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AIM |
Glucotoxicity obstructs pancreatic differentiation from adult stem cells. The aim was to develop a novel protocol for differentiation of dental pulp stem cells (DPSCs) into pancreatic β cells and determine the effect of H2S on glucotoxicity. |
MATERIALS & METHODS |
DPSCs were differentiated with media containing 5.5 or 25.0 mM glucose, exposed to 1 ng/ml H2S. Glucotoxicity, expression of β-cell markers, INS, PDX1 and GLUT2, and PI3K/AKT pathway were assessed. |
RESULTS |
H2S exposure increased insulin and C-peptide, and protected DPSC-derived pancreatic β-like cells from glucotoxicity and upregulated INS, PDX1 and GLUT2, and genes of PI3K/AKT pathway. |
CONCLUSION |
H2S improved effects of glucotoxicity on β-like cells via PI3K/AKT pathway. The protocol for pancreatic β-cell differentiation might have applications in regenerative medicine rather than swine pancreas transplantation.Dementia with bilateral medial tempora1 lobe ischemia |
Neuropathologic examination of two patients with dementia showed chronic bilateral medial temporal lobe ischemic damage that included the hippocampus (particularly the CA-1 region), subiculum, and amygdala. Both patients had several myocardial infarctions, and the relatively circumscribed cerebral injury may have resul... |
An investigation was carried out to study the effects of steel fibers in improving the performance of concrete under impact loading. Both conventionally reinforced and fiber reinforced concrete slabs were considered. 50 mm (.195 in) thick slabs of size 1000 mm square (1.549 in square) clamped on all four edges were tes... |
Imaging systems can become measurement limited under various conditions resulting in strict limits to the amount of acquired image information. For example, a high-speed imager is limited in the number of measurements that can be acquired per second. Similarly, an ultra-small imager such as a micro-endoscope is limited... |
This paper proposes a system called "RerankEverything", which enables users to rerank search results in any search service, such as a Web search engine, an e-commerce site, a hotel reservation site, and so on. This system helps users explore diverse search results. In conventional search services, interactions between ... |
Hepatotoxicity accounts for the limited use of Tamoxifen (TAM) for breast cancer. Herein we investigated if Thymoquinone (TQ) can abate TAM induced toxicity. Our data suggests that TQ co-treatment prevented the extensive weight loss in TAM treated female SD rats with DMBA induced mammary tumors. Moreover, TQ effectivel... |
The emergence of surface mount technology devices has resulted in several important advantages including increased component density and size reduction on the printed circuit board, on the expense of quality inspection. Classical visual inspection techniques require time-consuming image processing to improve the accura... |
Glycosylation of the mu-opioid receptor may play an important role on its function. Using nested PCR, N53Q mutation was prepared in the N-terminal region of the rat mu-opioid receptor cDNA and cloned into the pcDNA3 vector. The plasmids containing the wild-type and mutated receptor cDNA were transfected into the COS-7 ... |
could not countenance the lynching of African Americans, G. Stanley Hall, by stressing the need for engagement with the primitive, hastened the advance of the " masculine primitive " idea of white male power. Theodore Roosevelt embodied both a "civilised manliness" and "primitive masculinity" that enhanced a new "colle... |
The kinetics of symplastic transport in staminal hairs of Setcreasea purpurea was studied. The tip cell of a staminal hair was microinjected with carboxyfluorescein (CF) and the symplastic transport of this CF was videotaped and the digital data analyzed to produce kinetic curves. Using a finite difference equation for... |
This paper deals with the problem of finding the robust fuzzy controller to achieve the robust stability with guaranteed cost for a class of uncertain time-delay systems. Based on the Takagi-Sugeno fuzzy model, the robust stability condition is derived to ensure the robust quadratic stability of the system by applying ... |
Herein, we present the case of a 66-year-old man with an inflammatory myofibroblastic tumour. An inflammatory myofibroblastic tumour is an extremely rare entity, with only 60 cases having been reported to date in the literature. The origin of this type of tumour is unknown and the treatment of choice is surgical resect... |
Abstract This present paper deals with an inventory model with two parameter Weibull deterioration and trapezoidal type demand rate when production and demand are time dependent. Two different EOQ, namely, (i) shortages are not allowed and (ii) shortages are allowed has been considered here. The practical execution of ... |
