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The mTOR inhibitor everolimus induces proteinuria and renal deterioration in the remnant kidney model in the rat. | BACKGROUND
Under certain circumstances the nonnephrotoxic, antiproliferative, immunosuppressive mammalian target of rapamycin (mTOR) inhibitors can cause renal deterioration and proteinuria after conversion from calcineurin inhibitors, especially in long-term renal transplant patients with low glomerular filtration rat... | 10.1097/01.tp.0000282866.92367.99 | 18,091,526 | D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D004195:Disease Models, Animal; D004727:Endothelium; D000068338:Everolimus; D005920:Glomerular Mesangium; D007674:Kidney Diseases; D008297:Male; D011494:Protein Kinases; D011507:Proteinuria; D012333:RNA, Messenger; D051381:Rats; D017207:Rats, Sprague-Dawle... | Transplantation | 2,007 | D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D000068338:Everolimus; D011494:Protein Kinases; C546845:mTOR protein, rat; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus |
An integrated framework of spatiotemporal dynamics of binocular rivalry. | Fluctuations in perceptual dominance during binocular rivalry exhibit several hallmark characteristics. First, dominance switches are not periodic but, instead, stochastic: perception changes unpredictably. Second, despite being stochastic, average durations of rivalry dominance vary dependent on the strength of the ri... | 10.3389/fnhum.2011.00088 | 21,941,473 | Frontiers in human neuroscience | 2,011 | ||
Changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation. | OBJECTIVES
The present study was designed to reveal changes in the collagen network architecture and collagen content in cartilage during growth and maturation of pigs.
METHODS
Femoral groove articular cartilage specimens were collected from 4-, 11- and 21-month-old domestic pigs (n=12 in each group). The animal care... | 10.1016/j.joca.2008.09.004 | 18,849,174 | D000375:Aging; D000818:Animals; D002358:Cartilage, Articular; D003094:Collagen; D005260:Female; D008859:Microscopy, Polarization; D017550:Spectroscopy, Fourier Transform Infrared; D034421:Sus scrofa | Osteoarthritis and cartilage | 2,009 | D003094:Collagen |
Synthesis and preliminary evaluation of (R,R)(S,S) 5-(2-(2-[4-(2-[(18)F]fluoroethoxy)phenyl]-1-methylethylamino)-1-hydroxyethyl)-benzene-1,3-diol ([(18)F]FEFE) for the in vivo visualisation and quantification of the beta2-adrenergic receptor status in lung. | The (18)F-labeled beta2-adrenergic receptor ligand (R,R)(S,S) 5-(2-(2-[4-(2-[(18)F]fluoroethoxy)phenyl]-1-methylethylamino)-1-hydroxyethyl)-benzene-1,3-diol, a derivative of the original highly selective racemic fenoterol, was synthesized in an overall radiochemical yield of 20% after 65 min with a radiochemical purity... | 10.1016/s0960-894x(03)00538-9 | 12,873,495 | D000818:Animals; D005280:Fenoterol; D005462:Fluorine Radioisotopes; D066298:In Vitro Techniques; D008168:Lung; D008956:Models, Chemical; D019275:Radiopharmaceuticals; D018343:Receptors, Adrenergic, beta-2; D013552:Swine; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed | Bioorganic & medicinal chemistry letters | 2,003 | D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D018343:Receptors, Adrenergic, beta-2; D005280:Fenoterol |
The thyrotrophic role of human chorionic gonadotrophin (hCG) in the early stages of twin (versus single) pregnancies. | OBJECTIVE
Human chorionic gonadotrophin (hCG) is known to possess thyroid-stimulating activity. The aim of the present study was to assess the role of hCG in stimulating the maternal thyroid gland in the early stages of normal gestation.
STUDY DESIGN
Thirty euthyroid healthy women were investigated prospectively. In ... | 10.1046/j.1365-2265.1997.2011011.x | 9,274,703 | D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D005307:Fertilization in Vitro; D015292:Glycoprotein Hormones, alpha Subunit; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011272:Pregnancy, Multiple; D011446:Prospective Studies; D013972:Thyr... | Clinical endocrinology | 1,997 | D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D015292:Glycoprotein Hormones, alpha Subunit; D013972:Thyrotropin; D013974:Thyroxine |
Relationship between iron status and exercise in male and female growing rats. | Weanling rats of both sexes were fed for 6 weeks diets containing 42, 17 or 7 ppm iron to produce adequate, moderately deficient and severely deficient iron status, respectively. At each level of iron, rats were either sedentary, trained regularly on a treadmill or housed in activity wheel cages. The moderately and sev... | 10.1093/jn/111.9.1648 | 7,277,042 | D000818:Animals; D004734:Energy Metabolism; D005260:Female; D006128:Growth; D006321:Heart; D006454:Hemoglobins; D007501:Iron; D000090463:Iron Deficiencies; D008297:Male; D009043:Motor Activity; D009929:Organ Size; D005082:Physical Exertion; D051381:Rats; D012737:Sex Factors | The Journal of nutrition | 1,981 | D006454:Hemoglobins; D007501:Iron |
[Panuveitis as a possible ophthalmic complication of Kikuchi-Fujimoto disease]. | CLINICAL CASE
A 37 year old female with histologically proven Kikuchi-Fujimoto disease is presented. She developed panuveitis, vasculitis and subretinal macular infiltrate, probably as a recurrence of the disease. Immunosuppressive treatment (methotrexate) was initiated in the absence of response to systemic steroid th... | 10.4321/s0365-66912005000100008 | 15,692,893 | D000328:Adult; D000964:Antimetabolites, Antineoplastic; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005938:Glucocorticoids; D020042:Histiocytic Necrotizing Lymphadenitis; D006801:Humans; D008727:Methotrexate; D015864:Panuveitis; D031300:Retinal Vasculitis; D01689... | Archivos de la Sociedad Espanola de Oftalmologia | 2,005 | D000964:Antimetabolites, Antineoplastic; D005938:Glucocorticoids; D008727:Methotrexate |
Discontinuation syndrome in newborns whose mothers took antidepressants while pregnant or breastfeeding. | OBJECTIVE
This study compared mothers' report of symptoms of discontinuation syndrome in infants exposed to antidepressants both in utero and during lactation to infants who were exposed only during lactation.
STUDY DESIGN
This is a convenience sample of 930 women breastfeeding women who answered an online questionna... | 10.1089/bfm.2010.0011 | 20,807,106 | D000328:Adult; D000928:Antidepressive Agents; D001942:Breast Feeding; D003866:Depressive Disorder; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008895:Milk, Human; D009357:Neonatal Abstinence Syndrome; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011795:Surveys and Questi... | Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine | 2,010 | D000928:Antidepressive Agents |
Validation of the surgical pain scales in women undergoing pelvic reconstructive surgery. | OBJECTIVE
Surgical pain scales (SPS) consist of 4 items that measure pain at rest, during normal activities, and during work/exercise and quantify unpleasantness of worst pain, which are valid and responsive in men undergoing hernia repair. Our objective was to evaluate the psychometric properties of SPS in women under... | 10.1097/SPV.0b013e31825d65aa | 22,777,367 | D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D010147:Pain Measurement; D010149:Pain, Postoperative; D056887:Pelvic Organ Prolapse; D011237:Predictive Value of Tests; D011594:Psychometrics; D015203:Reproducibility of Results; D012146:Rest; D014550:Uri... | Female pelvic medicine & reconstructive surgery | 2,012 | |
Serum magnesium and C-reactive protein levels. | OBJECTIVE
To assess the hypothesis that magnesium deficiency is associated with elevated high-sensitivity C-reactive protein (hsCRP) levels.
DESIGN
Community-based cross-sectional study.
