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This study investigates a systematic approach to product design based on artificial intelligence. This investigation proposes the use of artificial intelligence techniques, including fuzzy theory, back propagation neural networks (BPN), and genetic algorithms (GA), along with morphological analysis to synthesize, evalu... |
Recent advances in cell isolation and culture procedures, combined with growing understanding and use of molecular biology and biochemistry techniques, have resulted in the establishment of a new field of biological/biomedical research: cellular and tissue engineering. In the biomaterials field, cell and tissue bioengi... |
The following discussion adds to the discourse regarding the relationship between public administration reform and ethics policies. In this theoretical paper, a narrative is employed that re-reads the old Weberian model as a model of ‘institutional integrity’, which is slowly replaced by a public management concept th... |
The failure damages of granite under cyclic fatigue load were caused by the propagation and coalescent of cracks at mesoscale, so it was helpful to understand the mechanical behaviours of rock by quantitatively investigating on meso-damage of granite. The uniaxial cyclic fatigue tests on granite coming from the ChangJi... |
Ethernet passive optical network (EPON) has drawn considerable research attention in recent years. EPON can be implemented in different topologies in access network environment. Recently, the tree topology was the focus of the researchers. In this paper, we propose a cost effective novel ring-based EPON architecture wi... |
In many clinical trials, treatment efficacy is based upon response to a biological marker that is measured repeatedly during the course of follow-up. However, in some of these trials it is not clear, a priori, how treatment effects on the marker may manifest themselves or what kinds of effects are clinically meaningful... |
Abstract Methyl parathion (C8H10NO5PS) is widely used insecticide known to cause fatal intoxication in both human and animals. This study was carried out to investigate the deleterious effects of methyl parathion on small intestine of mice. Animals were injected intraperitoneally an acute dose (3mg/kg bwt) of methyl pa... |
The federated cloud is the future generation of cloud computing, allowing sharing of computing and storage resources, and servicing of user tasks among cloud providers through a centralized control mechanism. However, a great challenge lies in the efficient management of such federated clouds and fair distribution of t... |
This study introduces technology independent sizing for CMOS integrated opamp based on neural networks (NN). The aim is to predict the transistor sizes of integrated opamp that correspond to design constraints, without knowing the SPICE technology parameters. Furthermore, in contrast to other modeling researches, the o... |
Purpose: To investigate PT-112 in a human prostate cancer (PC) cell panel and assess differential sensitivity, cell death mechanism, induction of mitochondrial stress, and release of damage-associated molecular patterns (DAMPs). |
Background: PT-112 is a novel pyrophosphate-platinum conjugate with clinical activity in advanced solid tumors including lung, thymoma and castration-resistant PC, and in multiple myeloma. PT-112’s cancer cell death was shown previously to be independent of DNA damage. In vitro and in vivo mouse experiments have shown... |
Methods: Sensitivity to PT-112 was assessed in human PC cell lines (LNCap, LNCap-C4, LNCap-C4-2, DU-145, 22Rv1, VCap and PC-3) and the non-tumorigenic prostate cell line RWPE-1. We analyzed parameters involved in the cell death process such as apoptotic and necroptotic markers, mitochondrial membrane potential, and mt... |
Results: PT-112 caused growth inhibition and cancer cell death without affecting healthy RWPE-1 cells. The pan-caspase inhibitor Z-VAD-fmk significantly reduced cell death, with more mild effects seen with the RIPK1/2 inhibitor necrostatin-1 in certain cell lines. PT-112-induced cell death was accompanied by a promine... |
Conclusions: PT-112 was broadly active in the PC cell lines tested, while sparing benign prostate cells, indicative of PT-112 cancer cell selectivity and of activity that crosses the varied malignant prostate phenotypes, including androgen receptor positive and negative cell lines. Cell death was primarily apoptotic, ... |
Citation Format: Ruth Soler-Agesta, Tyler D. Ames, Matthew Price, José Jimeno, Christina Y. Yim, Raquel Moreno-Loshuertos, Alberto Anel. PT-112 induces potent mitochondrial stress and immunogenic cell death in human prostate cancer cell lines [abstract]. In: Proceedings of the American Association for Cancer Research ... |
The sensitivity of many biological and chemical sensors is critically dependent on the stability of the potential of the reference electrode being used. The stability of a reference electrode’s potential is highly influenced by the properties of its surface. In this paper, for the first time, the formation of nanosheet... |
