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Current functional bioinformatics approaches are handicapped by the inability to store functional data at all or by a scattering of data across heterogeneous databases that are difficult to link and query. The Cellular Response Database (CRD) (http://LHI5.umbc.edu/crd) is designed to store and retrieve data concerning ... |
The Remote Associates Test is a creativity test used to assess human participants' ability for association. Small normative datasets of queries exist for this test; however, such datasets do not deal with the issue of potential multiple answers to the same test query. In this work we create a large dataset of queries t... |
Proteins encoded by the epidermal growth factor receptor (EGFR/HER1/ERBB1) gene are being studied as diagnostic, prognostic, and theragnostic biomarkers for numerous human cancers. The clinical application of these tissue/tumor biomarkers has been limited, in part, by discordant results observed for epidermal growth fa... |
JAYKUMAR, NISHITA. M.S., Department of Computer Science and Engineering, Wright State University, 2016. ResQu: A Framework for Automatic Evaluation of Knowledge-Driven Automatic Summarization. Automatic generation of summaries that capture the salient aspects of a search resultset (i.e., automatic summarization) has be... |
Synopsis Twenty-five schizophrenic patients currently experiencing Schneiderian symptoms performed a series of tasks in which drawings had to be made in the absence of immediate visual feedback. In comparison to 10 normal controls and to 30 patients not experiencing Schneiderian symptoms, the target group had great dif... |
ABSTRACT In this article, we explore and identify the varied roles that have been assigned over time to the master reading teacher at the secondary level. Despite the fact that there are fewer master reading teachers (MRTs) at the secondary level, they are often required to take on even more responsibilities than MRTs ... |
Abstract The present study was designed to establish the cellular localization and expression of transforming growth factor β (TGFβ) signaling pathway components, including TGFβ1 and β2; TGFβ receptors type I (TβRI) and II (TβRII); and Smads 2, 3, 4, and 6 during gonadotropin-induced follicular maturation and ovulation... |
One of the main challenges in Tokomak fusion reactor is the design of the breeding blanket since it is the first wall to the plasma. It can be seriously damaged due to the high heat flux and particle impact. However, liquid blankets could be a perfect solution to resist structural damage on the breeding blankets. On th... |
This study offers a powerful blow by blow analysis of the attempts to create peace in BiH since the Dayton Agreement. According to Christopher Bennett, Dayton provided a “balance of terror,” was full of unrealistic deadlines, and aimed at providing internationals with an exit strategy (81) and international involvement... |
Among the various ecological factors influencing the phytonematode fauna the types of plant and soil determine the nematode range. Radopbolus similis, Helicotylencbus multicinctus, Hemicriconemoides strictatbecatus, Ditylencbus augustus, Tylencbulus semipenetrans, and possibly Paratropburus kenanae are examples of high... |
Nowadays hybrid structures composed of concrete and steel are widely constructed in Japan and known to be superior against earthquakes and to be cost effective. In this study, a bridge of 340m in length which crosses a valley was used as a model object, in which the hybrid cable-stayed bridge of two grders was proposed... |
Importance |
Two randomized clinical trials of transcatheter edge-to-edge mitral valve repair in patients with secondary mitral regurgitation (the Multicentre Randomized Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation [MITRA-FR] and the Cardiovascular Outcomes Assess... |
Observations |
In this analysis of the differences in the clinical outcomes of the MITRA-FR and COAPT clinical trials, the ratio of the EROA to the end-diastolic volume in the COAPT study was found to be twice that of the MITRA-FR study (0.002 cm-1 vs 0.001 cm-1, respectively). The finding of a larger proportional EROA in the COAPT s... |
Conclusions and Relevance |
The results of proportionality analyses based on EROA differ from those based on a volume analysis. This disparity casts doubt on the notion that an EROA analysis alone can explain the different results of the 2 randomized clinical trials.Modified Space Vector Modulated Three-phase to Three-phase Matrix Converter Under... |
This paper presents a study of modified space vector modulation technique (MSVM) for matrix converter (MC) which produces balanced output voltages in presence of unbalanced supply voltage conditions. The conventional modulation techniques derived for balanced supply conditions give poor performance in presence of abnor... |
Wincenty Lutoslawski (1863–1954) was internationally recognized in the academic world as a prominent Plato scholar. His fragmentary correspondence with Bertrand Russell is presented in this paper. Before World War II he initiated an exchange of letters with Russell on issues such as reincarnation, but the replies he re... |
To keep up with malware writers, software producers in both the commercial and open-source software worlds have adopted various automatic software update mechanisms. Some of these mechanisms distribute updates after requesting a user's permission; others install updates automatically. Although such systems provide some... |
This paper describes a TCP splitting solution for multi-access bent-pipe GEO satellite networks. Such networks have a star topology with a large number of user terminals connected to a hub over a satellite link with broadcast downlink and multi-access uplink. In such systems, besides improving the end-to-end performanc... |
Keloids are an exuberant response to cutaneous wound healing, characterized by an exaggerated synthesis of collagen probably due to the increase of fibroblasts activity and their proliferation rate. Currently, there are not definitive treatments or pharmacological therapies able to prevent keloid formation and its recu... |