SETTING
488 apparently healthy children aged 10-13 years were randomly enrolled from Durango, a city in northern Mexico, through ... | 10.1136/adc.2006.109371 | 17,641,003 | D000293:Adolescent; D001786:Blood Glucose; D015992:Body Mass Index; D002097:C-Reactive Protein; D002648:Child; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008274:Magnesium; D008275:Magnesium Deficiency; D008297:Male; D008800:Mexico; D009765:Obesi... | Archives of disease in childhood | 2,008 | D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002097:C-Reactive Protein; D008274:Magnesium |
New insights into aluminum tolerance in rice: the ASR5 protein binds the STAR1 promoter and other aluminum-responsive genes. | Aluminum (Al) toxicity in plants is one of the primary constraints in crop production. Al³⁺, the most toxic form of Al, is released into soil under acidic conditions and causes extensive damage to plants, especially in the roots. In rice, Al tolerance requires the ASR5 gene, but the molecular function of ASR5 has remai... | 10.1093/mp/sst160 | 24,253,199 | D000535:Aluminum; D018506:Gene Expression Regulation, Plant; D012275:Oryza; D010940:Plant Proteins; D011401:Promoter Regions, Genetic; D011485:Protein Binding | Molecular plant | 2,014 | D010940:Plant Proteins; D000535:Aluminum |
Relocation of a malpositioned maxillary implant with piezoelectric osteotomies: a case report. | Implant relocation is a new surgical technique for correcting the alignment of malpositioned implants by mobilizing them with the surrounding bone until the desired position is achieved. In this case report, a 25-year-old woman was treated for the malposition of an implant in the maxillary left canine site. The use of ... | 18,991,000 | D000328:Adult; D016025:Bone Transplantation; D003442:Crowns; D003481:Cuspid; D000044:Dental Abutments; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008437:Maxilla; D01... | The International journal of periodontics & restorative dentistry | 2,008 | D015921:Dental Implants | |
Structures of two cockroach neuropeptides assigned by fast atom bombardment mass spectrometry. | Amino acid sequences have been assigned to two cockroach neuropeptides (greater than Glu-Val-Asn-Phe-Ser-Pro-Asn-Trp-NH2, M I, and greater than Glu-Leu-Thr-Phe-Thr-Pro-Asn-Trp-NH2, M II) by application of fast atom bombardment mass spectrometry, including high resolution and linked scan (metastable) studies. The peptid... | 10.1016/0006-291x(84)91560-2 | 6,548,628 | D000595:Amino Acid Sequence; D000818:Animals; D003058:Cockroaches; D013058:Mass Spectrometry; D009419:Nerve Tissue Proteins; D009479:Neuropeptides | Biochemical and biophysical research communications | 1,984 | D009419:Nerve Tissue Proteins; D009479:Neuropeptides; C043192:glutamyl-valyl-asparaginyl-phenylalanyl-seryl-prolyl-asparaginyl-tryptophanamide; C043191:glutamyl-leucyl-threonyl-phenylalanyl-threonyl-prolyl-asparaginyl-tryptophanamide |
Effects of a glandless cottonseed protein diet on fasting plasma amino acid levels in college women. | Plasma amino acids were determined and correlated to the level of dietary amino acids consumed over a 42-day period. Six college women, ages 19 to 23, were fed meals in which 99% of the dietary protein was supplied by glandless cottonseed flour. The protein content was decreased weekly from 14.6 to 9.9, 8.7, 7.5, 6.9, ... | 10.1093/ajcn/33.2.287 | 6,892,588 | D000328:Adult; D000596:Amino Acids; D000601:Amino Acids, Essential; D003369:Cottonseed Oil; D004044:Dietary Proteins; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005260:Female; D006801:Humans; D010940:Plant Proteins | The American journal of clinical nutrition | 1,980 | D000596:Amino Acids; D000601:Amino Acids, Essential; D003369:Cottonseed Oil; D004044:Dietary Proteins; D010940:Plant Proteins |
[Evaluation of the usefulness of palpation and Daniel's biopsy for detection of metastasis to supraclavicular and scalene lymph nodes in patients with lung neoplasms]. | In 169 patients with lung cancer the usefulness of physical examination and Daniel's biopsy in detection of metastases to supraclavicular and scalene lymph nodes were evaluated. In 35 patients with palpable lymph nodes and in 25 patients with nonpalpable lymph nodes metastases were confirmed by histological examination... | 8,983,444 | D000328:Adult; D000368:Aged; D001706:Biopsy; D002277:Carcinoma; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008175:Lung Neoplasms; D008207:Lymphatic Metastasis; D008297:Male; D008654:Mesothelioma; D008875:Middle Aged; D009367:Neoplasm Staging; D010173:Palpation; D010997:Pleural Neoplasms; D012680:Sen... | Pneumonologia i alergologia polska | 1,996 | ||
Energy expenditure in young adult urban informal settlement dwellers in South Africa. | Obesity prevalences are increasing in industrialized and developing countries. As a pilot for a comparative study of physical activity and weight change, we assessed energy expenditure (EE) in young black South African adults living in an urban informal settlement. Total EE (TEE) was assessed using doubly labeled water... | 10.1038/ejcn.2008.75 | 19,156,156 | D000328:Adult; D004734:Energy Metabolism; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity; D010865:Pilot Projects; D015995:Prevalence; D012737:Sex Factors; D013019:South Africa; D013997:Time Factors; D014504:Urban Health; D055815:Young Adult | European journal of clinical nutrition | 2,009 | |
An open-label, single-dose, parallel-group study of the effects of chronic hepatic impairment on the safety and pharmacokinetics of desvenlafaxine. | BACKGROUND
Many antidepressants are extensively metabolized in the liver, requiring dose adjustments in individuals with hepatic impairment. Clinical studies indicate that the serotonin-norepinephrine reuptake inhibitor desvenlafaxine is metabolized primarily via glucuronidation, and ∼45% is eliminated unchanged in uri... | 23,623,756 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents; D003511:Cyclohexanols; D000069468:Desvenlafaxine Succinate; D005260:Female; D006801:Humans; D008099:Liver; D008107:Liver Diseases; D008297:Male; D008875:Middle Aged; D014179:Neurotransmitter Uptake Inhibitors; D055815:Young Adult | Clinical therapeutics | 2,013 | D000928:Antidepressive Agents; D003511:Cyclohexanols; D014179:Neurotransmitter Uptake Inhibitors; D000069468:Desvenlafaxine Succinate | |
CT diagnosis of acquired intercostal lung herniation. | Intercostal lung herniation is a rare complication of trauma, best demonstrated by computed tomography. Most intercostal lung herniations are the result of direct trauma to the chest wall or occur at sites of prior percutaneously placed chest tubes. We present two cases of acquired intercostal lung herniation. | 10.1016/0899-7071(95)00098-4 | 9,095,384 | D000368:Aged; D000369:Aged, 80 and over; D006547:Hernia; D006801:Humans; D008171:Lung Diseases; D008297:Male; D008875:Middle Aged; D013352:Subcutaneous Emphysema; D013898:Thoracic Injuries; D014057:Tomography, X-Ray Computed | Clinical imaging | 1,997 | |
Association of marijuana smoking with oropharyngeal and oral tongue cancers: pooled analysis from the INHANCE consortium. | BACKGROUND
The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950.
METHODS
A pooled analysis was conducted comprising individual-level data from nine case-control studies from the United States and Latin ... | 10.1158/1055-9965.EPI-13-0181 | 24,351,902 | D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell; D016022:Case-Control Studies; D005260:Female; D006258:Head and Neck Neoplasms; D006801:Humans; D015994:Incidence; D007843:Latin America; D008297:Male; D008385:Marijuana Smoking; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms;... | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology | 2,014 | |
Density gradients at hydrogel interfaces for enhanced cell penetration. | We report that stiffness gradients facilitate infiltration of cells through otherwise cell-impermeable hydrogel interfaces. By enabling the separation of hydrogel manufacturing and cell seeding, and by improving cell colonization of additively manufactured hydrogel elements, interfacial density gradients present a prom... | 10.1039/c4bm00416g | 26,222,418 | D001672:Biocompatible Materials; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D020100:Hydrogels | Biomaterials science | 2,015 | D001672:Biocompatible Materials; D020100:Hydrogels |
Characterization of putative stem cell populations in the cornea using synchrotron infrared microspectroscopy. | PURPOSE
High-resolution synchrotron radiation-based Fourier transform infrared (SR-FTIR) microspectroscopy coupled with multivariate analysis was used to investigate the characteristics of putative adult stem cell (SC), transiently amplified (TA) cell, and terminally differentiated (TD) cell populations of the corneal ... | 10.1167/iovs.05-1254 | 16,723,451 | D000818:Animals; D002417:Cattle; D002454:Cell Differentiation; D017357:Cyclotrons; D019573:Epithelium, Corneal; D016850:Limbus Corneae; D015591:Microspectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared; D013234:Stem Cells | Investigative ophthalmology & visual science | 2,006 | |
Effects of a D-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycemia in type 2 diabetes. | OBJECTIVE
Macronutrient "preloads" can reduce postprandial glycemia by slowing gastric emptying and stimulating glucagon-like peptide-1 (GLP-1) secretion. An ideal preload would entail minimal additional energy intake and might be optimized by concurrent inhibition of dipeptidyl peptidase-4 (DPP-4). We evaluated the ef... | 10.2337/dc12-2294 | 23,359,361 | D000368:Aged; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2; D054873:Dipeptidyl-Peptidase IV Inhibitors; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005746:Gastric Emptying; D052216:Glucagon-Like Peptide 1; D006801:Humans; D007328:Insulin; D008297:Male; D008875:Middle Aged; D019518:Postprandi... | Diabetes care | 2,013 | D001786:Blood Glucose; D054873:Dipeptidyl-Peptidase IV Inhibitors; D007328:Insulin; D011719:Pyrazines; D014230:Triazoles; D052216:Glucagon-Like Peptide 1; D014994:Xylose; D000068900:Sitagliptin Phosphate |
A new insight into viral proteins as Immunomodulatory therapeutic agents: KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein. | The physiologic function of the immune system is defense against infectious microbes and internal tumour cells, Therefore, need to have precise modulatory mechanisms to maintain the body homeostasis. The mammalian cellular CD200 (OX2)/CD200R interaction is one of such modulatory mechanisms in which myeloid and lymphoid... | 27,096,058 | Iranian journal of basic medical sciences | 2,016 | |||
Evaluation of granulocyte transfusion in healthy neonatal pony foals. | Granulocyte transfusions (GT), 0.98 X 10(9) neutrophils/kg of body weight, were performed on 7 healthy pony foals between 2 and 7 days old. The mean neutrophil count of the foals was significantly (P less than 0.05) greater than base line (4,830 +/- 1,260/microliter) 1 hour after GT (8,870 +/- 3,350/microliter) and was... | 3,631,706 | D000818:Animals; D000831:Animals, Newborn; D001803:Blood Transfusion; D005260:Female; D006098:Granulocytes; D006736:Horses; D007937:Leukapheresis; D008297:Male | American journal of veterinary research | 1,987 | ||
Results of high-density silicone oil as a tamponade agent in macular hole retinal detachment in patients with high myopia. | BACKGROUND
To evaluate the use of high-density silicone oil (HDSO) as a tamponade agent for retinal detachment secondary to myopic macular hole.
