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RESULTS AND DISCUSSION |
Nine cases with bi-allelic mutations and three cases with mono-allelic mutations were detected in 12 out of 50 patients (24%). The homozygous mutation c.35delG was identified as the cause of hearing loss in six participants (12%). The mutation c.506G>A was identified in three affected individuals (6%). The allelic freq... |
CONCLUSION |
The c.35delG mutation of the GJB2 gene is the most frequently seen causative mutation in the UAE and is followed by the p.Cys169Tyr mutation.Immediate and long-term results of percutaneous mitral commissurotomy: up to 15 years. |
PURPOSE |
To evaluate immediate and long-term clinical results of percutaneous mitral commissurotomy (PMC) in patients with severe mitral stenosis. |
METHODS |
In a retrospective study, data were included from 317 patients over 18 years of age (mean age 45) who had been treated for mitral stenosis between January 1993 and March 2015 with PMC using the Inoue balloon technique. Immediate results: Valvular function improved as evidenced by an increase in mitral valve area from 1... |
CONCLUSIONS |
PMC using the Inoue balloon technique improves morbidity and long-term mortality rates in patients with severe mitral stenosis. Lower Wilkins score and NYHA class at baseline were not found to be significant predictors of mortality in older patients (age > 45). Overall, 65 (61.9%) had survived at 5-15 years follow-up w... |
This paper proposes an accurate part-of-speech (POS) tagging method for Web search queries using the sentence level morphological analysis results of a large-scale Web corpus. POS tagging is a fundamental technique for analyzing queries; however, the existing NLP tools often fail to correctly identify POS tags because ... |
Realizing the organic connection between small farmers and modern agriculture is the first problem in the process of agricultural modernization in Chengdu. From the perspective of the construction of living service system, this paper proposes that to realize the organic connection between the development of small farme... |
Progress in microelectrode-based technologies has facilitated the development of sophisticated methods for manipulating and separating cells, bacteria, and other bioparticles. For many of these various applications, the theoretical modeling of the electrical response of compartmentalized particles to an external field ... |
A fully CMOS transmitter including a power amplifier (PA) using a Cartesian Feedback (CFB) technique is presented. This system aims at improving the linearity of the transmitter, designed in 65nm CMOS technology from STMicroelectronics, essentially the power amplifier linearity. This transmitter delivers a maximum outp... |
Enantiomerically pure thiahelicenes displaying a terminal phosphole unit and a stereogenic phosphorus center have been prepared by oxidative photocyclization of a diaryl-olefin precursor. Starting from one of these phosphathiahelicene oxides, the corresponding trivalent phosphine-Au(I) complex is obtained with complete... |
The energies of the gauche and anti conformers of 2-fluoroethylamine, 2-fluoroethanol and their protonated analogues are calculated using density functional theory. Unlike the non protonated systems, the protonated systems show a strong gauche effect where the C-F and the C-(+)NH(3) or C-F and C-(+)OH(2) bonds are gauc... |
My research interests and experiences focus on applied and computational mathematics, with a particular emphasis on numerical partial differential equations (PDEs), numerical optimization and optimal control of PDEs, and numerical linear algebra. Nowadays, the methodology of mathematical modeling with computer simulati... |
Currently, borreliosis is the most common tick-borne infectious disease in Europe and the USA. In Europe, three species of Borrelia are known to be pathogenic for humans, each of which apparently give rise to different clinical symptoms. Diagnosis is based in particular on the clinical presentation and history of expos... |
The National Institute on Drug Abuse (NIDA) was formed in September, 1973 from a Division of the National Institute on Mental Health (NIMH), from the three-decade old Addiction Research Center (ARC) in Lexington Kentucky, and from the two year old Special Action Office for Drug Abuse Prevention (SAODAP), the original W... |
Regeneration requires the production of large numbers of new cells, and thus cell division regulators, particularly ERK signaling, are critical in regulating this process. In the highly regenerative planarian flatworm, questions remain as to whether ERK signaling controls overall regeneration or plays a head-specific r... |
The use of formal specifications seems to be a silver bullet in a world where technical systems become more and more software intensive and where quality considerations become increasingly important. However, formal methods and the use of formal specifications are by far not so widespread as they should and could be. T... |
