{
 "approved_by_author": "\u231b",
 "citation": "Shireby, G. L., et al. \"Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex.\" Brain 143.12 (2020): 3763-3775.",
 "citations": 206,
 "citations_date": "2026-07-05",
 "clock_name": "corticalclock",
 "data_type": "DNA methylation",
 "doi": "https://doi.org/10.1093/brain/awaa334",
 "journal": "Brain",
 "last_author": "Jonathan Mill",
 "model_type": "elastic net regression",
 "n_features": 347,
 "notes": "Cortex-specific DNA-methylation chronological-age estimator trained by elastic net on 1,047 post-mortem cortical samples; its 347-CpG weighted score is back-transformed to years.",
 "platform": [
  "Illumina 450K"
 ],
 "population": "human, age unspecified",
 "postprocess": "anti_log_linear",
 "predicts": [
  "chronological age"
 ],
 "reference_values": true,
 "research_only": null,
 "species": "Homo sapiens",
 "tissue": [
  "brain cortex"
 ],
 "training_target": [
  "chronological age"
 ],
 "unit": [
  "years"
 ],
 "version": "0.5.0",
 "year": 2020
}