METHODS
12 eyes of 12 patients with macular hole retinal detachment underwent pars plana vitrectomy, internal limiting membrane peeling and HDSO tamponade. No posturing was ... | 10.1136/bjo.2006.111526 | 17,229,801 | D000368:Aged; D000369:Aged, 80 and over; D019773:Epiretinal Membrane; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative; D011312:Pressure; D011446:Prospective Studies; D012163:Retinal Detachment; D012167:Retinal Perforations; D012827:Silicone Oils; D014792:Visual Acuity; D0... | The British journal of ophthalmology | 2,007 | D012827:Silicone Oils |
Measurement of the activation of IL-2 on bone marrow by flow cytometry. | The changes of cell surface markers before and after activation by IL-2 were detected by flow cytometry (FCM) to establish a more convenient and precise criterion for the judgment of the activation of bone marrow. By using the measurement of the release of lactate dehydrogenase (LDH) the cytotoxicity of mononuclear cel... | 10.1007/BF02886958 | 12,938,513 | D001854:Bone Marrow Cells; D053282:CD27 Ligand; D005434:Flow Cytometry; D006801:Humans; D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit | Journal of Tongji Medical University = Tong ji yi ke da xue xue bao | 1,999 | D053282:CD27 Ligand; D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit |
[DNA degradation of porcine retinal cells for estimation of postmortem interval]. | OBJECTIVE
To investigate DNA degradation of porcine retinal cells by single cell gel electrophoresis (SCGE) for estimation of postmortem interval (PMI).
METHODS
Degradation of retinal cells was observed by SCGE at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22 and 24h after death respectively, under the environmental conditi... | 20,967,948 | D000818:Animals; D002467:Cell Nucleus; D020552:Comet Assay; D004247:DNA; D049429:Forensic Pathology; D007091:Image Processing, Computer-Assisted; D011180:Postmortem Changes; D012160:Retina; D013552:Swine; D013997:Time Factors | Fa yi xue za zhi | 2,010 | D004247:DNA | |
Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases. | S-adenosylmethionine (AdoMet)-based methylation is integral to metabolism and signaling. AdoMet-dependent methyltransferases belong to multiple distinct classes and share a catalytic mechanism that arose through convergent evolution; however, fundamental determinants underlying this shared methyl transfer mechanism rem... | 10.1021/ja407140k | 24,093,804 | D002244:Carbon; D019143:Evolution, Molecular; D006860:Hydrogen Bonding; D008780:Methyltransferases; D015394:Molecular Structure; D010100:Oxygen; D011789:Quantum Theory; D012436:S-Adenosylmethionine | Journal of the American Chemical Society | 2,013 | D002244:Carbon; D012436:S-Adenosylmethionine; D008780:Methyltransferases; D010100:Oxygen |
Effect of acetazolamide on rat gastric mucosal protection and stimulated bicarbonate secretion with 16,16-dimethyl PGE2. | The effect of pretreatment with acetazolamide, a carbonic anhydrase inhibitor, was studied on the mucosal protection provided by and the gastric alkaline secretion stimulated by 16,16-dimethyl prostaglandin E2. Using a model employing a chamber of the rat whole stomach, 16,16-dimethyl prostaglandin E2 (1 microgram/ml) ... | 6,491,473 | D015064:16,16-Dimethylprostaglandin E2; D000086:Acetazolamide; D000818:Animals; D001639:Bicarbonates; D000431:Ethanol; D005753:Gastric Mucosa; D006863:Hydrogen-Ion Concentration; D008297:Male; D009336:Necrosis; D011459:Prostaglandins E, Synthetic; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemica... | The Journal of laboratory and clinical medicine | 1,984 | D001639:Bicarbonates; D011459:Prostaglandins E, Synthetic; D000431:Ethanol; D015064:16,16-Dimethylprostaglandin E2; D000086:Acetazolamide | |
[Spontaneous contractions and the visco-elastic properties of the isolated guinea-pig gall-bladder]. | The isolated guinea-pig gall-bladder showed the spontaneous changes in luminal pressure at the rate of 7-12/min at 38 degrees C. These spontaneous contractions were increased in rates as the increase in luminal volume. On the other hand, they were reduced in rates and in amplitudes by lowering the temperatures. Decreas... | 10.1540/jsmr1965.21.71 | 4,057,714 | D000818:Animals; D002118:Calcium; D004548:Elasticity; D005704:Gallbladder; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth; D013696:Temperature; D013779:Tetrodotoxin | Nihon Heikatsukin Gakkai zasshi | 1,985 | D013779:Tetrodotoxin; D002118:Calcium |
Design of a CMOS Potentiostat Circuit for Electrochemical Detector Arrays. | High-throughput electrode arrays are required for advancing devices for testing the effect of drugs on cellular function. In this paper, we present design criteria for a potentiostat circuit that is capable of measuring transient amperometric oxidation currents at the surface of an electrode with submillisecond time re... | 10.1109/TCSI.2006.888777 | 20,514,150 | IEEE transactions on circuits and systems. I, Regular papers : a publication of the IEEE Circuits and Systems Society | 2,007 | ||
[Effect of thermal cycling on surface microstructure of different light-curing composite resins]. | OBJECTIVE
To evaluate the effect of thermal cycling on surface microstructure of different light-curing composite resins.
METHODS
A nanofilled composite (Z350) and 4 microhybrid composites (P60, Z250, Spectrum, and AP-X) were fabricated from lateral to center to form cubic specimens. The lateral surfaces were abrased... | 25,907,957 | D003188:Composite Resins; D003775:Dental Polishing; D055115:Light-Curing of Dental Adhesives; D008422:Materials Testing; D013499:Surface Properties; D013696:Temperature | Nan fang yi ke da xue xue bao = Journal of Southern Medical University | 2,015 | D003188:Composite Resins | |
Amyloid beta peptides inside a reconstituted cell-like liposomal system: aggregation, FRET, fluorescence oscillations and solvation dynamics. | Aggregations of amyloid-beta (Aβ) peptides were studied inside a reconstituted cell like liposomal system using time-resolved confocal microscopy. Fluorescence correlation spectroscopy (FCS) and confocal images indicate that Aβ forms a very large aggregate in bulk and more efficiently, in the bilayer region of the lipo... | 10.1039/c6cp06143e | 27,781,218 | D016229:Amyloid beta-Peptides; D008081:Liposomes; D066329:Protein Aggregates | Physical chemistry chemical physics : PCCP | 2,016 | D016229:Amyloid beta-Peptides; D008081:Liposomes; D066329:Protein Aggregates |
Pump induced lasing suppression in Yb:Er-doped microlasers. | A pump source is one of the essential prerequisites in order to achieve lasing in a system, and, in most cases, a stronger pump leads to higher laser power at the output. However, this behavior may be suppressed if two pump beams are used. In this work, we show that lasing around the 1600 nm band can be suppressed comp... | 10.1364/OE.25.024679 | 29,041,414 | Optics express | 2,017 | ||
Expanding STEM opportunities through inclusive STEM-focused high schools. | Inclusive STEM high schools (ISHSs) (where STEM is science, technology, engineering, and mathematics) admit students on the basis of interest rather than competitive examination. This study examines the central assumption behind these schools-that they provide students from subgroups underrepresented in STEM with exper... | 10.1002/sce.21281 | 28,919,649 | Science education | 2,017 | ||
Optical modeling of the emission zone profile and optimal emitter position based on the internal field profile of the air mode in organic light-emitting diodes. | We propose a theoretical formulation to calculate the internal profile of the air mode in the organic light-emitting diode (OLED) on the combination of the transfer matrix method and source-term method. The spatial distributions of the air mode are calculated in a top-emitting OLED with respect to the light polarizatio... | 10.1364/AO.57.008394 | 30,461,794 | Applied optics | 2,018 | ||
Marker-dependent hazard estimation: an application to AIDS. | The acquired immunodeficiency syndrome (AIDS) results from infection with the human immunodeficiency virus (HIV). The time of infection is generally unknown since transmission usually occurs during the course of repeated sexual contacts or needle sharing. Brookmeyer and Gail describe the biases that may arise in surviv... | 10.1002/sim.4780120905 | 8,101,012 | D000163:Acquired Immunodeficiency Syndrome; D000328:Adult; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes; D015331:Cohort Studies; D016001:Confidence Intervals; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D016016:Proportional Hazards Models; D01144... | Statistics in medicine | 1,993 | |
Child and adolescent predictors of smoking involvement in emerging adulthood. | OBJECTIVE
This study examined the differential relationship of externalizing behavior, internalizing behavior, social context, and their interactions to three developmental indicators of smoking involvement: onset (age), amount of smoking, and dependence symptomatology.
