---
license: mit
library_name: pyaging
tags:
- pyaging
- aging-clock
- biology
- dna-methylation
---

# corticalclock

Cortex-specific DNA-methylation chronological-age estimator trained by elastic net on 1,047 post-mortem cortical samples; its 347-CpG weighted score is back-transformed to years.

| | |
|---|---|
| **Predicts** | chronological age |
| **Species** | Homo sapiens |
| **Tissue** | brain cortex |
| **Data type** | DNA methylation |
| **Model type** | elastic net regression |
| **Year** | 2020 |

## Use with pyaging

```python
import pyaging as pya

pya.pred.predict_age(adata, ["corticalclock"])
```

Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).

## Citation

Shireby, G. L., et al. "Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex." Brain 143.12 (2020): 3763-3775.

https://doi.org/10.1093/brain/awaa334