My Darling, Clementine") "The Taddle Gropers' Dance"(to the tune of "Here We Go Round the Mulberry Bush") "What Shall... | Took and Marty Feldman, who wrote the majority of the songs' lyrics, based upon traditional folk songs. Some were existing words used in a suggestive context, such as 'artefacts' (often used in an archaeological context for things such as grave goods) and 'nadgers', which had already appeared in The Goon Show. On 3 Jul... |
of which came from domestic markets. Commercially, Streep fared better with a role in The Devil Wears Prada (also 2006), a loose screen adaptation of Lauren Weisberger's 2003 novel of the same name. Streep portrayed the powerful and demanding Miranda Priestly, fashion magazine editor (and boss of a recent college gradu... | degree from the college in 1981. Career 1970s: Early work and breakthrough One of Streep's first professional jobs in 1975 was at the Eugene O'Neill Theater Center's National Playwrights Conference, during which she acted in five plays over six weeks. She moved to New York City in 1975, and was cast by Joseph Papp in a... |
of the world around them, and of the constructs within which they live. Thus, a society that is, for example, completely secular and one which believes every eventuality to be subject to metaphysical influence will have very different consensus realities, and many of their beliefs on broad issues such as science, slave... | subject to metaphysical influence will have very different consensus realities, and many of their beliefs on broad issues such as science, slavery, and human sacrifice may differ in direct consequence because of the differences in the perceived nature of the world they live in. In science and philosophy Idealists Some ... |
ultimate dynastic achievements. He was born in Munich to Ferdinand Maria, Elector of Bavaria and Princess Henriette Adelaide of Savoy (d.1676). His maternal grandparents were Victor Amadeus I of Savoy and Christine of France, daughter of King Henri IV. War against the Ottoman Empire Maximilian inherited the elector's m... | for Maximilian Emanuel's ambition was offered by his marriage on 12 January 1694 to Theresa Kunegunda Sobieska, the death of whose father, the elected King of Poland John III Sobieski, two years later, offered a potential avenue of influence in Polish affairs. However, he concentrated his interests in Western Europe, m... |
bacon and ham exports went to Britain, where Danish bacon was preferred to domestic bacon. Danish bacon was produced in a state-supported factory system with more standardised quality and was extensively advertised. In the Second World War Danish bacon was not available, and the American alternative, said to be fat and... | cuts. Bacon is also sold and served as joints, usually boiled, broiled or roast, or in thicker slices called chops or steaks. These are usually eaten as part of other meals. Bacon may be cured in several ways, and may be smoked or unsmoked; unsmoked bacon is known as "green bacon". Fried or grilled bacon rashers are in... |
the reciprocal of the failure rate of the system The units used are typically hours or lifecycles. This critical relationship between a system's MTBF and its failure rate allows a simple conversion/calculation when one of the two quantities is known and an exponential distribution (constant failure rate, i.e., no syste... | normal system operation. MTBF can be calculated as the arithmetic mean (average) time between failures of a system. The term is used for repairable systems, while mean time to failure (MTTF) denotes the expected time to failure for a non-repairable system. The definition of MTBF depends on the definition of what is con... |
national park. Ashburton has five pubs within the centre of town and five restaurants/cafés. The town is also part of the electoral ward named Ashburton and Buckfastleigh, the population of which at the 2011 census was 7,718. History The town's name derives from the Old English æsc-burna-tun meaning 'farm/settlement wi... | 7 September 1962. Ashburton used to be famous for a beverage known as Ashburton Pop, possibly a type of champagne, the recipe of which was lost with the brewer in 1765. Ashburton Carnival is one of the oldest, possibly the oldest, surviving in Devon. Written records date it back to 1891, but it is believed to have been... |
year, he narrated the nature documentaries Spectacled Bears: Shadow of the Forest for the BBC Natural World series. In the 2009 television series Last Chance to See, Fry and zoologist Mark Carwardine sought out endangered species, some of which had been featured in Douglas Adams' and Carwardine's 1990 book and radio se... | British celebrities Sir Roger Moore, Ewan McGregor, Dame Joan Collins, Joanna Lumley, Michael Caine, David Walliams, Charlotte Rampling, Paul McKenna and Michael Ball. In 2015, Fry made a live audio recording of the winning short story of the annual RA & Pin Drop Short Story Award, Ms. Featherstone and the Beast by Bet... |
Canada's official representatives at the memorial service. Marriage and family Turner was married on May 11, 1963, to Geills McCrae Kilgour (b. 1937) who was then a systems engineer with IBM, and the great niece of Canadian Army doctor John McCrae, the author of what is probably the best-known First World War poem, "In... | say Litt, included strengthening the rights of individual defendants on trial, greater efficiency in the justice system, creation of the influential Law Reform Commission, selecting highly professional judges, and bringing a policy perspective to the Justice Department. He led the government's position in the highly co... |
conflicts of interest and embarrassing scandals. Many Tories expected patronage appointments due to the long time out of government. Indeed, Mulroney made a number of unscripted gaffes regarding patronage, including the reference to Ambassador Bryce Mackasey as "there's no whore like an old whore". Domestic events Mulr... | 80% of Canadians were opposed to the tax. Mulroney had to use Section 26 (the Deadlock Clause), a little known Constitutional provision, allowing him in an emergency situation to ask the Queen to appoint 8 new Senators. Although the government argued that the tax was not a tax increase, but a tax shift, the highly visi... |
