{
 "approved_by_author": "\u231b",
 "citation": "Teschendorff, Andrew E. \"A comparison of epigenetic mitotic-like clocks for cancer risk prediction.\" Genome Medicine 12 (2020): 56.",
 "citations": 452,
 "citations_date": "2026-07-05",
 "clock_name": "hypoclock",
 "data_type": "DNA methylation",
 "doi": "https://doi.org/10.1186/s13073-020-00752-3",
 "journal": "Genome Medicine",
 "last_author": "Andrew E. Teschendorff",
 "model_type": "mean aggregation",
 "n_features": 678,
 "notes": "Pyaging returns an inverted HypoClock burden score, 1 minus the mean beta value across 678 solo-WCGW CpGs; higher values therefore indicate deeper PMD hypomethylation. The assigned 2018 paper is the biological precursor, while the named 678-site implementation is from 2020.",
 "platform": [
  "Illumina 450K"
 ],
 "population": "human, age unspecified",
 "postprocess": "one_minus",
 "predicts": [
  "mitotic age"
 ],
 "preprocess": "mean",
 "reference_values": true,
 "research_only": null,
 "species": "Homo sapiens",
 "tissue": [
  "multi-tissue"
 ],
 "training_target": [
  "not applicable"
 ],
 "unit": [
  "beta value"
 ],
 "version": "0.5.0",
 "year": 2020
}