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a6f07aad-d8d3-4020-9b2f-574c49834601
10.1097/HJH.0b013e328334c126
# Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the $677 \mathrm{C} \rightarrow \mathrm{T}$ polymorphism in MTHFR Geraldine Horigana, Helene McNultya, Mary Warda, J.J. Straina, John Purvisb and John M. Scottc Objective The purpose was to examine the effect of intervention with r...
Systolic blood pressure
Low risk of bias
No information about allocation concealment, but a statement that the study is randomised. We judged that the allocation sequence was probably concealed until participants were enrolled and assigned to the intervention. There was no information on baseline differences between the groups – a table of baseline characteri...
High risk of bias
Excluded 18 participants from the analyses after randomisation (including 2 outliers).
High risk of bias
BP data was presented for 179 of 197 participants (91%). Data excluded from 2 participants because their values for BP were outliers. Data also excluded from 16 other paritipcnats for a variety of resaons, the most common being 'not contactable or withdrew voluntaryily' (n=7).
Low risk of bias
BP measured in standard way (two separate measurements taken 15 min apart with patient at rest). Outcome assessor was blinded to intervention status.
Some concerns
No information about whether data were analysed in accordance with a pre-specified analysis plan that was finalised before unblinded outcome data were available.
High risk of bias
b4f4d777-2b63-4252-a76f-40fbf01244da
10.1212/wnl.50.2.466
# Effectiveness of high-dose riboflavin in migraine prophylaxis A randomized controlled trial J. Schoenen, MD, PhD; J. Jacquy, MD; and M. Lenaerts, MD Article abstract—A deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis. We found in a previous open study that high-dose riboflavin wa...
Adverse events
Low risk of bias
The allocation sequence was concealed and known only to the pharmacist who prepared the study material.
Low risk of bias
Participants and investigators were blinded and there was no apparent deviations from the intended intervention.
Low risk of bias
5 people were excluded from the analysis after randomisation out of 55 people randomised.
Low risk of bias
Investigators were blinded to intervention status.
Some concerns
No information about whether data were analysed in accordance with a pre-specified analysis plan that was finalised before unblinded outcome data were available.
Some concerns
3ce32920-d4f7-4b67-84ef-50330dedd6e8
10.1093/eurheartj/ehz745.0428
P3566 # Ambulatory blood pressure response to riboflavin supplementation in adults with the C677T polymorphism in the folate metabolising enzyme methylenetetrahydrofolate reductase (MTHFR) M. Ward<sup>1</sup>, C.F. Hughes<sup>1</sup>, A. Mc Mahon<sup>1</sup>, M. Rooney<sup>1</sup>, J.J. Strain<sup>1</sup>, R. Plumb<s...
Systolic blood pressure
High risk of bias
No information about allocation concealment, but a statement that the study is randomised. Large imbalances in sex and moderate differences in BP that were very unlikely to be due to chance, and most likely because only the results from participants with SBP of 125 mmHg or more at baseline were presented.
High risk of bias
Analyses excluded eligible participants who had baseline SBP under 125 mmHg.
High risk of bias
No outcome data was presented for participants who had baseline SBP under 125 mmHg.
Low risk of bias
Trial registry information describes the trial as double-blind (participants and investigators blinded).
High risk of bias
The results from only a subset of participants are presented, which suggests the numerical result may have been selected on the basis of multiple analyses of the data.
High risk of bias
c1f1f0d8-6e51-4e6d-a36f-a470162f4522
10.1161/HYPERTENSIONAHA.111.01047
# Stratified Treatment of Hypertension # Blood Pressure in Treated Hypertensive Individuals With the MTHFR 677TT Genotype Is Responsive to Intervention With Riboflavin Findings of a Targeted Randomized Trial Carol P. Wilson, Helene McNulty, Mary Ward, J.J. Strain, Tom G. Trouton, Birgit A. Hoeft, Peter Weber, Franz F...
Systolic blood pressure
Low risk of bias
