"""
MEXAR - PubMed Central OA fetcher for the medical corpus.

Pulls ~220 documents from PubMed Central Open Access across three medical
subdomains (cardiology, oncology, internal medicine), parses the full-text XML
into plain text, and writes one .txt file per document into
test_data/medical_real/, along with a manifest.json for auditing.

Usage:
    python backend/scripts/fetch_pubmed.py

Requirements:
    pip install requests lxml

Environment:
    NCBI_EMAIL  — your email address (required by NCBI usage policy)
    NCBI_API_KEY — optional; raises rate limit from 3 req/sec to 10 req/sec

Run this locally (not in a network-restricted sandbox).
"""
import argparse
import json
import logging
import os
import sys
import time
from pathlib import Path
from typing import Dict, List, Optional

import requests
from dotenv import load_dotenv
load_dotenv()

try:
    from lxml import etree
except ImportError:
    sys.exit(
        "lxml is required — run: pip install lxml"
    )

# ---------------------------------------------------------------------------
# Configuration
# ---------------------------------------------------------------------------

logging.basicConfig(
    level=logging.INFO,
    format="%(asctime)s [%(levelname)s] %(message)s",
)
logger = logging.getLogger(__name__)

# NCBI email is mandatory per NCBI E-utilities usage policy.
# Override with the NCBI_EMAIL environment variable or the --email CLI flag.
DEFAULT_NCBI_EMAIL: str = os.getenv("NCBI_EMAIL", "your_email@example.com")
NCBI_API_KEY: Optional[str] = os.getenv("NCBI_API_KEY")  # optional; raises rate cap to 10/s

REPO_ROOT = Path(__file__).resolve().parent.parent.parent
OUTPUT_DIR = REPO_ROOT / "test_data" / "medical_real"

# Three subdomains × 75 docs ≈ 220 total (some may fail or be empty).
SEARCH_TERMS: Dict[str, str] = {
    "cardiology": "cardiology AND open access[filter]",
    "oncology": "oncology AND open access[filter]",
    "internal_medicine": "internal medicine AND open access[filter]",
}
DOCS_PER_SUBDOMAIN: int = 75

# NCBI rate limits: 3 req/sec without key, 10/sec with key.
REQUEST_DELAY_NO_KEY: float = 0.35   # ≈ 2.9 req/sec — safe without key
REQUEST_DELAY_WITH_KEY: float = 0.12  # ≈ 8.3 req/sec — safe with key

NCBI_BASE = "https://eutils.ncbi.nlm.nih.gov/entrez/eutils"

# ---------------------------------------------------------------------------
# NCBI E-utilities helpers
# ---------------------------------------------------------------------------


def _ncbi_params(extra: dict, email: str) -> dict:
    """Return base params dict merged with extra, including optional API key."""
    params = {"email": email, **extra}
    if NCBI_API_KEY:
        params["api_key"] = NCBI_API_KEY
    return params


def esearch(term: str, retmax: int, email: str) -> List[str]:
    """
    Run an E-search against the PMC database and return a list of PMC IDs.

    Args:
        term:   NCBI search query string.
        retmax: Maximum number of IDs to retrieve.
        email:  Requester email (required by NCBI).

    Returns:
        List of PMC ID strings (numeric, without the 'PMC' prefix).
    """
    url = f"{NCBI_BASE}/esearch.fcgi"
    params = _ncbi_params(
        {"db": "pmc", "term": term, "retmax": retmax, "retmode": "json"},
        email,
    )
    resp = requests.get(url, params=params, timeout=30)
    resp.raise_for_status()
    return resp.json()["esearchresult"]["idlist"]


def efetch_xml(pmc_id: str, email: str) -> bytes:
    """
    Fetch the full-text XML for a single PMC article.

    Args:
        pmc_id: Numeric PMC ID string (without the 'PMC' prefix).
        email:  Requester email.

    Returns:
        Raw XML bytes from the PMC OA full-text endpoint.
    """
    url = f"{NCBI_BASE}/efetch.fcgi"
    params = _ncbi_params(
        {"db": "pmc", "id": pmc_id, "rettype": "full", "retmode": "xml"},
        email,
    )
    resp = requests.get(url, params=params, timeout=60)
    resp.raise_for_status()
    return resp.content


# ---------------------------------------------------------------------------
# XML → plain-text extraction
# ---------------------------------------------------------------------------

# Tags in the JATS PMC XML that contain useful body text.
_BODY_TAGS = {"abstract", "body", "sec", "p", "title"}


def _iter_text(element) -> str:
    """
    Recursively collect all text inside an lxml element, with
    paragraph-level whitespace to keep the output readable.
    """
    parts = []
    if element.text:
        parts.append(element.text.strip())
    for child in element:
        child_text = _iter_text(child)
        if child_text:
            # Add a blank line between sections/paragraphs.
            sep = "\n\n" if child.tag in {"sec", "p", "title", "abstract"} else " "
            parts.append(sep + child_text)
        if child.tail:
            parts.append(child.tail.strip())
    return " ".join(p for p in parts if p)


def xml_to_plain_text(xml_bytes: bytes) -> str:
    """
    Parse PMC full-text XML and extract human-readable plain text.

    Pulls text from <abstract>, <body>, and nested <sec>/<p> elements,
    strips all XML markup, and returns a clean, whitespace-normalised string.

    Args:
        xml_bytes: Raw XML bytes as returned by efetch.