NURSING IMPLICATIONS Malnutrition is a common problem for patients waiting for orthotopic liver transplantation and is a risk factor for posttransplantation morbidity. Nutritional status can worsen rapidly in the postoperative period because of preoperative malnutrition, the stress of the surgical procedure, immunosupp... |
This paper shows a comparison of the vertical and horizontal tank orientation and the associated maximum demands from synthesized aggregated load models for various grid scenarios. Aggregated load profiles are produced by replicating a 50 litre (50% capacity) draw event for a 100-litre dual-mountable electric water hea... |
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v of 0.80 is determined for a scenario similar to normal grid operation for a peak time window of 4 hours. The significance of this work is to quantify the difference in maximum power demand of a population of EWHs due to tank orientations in a controlled simulated environment.Musings on The Future of International Cr... |
Since time immemorial, war has brought unspeakable misery to millions, yet the vexing problem of enforcing criminal responsibility upon perpetrators of naked aggression and mass violations of human dignity that amount to genocide, war crimes or crimes against humanity, has been addressed only recently. Rules governing ... |
This essay explores how an old snapshot of a group of friends perpetuates an idealised version of their childhood. When presented with the photograph during interview sessions, individuals expressed a longing for a racially integrated past. Posed together, seemingly relaxed and genuinely familiar with each other, the g... |
Significance Drug delivery systems with electrochemical actuation offer programmable volume/flowrates in miniaturized form factors for in vivo pharmacological experiments in freely moving animals where flowrate control and delivery time are important. Here, we present an analytical model that accounts for all the probl... |
Several nitrobenzyl-based photosensitive phosphoramide mustards were synthesized. The nitrobenzyl moiety was structurally varied to find the most promising prodrug candidates in respect to photorelease and activity of the alkylating species. The synthesis of these compounds proved to be applicable even in regard to com... |
This article presents the Ritz method for the vibration analysis of sandwich plates having an orthotropic core and laminated facings. The planform of the plate may take on any arbitrary shape. On the basis of the Mindlin plate theory and the Ritz method, the governing eigenvalue equation for determining the natural fre... |
Adult rats born in hypoxia but raised in air are more reactive to acute hypoxic challenges. The relation between perfusion pressure and perfusion flow (P/Q plot) was analyzed in the preparation of ventilated perfused lungs isolated from 3 groups of adult rats. Control animals of the first group were born and lived in a... |
Identifying stakeholder beliefs and attitudes is critical for resolving management conflicts. Debate over outdoor cat management is often described as a conflict between two groups, environmental advocates and animal welfare advocates, but little is known about the variables predicting differences among these critical ... |
The increasing popularity of WiFi brings new challenges in the design of wireless protocols but at the same time creates exciting opportunities for novel ways of exploiting WiFi technology in a variety of applications. On one hand, the smaller form factor of today's WiFi devices allows WiFi users to access wireless net... |
"Modification versus Complementation in the Structure of English Noun Phrases. Apart from its head, the core element around which all the other phrasal constituents cluster, the noun phrase may contain dependent elements effecting determination (which poses few taxonomical issues), modification or complementation (two ... |
Keywords: complementation, modification, premodifier, postmodifier, complement, the noun phrase |
"Model Analysis and Computer Simulation Study for Feeders of the High-Speed Package Sorter |
In this paper, the working process of package feeders in high-speed package sorter is discussed. By applying appropriate simplifications, feeder mathematic model is created. Then by doing the simulation and analysis, it is discovered that a sorter should companion with multi feeders; and that buffer- stage should be eq... |
The Secondary Marketing Research Certificate (SMRC) is a collaboration among the University of Texas at San Antonio Libraries, College of Business Administration, and marketing faculty inspired by the Business Research Essentials program at Goizueta Business Library. Students in junior-level marketing research courses ... |
Formic acid is the toxic metabolite responsible for the retinal and optic nerve toxicity produced in methanol intoxication. Previous studies in our laboratory have documented formate-induced retinal dysfunction and histopathology in a rodent model of methanol intoxication. The present studies define the time and concen... |
Phyllanthus niruri, a typical member of family Euphorbiaceae, is a small annual herb found throughout the tropical and subtropical regions of both hemispheres. The genus Phyllanthus has been used in traditional medicine for its wide range of pharmacological activities like antimicrobial, antioxidant, anticancer, antiin... |