No information about allocation concealment, but a statement that the study is randomised. We judged that the allocation sequence was probably concealed until participants were enrolled and assigned to the intervention. There are some differences in baseline characteristics between group, although none are statisticall...
High risk of bias
4 outliers were removed for BP.
High risk of bias
There were 3 drop outs. In addition data from 4 participants was excluded because their values for BP were outliers.
Low risk of bias
Outcome assessor was blinded to intervention status.
Some concerns
No information about whether data were analysed in accordance with a pre-specified analysis plan that was finalised before unblinded outcome data were available.
High risk of bias
2ac14668-0317-41e4-b567-daebbd19a146
10.1097/HJH.0b013e328334c126
# Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the $677 \mathrm{C} \rightarrow \mathrm{T}$ polymorphism in MTHFR Geraldine Horigana, Helene McNultya, Mary Warda, J.J. Straina, John Purvisb and John M. Scottc Objective The purpose was to examine the effect of intervention with r...
Diastolic blood pressure
Low risk of bias
No information about allocation concealment, but a statement that the study is randomised. We judged that the allocation sequence was probably concealed until participants were enrolled and assigned to the intervention. There was no information on baseline differences between the groups – a table of baseline characteri...
High risk of bias
Excluded 18 participants from the analyses after randomisation (including 2 outliers).
High risk of bias
BP data was presented for 179 of 197 participants (91%). Data excluded from 2 participants because their values were outliers. Data excluded from 16 other participants for a variety of reasons, the most common being 'not contactable or withdrew voluntarily' (n=7).
Low risk of bias
BP measured in standard way (two separate measurements taken 15 min apart with patient at rest). Outcome assessor was blinded to intervention status.
Some concerns
No information about whether data were analysed in accordance with a pre-specified analysis plan that was finalised before unblinded outcome data were available.
High risk of bias
6b06eef4-8524-4b97-b1b6-416d9ef15b9b
10.1161/HYPERTENSIONAHA.111.01047
# Stratified Treatment of Hypertension # Blood Pressure in Treated Hypertensive Individuals With the MTHFR 677TT Genotype Is Responsive to Intervention With Riboflavin Findings of a Targeted Randomized Trial Carol P. Wilson, Helene McNulty, Mary Ward, J.J. Strain, Tom G. Trouton, Birgit A. Hoeft, Peter Weber, Franz F...
Diastolic blood pressure
Low risk of bias
No information about allocation concealment, but a statement that the study is randomised. We judged that the allocation sequence was probably concealed until participants were enrolled and assigned to the intervention. There are some differences in baseline characteristics between group, although none are statisticall...
High risk of bias
4 outliers were removed for DBP.
High risk of bias
There were 3 drop outs and 4 outliers excluded out of 91 randomised.
Low risk of bias
Outcome assessor was blinded to intervention status.
Some concerns
No information about whether data were analysed in accordance with a pre-specified analysis plan that was finalised before unblinded outcome data were available.
High risk of bias
831f1327-9019-4db6-b625-26231f7c5533
10.1016/j.healun.2010.11.009
"# Tadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hy(...TRUNCATED)
clinical worsening
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
36979232-c25d-43e2-ac00-1a5f7d99677c
10.1016/j.healun.2010.11.009
"# Tadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hy(...TRUNCATED)
clinical worsening
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
dc00bdfa-bfd9-4c1f-a981-72237fcf5730
10.1016/j.healun.2010.11.009
"# Tadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hy(...TRUNCATED)
clinical worsening
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
d1cae5ac-c6d1-4dfe-bdc9-29c93bc7d775
10.1016/j.healun.2010.11.009
"# Tadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hy(...TRUNCATED)
Death
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
null
Low risk of bias
End of preview. Expand in Data Studio