METHOD
Participants (n = 504, 73% male) from a ... | 10.1037/hea0000703 | 30,652,912 | D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012307:Risk Factors; D012907:Smoking; D014029:Tobacco Use Disorder; D055815:Young Adult | Health psychology : official journal of the Division of Health Psychology, American Psychological Association | 2,019 | |
Clinical trial and post-licensure safety profile of a prophylactic human papillomavirus (types 6, 11, 16, and 18) l1 virus-like particle vaccine. | BACKGROUND
We describe the safety of the human papillomavirus (HPV)-6/11/16/18 vaccine using updated clinical trial data (median follow-up time of 3.6 years) and summarize up to 3 years of post-licensure surveillance.
METHODS
In 5 clinical trials, 21,480 girls/women aged 9 to 26 years and boys aged 9 to 16 years rece... | 10.1097/INF.0b013e3181b77906 | 19,952,863 | D000293:Adolescent; D000328:Adult; D002648:Child; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005334:Fever; D006261:Headache; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D006801:Humans; D015994:Incidence; D008297:Male; D010146:Pain; D030361:Papill... | The Pediatric infectious disease journal | 2,010 | D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D053918:Papillomavirus Vaccines; D010919:Placebos; D022721:Vaccines, Virosome |
Identification and distribution of the costimulatory receptor CD28 in the mouse. | T cell activation requires Ag-specific stimulation mediated by the TCR as well as an additional stimulus provided by Ag presenting cells. On human T cells, it has been shown that antibodies to the Ag CD28 can provide a potent amplification signal for cytokine production and proliferation. Here we describe the productio... | 1,320,641 | D000818:Animals; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens; D006224:Cricetinae; D016572:Cyclosporine; D005260:Female; D005333:Fetus; D007106:Immune Sera; D007376:Interleukin-2; D008213:Lymphocyte Activation; D008647:Mesocricetus; D051379... | Journal of immunology (Baltimore, Md. : 1950) | 1,992 | D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens; D007106:Immune Sera; D007376:Interleukin-2; D016572:Cyclosporine | |
Synchronous hepatocellular carcinoma and lymphoepithelioma-like carcinoma arising from 2 different sites of the liver: A case report. | RATIONALE
Most cases of primary liver cancer involve hepatocellular carcinoma (HCC). Lymphoepithelioma-like carcinoma (LELC) is defined as a tumor composed of undifferentiated epithelial cells with a prominent lymphoid infiltrate, which is rarely reported. Lymphoepithelioma-like HCC (LEL-HCC) is an uncommon variant of ... | 10.1097/MD.0000000000012548 | 30,290,612 | D000368:Aged; D006528:Carcinoma, Hepatocellular; D005260:Female; D019694:Hepatitis B, Chronic; D006801:Humans; D007633:Keratins; D008113:Liver Neoplasms | Medicine | 2,018 | D007633:Keratins |
Nanoparticle-Based Strategies to Combat COVID-19. | Coronavirus disease 2019 (COVID-19) is the worst pandemic disease of the current millennium. This disease is caused by the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first exhibited human-to-human transmission in December 2019 and has infected millions of people within months ... | 10.1021/acsanm.0c01978 | 37,556,239 | ACS applied nano materials | 2,020 | ||
MIND, Anti-Psychiatry, and the Case of the Mental Hygiene Movement's 'Discursive Transformation'. | During the 1970s the National Association for Mental Health (NAMH) re-labelled itself MIND, becoming a rights-based organisation, critiquing psychiatry and emphasising patients' citizenship. Its transformation has been coloured by attributions of the influence of anti-psychiatry. This article argues that the relevance ... | 10.1093/shm/hky096 | 32,419,741 | Social history of medicine : the journal of the Society for the Social History of Medicine | 2,020 | ||
Adjacent-level biomechanics after single-level anterior cervical interbody fusion with anchored zero-profile spacer versus cage-plate construct: a finite element study. | BACKGROUND
The development of adjacent segment degeneration (ASD) following ACDF is well established. There is no analytical study related to effects of plate profile on the biomechanics of the adjacent-level after ACDF. This study aimed to test the effects of plate profile on the adjacent-level biomechanics after sing... | 10.1186/s12893-020-00729-4 | 32,252,742 | D000328:Adult; D001696:Biomechanical Phenomena; D001860:Bone Plates; D002574:Cervical Vertebrae; D017586:Diskectomy; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D016059:Range of Motion, Articular; D013123:Spinal Fusion | BMC surgery | 2,020 | |
Isoflurane increases cell membrane fluidity significantly at clinical concentrations. | There is an on-going debate whether anesthetic drugs, such as isoflurane, can cause meaningful structural changes in cell membranes at clinical concentrations. In this study, the effects of isoflurane on lipid membrane fluidity were investigated using fluorescence anisotropy and spectroscopy. In order to get a complete... | 10.1016/j.bbamem.2019.183140 | 31,790,694 | D018685:Anesthetics, Inhalation; D004910:Erythrocyte Membrane; D006801:Humans; D007530:Isoflurane; D008051:Lipid Bilayers; D008081:Liposomes; D008560:Membrane Fluidity | Biochimica et biophysica acta. Biomembranes | 2,020 | D018685:Anesthetics, Inhalation; D008051:Lipid Bilayers; D008081:Liposomes; D007530:Isoflurane |
Structural basis of cell surface receptor recognition by botulinum neurotoxin B. | Botulinum neurotoxins (BoNTs) are potent bacterial toxins that cause paralysis at femtomolar concentrations by blocking neurotransmitter release. A 'double receptor' model has been proposed in which BoNTs recognize nerve terminals via interactions with both gangliosides and protein receptors that mediate their entry. O... | 10.1038/nature05411 | 17,167,418 | D000818:Animals; D001665:Binding Sites; D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A; D018360:Crystallography, X-Ray; D005732:Gangliosides; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D009474:Neurons; D016716:PC12 Cells; D017434:Protein Structure, Tertiary; D051381:Rats; D... | Nature | 2,006 | D005732:Gangliosides; D011956:Receptors, Cell Surface; D050825:Synaptosomal-Associated Protein 25; D050863:Synaptotagmin I; D050861:Synaptotagmin II; C096323:rimabotulinumtoxinB; D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A |
Sporadic Creutzfeldt-Jakob disease presenting as progressive nonfluent aphasia with speech apraxia. | Progressive non-fluent aphasia (PNFA) is typically associated with pathological changes consistent with frontotemporal lobar degeneration. A 65-year-old male presented with effortful speech, markedly impaired naming and features of speech apraxia, consistent with PNFA. Perceptuospatial function, calculation and executi... | 10.1097/WAD.0b013e318260ab27 | 22,732,678 | D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D057178:Primary Progressive Nonfluent Aphasia | Alzheimer disease and associated disorders | 2,013 | |
Investigation of skin microbiota reveals Mycobacterium ulcerans-Aspergillus sp. trans-kingdom communication. | Mycobacterium ulcerans secrete a series of non-ribosomal-encoded toxins known as mycolactones that are responsible for causing a disabling ulceration of the skin and subcutaneous tissues named Buruli ulcer. The disease is the sole non-contagion among the three most common mycobacterial diseases in humans. Direct contac... | 10.1038/s41598-021-83236-7 | 33,580,189 | D001228:Aspergillosis; D001230:Aspergillus; D002050:Burkina Faso; D054312:Buruli Ulcer; D004269:DNA, Bacterial; D005658:Fungi; D006801:Humans; D064307:Microbiota; D019911:Mycobacterium ulcerans; D012867:Skin | Scientific reports | 2,021 | D004269:DNA, Bacterial |
Increased expression of connexin 43 in the overactive neurogenic detrusor. | PURPOSE
The cellular mechanisms involved in unstable uncontrolled detrusor contractions in the human bladder remain unknown. One hypothesis, based on electron microscopical observations and animal studies, is that gap junctions are present in the human detrusor and are increased in patients with detrusor overactivity. ... | 10.1016/j.eururo.2004.08.020 | 15,548,450 | D000293:Adolescent; D000328:Adult; D002648:Child; D018031:Connexin 43; D005260:Female; D006801:Humans; D008297:Male; D009130:Muscle, Smooth; D001743:Urinary Bladder; D001750:Urinary Bladder, Neurogenic | European urology | 2,004 | D018031:Connexin 43 |
The histone methyltransferase SMYD2 methylates PARP1 and promotes poly(ADP-ribosyl)ation activity in cancer cells. | Poly(ADP-ribose) polymerase-1 (PARP1) catalyzes the poly(ADP-ribosyl)ation of protein acceptors using NAD(+) as the substrate is now considered as an important target for development of anticancer therapy. PARP1 is known to be post-translationally modified in various ways including phosphorylation and ubiquitination, b... | 24,726,141 | D000595:Amino Acid Sequence; D004249:DNA Damage; D006367:HeLa Cells; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D006861:Hydrogen Peroxide; D008239:Lysine; D008745:Methylation; D008969:Molecular Sequence Data; D000071137:Poly (ADP-Ribose) Polymerase-1; D011064:Poly Adenosine Diphosphate Ribose; D011065:... | Neoplasia (New York, N.Y.) | 2,014 | D011064:Poly Adenosine Diphosphate Ribose; D006861:Hydrogen Peroxide; D011495:Histone-Lysine N-Methyltransferase; C512569:SMYD2 protein, human; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; D008239:Lysine | |