caucus, but this still left the Tories five seats short of a majority. Clark however decided that he would govern as if he had a majority, and refused to grant the small Socred official party status, form a coalition, or co-operate with the party in any way. Clark was unable to accomplish much in office because of the ... | party leader. Prime Minister of Canada, 1979–1980 On June 4, 1979, the day before his 40th birthday, Clark was sworn in as Canada's youngest prime minister, steering the first Tory government since the defeat of John Diefenbaker in the 1963 election. With a minority government in the House of Commons, Clark had to rely... |
£8.3 million was used to fund the establishment of the new Sinclair Vehicles company. Sinclair recruited Barrie Wills, a veteran former employee of the DeLorean Motor Company, to lead Sinclair Vehicles as its managing director. Although Wills initially expressed scepticism about the viability of an electric vehicle – h... | A heat-sensitive resistor inside the motor warns the driver if the vehicle is beginning to overheat and disconnects the motor after a short time, and a third line of defence is provided by a metallic strip mounted on the motor. If an excessive temperature is reached the strip distorts and the power is disconnected. Alt... |
to disrobe to show all their beauty). Still, Paris could not decide, as all three were ideally beautiful, so the goddesses attempted to bribe him to choose among them. Hera offered ownership of all of Europe and Asia. Athena offered skill in battle, wisdom and the abilities of the greatest warriors. Aphrodite offered t... | he does not follow the code of honor shared by the other heroes. Early in the epic, Paris and Menelaus duel in an attempt to end the war without further bloodshed. Menelaus easily defeats Paris, though Aphrodite spirits him away before Menelaus can finish the duel. Paris is returned to his bedchambers, where Aphrodite ... |
Marmaduke Huby (1495–1526). At Abbot Huby's death he was succeeded by William Thirsk, who was accused by the royal commissioners of immorality and inadequacy and was dismissed as abbot. He was replaced by Marmaduke Bradley, a monk of the abbey who had reported Thirsk's supposed offences, testified against him and offer... | from rents. They were the gifts of the founder and subsequent patrons, but some were purchased from cash revenues. At the outset, the Cistercian order rejected gifts of mills and rents, churches with tithes and feudal manors as they did not accord with their belief in monastic purity, because they involved contact with... |
(which did not generally exist yet). The 6507 and 6502 chips use the same underlying silicon layers, and differ only in the final metallisation layer. This ties the interrupt lines to their inactive level so they are not vulnerable to generating spurious interrupts from noise. The first three digits of the chip identif... | 6502 and 6507 shows this difference. The 6507 was only widely used in two applications: the best-selling Atari 2600 video game console and Atari 8-bit family peripherals including the 850 Serial & Parallel Interface, and the 810 and 1050 disk drives. In the 2600, the system was further limited by the design of the ROM ... |
walking up a path. Sometimes there was a single flower on the planet." His characters were frequently seen chasing butterflies; when asked why they did so, Saint-Exupéry, who thought of the figures as his alter-egos, replied that they were actually pursuing a "realistic ideal". Saint-Exupéry eventually settled on the i... | to close friends and colleagues; others were even recovered as crumpled balls from the floors in the cockpits he flew. Two or three original Little Prince drawings were reported in the collections of New York artist, sculptor and experimental filmmaker Joseph Cornell. One rare original Little Prince watercolour would b... |
Middleton was writing for the Admiral's Men. Unlike Shakespeare, Middleton remained a free agent, able to write for whichever company hired him. His early dramatic career was marked by controversy. His friendship with Thomas Dekker brought him into conflict with Ben Jonson and George Chapman in the War of the Theatres.... | his satirical fury is tempered and broadened, includes three of his acknowledged masterpieces. A Chaste Maid in Cheapside, produced by the Lady Elizabeth's Men, skilfully combines London life with an expansive view of the power of love to effect reconciliation. The Changeling, a late tragedy, returns Middleton to an It... |
release. TI ultimately ended up shipping early machines with a custom television as the testing process dragged on. To meet the off-the-shelf requirement while including internal TV circuitry, the new machines needed to be heavily shielded. Both were built around very strong cast aluminum shields forming a partial Fara... | new machines, saw the Atari work during a visit to Grass Valley. He realized the Commodore design would not be competitive but he was under a strict non-disclosure agreement with Atari, and was unable to tell anyone at Commodore to give up on their own design. Peddle later commented that "the thing that Jay did, just k... |
move all of their pieces to their opponent's starting squares wins. See also Gonu Bibliography External links Five Field Kono applet Five Field Kono at Zillions of Games Android version of Five Field Kono (supports games with bots and via | into the starting locations of their opponent's pieces. Rules The players take turns moving one of their pieces one square diagonally. The first player to move all of their pieces to their opponent's starting squares wins. See also Gonu Bibliography External links Five Field Kono applet Five Field |
