text stringlengths 0 10.1k |
|---|
OBJECTIVE |
To assess the anxiolytic efficacy of pregabalin in patients with generalized anxiety disorder. |
DESIGN |
Double-blind, placebo-controlled, active-comparator trial. Patients were randomized to 4 weeks of treatment with pregabalin, 300 mg/d (n = 91), 450 mg/d (n = 90), or 600 mg/d (n = 89); alprazolam, 1.5 mg/d (n = 93); or placebo (n = 91). |
SETTING |
Psychiatry research and clinic settings. |
PATIENTS |
Outpatients meeting the DSM-IV criteria for generalized anxiety disorder, with a baseline Hamilton Anxiety Rating Scale (HAM-A) total score of 20 or greater. |
MAIN OUTCOME MEASURES |
Change from baseline to end point in total HAM-A score in the pregabalin and alprazolam groups compared with the placebo group. The end point response criterion was 50% or greater reduction in the HAM-A total score. |
RESULTS |
Pregabalin and alprazolam produced a significantly greater reduction in mean +/- SE HAM-A total score at last-observation-carried-forward end point compared with placebo (-8.4 +/- 0.8): pregabalin, 300 mg (-12.2 +/- 0.8, P<.001), 450 mg (-11.0 +/- 0.8, P = .02), and 600 mg (-11.8 +/- 0.8, P = .002), and alprazolam (-10... |
CONCLUSION |
Pregabalin was significantly more efficacious than placebo for the treatment of psychic and somatic symptoms of generalized anxiety disorder and was well tolerated by most study patients.Anticardiolipin antibodies and clinical spectrum of antiphospholipid syndrome in patients with systemic lupus erythematosus. |
In this paper we analyzed the clinical manifestation and course of the disease in 47 patients with systemic lupus erythematosus (SLE) and secondary antiphospholipid syndrome (APS) during prospective follow-up that lasted 2-5 years (mean 3.4). The most frequent features of APS were thrombosis (51%) thrombocytopenia (46.... |
Hypertrophic scars are pathological scars which result from exaggerated skin proliferation following a wound and injury. Although many theories have been implicated for keloidogenesis, the precise pathophysiological cause is still masked. Different treatment strategies have been tried in their management, but there is ... |
The objective: was to investigate the level of asthma control in adolescents using the PAQLQ questionnaire and spirometry. |
Materials and methods. The study included 60 adolescents aged 12 to 18 years, patients with asthma, without clinical and functional signs of exacerbation. 43.4% of adolescents (26 people) had a controlled course, and 56.6% of children (34 people) had a partially controlled asthma. |
Results. According to the results of bronchodilation tests 3 times more often showed a positive response when using a combined bronchodilator, compared with salbutamol (χ2y=4.37; p=0,04). The average increase in FEV1 was 1,4 times greater in children after the use of ipratropium bromide / fenoterol – 8,9±0,8%, compared... |
After evaluating the results of spirometry, the proportion of children with incomplete asthma control was 63,3%. Detected 38,5% of patients with a total QOL PAQLQ <6 points in controlled asthma. After conducting a survey on the PAQLQ questionnaire and spirometric examination, the percentage of children with incomplete ... |
Conclusion. Clinical monitoring is not always sufficient to properly assess the level of asthma control in adolescents. Consideration of several assessment methods makes it possible to more accurately determine the level of asthma control in a patient.Improvement of the Transfer Efficiency of the Atomized Powder Coatin... |
This paper deals with improvement of the transfer efficiency of powder coating by increasing the conveying air speed using the atomized powder coating (APC) system. In addition, the details of the powder-mass-flow-rate sensor, which forms the basis of the APC system and realizes sensor-based full automatic control of t... |
When protamine is added to actin, different supramolecular structures are formed depending on the molar ratio of the two proteins and of the ionic strength of the medium. At low ionic strength, and going from a molar ratio of protamine to G-actin of 4:1, 2:1 and 1:1, globular aggregates are first converted into extende... |
The nature of immune complexes and their relationship to the normal glomerular basement membrane (GBM) components type IV collagen, fibronectin, and heparan sulphate proteoglycans (HSPG) have been examined in the glomeruli of 7 cases of systemic lupus erythematosus (SLE) glomerulonephritis using an ultrastructural immu... |
Existing linear scheduling methods for earthwork activities lack accurate scheduling locations in road construction projects. Project planners and construction managers largely depend on subjective decisions for the allocation of resources at correct locations. This has caused uncertainties in planning and scheduling, ... |
Clinical standard 12-lead ECG recordings over 5 minutes on patients in atrial fibrillation or in atrial flutter were analyzed. After suppression of the signal components related to ventricular activity, the amplitude spectra of all leads were inspected. The spectrum of lead V1 clearly showed the presence of harmonics o... |
PURPOSE |
The indications of FDG PET-CT are well established for some neoplasms, such as lung cancer and lymphoma. The role of FDG PET-CT for the management of cutaneous melanoma is less clear. |
METHODS |
We successively describe the substances and machines used with PET-CT, and review the French recommendations and the latest scientific articles to determine which patients could benefit from this examination. |
RESULTS |