It is known that protective effects of adaptation to intermittent hypoxia are mediated partly by stimulating of some mitochondrial and microsomal enzymes activity. Our objective was to investigate whether exogenous NO (L-arginine) or NO blocker (L-NNA) modulate mitochondrial and microsomal oxidation during acute hypoxi... |
A 28-year-old man was admitted to the first medical center of Chinese People's Liberation Army General Hospital because of multiple myalgia and intramuscular nodules for more than 2 months. The patient complained of dysphagia, fever and weight loss 2 months ago. Magnetic resonance imaging and biopsy revealed nodular fa... |
The Drosophila ventral neuroectoderm produces a stereotyped array of central nervous system precursors, called neuroblasts. Each neuroblast has a unique identity based on its position, pattern of gene expression and cell lineage. To understand how neuronal diversity is generated, we need to learn how neuroblast-specifi... |
Abstract While both the media and the academic literature focus primarily on male fans, in particular on violence and the prevention of hooliganism, little is known about female football supporters. This is also true of Denmark, a country that is known for its high degree of gender equality. This article aims to give i... |
Iterative source-channel decoding (ISCD) improves the error robustness of a digital communication system by iteratively evaluating natural residual source redundancy and artificial channel coding redundancy in a TURBO-like process. Based on recent results to extrinsic information transfer (EXIT) charts we present a nov... |
To determine the outcomes of percutaneous transluminal angioplasty (PTCA) in patients with subclinical hypothyroidism and to compare them with those in euthyroid patients, we studied retrospectively 48 hypothyroid (4 overtly and 44 subclinically hypothyroid) and 122 euthyroid patients who had a PTCA in Boston's Beth Is... |
ABSTRACT Rotational limb deformity due to tibiotarsal rotation can affect captive-bred houbara bustard chicks (Chlamydotis macqueenii) from an early age. If not completely corrected, the affected birds can neither be released into the wild nor used in captive-breeding projects. A nonsurgical orthopedic method was devel... |
In this work we report the improvement of signal-to-noise ratio in photoplethysmographic images by using a linear polarized filtered light source and the capture of the corresponding scene through a linear polarized analyzer; we also discuss the impact of its use in non-contact reflection photoplethysmographic setups. ... |
In 1976 Jackiw and Rebbi found 1/2 of a fermion number by using Dirac equation. Schrieffer, in several proposals made an effort to suggest that there is a fractional charge. The calculations of Peierls distortion, Berry’s phase and classical action were presented to accomodate the fractional charge in non-relativistic ... |
Abstract Until recently, when sprayed concrete was accelerated by silicates, whether non-reinforced or reinforced by welded mesh, it was logically considered as unsuitable in the long term and only used for temporary support behind a cast-in-place concrete lining. The introduction of polyvinyl chloride (PVC) sheets to ... |
This study had two objectives: (1) to estimate the prevalence of preventable emergency department (ED) visits during the 2016–2020 time period among those living in 19 large urban centers in Alberta and Ontario, Canada, and (2) to assess if the definition of preventable ED visits matters in estimating the prevalence.Pr... |
BackgroundHCV-infection is the main cause of chronic liver disease among Egyptians, the most commonly infected population with HCV genotype 4. The great risk of exposure to infection of health care workers(HCWs) has highlighted the urgent need for implementing an infection control program. Therefore,healthcare workers ... |
Hydrated alkali metal ion-phenol complexes were studied to model these species in aqueous solution for M=Na and K. IR predissociation spectroscopy in the O-H stretch region was used to analyze the structures of M+(Phenol)(H2O)n cluster ions, for n = 1-4. The onset of hydrogen bonding was observed to occur at n=4. Ab in... |
In February 1897, Dr. Aaron McDuffie Moore was either invited or applied to become the superintendent of the Eastern Hospital for the Insane in Goldsboro, N.C. The hospital was a state-funded Black hospital established in 1880. Around the same time, Moore and John Merrick began a campaign of social pressure, fundraisin... |