Evaluation of bile acid malabsorption by plasma cholesterol precursor sterols in familial hypercholesterolaemia patients with and without ileal exclusion. | To evaluate the value of plasma cholesterol precursor sterols in the detection of bile acid malabsorption we measured these sterols in 14 familial hypercholesterolaemia patients, seven with and seven without an ileal exclusion. In the operated subjects bile acid malabsorption had induced a 4.8-fold increase in choleste... | 10.3109/00365518809085764 | 3,217,753 | D000328:Adult; D001647:Bile Acids and Salts; D002775:Cholestadienols; D002782:Cholestenes; D002784:Cholesterol; D003897:Desmosterol; D005243:Feces; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II; D007082:Ileum; D007810:Lanosterol; D008297:Male; D008875:Middle Aged; D013185:Squalene | Scandinavian journal of clinical and laboratory investigation | 1,988 | D001647:Bile Acids and Salts; D002775:Cholestadienols; D002782:Cholestenes; D007810:Lanosterol; D003897:Desmosterol; C024372:4,4-dimethyl-delta(8)-cholestenol; C013499:4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol; D013185:Squalene; C001521:lathosterol; D002784:Cholesterol; C008421:4-methylcholest-7-en-3-ol |
The brain basis of handwriting deficits in Chinese children with developmental dyslexia. | Abundant behavioral studies have demonstrated high comorbidity of reading and handwriting difficulties in developmental dyslexia (DD), a neurological condition characterized by unexpectedly low reading ability despite adequate nonverbal intelligence and typical schooling. The neural correlates of handwriting deficits r... | 10.1111/desc.13161 | 34,288,292 | D001921:Brain; D001931:Brain Mapping; D002648:Child; D002681:China; D004410:Dyslexia; D006236:Handwriting; D006801:Humans; D008279:Magnetic Resonance Imaging; D011932:Reading | Developmental science | 2,022 | |
Summation characteristics of the detection of compound gratings. | Many classical experiments have shown that two superimposed gratings are more easily detected than a single grating, in keeping with probability theory. Here we test the rules for the detection of 2-component compound gratings by extending the range of parameters used in previous experiments. Two complementary methods ... | 10.1016/j.visres.2009.05.006 | 19,460,399 | D000328:Adult; D015350:Contrast Sensitivity; D006801:Humans; D008875:Middle Aged; D009039:Motion Perception; D010364:Pattern Recognition, Visual; D010470:Perceptual Masking; D010775:Photic Stimulation; D011601:Psychophysics; D012684:Sensory Thresholds | Vision research | 2,009 | |
Acyl chains of phospholipase D transphosphatidylation products in Arabidopsis cells: a study using multiple reaction monitoring mass spectrometry. | BACKGROUND
Phospholipases D (PLD) are major components of signalling pathways in plant responses to some stresses and hormones. The product of PLD activity is phosphatidic acid (PA). PAs with different acyl chains do not have the same protein targets, so to understand the signalling role of PLD it is essential to analy... | 10.1371/journal.pone.0041985 | 22,848,682 | D017360:Arabidopsis; D020404:Glycerophospholipids; D013058:Mass Spectrometry; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D010739:Phospholipase D; D020156:Salicylic Acid | PloS one | 2,012 | D020404:Glycerophospholipids; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; C068564:phosphatidylbutanol; D010739:Phospholipase D; D020156:Salicylic Acid |
[Atypical facial pain--quality of IHS (International Headache Society) criteria and psychometric data]. | Atypical facial pain is generally an unclearly defined pain syndrome. We tested in 35 patients (31 women, 4 men) with a mean age of 53.2 +/- 14.9 years and a chronic facial pain syndrome the quality of the new diagnostic criteria of the International Headache Society (IHS), at the same time using the SCL-90-R (Self-Rep... | 1,436,249 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D004185:Disability Evaluation; D005157:Facial Pain; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010555:Personality Inventory; D012803:Sick Role; D013001:Somatoform Disorders | Der Nervenarzt | 1,992 | ||
Linking stress and injury in the farming environment: a secondary analysis of qualitative data. | The first step in injury prevention is to understand the injury problem. This includes examining the nature of the problem from the perspective of the target community. This article uses qualitative methods to explain the nature of the injury problem and identifies prevention strategies through a three-step process: id... | 10.1177/109019819602300207 | 8,744,874 | D000062:Accidents, Occupational; D000368:Aged; D000383:Agriculture; D005260:Female; D017144:Focus Groups; D006266:Health Education; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011340:Problem Solving; D012307:Risk Factors; D017751:Safety Management; D013315:Stress, Psychological; D01... | Health education quarterly | 1,996 | |
A novel gene STYK1/NOK is upregulated in estrogen receptor-alpha negative estrogen receptor-beta positive breast cancer cells following estrogen treatment. | The human STYK1/NOK protein is approximately 30-35% similar to mouse fibroblast growth factor receptor 3 and a kinase homologue in D. melanogaster in the tyrosine protein kinase region. STYK1/NOK was identified as being up regulated in MDA-MB-231, an estrogen receptor-alpha negative breast cancer cell line, following 1... | 10.1007/s11033-006-9047-1 | 17,415,682 | D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D020847:Estrogen Receptor Modulators; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D012333:RNA, Messenger; D020794:Receptor Protein-Tyrosine Kinases; D013997:Time Fa... | Molecular biology reports | 2,008 | D020847:Estrogen Receptor Modulators; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens; D012333:RNA, Messenger; D020794:Receptor Protein-Tyrosine Kinases; C482299:STYK1 protein, human |
Thyroid nodules and cancer in children and adolescents affected by autoimmune thyroiditis. | OBJECTIVE
To investigate the association between juvenile autoimmune thyroiditis (JAT) and thyroid cancer in pediatric patients.
DESIGN
We conducted a retrospective study among children and adolescents affected by JAT.
SETTINGS
Data from 6 Italian pediatric endocrinology centers were collected.
PARTICIPANTS
Three... | 10.1001/archpedi.162.6.526 | 18,524,742 | D000293:Adolescent; D044963:Biopsy, Fine-Needle; D002291:Carcinoma, Papillary; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007558:Italy; D008207:Lymphatic Metastasis; D008297:Male; D016017:Odds Ratio; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Fact... | Archives of pediatrics & adolescent medicine | 2,008 | |
Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. | The vasodilator/antiproliferative peptide angiotensin-(1-7) [ANG-(1-7)] is released into the corpus cavernosum sinuses, but its role in erectile function has yet to be defined. In this study, we sought to determine whether ANG-(1-7) and its receptor Mas play a role in erectile function. The ANG-(1-7) receptor Mas was i... | 10.1152/ajpheart.00173.2007 | 17,616,753 | D000803:Angiotensin I; D000804:Angiotensin II; D000818:Animals; D003900:Desoxycorticosterone; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004791:Enzyme Inhibitors; D007172:Erectile Dysfunction; D006973:Hypertension; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL;... | American journal of physiology. Heart and circulatory physiology | 2,007 | C092006:7-Ala-angiotensin (1-7); D004791:Enzyme Inhibitors; D010446:Peptide Fragments; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-Coupled; D017673:Sodium Chloride, Dietary; D014665:Vasodilator Agents; D000804:Angiotensin II; D009569:Nitric Oxide; D003900:Desoxycorticost... |
Hypertension and risk of uterine leiomyomata in US black women. | BACKGROUND
Previous studies have found a positive association between hypertension and risk of hysterectomy-confirmed uterine leiomyomata (UL). The association of hypertension with UL confirmed by ultrasound or other surgery is less clear.
METHODS
The present study evaluated the association of hypertension with UL in... | 10.1093/humrep/des046 | 22,371,286 | D000328:Adult; D001741:Black or African American; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension; D007889:Leiomyoma; D018570:Risk Assessment; D014463:Ultrasonography; D014481:United States | Human reproduction (Oxford, England) | 2,012 | |
Salmonella infections in a marsupial, the quokka (Setonix brachyurus), in relation to seasonal changes in condition and environmental stress. | An unusual abundance of Salmonella infections was studied in an island population of a wild marsupial, the quokka (Setonix brachyurus), which experiences starvation in summer associated with significant mortality. The frequency of infections was found to vary seasonally over most parts of the island, with high infectio... | 10.1128/aem.49.5.1276-1281.1985 | 4,004,242 | D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D005243:Feces; D008394:Marsupialia; D012475:Salmonella; D012481:Salmonella Infections, Animal; D012621:Seasons; D013312:Stress, Physiological | Applied and environmental microbiology | 1,985 | |
Clinical evaluation of squamous cell carcinoma antigen in squamous cell carcinoma arising in mature cystic teratoma of the ovary. | We attempted to assess the clinical utility of squamous cell carcinoma antigen (SCC) for detecting squamous cell carcinoma arising in mature cystic teratoma of the ovary. SCC in serum from 16 patients with this malignancy and from 56 patients with mature cystic teratoma without malignancy was measured using radioimmuno... | 10.1159/000227475 | 7,777,241 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D010051:Ovarian Neoplasms; D015843:Serpins; D013724:Teratoma | Oncology | 1,995 | D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015843:Serpins; C051072:squamous cell carcinoma-related antigen |
Nosocomial legionellosis traced to a contaminated ice machine. | OBJECTIVE
To investigate a case of nosocomial legionellosis, identify pathways of transmission, and effect control of the environmental source.
