Sync systemsagebrain
Browse files- README.md +38 -0
- config.json +36 -0
- systemsagebrain.pt +3 -0
README.md
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---
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license: bsd-3-clause
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library_name: pyaging
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tags:
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- pyaging
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- aging-clock
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- biology
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- dna-methylation
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---
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# systemsagebrain
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Brain-system component of Systems Age: a whole-blood DNAm score built from brain-system biomarker and functional PCs and mortality training, returned on an age-like scale.
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|---|---|
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| **Predicts** | brain-system biological age |
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| **Species** | Homo sapiens |
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| **Tissue** | whole blood |
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| **Data type** | DNA methylation |
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| **Model type** | PCA + elastic net regression |
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| **Year** | 2025 |
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## Use with pyaging
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```python
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import pyaging as pya
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pya.pred.predict_age(adata, ["systemsagebrain"])
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```
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Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).
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## Citation
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Sehgal, R., Markov, Y., Qin, C., et al. (2025). Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nature Aging, 5, 1880–1896.
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https://doi.org/10.1038/s43587-025-00958-3
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config.json
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{
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"approved_by_author": "\u231b",
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"citation": "Sehgal, R., Markov, Y., Qin, C., et al. (2025). Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nature Aging, 5, 1880\u20131896.",
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"citations": 41,
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"citations_date": "2026-07-05",
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"clock_name": "systemsagebrain",
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"data_type": "DNA methylation",
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"doi": "https://doi.org/10.1038/s43587-025-00958-3",
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"journal": "Nature Aging",
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"last_author": "Morgan Levine",
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"model_type": "PCA + elastic net regression",
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"n_features": 125175,
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"notes": "Brain-system component of Systems Age: a whole-blood DNAm score built from brain-system biomarker and functional PCs and mortality training, returned on an age-like scale.",
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"platform": [
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"Illumina 450K",
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"Illumina EPIC"
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],
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"population": "older adults",
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"predicts": [
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"brain-system biological age"
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],
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"reference_values": true,
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"research_only": true,
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"species": "Homo sapiens",
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"tissue": [
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"whole blood"
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],
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"training_target": [
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"mortality"
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],
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"unit": [
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"years"
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],
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"version": "v0.3.0",
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"year": 2025
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}
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systemsagebrain.pt
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version https://git-lfs.github.com/spec/v1
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oid sha256:c4bf29fd52c5f2b3057b3e0dda42985badcc6b16037b48e5ac1627deebdd6a42
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size 2016708380
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