arrives and announces that he has been busy, and they will drink and then go to Entmoot. Entmoot, he explains to Pippin, is not a place but a gathering of Ents. Treebeard carries them to the place where the Ents meet. This gathering lasts three days. The Entmoot ends with all the Ents shouting, and then singing a march... | period of Morgoth's rule before the arising of the Moon and Sun, never lifted and the trees are older than he. Treebeard is described in some detail: After meeting Merry and Pippin, Treebeard learns that they think that Gandalf is dead, though apparently he knows otherwise. He then takes them to a place that he says mi... |
wins by forming a mill, that is, three of their own pieces in a row. Rules Each player has three pieces. The winner is the first player to align their three pieces on a line drawn on the board. There are 3 horizontal lines, 3 vertical lines and 2 diagonal lines. The board is empty to begin the game, and players take tu... | related to six men's morris and nine men's morris. A player wins by forming a mill, that is, three of their own pieces in a row. Rules Each player has three pieces. The winner is the first player to align their three pieces on a line drawn on the board. There are 3 horizontal lines, 3 vertical lines and 2 diagonal line... |
Salka Viertel; although reluctant to make the movie, MGM relented at Garbo's insistence. For her leading man, MGM suggested Charles Boyer or Laurence Olivier, but Garbo rejected both, preferring her former co-star and lover John Gilbert. The studio balked at the idea of casting Gilbert, fearing his declining career wou... | to prevent extras and technicians from watching her. When asked about these eccentric requirements, she said: "If I am by myself, my face will do things I cannot do with it otherwise." Despite her status as a star of silent films, the studio feared that her Swedish accent might impair her work in sound, and delayed the... |
was reported to have died of typhus in the work camp; however, Tramiel believed he was killed by an injection of gasoline. Tramiel was rescued from the labor camp in April 1945 by the 84th Infantry Division of the U.S. Army. On November 10, 1947, Tramiel immigrated to the United States. He soon joined the U.S. Army, wh... | which allowed Commodore to purchase MOS Technology, Inc. an IC design and semiconductor manufacturer, a company which had also supplied Commodore with calculator ICs. When their lead designer, Chuck Peddle, told Tramiel that calculators were a dead end and computers were the future, Tramiel told him to build one to pro... |
the outbreak of the French Revolution (1789–1799). Jussieu adhered to the revolutionary principles and was appointed to a position in the municipal government of Paris, where he had the task of managing all the hospitals. With the overthrow of the monarchy, the Jardin du Roi was renamed the Jardin des plantes, and Juss... | botany Demonstrator and deputy to L. G. Le Monnier, professor of botany there in 1770. Le Monnier had succeeded Antoine-Laurent's uncle Antoine in 1759. Lectures by eminent botanists, including the Jusssieu dynasty were popular there, especially among pharmacists. His lecture on the classification of Ranunculaceae in 1... |
the contest. He thus promised to solve the problem, if Tyndareus in turn would support him in his courting of Penelope, the daughter of Icarius. Tyndareus readily agreed, and Odysseus proposed that, before the decision was made, all the suitors should swear a most solemn oath to defend the chosen husband against whoeve... | from his tragedy Doctor Faustus (1604) are frequently cited: "Was this the face that launched a thousand ships / And burnt the topless towers of Ilium?" Etymology The etymology of Helen's name continues to be a problem for scholars. Georg Curtius related Helen () to the moon (Selene; ). Émile Boisacq considered Ἑλένη t... |
for example taking public names from the cultures they lived within, whilst keeping their "true-names" and true language a secret. Tolkien also invented the Cirth runes, in the fiction said to have been invented by Elves and later adopted by the Dwarves. Tolkien further underlined the diaspora of the Dwarves with the l... | the arising of the Children of Ilúvatar, created the seven Fathers of the Dwarves in secret, intending them to be his children to whom he could teach his crafts. He also taught them Khuzdul, a language he had devised for them. Ilúvatar, creator of Arda, was aware of the Dwarves' creation and sanctified them. Aulë seale... |
in a jar. Groups of children were given either a high or low "base" number (anchor). Children estimated the number of jellybeans to be closer to the anchor number that they were given. Availability heuristic — A mental shortcut that occurs when people make judgements about the probability of events by the ease with whi... | percent of participants, choosing from two options, chose that it was more likely for Linda to be a feminist and a bank teller than only a bank teller. The likelihood of two events cannot be greater than that of either of the two events individually. For this reason, the representativeness heuristic is exemplary of the... |
of highways in South Australia List of highways in Western Australia List of highways in Queensland List of highways in the Northern Territory List of highways in Tasmania Bangladesh List of roads in Bangladesh Belgium List of motorways in Belgium Bolivia Yungas Road Botswana Brazil List of highways in Brazil Rodovia P... | Australia For state listings see: Highways in New South Wales List of highways in Victoria List of highways in South Australia List of highways in Western Australia List of highways in Queensland List of highways in the Northern Territory List of highways in Tasmania Bangladesh List of roads in Bangladesh Belgium List ... |
