query dict | candidates listlengths 54 60 |
|---|---|
{
"doc_id": "29360039",
"title": "Crk proteins transduce FGF signaling to promote lens fiber cell elongation.",
"abstract": "Specific cell shapes are fundamental to the organization and function of multicellular organisms. Fibroblast Growth Factor (FGF) signaling induces the elongation of lens fiber cells during vertebrate lens development. Nonetheless, exactly how this extracellular FGF signal is transmitted to the cytoskeletal network has previously not been determined. Here, we show that the Crk family of adaptor proteins, Crk and Crkl, are required for mouse lens morphogenesis but not differentiation. Genetic ablation and epistasis experiments demonstrated that Crk and Crkl play overlapping roles downstream of FGF signaling in order to regulate lens fiber cell elongation. Upon FGF stimulation, Crk proteins were found to interact with Frs2, Shp2 and Grb2. The loss of Crk proteins was partially compensated for by the activation of Ras and Rac signaling. These results reveal that Crk proteins are important partners of the Frs2/Shp2/Grb2 complex in mediating FGF signaling, specifically promoting cell shape changes.",
"corpus_id": 3508568
} | [
{
"doc_id": "17901128",
"title": "Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.",
"abstract": "Binding of the fibroblast growth factor (FGF) to the FGF receptor (FGFR) tyrosine kinase leads to rec... |
{"doc_id":"29353941","title":"A Bayesian model selection approach for identifying differentially exp(...TRUNCATED) | [{"doc_id":"19417075","title":"A hierarchical Bayesian model for comparing transcriptomes at the ind(...TRUNCATED) |
{"doc_id":"29348350","title":"Draft Genome Sequences of 14 Strains of Pseudomonas Isolated from Prun(...TRUNCATED) | [{"doc_id":"22132095","title":"Pseudomonas syringae pv. actinidiae draft genomes comparison reveal s(...TRUNCATED) |
{"doc_id":"29372014","title":"A psychometric assessment of Disturbances in Self-Organization symptom(...TRUNCATED) | [{"doc_id":"22729974","title":"A critical evaluation of the complex PTSD literature: implications fo(...TRUNCATED) |
{"doc_id":"26787849","title":"SutA is a bacterial transcription factor expressed during slow growth (...TRUNCATED) | [{"doc_id":"18070067","title":"Sigma factors in Pseudomonas aeruginosa.","abstract":"In Pseudomonas (...TRUNCATED) |
{"doc_id":"29303981","title":"Development of a Machine Vision Method for the Monitoring of Laying He(...TRUNCATED) | [{"doc_id":"25629704","title":"Preliminary evaluation of a nest usage sensor to detect double nest o(...TRUNCATED) |
{"doc_id":"29329231","title":"Development of a Cytocompatible Scaffold from Pig Immature Testicular (...TRUNCATED) | [{"doc_id":"20047952","title":"Options for fertility preservation in prepubertal boys.","abstract":"(...TRUNCATED) |
{"doc_id":"29509720","title":"Segmentation of Oil Spills on Side-Looking Airborne Radar Imagery with(...TRUNCATED) | [{"doc_id":"22399940","title":"A fast level set method for synthetic aperture radar ocean image segm(...TRUNCATED) |
{"doc_id":"27164102","title":"3D Visual Data-Driven Spatiotemporal Deformations for Non-Rigid Object(...TRUNCATED) | [{"doc_id":"18592227","title":"Prediction of object contact during grasping.","abstract":"The maximu(...TRUNCATED) |
{"doc_id":"29046519","title":"The effects of anti-hypertensive drugs and the mechanism of hypertensi(...TRUNCATED) | [{"doc_id":"22311909","title":"Mice lacking hypertension candidate gene ATP2B1 in vascular smooth mu(...TRUNCATED) |
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