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Quantitation of therapeutic monoclonal antibodies (mAb) using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for pharmacokinetic (PK) studies is becoming an essential complement to traditional antibody-based ligand binding assays (LBA). Here we show an automated method to perform LC-MS/MS-based quantitation,... |
Here, a novel anticancer gene therapy with a bacterial tRNase gene, colicin D or virulence associated protein C (VapC), is suggested using biodegradable polymeric nanoparticles, such as poly(β‐amino esters) (PBAEs) as carriers. These genes are meticulously selected, aiming at inhibiting translation in the recipients by... |
A large animal model of fulminant hepatic necrosis is necessary to test the efficacy of artificial liver support systems. A recent model was developed using D‐galactosamine in anesthetized dogs. Because of the difficulties encountered with prolonged anesthesia, a similar protocol was used in 10 unanesthetized dogs. Int... |
Background: Cardiac hemosiderosis in major thalassemia has a high mortality rate. Serum ferritin levels are routinely performed to measure body iron deposit Early detection of cardiac dysfunction by routine echocardiography is very important to prevent complications due to hemosiderosis. Objective: To analyze correlati... |
the recent publication by Pirgozliev et al. (2022) entitled ‘Feeding guanidinoacetic acid to broiler chickens can compensate for low dietary metabolizable energy formulation’ which I believe it contains serious flaws related to misinterpretation of results. This paper contains a biased conclusion about the effects of g... |
Thyroid weight, thyroidal radioiodide uptake, and cyclic AMP-dependent protein kinase activity of a thyroid supernatant fraction were increased significantly in spontaneously hypertensive rats (SHR), apparently because of increased secretion of pituitary TSH. However, the thyroids of SHR did not make supernormal amount... |
This paper presents four posterior, interhemispheric cerebral cysts found at perinatal autopsy. All cysts appeared to attenuate the overlying posterior corpus callosum. All had a base over the roof of the third ventricle and midbrain with a lining that resembled tela choroidea with the choroid plexus tufts projecting i... |
1. The primate orbitofrontal cortex is the site of convergence of information from primary taste and primary olfactory cortical regions. In addition, it receives projections from temporal lobe visual areas concerned with the representation of objects such as foods. Previous work has shown that the responses of gustator... |
Objective—CCN3 belongs to the CCN family, which constitutes multifunctional secreted proteins that act as matrix cellular regulators. We investigated the pathophysiological roles of CCN3 in the vessels. Methods and Results—We examined the effects of CCN3 on the proliferation and migration of rat vascular smooth muscle ... |
Mogamulizumab is a humanized monoclonal antibody against C‐C chemokine receptor 4 approved in the United States for the treatment of patients with relapsed/refractory mycosis fungoides or Sézary syndrome, the most common forms of cutaneous T‐cell lymphoma (CTCL). The exposure‐response relationships for efficacy (progre... |
The physiological reaction of postocclusive local reactive hyperemia is regulated by neurovascular mechanisms and it reflects the function of microcirculation. Thermoregulatory changes occur first, in the form of increased skin surface temperature, which is usually followed by an increase in local blood flow. This stud... |
Abstract Gas hydrate reservoirs are widespread on the world’s continental margins and in the Arctic, but little is known about the way in which they form. We use conservation principles to derive a set of equations that describe hydrate formation in uniform porous media. Using scaling arguments, we identify the physica... |
ABSTRACT This paper discusses offensive behaviors that often occur in groups. The sources and meanings of such behavior both to the individual and the group are explored. Principles are presented to help workers decide when to respond to the more serious underlying personal and group issues these behaviors may express,... |
BACKGROUND |
The symptom severity of back pain/leg pain is not correlated with the severity of degenerative changes and canal stenosis in lumbar stenosis. Considering the individual pain sensitivity might play an important role in pain perception, this discordance between the radiologic findings and clinical symptoms in degenerativ... |
OBJECTIVE |
To determine the relationship among the clinical symptoms, radiologic findings, and the individual pain sensitivity in the patients with degenerative lumbar spinal stenosis. |
STUDY DESIGN |
Retrospective analysis of prospectively collected data. |
SETTING |
A spine center in the department of orthopedic surgery. |
METHODS |
In 94 patients who had chronic back pain and/or leg pain caused by degenerative lumbar spinal stenosis, a medical history, a physical examination, and completion of a series of questionnaires, including pain sensitivity questionnaire (PSQ) [total PSQ and PSQ-minor], Oswestry Disability Index (ODI), Visual Analog Pain S... |
RESULTS |
Total PSQ and PSQ-minor were not dependent on the grade of canal stenosis after gender adjustment. VAS for leg pain and back pain was highly associated with the total PSQ and the PSQ-minor. Total PSQ and PSQ-minor were also significantly associated with ODI. Among SF-36 scales, the PSQ minor had significant correlation... |
LIMITATIONS |
The multiple lesions of canal stenosis and/or disc degeneration and the grade of facet degeneration were not considered as a variable. |
CONCLUSION |