shrouding them both in the impenetrable darkness she produced. Melkor had promised Ungoliant to yield anything she wished in return for her aid, but betrayed this promise by withholding the Silmarils, and summoned the Balrogs to repel her. Ungoliant fled to the Ered Gorgoroth in Beleriand. At some point she gave birth ... | spirit of night, named Móru, who aided Melkor in his attack upon the Two Trees of Valinor, draining them of their sap after Melkor had injured them. She also consumed the reserves of light from the wells of Varda. Afterward the light of the trees persisted only within the Silmarils of Fëanor. Ungoliant helped Melkor ev... |
of their ancestors Lúthien and Beren in the First Age in Beleriand, was to make Aragorn's line exceptionally long-lived among Men, and as the royal family intermarried with other people of Gondor, to maintain or extend the lifespan of the entire race. Fading The overall feeling in The Lord of the Rings, however, despit... | from the enslaved peoples such as Orcs. Tolkien uses the Men of Middle-earth, interacting with immortal Elves, to explore a variety of themes in The Lord of the Rings, especially death and immortality. This appears throughout, but is the central theme of an appendix, "The Tale of Aragorn and Arwen". Where the Hobbits s... |
now used only in Illinois and Minnesota. The National Route followed the following segments: Venice to Port Allen, Louisiana on the west bank Huey P. Long Bridge Baton Rouge, Louisiana to Greenville, Mississippi on the east bank Benjamin G. Humphreys Bridge (replaced by the Greenville Bridge in 2010) Lake Village to We... | north to follow I-110 and US 61 into Mississippi. In January 1811, there was a rebellion of several hundred enslaved and free black people referred to as the 1811 German Coast uprising, beginning in St. John the Baptist Parish and continuing on a route through lower Louisiana toward New Orleans. A Louisiana militia cou... |
Middle-earth, the Tolkien scholar Tom Shippey suggested that Goldberry is similar to the many named water spirits of traditional English folklore such as Jenny Greenteeth or Peg Powler of the River Tees, though she is noticeably gentler figure than they are. The scholar Ann McCauley believed that she is likely a water ... | scholars. On her possible origins, scholars have compared her with a character in George MacDonald's 1867 fairy tale The Golden Key, and with the eponymous character in the late-medieval lyric poem The Maid of the Moor. Her characterisation has been described as a mixture of the domestic and the supernatural, connected... |
Arwen, an appendix to the main story, relates that Aragorn and Arwen had a son, Eldarion, and at least two unnamed daughters. One year after Aragorn's death, Arwen dies at the age of 2,901. Background Through her father, Elrond, Arwen was the granddaughter of Eärendil the Mariner (the second of the Half-elven), great-g... | and Gondor before Elrond will allow her to marry him. The Tale of Aragorn and Arwen, an appendix to the main story, relates that Aragorn and Arwen had a son, Eldarion, and at least two unnamed daughters. One year after Aragorn's death, Arwen dies at the age of 2,901. Background Through her father, Elrond, Arwen was the... |
Helix DNA platform. Helix DNA Client is a software package for multi-platform multi-format media playback. Helix Player is a media player that runs on Linux, Solaris, Symbian and FreeBSD and uses the Helix DNA Client. The Helix DNA Producer application aids in the production of media files, and Helix DNA Server can str... | codecs requires binary components distributed under the Helix DNA Technology Binary Research Use License. Helix DNA Client Helix DNA Client powers many digital media applications, including RealPlayer for MS Windows, Mac OS and Linux (since version 10), RealPlayer Mobile, and Helix Player. It is used on Nokia, Motorola... |
the Rohirrim are shown as being at a lower level of enlightenment. The names and many details of Rohirric culture are derived from Germanic cultures, particularly that of the Anglo-Saxons and their Old English language, towards which Tolkien felt a strong affinity. Anglo-Saxon England was defeated by the cavalry of the... | common; Tolkien once also used "Rohanese". Like many languages of Men, it is akin to Adûnaic, the language of Númenóreans, and therefore to the Westron or Common Speech. The Rohirrim called their homeland the Riddermark, a modernization by Tolkien of Old English Riddena-mearc, meaning, according to the Index to The Lor... |
called a distinct element method, is any of a family of numerical methods for computing the motion and effect of a large number of small particles. Though DEM is very closely related to molecular dynamics, the method is generally distinguished by its inclusion of rotational degrees-of-freedom as well as stateful contac... | rock masses Typical industries using DEM are: Agriculture and food handling Chemical Detergents Oil and gas Mining Mineral processing Pharmaceutical industry Powder metallurgy Outline of the method A DEM-simulation is started by first generating a model, which results in spatially orienting all particles and assigning ... |
so that the bankruptcy will go smoothly, and whether the debtor's assets will be safe if they file. With expanded requirements of the BAPCPA bankruptcy act of 2005, filing a personal chapter 7 bankruptcy is complicated. Many attorneys that used to practice bankruptcy in addition to their other fields, have stopped doin... | corporation or partnership does not receive a bankruptcy discharge, whereas an individual may (see ). Once all assets of the corporate or partnership debtor have been fully administered, the case is closed. The debts of the corporation or partnership theoretically continue to exist until applicable statutory periods of... |
by Native Americans long before Europeans arrived. Some of these important native trails had been used long enough that they were two feet below the surrounding woodland. Following a trail known as the Pequot Path, the Upper Post Road was first laid out on January 1, 1673. Used by post riders to deliver the mail, it wa... | southward, the modern U.S. 17 has many segments that follow the old King's Highway. Mail delivery in the Northeast Herman Moll's 1729 "Post Map" described the route: Boston Post Road The Boston Post Road was a system of mail-delivery routes between New York City and Boston that evolved into the first major highways in ... |