DESIGN
Case investigation and environmental culture surveillance.
SETTING
A 720-bed university teaching hospital. CASE PATIENT: A ventilator-dependent 66-year-old male deve... | 10.1086/647689 | 9,309,436 | D000368:Aged; D003428:Cross Infection; D004197:Disease Reservoirs; D004866:Equipment Contamination; D006784:Hospitals, Teaching; D006801:Humans; D007053:Ice; D007877:Legionnaires' Disease; D008297:Male; D009518:New York; D014871:Water Microbiology | Infection control and hospital epidemiology | 1,997 | D007053:Ice |
Arthrogryposis and congenital absence of the anterior cruciate ligament: a case report. | Arthrogryposis is a non-progressive disorder with congenitally soft tissue contractures affecting two or more joints. It can be sporadic, or inherited in an autosomal dominant or recessive fashion. Typically, in the upper limb, the shoulder is in adduction and internal rotation, the elbow is in extension with a lack of... | 10.1016/j.knee.2008.08.004 | 18,819,806 | D016118:Anterior Cruciate Ligament; D001176:Arthrogryposis; D001915:Braces; D002675:Child, Preschool; D003025:Clubfoot; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D026741:Physical Therapy Modalities | The Knee | 2,009 | |
The Influence of Stroke Location on Cognitive and Mood Impairment. A Voxel-Based Lesion-Symptom Mapping Study. | BACKGROUND AND PURPOSE
The role of stroke location as a determinant of mood and cognitive symptoms is still a matter of debate. The aim of this study was to identify the predictive value of ischemic stroke location, on a voxel basis, for mood and cognitive outcome.
MATERIALS AND METHODS
A prospective monocentric stud... | 10.1016/j.jstrokecerebrovasdis.2019.01.010 | 30,718,064 | D000339:Affect; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain; D001931:Brain Mapping; D003071:Cognition; D003072:Cognition Disorders; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders; D... | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association | 2,019 | |
[An outbreak of enterocolitis due to Clostridium perfringens in a hospital for the severely disabled]. | We had an outbreak of 14 cases of enterocolitis due to Clostridium perfringens (Cl. perfringens) in a hospital for the severe multiply-disabled, where the 100 disabled were admitted, in summer in 1985. The signs and symptoms shown by this enterocolitis were primarily diarrhea without fever and loss of appetite. The fec... | 10.11150/kansenshogakuzasshi1970.63.410 | 2,550,564 | D000293:Adolescent; D000328:Adult; D002648:Child; D003016:Clostridium perfringens; D003428:Cross Infection; D006233:Disabled Persons; D004196:Disease Outbreaks; D004760:Enterocolitis; D005260:Female; D005516:Food Microbiology; D006801:Humans; D007564:Japan; D008297:Male | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases | 1,989 | |
Intestinal calcium absorption in the aged rat: evidence of intestinal resistance to 1,25(OH)2 vitamin D. | We investigated the role of circulating 1,25-dihydroxycholecalciferol (1,25(OH)2D) and intestinal resistance to 1,25(OH)2D in the diminished intestinal calcium absorption capacity of the senescent rat. We measured plasma 1,25(OH)2D, total and unoccupied duodenal vitamin D receptor, duodenal calbindin D9k protein (calbi... | 10.1210/endo.139.9.6176 | 9,724,038 | D000042:Absorption; D000375:Aging; D000818:Animals; D064026:Calbindins; D002136:Calcium, Dietary; D004351:Drug Resistance; D007413:Intestinal Mucosa; D007422:Intestines; D051381:Rats; D017207:Rats, Sprague-Dawley; D018167:Receptors, Calcitriol; D064030:S100 Calcium Binding Protein G; D014807:Vitamin D | Endocrinology | 1,998 | D064026:Calbindins; D002136:Calcium, Dietary; D018167:Receptors, Calcitriol; D064030:S100 Calcium Binding Protein G; C576506:S100G protein, human; C576508:S100g protein, rat; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D |
The impact of type 2 diabetes mellitus on daily functioning. | BACKGROUND
Traditionally, health and the outcomes of medical treatment have been measured in terms of morbidity, incidence or prevalence of disease, or even mortality. This disease model provides an adequate framework for acute illnesses, but for chronic diseases, severity and their effect on everyday functioning are p... | 10.1093/fampra/16.2.133 | 10,381,018 | D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases; D002908:Chronic Disease; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D016015:Logistic Models; D0082... | Family practice | 1,999 | |
Spirituality, religiosity, and dealing with illness in Arabic and German patients. | OBJECTIVE
To investigate the impact of spirituality and religiosity (SpR) in Arabic patients with a Muslim background as compared to patients from Western Germany.
METHODS
A total of 66 Arabic patients with hypertension were recruited between November 2005 and June 2006 consecutively at Al-Razi Hospital and Khalil Su... | 17,530,114 | D000328:Adult; D000368:Aged; D018912:Arabs; D002835:Christianity; D005260:Female; D005858:Germany; D006801:Humans; D007514:Islam; D008297:Male; D008875:Middle Aged; D012068:Religion and Medicine; D029181:Spirituality; D011795:Surveys and Questionnaires | Saudi medical journal | 2,007 | ||
Subcellular distribution of ATP-stimulated and ADP-inhibited acetyl-CoA hydrolase in livers from control and clofibrate-treated rats: comparison of the cytosolic and peroxisomal enzyme. | An extramitochondrial acetyl-CoA hydrolase [EC 3.1.2.1] in the rat liver, which is stimulated by ATP and inhibited by ADP, is known to be extremely cold-labile. During subcellular fractionations at low temperatures (2-4 degrees C), most of the enzyme activity was lost; however, most could be recovered by rewarming at 3... | 10.1093/oxfordjournals.jbchem.a124337 | 7,911,463 | D000104:Acetyl-CoA Hydrolase; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000818:Animals; D002458:Cell Fractionation; D002994:Clofibrate; D003080:Cold Temperature; D003600:Cytosol; D004789:Enzyme Activation; D008099:Liver; D008297:Male; D008830:Microbodies; D051381:Rats | Journal of biochemistry | 1,994 | D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000104:Acetyl-CoA Hydrolase; D002994:Clofibrate |
Effects of the head lift exercise and neuromuscular electrical stimulation on swallowing muscles activity in healthy older adults: a randomized pilot study. | PURPOSE
Swallowing physiology exhibits several changes in advanced ages. The present study aimed to investigate and compare effects of a period of the head lift exercise (HLE) and neuromuscular electrical stimulation (NMES) on swallowing muscles activity in healthy elderly.
