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BACKGROUND |
Matrix metalloproteinase 10 (MMP10) plays an important role in ischemic stroke and has a close relationship with some stroke risk factors. The aim of this study was to investigate the relationship between two single nucleotide polymorphisms (SNP) in the exon regions of the MMP10 gene and atherothrombotic cerebral infar... |
METHODS |
Five hundred and thirty-seven hospital-based patients who had suffered first atherothrombotic cerebral infarction and 580 unrelated healthy controls were enrolled. Demographic and clinical features of the subjects were recorded, and two polymorphisms, rs17435959 (G>C), rs17293607 (C>T) were chosen to be genotyped by re... |
RESULTS |
There were several clinical parameters, such as blood pressure, fasting blood glucose, total cholesterol, homocysteine, as well as carotid plaque and smoking, but not average age and sex ratios that showed significant differences between patients and control subjects. For rs17435959, there was no significant difference... |
CONCLUSIONS |
These findings suggest that the rs17435959 SNP may not associated with atherothrombotic cerebral infarction risk. We also found that rs17293607 is not polymorphic in our study population.The Durability of Presidential and Parliament-Based Dictatorships |
Many scholars have examined the durability of parliamentary versus presidential regimes in democracies, but the process by which authoritarian leaders are (nominally) elected is generally assumed to be irrelevant. However, even if the electoral outcome is not in doubt, the executive selection process may affect outcome... |
This study was conducted in the Qinghai-Tibet Plateau which is a typical less-favored ecologically fragile area. First, we constructed a GIS-based spatial gridding structure over the study area, the Yarlung Zangbo river basin in China’s Tibet, and used a value-assessment model to measure supply, support, regulation, an... |
In vitro, ex vivo, and in vivo studies were performed to investigate the effect of mixing upon the mechanical properties of a two-component tissue adhesive. The hypothesis investigated was that a more complete mixing of the two components would yield an increase in the mechanical performance of the adhesive. This in tu... |
There has been a lot of attention recently on space inflatable deployment structures. One of the challenges is to control the dynamic properties of the structures during the inflation and deployment. Inflatable tubes used to deploy and support space structures are a key component for many space inflatable structures. I... |
Since 1990 the commodification of popular sport has occurred at a remarkable rate. Although this process has been apparent since pastimes such as 'folk football' were formally codified as 'sports' in the 18th and 19th centuries, in recent times we have witnessed a qualitatively different kind of entry of market-centred... |
The business characteristics in the construction environment has changed considerably over the previous 2 years because of rapid changes in info and construction technology, changes in market conditions, improved consumer needs (i.e. fast response, lower fees, greater customization etc.), item proliferation with uncert... |
An autosomal dominant retinal degeneration, called Rd4, was found in a stock carrying the inversion In(4)56Rk, which was induced in a DBA/2J male. The inversion encompasses nearly all of Chromosome 4. It is homozygous lethal and in heterozygotes is always associated with retinal degeneration. In affected mice, the reti... |
The aim of this study was to evaluate the effect of follicular fluid collected from bovine dominant follicles (bFF) on the in vitro development of goat preantral follicles and determine the best time to add this supplement to the culture medium. The preantral follicles were isolated and randomly distributed into four t... |
The metropolitan Seattle area has utilized a centralized transfusion service model throughout the modern era of blood banking. This approach has used four laboratories to serve over 20 hospitals and clinics, providing greater capabilities for all at a lower consumption of resources than if each depended on its own labo... |
Abstract Multimodality, the study of the interaction of language with other semiotic resources such as images and sound resources, has significant implications for computer assisted language learning (CALL) with regards to understanding the impact of digital environments on language teaching and learning. In this paper... |