a group of super-powered anti-heroes in DC Comics Music Elite (album), an album by Within the Ruins "Elite" (song), a song by Deftones from White Pony Elite (record producer) or Anthony Parrino, producer Tyshane or Elite, producer Products Beretta Elite II, an air pistol Elite Stratocaster, an electric guitar model Eur... | Elite SC, a football club in the Cayman Islands The Elite (professional wrestling), professional wrestling trio, later expanding into a stable Elitedivisionen, the highest-level league competition for women's football clubs in Denmark Television Élite (TV series), a Netflix TV series The Elite (audio drama), an audio d... |
Stephen Thomas Erlewine said the album "proves Eminem is the gold standard in pop music in 2002, delivering stylish, catchy, dense, funny, political music that rarely panders". Critic Robert Christgau wrote: "I think it represents an articulate, coherent, formally appropriate response to Eminem's changing position and ... | soundtrack of the film and his album. The album also saw Eminem take a substantially more predominant production role; most of it was self-produced, with his longtime collaborator Jeff Bass co-producing several tracks (mainly the songs which eventually, became the released singles). Dr. Dre, in addition to being the al... |
be close to the physical ideal for its breed standard at a cat show. Not all pedigreed cats are show cats, many are just pets but the ones with the best conformation and personality are often shown in associations such as the CFA and TICA in the US, the GCCF in the UK or the FiFe in the rest of Europe. Uncommonly, a pr... | just pets but the ones with the best conformation and personality are often shown in associations such as the CFA and TICA in the US, the GCCF in the UK or the FiFe in the rest of Europe. Uncommonly, a prize-winning pedigreed show cat can be worth thousands of dollars but most are loved pets. In order to compare exampl... |
bullpen had not suffered injuries. During the 2004 regular season Keith Foulke was used primarily as a closer in the conventional model; however, Foulke's usage in the 2004 postseason was along the lines of a relief ace with multiple inning appearances at pivotal times of the game. Houston Astros manager Phil Garner al... | pitcher's win-loss record. Many of his statistical innovations are arguably less important than the underlying ideas. When he introduced the notion of secondary average, it was as a vehicle for the then-counterintuitive concept that batting average represents only a fraction of a player's offensive contribution. (The r... |
For several weeks, Griffey's right leg was in a sling that kept it at a 90-degree angle, and he was not able to move the leg until late October. After an intense rehabilitation period, he returned for the 2005 season. In April, he hit .244 with one homer (on April 30) and nine RBIs. 2005–2006 Starting May 1, the 2005 s... | Reggie Jackson for tenth on the all-time home run list. Griffey's injuries continued in the 2006 off-season. While on holiday in the Bahamas with his family, he broke his wrist. Griffey said his hand felt fine and he expected to be ready to go for 2007 spring training. 2007 At the beginning of the 2007 Major League Bas... |
the original alignment of U.S. Route 1 in eastern Connecticut, Rhode Island, and Massachusetts. Connecticut Greenwich Stamford Norwalk Darien The road is Darien's main thoroughfare. Most businesses as well as both Metro-North stations, Darien and Noroton Heights. Westport Fairfield Bridgeport The road marked the northe... | years of Connecticut's history, East Hartford was privately owned. What remains of the route is the path of Interstate 84 / Route 6, which connects to Manchester's Middle Turnpike East. Manchester Since Manchester was a part of Hartford until 1783, the area was made up of settlements and present-day boroughs. The post ... |
and helmet and be accompanied by an appropriate adult. As pilots progress, they may challenge themselves by kiting over and around obstacles, in strong or turbulent wind, and on greater slopes. Flying Launching As with all aircraft, launching and landing are done into wind. The wing is placed into an airstream, either ... | on a winch has quite different characteristics from free flying. There are two major ways to tow: pay-in and pay-out towing. Pay-in towing involves a stationary winch that winds in the towline and thereby pulls the pilot in the air. The distance between winch and pilot at the start is around 500 metres or more. Pay-out... |
and adjacent roadways. A new international airport terminal was completed in 2013 as part of the federal government's Stimulus Reconstruction Program. Geological history The geology of Duluth demonstrates the Midcontinent Rift, formed as the North American continent began to split apart about 1.1 billion years ago. As ... | the federal government's Stimulus Reconstruction Program. Geological history The geology of Duluth demonstrates the Midcontinent Rift, formed as the North American continent began to split apart about 1.1 billion years ago. As the earth's crust thinned, magma rose toward the surface. These intrusions formed a -thick si... |
from a drug overdose in a downtown motel, set up for Quinlan to "discover" her. Instead, Quinlan strangles Grandi there and leaves his corpse with Susie. When she wakes up, she screams for help but instead is arrested on suspicion of murder. Vargas confronts Menzies about Quinlan's history of "discovering" incriminatin... | 1958 American film noir written and directed by Orson Welles, who also stars in the film. The screenplay was loosely based on the contemporary Whit Masterson novel Badge of Evil (1956). The cast included Charlton Heston, Janet Leigh, Joseph Calleia, Akim Tamiroff, and Marlene Dietrich. In 1956, Universal-International ... |