As it appears from the paper by Lichtenstein et al. [1] in this issue of the Journal, the Swedish Twin Registry (STR) is a unique resource for clinical, epidemiological and genetic studies. It has already been heavily exploited and yielded numerous valuable contributions, but the resource is far from being exhausted. T... |
Mobile Ad Hoc networks (MANETs) are gaining increased interest due to their wide range of potential applications in civilian and military sectors. The self-control, self-organization, topology dynamism, and bandwidth limitation of the wireless communication channel make implementation of MANETs a challenging task. Vehi... |
To significantly enhance the spectral efficiency of the MBS service, UEP and MIMO are important core technologies to realize such challenging goal. Taking into account of the implementation constraints, 4 times 2 is widely accepted as a reasonable MIMO setup and is a mandatory configuration of the next generation wirel... |
There is a major problem in connection with the wrath of Poseidon in Homer's Odyssey. We are told by Homer and Zeus (Od. 1.20-1, 1.68-75) that Poseidon raged continually against the hero from the time that the Cyclops was blinded until Odysseus reached Ithaca; and, when back on Ithaca the man complains to Athena about ... |
In vivo magnetic resonance imaging was used to study the effect of ancrod (CAS 9046-56-4, Arwin), a plasma fibrinogen level lowering agent, on brain lesion in two rat models of acute focal cerebral ischaemia. Total lesion volume was determined by multislice T2-weighted magnetic resonance imaging 24 h after permanent mi... |
Relevance. Odontogenic infection is one of the most important problems of dental science. The variety of anti-inflammatory oral hygiene products determines the need for targeted selection of preventive toothpastes and rinses, balms, foams, elixirs, as well as monitoring and training the algorithm of hygienic measures f... |
The human glycoprotein IIB (GPIIB) gene is expressed only in megakaryocytes, and its promoter displays cell type specificity. We show that this specificity involved two cis-acting sequences. The first one, located at -55, contains a GATA binding site. Point mutations that abolish protein binding on this site decrease t... |
We present a fully conservative, high-resolution, finite volume algorithm for advection-diffusion equations in irregular geometries. The algorithm uses a Cartesian grid in which some cells are cut by the embedded boundary. A novel feature is the use of a “capacity function” to model the fact that some cells are only pa... |
War is human, but the conduct of war has to be made humane. This is one major purpose of the Law of War. The idea of 'tempera', as propounded by Grotius, is about attempts at mitigating the plights of human beings during wars. jus ad bellum may hav~ become, at least at the level of formulation of law, a thing of the pa... |
Fusion of immune spleen cells of mice immunized with CEA with a mouse myeloma cell line resulted in several hybrid cell lines secreting antibodies to CEA as tested by radio-immunoassay. Four of these were cloned by limiting dilution and large amounts of anti-CEA antibodies were produced by growing the anti-CEA-producin... |
We estimate the response of domestic oil drilling to uncertainty about oil prices. We measure domestic drilling activity by the weekly number of rigs drilling for oil, and we measure oil uncertainty by implied volatility from options on oil futures. We find that oil uncertainty has a negative and significant effect on ... |
Let k>2 and k be a k-element set. We show that though the partial clone I:=/spl cap//sub a/spl isin/k/pPol {a} of all idempotent partial operations on k is contained in finitely many partial clones on k, it is quite hard to determine the number of all partial clones on k containing the partial clone I on k. Indeed this... |
Water channel aquaporin 5 (AQP5) is highly expressed at the apical membrane of alveolar type I epithelial cells and confers high osmotic water permeability. AQP5 is also expressed in lung cancer tissue. Previous studies showed there was an up‐regulation of AQP5 expression in cancer tissue compared to surrounding normal... |
Donor deoxyribonucleic acid strands in the eclipse phase of genetic transformation of pnuemococcus (Streptococcus pneumoniae) are purified as a complex with a cf the deoxyribonucleic acid strand in this complex to digestion by nucleases was shown to be 50- to 1,000-fold less than that of uncomplexed single strands of d... |
The mango (Mangifer indica L.) is an important species of the family Anacardiaceae and is one of the most important crops cultivated commercially in many parts of the world. Hence, a better understanding of the phylogeny in this species is crucial as it is the basis knowledge of improving its genetic resources which is... |
Developed countries are facing a sustained increase in life expectancy. Elderly people represent the fastest growing portion of cardiovascular patients. However, nonagenarians with ST-segment elevation myocardial infarction (STEMI) are often underrepresented in clinical trials as prolonged follow-up may be compromised... |
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