README.md

---
license: cc-by-4.0
pretty_name: STRING v12.0
tags:
- biology
- proteomics
- protein-protein-interaction
- graph
- string-db
configs:
- config_name: protein_links
  data_files:
  - split: train
    path: "data/protein_links/train-*.parquet"
  - split: validation
    path: "data/protein_links/validation-*.parquet"
  - split: test
    path: "data/protein_links/test-*.parquet"
- config_name: protein_info
  data_files:
  - split: train
    path: "data/protein_info/train-*.parquet"
  - split: validation
    path: "data/protein_info/validation-*.parquet"
  - split: test
    path: "data/protein_info/test-*.parquet"
- config_name: protein_aliases
  data_files:
  - split: train
    path: "data/protein_aliases/train-*.parquet"
  - split: validation
    path: "data/protein_aliases/validation-*.parquet"
  - split: test
    path: "data/protein_aliases/test-*.parquet"
- config_name: protein_sequences
  data_files:
  - split: train
    path: "data/protein_sequences/train-*.parquet"
  - split: validation
    path: "data/protein_sequences/validation-*.parquet"
  - split: test
    path: "data/protein_sequences/test-*.parquet"
- config_name: species
  data_files:
  - split: train
    path: "data/species/train-*.parquet"
  - split: validation
    path: "data/species/validation-*.parquet"
  - split: test
    path: "data/species/test-*.parquet"
---

# STRING v12.0

STRING is a protein association network database that integrates experimental, computational, text-mined, and curated evidence for functional and physical protein interactions.

## Configs

| Config | Raw source | Description |
| --- | --- | --- |
| `protein_links` | `protein.links.full.v12.0.txt.gz` | Protein-protein association edges with all STRING evidence channels and `combined_score`. |
| `protein_info` | `protein.info.v12.0.txt.gz` | Protein identifiers, preferred names, sizes, and annotations. |
| `protein_aliases` | `protein.aliases.v12.0.txt.gz` | External aliases and identifier sources for STRING proteins. |
| `protein_sequences` | `protein.sequences.v12.0.fa.gz` | Protein amino-acid sequences parsed from FASTA. |
| `species` | `species.v12.0.txt` | Organism metadata: taxonomy id, STRING type, compact name, official NCBI name, and domain. |

## Splits

The post-processing script assigns rows to `train`, `validation`, and `test` with a deterministic CRC32 hash. The default ratios are 98/1/1. Re-running with the same `--split-seed` gives the same split assignment.

Split keys:

| Config | Split key |
| --- | --- |
| `protein_links` | `protein1 + protein2` |
| `protein_info` | `string_protein_id` |
| `protein_aliases` | `string_protein_id + alias + source` |
| `protein_sequences` | `string_protein_id` |
| `species` | `taxon_id` |

## Usage

Install the client library:

```bash
python -m pip install datasets
```

Load the interaction table in streaming mode:

```python
from datasets import load_dataset

links = load_dataset("LiteFold/STRING", "protein_links", split="train", streaming=True)
first_row = next(iter(links))
print(first_row)
```

Load a smaller metadata table normally:

```python
from datasets import load_dataset

proteins = load_dataset("LiteFold/STRING", "protein_info", split="train")
print(proteins[0])
```

Load local Parquet files generated before upload:

```python
from datasets import load_dataset

data_files = {
    "train": "data/protein_links/train-*.parquet",
    "validation": "data/protein_links/validation-*.parquet",
    "test": "data/protein_links/test-*.parquet",
}
links = load_dataset("parquet", data_files=data_files, split="train", streaming=True)
```

## Post-processing

Install conversion dependencies:

```bash
python -m pip install -r requirements.txt
```

Create the full Parquet dataset using 32 worker processes:

```bash
python scripts/prepare_hf_dataset.py \
  --raw-dir v12.0 \
  --output-dir data \
  --num-proc 32 \
  --overwrite
```

Create a quick preview dataset before running the full conversion:

```bash
python scripts/prepare_hf_dataset.py \
  --raw-dir v12.0 \
  --output-dir data_preview \
  --tables species,protein_info,protein_links \
  --max-rows-per-table 10000 \
  --num-proc 32 \
  --overwrite
```

Useful options:

| Option | Purpose |
| --- | --- |
| `--num-proc 32` | Uses 32 parser workers. |
| `--rows-per-chunk 100000` | Controls rows parsed per worker task. Lower this if memory is tight. |
| `--max-in-flight 32` | Bounds queued chunks to avoid unbounded RAM growth. Defaults to `--num-proc`. |
| `--link-min-combined-score 700` | Optionally keep only higher-confidence links. |
| `--compression zstd` | Writes compressed Parquet shards. |

Validate generated local files:

```bash
python scripts/validate_hf_dataset.py --data-dir data --config protein_links --split train --streaming
```

Validate after upload:

```bash
python scripts/validate_hf_dataset.py --repo-id LiteFold/STRING --config protein_links --split train --streaming
```

## Upload

After generating `data/`, upload the processed files and this dataset card:

```bash
huggingface-cli upload LiteFold/STRING README.md README.md --repo-type dataset
huggingface-cli upload LiteFold/STRING data data --repo-type dataset
```

The repository already tracks `*.parquet` with Git LFS through `.gitattributes`.

## Citation

Please cite the upstream STRING database:

```bibtex
@article{szklarczyk2023string,
  title = {The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest},
  author = {Szklarczyk, Damian and Kirsch, Rebecca and Koutrouli, Mikaela and Nastou, Katerina and Mehryary, Farrokh and Hachilif, Radja and Gable, Annika L. and Fang, Tao and Doncheva, Nadezhda T. and Pyysalo, Sampo and Bork, Peer and Jensen, Lars J. and von Mering, Christian},
  journal = {Nucleic Acids Research},
  volume = {51},
  number = {D1},
  pages = {D638--D646},
  year = {2023},
  doi = {10.1093/nar/gkac1000}
}
```