PATIENTS AND METHODS
A total of 23 older ad... | 10.2147/CIA.S209055 | 31,417,244 | D000368:Aged; D000369:Aged, 80 and over; D003679:Deglutition; D003680:Deglutition Disorders; D004599:Electric Stimulation Therapy; D004576:Electromyography; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009334:Neck Muscles; D010865:Pilot Projects | Clinical interventions in aging | 2,019 | |
Rare aggressive solid pseudopapillary neoplasm of the ovary with metastatic disease following surgical resection. | Extra-pancreatic solid pseudopapillary neoplasms (SPNs) are rare tumours with an overall favourable prognosis and low malignant potential. SPNs with metastatic spread, distant lymph node metastasis and extrapancreatic origin are exceedingly rare. Significant controversy regarding the treatment and the management of met... | 10.1136/bcr-2020-238136 | 33,298,496 | D000328:Adult; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D008198:Lymph Nodes; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms; D049268:Positron-Emission Tomography | BMJ case reports | 2,020 | |
Antepartum reversal of hematologic abnormalities associated with the HELLP syndrome. A report of three cases. | The "HELLP syndrome" refers to the occurrence of thrombocytopenia, elevated liver enzymes and, at times, hemolysis in patients with preeclampsia. Although uncontrolled series have reported a reversal of thrombocytopenia and elevated liver enzymes with aspirin and colloid infusion, most authors recommend that delivery b... | 3,950,889 | D000328:Adult; D000410:Alanine Transaminase; D001510:Bed Rest; D005260:Female; D006461:Hemolysis; D006801:Humans; D008107:Liver Diseases; D010976:Platelet Count; D011225:Pre-Eclampsia; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D013577:Syndrome; D013921:Thrombocytopenia | The Journal of reproductive medicine | 1,986 | D000410:Alanine Transaminase | |
Deer browsing and soil disturbance induce cascading effects on plant communities: a multilevel path analysis. | Understanding how large herbivores shape plant diversity patterns is an important challenge in community ecology, especially because many ungulate populations in the northern hemisphere have recently expanded. Because species within plant communities can exhibit strong interactions (e.g., competition, facilitation), se... | 10.1890/09-2100.1 | 21,563,575 | D000818:Animals; D003670:Deer; D017753:Ecosystem; D005247:Feeding Behavior; D010944:Plants; D011792:Quebec; D012987:Soil | Ecological applications : a publication of the Ecological Society of America | 2,011 | D012987:Soil |
Effect of Wii-intervention on balance of children with poor motor performance. | The purpose of this study was to investigate the effects of training with the Wii-balance board on balance and balance-related skills of children with poor motor performance. Twenty-nine children (23 boys, 6 girls; aged 7-12 years) participated in this study and were randomly assigned to an experimental and control gro... | 23,827,983 | D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009048:Motor Skills; D019957:Motor Skills Disorders; D009068:Movement; D004856:Postural Balance; D016896:Treatment Outcome; D018910:Video Games | Research in developmental disabilities | 2,013 | ||
Quantitative proteomics reveals that dormancy-related proteins mediate the attenuation in mycobacterium strains. | Although members of the Mycobacterium tuberculosis complex (MTBC) exhibit high similarity, they are characterized by differences with respect to virulence, immune response, and transmissibility. To understand the virulence of these bacteria and identify potential novel therapeutic targets, we systemically investigated ... | 10.1080/21505594.2021.1965703 | 34,634,997 | D001500:BCG Vaccine; D006801:Humans; D009163:Mycobacterium bovis; D009169:Mycobacterium tuberculosis; D040901:Proteomics; D014376:Tuberculosis; D014774:Virulence; D037521:Virulence Factors | Virulence | 2,021 | D001500:BCG Vaccine; D037521:Virulence Factors |
Impact of Starmerella bacillaris and Zygosaccharomyces bailii on ethanol reduction and Saccharomyces cerevisiae metabolism during mixed wine fermentations. | The bulk of grape juice fermentation is carried out by the yeast Saccharomyces cerevisiae, but non-Saccharomyces yeasts can modulate many sensorial aspects of the final products in ways not well understood. In this study, some of such non-conventional yeasts were screened as mixed starter cultures in a defined growth m... | 10.1016/j.foodres.2022.111649 | 35,940,817 | D000431:Ethanol; D005285:Fermentation; D012441:Saccharomyces cerevisiae; D004718:Saccharomycetales; D014920:Wine | Food research international (Ottawa, Ont.) | 2,022 | D000431:Ethanol |
Drug network identification predicts injecting risk behavior among people who inject drugs on hepatitis C virus treatment in Tayside, Scotland. | The risk of Hepatitis C Virus (HCV) acquisition among People Who Inject Drugs (PWID) remains high when injecting risk behavior within networks endures. Several psychosocial factors influence such behavior. Following a drive within Tayside, a geographic region in Scotland, to achieve World Health Organization HCV elimin... | 10.1080/08964289.2022.2142501 | 36,411,523 | Behavioral medicine (Washington, D.C.) | 2,022 | ||
PROTOCOL: Treatment for depressive disorder among adults: An evidence and gap map of systematic reviews. | This is the protocol for a Campbell evidence and gap map. The objective of the map is to map available systematic reviews on the effectiveness of treatments for depressive disorders among adults. Specifically, this EGM includes studies on the effectiveness of treatments across a range of outcome domains. | 10.1002/cl2.1308 | 36,911,856 | Campbell systematic reviews | 2,023 | ||
Pediatric infectious disease physician perceptions of antimicrobial stewardship programs. | Pediatric antimicrobial stewardship programs (ASPs) improve antibiotic use for hospitalized children. Prescriber surveys indicate acceptance of ASPs, but data on infectious diseases (ID) physician opinions of ASPs are lacking. We conducted a survey of pediatric ID physicians, ASP and non-ASP, and their perceptions of A... | 10.1017/ice.2022.183 | 35,938,450 | D006801:Humans; D002648:Child; D000073602:Antimicrobial Stewardship; D000900:Anti-Bacterial Agents; D011795:Surveys and Questionnaires; D010820:Physicians; D003141:Communicable Diseases | Infection control and hospital epidemiology | 2,023 | D000900:Anti-Bacterial Agents |
Integration of Oral Health into Primary Health Care System: Views of Primary Health Care Workers in Lagos State, Nigeria. | The limited access to oral health care in developing countries can be greatly improved by integrating oral health into the Primary Health Care (PHC) system. This study was designed to assess the views of PHC workers on integrating oral health care into the PHC system. A self-administered questionnaire survey was conduc... | 10.4081/jphia.2014.328 | 28,299,117 | Journal of public health in Africa | 2,014 | ||
3D-QSAR studies of 2,2-diphenylpropionates to aid discovery of novel potent muscarinic antagonists. | Muscarinic acetylcholine receptors (mAChRs) consisting of five known subtypes, are widely distributed in both central and peripheral nervous systems for regulation of a variety of critical functions. The present theoretical study describes correlations between experimental and calculated molecular properties of 15 alph... | 10.1016/j.bmc.2009.04.001 | 19,409,797 | D000818:Animals; D001285:Atropine; D002460:Cell Line; D006168:Guinea Pigs; D007085:Ilium; D015394:Molecular Structure; D018727:Muscarinic Antagonists; D010179:Pancreas; D011422:Propionates; D021281:Quantitative Structure-Activity Relationship; D011789:Quantum Theory; D051381:Rats | Bioorganic & medicinal chemistry | 2,009 | D018727:Muscarinic Antagonists; D011422:Propionates; D001285:Atropine |
Video-assisted thoracoscopic treatment for spontaneous pneumothorax as two-day surgery. | BACKGROUND
To see whether video-assisted thoracoscopic surgery (VATS) for spontaneous pneumothorax (SP) as 2-day surgery is a safe and cost-effective procedure, we retrospectively compared VATS as 2-day surgery with standard VATS.
METHODS
From April 1994 to March 2000, 139 SP patients were operated on: 115 patients w... | 10.1016/s0002-9610(00)00448-7 | 11,084,122 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D007564:Japan; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011030:Pneumothorax; D011183:Postoperative Complications; D012189:Retrospective Studies; D020775:Thoracic Surgery, Vid... | American journal of surgery | 2,000 | |
Somatostatin mediates nitric oxide production by activating sst(2) receptors in the rat retina. | Somatostatin and its receptors (ssts) are found in the retina. Recent evidence suggested the involvement of sst(2A) and sst(2B) receptors in the regulation of nitric oxide (NO) (). In this study, we investigated further the localization of sst(1), sst(3)-sst(5), and the possible involvement of all subtypes, present in ... | 10.1016/s0028-3908(02)00181-8 | 12,384,175 | D000818:Animals; D002460:Cell Line; D005455:Fluorescent Antibody Technique; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins; D009252:NADPH Dehydrogenase; D009566:Nitrates; D009569:Nitric Oxide; D009573:Nitrites; D009924:Organ Culture Techniques; D051381:Rats; D017207:Rats, Sprague-... | Neuropharmacology | 2,002 | D008565:Membrane Proteins; D009566:Nitrates; D009573:Nitrites; D017481:Receptors, Somatostatin; C106140:somatostatin receptor sst2A; C098681:somatostatin receptor subtype-4; D009569:Nitric Oxide; D013004:Somatostatin; D009252:NADPH Dehydrogenase |
Identification of a disulfide bridge connecting the alpha-subunits of the extracellular domain of the insulin receptor. | The alpha 2 beta 2 structure of the insulin receptor has previously been shown to involve one disulfide bridge between the alpha-subunits in the region containing Cys435, Cys468 and Cys524. We have digested the soluble extracellular domain of the insulin receptor with succinylated trypsin, partially separated the resul... | 10.1016/0006-291x(92)92250-2 | 1,472,036 | D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D003545:Cysteine; D004220:Disulfides; D006801:Humans; D007668:Kidney; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D010446:Peptide Fragments; D011972:Receptor, Insuli... | Biochemical and biophysical research communications | 1,992 | D004220:Disulfides; D046911:Macromolecular Substances; D010446:Peptide Fragments; D011994:Recombinant Proteins; D011972:Receptor, Insulin; D014357:Trypsin; D003545:Cysteine |
Relocation after a disaster: posttraumatic stress disorder in Armenia after the earthquake. | OBJECTIVE
To explore the relationship between exposure to the earthquake in Armenia on December 7, 1988, and relocation from the disaster zone, and the subsequent development of posttraumatic stress disorder (PTSD), depression, and behavioral difficulties in children.
METHOD
The PTSD module of the Diagnostic Intervie... | 10.1097/00004583-199603000-00020 | 8,714,327 | D000293:Adolescent; D001136:Armenia; D002648:Child; D003866:Depressive Disorder; D004190:Disasters; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D013313:Stress Disorders, Post-Traumatic | Journal of the American Academy of Child and Adolescent Psychiatry | 1,996 | |
Population-based cohort study on the risk of pneumonia in patients with non-traumatic intracranial haemorrhage who use proton pump inhibitors. | OBJECTIVES
This nationwide cohort study investigated the association between proton pump inhibitor (PPI) usage and the risk of pneumonia in patients with non-traumatic intracranial haemorrhage (ICH).
DESIGN
Nationwide population-based cohort study.
