| { |
| "approved_by_author": "\u231b", |
| "citation": "Tomusiak, A., et al. \u201cDevelopment of an epigenetic clock resistant to changes in immune cell composition.\u201d Communications Biology 7, 934 (2024).", |
| "citations": 53, |
| "citations_date": "2026-07-05", |
| "clock_name": "intrinclock", |
| "data_type": "DNA methylation", |
| "doi": "https://doi.org/10.1038/s42003-024-06609-4", |
| "journal": "Communications Biology", |
| "last_author": "Eric Verdin", |
| "model_type": "two-stage elastic net regression", |
| "n_features": 380, |
| "notes": "Multi-tissue chronological-age clock designed by excluding CpGs associated with CD8+ T-cell differentiation, then fitting two sequential elastic-net models so predictions remain stable across immune-cell composition. The article reports 381 CpGs; the official lambda.min model and this implementation both use the same 380 non-zero CpG inputs.", |
| "platform": [ |
| "Illumina 450K", |
| "Illumina EPIC" |
| ], |
| "population": "all ages", |
| "postprocess": "anti_log_linear", |
| "predicts": [ |
| "chronological age" |
| ], |
| "research_only": null, |
| "species": "Homo sapiens", |
| "tissue": [ |
| "multi-tissue" |
| ], |
| "training_target": [ |
| "chronological age" |
| ], |
| "unit": [ |
| "years" |
| ], |
| "version": "0.5.0", |
| "year": 2024 |
| } |