engineer, who authored multiple project articles for computer and electronics magazines of the 1970s, including Popular Electronics, Radio Electronics, Dr. Dobb's Journal, 73 Magazine, and Byte. He has written books on electronics, computers, and entrepreneurship, both commercially published and self-published. An earl... | is now known as print-on-demand technology. Lancaster produced his self-published books by re-purposing the game port of an Apple II to transfer PostScript code directly to a laser printer, rather than using a Macintosh running PageMaker. This enabled continuous book production using an inexpensive Apple II, rather tha... |
biggest graveyard in the Czech Republic New Jewish Cemetery, Prague – built next to the Olšany Cemetery to alievate the space problems faced by the Old Jewish Cemetery, it is the burial place of Franz Kafka Vyšehrad cemetery, Prague – the Czech Republic's most important cemetery, it is the burial site for Antonín Dvořá... | Americas Argentina La Recoleta Cemetery, Buenos Aires – burial site of Eva Perón, Federico Leloir, and many other Argentine figures La Chacarita Cemetery (or "National Cemetery"), Buenos Aires – burial site of Juan Peron (until 2006), Carlos Gardel and many other notables. Cementerio del Oeste, Tucumán Cementerio San J... |
13 other municipalities in the metropolitan region of Campinas, the city is subject to some environmental stress, and Campinas is considered one of the areas liable to flooding and silting; it now has less than 5% of vegetation cover in total area. Tryinh to reverse this situation, several projects have been and are be... | of 1,080,999 and a population density of 1358.6 (inhabitants / km ²). Infant mortality levels were at up to 1 year (per thousand): 14.05 and life expectancy in the city was 72.22 years. The fertility rate was at 1.78 children per woman. 96.01 of the populace could read. Human Development Index (HDI-M): 0.852 (high) HDI... |
storage and processing facilities for the cargo terminal expanded, and the passenger terminal was entirely revamped. A third phase of expansion, which would build a second runway by 2013, was projected. However, since the airport was conceded in 2012, the deadline for the new runway was postponed until 2018. Being the ... | of the 20th century, during an annual fair, there was a misunderstanding between the parish priest and the residents of the neighborhood. This resulted in excessive drinking and quarrels, in which the festival booths were torn down, or overturned, during the confusion. The name "Viracopos" was later used by the priest ... |
the U.S. Treasury named Davis as the highest-paid woman in the country, with her share of the film's profit accounting for most of her earnings. Her next film was Deception (1946), the first of her films to lose money. Possessed (1947) had been tailor-made for Davis, and was to have been her next project after Deceptio... | her second husband died unexpectedly. She raised her children largely as a single parent. Her daughter, B. D. Hyman, wrote a controversial memoir about her childhood, 1985's My Mother's Keeper. Davis was the co-founder of the Hollywood Canteen, a club venue for food, dancing and entertainment for servicemen during Worl... |
Fonda to play," and Jonathan Rosenbaum of the San Diego Reader felt that Fonda was "a marvel to watch; what fascinates and involves me in her performance are the conscientious effort and thought that seem to go into every line reading and gesture, as if the question of what a captain's wife and former cheerleader was l... | was the most horrible thing I could possibly have done. It was just thoughtless. In a 60 Minutes interview on March 31, 2005, Fonda reiterated that she had no regrets about her trip to North Vietnam in 1972, with the exception of the anti-aircraft-gun photo. She stated that the incident was a "betrayal" of American for... |
disease. There is usually an abrupt transition between unaffected tissue and the ulcer—a characteristic sign known as skip lesions. Under a microscope, biopsies of the affected colon may show mucosal inflammation, characterized by focal infiltration of neutrophils, a type of inflammatory cell, into the epithelium. This... | intake, or in severe cases, total parenteral nutrition (TPN). Most people with moderate or severe Crohn's disease are referred to a dietitian for assistance in nutrition. Small intestinal bacterial overgrowth (SIBO) is characterized by excessive proliferation of colonic bacterial species in the small bowel. Potential c... |
the soundtrack album of Coal Miner's Daughter, which peaked at number two on the Billboard Top Country Albums Chart and garnered her a nomination for the Grammy Award for Best Female Country Vocal Performance. She also released a studio album, Hangin' Up My Heart (1983), which was critically well received and peaked at... | Arnold A. Spacek (who served as mayor of Granger, Texas, in Williamson County). Actor Rip Torn was a first cousin; his mother Thelma Torn (née Spacek) was an elder sister of Sissy's father Edwin. Spacek's mother, who was of English and Irish descent, was from the Rio Grande Valley of Texas. At age six, Spacek performed... |
with its rotors inside the wingspan. In 2013, Bell Helicopter CEO John Garrison responded to Boeing's taking a different airframe partner for the US Army's future lift requirements by indicating that Bell would take the lead itself in developing the Bell V-280 Valor, with Lockheed Martin. In 2014, the Clean Sky 2 progr... | the lift via the forward motion of the entire aircraft. Since the rotors can be configured to be more efficient for propulsion (e.g. with root-tip twist) and it avoids a helicopter's issues of retreating blade stall, the tiltrotor can achieve higher cruise speeds and takeoff weights than helicopters. A tiltrotor aircra... |