    Returns:
        Plain-text string.  Empty string if parsing fails.
    """
    try:
        root = etree.fromstring(xml_bytes)
    except etree.XMLSyntaxError as exc:
        logger.warning("XML parse error: %s", exc)
        return ""

    sections: List[str] = []
    # Pull <article-title>, <abstract>, and <body> in document order.
    for tag in ("article-title", "abstract", "body"):
        for element in root.iter(tag):
            text = _iter_text(element).strip()
            if text:
                sections.append(text)

    plain = "\n\n".join(sections)
    # Collapse excessive whitespace.
    import re
    plain = re.sub(r" {2,}", " ", plain)
    plain = re.sub(r"\n{3,}", "\n\n", plain)
    return plain.strip()


def _get_article_meta(xml_bytes: bytes) -> Dict[str, str]:
    """Extract title and journal name from parsed PMC XML for the manifest."""
    meta: Dict[str, str] = {"title": "", "journal": ""}
    try:
        root = etree.fromstring(xml_bytes)
        title_el = root.find(".//article-title")
        if title_el is not None:
            meta["title"] = (_iter_text(title_el) or "").strip()
        journal_el = root.find(".//journal-title")
        if journal_el is not None:
            meta["journal"] = (journal_el.text or "").strip()
    except Exception:
        pass
    return meta


# ---------------------------------------------------------------------------
# Main fetch loop
# ---------------------------------------------------------------------------


def fetch_subdomain(
    subdomain: str,
    term: str,
    n: int,
    output_dir: Path,
    email: str,
    delay: float,
) -> List[Dict]:
    """
    Search for and download up to `n` PMC articles matching `term`.

    Args:
        subdomain:  Label string used in the manifest.
        term:       NCBI search query.
        n:          Target number of documents.
        output_dir: Directory to write .txt files into.
        email:      NCBI requester email.
        delay:      Seconds to sleep between requests.

    Returns:
        List of manifest entry dicts for successfully fetched documents.
    """
    logger.info("Subdomain '%s': searching for %d docs …", subdomain, n)
    try:
        ids = esearch(term, n, email)
    except Exception as exc:
        logger.error("esearch failed for '%s': %s", subdomain, exc)
        return []

    logger.info("  Found %d IDs; fetching full text …", len(ids))
    entries: List[Dict] = []

    for pmc_id in ids:
        time.sleep(delay)
        try:
            xml_bytes = efetch_xml(pmc_id, email)
            plain = xml_to_plain_text(xml_bytes)
        except requests.HTTPError as exc:
            logger.warning("HTTP error for PMC%s: %s", pmc_id, exc)
            continue
        except Exception as exc:
            logger.warning("Failed PMC%s: %s", pmc_id, exc)
            continue

        if len(plain) < 200:
            logger.debug("PMC%s: text too short (%d chars), skipping.", pmc_id, len(plain))
            continue

        out_path = output_dir / f"PMC{pmc_id}.txt"
        out_path.write_text(plain, encoding="utf-8")

        meta = _get_article_meta(xml_bytes)
        entries.append(
            {
                "pmc_id": pmc_id,
                "subdomain": subdomain,
                "title": meta["title"],
                "journal": meta["journal"],
                "source_url": f"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC{pmc_id}/",
                "path": str(out_path),
                "char_count": len(plain),
            }
        )
        logger.info("  Saved PMC%s (%d chars)", pmc_id, len(plain))

    logger.info("  Subdomain '%s': %d documents saved.", subdomain, len(entries))
    return entries


def main(email: str = DEFAULT_NCBI_EMAIL, docs_per_subdomain: int = DOCS_PER_SUBDOMAIN) -> None:
    """
    Entry point.  Iterates over all three medical subdomains and writes results.
    """
    if email == "your_email@example.com":
        logger.warning(
            "Using placeholder email — set the NCBI_EMAIL env var or pass --email. "
            "NCBI may throttle requests without a valid email."
        )

    OUTPUT_DIR.mkdir(parents=True, exist_ok=True)

    delay = REQUEST_DELAY_WITH_KEY if NCBI_API_KEY else REQUEST_DELAY_NO_KEY
    manifest: List[Dict] = []

    for subdomain, term in SEARCH_TERMS.items():
        entries = fetch_subdomain(subdomain, term, docs_per_subdomain, OUTPUT_DIR, email, delay)
        manifest.extend(entries)

    manifest_path = OUTPUT_DIR / "manifest.json"
    manifest_path.write_text(json.dumps(manifest, indent=2), encoding="utf-8")
    logger.info(
        "Done.  %d medical documents fetched.  Manifest → %s",
        len(manifest),
        manifest_path,
    )


# ---------------------------------------------------------------------------
# CLI
# ---------------------------------------------------------------------------

if __name__ == "__main__":
    parser = argparse.ArgumentParser(
        description="Fetch PubMed Central OA articles for the MEXAR medical corpus."
    )
    parser.add_argument(
        "--email",
        default=DEFAULT_NCBI_EMAIL,
        help="Your email address (required by NCBI usage policy).",
    )
    parser.add_argument(
        "--docs-per-subdomain",
        type=int,
        default=DOCS_PER_SUBDOMAIN,
        help="Number of documents to fetch per subdomain (default: %(default)s).",
    )
    args = parser.parse_args()
    main(email=args.email, docs_per_subdomain=args.docs_per_subdomain)