leadboard / categories.json
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boards: add proteases, nuclear receptors, epigenetics (8 boards)
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{
"spec": "v1.1",
"categories": [
{
"id": "A",
"name": "ํก์ˆ˜",
"en": "Absorption",
"icon": "๐Ÿซ—",
"desc": "๋จน์€ ์•ฝ์ด ๋ชธ ์•ˆ์œผ๋กœ ๋“ค์–ด์˜ค๋Š”๊ฐ€",
"planned": 8,
"boards": [
"Solubility",
"LogP",
"Caco2"
],
"desc_en": "Whether an orally dosed compound enters the body at all"
},
{
"id": "D",
"name": "๋ถ„ํฌ",
"en": "Distribution",
"icon": "๐Ÿฉธ",
"desc": "ํ˜ˆ์•ก ๋‹จ๋ฐฑ์งˆ์— ๋ถ™๋Š”๊ฐ€ ยท ๋‡Œ๊นŒ์ง€ ๊ฐ€๋Š”๊ฐ€",
"planned": 5,
"boards": [
"PPB",
"Vdss"
],
"desc_en": "Binding to plasma protein; passage across the blood-brain barrier"
},
{
"id": "M",
"name": "๋Œ€์‚ฌ",
"en": "Metabolism",
"icon": "๐Ÿ”ฅ",
"desc": "๊ฐ„์—์„œ ์–ผ๋งˆ๋‚˜ ๋นจ๋ฆฌ ์‚ฌ๋ผ์ง€๋Š”๊ฐ€ ยท ์–ด๋–ค ํšจ์†Œ๊ฐ€ ๊ฑด๋“œ๋ฆฌ๋Š”๊ฐ€",
"planned": 7,
"boards": [
"CYP3A4",
"CYP2D6",
"CYP2C9"
],
"desc_en": "How quickly the liver clears it, and which enzymes act on it"
},
{
"id": "E",
"name": "๋ฐฐ์„ค",
"en": "Excretion",
"icon": "๐Ÿ’ง",
"desc": "๋ชธ ๋ฐ–์œผ๋กœ ์–ธ์ œ ๋‚˜๊ฐ€๋Š”๊ฐ€",
"planned": 2,
"boards": [
"HalfLife"
],
"desc_en": "When the compound leaves the body"
},
{
"id": "T",
"name": "๋…์„ฑ",
"en": "Toxicity",
"icon": "โ˜ ๏ธ",
"desc": "์‹ฌ์žฅ ยท ๊ฐ„ ยท ๋ณ€์ด์›์„ฑ. ์‹ ์•ฝ์ด ๊ฐ€์žฅ ๋งŽ์ด ์ฃฝ๋Š” ์ž๋ฆฌ",
"planned": 7,
"boards": [
"hERG",
"LD50"
],
"desc_en": "Cardiac, hepatic and mutagenic liability โ€” where candidates most often fail"
},
{
"id": "P",
"name": "ํšจ๋Šฅยท์—ญ๊ฐ€",
"en": "Potency",
"icon": "๐ŸŽฏ",
"desc": "ํ‘œ์ ์— ์–ผ๋งˆ๋‚˜ ์„ธ๊ฒŒ ๋ถ™๋Š”๊ฐ€",
"planned": 4,
"boards": [
"AChE",
"MAOB",
"COX2",
"Nav17"
],
"desc_en": "How tightly a compound binds its intended target"
},
{
"id": "Z",
"name": "์—ํ”ผ์ œ๋„คํ‹ฑ",
"en": "Epigenetics",
"icon": "๐Ÿ“–",
"desc": "์œ ์ „์ž๋ฅผ ๋ฐ”๊พธ์ง€ ์•Š๊ณ  ์ฝ๋Š” ๋ฐฉ์‹์„ ๋ฐ”๊พผ๋‹ค",
"desc_en": "Changing how genes are read without changing the genes",
"planned": 5,
"boards": [
"BRD4",
"HDAC1"
]
},
{
"id": "N",
"name": "ํ•ต์ˆ˜์šฉ์ฒด",
"en": "Nuclear receptors",
"icon": "๐Ÿงฟ",
"desc": "ํ˜ธ๋ฅด๋ชฌ ์‹ ํ˜ธ๋ฅผ ๋ฐ›์•„ ์œ ์ „์ž๋ฅผ ์ผœ๊ณ  ๋ˆ๋‹ค โ€” ์œ ๋ฐฉ์•”ยท์ „๋ฆฝ์„ ์•” ํ‘œ์ ",
"desc_en": "Hormone-driven transcription factors โ€” breast and prostate cancer targets",
"planned": 5,
"boards": [
"ERalpha",
"AR"
]
},
{
"id": "E2",
"name": "ํ”„๋กœํ…Œ์•„์ œ",
"en": "Proteases",
"icon": "โœ‚๏ธ",