mildly and severely reduced bone mineral density, are often present in people with coeliac disease, and investigations to measure bone density may be performed at diagnosis, such as dual-energy X-ray absorptiometry (DXA) scanning, to identify the risk of fracture and need for bone protection medication. Gluten withdraw... | rare. The only known effective treatment is a strict lifelong gluten-free diet, which leads to recovery of the intestinal lining (mucous membrane), improves symptoms, and reduces the risk of developing complications in most people. If untreated, it may result in cancers such as intestinal lymphoma, and a slightly incre... |
a corrupt U.S. senator in Mr. Smith Goes to Washington (1939), for which he received his first Academy Award nomination as Best Supporting Actor. For Warner Bros., he played Dr. Alexander Tower, who commits murder-suicide to spare his daughter a life of insanity in Kings Row (1942) and the cynical police chief Captain ... | The Apple Cart and dramatisations of The Constant Nymph and Pearl S. Buck's novel The Good Earth (as a Chinese farmer). Although he had played the single supporting role in the silent, Build Thy House (1920), Rains came relatively late to film acting. While working for the Theatre Guild, he was offered a screen test wi... |
in the inflorescence are very specialised, sometimes reduced to small scales, divided or dissected. Leafy inflorescences: Though often reduced in size, the bracts are unspecialised and look like the typical leaves of the plant, so that the term flowering stem is usually applied instead of inflorescence. This use is not... | above the subtending leaf, it is described as concaulescent. Organization There is no general consensus in defining the different inflorescences. The following is based on Focko Weberling's Morphologie der Blüten und der Blütenstände (Stuttgart, 1981). The main groups of inflorescences are distinguished by branching. W... |
pathway into carbon dioxide and ketone bodies. It has been shown that N-butyrate helps supply nutrients to this epithelial barrier. Studies have proposed that hydrogen sulfide plays a role in impairing this beta-oxidation pathway by interrupting the short chain acetyl-CoA dehydrogenase, an enzyme within the pathway. Fu... | clinical practice. Imaging is otherwise of limited use in diagnosing ulcerative colitis. Magnetic resonance imaging (MRI) is necessary to diagnose underlying PSC. Differential diagnosis Several conditions may present in a similar manner as ulcerative colitis, and should be excluded. Such conditions include: Crohn's dis... |
that adding ash from beech or birch in the boiling water, would break down the protein chains and speed up the process. The introduction of lye in the preparation process might therefore have been incidental. Preparation For it to become edible, lutefisk must again be soaked in cold water. The first step is soaking for... | deposits in the area favored the drying process for the preservation of whitefish - a process known for millennia. Stockfish is very nutrient-rich and was consumed domestically, although it was during the boom in the stockfish trade in the late Middle Ages that the product became accessible throughout Scandinavia, as w... |
performance in the title role of the 1942 film Mrs. Miniver. Early life Greer Garson was born on 29 September 1904 in Manor Park, East Ham (then in Essex, now part of London), the only child of Nancy Sophia "Nina" (née Greer; 1880-1958) and George Garson (1865–1906), a commercial clerk in a London importing business. H... | Pidgeon. The Guinness Book of World Records credits her with the longest Oscar acceptance speech, at five minutes and 30 seconds, after which the Academy Awards instituted a time limit. In Random Harvest, she co-starred with Ronald Colman. The drama received seven Academy Award nominations, including Colman for Best Ac... |
it exists in its zwitterionic form with its amine group protonated (as −NH3+) and its carboxyl group deprotonated (as −CO2−). It is non-essential to humans as it can be synthesised metabolically and does not need to be present in the diet. It is encoded by all codons starting with GC (GCU, GCC, GCA, and GCG). The L-iso... | glycolysis, gluconeogenesis, and the citric acid cycle. Chemical synthesis L-Alanine is produced industrially by decarboxylation of L-aspartate by the action of aspartate 4-decarboxylase. Fermentation routes to L-alanine are complicated by alanine racemase. Racemic alanine can be prepared by the condensation of acetald... |
or enantiomers of aspartic acid. The name "aspartic acid" can refer to either enantiomer or a mixture of two. Of these two forms, only one, "L-aspartic acid", is directly incorporated into proteins. The biological roles of its counterpart, "D-aspartic acid" are more limited. Where enzymatic synthesis will produce one o... | mammals.[3] In proteins aspartate sidechains are often hydrogen bonded to form asx turns or asx motifs, which frequently occur at the N-termini of alpha helices. The L-isomer of Asp is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. Aspartic acid, like glutamic acid, is classified as an ... |
mass-producing a crystalline salt of glutamic acid, monosodium glutamate. Synthesis Biosynthesis Industrial synthesis Glutamic acid is produced on the largest scale of any amino acid, with an estimated annual production of about 1.5 million tons in 2006. Chemical synthesis was supplanted by the aerobic fermentation of ... | occurs in some special contexts, such as the cell walls of the bacteria (which can manufacture it from the form with the enzyme glutamate racemase) and the liver of mammals. History Although they occur naturally in many foods, the flavor contributions made by glutamic acid and other amino acids were only scientifically... |
the chemical shifts of N1 and N3 are approximately 185 and 170 ppm. Ligand Histidine forms complexes with many metal ions. The imidazole sidechain of the histidine residue commonly serves as a ligand in metalloproteins. One example is the axial base attached to Fe in myoglobin and hemoglobin. Poly-histidine tags (of si... | The first reaction of histidine biosynthesis is the condensation of PRPP and adenosine triphosphate (ATP) by the enzyme ATP-phosphoribosyl transferase. ATP-phosphoribosyl transferase is indicated by His1 in the image. His4 gene product then hydrolyzes the product of the condensation, phosphoribosyl-ATP, producing phosp... |