PET-CT is not indicated for the diagnosis of the malignancy of a suspicious cutaneous lesion, or for initial regional node staging. PET-CT is not indicated for the initial staging of melanoma without node involvement. PET-CT could be proposed for the staging of thick melanoma with macroscopic involvement of the sentine... |
Graphene and carbon nanotubes (CNTs) have gained significant attention due to their potential applications in high performance electronics. In order to replace or integrate the current silicon based technology with carbon based electronics one should study the reliability of those devices to understand the feasibility ... |
Science museums not only function as collection, exhibition, research, and leisure locations, but are also important sites for education. Thus, science museums often organize various activities to educate the public and deliver various key concepts. Museums organize diverse activities, such as exhibitions, lectures, ha... |
A purpose of the Interior Exploration Using Seismic Investigations, Geodesy and Heat Transport (InSight) mission is to reveal the Martian interior structure with seismic data. In this work, ambient noise autocorrelation of the continuously recorded vertical‐component seismic signals has extracted the Rayleigh waves tha... |
BACKGROUND |
Medicinal teas present one of the oldest galenic preparations of herbal remedies. Their use is primarily determined by tradition and empirics. One of their traditional domains are gastrointestinal disorders, which belong to the most frequent wellness disorders. While the effectiveness and compatibility of essential oil... |
PURPOSE |
The presented application observation in clinical practice tried to give evidence for effectiveness and tolerability of medicinal teas in the treatment of dyspeptic disorders and to quantify their extent. |
MATERIAL AND METHODS |
We collected information about effectiveness, compatibility, and side effects of herbal teas from 89 patients (w = 56; m = 33) suffering from dyspeptic disorders. The data were reported with a questionnaire that was sent to physicians and pharmacists experienced in phytotherapy. |
RESULTS |
It could be shown that complaints in patients with primary dyspeptic symptoms (n = 79) decreased by an average of 74%. Final overall assessment revealed that the physicians as well as the patients estimated an effectiveness of 2.9 points as good (3 = good). Compatibility was considered as good to very good (4 = very go... |
CONCLUSION |
The herbal teas can be considered effective, very well tolerable and to a large extent free from serious side effects. However, due to the limited observation time, no final conclusion could be given concerning long-term compatibility.Education for Gifted Minority Students |
are some general categories of concern which are common to most groups of students whose exceptional needs are not met by the usual public school supermarket-type education. These general categories, modified to relate to minority youngsters, provide a framework for a viable educational program for minority students wh... |
We study the problem of generating motion plans for kinematically controllable underactuated systems in environments cluttered with obstacles. We develop a computationally efficient motion planning algorithm that finds fast trajectories by exploiting closed-form inverse kinematics of the robot. The completeness propert... |
Many forces threaten the survival of the clinician-scientist as an academic species, among them: (1) the changing health environment; (2) the complexity of and rapid advances in biomedical science, which necessitate that MD-PhD graduates “retool” after completing their clinical training; (3) the length and rigor of the... |
Organisational innovativeness has been discussed as a paradigm industrywide (DeMiranda, et al., 2009) and as a national source of competitive advantage (Ludviga, 2012). Studies indicate that innovativeness might depend on leadership and leaders’ capacities to establish right organisational climate. Current study invest... |
Iron deficiency and anemia remain among the most important global public health problems facing school children. Helminth infections often peak at school age and aggravate nutritional risks. We conducted a 12-wk randomized controlled trial in 406 Malian anemic schoolchildren infected with Schistosoma hematobium to exam... |
Supply chain management (SCM) practices have become a key determinant of competitive advantage of business enterprises. Effectively carried out supply chain management prac-tices provide a strategic improvement to supply chain performance and thereby increases the performance of companies. The present study examines th... |
Year 2010 marked the 25th year since we came to know that roughness of a protein surface has fractal symmetry. Ever since the publication of Lewis and Rees' paper, hundreds of works from a spectrum of perspectives have established that fractal dimension (FD) can be considered as a reliable marker that describes roughne... |
Introduction: Home metal industry is an informal industry activity engaged in the manufacture of metal. The process of metal-making crates noise that causes hearing loss complaints in workers. The purpose of this study was to analyze the relationship between workers’ individual characteristics and hearing complaints in... |
ABSTRACT The differences of thermodynamics energies from the pure phase to a solution were used to predict the solubility properties of acidic phosphorus–containing rare-earth extractants. Four solvents, namely tributylphosphate, n-dodecane, toluene, and n-octanol were used. The thermodynamic cycle of the implicit solv... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.