"desc": "๋‹จ๋ฐฑ์งˆ์„ ์ž๋ฅด๋Š” ํšจ์†Œ โ€” ์•Œ์ธ ํ•˜์ด๋จธยทํ•ญ์‘๊ณ ยทํ•ญ๋ฐ”์ด๋Ÿฌ์Šค๊ฐ€ ์—ฌ๊ธฐ ๊ฑธ๋ฆฐ๋‹ค",
"desc_en": "Protein-cleaving enzymes behind Alzheimer, anticoagulant and antiviral programmes",
"planned": 6,
"boards": [
"BACE1",
"Thrombin",
"FactorXa"
]
},
{
"id": "K",
"name": "ํ‚ค๋‚˜์•„์ œยท์„ ํƒ์„ฑ",
"en": "Kinase & Selectivity",
"icon": "๐Ÿ”‘",
"desc": "ํ‚ค๋‚˜์•„์ œ ์ˆ˜๋ฐฑ ๊ฐœ ์ค‘ ์–ด๋””์— ๋ถ™๊ณ  ์–ด๋””๋Š” ํ”ผํ•˜๋Š”๊ฐ€",
"planned": 13,
"boards": [
"EGFR",
"JAK2",
"PI3Ka",
"FLT3",
"VEGFR2",
"CDK2",
"HER2",
"ABL1",
"BRAF",
"KIT",
"ALK",
"Selectivity"
],
"desc_en": "Which of several hundred kinases are engaged, and which are spared"
},
{
"id": "R",
"name": "์ˆ˜์šฉ์ฒดยทGPCR",
"en": "Receptors & GPCR",
"icon": "๐Ÿ“ก",
"desc": "์„ธํฌ ํ‘œ๋ฉด ์ˆ˜์šฉ์ฒด โ€” ์Šน์ธ์•ฝ ์„ธ ๊ฐœ ์ค‘ ํ•˜๋‚˜๊ฐ€ ์—ฌ๊ธฐ๋ฅผ ๋…ธ๋ฆฐ๋‹ค",
"desc_en": "Cell-surface receptors โ€” the target class behind roughly a third of approved drugs",
"planned": 8,
"boards": [
"D2",
"HT2A",
"MuOpioid",
"KappaOpioid",
"A2A",
"CB1"
]
},
{
"id": "S",
"name": "๊ตฌ์กฐ๊ธฐ๋ฐ˜ ๊ฒฐํ•ฉ",
"en": "Structure-based",
"icon": "๐Ÿงฌ",
"desc": "์–ด๋–ค ์ž์„ธ๋กœ ๋ถ™๋Š”๊ฐ€ ยท ๊ทธ ์ž์„ธ๊ฐ€ ๋ฌผ๋ฆฌ์ ์œผ๋กœ ๋ง์ด ๋˜๋Š”๊ฐ€",
"planned": 4,
"boards": [],
"desc_en": "The binding pose, and whether that pose is physically admissible"
},
{
"id": "X",
"name": "์„ธํฌยทํ‘œํ˜„ํ˜•",
"en": "Cell & Phenomics",
"icon": "๐Ÿ”ฌ",
"desc": "์•ฝ์ด ์‹ค์ œ ์„ธํฌ์— ๋ฌด์Šจ ์ง“์„ ํ•˜๋Š”๊ฐ€",
"planned": 5,
"boards": [
"Phenotype"
],
"desc_en": "What a compound actually does to a living cell"
},
{
"id": "I",
"name": "ํ•ญ๊ฐ์—ผยท์ „์„ธํฌ",
"en": "Anti-infective & whole-cell",
"icon": "๐Ÿฆ ",
"desc": "๊ท ๊ณผ ๊ธฐ์ƒ์ถฉ์ด ์‹ค์ œ๋กœ ์ฃฝ๋Š”๊ฐ€ โ€” ๋‹จ๋ฐฑ์งˆ์ด ์•„๋‹ˆ๋ผ ์ƒ๋ฌผ์„ ์ฝ๋Š”๋‹ค",
"desc_en": "Whether the organism actually dies โ€” the readout is a living cell, not a protein",
"planned": 6,
"boards": [
"Malaria",
"BSubtilis"
]
},
{
"id": "C",
"name": "์ž„์ƒ ์ธ์‹ค๋ฆฌ์ฝ”",
"en": "Clinical in-silico",
"icon": "๐Ÿฅ",
"desc": "์‚ฌ๋žŒ ๋ชธ์—์„œ์˜ ๋†๋„ ยท ์•ฝ๋ฌผ ์ถฉ๋Œ ยท ์šฉ๋Ÿ‰. ๊ฒจ๋ฃฐ ํ‘œ๊ฐ€ ์•„์ง ์—†๋Š” ์ž๋ฆฌ",
"planned": 6,
"boards": [
"Withdrawal"
],
"desc_en": "Human exposure, drug-drug interaction and dose โ€” endpoints with no leaderboard yet"
},
{
"id": "G",
"name": "์ƒ์„ฑยท๋ชจ๋‹ฌ๋ฆฌํ‹ฐ",
"en": "Generation & Modality",
"icon": "โš—๏ธ",
"desc": "์ƒˆ๋กœ ๋งŒ๋“ค์–ด ๋‚ด๋Š” ์ชฝ ยท ์†Œ๋ถ„์ž๋ฅผ ๋„˜์–ด์„œ๋Š” ์ชฝ",
"planned": 5,
"boards": [],
"desc_en": "Generating new matter, and modalities beyond small molecules"
}
]
}