hence it must be ingested, usually as a component of proteins. In plants and microorganisms, it is synthesized via several steps, starting from pyruvate and alpha-ketobutyrate. Enzymes involved in this biosynthesis include: Acetolactate synthase (also known as acetohydroxy acid synthase) Acetohydroxy acid isomeroreduct... | and microorganisms, it is synthesized via several steps, starting from pyruvate and alpha-ketobutyrate. Enzymes involved in this biosynthesis include: Acetolactate synthase (also known as acetohydroxy acid synthase) Acetohydroxy acid isomeroreductase Dihydroxyacid dehydratase Valine aminotransferase Catabolism Isoleuci... |
catalyses a condensation reaction with glutamate and NAD(P)H, as a proton donor, and the imine is reduced to produce the penultimate product, saccharopine. The final step of the pathway in fungi involves the saccharopine dehydrogenase (SDH) (E.C 1.5.1.8) catalysed oxidative deamination of saccharopine, resulting in L-l... | group (NH3+) is attached to the fourth carbon from the α-carbon, which is attached to the carboxyl (C=OOH) group. Due to its importance in several biological processes, a lack of lysine can lead to several disease states including defective connective tissues, impaired fatty acid metabolism, anaemia, and systemic prote... |
metabolism are acetyl-CoA and acetoacetate; consequently, it is one of the two exclusively ketogenic amino acids, with lysine being the other. It is the most important ketogenic amino acid in humans. Leucine and β-hydroxy β-methylbutyric acid, a minor leucine metabolite, exhibit pharmacological activity in humans and h... | metabolism occurs in many tissues in the human body; however, most dietary leucine is metabolized within the liver, adipose tissue, and muscle tissue. Adipose and muscle tissue use leucine in the formation of sterols and other compounds. Combined leucine use in these two tissues is seven times greater than in the liver... |
is another cause. Medications There are seven classes of medications associated with acute pancreatitis: statins, ACE inhibitors, oral contraceptives/hormone replacement therapy (HRT), diuretics, antiretroviral therapy, valproic acid, and oral hypoglycemic agents. Mechanisms of these drugs causing pancreatitis are not ... | abdominal disease, bowel sounds may be reduced from reflex bowel paralysis. Fever or jaundice may be present. Chronic pancreatitis can lead to diabetes or pancreatic cancer. Unexplained weight loss may occur from a lack of pancreatic enzymes hindering digestion. Complications Early complications include shock, infectio... |
1828 as asparagine itself. The determination of asparagine's structure required decades of research. The empirical formula for asparagine was first determined in 1833 by the French chemists Antoine François Boutron Charlard and Théophile-Jules Pelouze; in the same year, the German chemist Justus Liebig provided a more ... | the addition of carbohydrate chains. Typically, a carbohydrate tree can solely be added to an asparagine residue if the latter is flanked on the C side by X-serine or X-threonine, where X is any amino acid with the exception of proline. Asparagine can be hydroxylated in the HIF1 hypoxia inducible transcription factor. ... |
visits for pain treated with a parenterally administered narcotic or ketorolac (sickle cell crises), on average, compared to subjects who received a placebo (median 3 vs. median 4), fewer hospitalizations for sickle cell pain (median 2 vs. median 3), and fewer days in the hospital (median 6.5 days vs. median 11 days). ... | who had two or more painful crises within the 12 months prior to enrollment in the trial. Subjects were assigned randomly to treatment with L-glutamine oral powder or placebo, and the effect of treatment was evaluated over 48 weeks. Subjects who were treated with L-glutamine oral powder experienced fewer hospital visit... |
the codons CGU, CGC, CGA, CGG, AGA, and AGG. Arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. Preterm infants are unable to synthesize or create arginine internally, making the amino acid nutritionally essential fo... | is a conditionally essential amino acid in humans and rodents, as it may be required depending on the health status or lifecycle of the individual. Healthy adults usually produce enough arginine for their own body requirements, but immature and rapidly growing individuals require additional arginine in their diet. Addi... |
enantiomer), serves as a neuromodulator by coactivating NMDA receptors, making them able to open if they then also bind glutamate. D-serine is a potent agonist at the glycine site (NR1) of the NMDA-type glutamate receptor (NMDAR). For the receptor to open, glutamate and either glycine or D-serine must bind to it; in ad... | is produced from glycine and methanol catalyzed by hydroxymethyltransferase. Racemic serine can be prepared in the laboratory from methyl acrylate in several steps: Biological function Metabolic Serine is important in metabolism in that it participates in the biosynthesis of purines and pyrimidines. It is the precursor... |
to a variety of different GH families, such as glycoside hydrolase family 15 in fungi, glycoside hydrolase family 31 of human MGAM, and glycoside hydrolase family 97 of bacterial forms. Uses Fermentation α- and β-amylases are important in brewing beer and liquor made from sugars derived from starch. In fermentation, ye... | They belong to glycoside hydrolase family 14. Both α-amylase and β-amylase are present in seeds; β-amylase is present in an inactive form prior to germination, whereas α-amylase and proteases appear once germination has begun. Many microbes also produce amylase to degrade extracellular starches. Animal tissues do not c... |
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