The study included 1124 hospitalized patients with COVID-19, who were divided into 2 groups: those who received antifungal agents (main); not receiving them (control). Within the groups, 2 subgroups were distinguished depending on the outcome of treatment: survivors and deceased. According to our results, triazoles (56... |
MAPS (Multimodal Application for the Perception of Spaces) is a tablet App, with associated hardware, for providing on-the-go access to audio-tactile maps of unfamiliar indoor venues to individuals who are blind or visually impaired. Performance of the system was assessed using a survey knowledge task in which particip... |
From days 4–104 of pregnancy, adolescent sheep, weighing 43·7 (SE 0·87)kg were offered a complete diet at two different intakes (approximately 5 or 15 kg/week) designed to meet slightly, or well above, maternal maintenance requirements. The fetal and maternal muscles were taken on day 104 of pregnancy and analysed for ... |
Dual-polarization multi-band orthogonal frequency-division multiplexing (DP-MB-OFDM) signals are optimized at data rates up to 500 Gb/s in dispersion compensation fiber (DCF)-free long-haul links. We compare different polarization crosstalk compensation techniques and explore the DP-MB-OFDM transmission distance limita... |
Aortic valve calcification (AVC) is correlated with atherosclerotic risk factors; however, its significance remains largely unknown. The aim of this study was to investigate whether AVC detected by transthoracic echocardiography can be a useful marker for the identification of significant coronary artery disease (CAD),... |
A 67-year-old woman with a history of bilateral progressive knee pain and swelling was referred for 99mTc-methyl diphosphonate bone scintigraphy. Flow and blood pool images showed bilateral heterogeneous increased uptake and delayed phase revealed mass-looking lobulated heterogeneous increased activity in both of knees... |
The introduction of antibiotics for the chemotherapy of bacterial infections has been one of the most important medical achievements of the past 50 years. However, the emergence of bacterial resistance to antibiotics undermines the therapeutic utility of existing agents, creating a requirement for the discovery of new ... |
AIMS |
Midazolam is the drug of choice for palliative sedation and is titrated to achieve the desired level of sedation. Because of large inter-individual variability (IIV), however, the time it takes to achieve adequate sedation varies widely. It would therefore greatly improve clinical care if an individualized dose could b... |
METHODS |
Using nonlinear mixed effects modelling (NONMEM 7.2), a population pharmacokinetic analysis was conducted with 192 samples from 45 terminally ill patients who received midazolam either orally or subcutaneously. The covariates analysed were patient characteristics, co-medication and blood chemistry levels. |
RESULTS |
The data were accurately described by a one compartment model for midazolam, 1-OH-M and 1-OH-MG. The population mean estimates for midazolam, 1-OH-M and 1-OH-MG clearance were 8.4 l h-1 (RSE 9%, IIV 49%), 45.4 l h-1 (RSE 12%, IIV 60.5%) and 5.1 l h-1 (RSE 11%, IIV 49.9%), respectively. 1-OH-MG clearance was correlated ... |
CONCLUSION |
Our study indicates albumin levels and eGFR as relevant clinical parameters to optimize midazolam dosing in terminally ill patients. The correlation between low albumin levels and decreased midazolam clearance is probably a result of inflammatory response as high CRP levels were correlated in a similar way.Calcium Dist... |
The embryo sac (ES) of Plumbago zeylanica, unlike most other flowering plants, lacks synergidsthe cell type that usually receives the pollen tube and the male gametes. Normally, synergids store copious amounts of calcium, estimated to exceed 15% by weight; this is believed to attract pollen tubes, which penetrate the E... |
Cathelicidins constitute potent antimicrobial peptides characterized by a high cationic charge that enables strong interactions with nucleic acids. In fact, the only human cathelicidin LL-37 triggers rapid sensing of nucleic acids by plasmacytoid dendritic cells (pDC). Among the porcine cathelicidins, phylogenetic anal... |
This book can be presented in two different ways; introducing a particular methodology to build adaptive Web sites and; presenting the main concepts behind Web mining and then applying them to adaptive Web sites. In this case, adaptive Web sites is the case study to exemplify the tools introduced in the text. The autho... |
The technological and social shifts of the past several decades have brought about new modes of learning, participation and civic engagement. As young people work, play and socialize in online spaces, the academic community is exploring the challenges and possibilities of education in the digital age. New definitions o... |