SETTING
Longitudinal Health Insurance Database 2010 (LHID2010) samp... | 10.1136/bmjopen-2014-006710 | 25,384,687 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages; D008297:Male; D008875:Middle Aged; D011014:Pneumonia; D054328:Proton Pump Inhibitors; D012189:Retrospective Studies; D012306:Risk; D055815:Young Adult | BMJ open | 2,014 | D054328:Proton Pump Inhibitors |
The US framework for understanding, preventing, and caring for the mental health needs of service members who served in combat in Afghanistan and Iraq: a brief review of the issues and the research. | This paper reviews the psychological health research conducted in the United States in support of combat veterans from Iraq and Afghanistan, using the Military Psychological Health Research Continuum, which includes foundational science, epidemiology, etiology, prevention and screening, treatment, follow-up care, and s... | 10.3402/ejpt.v5.24713 | 25,206,943 | European journal of psychotraumatology | 2,014 | ||
Exploiting the effect of dietary supplementation of small ruminants on resilience and resistance against gastrointestinal nematodes. | This paper focuses on targeted nutritional supplementation as a means to reduce the requirement for chemotherapeutic control of gastrointestinal nematode infection of small ruminants and considers the limitations to practical application. Supplementary feeding, particularly with additional dietary protein, can assist r... | 10.1016/j.vetpar.2006.04.026 | 16,765,520 | D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D019587:Dietary Supplements; D004351:Drug Resistance; D015511:Goat Diseases; D006041:Goats; D007411:Intestinal Diseases, Parasitic; D009751:Nutritional Requirements; D012418:Ruminants; D012756:Sheep; D012757:Sheep Diseases | Veterinary parasitology | 2,006 | |
Mutagen sensitivity of Neurospora meiotic mutants. | The Neurospora meiotic mutants, mei-1, mei-2, mei-3, and mei-4 were tested for cross sensitivity to mutagens. Mei-2 and mei-3 are sensitive to MMS, gamma-irradiation and histidine. Mei-2 is not sensitive to ultraviolet (UV) at 20 degrees C. Tests with recombinants with crossovers to either side of mei-2 or mei-3 show t... | 10.1139/g83-003 | 6,220,799 | D000483:Alleles; D005720:Gamma Rays; D006639:Histidine; D006720:Homozygote; D008540:Meiosis; D008741:Methyl Methanesulfonate; D009153:Mutagens; D009154:Mutation; D009491:Neurospora; D009492:Neurospora crassa | Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie | 1,983 | D009153:Mutagens; D006639:Histidine; D008741:Methyl Methanesulfonate |
Metformin for weight reduction in non-diabetic patients on antipsychotic drugs: a systematic review and meta-analysis. | Weight gain is a clinically important side effect of antipsychotic drug therapy. The aim of this study was to determine the effect of the antidiabetic drug metformin on antipsychotic-induced weight gain in non-diabetic patients. In a systematic literature review we identified 195 citations from which seven randomized, ... | 10.1177/0269881109353461 | 20,080,925 | D000328:Adult; D014150:Antipsychotic Agents; D002648:Child; D006801:Humans; D007004:Hypoglycemic Agents; D008687:Metformin; D044469:Racial Groups; D015430:Weight Gain; D015431:Weight Loss | Journal of psychopharmacology (Oxford, England) | 2,011 | D014150:Antipsychotic Agents; D007004:Hypoglycemic Agents; D008687:Metformin |
MethyLight droplet digital PCR for detection and absolute quantification of infrequently methylated alleles. | Aberrant DNA methylation is a common epigenetic alteration found in colorectal adenomas and cancers and plays a role in cancer initiation and progression. Aberrantly methylated DNA loci can also be found infrequently present in normal colon tissue, where they seem to have potential to be used as colorectal cancer (CRC)... | 10.1080/15592294.2015.1068490 | 26,186,366 | D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D015179:Colorectal Neoplasms; D019175:DNA Methylation; D018450:Disease Progression; D006238:Haploidy; D006801:Humans; D016133:Polymerase Chain Reaction; D020812:Receptor, trkC; D012680:Sensitivity and Specificity | Epigenetics | 2,015 | D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C484449:EVL protein, human; D020812:Receptor, trkC |
Effect of calcium sulfate concentration in soymilk on the microstructure of firm tofu and the protein constitutions in tofu whey. | The effects of calcium sulfate concentration in soymilk on the microstructure of tofu and the constitutions of protein in tofu whey were investigated. The firm tofu made with 0.4% CaSO(4).2H(2)O was found to be most uniform and continuous in the microstructure. This tofu gave the maximal tofu yield, maximal solid and p... | 10.1021/jf0342021 | 14,518,946 | D002133:Calcium Sulfate; D004591:Electrophoresis, Polyacrylamide Gel; D005524:Food Technology; D005782:Gels; D008855:Microscopy, Electron, Scanning; D012996:Solutions; D030262:Soybean Proteins; D013025:Glycine max | Journal of agricultural and food chemistry | 2,003 | D005782:Gels; D012996:Solutions; D030262:Soybean Proteins; D002133:Calcium Sulfate |
Structure and relative stability of drum-like C4nN2n n = 3-8) cages and their hydrogenated products C4nH4nN2n (n = 3-8) cages. | The drum-like C4nNn (n = 3-8) cages and corresponding hydrogenated products C4n H4nN2n (n = 3-8) are studied at the DFT B3LYP/6-31G** level. Their structures, energies, and vibrational frequencies have been investigated. Comparison of heat of formation reveals that C32N16 with D8h symmetry in the C4nN2n (n = 3-8) serie... | 10.1021/jp801501g | 18,947,219 | The journal of physical chemistry. A | 2,008 | ||
Anti-N-methyl-D-aspartate receptor antibodies are associated with fibromyalgia in patients with systemic lupus erythematosus: a case-control study. | OBJECTIVES
The high concordance between systemic lupus erythematosus (SLE) and fibromyalgia (FM) suggests common underlying mechanisms related to pain and distress in both patient groups. Increasing evidence indicates that N-methyl-D-aspartate receptors (NMDARs) play a major role in the induction and maintenance of cen... | 28,339,361 | D000328:Adult; D001323:Autoantibodies; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D005356:Fibromyalgia; D006801:Humans; D008180:Lupus Erythematosus, Systemic; D020945:Lupus Vasculitis, Central Nervous System; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016194:Receptors, N-... | Clinical and experimental rheumatology | 2,017 | D001323:Autoantibodies; C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate | |
Automated detection and manipulation of sleep in C. elegans reveals depolarization of a sleep-active neuron during mechanical stimulation-induced sleep deprivation. | Across species, sleep is characterized by a complex architecture. Sleep deprivation is a classic method to study the consequences of sleep loss, which include alterations in the activity of sleep circuits and detrimental consequences on well being. Automating the observation and manipulation of sleep is advantageous to... | 10.1038/s41598-018-28095-5 | 29,950,594 | D000818:Animals; D001522:Behavior, Animal; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins; D056656:Lab-On-A-Chip Devices; D009474:Neurons; D015398:Signal Transduction; D012890:Sleep; D012892:Sleep Deprivation | Scientific reports | 2,018 | D029742:Caenorhabditis elegans Proteins |
An attempt to identify reproducible high-density EEG markers of PTSD during sleep. | STUDY OBJECTIVES
We examined electroencephalogram (EEG) spectral power to study abnormalities in regional brain activity in post-traumatic stress disorder (PTSD) during sleep. We aimed to identify sleep EEG markers of PTSD that were reproducible across nights and subsamples of our study population.
METHODS
Seventy-ei... | 10.1093/sleep/zsz207 | 31,553,047 | D000328:Adult; D001143:Arousal; D058256:Brain Waves; D004569:Electroencephalography; D005133:Eye Movements; D005260:Female; D005625:Frontal Lobe; D006801:Humans; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe; D017286:Polysomnography; D015203:Reproducibility of Results; D012895:Sleep, REM; D000077310:Sleep, S... | Sleep | 2,020 | |
Titin-Related Dilated Cardiomyopathy: The Clinical Trajectory and the Role of Circulating Biomarkers in the Clinical Assessment. | Titin truncating variants (TTNtv) are known as the leading cause of inherited dilated cardiomyopathy (DCM). Nevertheless, it is unclear whether circulating cardiac biomarkers are helpful in detection and risk assessment. We sought to assess 1) early indicators of cardiotitinopathy including the serum biomarkers high-se... | 10.3390/diagnostics12010013 | 35,054,181 | Diagnostics (Basel, Switzerland) | 2,021 | ||
Saralasin dilates arterioles in SHR but not WKY rats. | Microvascular responses to topical or intravascular saralasin were determined in the cremaster muscle arterioles of adult spontaneously hypertensive rats (SHR, n = 19) and Wistar-Kyoto (WKY, n = 16) normotensive rats. Animals were anesthetized with chloralose and urethane, and they breathed room air spontaneously. Mean... | 10.1161/01.hyp.6.2_pt_2.i106 | 6,724,666 | D000818:Animals; D001158:Arteries; D001160:Arterioles; D001794:Blood Pressure; D002339:Carotid Arteries; D006973:Hypertension; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D012504:Saralasin; D014664:Vasodilation | Hypertension (Dallas, Tex. : 1979) | 1,984 | D012504:Saralasin |
Challenging the clinically-situated emotion-deficient version of empathy within medicine and medical education research. | In this paper, we argue that the notion of a clinically-situated empathy (e.g. physician empathy), is potentially problematic as it perpetuates an emotion-deficient version of empathy within medicine and medicine education research. Utilizing classic and contemporary empathy theory from various social science disciplin... | 10.1057/s41285-021-00174-0 | 34,840,531 | Social theory & health : STH | 2,022 |
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