LogiMed-RoB Dataset

LogiMed-RoB accompanies the paper “Can LLMs Follow Medical Expert Logic? A Benchmark for Hierarchical Logical Consistency in Risk-of-Bias Assessment.” It evaluates whether large language models follow the hierarchical expert logic used in clinical Risk-of-Bias (RoB) assessment, rather than merely matching final labels.

The release contains 860 randomized controlled trials (RCTs) and 14,820 structured queries across two complementary tracks. Gold-standard labels originate from expert assessments in Cochrane systematic reviews, peer-reviewed publications, ROBIN, and RoBBR. No AI-generated pseudo-labels are used.

Dataset configurations

Configuration Standard RCTs Items Structured queries Sources
track_a Cochrane RoB 2.0 201 626 13,772 Cochrane (467), Figshare (159)
track_b Cochrane RoB 1.0 659 1,048 1,048 ROBIN (713), RoBBR (335)

Track A contains 22 rule-based signaling queries per assessment. Track B contains one evidential-faithfulness query per item.

Files

File Description
RCT_ROB2_final_dataset.json Track A: RoB 2.0 outcome-level assessments with full RCT text, outcome descriptions, domain judgments, expert rationales, and overall risk labels.
ssr_dataset_merged.json Track B: RoB 1.0 evaluation items with signaling questions, expert labels, evidence windows, answers, and rationales.

Both files are UTF-8 JSON arrays and are exposed as a test split because LogiMed-RoB is an evaluation benchmark rather than a training corpus.

Loading the dataset

from datasets import load_dataset

track_a = load_dataset(
    "BUPT-Reasoning-Lab/LogiMed-RoB",
    "track_a",
    split="test",
)

track_b = load_dataset(
    "BUPT-Reasoning-Lab/LogiMed-RoB",
    "track_b",
    split="test",
)

Download the complete repository with the Hugging Face CLI:

hf download BUPT-Reasoning-Lab/LogiMed-RoB \
  --repo-type dataset \
  --local-dir ./LogiMed-RoB

Data format

Track A: RCT_ROB2_final_dataset.json

Each entry contains the following fields:

{
  "id": "<uuid>",
  "study": "<study identifier>",
  "full_paper": "<Markdown text of the RCT paper>",
  "outcome": "<target outcome>",
  "randomisation_process_judgment": "<risk label>",
  "randomisation_process_reasoning": "<expert rationale>",
  "intended_interventions_judgment": "<risk label>",
  "intended_interventions_reasoning": "<expert rationale>",
  "missing_outcome_data_judgment": "<risk label>",
  "missing_outcome_data_reasoning": "<expert rationale>",
  "measurement_outcome_judgment": "<risk label>",
  "measurement_outcome_reasoning": "<expert rationale>",
  "selection_reported_result_judgment": "<risk label>",
  "selection_reported_result_reasoning": "<expert rationale>",
  "overall_risk": "<risk label>"
}

The RoB 2.0 domains are:

  1. Bias arising from the randomisation process.
  2. Bias due to deviations from intended interventions.
  3. Bias due to missing outcome data.
  4. Bias in measurement of the outcome.
  5. Bias in selection of the reported result.

Track B: ssr_dataset_merged.json

Each entry contains the following fields:

{
  "id": "<uuid>",
  "study": "<study identifier>",
  "bias": "<bias domain>",
  "question": "<signaling question>",
  "label": "low | high | unclear",
  "context_list": ["<evidence sentence>", "..."],
  "answers": [
    {
      "answer": "yes | no | unclear",
      "reason": "<expert rationale>"
    }
  ]
}

Quality assurance

  • Track A: all 626 items were manually extracted and calibrated against published expert conclusions; 467 are allocated to Cochrane and 159 to Figshare.
  • Track B: approximately 20% of the release (210 items) was independently re-verified by medical annotators, with 93.5% agreement on evidence-window accuracy.
  • No AI-generated pseudo-labels are included in either track.

Responsible use and source terms

LogiMed-RoB is intended for research on model evaluation, evidence-based medicine, and clinical reasoning. It must not be used as an autonomous clinical decision-making system.

The release incorporates material derived from Cochrane Library, Figshare, ROBIN, and RoBBR. Use and redistribution of individual records remain subject to the terms of their original sources; therefore the dataset card uses the Hugging Face other license designation. Consult the source projects and accompanying paper for provenance details.

Project resources

Citation

@misc{huang2026logimedrob,
  title  = {Can LLMs Follow Medical Expert Logic? A Benchmark for Hierarchical Logical Consistency in Risk-of-Bias Assessment},
  author = {Huang, Jiayu and Tang, Zichen and Ling, Qianhui and Kuang, Zemin and E, Haihong},
  year   = {2026},
  url    = {https://github.com/BUPT-Reasoning-Lab/LogiMed-RoB}
}
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