In the scope of the Challenge on Context-aware Movie Recommendation (CAMRa2010), context can mean temporal context (Task 1), mood (Task 2), or social context (Task 3). We suggest to use Pairwise Interaction Tensor Factorization (PITF), a method used for personalized tag recommendation, to model the temporal (week) cont... |
ABSTRACT In 1996, the U.S. Environmental Protection Agency (USEPA) developed the Adult Lead Methodology (ALM) to provide an interim approach to assessing risks from non-residential exposures to lead. Because such exposures often involve occupational activities of adults, the ALM was directed at assessing soil-related l... |
Adiponectin was discovered in 1995 by Phillip Scherer’s research group and described as a novel serum protein similar to C1q, being produced exclusively in adipocytes.1 Adiponectin represents an anti-inflammatory, anti-diabetic and anti-fibrotic adipokine that is highly abundant in human plasma. Adiponectin is induced ... |
Obesity can be regarded as a chronic and low-grade state of inflammation8 and the interpretation of the role of the adipose tissue has developed from a simple energy store to a highly active endocrine,9 inflammatory5 and immunological4 organ. In the context of obesity, the adipose tissue undergoes an inflammatory trans... |
In eight of nine trials spanning 5 yr, relative yield of semidwarf hard red spring wheat (yield expressed as a percent of estimated weed-free yield) decreased linearly as Canada thistle shoot density increased when measured in late July to early August in the northern Great Plains. Differences between yield loss assess... |
Inherent failure mechanisms at elevated temperature are primarily wedge crack growth at triple junctions arising from differential grain boundary (GB) sliding at higher stresses and pore formation on sliding boundaries due to vacancy diffusion at lower stresses and higher T. The behaviours of these mechanisms have been... |
When the ts‐1 mutant of Semliki Forest virus (SFV) was grown in chick embryo or BHK 21 cells at the restrictive temperature (39 degrees C), its membrane glycoproteins were arrested in the endoplasmic reticulum, but started to migrate to the cell surface once the cultures were shifted to the permissive temperature (28 d... |
The purpose of this work is to increase the accuracy, quality and information content of geodetic surveys of vertical steel tanks by using modern geodetic equipment and creating algorithms for data processing of these observations. Method. In order to increase the information content of data for straightening, it is pr... |
This paper aims to present a novel approach to map analysis, treating all ‘map-like’ drawings as icono-texts, according to premises postulated in modern cartographical theory by Brian Harley and his successors in this field. It is not just ‘deconstructing’ which takes place, but further interpretations are stimulated b... |
In a world of pathogens, the ability to detect an incipient infection and to respond rapidly and appropriately to it, is a decisive part of our survival strategy. The innate immune system provides the first response to an infection by initiating an inflammatory response. The monocyte surface of the molecule CD14 is a k... |
The paper brings together three technologies-knowledge based systems, viewpoints and the World Wide Web-to produce a system which delivers advice either directly to a user or through an intermediary (such as a telephone operator). Furthermore, that advice can be tailored to groups of users and to the delivery medium. F... |
PURPOSE: To describe the management and six-year follow-up of a patient who suffered trauma in primary dentition and, as a consequence, presented root malformation in permanent tooth. CASE DESCRIPTION: A 5-years-old boy sustained trauma in primary maxillary anterior teeth due to a bicycle fall. As consequence of avulsi... |
A case of Frey syndrome (FS) secondary to submaxillar gland exeresis is presented and the results of the treatment with botulinum toxin (BTX) type A. FS is a condition of sweating cheek and preauricular area during realtime as a sequel detected in about 20-60% of patients after parotidectomy. The clinical symptoms incl... |
In this paper, some application examples of energy saving measures in two representative Japanese railway companies, mainly in d.c. electric traction power supply system, are introduced. The effect of electric energy storage systems installed to substations is mentioned especially. In addition, it is also described abo... |
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