Although many elderly people live for years in nursing homes, death certificates routinely obliterate nursing home residence. Data gathered from records of one proprietary nursing home show that of 128 residents, from 45 percent to 66 percent could be classified as “permanent,” depending on the definition. Nevertheless... |
It took only a few short years for Dogma 95 to go from an artistic battle cry to no more than a "commercial gimmick, a PR stunt," a mere device concocted by filmmakers trying to turn the adversity of working in a small country, in Danish, and with limited budgets into an advantage of sorts (Vinterberg, par. 5). No doub... |
Thirty-six neonates were randomly assigned to 2 groups of 18 neonates each. In the pacifier group, infants were given a pacifier before milk feeding. Newborns in the control group were fed without preprandial use of a pacifier. Doppler measurement of peak systolic velocity, enddiastolic velocity, and Pourcelot resistan... |
The authors report a case of transitional cell carcinoma of the left ureteral stump in a 66-year old man treated by nephrectomy for pyonephrosis 6 years previously and cystoprostatectomy for bladder tumour 13 years previously. In the light of this case and based on a review of the literature, they essentially discuss t... |
This study has been performed to confirm the potential of dehydroglyasperin C isolated from licorice to induce phase 2 detoxifying (antioxidant) enzymes using cultured cell and mouse model systems. Dehydroglyasperin C caused a dose‐dependent induction of QR enzyme activity in hepa1c1c7 mouse hepatoma cells and its muta... |
The problem of multilayer mirrors which are capable of reflecting x-ray radiation at two given wavelengths is discussed. Three kinds of two-period multilayers are considered and a comparison of their properties in the soft x-ray region is presented. The scheme of a soft x-ray scanning microscope based on a Schwarzschil... |
The identification of specific amino acid residues involved in protein-protein interaction is fundamental to understanding structure-function relationships. Supported by mathematical calculations, we designed a high-density mutagenesis procedure for the generation of a mutant library of which a limited number of random... |
BACKGROUND |
Vitamin A is necessary for normal lung growth and the ongoing integrity of respiratory tract epithelial cells. Preterm infants have low vitamin A status at birth and this has been associated with increased risk of developing chronic lung disease. Several studies have been undertaken to assess whether vitamin A suppleme... |
OBJECTIVES |
To assess the benefit of supplementation with vitamin A in very low birthweight infants. |
SEARCH STRATEGY |
Searches were made of the Oxford Database of Perinatal Trials, MEDLINE up to June 2002, Cochrane Controlled Trials Register (The Cochrane Library, Issue 2, 2002), and Science Citation Index. The reference lists of relevant trials, recent issues of paediatric and nutrition journals, abstracts and proceedings from releva... |
SELECTION CRITERIA |
Randomised controlled trials which compared the effects of supplemental vitamin A with standard vitamin A regimes in infants with birthweight </=1500g, and which reported clinical outcomes (death, chronic lung disease or bronchopulmonary dysplasia) and/or vitamin A concentrations were considered for the review. |
DATA COLLECTION AND ANALYSIS |
Data on mortality, requirement for supplemental oxygen at one month of age and at 36 weeks post-menstrual age, retinopathy of prematurity and nosocomial sepsis were excerpted by both reviewers independently. Data analysis was conducted according to the standards of the Cochrane Neonatal Review Group. |
MAIN RESULTS |
Seven eligible trials were identified, one having a much larger sample size than the others combined. The meta-analysis suggests supplementation with vitamin A results in benefit in terms of reducing death or oxygen requirement at one month of age [summary RR 0.93 (0.88, 0.99), RD -0.05 (-0.10, -0.01), NNT 20 (10, 100)... |
REVIEWER'S CONCLUSIONS |
Supplementing very low birthweight infants with vitamin A is associated with a reduction in death or oxygen requirement at one month of age, and oxygen requirement amongst survivors at 36 weeks post-menstrual age, with this latter outcome being confined to infants with birthweight less than 1000g. Whether clinicians de... |
e19025 Background: Chronic graft-versus-host disease (cGvHD) remains a significant complication of allogenic hematopoietic stem cell transplantation (allo-HSCT), with an estimated incidence of over 50%. Commonly targeted organs are skin, eyes, mouth, gastrointestinal tract, and liver. Muscular involvement and presentat... |
To compare the responses of two open-pollinated tomato varieties to germination parameters and shoot growth, seeds of open-pollinated tomato varieties, Mersa and Tekeze-1 were given osmopriming treatments with potassium nitrate (KNO3) in a lab setting. A completely randomized design with four replications was used. The... |
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