The current study suggests that the pain sensitivity could be a determining factor for symptom severity in the degenerative spinal disease.Narrowing the meaning of ‘deprivation’ under the property clause? A critical analysis of the implications of the Constitutional Court’s Diamond Producers judgment for constitutional... |
Abstract Section 25(1) of the Constitution provides that no one may be deprived of property except in terms of law of general application, which law may not permit arbitrary deprivation. Consequently, there must be a deprivation before a property holder will qualify for protection under this provision. The meaning of t... |
ABSTRACT Objective: To examine the factor structure of the Inventory of Parent Accommodations of Children’s Symptoms (IPACS) among a community sample of healthy children. Method: An online survey was completed by 220 parents ages 18-65 (M = 34.49; 96% female) for a study examining the effects of parent behaviors on fre... |
Performance monitoring enables the rapid detection of mismatches between goals or intentions and actions, as well as subsequent behavioral adjustment by means of enhanced attention control. These processes are not encapsulated, but they are readily influenced by affective or motivational variables, including negative a... |
The idea and issue of planetary protection was first raised in the late 1950s and officially was taken up by the Committee on Space Research (COSPAR) in the early 60s. Planetary protection is, according to the NASA office, is the “practice of protecting solar system bodies (i.e., planets, moons, comets, and asteroids) ... |
BACKGROUND |
Rising environmental concerns and recent global scenario of cleaner production and consumption are leading to the design of green industrial processes to produce alternative fuels and chemicals. Although bioethanol is one of the most promising and eco-friendly alternatives to fossil fuels yet its production from food a... |
OBJECTIVE |
The main objective of this study was to present the noteworthy potentialities of lignocellulosic biomass as an enormous and renewable biological resource. The particular focus was also given on engineering ligninolytic consortium for bioconversion of lignocelluloses to ethanol and chemicals on sustainable and environme... |
METHODS |
Herein, an effort has been made to extensively review, analyze and compile salient information related to the topic of interest. Several authentic bibliographic databases including PubMed, Scopus, Elsevier, Springer, Bentham Science and other scientific databases were searched with utmost care, and inclusion/ exclusion... |
RESULTS |
Bioethanol production from lignocellulosic biomass can largely satisfy the possible inconsistency of first-generation ethanol since it utilizes inedible lignocellulosic feedstocks, primarily sourced from agriculture and forestry wastes. Two major polysaccharides in lignocellulosic biomass namely, cellulose and hemicell... |
CONCLUSION |
In conclusion, given the present unpredicted scenario of energy and fuel crisis accompanied by global warming, lignocellulosic bioethanol holds great promise as an alternative to petroleum. Apart from bioethanol, the simultaneous production of other value-added products may improve the economics of lignocellulosic bioe... |
Background: Assessment of cell proliferation through the evaluation of cyclin D1, AgNORs, and DNA content provides a promising approach to the prognosis of breast cancer. Therefore, this work aimed to evaluate the prognostic significance of AgNORs and DNA image cytometry, and their relation to cyclin D1 immunoreactivit... |
The paper investigates the limits of applicability of the critical energy release rate for predicting the growth of a crack in nanoscale materials applying the strain gradient elasticity theory (SGET) capable to capture size effects, nonlocal material point interactions and surface effects in the form of (phenomenologi... |
Organs, cells and microstructures in cells dealt with in biomedical image analysis are volumetric data. We are required to process and analyse these data as volumetric data without embedding into higher-dimensional vector space from the viewpoints of object oriented data analysis. Sampled values of volumetric data are ... |
This report is on the consumer health website, MedlinePlus. This website was created by the National Library of Medicine and features content produced by the National Institutes of Health. This report covers an overview, origin, content and possible future evolution of this website. The report also spotlights the speci... |
In this paper, Family Life Event Questionnaire and Children Behavior Questionnaire were applied to measure the 402 subjects between 3-15 years old from 301 rural and urban families. The results showed that family life events were accompanied with behavior problems in children. Six events, which can be concluded into th... |
Aiming at the design of highly brilliant NIR emissive optical probes, e.g., for in vivo near-infrared fluorescence imaging (NIRF), we studied the absorption and fluorescence properties of the asymmetric cyanines Dy678, Dy681, Dy682, and Dy676 conjugated to the model antibody IgG. The ultimate goal was here to derive ge... |
This paper introduces a rescue robot to extract a casualty from hazardous environment and suggests a specific whole-body behavior strategy suitable for the rescue mission taking into account the characteristics of the robot configuration. Since the robot has redundant degrees of freedom, a task-priority based CLIK as d... |
The previously reported simplified cylindrical linear cloak is improved so that the cloak's outer surface is impedance-matched to free space. The scattering characteristics of the improved linear cloak is compared to the previous counterpart as well as the recently proposed simplified quadratic cloak derived from quadr... |
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