Just over a decade ago, it was established that NK cells in the thymus do not follow precisely the same developmental pathway as conventional NK cells that develop in the bone marrow. Subsequently, it has emerged that NK cells are one branch of a family of innate lymphoid cells (ILCs). ILC1s and thymic NK cells have, h... |
The effect of leaf desiccation on the photosynthetic activities in vivo was probed by the photoacoustic method. The aim of this research was: (a) To study the photoacoustic signal per se in varied conditions in order to develop this tool as a probe for stress conditions in vivo. (b) To obtain results pertaining to elec... |
Service oriented programming - which combines distributed object computing, component-based and Web-based concepts - has recently emerged as a promising approach to develop dynamic and heterogeneous service provision environments. Such systems are referenced in literature as service oriented architectures. Classic stra... |
This chapters examines the phenomenon of organized crime in the South, focusing on Phenix City, Alabama, which became notorious for its high concentration of gambling dens, illegal bars, and prostitution rings. It draws attention to the story of Albert Patterson, a local attorney who fought the government corruption th... |
With the digitalization of industry and society, data centers have grown into an essential key strategic infrastructure, centralizing the processing, storage and distribution of vast amounts of information. Through continuing centralization, their size grows ever larger, while at the same time they need to remain flexi... |
Mandibular bone compactness has been studied by ultrasonic osteometry before and after implantation. Ultrasonic examinations were carried out in remote periods after orthodontic treatment (implantations) of patients with dentition defects. Analysis of the results indicates that 2-4 years after the implantation is the c... |
An on-line multidimensional supercritical fluid extraction/microcolumn liquid chromatography/capillary gas chromatography system (SFE/LC/GC) has been developed and applied to the quantitative determination of trace levels (parts per billion) of chlorpyrifos insecticide in grass field samples. This system provides all t... |
In order to study the variation of vortices and heat transfer enhancement |
characteristics of piezoelectric vibrating cantilever in liquid-cooled |
channels, the effects of fluid density and viscosity, mainstream velocity |
and excitation voltage on vortices were analyzed. The theoretical and |
numerical simulation of piezoelectric vortices was carried out by using |
fluid-solid coupling method. On the basis of hydrodynamic function |
considering the additional effect of liquid viscosity and density on |
piezoelectric vibrator, the vortex structure of piezoelectric vibrator was |
analyzed by panel method free-wake model. It is found that the larger the |
density of the liquid, the smaller the vortex shedding strength and the |
radius of the core; the larger the viscosity of the liquid, the easier to |
fully develop the vortex generated by the excitation; the increase of the |
mainstream flow velocity is beneficial to the development of the vortex |
structure and the increase of the vorticity intensity; compared with the |
increase of the mainstream flow velocity, the excitation voltage is more |
conducive to the enhancement of the vorticity structure, then make it easier |
to mix hot and cold fluids, thus enhancing heat transfer.Effective supply of eco-product and its influence factors at provincial scale of China from the perspective of supply-side reform. |
Eco-product is scarce product with consequences on human health, economy and society all over the world. In order to understand the effective supply of eco-product and figure out its law of scale efficiency, panel data from 2004 to 2015 with labor force, capital, resource, and energy source was carefully selected as th... |
ABSTRACT Background: Schizophrenia affects approximately 10% of the world’s population. Early detection of schizophrenia may significantly delay its progression. Although sensory gating deficits are reported in schizophrenia, it remains challenging how sensory gating deficits can be used with other metrics for risk det... |
A monoclonal antibody (mAb) was produced against immunoglobulin M (IgM) of South American camelids. A single radial immunodiffusion (SRID) assay and a competitive enzyme-linked immunosorbent assay (ELISA) were developed to measure IgM in serum samples. Isotype and specificity of the mAb were assessed. The performance o... |
The presence of the phytotoxic sesquiterpene (-)-hamanasic acid A {(-)HAA; 7-carboxy-8-hydroxy-1(2), 12(13)-dien-bisabolene} isolated from Flourensia campestris (FC), was investigated in the South American species of the genus, together with the evaluation of the phytotoxic activity of their leaf aqueous extracts. (-)H... |
BACKGROUND |
Rivastigmine is a cholinesterase inhibitor, approved for the treatment of mild-to-moderate dementia of Alzheimer's type. |
OBJECTIVE |
To explore the efficacy and safety of the maximal tolerated dose of rivastigmine capsules in Chinese patients with mild-to-moderate Alzheimer's disease (AD). |
METHODS |
The study was a multicenter, open-label, single-arm, phase IV clinical study in mild-to-moderate drug-naïve AD patients treated with rivastigmine capsules. The primary endpoint was the changes in the total scores of Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) from baseline to week 16. Secondary e... |
RESULTS |
222 patients were enrolled. Of these, 136 (75.1%) patients received and maintained the effective dose (≥6 mg/d) of rivastigmine for at least 4 weeks. The ADAS-Cog scale score improved in rivastigmine-treated patients at week 16 compared with baseline (p < 0.001) by 2.0 (95% CI: -3.0 to -1.1) points, which met the pre-d... |
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