A 37-year-old man presented with a progressively pruritic and pustular eruption on the face of 2 weeks’ duration. Twenty days prior to the rash onset, he began treatment for scalp psoriasis with a mixture of salicylic acid 20 mg/mL and betamethasone dipropionate 0.5 mg/mL, which inadvertently extended to the facial are... |
In this work we investigate the Z b ( 10610 ) (called simply Z b ) abundance in the hot hadron gas produced in heavy ion collisions after the quark–gluon plasma phase. We use effective Lagrangians to calculate the thermally averaged cross sections of Z b production in processes such as B ( ∗ ) + ¯ B ( ∗ ) → π + Z b ( 1... |
Cultural affiliation has been identified as an important factor in maintaining mental health (Dean, 1977; Garrison, 1978; Westermeyer. 1973; Allison, 1%8; Jilek, 1974). Its role in alcoholism is not known, however. On one hand it might be argued that, since ethnic origin is a major etiologic factor in alcoholism, great... |
Unmanned aerial vehicles (UAVs) are gaining in popularity across a broad spectrum of applications and fields. Two of the main challenges faced when developing autonomous, multi-agent UAV systems is the software development and simulation cycle and the flight test cycle. Each of these aspects can be time consuming and i... |
Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are components of bacterial membranes in terrestrial soils, which are widely used in paleoenvironmental reconstruction in global terrestrial soils and marine sediments. In marine sediments, the mixed sources of brGDGTs complicate the applications of brGDGT-relate... |
We propose a simple yet effective norm-based joint transmit and receive antenna selection (NBJTRAS) assisted and two-tier channel estimation (TTCE) aided space-time shift keying (STSK) system, which is capable of significantly outperforming the conventional STSK system, while efficiently utilising available radio frequ... |
Biomimic nanozymes coassembled by peptides or proteins and small active molecules provide an effective strategy to design attractive nanozymes. Although some promising nanozymes have been reported, rational regulation for higher catalytic activity of biomimic nanozymes remains challenging. Hence, we proposed a novel bi... |
We construct a classical dynamical system whose phase space is a certain infinite-dimensional Grassmannian manifold, and propose that it is equivalent to the large N limit of two-dimensional QCD with an O(2N+1) gauge group. In this theory, we find that baryon number is a topological quantity that is conserved only modu... |
In patients with pathological findings in tests of liver function, ischemic hepatitis is an important differential diagnosis. This condition is most often seen in patients with coronary heart disease. Acute circulatory failure may induce reduced liver perfusion with extreme elevation in transaminase levels within three... |
We evaluated the Singapore Ministry of Health's sentinel surveillance system for influenza virus, which included the monitoring of virological samples from patients with influenza-like illness seen at government primary care clinics and private general practitoner clinics in 2011-12. Using a systematic approach, we ana... |
Stress cardiomyopathy is an acute transient left ventricular dysfunction, associated with emotional stress. In the course of alcohol withdrawal abnormalities of perfusion and myocardial contractility have been described, manifested in the scintigraphic study, with the absence of changes in ECG and echocardiography and ... |
1 The Whole Meaning of a Book of Nonsense: Reading Wittgenstein’s Tractatus Wittgenstein’s Tractatus Logico-Philosophicus, a monograph of less than 100 pages, has perhaps generated the highest ratio of commentary and controversy to text of any philosophical book of the past century. Wittgenstein recognized the difficul... |
Tocotrienols are farnesylated benzopyran natural products that exhibit hypocholesterolemic activity in vitro and in vivo. The mechanism of their hypolipidemic action involves posttranscriptional suppression of HMG-CoA reductase by a process distinct from other known inhibitors of cholesterol biosynthesis. An efficient ... |
Precise measurements of the [sup 3]He melting pressure in several magnetic fields have been made through the various magnetic ordering transitions. Throughout the low-field phase, we find a [ital T][sup 4] temperature dependence of the melting pressure, characteristic of antiferromagnetic spin waves with linear dispers... |
BACKGROUND |
Serum uric acid (UA), the final product of purine degradation, has been proposed to be a marker for the severity and a possible predictor of mortality in patients with pulmonary arterial hypertension (PAH). The objectives of this study were to elucidate whether serum UA level correlates with the clinical features and t... |
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